TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
REACT_19271	Semaphorin interactions	7.59366781198239e-07	-14.0907809335895	68	50	0.0158077774264938	3163	7167	5365,391,10154,9826,7094,389,5362,2064,4627,8482,80031,5361,9723,4628,57556,5364,23396,1020,91584,5880,727758,1808,3320,4233,3672,55558,2242,1072,9855,5058,6237,3326,23365,10570,9037,8851,388,1809,5788,2534,64218,10507,3984,3688,2932,23129,6093,8829,1400,103910	PLXNB3,RHOG,PLXNC1,ARHGEF11,TLN1,RHOC,PLXNA2,ERBB2,MYH9,SEMA7A,SEMA6D,PLXNA1,SEMA3E,MYH10,SEMA6A,PLXNB1,PIP5K1C,CDK5,PLXNA4,RAC2,ROCK1P1,DPYSL2,HSP90AA1,MET,ITGA1,PLXNA3,FES,CFL1,FARP2,PAK1,RRAS,HSP90AB1,ARHGEF12,DPYSL4,SEMA5A,CDK5R1,RHOB,DPYSL3,PTPRC,FYN,SEMA4A,SEMA4D,LIMK1,ITGB1,GSK3B,PLXND1,ROCK1,NRP1,CRMP1,MYL12B
REACT_111045	Developmental Biology	5.3805308796782e-06	-12.1327235121387	419	229	0.0723996206133418	3163	7167	10154,375790,6256,8912,8482,55740,5361,1432,4628,6710,27,1020,56924,1013,161,85441,6196,1499,1808,5216,4790,1739,1785,779,10752,55588,55558,10498,80205,4690,1630,1019,3312,50937,948,983,9969,1959,9037,1809,3785,5335,4087,3984,3688,4654,2932,6093,219699,8829,1400,103910,3172,8650,4208,7094,1495,389,7410,7204,6091,4205,285643,80031,1293,55090,5880,84246,1291,6720,57522,5105,3952,6386,22885,9443,9423,8911,1298,1052,5058,6237,3915,3786,285704,8841,3845,4902,10570,64221,5605,51129,1956,388,8851,3175,9043,10507,64218,160,51586,57113,6478,5306,9440,6329,6907,723961,4478,1000,57698,391,5365,26052,10637,1284,5313,1793,6195,5894,2657,288,5362,6586,2064,4627,57556,400569,5364,9441,10487,3651,6477,8986,389692,6900,4233,8515,2817,90390,1072,1292,7044,207,3326,8928,10025,4209,214,57731,2260,3630,4088,2534,3170,2645,9314,64096,688,51332,23129,23114,784,90249,96764,4089,6300,2675,1002,9612,1299,4656,6092,9826,6929,9723,284217,9252,6714,10298,4897,8828,23396,148738,25,91584,286,2048,727758,896,5781,5962,3642,5600,3320,1385,3672,10499,2242,5046,9855,4851,23380,3280,9439,79718,3174,80728,5045,23365,5747,2494,9901,84448,1051,5788,1879,8506,10000,1211,2668,390874,3685,3516,7026,3897,55800,3265,56963	PLXNC1,AGRN,RXRA,CACNA1H,SEMA7A,ENAH,PLXNA1,MAPK14,MYH10,SPTB,ABL2,CDK5,PAK6,CDH15,AP2A2,HELZ2,RPS6KA2,CTNNB1,DPYSL2,PFN1,NFKB1,DLG1,DNM2,CACNA1S,CHL1,MED29,PLXNA3,CARM1,CHD9,NCK1,DCC,CDK4,HSPA8,CDON,CD36,CDK1,MED13,EGR2,SEMA5A,DPYSL3,KCNQ2,PLCG1,SMAD2,LIMK1,ITGB1,MYOD1,GSK3B,ROCK1,UNC5B,NRP1,CRMP1,MYL12B,HNF4A,NUMB,MEF2C,TLN1,CTNNA1,RHOC,VAV2,TRIO,ROBO1,MEF2A,KIF4B,SEMA6D,COL6A3,MED9,RAC2,MED10,COL6A1,SREBF1,SRGAP1,PCK1,LEP,SDCBP,ABLIM3,MED7,NTN1,CACNA1I,COL9A2,CEBPD,PAK1,RRAS,LAMC1,KCNQ3,RGMB,HDAC3,KRAS,NRTN,DPYSL4,ROBO3,MAP2K2,ANGPTL4,EGFR,RHOB,CDK5R1,ONECUT1,SPAG9,SEMA4D,SEMA4A,AP2A1,MED15,TRPC7,SIAH2,PITPNA,MED17,SCN4A,TBL1X,INS-IGF2,MSN,CDH2,KIAA1598,RHOG,PLXNB3,DNM3,LEFTY1,COL4A2,PKLR,DOCK1,RPS6KA1,RAF1,GDF1,ANK3,PLXNA2,SLIT3,ERBB2,MYH9,SEMA6A,MED11,PLXNB1,MED26,CAP1,PDX1,SIAH1,RPS6KA4,MAFA,CNTN2,MET,ITGA10,GPC1,MED30,CFL1,COL6A2,LEFTY2,AKT1,HSP90AB1,FOXH1,MED16,MEF2D,ALCAM,SPTBN4,FGFR1,INS,SMAD3,FYN,FOXA2,GCK,KLF4,GFRA4,KLF5,SPTBN5,PLXND1,NFASC,CACNB3,UNC5A,TGS1,SMAD4,MAPK12,GFRA2,CDH4,NCOR2,COL9A3,MYOG,ROBO2,ARHGEF11,TCF3,SEMA3E,LAMA1,RPS6KA5,SRC,PAK4,NRCAM,NRP2,PIP5K1C,HFE2,ABL1,PLXNA4,ANK1,EPHB2,ROCK1P1,CCND3,PTPN11,RDX,INSM1,MAPK11,HSP90AA1,CREB1,ITGA1,NCOA2,FES,PCSK6,FARP2,NOTCH1,SRGAP2,HES1,MED23,TBL1XR1,HNF4G,ARHGAP39,FURIN,ARHGEF12,PTK2,NR5A2,SRGAP3,ABLIM2,CEBPB,PTPRC,EBF1,CNTNAP1,AKT3,CLTA,GDNF,ONECUT3,ITGAV,RBPJ,NR2F2,L1CAM,SCN3B,HRAS,RGMA
REACT_18266	Axon guidance	1.66605195627055e-05	-11.002468735475	262	149	0.0471071767309516	3163	7167	10154,375790,8912,8482,55740,5361,4628,6710,27,56924,1020,161,6196,5216,1808,1739,1785,10752,779,55558,4690,1630,3312,983,9037,1809,3785,5335,3984,3688,2932,6093,8829,219699,1400,103910,8650,7094,389,7410,7204,6091,285643,80031,1293,5880,1291,57522,22885,6386,9423,8911,1298,5058,6237,3915,3786,285704,3845,4902,10570,64221,5605,8851,1956,388,64218,10507,160,57113,6478,5306,6329,4478,57698,391,5365,26052,1284,1793,6195,5894,288,5362,4627,2064,6586,57556,5364,10487,6477,8986,6900,4233,8515,2817,1072,1292,3326,214,57731,2260,2534,64096,51332,23129,23114,784,90249,2675,1299,6092,9826,9723,284217,9252,4897,6714,10298,8828,23396,148738,25,91584,286,2048,727758,5781,5962,3320,3672,1385,2242,9855,23380,80728,23365,5747,84448,9901,8506,5788,2668,1211,3685,55800,3897,3265,56963	PLXNC1,AGRN,CACNA1H,SEMA7A,ENAH,PLXNA1,MYH10,SPTB,ABL2,PAK6,CDK5,AP2A2,RPS6KA2,PFN1,DPYSL2,DLG1,DNM2,CHL1,CACNA1S,PLXNA3,NCK1,DCC,HSPA8,CDK1,SEMA5A,DPYSL3,KCNQ2,PLCG1,LIMK1,ITGB1,GSK3B,ROCK1,NRP1,UNC5B,CRMP1,MYL12B,NUMB,TLN1,RHOC,VAV2,TRIO,ROBO1,KIF4B,SEMA6D,COL6A3,RAC2,COL6A1,SRGAP1,ABLIM3,SDCBP,NTN1,CACNA1I,COL9A2,PAK1,RRAS,LAMC1,KCNQ3,RGMB,KRAS,NRTN,DPYSL4,ROBO3,MAP2K2,CDK5R1,EGFR,RHOB,SEMA4A,SEMA4D,AP2A1,TRPC7,SIAH2,PITPNA,SCN4A,MSN,KIAA1598,RHOG,PLXNB3,DNM3,COL4A2,DOCK1,RPS6KA1,RAF1,ANK3,PLXNA2,MYH9,ERBB2,SLIT3,SEMA6A,PLXNB1,CAP1,SIAH1,RPS6KA4,CNTN2,MET,ITGA10,GPC1,CFL1,COL6A2,HSP90AB1,ALCAM,SPTBN4,FGFR1,FYN,GFRA4,SPTBN5,PLXND1,NFASC,CACNB3,UNC5A,GFRA2,COL9A3,ROBO2,ARHGEF11,SEMA3E,LAMA1,RPS6KA5,NRCAM,SRC,PAK4,NRP2,PIP5K1C,HFE2,ABL1,PLXNA4,ANK1,EPHB2,ROCK1P1,PTPN11,RDX,HSP90AA1,ITGA1,CREB1,FES,FARP2,SRGAP2,ARHGAP39,ARHGEF12,PTK2,ABLIM2,SRGAP3,CNTNAP1,PTPRC,GDNF,CLTA,ITGAV,SCN3B,L1CAM,HRAS,RGMA
REACT_299	Signaling by NOTCH	0.000284636634228945	-8.16429715877607	114	69	0.0218147328485615	3163	7167	142678,54567,3955,79885,10013,10402,92737,595,6484,182,28514,5664,55294,7311,51107,9978,1871,6487,9148,4192,9759,10046,6400,388585,6500,7088,7029,3066,8650,27327,9612,57690,8850,489,27161,2683,83933,5870,3714,4853,9734,3725,4609,51564,9794,1385,8788,7089,7091,3280,4851,6868,2648,79718,7090,8841,4242,5045,54492,7316,3091,5986,26508,1840,7027,408,113878,6907,3516	MIB2,DLL4,LFNG,HDAC11,HDAC6,ST3GAL6,DNER,CCND1,ST3GAL4,JAG1,DLL1,PSEN2,FBXW7,UBA52,APH1A,RBX1,E2F3,ST3GAL3,NEURL1,MDK,HDAC4,MAMLD1,SEL1L,HES5,SKP1,TLE1,TFDP2,HDAC2,NUMB,TNRC6A,NCOR2,TNRC6C,KAT2B,ATP2A3,AGO2,B4GALT1,HDAC10,RAB6A,JAG2,NOTCH2,HDAC9,JUN,MYC,HDAC7,MAML1,CREB1,DLK1,TLE2,TLE4,HES1,NOTCH1,ADAM17,KAT2A,TBL1XR1,TLE3,HDAC3,MFNG,FURIN,NEURL1B,UBC,HIF1A,RFNG,HEYL,DTX1,TFDP1,ARRB1,DTX2,TBL1X,RBPJ
REACT_11061	Signalling by NGF	0.000312248610900674	-8.07171085764527	284	154	0.048687954473601	3163	7167	7249,942,9542,1026,7531,5578,1432,84894,161,5136,6196,53358,4790,5296,5664,5290,1785,109,7074,5567,6453,1849,5159,64223,7311,51107,4914,5577,983,29,5898,5335,114,4254,2932,5528,3066,64857,27327,4208,2245,7204,7410,5900,4205,23239,8878,112,2264,23370,2889,7867,27006,8841,84033,3845,6016,4804,5605,1956,2248,9261,160,4792,3708,121512,4915,940,117,7189,685,26052,5607,1839,2475,5894,6195,5137,2064,5566,27237,25759,7409,5154,1399,6464,5518,5899,3551,89846,8503,3815,113,207,2931,2249,107,1894,4099,11214,1846,3710,2260,5515,2246,10718,2534,396,3084,393,6300,57690,9826,8874,22986,27161,79109,57142,9252,6714,2261,57449,3654,23263,5580,9138,117145,11108,5781,9181,5600,2065,1385,6774,5046,6199,5170,10451,2254,6868,3164,5295,5575,5045,23365,7316,57761,111,10000,26281,8817,1211,3265,50649	TSC2,CD86,NRG2,CDKN1A,YWHAE,PRKCA,MAPK14,LINGO1,AP2A2,PDE1A,RPS6KA2,SHC3,NFKB1,PIK3R2,PSEN2,PIK3CA,DNM2,ADCY3,TIAM1,PRKACB,ITSN1,DUSP7,PDGFRB,MLST8,UBA52,APH1A,NTRK1,PRKAR2B,CDK1,ABR,RALA,PLCG1,ADCY8,KITLG,GSK3B,PPP2R5D,HDAC2,PLEKHG2,TNRC6A,MEF2C,FGD1,TRIO,VAV2,RALGDS,MEF2A,PHLPP1,SQSTM1,ADCY6,FGFR4,ARHGEF18,RAPGEF1,MAPKAPK3,FGF22,HDAC3,OBSCN,KRAS,RIT1,NGFR,MAP2K2,EGFR,FGF3,MAPKAPK2,AP2A1,NFKBIA,ITPR1,FGD4,NTRK2,CD28,ADCYAP1R1,TRAF6,BTC,DNM3,MAP2K5,HBEGF,MTOR,RAF1,RPS6KA1,PDE1C,ERBB2,PRKACA,ARHGEF16,SHC2,VAV1,PDGFA,CRKL,SHC1,PPP2R1A,RALB,IKBKB,FGD3,PIK3R3,KIT,ADCY7,AKT1,GSK3A,FGF4,ADCY1,ECT2,MAG,AKAP13,DUSP4,ITPR3,FGFR1,PPP2CA,FGF1,NRG3,FYN,ARHGDIA,NRG1,ARHGAP4,MAPK12,TNRC6C,ARHGEF11,ARHGEF7,SORCS3,AGO2,MAPKAP1,RTN4,RPS6KA5,SRC,FGFR3,PLEKHG5,IRAK1,MCF2L,PRKCD,ARHGEF1,THEM4,PRDM4,PTPN11,ARHGEF2,MAPK11,ERBB3,CREB1,STAT3,PCSK6,RPS6KB2,PDPK1,VAV3,FGF9,ADAM17,NR4A1,PIK3R1,PRKAR1B,FURIN,ARHGEF12,UBC,TRIB3,ADCY5,AKT3,FGF20,FGF18,CLTA,HRAS,ARHGEF4
REACT_160248	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_160082	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_160133	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_160301	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_160214	Signaling by NOTCH1 in Cancer	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_118859	Signaling by NOTCH1	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_160099	FBXW7 Mutants and NOTCH1 in Cancer	0.000367407447726468	-7.90903911395031	73	47	0.0148593107809042	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,92737,9734,182,28514,51564,4609,5664,55294,9794,7089,8788,7091,4851,3280,6868,7311,2648,51107,9978,79718,7090,8841,54492,7316,9148,9759,3091,26508,1840,10046,388585,6500,7088,408,113878,3516,6907,3066,8650	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,DNER,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,TLE2,DLK1,TLE4,NOTCH1,HES1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,TLE3,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HIF1A,HEYL,DTX1,MAMLD1,HES5,SKP1,TLE1,ARRB1,DTX2,RBPJ,TBL1X,HDAC2,NUMB
REACT_19200	Other semaphorin interactions	0.000396959155387002	-7.83167716572609	19	16	0.00505848877647803	3163	7167	5365,10154,5362,8482,80031,5361,9723,57556,9037,5788,91584,64218,10507,3688,23129,3672	PLXNB3,PLXNC1,PLXNA2,SEMA7A,SEMA6D,PLXNA1,SEMA3E,SEMA6A,SEMA5A,PTPRC,PLXNA4,SEMA4A,SEMA4D,ITGB1,PLXND1,ITGA1
REACT_19199	CRMPs in Sema3A signaling	0.000436671476627013	-7.73632941532149	16	14	0.00442617767941827	3163	7167	1020,91584,2534,1808,5362,2932,5361,8829,1400,10570,55558,8851,2242,1809	CDK5,PLXNA4,FYN,DPYSL2,PLXNA2,GSK3B,PLXNA1,NRP1,CRMP1,DPYSL4,PLXNA3,CDK5R1,FES,DPYSL3
REACT_11051	Rho GTPase cycle	0.000618335923204385	-7.38847868312892	124	73	0.023079355042681	3163	7167	398,391,23092,29984,10928,58504,10395,54509,115703,5881,27237,7409,84986,5296,89846,57381,55615,7074,9754,6453,23779,89839,23526,1894,11214,257106,29,58480,51291,396,393,90627,64857,2245,117289,64411,9826,389,8874,7204,7410,4650,84144,57449,5880,1124,2665,23263,51306,57522,9181,392,613,23370,10451,23380,116984,80728,84033,23365,9743,89941,388,9901,83478,553158,64333,116985,171177,23221,121512,57636,50649	ARHGDIG,RHOG,ARHGAP26,RHOD,RALBP1,ARHGAP22,DLC1,RHOF,ARHGAP33,RAC3,ARHGEF16,VAV1,ARHGAP19,PIK3R2,FGD3,RHOJ,PRR5,TIAM1,STARD8,ITSN1,ARHGAP8,ARHGAP11B,HMHA1,ECT2,AKAP13,ARHGAP30,ABR,RHOU,GMIP,ARHGDIA,ARHGAP4,STARD13,PLEKHG2,FGD1,TAGAP,ARAP3,ARHGEF11,RHOC,ARHGEF7,TRIO,VAV2,MYO9B,SYDE2,PLEKHG5,RAC2,CHN2,GDI2,MCF2L,FAM13B,SRGAP1,ARHGEF2,ARHGAP1,BCR,ARHGEF18,VAV3,SRGAP2,ARAP2,ARHGAP39,OBSCN,ARHGEF12,ARHGAP32,RHOT2,RHOB,SRGAP3,ARHGAP24,PRR5-ARHGAP8,ARHGAP9,ARAP1,RHOV,RHOBTB2,FGD4,ARHGAP23,ARHGEF4
REACT_11044	Signaling by Rho GTPases	0.000618335923204385	-7.38847868312892	124	73	0.023079355042681	3163	7167	398,391,23092,29984,10928,58504,10395,54509,115703,5881,27237,7409,84986,5296,89846,57381,55615,7074,9754,6453,23779,89839,23526,1894,11214,257106,29,58480,51291,396,393,90627,64857,2245,117289,64411,9826,389,8874,7204,7410,4650,84144,57449,5880,1124,2665,23263,51306,57522,9181,392,613,23370,10451,23380,116984,80728,84033,23365,9743,89941,388,9901,83478,553158,64333,116985,171177,23221,121512,57636,50649	ARHGDIG,RHOG,ARHGAP26,RHOD,RALBP1,ARHGAP22,DLC1,RHOF,ARHGAP33,RAC3,ARHGEF16,VAV1,ARHGAP19,PIK3R2,FGD3,RHOJ,PRR5,TIAM1,STARD8,ITSN1,ARHGAP8,ARHGAP11B,HMHA1,ECT2,AKAP13,ARHGAP30,ABR,RHOU,GMIP,ARHGDIA,ARHGAP4,STARD13,PLEKHG2,FGD1,TAGAP,ARAP3,ARHGEF11,RHOC,ARHGEF7,TRIO,VAV2,MYO9B,SYDE2,PLEKHG5,RAC2,CHN2,GDI2,MCF2L,FAM13B,SRGAP1,ARHGEF2,ARHGAP1,BCR,ARHGEF18,VAV3,SRGAP2,ARAP2,ARHGAP39,OBSCN,ARHGEF12,ARHGAP32,RHOT2,RHOB,SRGAP3,ARHGAP24,PRR5-ARHGAP8,ARHGAP9,ARAP1,RHOV,RHOBTB2,FGD4,ARHGAP23,ARHGEF4
REACT_19358	CD28 dependent PI3K/Akt signaling	0.000628846233121838	-7.37162379359506	21	17	0.0053746443250079	3163	7167	5170,207,942,2475,1326,5295,79109,57761,2534,10000,117145,5296,5290,8503,9020,940,64223	PDPK1,AKT1,CD86,MTOR,MAP3K8,PIK3R1,MAPKAP1,TRIB3,FYN,AKT3,THEM4,PIK3R2,PIK3CA,PIK3R3,MAP3K14,CD28,MLST8
REACT_120870	Phospholipid metabolism	0.00121173309471414	-6.71570363446947	140	80	0.0252924438823901	3163	7167	5321,4534,3635,57104,55500,10162,1120,64900,10423,8867,151056,23761,23175,1040,56623,3631,55326,9110,5296,23446,5290,8503,23171,56261,79143,8399,7179,55300,8605,10555,10400,8821,22908,5287,154141,129642,56994,8760,3636,80736,56894,55224,5338,81579,375,5305,100137049,23396,2819,51763,5298,23533,8871,8694,79888,122618,8398,123745,85465,150763,56895,9926,9489,5295,50640,8394,5286,55697,55361,283748,255189,201164,8443,1103,254531,84649,5337,57678,8776,43	PLA2G4A,MTM1,INPP5D,PNPLA2,ETNK1,LPCAT3,CHKB,LPIN3,CDIPT,SYNJ1,PLB1,PISD,LPIN1,CDS1,INPP5E,INPP4A,AGPAT5,MTMR4,PIK3R2,SLC44A1,PIK3CA,PIK3R3,GPD1L,GPCPD1,MBOAT7,PLA2G10,TPTE,PI4K2B,PLA2G4C,AGPAT2,PEMT,INPP4B,SACM1L,PIK3C2B,MBOAT1,MBOAT2,CHPT1,CDS2,INPPL1,SLC44A4,AGPAT3,ETNK2,PLD2,PLA2G12A,ARF1,PIP4K2A,PLA2G4B,PIP5K1C,GPD1,INPP5K,PI4KB,PIK3R5,SYNJ2,DGAT1,LPCAT1,PLD4,PLA2G6,PLA2G4E,EPT1,GPAT2,AGPAT4,LPGAT1,PGS1,PIK3R1,PNPLA8,PIP5K1A,PIK3C2A,VAC14,PI4K2A,PLA2G4D,PLA2G4F,PLD6,GNPAT,CHAT,LPCAT4,DGAT2,PLD1,GPAM,MTMR1,ACHE
REACT_1695	GPVI-mediated activation cascade	0.0013660234448789	-6.59585135481911	32	23	0.00727157761618716	3163	7167	5170,391,10451,27040,2207,207,7410,5295,3937,4067,388,7409,5880,2534,23533,10000,5336,5296,5290,5590,8503,51206,6850	PDPK1,RHOG,VAV3,LAT,FCER1G,AKT1,VAV2,PIK3R1,LCP2,LYN,RHOB,VAV1,RAC2,FYN,PIK3R5,AKT3,PLCG2,PIK3R2,PIK3CA,PRKCZ,PIK3R3,GP6,SYK
REACT_6964	mTORC1-mediated signalling	0.00183376801366801	-6.30138240515083	11	10	0.00316155548529877	3163	7167	57521,1981,1975,2475,1978,6198,1977,6009,29904,64223	RPTOR,EIF4G1,EIF4B,MTOR,EIF4EBP1,RPS6KB1,EIF4E,RHEB,EEF2K,MLST8
REACT_18356	Unfolded Protein Response	0.0021771872663644	-6.12972148005058	83	50	0.0158077774264938	3163	7167	1663,3068,118,7094,64061,5611,9451,5073,100137049,4189,4000,6745,58477,811,440,6464,9695,56915,54512,56005,10130,55033,9114,440081,10113,51360,7709,468,2931,3484,3309,467,84447,27230,9709,167227,6818,22872,10897,55738,4800,7466,3576,8570,22926,445329,37,8720,116138,1649	DDX11,HDGF,ADD1,TLN1,TSPYL2,DNAJC3,EIF2AK3,PARN,PLA2G4B,DNAJB9,LMNA,SSR1,SRPRB,CALR,ASNS,SHC1,EDEM1,EXOSC5,EXOSC4,C19orf10,PDIA6,FKBP14,ATP6V0D1,DDX12P,PREB,MBTPS2,ZBTB17,ATF4,GSK3A,IGFBP1,HSPA5,ATF3,SYVN1,SERP1,HERPUD1,DCP2,SULT1A3,SEC31A,YIF1A,ARFGAP1,NFYA,WFS1,IL8,KHSRP,ATF6,SULT1A4,ACADVL,MBTPS1,KLHDC3,DDIT3
REACT_147797	Regulation of Cholesterol Biosynthesis by SREBP (SREBF)	0.00255317308433233	-5.97041834657264	53	34	0.0107492886500158	3163	7167	4598,51141,6256,9453,10654,85441,3157,3422,6720,10499,3837,10498,51360,3156,6667,2222,10802,80205,79718,79071,2194,7108,51128,4047,4800,3638,22937,2224,6713,6907,57678,96764,1717,8720	MVK,INSIG2,RXRA,GGPS1,PMVK,HELZ2,HMGCS1,IDI1,SREBF1,NCOA2,KPNB1,CARM1,MBTPS2,HMGCR,SP1,FDFT1,SEC24A,CHD9,TBL1XR1,ELOVL6,FASN,TM7SF2,SAR1B,LSS,NFYA,INSIG1,SCAP,FDPS,SQLE,TBL1X,GPAM,TGS1,DHCR7,MBTPS1
REACT_147719	MPS VI - Maroteaux-Lamy syndrome	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147853	Mucopolysaccharidoses	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147749	MPS IIID - Sanfilippo syndrome D	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147825	MPS IV - Morquio syndrome A	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147788	MPS IIIB - Sanfilippo syndrome B	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_121315	Glycosaminoglycan metabolism	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147739	MPS IX - Natowicz syndrome	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147753	MPS IIIA - Sanfilippo syndrome A	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147857	MPS I - Hurler syndrome	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147734	MPS II - Hunter syndrome	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147798	MPS IV - Morquio syndrome B	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147860	MPS IIIC - Sanfilippo syndrome C	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_147759	MPS VII - Sly syndrome	0.00274238146911268	-5.89892858676251	121	69	0.0218147328485615	3163	7167	4166,375790,3339,2131,64711,63827,10402,6382,3037,8692,79586,6484,2331,9951,9061,3373,1836,633,2817,55454,6487,3340,5549,9394,8372,10855,51363,4669,6483,92126,9953,8703,166012,6482,9955,266722,10090,55576,50515,8534,9957,6385,26229,2683,10861,113189,22856,8702,3038,6548,960,3425,1464,126792,337876,3161,93010,8509,9672,3423,6448,1462,55790,176,9469,411,27087,11285,10331	CHST6,AGRN,HSPG2,EXT1,HS3ST6,BCAN,ST3GAL6,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,HS3ST4,PAPSS1,HYAL1,SLC26A2,BGN,GPC1,CSGALNACT2,ST3GAL3,NDST1,PRELP,HS6ST1,HYAL3,HPSE,CHST15,NAGLU,ST3GAL2,DSEL,HS3ST3B1,B4GALT3,CHST13,ST3GAL1,HS3ST3A1,HS6ST3,UST,STAB2,CHST11,CHST1,HS3ST1,SDC4,B3GAT3,B4GALT1,SLC26A1,CHST14,CHSY1,B4GALT4,HAS3,SLC9A1,CD44,IDUA,CSPG4,B3GALT6,CHSY3,HMMR,B3GNT7,NDST2,SDC3,IDS,SGSH,VCAN,CSGALNACT1,ACAN,CHST3,ARSB,B3GAT1,B4GALT7,B3GNT3
REACT_604	Hemostasis	0.00329260639859803	-5.71607580942538	495	248	0.0784065760354094	3163	7167	3779,126961,5023,2769,57126,2625,2782,2812,8358,50848,11004,9002,25942,5578,1432,26153,1020,7465,5136,5216,5296,5290,3835,10411,5345,55604,5567,7277,2147,27040,6647,492,10257,2788,3309,3021,5577,857,2316,7422,948,9630,23539,3689,5335,64145,2627,59345,226,1675,3688,81,5054,1191,140628,5528,23764,284,3066,2335,7094,6403,489,3655,1609,7410,9493,285643,5055,51744,10019,5880,3675,23533,10846,30846,84876,22920,2771,10112,9948,221037,641455,11069,3845,830,2767,388,8165,747,10603,3708,2886,57113,7450,11127,7534,51206,23468,4843,91768,5152,333932,3659,10938,23348,5321,391,3797,2207,1793,3635,5894,1606,9123,8527,3661,161882,3937,5566,4067,1794,2783,351,5139,7409,5154,6464,27154,10487,5518,5336,8503,56301,81928,5627,8515,3687,462,7414,55423,81704,1072,152,7044,207,6404,5777,2162,2815,5868,87,4099,481,3710,83700,548645,3796,5515,5529,2534,5525,2983,7975,9162,5590,5624,346562,3665,3082,3020,23428,7804,8525,2888,22927,11311,6402,682,88,5028,2621,7042,4352,6714,2153,9057,140885,965,5583,25,5770,2793,6678,5580,147700,5781,928,5593,653604,3717,51764,50808,3672,960,8832,6850,150,2165,5170,10451,2626,7066,5329,5739,3778,5295,5575,813,491,2786,23186,10335,5747,23414,5138,9564,9927,2768,2268,2159,5265,221955,5547,10000,11136,8140,2734,408,51378,5660,3685,2155,9046,3897,57572,3265,493	KCNMB1,HIST2H3C,P2RX1,GNA15,CD177,GATA3,GNB1,GP1BB,HIST1H3B,F11R,KIF2C,F2RL3,SIN3A,PRKCA,MAPK14,KIF26A,CDK5,WEE1,PDE1A,PFN1,PIK3R2,PIK3CA,KIF22,RAPGEF3,SERPINF2,LRRC16A,PRKACB,TUBA4A,F2,LAT,SOD1,ATP2B3,ABCC4,GNG7,HSPA5,H3F3B,PRKAR2B,CAV1,FLNA,VEGFA,CD36,GNA14,SLC16A8,ITGB2,PLCG1,ZFYVE20,GATA6,GNB4,ALDOA,CFD,ITGB1,ACTN4,SERPINE1,CLU,GATA5,PPP2R5D,MAFF,ANGPT1,HDAC2,FN1,TLN1,SELP,ATP2A3,ITGA6,DGKQ,VAV2,KIF23,KIF4B,SERPINB2,CD244,SH2B3,RAC2,ITGA3,PIK3R5,PDE10A,EHD2,ORAI1,KIFAP3,GNAI2,KIF20A,WDR1,JMJD1C,POTEM,RAPGEF4,KRAS,CAPZA2,GNA11,RHOB,AKAP1,DAGLA,SH2B2,ITPR1,GRB7,TRPC7,VWF,KIF3A,YWHAZ,GP6,CBX5,NOS2,CABLES1,PDE9A,HIST2H3A,IRF1,EHD1,DOCK9,PLA2G4A,RHOG,KIF3C,FCER1G,DOCK1,INPP5D,RAF1,DGKA,SLC16A3,DGKD,IRF3,ZFPM1,LCP2,PRKACA,LYN,DOCK2,GNB2,APP,PDE3A,VAV1,PDGFA,SHC1,BRPF3,CAP1,PPP2R1A,PLCG2,PIK3R3,SLC7A10,CABLES2,PROS1,ITGA10,ITGAX,SERPINC1,VCL,SIRPG,DOCK8,CFL1,ADRA2C,LEFTY2,AKT1,SELPLG,PTPN6,F13A1,GP9,RAB5A,ACTN1,MAG,ATP1B1,ITPR3,JAM3,DNAJC25,KIF2A,PPP2CA,PPP2R5E,FYN,PPP2R5A,GUCY1B3,MAFK,DGKI,PRKCZ,PROC,GNAT3,IRF7,HGF,H3F3A,SLC7A8,LRP8,DGKZ,GRB14,HABP4,VPS45,SELL,BSG,ACTN2,P2RY1,GAS6,TGFB2,MPL,SRC,F5,SLC7A6,SIRPA,CD58,PRKCH,ABL1,PTPN1,GNGT2,SPARC,PRKCD,KLC3,PTPN11,CD9,PRKG2,HIST2H3D,JAK2,GNG13,AK3,ITGA1,CD44,CD84,SYK,ADRA2A,F13B,PDPK1,VAV3,GATA4,THPO,PLAUR,PTGIR,KCNMA1,PIK3R1,PRKAR1B,CALU,ATP2B2,GNG4,RCOR1,MRVI1,PTK2,ZFPM2,PDE2A,BCAR1,MFN2,GNA12,FGR,F10,SERPINA1,DAGLB,PRCP,AKT3,SLC7A9,SLC7A5,GLG1,ARRB1,ANGPT4,PSAP,ITGAV,F7,DOK2,L1CAM,DOCK6,HRAS,ATP2B4
REACT_118780	NOTCH1 Intracellular Domain Regulates Transcription	0.00335337381810509	-5.69778833005797	48	31	0.00980082200442618	3163	7167	7091,4851,9612,3280,7311,2648,8850,79718,9978,7090,8841,79885,83933,10013,7316,9734,9759,3091,51564,26508,4609,10046,388585,6500,7088,55294,3516,6907,9794,3066,7089	TLE4,NOTCH1,NCOR2,HES1,UBA52,KAT2A,KAT2B,TBL1XR1,RBX1,TLE3,HDAC3,HDAC11,HDAC10,HDAC6,UBC,HDAC9,HDAC4,HIF1A,HDAC7,HEYL,MYC,MAMLD1,HES5,SKP1,TLE1,FBXW7,RBPJ,TBL1X,MAML1,HDAC2,TLE2
REACT_12065	p38MAPK events	0.00340753514220093	-5.681766081255	13	11	0.00347771103382864	3163	7167	9261,5898,5899,7867,5900,5600,3845,1432,6714,3265,6300	MAPKAPK2,RALA,RALB,MAPKAPK3,RALGDS,MAPK11,KRAS,MAPK14,SRC,HRAS,MAPK12
REACT_18407	G alpha (12/13) signalling events	0.00412998604033867	-5.48948125207818	79	47	0.0148593107809042	3163	7167	391,9826,8874,389,7410,7204,2782,2783,27237,5364,147,7409,5880,57449,727758,2793,23263,5296,9138,89846,5290,9181,8503,51764,7074,148,6453,23370,10451,2788,5295,1894,2786,84033,23365,11214,548645,29,388,2768,59345,121512,6093,393,64857,50649,2245	RHOG,ARHGEF11,ARHGEF7,RHOC,VAV2,TRIO,GNB1,GNB2,ARHGEF16,PLXNB1,ADRA1B,VAV1,RAC2,PLEKHG5,ROCK1P1,GNGT2,MCF2L,PIK3R2,ARHGEF1,FGD3,PIK3CA,ARHGEF2,PIK3R3,GNG13,TIAM1,ADRA1A,ITSN1,ARHGEF18,VAV3,GNG7,PIK3R1,ECT2,GNG4,OBSCN,ARHGEF12,AKAP13,DNAJC25,ABR,RHOB,GNA12,GNB4,FGD4,ROCK1,ARHGAP4,PLEKHG2,ARHGEF4,FGD1
REACT_160243	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.00438068352892161	-5.43055050993796	58	36	0.0113815997470756	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,9734,182,28514,51564,4609,5664,55294,9794,3280,4851,6868,7311,2648,51107,9978,79718,8841,54492,7316,9148,9759,26508,10046,388585,6500,6907,3516,3066	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,HES1,NOTCH1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HEYL,MAMLD1,HES5,SKP1,TBL1X,RBPJ,HDAC2
REACT_160254	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.00438068352892161	-5.43055050993796	58	36	0.0113815997470756	3163	7167	142678,9612,54567,8850,79885,3714,83933,10013,9734,182,28514,51564,4609,5664,55294,9794,3280,4851,6868,7311,2648,51107,9978,79718,8841,54492,7316,9148,9759,26508,10046,388585,6500,6907,3516,3066	MIB2,NCOR2,DLL4,KAT2B,HDAC11,JAG2,HDAC10,HDAC6,HDAC9,JAG1,DLL1,HDAC7,MYC,PSEN2,FBXW7,MAML1,HES1,NOTCH1,ADAM17,UBA52,KAT2A,APH1A,RBX1,TBL1XR1,HDAC3,NEURL1B,UBC,NEURL1,HDAC4,HEYL,MAMLD1,HES5,SKP1,TBL1X,RBPJ,HDAC2
REACT_120729	Collagen formation	0.00440126840287137	-5.42586250622085	87	51	0.0161239329750237	3163	7167	4318,5479,1299,1284,55214,1508,3655,1295,977,5351,79709,80781,84695,7373,1293,3914,667,169044,3909,64175,1520,5034,1291,1280,1289,1310,4016,1298,4015,9509,1292,91522,10536,1277,1296,23127,1294,5339,1303,136227,1305,5352,9508,1306,1515,649,140766,3691,3918,1307,57642	MMP9,PPIB,COL9A3,COL4A2,LEPREL1,CTSB,ITGA6,COL8A1,CD151,PLOD1,COLGALT1,COL18A1,LOXL3,COL14A1,COL6A3,LAMB3,DST,COL22A1,LAMA3,LEPRE1,CTSS,P4HB,COL6A1,COL2A1,COL5A1,COL19A1,LOXL1,COL9A2,LOX,ADAMTS2,COL6A2,COL23A1,LEPREL2,COL1A1,COL8A2,COLGALT2,COL7A1,PLEC,COL12A1,COL26A1,COL13A1,PLOD2,ADAMTS3,COL15A1,CTSV,BMP1,ADAMTS14,ITGB4,LAMC2,COL16A1,COL20A1
REACT_19236	Sema3A PAK dependent Axon repulsion	0.0051751974129064	-5.26387779313677	15	12	0.00379386658235852	3163	7167	5058,91584,2534,3984,3326,5362,5361,3320,8829,55558,1072,2242	PAK1,PLXNA4,FYN,LIMK1,HSP90AB1,PLXNA2,PLXNA1,HSP90AA1,NRP1,PLXNA3,CFL1,FES
REACT_18273	Activation of Chaperone Genes by XBP1(S)	0.00530813396640606	-5.23851492424625	49	31	0.00980082200442618	3163	7167	7709,3068,1663,2931,118,64061,7094,5611,84447,100137049,27230,4000,4189,6818,6745,58477,10897,22872,55738,6464,9695,7466,56005,445329,10130,37,55033,440081,9114,116138,10113	ZBTB17,HDGF,DDX11,GSK3A,ADD1,TSPYL2,TLN1,DNAJC3,SYVN1,PLA2G4B,SERP1,LMNA,DNAJB9,SULT1A3,SSR1,SRPRB,YIF1A,SEC31A,ARFGAP1,SHC1,EDEM1,WFS1,C19orf10,SULT1A4,PDIA6,ACADVL,FKBP14,DDX12P,ATP6V0D1,KLHDC3,PREB
REACT_12056	NGF signalling via TRKA from the plasma membrane	0.00531588959285823	-5.23705490718462	201	107	0.0338286436926968	3163	7167	685,1839,5607,26052,7249,942,2475,6195,5894,5137,2064,9542,1026,5578,1432,5566,25759,1399,5154,7409,161,6196,5136,6464,5518,53358,5899,5296,5290,1785,109,8503,3815,5567,1849,5159,113,64223,2931,207,2249,4914,107,5577,1846,3710,983,2260,2246,5515,5898,5335,2534,10718,114,4254,2932,3084,5528,27327,4208,6300,57690,27161,5900,79109,4205,23239,9252,6714,2261,117145,5580,5781,112,5600,2065,1385,6774,6199,2264,5170,2254,2889,7867,3164,27006,5295,5575,3845,6016,5605,1956,2248,9261,57761,10000,160,111,26281,8817,3708,1211,4915,117,3265,940	BTC,HBEGF,MAP2K5,DNM3,TSC2,CD86,MTOR,RPS6KA1,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,MAPK14,PRKACA,SHC2,CRKL,PDGFA,VAV1,AP2A2,RPS6KA2,PDE1A,SHC1,PPP2R1A,SHC3,RALB,PIK3R2,PIK3CA,DNM2,ADCY3,PIK3R3,KIT,PRKACB,DUSP7,PDGFRB,ADCY7,MLST8,GSK3A,AKT1,FGF4,NTRK1,ADCY1,PRKAR2B,DUSP4,ITPR3,CDK1,FGFR1,FGF1,PPP2CA,RALA,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,PPP2R5D,TNRC6A,MEF2C,MAPK12,TNRC6C,AGO2,RALGDS,MAPKAP1,MEF2A,PHLPP1,RPS6KA5,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,MAPK11,ERBB3,CREB1,STAT3,RPS6KB2,FGFR4,PDPK1,FGF9,RAPGEF1,MAPKAPK3,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,RIT1,MAP2K2,EGFR,FGF3,MAPKAPK2,TRIB3,AKT3,AP2A1,ADCY5,FGF20,FGF18,ITPR1,CLTA,NTRK2,ADCYAP1R1,HRAS,CD28
REACT_18368	Activation of Chaperones by IRE1alpha	0.00558166295767196	-5.18826852590022	51	32	0.0101169775529561	3163	7167	7709,1663,3068,2931,118,7094,64061,5611,3309,84447,27230,100137049,4189,4000,6818,6745,58477,22872,10897,55738,6464,9695,7466,56005,445329,10130,37,55033,9114,440081,116138,10113	ZBTB17,DDX11,HDGF,GSK3A,ADD1,TLN1,TSPYL2,DNAJC3,HSPA5,SYVN1,SERP1,PLA2G4B,DNAJB9,LMNA,SULT1A3,SSR1,SRPRB,SEC31A,YIF1A,ARFGAP1,SHC1,EDEM1,WFS1,C19orf10,SULT1A4,PDIA6,ACADVL,FKBP14,ATP6V0D1,DDX12P,KLHDC3,PREB
REACT_150401	Collagen degradation	0.00574474182979406	-5.15947030693416	38	25	0.00790388871324692	3163	7167	4318,1299,6868,4320,91522,1508,5045,4327,80781,1513,7373,5645,1303,4324,136227,1305,4317,1306,4313,4323,8754,1310,1509,1298,1307	MMP9,COL9A3,ADAM17,MMP11,COL23A1,CTSB,FURIN,MMP19,COL18A1,CTSK,COL14A1,PRSS2,COL12A1,MMP15,COL26A1,COL13A1,MMP8,COL15A1,MMP2,MMP14,ADAM9,COL19A1,CTSD,COL9A2,COL16A1
REACT_121401	Glycerophospholipid biosynthesis	0.00608560544793063	-5.1018290590649	90	52	0.0164400885235536	3163	7167	5321,8760,80736,57104,55500,56894,10162,81579,5338,55224,1120,64900,10423,151056,100137049,23761,23175,2819,1040,55326,23446,8694,79888,122618,23171,8398,123745,85465,150763,9926,56895,9489,56261,50640,79143,8399,283748,8605,10555,255189,201164,10400,8443,1103,254531,84649,154141,5337,57678,129642,56994,43	PLA2G4A,CDS2,SLC44A4,PNPLA2,ETNK1,AGPAT3,LPCAT3,PLA2G12A,PLD2,ETNK2,CHKB,LPIN3,CDIPT,PLB1,PLA2G4B,PISD,LPIN1,GPD1,CDS1,AGPAT5,SLC44A1,DGAT1,LPCAT1,PLD4,GPD1L,PLA2G6,PLA2G4E,EPT1,GPAT2,LPGAT1,AGPAT4,PGS1,GPCPD1,PNPLA8,MBOAT7,PLA2G10,PLA2G4D,PLA2G4C,AGPAT2,PLA2G4F,PLD6,PEMT,GNPAT,CHAT,LPCAT4,DGAT2,MBOAT1,PLD1,GPAM,MBOAT2,CHPT1,ACHE
REACT_147904	Activation of Gene Expression by SREBP (SREBF)	0.00620336493895938	-5.08266340206666	40	26	0.00822004426177679	3163	7167	80205,4598,79718,79071,6256,2194,7108,9453,10654,4047,85441,4800,3157,3422,2224,6720,6713,57678,6907,1717,96764,10499,10498,3156,6667,2222	CHD9,MVK,TBL1XR1,ELOVL6,RXRA,FASN,TM7SF2,GGPS1,PMVK,LSS,HELZ2,NFYA,HMGCS1,IDI1,FDPS,SREBF1,SQLE,GPAM,TBL1X,DHCR7,TGS1,NCOA2,CARM1,HMGCR,SP1,FDFT1
REACT_6836	Release of eIF4E	0.0073691795716907	-4.91044889896511	6	6	0.00189693329117926	3163	7167	57521,2475,1977,1978,6009,64223	RPTOR,MTOR,EIF4E,EIF4EBP1,RHEB,MLST8
REACT_733	Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.00783931295906017	-4.84860408123273	9	8	0.00252924438823901	3163	7167	2147,5627,2159,2621,2155,8858,5045,5624	F2,PROS1,F10,GAS6,F7,PROZ,FURIN,PROC
REACT_6754	S6K1-mediated signalling	0.00783931295906017	-4.84860408123273	9	8	0.00252924438823901	3163	7167	57521,1981,6198,1975,2475,6009,64223,29904	RPTOR,EIF4G1,RPS6KB1,EIF4B,MTOR,RHEB,MLST8,EEF2K
REACT_20537	Type I hemidesmosome assembly	0.00783931295906017	-4.84860408123273	9	8	0.00252924438823901	3163	7167	667,3909,3655,977,5339,3691,3918,3914	DST,LAMA3,ITGA6,CD151,PLEC,ITGB4,LAMC2,LAMB3
REACT_798	Platelet activation, signaling and aggregation	0.00875008794151389	-4.73869152820439	214	112	0.0354094214353462	3163	7167	5321,391,2207,2769,5894,1606,2782,2812,8527,9002,3937,5578,1432,4067,2783,351,5154,7409,6464,10487,27154,5216,5336,5296,5290,8503,5627,10411,5345,7414,1072,7277,152,2147,27040,6647,7044,10257,207,2788,3309,2162,2815,87,2316,3710,7422,948,548645,9630,2534,59345,9162,226,1675,5590,346562,81,5054,3082,1191,8525,2335,6403,7094,1609,22927,7410,88,5028,2621,7042,4352,6714,2153,5583,5880,5770,23533,2793,6678,5580,928,51764,2771,6850,150,5170,10451,7066,9948,11069,5295,641455,813,2786,5747,9564,2767,388,747,2768,5265,221955,10000,57113,3708,408,7450,51206,7534,5660	PLA2G4A,RHOG,FCER1G,GNA15,RAF1,DGKA,GNB1,GP1BB,DGKD,F2RL3,LCP2,PRKCA,MAPK14,LYN,GNB2,APP,PDGFA,VAV1,SHC1,CAP1,BRPF3,PFN1,PLCG2,PIK3R2,PIK3CA,PIK3R3,PROS1,RAPGEF3,SERPINF2,VCL,CFL1,TUBA4A,ADRA2C,F2,LAT,SOD1,LEFTY2,ABCC4,AKT1,GNG7,HSPA5,F13A1,GP9,ACTN1,FLNA,ITPR3,VEGFA,CD36,DNAJC25,GNA14,FYN,GNB4,DGKI,ALDOA,CFD,PRKCZ,GNAT3,ACTN4,SERPINE1,HGF,CLU,DGKZ,FN1,SELP,TLN1,DGKQ,HABP4,VAV2,ACTN2,P2RY1,GAS6,TGFB2,MPL,SRC,F5,PRKCH,RAC2,PTPN1,PIK3R5,GNGT2,SPARC,PRKCD,CD9,GNG13,GNAI2,SYK,ADRA2A,PDPK1,VAV3,THPO,WDR1,RAPGEF4,PIK3R1,POTEM,CALU,GNG4,PTK2,BCAR1,GNA11,RHOB,DAGLA,GNA12,SERPINA1,DAGLB,AKT3,TRPC7,ITPR1,ARRB1,VWF,GP6,YWHAZ,PSAP
REACT_24941	Circadian Clock	0.00899716136700536	-4.71084615506219	56	34	0.0107492886500158	3163	7167	6256,8553,6095,8864,10135,85441,79365,6720,1408,1385,1386,9572,10499,10498,80205,7311,79718,2908,1454,8841,4209,7316,3091,5187,406,6500,5054,6907,25819,2155,96764,8945,1453,4208	RXRA,BHLHE40,RORA,PER2,NAMPT,HELZ2,BHLHE41,SREBF1,CRY2,CREB1,ATF2,NR1D1,NCOA2,CARM1,CHD9,UBA52,TBL1XR1,NR3C1,CSNK1E,HDAC3,MEF2D,UBC,HIF1A,PER1,ARNTL,SKP1,SERPINE1,TBL1X,CCRN4L,F7,TGS1,BTRC,CSNK1D,MEF2C
REACT_111040	Signaling by SCF-KIT	0.00950738748566085	-4.65568615250369	138	75	0.0237116661397408	3163	7167	685,1839,7249,942,2475,5894,2064,9542,1026,5578,4067,7409,5154,8651,5296,9306,5290,8503,3815,5159,64223,2241,2931,207,2249,10076,5777,867,983,2260,2246,2534,10718,4254,2932,2887,3084,27327,4318,10750,57690,27161,79109,1111,23239,6714,10019,2261,117145,5781,3717,2065,1385,6774,2242,6199,5170,2264,2254,3164,27006,5295,3845,5605,1956,2248,57761,10603,10000,26281,8817,2886,6776,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,ERBB2,NRG2,CDKN1A,PRKCA,LYN,VAV1,PDGFA,SOCS1,PIK3R2,SOCS6,PIK3CA,PIK3R3,KIT,PDGFRB,MLST8,FER,GSK3A,AKT1,FGF4,PTPRU,PTPN6,CBL,CDK1,FGFR1,FGF1,FYN,NRG3,KITLG,GSK3B,GRB10,NRG1,TNRC6A,MMP9,GRAP,TNRC6C,AGO2,MAPKAP1,CHEK1,PHLPP1,SRC,SH2B3,FGFR3,THEM4,PTPN11,JAK2,ERBB3,CREB1,STAT3,FES,RPS6KB2,PDPK1,FGFR4,FGF9,NR4A1,FGF22,PIK3R1,KRAS,MAP2K2,EGFR,FGF3,TRIB3,SH2B2,AKT3,FGF20,FGF18,GRB7,STAT5A,HRAS,CD28
REACT_19279	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.00954300518689125	-4.6519468340188	14	11	0.00347771103382864	3163	7167	91584,2534,6237,7094,5362,5361,8829,55558,2242,23396,9855	PLXNA4,FYN,RRAS,TLN1,PLXNA2,PLXNA1,NRP1,PLXNA3,FES,PIP5K1C,FARP2
REACT_6838	mTOR signalling	0.00963279726872898	-4.64258162092495	28	19	0.00600695542206766	3163	7167	5563,5564,1975,7249,2475,5565,92335,5562,55437,6009,53632,29904,57521,1981,51422,1978,6198,1977,64223	PRKAA2,PRKAB1,EIF4B,TSC2,MTOR,PRKAB2,STRADA,PRKAA1,STRADB,RHEB,PRKAG3,EEF2K,RPTOR,EIF4G1,PRKAG2,EIF4EBP1,RPS6KB1,EIF4E,MLST8
REACT_1505	Integration of energy metabolism	0.0106455505268434	-4.54261326503237	108	60	0.0189693329117926	3163	7167	5563,5313,2769,5565,6513,9254,7086,2782,5578,5566,2783,5331,6833,6945,5518,2793,2642,109,112,51764,4082,10411,6888,2771,5330,5567,1131,150,113,152,2740,777,2788,773,11069,5575,2194,107,2786,5577,26251,3710,548645,2767,3630,9630,5515,51422,291,6804,6861,114,59345,111,3708,47,3767,784,723961,5528	PRKAA2,PKLR,GNA15,PRKAB2,SLC2A1,CACNA2D2,TKT,GNB1,PRKCA,PRKACA,GNB2,PLCB3,ABCC8,MLX,PPP2R1A,GNGT2,GCGR,ADCY3,ADCY6,GNG13,MARCKS,RAPGEF3,TALDO1,GNAI2,PLCB2,PRKACB,CHRM3,ADRA2A,ADCY7,ADRA2C,GLP1R,CACNA1E,GNG7,CACNA1A,RAPGEF4,PRKAR1B,FASN,ADCY1,GNG4,PRKAR2B,KCNG2,ITPR3,DNAJC25,GNA11,INS,GNA14,PPP2CA,PRKAG2,SLC25A4,STX1A,SYT5,ADCY8,GNB4,ADCY5,ITPR1,ACLY,KCNJ11,CACNB3,INS-IGF2,PPP2R5D
REACT_12051	Cell surface interactions at the vascular wall	0.0108124839183064	-4.52705389404951	100	56	0.0177047107176731	3163	7167	2335,2207,2888,6403,57126,3635,3655,9123,6402,682,50848,2621,4067,6714,9057,140885,51744,965,6464,3675,5296,5781,5290,56301,5627,960,3687,8832,55423,2147,6404,5777,5295,3845,857,4099,481,83700,23539,3689,5335,2534,11136,2886,8140,3688,2734,5624,51378,51206,3685,9046,3897,23428,284,3265	FN1,FCER1G,GRB14,SELP,CD177,INPP5D,ITGA6,SLC16A3,SELL,BSG,F11R,GAS6,LYN,SRC,SLC7A6,SIRPA,CD244,CD58,SHC1,ITGA3,PIK3R2,PTPN11,PIK3CA,SLC7A10,PROS1,CD44,ITGAX,CD84,SIRPG,F2,SELPLG,PTPN6,PIK3R1,KRAS,CAV1,MAG,ATP1B1,JAM3,SLC16A8,ITGB2,PLCG1,FYN,SLC7A9,GRB7,SLC7A5,ITGB1,GLG1,PROC,ANGPT4,GP6,ITGAV,DOK2,L1CAM,SLC7A8,ANGPT1,HRAS
REACT_19183	CD28 co-stimulation	0.0115679631285036	-4.45951580094082	32	21	0.00663926651912741	3163	7167	5058,5170,207,942,2475,1326,5295,79109,4067,6714,7409,57761,2534,10000,117145,5296,5290,8503,9020,940,64223	PAK1,PDPK1,AKT1,CD86,MTOR,MAP3K8,PIK3R1,MAPKAP1,LYN,SRC,VAV1,TRIB3,FYN,AKT3,THEM4,PIK3R2,PIK3CA,PIK3R3,MAP3K14,CD28,MLST8
REACT_118779	Extracellular matrix organization	0.0117475975071363	-4.44410652677606	264	135	0.0426809990515334	3163	7167	4052,375790,3339,2199,5351,4327,50848,5578,63827,6382,5645,30008,4054,667,2331,3909,7448,5034,1280,1310,633,1296,1303,3689,1306,3688,649,440387,8754,5054,101,3918,2006,5479,2335,3655,1295,2192,1293,84467,650,64175,3675,4313,1291,3913,4237,1509,1298,91522,3915,23127,9672,5339,2201,1513,4324,9508,1305,1462,176,4053,1307,170690,1284,55214,27302,4921,977,7148,80781,79709,9378,84695,7373,780,3817,5154,169044,999,4146,1289,4323,22801,8515,3687,4016,3694,1311,4015,1292,1277,87,1605,83700,4326,4317,3681,140766,3911,57642,4318,1299,1508,6385,682,7042,284217,3383,3914,1504,1520,3696,6678,8751,63923,960,3672,9509,6868,10516,4811,4320,7143,9507,10536,5045,1294,826,136227,2200,5352,1515,3685,3691	LTBP1,AGRN,HSPG2,FBLN2,PLOD1,MMP19,F11R,PRKCA,BCAN,SDC1,PRSS2,EFEMP2,LTBP3,DST,FMOD,LAMA3,VTN,P4HB,COL2A1,COL19A1,BGN,COL8A2,COL12A1,ITGB2,COL15A1,ITGB1,BMP1,CTRB2,ADAM9,SERPINE1,ADAM8,LAMC2,ELN,PPIB,FN1,ITGA6,COL8A1,FBLN1,COL6A3,FBN3,BMP2,LEPRE1,ITGA3,MMP2,COL6A1,LAMB2,MFAP2,CTSD,COL9A2,COL23A1,LAMC1,COLGALT2,SDC3,PLEC,FBN2,CTSK,MMP15,ADAMTS3,COL13A1,VCAN,ACAN,LTBP2,COL16A1,ADAMTS16,COL4A2,LEPREL1,BMP10,DDR2,CD151,TNXB,COL18A1,COLGALT1,NRXN1,LOXL3,COL14A1,DDR1,KLK2,PDGFA,COL22A1,CDH1,MATN1,COL5A1,MMP14,ITGA11,ITGA10,ITGAX,LOXL1,ITGB6,COMP,LOX,COL6A2,COL1A1,ACTN1,DAG1,JAM3,MMP17,MMP8,ITGAD,ADAMTS14,LAMA5,COL20A1,MMP9,COL9A3,CTSB,SDC4,BSG,TGFB2,LAMA1,ICAM1,LAMB3,CTRB1,CTSS,ITGB8,SPARC,ADAM15,TNN,CD44,ITGA1,ADAMTS2,ADAM17,FBLN5,NID1,MMP11,TNR,ADAMTS4,LEPREL2,FURIN,COL7A1,CAPNS1,COL26A1,FBN1,PLOD2,CTSV,ITGAV,ITGB4
REACT_111217	Metabolism	0.0118584691181344	-4.43471297315934	1575	735	0.232374328169459	3163	7167	2632,2678,1588,5684,10165,57104,358,9254,51251,63827,8867,64834,3037,10841,7004,1785,1312,10411,5499,7311,7378,6609,5577,948,23539,5167,5335,226,3972,15,23417,9377,6483,3795,55066,8086,4729,5689,4329,9957,64781,81579,1345,51763,3632,23533,4018,10476,51582,1152,8694,79902,5261,1131,64087,2328,3156,4860,594,4259,9489,9807,2194,2274,8394,9517,2767,5685,1528,3931,9651,119391,255189,3708,120227,84649,166929,9440,10380,84532,43,2582,4534,1728,5313,10858,3635,55500,27158,10402,3162,5566,10560,130367,1585,1040,410,8611,8564,10213,2941,30833,9572,23171,79178,113,152,189,2597,5208,6303,107,1056,5209,55270,5515,9380,10400,51363,50486,8821,154141,5007,8566,784,2168,2584,4547,3707,4837,51141,89869,6391,80736,762,6385,1723,875,6120,2950,10654,6523,9491,100,6534,3157,10606,2232,5742,3613,3945,58478,26873,2987,2581,1807,5295,773,3939,5710,7316,2110,57761,6573,5091,5230,6804,5730,1103,79644,3098,5660,57678,10197,125061,8776,6723,1591,349565,375790,131669,133522,6256,6476,56922,445,2131,64711,2687,10423,1352,6382,2752,54905,8692,2331,56623,272,23225,6821,1646,55902,5034,5296,23446,9061,5701,60490,109,23479,633,2023,80205,9963,8612,56267,93100,4953,1743,5549,9630,9969,653689,55300,9394,4047,4800,10555,3638,1208,59345,4669,440387,5287,266722,5563,55224,1327,8702,51070,55090,7084,8771,11097,129807,8659,6945,2356,5105,5805,6548,112,191,8871,9443,5330,5686,4907,123745,56603,337876,3612,2326,8841,2181,262,7108,3295,55697,5226,5704,3423,9261,6390,2875,1548,9167,176,498,3145,5337,66002,79646,27087,65220,11112,4166,7360,58472,6513,9123,10162,23632,64900,5424,9453,51079,1592,790,6833,5164,9951,5687,3422,9441,23057,55746,55229,5336,2997,11181,26275,84188,326625,2817,2760,1491,10802,7390,25796,207,514,8021,548645,6487,5743,2645,22937,5709,126328,22908,4128,766,1716,4048,129642,6482,9955,55191,645,6716,682,285362,353,51478,375,3930,340481,64768,4056,6521,215,501,3320,960,3101,122618,3837,51144,150,3161,5692,50640,3990,5498,4758,25874,201164,81693,204219,440567,3614,9469,9536,8310,2876,6581,4712,3339,5565,27242,3949,51380,51686,2782,25942,5578,4942,2639,23175,6484,85441,1890,3631,55326,548596,2642,5290,1836,81929,55454,5160,35,2954,1841,10229,2740,2788,2271,5257,81894,79143,8399,3340,2531,81034,291,79017,1584,114,5714,649,92126,3767,3636,4594,1589,26229,2683,4697,54205,51477,113026,122622,100137049,374291,129401,2819,5298,389434,6307,471,54498,622,1503,6720,1537,2771,79888,3425,2222,9415,93010,5625,1565,130013,9926,11069,1635,5315,51129,4548,6818,55361,159,847,5699,51422,50484,1633,6861,340075,1462,8443,728294,51586,47,254531,9688,5332,6713,5224,1800,55627,2821,723961,55748,2101,37,1717,11165,10331,5321,27304,3292,6785,521,3418,7173,2783,6095,51293,5331,80308,240,1666,55256,440,9110,64428,134429,4082,5641,6888,6820,90390,2879,1350,53354,10025,26251,3710,80270,3630,122706,3248,9953,8703,166012,9612,7363,8534,7086,56894,113189,6538,5338,23396,3995,27430,1504,4695,1384,1468,5593,79603,56953,10499,1644,1464,51360,5210,55163,5096,9439,6470,29968,8509,777,56895,2786,153642,166785,9962,5834,51128,283748,6448,3033,183,2327,8560,10715,411,132,11285,10101,384,79944,4598,2180,1735,2769,29796,7358,91012,79586,60496,5696,29841,7385,3373,1610,4715,4731,4700,55588,4720,5567,10498,29956,8034,56261,6241,857,51660,51099,7179,8605,10855,8942,23305,8714,56994,5528,8720,1340,10090,84706,127281,204,50515,4726,771,435,10861,22856,79873,2109,117283,10135,84246,5211,8833,123099,516,85465,64802,5471,79071,29881,6916,345274,2629,9672,4682,5286,131870,873,23498,2224,3099,5092,6907,445329,57107,6582,6528,5721,7371,336,83549,1120,22949,79642,151056,400569,23761,5518,57834,2172,8503,2805,113451,1727,51703,55312,5333,27089,4967,27010,4521,8372,2542,210,1583,5740,406,8402,949,4713,96764,56848,5723,22934,55576,763,8760,9391,2593,8877,30,5305,2618,1159,883,3038,2793,3290,54578,51764,4728,8398,6576,6667,7296,126792,271,1455,60481,5236,151742,10243,79718,150763,5575,25830,92579,7175,80765,111,1351,55790,9218,9619	GBE1,GGT1,CYP19A1,PSMA3,SLC25A13,PNPLA2,AQP1,CACNA2D2,NT5C3A,BCAN,SYNJ1,ELOVL1,HAS2,FTCD,TEAD4,DNM2,COMT,RAPGEF3,PPP1CA,UBA52,UPP1,SMPD1,PRKAR2B,CD36,SLC16A8,ENPP1,PLCG1,ALDOA,LHB,AANAT,MLYCD,COX5A,ST3GAL2,KHK,PDPR,AAAS,NDUFV2,PSMB1,ALDH6A1,HS3ST1,CERK,PLA2G12A,COX6C,INPP5K,INPP5A,PIK3R5,LPA,ATP5H,AZIN1,CKB,DGAT1,NUP85,PHKG2,CHRM3,MCCC2,FMO3,HMGCR,PNP,BCKDHB,MGST3,PGS1,IP6K1,FASN,FHL2,PIP5K1A,SPTLC2,GNA11,PSMA4,CYB5A,LCAT,PLCH2,GSTO2,PLA2G4F,ITPR1,CYP2R1,DGAT2,SGMS2,MED17,BPNT1,ACSS1,ACHE,GALE,MTM1,NQO1,PKLR,CYP46A1,INPP5D,ETNK1,NDOR1,ST3GAL6,HMOX1,PRKACA,SLC19A2,SGPP2,CYP11B2,CDS1,ARSA,PPAP2A,KMO,PSMD14,GSTA4,NT5C,NR1D1,GPD1L,THTPA,ADCY7,ADRA2C,AGXT,GAPDH,PFKFB2,SAT1,ADCY1,CEL,PFKFB3,NUDT15,PPP2CA,GRHPR,PEMT,CHST15,G0S2,INPP4B,MBOAT1,OSBP,PDXK,CACNB3,FABP1,GALK1,MTTP,ITPKB,NNMT,INSIG2,PLCZ1,SDHC,SLC44A4,CA4,SDC4,DHODH,CBS,RPE,GSTP1,PMVK,SLC5A1,PSMF1,ADA,SLC6A7,HMGCS1,PAICS,FDXR,PTGS1,IMPA2,LDHB,ENOPH1,OPLAH,GUK1,GALC,DPYS,PIK3R1,CACNA1A,LDHA,PSMD4,UBC,ETFDH,TRIB3,SLC19A1,PC,PGK1,STX1A,PTGDS,CHAT,SRD5A3,HK1,PSAP,GPAM,PSME3,AFMID,MTMR1,SRM,CYP24A1,NMNAT3,AGRN,UROC1,PPARGC1B,RXRA,SI,MCCC1,ASS1,EXT1,HS3ST6,GGT5,CDIPT,COX10,SDC1,GLUL,CYP2W1,HYAL2,FMOD,INPP5E,AMPD3,NUP210,SUOX,AKR1C2,ACSS2,P4HB,PIK3R2,SLC44A1,PAPSS1,PSMC2,PPCDC,ADCY3,ISCU,BGN,ENO1,CHD9,SLC23A1,PPAP2C,CCBL2,NAPRT1,ODC1,DLST,PRELP,GNA14,MED13,GSTT2B,PI4K2B,HS6ST1,LSS,NFYA,AGPAT2,INSIG1,CLPS,GNB4,NAGLU,CTRB2,PIK3C2B,HS6ST3,PRKAA2,ETNK2,COX4I1,B4GALT4,NOSIP,MED9,TK2,TNFRSF6B,NUPL2,NEU4,ALDH4A1,MLX,FPGS,PCK1,PTS,SLC9A1,ADCY6,AHCY,SYNJ2,MED7,PLCB2,PSMA5,NT5E,PLA2G4E,CYP26B1,CHSY3,IMPA1,FMO1,HDAC3,ACSL3,AMD1,TM7SF2,HSD17B4,VAC14,PGD,PSMC4,IDS,MAPKAPK2,SDHB,GPT,CYP2A6,COX7A2L,ACAN,ATP5A1,HMBS,PLD1,CYP4F12,PANK3,B3GAT1,NADK,HIBADH,CHST6,UGP2,SQRDL,SLC2A1,SLC16A3,LPCAT3,CA14,LPIN3,POLD1,GGPS1,NDUFA13,CYP26A1,CAD,ABCC8,PDK2,HS3ST4,PSMA6,IDI1,MED26,NMNAT2,NUP133,PANK4,PLCG2,GYS1,TREH,HIBCH,FAR1,MMAB,GPC1,GM2A,CTH,SEC24A,UROS,PGLS,AKT1,ATP5E,NUP214,DNAJC25,ST3GAL3,PTGS2,GCK,SCAP,PSMD3,NDUFA11,SACM1L,MAOA,CA7,DGUOK,LTA4H,MBOAT2,ST3GAL1,HS3ST3A1,NADSYN1,BLVRB,SRD5A2,BSG,SUMF1,APRT,HSD17B7,ARF1,LBR,ZDHHC21,IPPK,LTC4S,SLC4A1,ABCD1,ALDH7A1,HSP90AA1,CD44,HK3,PLD4,KPNB1,HSD17B12,ADRA2A,HMMR,PSMB4,PNPLA8,LIPC,PPOX,NEU1,MPC2,PLD6,AMN,CERS3,UQCRHL,IMPDH1,CHST3,PTGES,ACOX3,GPX1,SLC22A3,NDUFB6,HSPG2,PRKAB2,TNFRSF21,LDLR,CSAD,OAZ3,GNB1,SIN3A,PRKCA,OAT,GCDH,LPIN1,ST3GAL4,HELZ2,TYMP,INPP4A,AGPAT5,CKMT1A,GCGR,PIK3CA,SLC26A2,SEH1L,CSGALNACT2,PDHA1,ACADS,GSTZ1,DTYMK,COQ7,GLP1R,GNG7,FH,PHKB,SLC25A28,MBOAT7,PLA2G10,NDST1,KDSR,SLC25A32,SLC25A4,GGCT,CYP11B1,ADCY8,PSMD8,BMP1,DSEL,KCNJ11,INPPL1,MUT,CYP21A2,B3GAT3,B4GALT1,NDUFA4,CYCS,ISYNA1,PLCD3,ADSSL1,PLA2G4B,NDUFS7,NUP35,GPD1,PI4KB,IYD,MSMO1,ATIC,SMOX,BDH1,CTPS1,SREBF1,CYC1,GNAI2,LPCAT1,IDUA,FDFT1,FADS2,B3GNT7,PRODH,CYP2D6,ACMSD,LPGAT1,RAPGEF4,DCTD,PKM,ANGPTL4,MTR,SULT1A3,PI4K2A,ADSS,CAT,PSMB10,PRKAG2,RRM2B,DCK,SYT5,ARSI,VCAN,GNPAT,D2HGDH,MED15,ACLY,LPCAT4,NUP93,PLCB4,SQLE,PGAM2,DPEP1,SMPD4,GPI,INS-IGF2,CNDP2,ESRRA,ACADVL,DHCR7,NUDT3,B3GNT3,PLA2G4A,MOCS3,HSD17B1,ELOVL4,ATP5I,IDH2,TPO,GNB2,RORA,CD320,PLCB3,FLAD1,ALOX5,DECR1,ADI1,ASNS,MTMR4,NARFL,STARD4,MARCKS,LGMN,TALDO1,SULT2B1,MED30,GPX4,COX7C,PANK1,MED16,KCNG2,ITPR3,HSD3B7,INS,PSMB11,HPGD,HS3ST3B1,B4GALT3,CHST13,NCOR2,UGT2B4,CHST1,TKT,AGPAT3,CHST14,SLC6A11,PLD2,PIP5K1C,FADS3,MAT2B,CTRB1,NDUFA2,CRAT,SLC25A10,PRKG2,CERS4,NT5M,NCOA2,DDC,CSPG4,MBTPS2,PFKFB4,PNPO,PCCB,MED23,SHMT1,PSAT1,NDST2,CACNA1E,AGPAT4,GNG4,ARSK,MMAA,SLC23A2,PYGB,SAR1B,PLA2G4D,SGSH,HADH,AGT,FMO2,DEGS1,CERS1,ARSB,ADK,B4GALT7,NUBP2,ARG2,L2HGDH,MVK,ACSL1,DIO3,GNA15,UQCR10,UGDH,CERS5,CHPF,AASDHPPT,PSMB8,GRHL1,UQCRC2,HYAL1,DAO,NDUFB9,NDUFV3,NDUFA6,MED29,NDUFS2,PRKACB,CARM1,CERS2,SLC25A16,GPCPD1,RRM2,CAV1,MPC1,ABHD5,TPTE,PLA2G4C,HPSE,KYNU,ACSL6,ABCC3,CHPT1,PPP2R5D,MBTPS1,COX6B1,UST,GPT2,FAM213B,AK2,CHST11,NDUFS6,CA12,ASL,SLC26A1,CHSY1,NUDT18,ETFB,IP6K3,NAMPT,MED10,PFKL,GMPS,DEGS2,ATP5G1,EPT1,NMNAT1,PPAT,ELOVL6,NPC1L1,TBXAS1,SLC10A6,GBA,SDC3,NUBP1,PIK3C2A,NUDT16,CBR1,HAAO,FDPS,HK2,PCBD1,TBL1X,SULT1A4,PDSS2,SLC22A2,SLC5A5,PSME2,UCK2,APOA2,UCK1,CHKB,PTGR1,ARSJ,PLB1,MED11,PISD,PPP2R1A,CYP4F11,FABP6,PIK3R3,GOT1,ADC,CYB5R3,ACSL5,RFK,PLCD1,UQCRQ,OGDH,TPK1,NUDT1,HYAL3,SLC37A4,ALAD,CYP11A1,PTGIS,ARNTL,SLC25A11,SCARB1,NDUFB7,TGS1,SPHK2,PSPH,RPIA,STAB2,CA5A,CDS2,CIAO1,GAMT,SPHK1,ACAA1,PIP4K2A,GART,CKMT1B,CCBL1,HAS3,GNGT2,HSD11B1,UGT1A6,GNG13,NDUFS8,PLA2G6,SLC25A1,SP1,TXNRD1,B3GALT6,AMPD2,CSNK1G2,ELOVL5,PGM1,PPM1L,GPHN,TBL1XR1,GPAT2,PRKAR1B,SULT4A1,G6PC3,TPR,STARD5,ADCY5,COX8A,CSGALNACT1,VAPA,ABCG1
REACT_121206	Chondroitin sulfate/dermatan sulfate metabolism	0.0120828867654262	-4.41596514437654	51	31	0.00980082200442618	3163	7167	10090,337876,126792,50515,375790,3339,6385,26229,9672,113189,22856,63827,6382,79586,3423,8372,51363,1462,55790,3373,9469,92126,633,166012,411,2817,3425,11285,27087,55454,1464	UST,CHSY3,B3GALT6,CHST11,AGRN,HSPG2,SDC4,B3GAT3,SDC3,CHST14,CHSY1,BCAN,SDC1,CHPF,IDS,HYAL3,CHST15,VCAN,CSGALNACT1,HYAL1,CHST3,DSEL,BGN,CHST13,ARSB,GPC1,IDUA,B4GALT7,B3GAT1,CSGALNACT2,CSPG4
REACT_169262	Laminin interactions	0.0122339782884431	-4.40353809285329	23	16	0.00505848877647803	3163	7167	4811,3915,3339,3655,80781,284217,3914,3909,3675,3688,3913,3685,3691,3672,3918,3911	NID1,LAMC1,HSPG2,ITGA6,COL18A1,LAMA1,LAMB3,LAMA3,ITGA3,ITGB1,LAMB2,ITGAV,ITGB4,ITGA1,LAMC2,LAMA5
REACT_111225	Regulation of KIT signaling	0.0123938058985915	-4.39055845548211	16	12	0.00379386658235852	3163	7167	10019,2534,8651,10603,5777,9306,4254,5578,867,4067,3815,6714	SH2B3,FYN,SOCS1,SH2B2,PTPN6,SOCS6,KITLG,PRKCA,CBL,LYN,KIT,SRC
REACT_25281	TRIF-mediated TLR3/TLR4 signaling	0.0141471462096879	-4.25824235652744	97	54	0.0170723996206133	3163	7167	7323,3146,7189,6195,387522,1660,8737,4205,3661,1432,9252,329,351,5606,3725,6196,3654,5518,4790,3551,5601,5781,5600,1385,6885,4791,1386,1849,29110,7311,5609,330,7867,929,1846,2353,983,5605,7316,6283,8772,9261,5515,8517,9641,23118,4792,7322,64127,23098,3665,7187,5528,4208	UBE2D3,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,RIPK1,MEF2A,IRF3,MAPK14,RPS6KA5,BIRC2,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,PTPN11,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,CD14,DUSP4,FOS,CDK1,MAP2K2,UBC,S100A12,FADD,MAPKAPK2,PPP2CA,IKBKG,IKBKE,TAB2,NFKBIA,UBE2D2,NOD2,SARM1,IRF7,TRAF3,PPP2R5D,MEF2C
REACT_6783	Toll Like Receptor 3 (TLR3) Cascade	0.0141471462096879	-4.25824235652744	97	54	0.0170723996206133	3163	7167	7323,3146,7189,6195,387522,1660,8737,4205,3661,1432,9252,329,351,5606,3725,6196,3654,5518,4790,3551,5601,5781,5600,1385,6885,4791,1386,1849,29110,7311,5609,330,7867,929,1846,2353,983,5605,7316,6283,8772,9261,5515,8517,9641,23118,4792,7322,64127,23098,3665,7187,5528,4208	UBE2D3,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,RIPK1,MEF2A,IRF3,MAPK14,RPS6KA5,BIRC2,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,PTPN11,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,CD14,DUSP4,FOS,CDK1,MAP2K2,UBC,S100A12,FADD,MAPKAPK2,PPP2CA,IKBKG,IKBKE,TAB2,NFKBIA,UBE2D2,NOD2,SARM1,IRF7,TRAF3,PPP2R5D,MEF2C
REACT_6809	MyD88-independent cascade	0.0141471462096879	-4.25824235652744	97	54	0.0170723996206133	3163	7167	7323,3146,7189,6195,387522,1660,8737,4205,3661,1432,9252,329,351,5606,3725,6196,3654,5518,4790,3551,5601,5781,5600,1385,6885,4791,1386,1849,29110,7311,5609,330,7867,929,1846,2353,983,5605,7316,6283,8772,9261,5515,8517,9641,23118,4792,7322,64127,23098,3665,7187,5528,4208	UBE2D3,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,RIPK1,MEF2A,IRF3,MAPK14,RPS6KA5,BIRC2,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,PTPN11,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,CD14,DUSP4,FOS,CDK1,MAP2K2,UBC,S100A12,FADD,MAPKAPK2,PPP2CA,IKBKG,IKBKE,TAB2,NFKBIA,UBE2D2,NOD2,SARM1,IRF7,TRAF3,PPP2R5D,MEF2C
REACT_6966	Toll-Like Receptors Cascades	0.0145197675135127	-4.23224428117974	142	76	0.0240278216882706	3163	7167	59307,81622,7189,26052,6195,387522,8737,3661,11344,1432,329,351,8411,5606,6196,5518,4790,3551,5336,1785,54106,5641,4791,1386,7100,1849,7311,330,929,57162,1846,948,983,3689,5515,8517,64145,23118,64127,3665,7187,5528,4208,7323,3146,1508,1660,4205,9252,3725,4064,1520,3654,5601,5781,5600,6885,1385,10695,29110,5609,7867,51295,246330,2353,1513,5605,8772,6283,7316,9261,9641,4792,1515,7322,23098	SIGIRR,UNC93B1,TRAF6,DNM3,RPS6KA1,TMEM189-UBE2V1,RIPK1,IRF3,TWF2,MAPK14,BIRC2,APP,EEA1,MAP2K3,RPS6KA2,PPP2R1A,NFKB1,IKBKB,PLCG2,DNM2,TLR9,LGMN,NFKB2,ATF2,TLR5,DUSP7,UBA52,BIRC3,CD14,PELI1,DUSP4,CD36,CDK1,ITGB2,PPP2CA,IKBKG,ZFYVE20,TAB2,NOD2,IRF7,TRAF3,PPP2R5D,MEF2C,UBE2D3,HMGB1,CTSB,DHX9,MEF2A,RPS6KA5,JUN,CD180,CTSS,IRAK1,MAPK9,PTPN11,MAPK11,MAP3K7,CREB1,CNPY3,TBK1,MAP2K7,MAPKAPK3,ECSIT,PELI3,FOS,CTSK,MAP2K2,FADD,S100A12,UBC,MAPKAPK2,IKBKE,NFKBIA,CTSV,UBE2D2,SARM1
REACT_12033	Signalling to RAS	0.015193902315852	-4.18686109504827	27	18	0.00569079987353778	3163	7167	7867,5894,4914,5900,3845,1432,6714,983,5605,25759,5898,9261,6464,5899,53358,5600,3265,6300	MAPKAPK3,RAF1,NTRK1,RALGDS,KRAS,MAPK14,SRC,CDK1,MAP2K2,SHC2,RALA,MAPKAPK2,SHC1,RALB,SHC3,MAPK11,HRAS,MAPK12
REACT_1190	Triglyceride Biosynthesis	0.0152334329293221	-4.18426273174156	42	26	0.00822004426177679	3163	7167	51703,60481,2180,6785,150763,79071,56895,2181,2194,56894,64900,64834,23175,2819,10555,55326,23305,47,254531,84649,57678,8694,79888,23171,51144,6576	ACSL5,ELOVL5,ACSL1,ELOVL4,GPAT2,ELOVL6,AGPAT4,ACSL3,FASN,AGPAT3,LPIN3,ELOVL1,LPIN1,GPD1,AGPAT2,AGPAT5,ACSL6,ACLY,LPCAT4,DGAT2,GPAM,DGAT1,LPCAT1,GPD1L,HSD17B12,SLC25A1
REACT_1906	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	0.0159662015998895	-4.13728119101315	8	7	0.00221308883970914	3163	7167	2147,5627,2159,2621,2155,8858,5624	F2,PROS1,F10,GAS6,F7,PROZ,PROC
REACT_11088	Nicotinate metabolism	0.0159662015998895	-4.13728119101315	8	7	0.00221308883970914	3163	7167	349565,55191,64802,23057,93100,65220,10135	NMNAT3,NADSYN1,NMNAT1,NMNAT2,NAPRT1,NADK,NAMPT
REACT_456	PKB-mediated events	0.0164924542295352	-4.10485232210013	29	19	0.00600695542206766	3163	7167	5563,5564,1975,7249,2475,5565,92335,5562,55437,6009,53632,29904,57521,1981,51422,1978,6198,1977,64223	PRKAA2,PRKAB1,EIF4B,TSC2,MTOR,PRKAB2,STRADA,PRKAA1,STRADB,RHEB,PRKAG3,EEF2K,RPTOR,EIF4G1,PRKAG2,EIF4EBP1,RPS6KB1,EIF4E,MLST8
REACT_407	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.01671249654594	-4.09159854322934	5	5	0.00158077774264938	3163	7167	1111,7465,891,995,983	CHEK1,WEE1,CCNB1,CDC25C,CDK1
REACT_115896	GRB7 events in ERBB2 signaling	0.01671249654594	-4.09159854322934	5	5	0.00158077774264938	3163	7167	2064,9542,3084,2065,2886	ERBB2,NRG2,NRG1,ERBB3,GRB7
REACT_1230	Platelet Adhesion to exposed collagen	0.0173286111649105	-4.055396318979	13	10	0.00316155548529877	3163	7167	2534,2207,3688,2812,2815,7450,51206,8515,3672,4067	FYN,FCER1G,ITGB1,GP1BB,GP9,VWF,GP6,ITGA10,ITGA1,LYN
REACT_160242	Initiation of Nuclear Envelope Reformation	0.0173286111649105	-4.055396318979	13	10	0.00316155548529877	3163	7167	221496,23141,5515,2010,4001,5518,7444,7443,4000,7112	LEMD2,ANKLE2,PPP2CA,EMD,LMNB1,PPP2R1A,VRK2,VRK1,LMNA,TMPO
REACT_160113	Nuclear Envelope Reassembly	0.0173286111649105	-4.055396318979	13	10	0.00316155548529877	3163	7167	221496,23141,5515,2010,4001,5518,7444,7443,4000,7112	LEMD2,ANKLE2,PPP2CA,EMD,LMNB1,PPP2R1A,VRK2,VRK1,LMNA,TMPO
REACT_1195	Insulin receptor signalling cascade	0.0186660035088973	-3.98105140385524	90	50	0.0158077774264938	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,25759,29904,57521,2261,6464,53358,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,983,5605,6009,3630,2260,2248,53632,2246,1981,57761,51422,3643,1978,26281,8817,2887,6198,723961,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,SHC2,EEF2K,RPTOR,FGFR3,SHC1,SHC3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,CDK1,MAP2K2,RHEB,INS,FGFR1,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,INSR,EIF4EBP1,FGF20,FGF18,GRB10,RPS6KB1,INS-IGF2,HRAS
REACT_121025	Synthesis of PIPs at the plasma membrane	0.0187387864926923	-3.97715975919426	33	21	0.00663926651912741	3163	7167	4534,3636,3635,5295,8394,8867,5305,5286,23396,55361,55300,51763,3631,23533,5296,5290,8821,8503,5287,8871,8776	MTM1,INPPL1,INPP5D,PIK3R1,PIP5K1A,SYNJ1,PIP4K2A,PIK3C2A,PIP5K1C,PI4K2A,PI4K2B,INPP5K,INPP4A,PIK3R5,PIK3R2,PIK3CA,INPP4B,PIK3R3,PIK3C2B,SYNJ2,MTMR1
REACT_20676	Cell junction organization	0.0189138226318155	-3.96786226804643	84	47	0.0148593107809042	3163	7167	1002,54751,7122,84552,3728,1495,3655,977,253559,64398,50848,23562,84612,3914,667,1007,1013,3909,999,1499,1012,5818,1364,1365,1366,2318,81607,5829,9080,7016,55679,87,5339,2316,9074,1016,6251,1006,29780,1003,3688,3691,1000,3918,9071,56288,149461	CDH4,FBLIM1,CLDN5,PARD6G,JUP,CTNNA1,ITGA6,CD151,CADM2,MPP5,F11R,CLDN14,PARD6B,LAMB3,DST,CDH9,CDH15,LAMA3,CDH1,CTNNB1,CDH13,PVRL1,CLDN4,CLDN3,CLDN7,FLNC,PVRL4,PXN,CLDN9,TESK1,LIMS2,ACTN1,PLEC,FLNA,CLDN6,CDH18,RSU1,CDH8,PARVB,CDH5,ITGB1,ITGB4,CDH2,LAMC2,CLDN10,PARD3,CLDN19
REACT_169403	Defective BTD causes biotidinase deficiency	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169313	Defective MUT causes methylmalonic aciduria mut type	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_11238	Metabolism of water-soluble vitamins and cofactors	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169439	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169178	Defective CD320 causes methylmalonic aciduria	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169385	Defects in vitamin and cofactor metabolism	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169149	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169280	Defective AMN causes hereditary megaloblastic anemia 1	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169238	Defects in biotin (Btn) metabolism	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169363	Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169169	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169316	Defective MMAA causes methylmalonic aciduria type cblA	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169429	Defects in cobalamin (B12) metabolism	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169120	Defective TCN2 causes hereditary megaloblastic anemia	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169318	Defective MMAB causes methylmalonic aciduria type cblB	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169256	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_11193	Metabolism of vitamins and cofactors	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169132	Defective CUBN causes hereditary megaloblastic anemia 1	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169312	Defective HLCS causes multiple carboxylase deficiency	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_169415	Defective GIF causes intrinsic factor deficiency	0.01897326913195	-3.96472417820364	82	46	0.0145431552323743	3163	7167	27304,349565,55191,4594,6513,56922,10560,51293,10135,80308,1504,60496,2356,23057,55229,60490,79178,326625,64087,1727,55163,5096,6470,64802,55312,10243,8034,9963,53354,2194,93100,166785,4548,1528,27010,9962,81034,6573,5167,5091,119391,81693,440387,8566,79646,65220	MOCS3,NMNAT3,NADSYN1,MUT,SLC2A1,MCCC1,SLC19A2,CD320,NAMPT,FLAD1,CTRB1,AASDHPPT,FPGS,NMNAT2,PANK4,PPCDC,THTPA,MMAB,MCCC2,CYB5R3,PNPO,PCCB,SHMT1,NMNAT1,RFK,GPHN,SLC25A16,SLC23A1,PANK1,FASN,NAPRT1,MMAA,MTR,CYB5A,TPK1,SLC23A2,SLC25A32,SLC19A1,ENPP1,PC,GSTO2,AMN,CTRB2,PDXK,PANK3,NADK
REACT_9405	Cholesterol biosynthesis	0.0197916068643134	-3.92249732689259	22	15	0.00474233322794815	3163	7167	4047,4598,3422,3157,6307,2224,7108,6713,51478,9453,1717,10654,3930,3156,2222	LSS,MVK,IDI1,HMGCS1,MSMO1,FDPS,TM7SF2,SQLE,HSD17B7,GGPS1,DHCR7,PMVK,LBR,HMGCR,FDFT1
REACT_107	Apoptotic cleavage of cellular proteins	0.0213190177330811	-3.84815575330304	39	24	0.00758773316471704	3163	7167	63967,118,839,7431,324,7082,5747,5339,1832,6304,10134,329,4000,8428,9414,2934,999,1499,4001,727758,1829,5580,6093,5317	CLSPN,ADD1,CASP6,VIM,APC,TJP1,PTK2,PLEC,DSP,SATB1,BCAP31,BIRC2,LMNA,STK24,TJP2,GSN,CDH1,CTNNB1,LMNB1,ROCK1P1,DSG2,PRKCD,ROCK1,PKP1
REACT_498	Signaling by Insulin receptor	0.0215241781463159	-3.83857841075309	113	61	0.0192854884603225	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,90423,11344,525,25759,29904,57521,533,2261,6464,53358,5296,117145,5781,5290,54106,51606,1977,9114,9550,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,983,5605,6009,2260,3630,2248,53632,2246,57761,1981,51422,3643,10312,1978,26281,8817,127124,2887,6198,527,528,723961,8992,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,ATP6V1E2,TWF2,ATP6V1B1,SHC2,EEF2K,RPTOR,ATP6V0B,FGFR3,SHC1,SHC3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,ATP6V1H,EIF4E,ATP6V0D1,ATP6V1G1,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,CDK1,MAP2K2,RHEB,FGFR1,INS,FGF3,PRKAG3,FGF1,TRIB3,EIF4G1,PRKAG2,INSR,TCIRG1,EIF4EBP1,FGF20,FGF18,ATP6V1G3,GRB10,RPS6KB1,ATP6V0C,ATP6V1C1,INS-IGF2,ATP6V0E1,HRAS
REACT_18410	Fanconi Anemia pathway	0.0236080345548078	-3.74616817765197	26	17	0.0053746443250079	3163	7167	7311,2176,672,2189,2178,2175,2188,7415,7316,2187,29089,80233,91442,27033,472,7398,545	UBA52,FANCC,BRCA1,FANCG,FANCE,FANCA,FANCF,VCP,UBC,FANCB,UBE2T,C17orf70,C19orf40,ZBTB32,ATM,USP1,ATR
REACT_21308	MAP kinase activation in TLR cascade	0.0239549094791051	-3.73158198744338	49	29	0.00916851090736642	3163	7167	7189,5609,7867,6195,4205,1846,1432,2353,9252,983,5605,5606,9261,5515,3725,8517,6196,3654,23118,5518,5601,64127,5600,1385,6885,1386,5528,1849,4208	TRAF6,MAP2K7,MAPKAPK3,RPS6KA1,MEF2A,DUSP4,MAPK14,FOS,RPS6KA5,CDK1,MAP2K2,MAP2K3,MAPKAPK2,PPP2CA,JUN,IKBKG,RPS6KA2,IRAK1,TAB2,PPP2R1A,MAPK9,NOD2,MAPK11,CREB1,MAP3K7,ATF2,PPP2R5D,DUSP7,MEF2C
REACT_21393	Regulation of Rheb GTPase activity by AMPK	0.0239636594915992	-3.73121678402519	10	8	0.00252924438823901	3163	7167	5563,5564,51422,7249,5565,6009,5562,53632	PRKAA2,PRKAB1,PRKAG2,TSC2,PRKAB2,RHEB,PRKAA1,PRKAG3
REACT_18405	Regulation of Insulin Secretion by Acetylcholine	0.0239636594915992	-3.73121678402519	10	8	0.00252924438823901	3163	7167	2769,4082,5578,5330,2767,1131,9630,5331	GNA15,MARCKS,PRKCA,PLCB2,GNA11,CHRM3,GNA14,PLCB3
REACT_23847	GP1b-IX-V activation signalling	0.0239636594915992	-3.73121678402519	10	8	0.00252924438823901	3163	7167	5894,5295,2812,2815,7450,7534,2316,6714	RAF1,PIK3R1,GP1BB,GP9,VWF,YWHAZ,FLNA,SRC
REACT_118572	Degradation of the extracellular matrix	0.0241722370104592	-3.72255053536545	89	49	0.015491621877964	3163	7167	4318,1299,3339,1508,4327,80781,682,63827,7373,5645,3817,3914,1504,3909,1520,999,4313,4323,1310,8751,1509,960,1298,6868,4320,4811,91522,3915,9507,5045,826,1513,1303,4324,136227,1305,4326,4317,1306,1515,176,649,440387,8754,101,3918,1307,3911,170690	MMP9,COL9A3,HSPG2,CTSB,MMP19,COL18A1,BSG,BCAN,COL14A1,PRSS2,KLK2,LAMB3,CTRB1,LAMA3,CTSS,CDH1,MMP2,MMP14,COL19A1,ADAM15,CTSD,CD44,COL9A2,ADAM17,MMP11,NID1,COL23A1,LAMC1,ADAMTS4,FURIN,CAPNS1,CTSK,COL12A1,MMP15,COL26A1,COL13A1,MMP17,MMP8,COL15A1,CTSV,ACAN,BMP1,CTRB2,ADAM9,ADAM8,LAMC2,COL16A1,LAMA5,ADAMTS16
REACT_995	Apoptotic execution  phase	0.0245654029005602	-3.70641621208914	53	31	0.00980082200442618	3163	7167	3146,1677,63967,118,839,7431,324,7082,5747,5339,1832,6304,10134,329,4000,8428,9414,2934,999,4001,1499,727758,10059,3005,1829,5580,3148,5317,6093,3837,3006	HMGB1,DFFB,CLSPN,ADD1,CASP6,VIM,APC,TJP1,PTK2,PLEC,DSP,SATB1,BCAP31,BIRC2,LMNA,STK24,TJP2,GSN,CDH1,LMNB1,CTNNB1,ROCK1P1,DNM1L,H1F0,DSG2,PRKCD,HMGB2,PKP1,ROCK1,KPNB1,HIST1H1C
REACT_11123	Membrane Trafficking	0.025000229830431	-3.68887026093895	195	100	0.0316155548529877	3163	7167	51552,5564,1314,5565,11316,7531,51429,8729,79058,4218,10053,57148,653653,219770,5867,4621,84062,8907,1785,55770,2707,1212,2700,10802,57165,7311,207,9698,63915,8905,3312,10717,9525,2703,10971,7163,51028,57644,10890,125111,53632,5898,22818,51160,29082,7251,128866,2580,27183,2709,84694,2702,5563,6396,23216,9026,4012,7082,23265,375,7164,9685,6714,8766,7037,9276,4074,1601,149371,22920,130340,10113,3482,5872,6643,79643,55048,51652,55330,5286,7316,51128,22872,55738,9146,51422,155382,10254,8773,11127,408,1211,7534,127534,9882,91782,8775,5878,2810,23557	RAB14,PRKAB1,COPA,PRKAB2,COPE,YWHAE,SNX9,GBF1,ASPSCR1,RAB8A,AP1M2,RALGAPB,LOC653653,GJD4,RAB4A,MYH3,DTNBP1,AP1M1,DNM2,EXOC2,GJB3,CLTB,GJA3,SEC24A,GJC2,UBA52,AKT1,PUM1,BLOC1S5,AP1S2,HSPA8,AP4B1,VPS4B,GJA8,YWHAQ,TPD52,VPS36,MYH7B,RAB10,GJD3,PRKAG3,RALA,COPZ1,VPS28,CHMP4A,TSG101,CHMP4B,GAK,VPS4A,GJB5,GJA10,GJA5,PRKAA2,SEC13,TBC1D1,HIP1R,LNPEP,TJP1,EXOC7,ARF1,TPD52L1,CLINT1,SRC,RAB11A,TFRC,COPB2,M6PR,DAB2,EXOC8,KIFAP3,AP1S3,PREB,IGF2R,RAB13,SNX2,CHMP6,VPS37C,CHMP3,BLOC1S4,PIK3C2A,UBC,SAR1B,SEC31A,ARFGAP1,HGS,PRKAG2,VPS37D,STAM2,SNAP23,KIF3A,ARRB1,CLTA,YWHAZ,GJB4,TBC1D4,CHMP7,NAPA,RAB5C,SFN,SNAPIN
REACT_6894	Toll Like Receptor 4 (TLR4) Cascade	0.0256989217399574	-3.66130624360481	120	64	0.0202339551059121	3163	7167	59307,7189,26052,6195,387522,8737,3661,1432,329,351,5606,6196,5518,4790,3551,5336,1785,4791,1386,1849,7311,330,929,57162,1846,948,983,3689,5515,8517,23118,64127,3665,7187,5528,4208,7323,3146,1660,4205,9252,3725,4064,3654,5601,5781,5600,6885,1385,29110,5609,7867,51295,246330,2353,5605,8772,6283,7316,9261,9641,4792,7322,23098	SIGIRR,TRAF6,DNM3,RPS6KA1,TMEM189-UBE2V1,RIPK1,IRF3,MAPK14,BIRC2,APP,MAP2K3,RPS6KA2,PPP2R1A,NFKB1,IKBKB,PLCG2,DNM2,NFKB2,ATF2,DUSP7,UBA52,BIRC3,CD14,PELI1,DUSP4,CD36,CDK1,ITGB2,PPP2CA,IKBKG,TAB2,NOD2,IRF7,TRAF3,PPP2R5D,MEF2C,UBE2D3,HMGB1,DHX9,MEF2A,RPS6KA5,JUN,CD180,IRAK1,MAPK9,PTPN11,MAPK11,MAP3K7,CREB1,TBK1,MAP2K7,MAPKAPK3,ECSIT,PELI3,FOS,MAP2K2,FADD,S100A12,UBC,MAPKAPK2,IKBKE,NFKBIA,UBE2D2,SARM1
REACT_75820	Class I MHC mediated antigen processing & presentation	0.0257315191676374	-3.66003861177161	263	132	0.0417325324059437	3163	7167	23291,84727,7325,5684,81559,387522,6890,55585,9666,9867,80176,64682,5696,51676,10193,51343,5701,10393,140459,55176,140739,4689,7311,10616,7704,255488,9978,3309,868,948,127544,114088,5714,7174,7320,8924,7323,51433,5689,9902,23480,26272,26118,4012,80196,63893,811,7337,2210,3107,90678,5686,6921,4591,5685,7324,5704,22872,5699,996,27338,5071,7317,23304,5721,821,4688,5687,8651,2209,10213,55294,51434,7326,64219,140460,10802,6923,991,92591,8452,140458,118424,79754,8697,23352,9021,6049,122706,8881,29927,7336,5709,23608,6500,10477,55521,6396,51665,9903,567,26270,9491,3105,1520,55070,27252,6047,11059,89910,136371,9730,7327,5692,7328,5710,7316,51128,9817,8453,1515,7322,51444,51752,93611,3685,10197,11065,401036,29945,8945,63891	FBXW11,SPSB2,UBE2E2,PSMA3,TRIM11,TMEM189-UBE2V1,TAP1,UBE2Q1,DZIP3,PJA2,SPSB1,ANAPC1,PSMB8,ASB2,RNF41,FZR1,PSMC2,ANAPC10,ASB6,SEC61A2,UBE2F,NCF4,UBA52,RBCK1,ZBTB16,RNF144B,RBX1,HSPA5,CBLB,CD36,RNF19B,TRIM9,PSMD8,TPP2,UBE2B,HERC2,UBE2D3,ANAPC5,PSMB1,MRC2,SEC61G,FBXO4,WSB1,LNPEP,RNF34,UBE2O,CALR,UBE3A,FCGR1B,HLA-C,LRSAM1,PSMA5,TCEB1,TRIM37,PSMA4,UBE2E1,PSMC4,SEC31A,PSMB10,CDC27,UBE2S,PARK2,UBA1,UBR2,PSME2,CANX,NCF2,PSMA6,SOCS1,FCGR1A,PSMD14,FBXW7,ANAPC7,UBE2G1,PJA1,ASB7,SEC24A,TCEB2,CDC20,ASB16,CUL3,ASB5,UBE2J2,ASB13,CDC23,UBR4,SOCS3,RNF6,PSMB11,CDC16,SEC61A1,UBE2V2,PSMD3,MKRN1,SKP1,UBE2E3,TRIM36,SEC13,ASB1,KLHL21,B2M,FBXO6,PSMF1,HLA-A,CTSS,DET1,KLHL20,RNF4,WWP1,UBE3B,ASB10,VPRBP,UBE2G2,PSMB4,UBE2H,PSMD4,UBC,SAR1B,KEAP1,CUL2,CTSV,UBE2D2,RNF138,ERAP1,FBXO44,ITGAV,PSME3,UBE2C,ASB18,ANAPC4,BTRC,RNF123
REACT_22232	Signaling by Interleukins	0.026386429153629	-3.63490544820845	116	62	0.0196016440088524	3163	7167	7189,3636,5894,3635,387522,1326,3606,5566,4067,1399,7409,6464,3654,8878,3572,4790,3551,5296,5781,5290,8503,3717,3557,6885,4791,6774,3556,6850,5567,4215,3562,2889,9978,5777,5295,3845,246330,3570,57162,3560,1437,867,54472,7297,29760,983,5605,9021,3554,8517,2534,23118,64127,6500,2185,3082,6776,7534,79155,3265,3567,8945	TRAF6,INPPL1,RAF1,INPP5D,TMEM189-UBE2V1,MAP3K8,IL18,PRKACA,LYN,CRKL,VAV1,SHC1,IRAK1,SQSTM1,IL6ST,NFKB1,IKBKB,PIK3R2,PTPN11,PIK3CA,PIK3R3,JAK2,IL1RN,MAP3K7,NFKB2,STAT3,IL1RAP,SYK,PRKACB,MAP3K3,IL3,RAPGEF1,RBX1,PTPN6,PIK3R1,KRAS,PELI3,IL6R,PELI1,IL2RB,CSF2,CBL,TOLLIP,TYK2,BLNK,CDK1,MAP2K2,SOCS3,IL1R1,IKBKG,FYN,TAB2,NOD2,SKP1,PTK2B,HGF,STAT5A,YWHAZ,TNIP2,HRAS,IL5,BTRC
REACT_17025	Downstream signal transduction	0.0290897595978858	-3.5373690705901	156	81	0.02560859943092	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,1399,7409,5154,5136,5296,5290,109,8503,3815,5567,5159,113,64223,2931,207,2249,4690,107,5577,3710,983,2260,2246,5335,2534,10718,114,6778,4254,2932,3084,27327,57690,27161,79109,23239,6714,2261,117145,5580,5781,112,2065,1385,6774,6199,5170,2264,2254,2889,3164,27006,5295,5575,3845,9564,5605,1956,2248,57761,111,10000,26281,2886,8817,3708,6776,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,CRKL,VAV1,PDGFA,PDE1A,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,GSK3A,AKT1,FGF4,NCK1,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,STAT6,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,MAPKAP1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,STAT3,RPS6KB2,PDPK1,FGFR4,FGF9,RAPGEF1,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,BCAR1,MAP2K2,EGFR,FGF3,TRIB3,ADCY5,AKT3,FGF20,GRB7,FGF18,ITPR1,STAT5A,HRAS,CD28
REACT_111155	Cell-Cell communication	0.0292405045797614	-3.53220038775966	131	69	0.0218147328485615	3163	7167	7122,84552,977,253559,64398,50848,1432,23562,84612,667,1007,1013,3909,999,1499,5296,1012,5818,5290,1364,55423,55243,2318,8935,9080,1630,55679,4690,5777,87,2316,9074,6251,2534,3688,81,2185,3918,9071,56288,149461,6300,1002,54751,3728,3655,1495,88,6714,140885,3914,5781,5600,9423,1365,1366,81607,5058,5829,7016,5295,5339,5747,1016,1006,29780,1003,3691,1000	CLDN5,PARD6G,CD151,CADM2,MPP5,F11R,MAPK14,CLDN14,PARD6B,DST,CDH9,CDH15,LAMA3,CDH1,CTNNB1,PIK3R2,CDH13,PVRL1,PIK3CA,CLDN4,SIRPG,KIRREL,FLNC,SKAP2,CLDN9,DCC,LIMS2,NCK1,PTPN6,ACTN1,FLNA,CLDN6,RSU1,FYN,ITGB1,ACTN4,PTK2B,LAMC2,CLDN10,PARD3,CLDN19,MAPK12,CDH4,FBLIM1,JUP,ITGA6,CTNNA1,ACTN2,SRC,SIRPA,LAMB3,PTPN11,MAPK11,NTN1,CLDN3,CLDN7,PVRL4,PAK1,PXN,TESK1,PIK3R1,PLEC,PTK2,CDH18,CDH8,PARVB,CDH5,ITGB4,CDH2
REACT_22161	Post-translational protein modification	0.0301786260868555	-3.50062135063973	211	107	0.0338286436926968	3163	7167	4248,9945,93183,5589,79695,9091,55757,821,79642,7329,84920,410,6484,50614,4585,9695,8733,5627,146712,374378,205564,144245,55650,10802,83475,2147,6612,4583,51809,90411,10610,91869,29926,6487,4122,5372,79947,4582,1650,79694,3703,57171,442117,5624,29925,727897,6483,10071,55568,117248,8703,394263,6482,140453,6396,1725,79087,4588,2683,114805,285362,80031,54344,2621,8702,5373,27090,5281,200958,811,56913,6184,4245,54872,5277,94005,10113,2650,5279,1984,93010,9761,29929,51604,374907,5329,8858,11253,11282,80267,5045,9245,64409,153642,79623,59343,51128,22872,2590,2159,6675,340075,79644,85365,411,2155,10331	MGAT3,GFPT2,PIGM,PRKCSH,GALNT12,PIGQ,UGGT2,CANX,ARSJ,UBE2I,ALG10,ARSA,ST3GAL4,GALNT9,MUC4,EDEM1,GPAA1,PROS1,B3GNTL1,GALNT18,SENP5,ALG10B,PIGV,SEC24A,DOHH,F2,SUMO3,MUC2,GALNT7,MCFD2,ST6GALNAC2,RFT1,GMPPA,ST3GAL3,MAN2A2,PMM1,DHDDS,MUC1,DDOST,MANEA,STT3A,DOLPP1,GALNTL6,PROC,GMPPB,MUC5B,ST3GAL2,MUC12,GALNT10,GALNT15,B4GALT3,MUC21,ST3GAL1,MUC17,SEC13,DHPS,ALG12,MUC6,B4GALT1,GALNT13,SUMF1,SEMA6D,DPM3,GAS6,B4GALT4,PMM2,ST6GALNAC4,PIGF,MUC20,CALR,C1GALT1,RPN1,MGAT1,PIGG,PIGA,PIGS,PREB,GCNT1,PIGC,EIF5A,B3GNT7,MLEC,ALG6,PIGT,B3GNT8,PLAUR,PROZ,MAN1B1,MGAT4B,EDEM3,FURIN,GCNT3,WBSCR17,ARSK,GALNT14,SENP2,SAR1B,SEC31A,GALNT2,F10,UAP1,ARSI,SRD5A3,ALG2,ARSB,F7,B3GNT3
REACT_120736	Signaling by FGFR in disease	0.0301801144678631	-3.50057203281122	173	89	0.028137843819159	3163	7167	685,1839,8805,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,5154,7409,5136,6464,5518,5296,5290,109,8503,3815,7750,5567,26127,5159,113,64223,7311,2931,207,2249,1523,107,5577,3710,867,983,2260,2246,5515,5335,2534,10718,114,399687,4254,2932,3084,27327,9208,57690,27161,79109,23239,6714,2261,117145,5580,5781,112,2065,1385,6774,10253,6199,613,5170,2264,2254,3164,27006,5295,5575,3845,5605,1956,7316,2248,57761,111,10000,26281,8817,3708,6776,3265,940	BTC,HBEGF,TRIM24,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,PDGFA,VAV1,PDE1A,SHC1,PPP2R1A,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,ZMYM2,PRKACB,FGFR1OP2,PDGFRB,ADCY7,MLST8,UBA52,GSK3A,AKT1,FGF4,CUX1,ADCY1,PRKAR2B,ITPR3,CBL,CDK1,FGFR1,FGF1,PPP2CA,PLCG1,FYN,NRG3,ADCY8,MYO18A,KITLG,GSK3B,NRG1,TNRC6A,LRRFIP1,TNRC6C,AGO2,MAPKAP1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,STAT3,SPRY2,RPS6KB2,BCR,PDPK1,FGFR4,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,UBC,FGF3,TRIB3,ADCY5,AKT3,FGF20,FGF18,ITPR1,STAT5A,HRAS,CD28
REACT_20625	CREB phosphorylation through the activation of Adenylate Cyclase	0.0320915884570744	-3.43916132502082	7	6	0.00189693329117926	3163	7167	109,1385,5566,114,5567,107	ADCY3,CREB1,PRKACA,ADCY8,PRKACB,ADCY1
REACT_160106	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.0320915884570744	-3.43916132502082	7	6	0.00189693329117926	3163	7167	4851,6868,3714,54567,182,28514	NOTCH1,ADAM17,JAG2,DLL4,JAG1,DLL1
REACT_6890	Activated TLR4 signalling	0.0338358617726144	-3.38623403976522	111	59	0.0186531773632627	3163	7167	7323,59307,3146,7189,6195,387522,1660,8737,4205,3661,1432,9252,329,351,5606,3725,6196,3654,5518,4790,3551,5601,5781,5600,1385,6885,4791,1386,1849,29110,7311,5609,330,7867,51295,929,246330,57162,1846,2353,948,983,5605,7316,6283,8772,9261,5515,8517,9641,23118,4792,7322,64127,23098,3665,7187,5528,4208	UBE2D3,SIGIRR,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,RIPK1,MEF2A,IRF3,MAPK14,RPS6KA5,BIRC2,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,PTPN11,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,TBK1,UBA52,MAP2K7,BIRC3,MAPKAPK3,ECSIT,CD14,PELI3,PELI1,DUSP4,FOS,CD36,CDK1,MAP2K2,UBC,S100A12,FADD,MAPKAPK2,PPP2CA,IKBKG,IKBKE,TAB2,NFKBIA,UBE2D2,NOD2,SARM1,IRF7,TRAF3,PPP2R5D,MEF2C
REACT_115871	Signaling by EGFR in Cancer	0.0343032535534837	-3.37251507352207	178	91	0.0287701549162188	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,30011,7409,5154,161,5136,6464,5296,5290,109,8503,3815,5567,5159,113,64223,7311,2931,207,2249,107,5577,3710,867,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,8874,27161,79109,29924,23239,6714,2261,117145,5580,5781,112,3320,2065,1385,10253,6199,5170,2264,2254,6868,5829,3164,27006,5295,58513,5575,3845,8038,5605,1956,7316,2248,57761,9146,10254,160,111,10000,26281,8817,3708,1211,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,SH3KBP1,VAV1,PDGFA,AP2A2,PDE1A,SHC1,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,UBA52,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CBL,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,ARHGEF7,AGO2,MAPKAP1,EPN1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,HSP90AA1,ERBB3,CREB1,SPRY2,RPS6KB2,PDPK1,FGFR4,FGF9,ADAM17,PXN,NR4A1,FGF22,PIK3R1,EPS15L1,PRKAR1B,KRAS,ADAM12,MAP2K2,EGFR,UBC,FGF3,TRIB3,HGS,STAM2,AP2A1,ADCY5,AKT3,FGF20,FGF18,ITPR1,CLTA,HRAS,CD28
REACT_9417	Signaling by EGFR	0.034909726933473	-3.35498977991031	176	90	0.0284539993676889	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,30011,7409,5154,161,5136,6464,5296,5290,109,8503,3815,5567,5159,113,64223,7311,2931,207,2249,107,5577,3710,867,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,8874,27161,79109,29924,23239,6714,2261,117145,5580,5781,112,2065,1385,10253,6199,5170,2264,2254,6868,5829,3164,27006,5295,58513,5575,3845,8038,5605,1956,7316,2248,57761,9146,10254,160,111,10000,26281,8817,3708,1211,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,SH3KBP1,VAV1,PDGFA,AP2A2,PDE1A,SHC1,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,UBA52,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CBL,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,ARHGEF7,AGO2,MAPKAP1,EPN1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,SPRY2,RPS6KB2,PDPK1,FGFR4,FGF9,ADAM17,PXN,NR4A1,FGF22,PIK3R1,EPS15L1,PRKAR1B,KRAS,ADAM12,MAP2K2,EGFR,UBC,FGF3,TRIB3,HGS,STAM2,AP2A1,ADCY5,AKT3,FGF20,FGF18,ITPR1,CLTA,HRAS,CD28
REACT_22258	Metabolism of lipids and lipoproteins	0.0374825829590784	-3.28387890832271	578	276	0.087258931394246	3163	7167	2678,1588,3339,5565,27242,57104,3949,25942,8867,64834,23175,85441,3631,55326,5290,7004,5499,35,10229,6609,948,8399,79143,2531,1584,3972,649,23417,3636,4594,1589,64781,81579,100137049,2819,51763,5298,6307,4018,23533,622,6720,8694,79888,3156,2222,9415,9489,9926,2194,2274,8394,9517,51129,55361,3931,51422,255189,340075,8443,51586,47,254531,120227,84649,6713,166929,1800,9440,55627,2101,37,1717,43,5321,3292,4534,6785,10858,3635,55500,5566,6095,130367,1585,1040,410,240,8611,1666,9110,134429,5641,9572,23171,90390,2879,1056,10025,80270,10400,50486,8821,3248,154141,5007,2168,9612,4547,51141,80736,56894,5338,10654,23396,3995,3157,1384,5742,79603,10499,51360,5096,9439,2581,56895,5295,153642,166785,51128,283748,57761,3033,183,5730,1103,79644,8560,5660,57678,10715,411,8776,1591,2180,4598,133522,6256,91012,10423,2687,6382,56623,1646,5034,29841,23446,5296,55588,10498,5567,29956,80205,56261,8612,857,9969,51099,7179,55300,4047,8605,4800,10555,3638,1208,23305,5287,8714,56994,8720,5563,127281,55224,55090,129807,84246,123099,9443,8871,123745,85465,79071,2181,29881,8841,6916,345274,2629,7108,3295,5286,55697,9261,873,2224,5337,6907,57107,336,10162,1120,22949,79642,64900,151056,9453,400569,23761,3422,9441,57834,2172,8503,84188,2760,51703,10802,5743,1583,22937,5740,406,22908,949,56848,96764,129642,4048,8760,8877,6716,285362,51478,375,30,5305,3930,4056,3290,54578,215,122618,8398,51144,3837,6576,6667,7296,1455,60481,151742,79718,150763,50640,3990,4758,80765,201164,204219,81693,9218,9536,8310,2876,9619	GGT1,CYP19A1,HSPG2,PRKAB2,TNFRSF21,PNPLA2,LDLR,SIN3A,SYNJ1,ELOVL1,LPIN1,HELZ2,INPP4A,AGPAT5,PIK3CA,TEAD4,PPP1CA,ACADS,COQ7,SMPD1,CD36,PLA2G10,MBOAT7,KDSR,CYP11B1,LHB,BMP1,MLYCD,INPPL1,MUT,CYP21A2,CERK,PLA2G12A,PLA2G4B,GPD1,INPP5K,PI4KB,MSMO1,LPA,PIK3R5,BDH1,SREBF1,DGAT1,LPCAT1,HMGCR,FDFT1,FADS2,PGS1,LPGAT1,FASN,FHL2,PIP5K1A,SPTLC2,ANGPTL4,PI4K2A,LCAT,PRKAG2,PLA2G4F,ARSI,GNPAT,MED15,ACLY,LPCAT4,CYP2R1,DGAT2,SQLE,SGMS2,DPEP1,MED17,SMPD4,ESRRA,ACADVL,DHCR7,ACHE,PLA2G4A,HSD17B1,MTM1,ELOVL4,CYP46A1,INPP5D,ETNK1,PRKACA,RORA,SGPP2,CYP11B2,CDS1,ARSA,ALOX5,PPAP2A,DECR1,MTMR4,STARD4,LGMN,NR1D1,GPD1L,MED30,GPX4,CEL,MED16,HSD3B7,PEMT,G0S2,INPP4B,HPGD,MBOAT1,OSBP,FABP1,NCOR2,MTTP,INSIG2,SLC44A4,AGPAT3,PLD2,PMVK,PIP5K1C,FADS3,HMGCS1,CRAT,PTGS1,CERS4,NCOA2,MBTPS2,PCCB,MED23,GALC,AGPAT4,PIK3R1,ARSK,MMAA,SAR1B,PLA2G4D,TRIB3,HADH,AGT,PTGDS,CHAT,SRD5A3,DEGS1,PSAP,GPAM,CERS1,ARSB,MTMR1,CYP24A1,ACSL1,MVK,PPARGC1B,RXRA,CERS5,CDIPT,GGT5,SDC1,INPP5E,AKR1C2,P4HB,GRHL1,SLC44A1,PIK3R2,MED29,CARM1,PRKACB,CERS2,CHD9,GPCPD1,PPAP2C,CAV1,MED13,ABHD5,TPTE,PI4K2B,LSS,PLA2G4C,NFYA,AGPAT2,INSIG1,CLPS,ACSL6,PIK3C2B,ABCC3,CHPT1,MBTPS1,PRKAA2,FAM213B,ETNK2,MED9,NEU4,MED10,DEGS2,MED7,SYNJ2,PLA2G4E,EPT1,ELOVL6,ACSL3,NPC1L1,HDAC3,TBXAS1,SLC10A6,GBA,TM7SF2,HSD17B4,PIK3C2A,VAC14,MAPKAPK2,CBR1,FDPS,PLD1,TBL1X,PDSS2,APOA2,LPCAT3,CHKB,PTGR1,ARSJ,LPIN3,PLB1,GGPS1,MED11,PISD,IDI1,MED26,CYP4F11,FABP6,PIK3R3,FAR1,GM2A,ACSL5,SEC24A,PTGS2,CYP11A1,SCAP,PTGIS,ARNTL,SACM1L,SCARB1,SPHK2,TGS1,MBOAT2,LTA4H,CDS2,SPHK1,SRD5A2,SUMF1,HSD17B7,ARF1,ACAA1,PIP4K2A,LBR,LTC4S,HSD11B1,UGT1A6,ABCD1,PLD4,PLA2G6,HSD17B12,KPNB1,SLC25A1,SP1,TXNRD1,CSNK1G2,ELOVL5,PPM1L,TBL1XR1,GPAT2,PNPLA8,LIPC,NEU1,STARD5,PLD6,CERS3,AMN,VAPA,PTGES,ACOX3,GPX1,ABCG1
REACT_75862	HCN channels	0.037895413979026	-3.27292517740716	4	4	0.00126462219411951	3163	7167	610,10021,348980,57657	HCN2,HCN4,HCN1,HCN3
REACT_1661	SHC activation	0.037895413979026	-3.27292517740716	4	4	0.00126462219411951	3163	7167	3643,6464,723961,3630	INSR,SHC1,INS-IGF2,INS
REACT_22365	Recycling pathway of L1	0.0379120593611814	-3.27248602855575	27	17	0.0053746443250079	3163	7167	26052,6195,285643,9252,6714,161,6196,160,1808,1785,8986,5962,1211,4478,3897,8650,57698	DNM3,RPS6KA1,KIF4B,RPS6KA5,SRC,AP2A2,RPS6KA2,AP2A1,DPYSL2,DNM2,RPS6KA4,RDX,CLTA,MSN,L1CAM,NUMB,KIAA1598
REACT_9047	Toll Like Receptor 9 (TLR9) Cascade	0.0391249278874836	-3.24099547325493	89	48	0.0151754663294341	3163	7167	3146,7189,6195,387522,1660,4205,11344,1432,9252,351,8411,5606,3725,6196,3654,5518,4790,3551,5601,5600,54106,1385,6885,4791,1386,1849,7311,5609,7867,51295,246330,57162,1846,2353,5605,983,7316,6283,5515,9261,8517,64145,23118,4792,64127,3665,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,TWF2,MAPK14,RPS6KA5,APP,EEA1,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,TLR9,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI3,PELI1,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,ZFYVE20,TAB2,NFKBIA,NOD2,IRF7,PPP2R5D,MEF2C
REACT_9020	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.0400627358040693	-3.21730865841356	85	46	0.0145431552323743	3163	7167	3146,7189,6195,387522,1660,4205,11344,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,54106,1385,6885,4791,1386,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,3665,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,TWF2,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,TLR9,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,IRF7,PPP2R5D,MEF2C
REACT_762	IRS-related events	0.0400627358040693	-3.21730865841356	85	46	0.0145431552323743	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,29904,57521,2261,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,983,5605,6009,3630,2260,2248,53632,2246,1981,57761,51422,3643,1978,26281,8817,6198,723961,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,EEF2K,RPTOR,FGFR3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,CDK1,MAP2K2,RHEB,INS,FGFR1,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,INSR,EIF4EBP1,FGF20,FGF18,RPS6KB1,INS-IGF2,HRAS
REACT_13776	p75 NTR receptor-mediated signalling	0.0400627358040693	-3.21730865841356	85	46	0.0145431552323743	3163	7167	7189,9826,22986,8874,7410,7204,57142,7531,27237,84894,7409,57449,3654,8878,23263,4790,3551,11108,9138,5664,89846,9181,7074,6453,23370,10451,6868,7311,51107,8841,1894,84033,23365,4099,11214,4804,7316,29,4792,396,121512,393,3066,64857,2245,50649	TRAF6,ARHGEF11,SORCS3,ARHGEF7,VAV2,TRIO,RTN4,YWHAE,ARHGEF16,LINGO1,VAV1,PLEKHG5,IRAK1,SQSTM1,MCF2L,NFKB1,IKBKB,PRDM4,ARHGEF1,PSEN2,FGD3,ARHGEF2,TIAM1,ITSN1,ARHGEF18,VAV3,ADAM17,UBA52,APH1A,HDAC3,ECT2,OBSCN,ARHGEF12,MAG,AKAP13,NGFR,UBC,ABR,NFKBIA,ARHGDIA,FGD4,ARHGAP4,HDAC2,PLEKHG2,FGD1,ARHGEF4
REACT_25222	MyD88 dependent cascade initiated on endosome	0.0400627358040693	-3.21730865841356	85	46	0.0145431552323743	3163	7167	3146,7189,6195,387522,1660,4205,11344,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,54106,1385,6885,4791,1386,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,3665,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,TWF2,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,TLR9,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,IRF7,PPP2R5D,MEF2C
REACT_16888	Signaling by PDGF	0.0401273361371207	-3.21569747774089	179	91	0.0287701549162188	3163	7167	685,1839,1284,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,1399,7409,5154,5136,5296,5290,109,8503,3815,5567,5159,113,64223,1292,2931,207,2249,4690,107,5577,3710,983,2260,2246,5335,2534,10718,114,6778,4254,2932,3084,27327,1299,57690,27161,79109,7059,23239,6714,1293,2261,117145,1291,5580,5781,112,2065,1385,6774,1298,6199,5170,2264,56034,2254,2889,7058,3164,27006,5295,5575,5045,3845,9564,5605,1956,2248,57761,111,10000,26281,2886,8817,3708,6776,3265,940	BTC,HBEGF,COL4A2,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,CRKL,VAV1,PDGFA,PDE1A,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,COL6A2,GSK3A,AKT1,FGF4,NCK1,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,STAT6,KITLG,GSK3B,NRG1,TNRC6A,COL9A3,TNRC6C,AGO2,MAPKAP1,THBS3,PHLPP1,SRC,COL6A3,FGFR3,THEM4,COL6A1,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,STAT3,COL9A2,RPS6KB2,PDPK1,FGFR4,PDGFC,FGF9,RAPGEF1,THBS2,NR4A1,FGF22,PIK3R1,PRKAR1B,FURIN,KRAS,BCAR1,MAP2K2,EGFR,FGF3,TRIB3,ADCY5,AKT3,FGF20,GRB7,FGF18,ITPR1,STAT5A,HRAS,CD28
REACT_25024	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.0405228171803218	-3.20589007634417	83	45	0.0142269996838445	3163	7167	3146,7189,6195,387522,1660,4205,11344,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,54106,1385,6885,4791,1386,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,TWF2,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,TLR9,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_118614	Activated NOTCH1 Transmits Signal to the Nucleus	0.0407649596751755	-3.19993239806987	31	19	0.00600695542206766	3163	7167	142678,4851,6868,7311,54567,51107,3714,54492,92737,7316,9148,182,28514,1840,5664,408,113878,8650,8788	MIB2,NOTCH1,ADAM17,UBA52,DLL4,APH1A,JAG2,NEURL1B,DNER,UBC,NEURL1,JAG1,DLL1,DTX1,PSEN2,ARRB1,DTX2,NUMB,DLK1
REACT_18325	Regulation of Insulin Secretion	0.0409753863681701	-3.19478372503318	81	44	0.0139108441353146	3163	7167	2769,6513,9254,2782,5578,5566,2783,5331,6833,2793,112,51764,4082,10411,5330,2771,5567,1131,150,152,2740,777,2788,11069,773,5575,2786,5577,26251,3710,548645,2767,9630,3630,291,6804,111,59345,6861,114,3708,3767,784,723961	GNA15,SLC2A1,CACNA2D2,GNB1,PRKCA,PRKACA,GNB2,PLCB3,ABCC8,GNGT2,ADCY6,GNG13,MARCKS,RAPGEF3,PLCB2,GNAI2,PRKACB,CHRM3,ADRA2A,ADRA2C,GLP1R,CACNA1E,GNG7,RAPGEF4,CACNA1A,PRKAR1B,GNG4,PRKAR2B,KCNG2,ITPR3,DNAJC25,GNA11,GNA14,INS,SLC25A4,STX1A,ADCY5,GNB4,SYT5,ADCY8,ITPR1,KCNJ11,CACNB3,INS-IGF2
REACT_9061	Toll Like Receptor 5 (TLR5) Cascade	0.0409753863681701	-3.19478372503318	81	44	0.0139108441353146	3163	7167	3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,7100,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,TLR5,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_9027	Toll Like Receptor 10 (TLR10) Cascade	0.0409753863681701	-3.19478372503318	81	44	0.0139108441353146	3163	7167	3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,7100,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,TLR5,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_27215	MyD88 cascade initiated on plasma membrane	0.0409753863681701	-3.19478372503318	81	44	0.0139108441353146	3163	7167	3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,7100,1849,7311,5609,7867,51295,57162,246330,1846,2353,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,TLR5,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,PELI1,PELI3,DUSP4,FOS,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_160089	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.0417079520330839	-3.17706347212057	16	11	0.00347771103382864	3163	7167	142678,4851,6868,7311,54567,182,28514,3714,54492,7316,9148	MIB2,NOTCH1,ADAM17,UBA52,DLL4,JAG1,DLL1,JAG2,NEURL1B,UBC,NEURL1
REACT_6900	Immune System	0.0430594899509566	-3.14517263219372	1191	553	0.174834018337022	3163	7167	5684,22861,71,7249,387522,9542,9666,3606,26153,613210,80176,5645,10053,8907,1785,10411,722,7100,64223,140739,7311,7704,8905,5577,948,127544,5335,64145,3984,64127,2932,6041,6725,8086,4208,81844,8924,9208,3146,5689,4794,23480,4012,1660,3725,4153,7337,8878,9447,5601,79902,83547,2889,10112,7867,4591,5685,4261,3554,1778,1667,160,3708,2212,10990,940,340061,685,26052,23304,11126,3635,8835,10096,4627,3937,5566,351,8411,6672,999,7706,10213,51434,57506,64219,140460,1386,113,4599,2931,5441,3326,107,11277,3664,56253,2260,5515,3796,5529,6049,8517,8881,29927,55718,417,6500,55521,6300,57690,7186,8672,567,29851,9491,3383,661,79132,3654,117145,27071,147700,5600,11059,2205,89910,136371,80329,3802,5170,2254,402569,2213,7128,5609,5295,1973,3570,5710,7316,5788,57761,9817,816,10000,93611,6776,3685,10197,975,8945,29945,2220,59307,81622,81559,1026,329,5606,3113,161,23225,6196,5136,1499,3572,919,5296,51517,5701,109,1977,140459,55176,718,3562,1604,4689,10616,9978,3309,868,9140,57162,4772,983,3689,114088,1981,7320,60,26118,285643,8519,11097,1154,10379,2210,112,151888,90678,5686,2264,5058,10878,27006,10892,3845,1982,10552,29760,10458,6283,5704,9261,996,5434,84166,23098,27338,5337,947,5071,920,1540,3075,1793,5137,2064,8737,4067,4688,5154,7409,5687,55845,55746,5300,3551,5336,644414,7326,503618,815,10802,79465,6923,51428,207,330,2249,7879,991,1510,92591,54941,4773,140458,118424,8021,725,2246,10718,7336,5709,2219,3082,3665,9051,1781,51665,9903,1508,1326,27161,6402,79109,375,5771,3662,5770,1520,55070,3320,960,646626,122618,9730,6850,818,3837,7327,29110,5692,10410,5591,246330,1437,8817,23308,11065,401036,3428,63891,84727,5589,8722,6890,55740,9867,5578,51728,8554,63916,10193,51676,5290,81929,1849,27040,114876,7454,7174,5714,114,1675,3688,4254,5437,11178,728358,51433,9902,3636,1958,5440,64170,7410,9493,80196,10666,129401,811,1670,10092,1509,3460,23108,11069,830,26999,1513,5605,7520,22872,5699,1378,9688,10747,3659,7189,3797,1839,79671,5894,6195,5495,2317,4179,1399,6464,2209,10628,103,54106,5641,3815,1072,8452,79754,3710,867,8697,7297,3669,817,122706,2534,1650,5525,23608,7187,3084,9474,6396,10810,5338,26270,9252,6714,3105,25,640,9436,5781,6047,2065,9020,6885,1385,10695,1512,22914,10451,4502,5747,2353,8772,733,51128,2268,51444,51752,1211,3394,613211,5724,23291,7325,942,55585,11004,1432,30011,64682,5696,653653,7448,714,51343,4790,10393,3835,81030,3556,5159,5567,4690,255488,11274,245915,245929,2185,5909,5528,27327,7323,10120,729,26272,4205,84516,23239,2688,63893,4064,973,5133,4775,84876,22920,3107,974,51295,6921,1956,2214,7324,2248,4792,10437,11127,7534,10581,10163,7317,2207,114548,2475,5721,3661,821,11344,713,8651,5518,8503,55294,3557,9103,5627,4791,4215,5777,7456,929,1846,54472,23352,9021,712,3839,23118,6778,10477,79155,4650,24145,3123,284266,2261,27252,5618,10010,51164,5580,3717,414325,130340,6774,8398,55894,6199,6868,3164,5575,7328,84265,3454,3560,972,7175,10910,925,9641,111,8453,26281,1515,7322,3265,3567	PSMA3,NLRP1,ACTG1,TSC2,TMEM189-UBE2V1,NRG2,DZIP3,IL18,KIF26A,DEFB136,SPSB1,PRSS2,AP1M2,AP1M1,DNM2,RAPGEF3,C4BPA,TLR5,MLST8,UBE2F,UBA52,ZBTB16,AP1S2,PRKAR2B,CD36,RNF19B,PLCG1,ZFYVE20,LIMK1,NOD2,GSK3B,RNASEL,SRMS,AAAS,MEF2C,TRIM56,HERC2,LRRFIP1,HMGB1,PSMB1,NFKBIE,SEC61G,LNPEP,DHX9,JUN,MBL2,UBE3A,SQSTM1,AIM2,MAPK9,NUP85,RILP,RAPGEF1,KIF20A,MAPKAPK3,TRIM37,PSMA4,CIITA,IL1R1,DYNC1H1,DEFA1,AP2A1,ITPR1,FCGR2A,LILRB5,CD28,TMEM173,BTC,DNM3,UBR2,CD160,INPP5D,SOCS2,ACTR3,MYH9,LCP2,PRKACA,APP,EEA1,SP100,CDH1,TRIM25,PSMD14,ANAPC7,MAVS,PJA1,ASB7,ATF2,ADCY7,MX1,GSK3A,POLR2L,HSP90AB1,ADCY1,TREX1,IRF6,CRTAM,FGFR1,PPP2CA,KIF2A,PPP2R5E,RNF6,IKBKG,CDC16,SEC61A1,POLR3E,ART1,SKP1,TRIM36,MAPK12,TNRC6C,TRAF2,EIF4G3,B2M,ICOS,PSMF1,ICAM1,POLR3D,DHX58,IRAK1,THEM4,DAPP1,KLC3,MAPK11,WWP1,FCER1A,UBE3B,ASB10,ULBP1,KIR2DL1,PDPK1,FGF9,KPNA7,FCGR2B,TNFAIP3,MAP2K7,PIK3R1,EIF4A1,IL6R,PSMD4,UBC,PTPRC,TRIB3,KEAP1,CAMK2B,AKT3,FBXO44,STAT5A,ITGAV,PSME3,CD81,BTRC,ANAPC4,FCN2,SIGIRR,UNC93B1,TRIM11,CDKN1A,BIRC2,MAP2K3,HLA-DPA1,AP2A2,NUP210,RPS6KA2,PDE1A,CTNNB1,IL6ST,CD247,PIK3R2,NCKIPSD,PSMC2,ADCY3,EIF4E,ASB6,SEC61A2,C3,IL3,CD55,NCF4,RBCK1,RBX1,HSPA5,CBLB,ATG12,PELI1,NFATC1,CDK1,ITGB2,TRIM9,EIF4G1,UBE2B,ACTB,WSB1,KIF4B,IFITM1,NUPL2,CISH,IRF9,FCGR1B,ADCY6,BTLA,LRSAM1,PSMA5,FGFR4,PAK1,CFHR3,FGF22,MALT1,KRAS,EIF4G2,ARPC1A,BLNK,BAIAP2,S100A12,PSMC4,MAPKAPK2,CDC27,POLR2E,NLRC5,SARM1,UBE2S,PLD1,CD34,PARK2,CD4,CYLD,CFH,DOCK1,PDE1C,ERBB2,RIPK1,LYN,NCF2,PDGFA,VAV1,PSMA6,BRK1,NUP133,PIN1,IKBKB,PLCG2,DEFB131,UBE2G1,DEFB104B,CAMK2A,SEC24A,ULBP3,TCEB2,DDX41,AKT1,BIRC3,FGF4,RAB7A,CDC20,CTSE,ASB16,RNF125,NFATC2,ASB5,UBE2J2,NUP214,C4BPB,FGF1,NRG3,UBE2V2,PSMD3,FCN1,HGF,IRF7,PSTPIP1,DYNC1I2,ASB1,KLHL21,CTSB,MAP3K8,AGO2,SELL,MAPKAP1,ARF1,PTPN2,IRF4,PTPN1,CTSS,DET1,HSP90AA1,CD44,LOC646626,PLD4,VPRBP,SYK,CAMK2G,KPNB1,UBE2G2,TBK1,PSMB4,IFITM3,PRKDC,PELI3,CSF2,FGF18,ICOSLG,UBE2C,ASB18,IFI16,RNF123,SPSB2,PRKCSH,CTSF,TAP1,ENAH,PJA2,PRKCA,POLR3K,PIAS1,ELMO2,RNF41,ASB2,PIK3CA,SEH1L,DUSP7,LAT,OSBPL1A,WAS,TPP2,PSMD8,ADCY8,CFD,ITGB1,KITLG,POLR2H,LZTS1,DEFA1B,ANAPC5,MRC2,INPPL1,EGR1,POLR2K,CARD9,VAV2,KIF23,RNF34,CD226,NUP35,CALR,DEFA5,ARPC5,CTSD,IFNGR2,RAP1GAP2,RAPGEF4,CAPZA2,CYFIP2,CTSK,MAP2K2,XRCC5,SEC31A,PSMB10,CR1,NUP93,MASP2,IRF1,TRAF6,KIF3C,HBEGF,NLRX1,RAF1,RPS6KA1,PPM1B,FLNB,CD46,CRKL,SHC1,FCGR1A,TXNIP,ADAR,TLR9,LGMN,KIT,CFL1,CUL3,ASB13,ITPR3,CBL,CDC23,TYK2,ISG20,CAMK2D,PSMB11,FYN,DDOST,PPP2R5A,MKRN1,TRAF3,NRG1,ATG5,SEC13,WASF3,PLD2,FBXO6,RPS6KA5,SRC,HLA-A,ABL1,BLK,NCR2,PTPN11,RNF4,ERBB3,MAP3K14,MAP3K7,CREB1,CNPY3,CTSH,KLRK1,VAV3,MT2A,PTK2,FOS,FADD,C8G,SAR1B,FGR,RNF138,ERAP1,CLTA,IRF8,DEFB134,PTAFR,FBXW11,UBE2E2,CD86,UBE2Q1,KIF2C,MAPK14,SH3KBP1,ANAPC1,PSMB8,LOC653653,VTN,C1QC,FZR1,NFKB1,ANAPC10,KIF22,ZBP1,IL1RAP,PDGFRB,PRKACB,NCK1,RNF144B,USP18,DEFB112,DEFB115,PTK2B,RAP1GAP,PPP2R5D,TNRC6A,UBE2D3,ACTR1B,C6,FBXO4,MEF2A,DCTN5,PHLPP1,GH1,UBE2O,CD180,CD79A,PDCD1,NFATC3,ORAI1,KIFAP3,HLA-C,CD79B,ECSIT,TCEB1,EGFR,FCGR3A,UBE2E1,FGF3,NFKBIA,IFI30,KIF3A,YWHAZ,IFITM2,WASF2,UBA1,FCER1G,NLRP3,MTOR,PSME2,IRF3,CANX,TWF2,C1QB,SOCS1,PPP2R1A,PIK3R3,FBXW7,IL1RN,FCGR2C,PROS1,NFKB2,MAP3K3,PTPN6,WIPF1,CD14,DUSP4,TOLLIP,UBR4,SOCS3,C1QA,KPNA3,TAB2,STAT6,UBE2E3,TNIP2,MYO9B,PANX1,HLA-DRB1,SIGLEC15,FGFR3,KLHL20,PRLR,TANK,DCTN4,PRKCD,JAK2,DEFB103A,AP1S3,STAT3,PLA2G6,DEFB103B,RPS6KB2,ADAM17,NR4A1,PRKAR1B,UBE2H,POLR3GL,IFNAR1,IL2RB,CD74,TPR,SUGT1,CD8A,IKBKE,ADCY5,CUL2,FGF20,CTSV,UBE2D2,HRAS,IL5
REACT_12058	Signalling to ERKs	0.0435069442209406	-3.13483471636517	37	22	0.00695542206765729	3163	7167	2889,7867,5894,4914,5900,3845,6016,1432,6714,983,5605,25759,1399,5898,9261,5335,6464,5899,53358,5600,3265,6300	RAPGEF1,MAPKAPK3,RAF1,NTRK1,RALGDS,KRAS,RIT1,MAPK14,SRC,CDK1,MAP2K2,SHC2,CRKL,RALA,MAPKAPK2,PLCG1,SHC1,RALB,SHC3,MAPK11,HRAS,MAPK12
REACT_111118	BMAL1:CLOCK/NPAS2 Activates Circadian Expression	0.0435069442209406	-3.13483471636517	37	22	0.00695542206765729	3163	7167	80205,2908,79718,8841,6256,8553,6095,8864,10135,85441,79365,5187,406,5054,1408,6907,25819,2155,96764,9572,10499,10498	CHD9,NR3C1,TBL1XR1,HDAC3,RXRA,BHLHE40,RORA,PER2,NAMPT,HELZ2,BHLHE41,PER1,ARNTL,SERPINE1,CRY2,TBL1X,CCRN4L,F7,TGS1,NR1D1,NCOA2,CARM1
REACT_121139	Collagen biosynthesis and modifying enzymes	0.0441241329363865	-3.12074841408862	65	36	0.0113815997470756	3163	7167	5479,1299,1284,55214,1295,5351,79709,80781,7373,1293,169044,64175,5034,1289,1280,1291,1310,1298,9509,1292,91522,10536,1277,1296,23127,1294,1303,136227,1305,5352,9508,1306,649,140766,1307,57642	PPIB,COL9A3,COL4A2,LEPREL1,COL8A1,PLOD1,COLGALT1,COL18A1,COL14A1,COL6A3,COL22A1,LEPRE1,P4HB,COL5A1,COL2A1,COL6A1,COL19A1,COL9A2,ADAMTS2,COL6A2,COL23A1,LEPREL2,COL1A1,COL8A2,COLGALT2,COL7A1,COL12A1,COL26A1,COL13A1,PLOD2,ADAMTS3,COL15A1,BMP1,ADAMTS14,COL16A1,COL20A1
REACT_1050	Gamma-carboxylation of protein precursors	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	2147,5627,2159,2621,2155,8858,5624	F2,PROS1,F10,GAS6,F7,PROZ,PROC
REACT_120977	Hydrolysis of LPC	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	283748,5321,8605,255189,100137049,56261,123745	PLA2G4D,PLA2G4A,PLA2G4C,PLA2G4F,PLA2G4B,GPCPD1,PLA2G4E
REACT_160251	Clearance of Nuclear Envelope Membranes from Chromatin	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	221496,2010,4001,7443,4000,7444,7112	LEMD2,EMD,LMNB1,VRK1,LMNA,VRK2,TMPO
REACT_19298	Bicarbonate transporters	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	9497,57835,6522,9498,83697,6508,6521	SLC4A7,SLC4A5,SLC4A2,SLC4A8,SLC4A9,SLC4A3,SLC4A1
REACT_22292	CHL1 interactions	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	10752,286,3672,8829,8515,3312,3688	CHL1,ANK1,ITGA1,NRP1,ITGA10,HSPA8,ITGB1
REACT_897	G2/M DNA damage checkpoint	0.044410311843497	-3.11428358778211	9	7	0.00221308883970914	3163	7167	472,545,1111,7465,891,995,983	ATM,ATR,CHEK1,WEE1,CCNB1,CDC25C,CDK1
REACT_150366	Elastic fibre formation	0.044570153694153	-3.11069084365284	41	24	0.00758773316471704	3163	7167	4052,10516,2199,27302,5045,2201,84695,7042,2192,30008,4054,84467,650,3696,7448,2200,3688,3685,4237,4053,4016,3694,2006,4015	LTBP1,FBLN5,FBLN2,BMP10,FURIN,FBN2,LOXL3,TGFB2,FBLN1,EFEMP2,LTBP3,FBN3,BMP2,ITGB8,VTN,FBN1,ITGB1,ITGAV,MFAP2,LTBP2,LOXL1,ITGB6,ELN,LOX
REACT_23787	Regulation of signaling by CBL	0.045790567361722	-3.08367716187402	18	12	0.00379386658235852	3163	7167	1399,7409,2534,2889,5296,5295,5290,8503,867,4067,29760,6850	CRKL,VAV1,FYN,RAPGEF1,PIK3R2,PIK3R1,PIK3CA,PIK3R3,CBL,LYN,BLNK,SYK
REACT_147814	DAP12 signaling	0.0480151209957606	-3.03623929693785	159	81	0.02560859943092	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,3937,5578,5566,7409,5154,5136,6464,5336,5296,5290,109,8503,3815,5567,5159,113,64223,27040,2931,207,2249,107,5577,3710,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,27161,7410,79109,567,23239,2261,117145,5580,5781,112,2065,1385,6850,22914,6199,5170,2264,10451,2254,3164,27006,5295,5575,3845,5605,1956,2248,57761,111,10000,26281,8817,3708,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,LCP2,PRKCA,PRKACA,VAV1,PDGFA,PDE1A,SHC1,PLCG2,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,LAT,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,VAV2,MAPKAP1,B2M,PHLPP1,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,SYK,KLRK1,RPS6KB2,PDPK1,FGFR4,VAV3,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,FGF3,TRIB3,ADCY5,AKT3,FGF20,FGF18,ITPR1,HRAS,CD28
REACT_118798	Pre-NOTCH Processing in Golgi	0.0491660192304103	-3.01255256015212	20	13	0.0041100221308884	3163	7167	4851,6484,3955,5986,489,5045,6400,4242,2683,4853,5870,10402,6487	NOTCH1,ST3GAL4,LFNG,RFNG,ATP2A3,FURIN,SEL1L,MFNG,B4GALT1,NOTCH2,RAB6A,ST3GAL6,ST3GAL3
REACT_474	Metabolism of carbohydrates	0.049855583293546	-2.99862478696948	266	131	0.0414163768574138	3163	7167	2632,375790,3339,10165,6476,2131,64711,63827,6382,3037,8692,79586,6484,2331,23225,9061,3373,1836,633,2023,5567,81929,55454,7311,5257,3340,5549,9394,10855,4669,226,6483,92126,5528,3795,8086,266722,10090,50515,9957,26229,2683,10861,22856,8702,129401,11097,5211,5105,6548,79902,5261,3425,337876,93010,9672,5315,5226,3423,1462,3099,176,9688,5224,2821,27087,10331,2582,4166,7360,5313,6513,10402,5566,9951,55746,5518,2997,11181,2805,6888,2817,2597,25796,5208,5209,8021,6487,5515,2542,2645,8372,51363,8402,9953,166012,8703,6482,9955,22934,55576,2584,8534,6385,7086,113189,6120,6523,3038,1468,960,3101,6576,1464,126792,3161,5210,5236,8509,92579,7316,5834,7175,6448,5091,5230,55790,9469,3098,411,11285	GBE1,AGRN,HSPG2,SLC25A13,SI,EXT1,HS3ST6,BCAN,SDC1,HAS2,HYAL2,CHPF,ST3GAL4,FMOD,NUP210,PAPSS1,HYAL1,SLC26A2,BGN,ENO1,PRKACB,SEH1L,CSGALNACT2,UBA52,PHKB,NDST1,PRELP,HS6ST1,HPSE,NAGLU,ALDOA,ST3GAL2,DSEL,PPP2R5D,KHK,AAAS,HS6ST3,UST,CHST11,HS3ST1,B3GAT3,B4GALT1,SLC26A1,CHSY1,B4GALT4,NUP35,NUPL2,PFKL,PCK1,SLC9A1,NUP85,PHKG2,IDUA,CHSY3,B3GNT7,SDC3,PKM,PGD,IDS,VCAN,HK2,ACAN,NUP93,PGAM2,GPI,B3GAT1,B3GNT3,GALE,CHST6,UGP2,PKLR,SLC2A1,ST3GAL6,PRKACA,HS3ST4,NUP133,PPP2R1A,GYS1,TREH,GOT1,TALDO1,GPC1,GAPDH,PGLS,PFKFB2,PFKFB3,NUP214,ST3GAL3,PPP2CA,SLC37A4,GCK,HYAL3,CHST15,SLC25A11,HS3ST3B1,CHST13,B4GALT3,ST3GAL1,HS3ST3A1,RPIA,STAB2,GALK1,CHST1,SDC4,TKT,CHST14,RPE,SLC5A1,HAS3,SLC25A10,CD44,HK3,SLC25A1,CSPG4,B3GALT6,HMMR,PFKFB4,PGM1,NDST2,G6PC3,UBC,PYGB,TPR,SGSH,PC,PGK1,CSGALNACT1,CHST3,HK1,ARSB,B4GALT7
REACT_2137	Mitotic Spindle Checkpoint	0.0519442284361242	-2.95758466604721	22	14	0.00442617767941827	3163	7167	64682,51433,8881,996,9184,991,10393,8379,51434,701,8697,11065,7324,29945	ANAPC1,ANAPC5,CDC16,CDC27,BUB3,CDC20,ANAPC10,MAD1L1,ANAPC7,BUB1B,CDC23,UBE2C,UBE2E1,ANAPC4
REACT_1776	Purine ribonucleoside monophosphate biosynthesis	0.0540179815182244	-2.91843829676886	11	8	0.00252924438823901	3163	7167	8833,159,3614,2618,122622,5471,471,10606	GMPS,ADSS,IMPDH1,GART,ADSSL1,PPAT,ATIC,PAICS
REACT_150182	MASTL Facilitates Mitotic Progression	0.0540179815182244	-2.91843829676886	11	8	0.00252924438823901	3163	7167	5515,5518,2029,891,10776,983,55844,84930	PPP2CA,PPP2R1A,ENSA,CCNB1,ARPP19,CDK1,PPP2R2D,MASTL
REACT_22384	Netrin mediated repulsion signals	0.0540179815182244	-2.91843829676886	11	8	0.00252924438823901	3163	7167	2534,1630,5781,5747,90249,9423,219699,6714	FYN,DCC,PTPN11,PTK2,UNC5A,NTN1,UNC5B,SRC
REACT_1132	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.0540179815182244	-2.91843829676886	11	8	0.00252924438823901	3163	7167	2147,5627,2159,2621,2155,8858,5045,5624	F2,PROS1,F10,GAS6,F7,PROZ,FURIN,PROC
REACT_6776	Unwinding of DNA	0.0540179815182244	-2.91843829676886	11	8	0.00252924438823901	3163	7167	9837,4173,51659,4174,84515,4171,84296,4172	GINS1,MCM4,GINS2,MCM5,MCM8,MCM2,GINS4,MCM3
REACT_115835	Termination of O-glycan biosynthesis	0.0542182765090094	-2.91473722241408	24	15	0.00474233322794815	3163	7167	140453,6484,4582,4585,4588,727897,4583,10071,6483,10610,394263,6482,6487,27090,200958	MUC17,ST3GAL4,MUC1,MUC4,MUC6,MUC5B,MUC2,MUC12,ST3GAL2,ST6GALNAC2,MUC21,ST3GAL1,ST3GAL3,ST6GALNAC4,MUC20
REACT_169398	Loss of Function of SMAD2/3 in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169435	Loss of Function of TGFBR2 in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169107	SMAD4 MH2 Domain Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169219	Loss of Function of SMAD4 in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169263	TGFBR1 KD Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169445	TGFBR1 LBD Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169165	SMAD2/3 MH2 Domain Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169192	TGFBR2 MSI Frameshift Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169440	TGFBR2 Kinase Domain Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169103	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_6844	Signaling by TGF-beta Receptor Complex	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169311	Loss of Function of TGFBR1 in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_169122	Signaling by TGF-beta Receptor Complex in Cancer	0.0548248374194122	-2.90361195012878	72	39	0.0123300663926652	3163	7167	7323,9612,57530,4092,7046,50848,7048,6497,2280,9110,51377,4609,3726,5499,6667,23370,7050,7311,142,5045,4221,867,7316,4088,7514,4087,56937,904,5933,25805,23645,1025,7027,5590,5054,7029,4089,56288,9958	UBE2D3,NCOR2,CGN,SMAD7,TGFBR1,F11R,TGFBR2,SKI,FKBP1A,MTMR4,UCHL5,MYC,JUNB,PPP1CA,SP1,ARHGEF18,TGIF1,UBA52,PARP1,FURIN,MEN1,CBL,UBC,SMAD3,XPO1,SMAD2,PMEPA1,CCNT1,RBL1,BAMBI,PPP1R15A,CDK9,TFDP1,PRKCZ,SERPINE1,TFDP2,SMAD4,PARD3,USP15
REACT_9470	Signaling by FGFR	0.0571015842528882	-2.86292341747059	158	80	0.0252924438823901	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,7409,5154,5136,6464,5518,5296,5290,109,8503,3815,5567,5159,113,64223,7311,2931,207,2249,107,5577,3710,867,983,2260,2246,5515,5335,2534,10718,114,4254,2932,3084,27327,57690,27161,79109,23239,6714,2261,117145,5580,5781,112,2065,1385,10253,6199,5170,2264,2254,3164,27006,5295,5575,3845,5605,1956,7316,2248,57761,111,10000,26281,8817,3708,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,VAV1,PDGFA,PDE1A,SHC1,PPP2R1A,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,UBA52,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CBL,CDK1,FGFR1,FGF1,PPP2CA,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,MAPKAP1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,SPRY2,RPS6KB2,PDPK1,FGFR4,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,UBC,FGF3,TRIB3,ADCY5,AKT3,FGF20,FGF18,ITPR1,HRAS,CD28
REACT_1069	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation	0.0575519553005777	-2.85506716870804	28	17	0.0053746443250079	3163	7167	83475,1984,2147,1725,8858,5045,285362,2621,79642,153642,410,2159,340075,5624,5627,411,2155	DOHH,EIF5A,F2,DHPS,PROZ,FURIN,SUMF1,GAS6,ARSJ,ARSK,ARSA,F10,ARSI,PROC,PROS1,ARSB,F7
REACT_21328	MAPK targets/ Nuclear events mediated by MAP kinases	0.0587301876454007	-2.83480141440087	30	18	0.00569079987353778	3163	7167	6195,4205,1846,1432,9252,2353,5515,3725,9261,6196,5518,5601,5600,1385,1386,5528,1849,4208	RPS6KA1,MEF2A,DUSP4,MAPK14,RPS6KA5,FOS,PPP2CA,JUN,MAPKAPK2,RPS6KA2,PPP2R1A,MAPK9,MAPK11,CREB1,ATF2,PPP2R5D,DUSP7,MEF2C
REACT_120906	Synthesis of PA	0.0587301876454007	-2.83480141440087	30	18	0.00569079987353778	3163	7167	5321,150763,56895,56894,5338,81579,100137049,8399,2819,283748,10555,55326,8443,254531,5337,57678,23171,79888	PLA2G4A,GPAT2,AGPAT4,AGPAT3,PLD2,PLA2G12A,PLA2G4B,PLA2G10,GPD1,PLA2G4D,AGPAT2,AGPAT5,GNPAT,LPCAT4,PLD1,GPAM,GPD1L,LPCAT1
REACT_115810	Sphingolipid de novo biosynthesis	0.0596456071075461	-2.81933477761705	32	19	0.00600695542206766	3163	7167	1455,151742,91012,8612,8877,9517,130367,2531,8611,8560,204219,166929,9218,123099,79603,5007,10715,56848,29956	CSNK1G2,PPM1L,CERS5,PPAP2C,SPHK1,SPTLC2,SGPP2,KDSR,PPAP2A,DEGS1,CERS3,SGMS2,VAPA,DEGS2,CERS4,OSBP,CERS1,SPHK2,CERS2
REACT_522	Purine metabolism	0.0603358844807779	-2.80782825306658	34	20	0.00632311097059753	3163	7167	271,4860,5471,353,122622,100,159,847,272,2618,1633,10606,471,8833,3614,30833,132,1716,2876,4907	AMPD2,PNP,PPAT,APRT,ADSSL1,ADA,ADSS,CAT,AMPD3,GART,DCK,PAICS,ATIC,GMPS,IMPDH1,NT5C,ADK,DGUOK,GPX1,NT5E
REACT_150359	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0608588409427028	-2.79919817934299	89	47	0.0148593107809042	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,25759,29904,57521,2261,6464,53358,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,983,8471,5605,6009,2260,2248,53632,2246,1981,57761,51422,1978,26281,8817,6198,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,SHC2,EEF2K,RPTOR,FGFR3,SHC1,SHC3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,CDK1,IRS4,MAP2K2,RHEB,FGFR1,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,FGF20,FGF18,RPS6KB1,HRAS
REACT_150210	IGF1R signaling cascade	0.0608588409427028	-2.79919817934299	89	47	0.0148593107809042	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,25759,29904,57521,2261,6464,53358,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,983,8471,5605,6009,2260,2248,53632,2246,1981,57761,51422,1978,26281,8817,6198,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,SHC2,EEF2K,RPTOR,FGFR3,SHC1,SHC3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,CDK1,IRS4,MAP2K2,RHEB,FGFR1,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,FGF20,FGF18,RPS6KB1,HRAS
REACT_15526	G-protein mediated events	0.0612249355317335	-2.79320072911737	46	26	0.00822004426177679	3163	7167	5321,2774,5575,5137,107,5577,5578,3710,5566,5331,5136,2781,114,111,5580,3708,346562,5332,112,2779,109,1385,2771,5330,5567,113	PLA2G4A,GNAL,PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,PLCB3,PDE1A,GNAZ,ADCY8,ADCY5,PRKCD,ITPR1,GNAT3,PLCB4,ADCY6,GNAT1,ADCY3,CREB1,GNAI2,PLCB2,PRKACB,ADCY7
REACT_163874	Non-integrin membrane-ECM interactions	0.0614108934784418	-2.79016804135013	42	24	0.00758773316471704	3163	7167	3915,375790,3339,3655,6385,4921,9672,87,9378,5578,284217,6382,780,1605,3914,5154,3909,7448,3688,3913,3685,3691,3918,3911	LAMC1,AGRN,HSPG2,ITGA6,SDC4,DDR2,SDC3,ACTN1,NRXN1,PRKCA,LAMA1,SDC1,DDR1,DAG1,LAMB3,PDGFA,LAMA3,VTN,ITGB1,LAMB2,ITGAV,ITGB4,LAMC2,LAMA5
REACT_6875	Phosphorylation of Emi1	0.0634290814180528	-2.75783282526284	6	5	0.00158077774264938	3163	7167	891,983,991,51343,26271	CCNB1,CDK1,CDC20,FZR1,FBXO5
REACT_7974	Telomere Extension By Telomerase	0.0634290814180528	-2.75783282526284	6	5	0.00158077774264938	3163	7167	55651,1736,8607,7015,55135	NHP2,DKC1,RUVBL1,TERT,WRAP53
REACT_21272	Downstream signaling of activated FGFR	0.0649951432992048	-2.73344273035184	144	73	0.023079355042681	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,7409,5154,5136,6464,5296,5290,109,8503,3815,5567,5159,113,64223,2931,207,2249,107,5577,3710,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,27161,79109,23239,2261,117145,5580,5781,112,2065,1385,6199,5170,2264,2254,3164,27006,5295,5575,3845,5605,1956,2248,57761,111,10000,26281,8817,3708,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,VAV1,PDGFA,PDE1A,SHC1,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,MAPKAP1,PHLPP1,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,CREB1,RPS6KB2,PDPK1,FGFR4,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,FGF3,TRIB3,ADCY5,AKT3,FGF20,FGF18,ITPR1,HRAS,CD28
REACT_22351	DCC mediated attractive signaling	0.0672689251996957	-2.69905688448128	15	10	0.00316155548529877	3163	7167	2534,4690,1793,1630,7204,5747,22885,9423,6714,84448	FYN,NCK1,DOCK1,DCC,TRIO,PTK2,ABLIM3,NTN1,SRC,ABLIM2
REACT_976	PI3K Cascade	0.0697598489324894	-2.66269666491573	71	38	0.0120139108441353	3163	7167	5563,5564,7249,2475,5565,92335,5562,11344,29904,57521,2261,5296,117145,5290,5781,54106,1977,64223,5170,2264,2254,1975,2249,27006,5295,55437,2260,6009,2248,53632,2246,1981,57761,51422,1978,26281,8817,6198	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,PRKAA1,TWF2,EEF2K,RPTOR,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,TLR9,EIF4E,MLST8,PDPK1,FGFR4,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,FGFR1,RHEB,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,FGF20,FGF18,RPS6KB1
REACT_22205	L1CAM interactions	0.0716317972502805	-2.63621620792253	94	49	0.015491621877964	3163	7167	26052,6195,7410,288,285643,284217,9252,6714,4897,6710,8828,161,286,6196,2048,1808,1739,1785,5962,8986,10752,6386,6900,3672,8515,5058,3915,3786,3312,214,5605,57731,1956,2260,8506,3785,160,3688,1211,51332,23114,3685,6329,8829,4478,3897,55800,8650,57698	DNM3,RPS6KA1,VAV2,ANK3,KIF4B,LAMA1,RPS6KA5,SRC,NRCAM,SPTB,NRP2,AP2A2,ANK1,RPS6KA2,EPHB2,DPYSL2,DLG1,DNM2,RDX,RPS6KA4,CHL1,SDCBP,CNTN2,ITGA1,ITGA10,PAK1,LAMC1,KCNQ3,HSPA8,ALCAM,MAP2K2,SPTBN4,EGFR,FGFR1,CNTNAP1,KCNQ2,AP2A1,ITGB1,CLTA,SPTBN5,NFASC,ITGAV,SCN4A,NRP1,MSN,L1CAM,SCN3B,NUMB,KIAA1598
REACT_15497	PKA-mediated phosphorylation of CREB	0.0717620231262081	-2.63439986867739	17	11	0.00347771103382864	3163	7167	114,111,5575,107,112,109,5577,1385,5566,5567,113	ADCY8,ADCY5,PRKAR1B,ADCY1,ADCY6,ADCY3,PRKAR2B,CREB1,PRKACA,PRKACB,ADCY7
REACT_21399	activated TAK1 mediates p38 MAPK activation	0.0717620231262081	-2.63439986867739	17	11	0.00347771103382864	3163	7167	9261,7189,8517,3654,23118,7867,64127,5600,6885,1432,5606	MAPKAPK2,TRAF6,IKBKG,IRAK1,TAB2,MAPKAPK3,NOD2,MAPK11,MAP3K7,MAPK14,MAP2K3
REACT_578	Apoptosis	0.07510789279756	-2.58882962856313	162	81	0.02560859943092	3163	7167	1677,5684,118,5721,8737,324,7531,637,10134,329,8428,23604,5687,5696,4001,999,1499,5366,5701,10213,578,7311,207,1630,10971,8743,7431,1832,2934,122706,10059,5709,5714,7132,27113,5533,6093,90249,219699,3006,4836,5689,3146,90427,63967,839,7186,54205,7082,6304,9491,4000,8837,9414,727758,1829,5580,3837,5686,6868,5692,5747,5339,5710,5685,8772,7316,1613,5704,355,5699,3005,10000,7027,356,3148,7534,317,5317,10197,2810	DFFB,PSMA3,ADD1,PSME2,RIPK1,APC,YWHAE,BID,BCAP31,BIRC2,STK24,DAPK2,PSMA6,PSMB8,LMNB1,CDH1,CTNNB1,PMAIP1,PSMC2,PSMD14,BAK1,UBA52,AKT1,DCC,YWHAQ,TNFSF10,VIM,DSP,GSN,PSMB11,DNM1L,PSMD3,PSMD8,TNFRSF1A,BBC3,PPP3CC,ROCK1,UNC5A,UNC5B,HIST1H1C,NMT1,PSMB1,HMGB1,BMF,CLSPN,CASP6,TRAF2,CYCS,TJP1,SATB1,PSMF1,LMNA,CFLAR,TJP2,ROCK1P1,DSG2,PRKCD,KPNB1,PSMA5,ADAM17,PSMB4,PTK2,PLEC,PSMD4,PSMA4,FADD,UBC,DAPK3,PSMC4,FAS,PSMB10,H1F0,AKT3,TFDP1,FASLG,HMGB2,YWHAZ,APAF1,PKP1,PSME3,SFN
REACT_12621	Tie2 Signaling	0.0752355749406043	-2.58713108887049	19	12	0.00379386658235852	3163	7167	6464,2888,5296,2886,5295,5781,5290,3845,51378,9046,284,3265	SHC1,GRB14,PIK3R2,GRB7,PIK3R1,PTPN11,PIK3CA,KRAS,ANGPT4,DOK2,ANGPT1,HRAS
REACT_121141	Signaling by FGFR1 fusion mutants	0.0752355749406043	-2.58713108887049	19	12	0.00379386658235852	3163	7167	613,9208,5335,8805,5295,399687,1523,5290,6776,7750,6774,26127	BCR,LRRFIP1,PLCG1,TRIM24,PIK3R1,MYO18A,CUX1,PIK3CA,STAT5A,ZMYM2,STAT3,FGFR1OP2
REACT_75842	Antigen processing: Ubiquitination & Proteasome degradation	0.0758959787774632	-2.57839157651815	220	108	0.0341447992412267	3163	7167	23291,5071,84727,7325,5684,7317,5721,23304,81559,387522,55585,9666,9867,80176,64682,5696,5687,8651,51676,10193,51343,5701,10393,10213,7326,51434,55294,64219,140460,140459,140739,7311,10616,6923,7704,255488,9978,991,8452,868,92591,140458,118424,8697,79754,127544,23352,9021,114088,6049,8881,122706,7336,5714,5709,7174,23608,7320,6500,10477,55521,7323,8924,51433,5689,51665,9903,26272,26118,4012,80196,26270,9491,63893,7337,55070,27252,6047,11059,89910,136371,90678,9730,5686,7327,5692,7328,6921,5710,4591,5685,7316,7324,5704,5699,9817,996,8453,7322,51444,93611,27338,10197,11065,8945,29945,401036,63891	FBXW11,PARK2,SPSB2,UBE2E2,PSMA3,UBA1,PSME2,UBR2,TRIM11,TMEM189-UBE2V1,UBE2Q1,DZIP3,PJA2,SPSB1,ANAPC1,PSMB8,PSMA6,SOCS1,ASB2,RNF41,FZR1,PSMC2,ANAPC10,PSMD14,UBE2G1,ANAPC7,FBXW7,PJA1,ASB7,ASB6,UBE2F,UBA52,RBCK1,TCEB2,ZBTB16,RNF144B,RBX1,CDC20,CUL3,CBLB,ASB16,ASB5,UBE2J2,CDC23,ASB13,RNF19B,UBR4,SOCS3,TRIM9,RNF6,CDC16,PSMB11,UBE2V2,PSMD8,PSMD3,TPP2,MKRN1,UBE2B,SKP1,UBE2E3,TRIM36,UBE2D3,HERC2,ANAPC5,PSMB1,ASB1,KLHL21,FBXO4,WSB1,LNPEP,RNF34,FBXO6,PSMF1,UBE2O,UBE3A,DET1,KLHL20,RNF4,WWP1,UBE3B,ASB10,LRSAM1,VPRBP,PSMA5,UBE2G2,PSMB4,UBE2H,TCEB1,PSMD4,TRIM37,PSMA4,UBC,UBE2E1,PSMC4,PSMB10,KEAP1,CDC27,CUL2,UBE2D2,RNF138,FBXO44,UBE2S,PSME3,UBE2C,BTRC,ANAPC4,ASB18,RNF123
REACT_1072	Inactivation of APC/C via direct inhibition of the APC/C complex	0.0779001629415122	-2.55232723443224	21	13	0.0041100221308884	3163	7167	64682,51433,8881,996,9184,991,10393,51434,701,8697,11065,7324,29945	ANAPC1,ANAPC5,CDC16,CDC27,BUB3,CDC20,ANAPC10,ANAPC7,BUB1B,CDC23,UBE2C,UBE2E1,ANAPC4
REACT_120989	Chondroitin sulfate biosynthesis	0.0779001629415122	-2.55232723443224	21	13	0.0041100221308884	3163	7167	337876,50515,1462,51363,55790,9469,633,22856,63827,166012,55454,79586,1464	CHSY3,CHST11,VCAN,CHST15,CSGALNACT1,CHST3,BGN,CHSY1,BCAN,CHST13,CSGALNACT2,CHPF,CSPG4
REACT_1041	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.0779001629415122	-2.55232723443224	21	13	0.0041100221308884	3163	7167	64682,51433,8881,996,9184,991,10393,51434,701,8697,11065,7324,29945	ANAPC1,ANAPC5,CDC16,CDC27,BUB3,CDC20,ANAPC10,ANAPC7,BUB1B,CDC23,UBE2C,UBE2E1,ANAPC4
REACT_121175	PI Metabolism	0.0793084798068957	-2.53441022280613	51	28	0.00885235535883655	3163	7167	4534,3636,3635,5295,375,8394,8867,5305,5286,55697,23396,55361,7179,56623,55300,51763,5298,3631,23533,9110,5296,8821,5290,22908,8503,5287,8871,8776	MTM1,INPPL1,INPP5D,PIK3R1,ARF1,PIP5K1A,SYNJ1,PIP4K2A,PIK3C2A,VAC14,PIP5K1C,PI4K2A,TPTE,INPP5E,PI4K2B,INPP5K,PI4KB,INPP4A,PIK3R5,MTMR4,PIK3R2,INPP4B,PIK3CA,SACM1L,PIK3R3,PIK3C2B,SYNJ2,MTMR1
REACT_332	IRS-mediated signalling	0.079437116729467	-2.53278955485018	82	43	0.0135946885867847	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,29904,57521,2261,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,5605,983,2260,6009,2248,53632,2246,1981,57761,51422,1978,26281,8817,6198,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,EEF2K,RPTOR,FGFR3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,MAP2K2,CDK1,FGFR1,RHEB,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,FGF20,FGF18,RPS6KB1,HRAS
REACT_23837	Interleukin-3, 5 and GM-CSF signaling	0.0801257473623157	-2.52415803633001	49	27	0.00853619981030667	3163	7167	3562,3636,2889,5777,3635,5295,3560,1437,867,5566,4067,29760,1399,7409,2534,6464,5296,5290,5781,8503,3717,6776,7534,6850,3265,3567,5567	IL3,INPPL1,RAPGEF1,PTPN6,INPP5D,PIK3R1,IL2RB,CSF2,CBL,PRKACA,LYN,BLNK,CRKL,VAV1,FYN,SHC1,PIK3R2,PIK3CA,PTPN11,PIK3R3,JAK2,STAT5A,YWHAZ,SYK,HRAS,IL5,PRKACB
REACT_1859	Pentose phosphate pathway (hexose monophosphate shunt)	0.0804677490290674	-2.51989880801182	8	6	0.00189693329117926	3163	7167	6888,6120,25796,5226,22934,7086	TALDO1,RPE,PGLS,PGD,RPIA,TKT
REACT_22357	Organic cation transport	0.0804677490290674	-2.51989880801182	8	6	0.00189693329117926	3163	7167	6582,6581,6583,5002,85413,6584	SLC22A2,SLC22A3,SLC22A4,SLC22A18,SLC22A16,SLC22A5
REACT_121280	Synthesis of PG	0.0804677490290674	-2.51989880801182	8	6	0.00189693329117926	3163	7167	5338,8760,5337,122618,201164,9489	PLD2,CDS2,PLD1,PLD4,PLD6,PGS1
REACT_11202	Vitamin C (ascorbate) metabolism	0.0804677490290674	-2.51989880801182	8	6	0.00189693329117926	3163	7167	119391,9963,1528,6513,1727,9962	GSTO2,SLC23A1,CYB5A,SLC2A1,CYB5R3,SLC23A2
REACT_13815	Axonal growth inhibition (RHOA activation)	0.0804677490290674	-2.51989880801182	8	6	0.00189693329117926	3163	7167	57142,4099,4804,9138,396,84894	RTN4,MAG,NGFR,ARHGEF1,ARHGDIA,LINGO1
REACT_1698	Metabolism of nucleotides	0.0808045774137851	-2.515721663899	80	42	0.0132785330382548	3163	7167	204,7371,83549,1723,353,51251,79873,122622,100,7084,790,272,1890,2618,471,10606,1503,8833,30833,56953,4907,7296,271,1841,4860,2987,5471,7378,1807,6241,1635,55270,159,847,4521,131870,50484,1633,3614,132,1716,2876	AK2,UCK2,UCK1,DHODH,APRT,NT5C3A,NUDT18,ADSSL1,ADA,TK2,CAD,AMPD3,TYMP,GART,ATIC,PAICS,CTPS1,GMPS,NT5C,NT5M,NT5E,TXNRD1,AMPD2,DTYMK,PNP,GUK1,PPAT,UPP1,DPYS,RRM2,DCTD,NUDT15,ADSS,CAT,NUDT1,NUDT16,RRM2B,DCK,IMPDH1,ADK,DGUOK,GPX1
REACT_6820	APC/C:Cdc20 mediated degradation of Cyclin B	0.0814079224304548	-2.50828268355416	25	15	0.00474233322794815	3163	7167	64682,51433,8881,7311,996,991,10393,51434,891,8697,11065,983,7324,7316,29945	ANAPC1,ANAPC5,CDC16,UBA52,CDC27,CDC20,ANAPC10,ANAPC7,CCNB1,CDC23,UBE2C,CDK1,UBE2E1,UBC,ANAPC4
REACT_21391	Mitotic G2-G2/M phases	0.081412141559273	-2.50823085789194	120	61	0.0192854884603225	3163	7167	22995,23291,1781,22919,5116,80321,4659,10383,1063,891,7531,984,5566,132660,22897,286826,1069,7465,4218,5518,80184,85378,4751,10733,994,3320,80254,10426,7277,993,7311,902,1454,55755,114791,1871,4605,5577,9088,22994,995,983,7316,5515,1778,4926,7514,11190,22981,4957,10806,8481,55722,4660,6500,8636,55125,54820,1453,8945,55957	CEP152,FBXW11,DYNC1I2,MAPRE1,PCNT,CEP70,PPP1R12A,TUBB4B,CENPF,CCNB1,YWHAE,CDK11B,PRKACA,LIN54,CEP164,LIN9,CETN2,WEE1,RAB8A,PPP2R1A,CEP290,TUBGCP6,NEK2,PLK4,CDC25B,HSP90AA1,CEP63,TUBGCP3,TUBA4A,CDC25A,UBA52,CCNH,CSNK1E,CDK5RAP2,TUBGCP5,E2F3,MYBL2,PRKAR2B,PKMYT1,AZI1,CDC25C,CDK1,UBC,PPP2CA,DYNC1H1,NUMA1,XPO1,CEP250,NINL,ODF2,SDCCAG8,OFD1,CEP72,PPP1R12B,SKP1,SSNA1,CEP192,NDE1,CSNK1D,BTRC,LIN37
REACT_75908	Potassium Channels	0.0814756574546242	-2.50745098488789	101	52	0.0164400885235536	3163	7167	3779,27012,9196,89822,3754,3763,2782,10021,3777,3749,3766,2783,3737,6833,3756,3781,7881,2793,3783,83795,3776,8514,57657,3768,51305,3786,3759,9568,3778,2788,2786,3746,610,3752,3784,26251,3757,548645,3785,3762,3765,170850,3775,3755,3782,3780,3788,3767,3739,348980,9424,10089	KCNMB1,KCNV1,KCNAB3,KCNK17,KCNF1,KCNJ6,GNB1,HCN4,KCNK3,KCNC4,KCNJ10,GNB2,KCNA2,ABCC8,KCNH1,KCNN2,KCNAB1,GNGT2,KCNN4,KCNK16,KCNK2,KCNAB2,HCN3,KCNJ12,KCNK9,KCNQ3,KCNJ2,GABBR2,KCNMA1,GNG7,GNG4,KCNC1,HCN2,KCND3,KCNQ1,KCNG2,KCNH2,DNAJC25,KCNQ2,KCNJ5,KCNJ9,KCNG3,KCNK1,KCNG1,KCNN3,KCNN1,KCNS2,KCNJ11,KCNA4,HCN1,KCNK6,KCNK7
REACT_13638	NRAGE signals death through JNK	0.0816006021879684	-2.50591863728479	45	25	0.00790388871324692	3163	7167	23370,10451,9826,8874,7410,7204,1894,84033,23365,11214,4804,27237,29,7409,57449,23263,89846,121512,9181,393,7074,6453,64857,50649,2245	ARHGEF18,VAV3,ARHGEF11,ARHGEF7,VAV2,TRIO,ECT2,OBSCN,ARHGEF12,AKAP13,NGFR,ARHGEF16,ABR,VAV1,PLEKHG5,MCF2L,FGD3,FGD4,ARHGEF2,ARHGAP4,TIAM1,ITSN1,PLEKHG2,ARHGEF4,FGD1
REACT_15426	PLC beta mediated events	0.0816006021879684	-2.50591863728479	45	25	0.00790388871324692	3163	7167	5321,5575,5137,107,5577,5578,3710,5566,5331,5136,2781,114,111,5580,3708,346562,5332,2779,112,109,1385,2771,5330,5567,113	PLA2G4A,PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,PLCB3,PDE1A,GNAZ,ADCY8,ADCY5,PRKCD,ITPR1,GNAT3,PLCB4,GNAT1,ADCY6,ADCY3,CREB1,GNAI2,PLCB2,PRKACB,ADCY7
REACT_2203	G2/M Transition	0.0829726081535991	-2.48924474790066	118	60	0.0189693329117926	3163	7167	22995,1781,23291,22919,5116,4659,80321,10383,1063,984,7531,891,5566,132660,22897,286826,4218,7465,1069,5518,80184,85378,10733,4751,3320,80254,994,10426,7277,993,7311,902,1454,55755,114791,4605,5577,9088,22994,995,983,7316,4926,1778,5515,7514,11190,22981,4957,10806,8481,4660,55722,6500,8636,55125,54820,8945,1453,55957	CEP152,DYNC1I2,FBXW11,MAPRE1,PCNT,PPP1R12A,CEP70,TUBB4B,CENPF,CDK11B,YWHAE,CCNB1,PRKACA,LIN54,CEP164,LIN9,RAB8A,WEE1,CETN2,PPP2R1A,CEP290,TUBGCP6,PLK4,NEK2,HSP90AA1,CEP63,CDC25B,TUBGCP3,TUBA4A,CDC25A,UBA52,CCNH,CSNK1E,CDK5RAP2,TUBGCP5,MYBL2,PRKAR2B,PKMYT1,AZI1,CDC25C,CDK1,UBC,NUMA1,DYNC1H1,PPP2CA,XPO1,CEP250,NINL,ODF2,SDCCAG8,OFD1,PPP1R12B,CEP72,SKP1,SSNA1,CEP192,NDE1,BTRC,CSNK1D,LIN37
REACT_19259	Sema4D in semaphorin signaling	0.0831836838987609	-2.48670405737251	29	17	0.0053746443250079	3163	7167	391,5880,6237,10507,9826,727758,3984,389,2064,4627,23365,6093,4233,4628,103910,388,5364	RHOG,RAC2,RRAS,SEMA4D,ARHGEF11,ROCK1P1,LIMK1,RHOC,ERBB2,MYH9,ARHGEF12,ROCK1,MET,MYH10,MYL12B,RHOB,PLXNB1
REACT_120850	TGF-beta receptor signaling activates SMADs	0.0837850129024836	-2.47950113113431	33	19	0.00600695542206766	3163	7167	7311,5045,4092,7046,867,7048,7316,4088,2280,4087,7514,56937,9110,25805,51377,23645,5499,4089,9958	UBA52,FURIN,SMAD7,TGFBR1,CBL,TGFBR2,UBC,SMAD3,FKBP1A,SMAD2,XPO1,PMEPA1,MTMR4,BAMBI,UCHL5,PPP1R15A,PPP1CA,SMAD4,USP15
REACT_118721	Signaling by NOTCH2	0.0837850129024836	-2.47950113113431	33	19	0.00600695542206766	3163	7167	142678,3280,7311,54567,51107,4853,3714,54492,7316,9148,4192,182,28514,10046,5664,388585,3516,9794,1385	MIB2,HES1,UBA52,DLL4,APH1A,NOTCH2,JAG2,NEURL1B,UBC,NEURL1,MDK,JAG1,DLL1,MAMLD1,PSEN2,HES5,RBPJ,MAML1,CREB1
REACT_15296	Recruitment of mitotic centrosome proteins and complexes	0.0850146576213733	-2.46493159475395	74	39	0.0123300663926652	3163	7167	22995,1781,22919,5116,80321,10383,984,7531,891,5566,22897,1069,5518,80184,85378,10733,4751,3320,80254,10426,7277,1454,55755,114791,5577,22994,983,1778,4926,11190,22981,10806,4957,8481,55722,8636,55125,54820,1453	CEP152,DYNC1I2,MAPRE1,PCNT,CEP70,TUBB4B,CDK11B,YWHAE,CCNB1,PRKACA,CEP164,CETN2,PPP2R1A,CEP290,TUBGCP6,PLK4,NEK2,HSP90AA1,CEP63,TUBGCP3,TUBA4A,CSNK1E,CDK5RAP2,TUBGCP5,PRKAR2B,AZI1,CDK1,DYNC1H1,NUMA1,CEP250,NINL,SDCCAG8,ODF2,OFD1,CEP72,SSNA1,CEP192,NDE1,CSNK1D
REACT_15479	Centrosome maturation	0.0850146576213733	-2.46493159475395	74	39	0.0123300663926652	3163	7167	22995,1781,22919,5116,80321,10383,984,7531,891,5566,22897,1069,5518,80184,85378,10733,4751,3320,80254,10426,7277,1454,55755,114791,5577,22994,983,1778,4926,11190,22981,10806,4957,8481,55722,8636,55125,54820,1453	CEP152,DYNC1I2,MAPRE1,PCNT,CEP70,TUBB4B,CDK11B,YWHAE,CCNB1,PRKACA,CEP164,CETN2,PPP2R1A,CEP290,TUBGCP6,PLK4,NEK2,HSP90AA1,CEP63,TUBGCP3,TUBA4A,CSNK1E,CDK5RAP2,TUBGCP5,PRKAR2B,AZI1,CDK1,DYNC1H1,NUMA1,CEP250,NINL,SDCCAG8,ODF2,OFD1,CEP72,SSNA1,CEP192,NDE1,CSNK1D
REACT_75774	Adaptive Immune System	0.0854544115358511	-2.45977224365134	648	303	0.0957951312045526	3163	7167	84727,5684,7249,8722,387522,6890,9542,9666,55740,9867,26153,80176,10053,51676,10193,5290,8907,1785,10411,64223,140739,27040,7311,7704,8905,948,127544,114876,5335,7454,5714,7174,3688,4254,2932,6725,8924,51433,5689,9902,4794,23480,4012,9493,80196,10666,811,7337,1509,83547,10112,11069,23108,1513,4591,5685,22872,1778,5699,160,3708,10990,940,685,7189,3797,1839,26052,23304,11126,3635,5894,3937,5566,6464,999,2209,10213,51434,64219,5641,140460,3815,2931,8452,8697,56253,79754,3710,867,2260,3796,5515,5529,6049,8517,2534,8881,122706,5525,29927,23608,6500,3084,55521,6396,57690,567,26270,29851,6714,9491,3383,3105,640,117145,27071,147700,5781,6047,11059,89910,2065,1385,6885,9020,136371,1512,22914,80329,3802,5170,2254,2213,5295,5710,7316,51128,5788,57761,9817,10000,51444,51752,1211,93611,3685,10197,975,8945,29945,23291,7325,942,81559,55585,11004,1026,30011,3113,64682,161,5696,653653,919,4790,51343,5701,5296,10393,3835,140459,5567,5159,55176,718,10616,4689,9978,255488,4690,3309,868,114088,3689,7320,5909,5528,27327,7323,10120,26272,26118,285643,84516,23239,8519,63893,5133,973,2210,84876,22920,151888,3107,90678,5686,5058,2264,27006,974,10892,6921,3845,29760,1956,7324,2214,2248,5704,996,4792,11127,10437,7534,27338,947,5071,920,7317,2475,5721,2064,821,4067,4688,5154,7409,5687,8651,5518,5336,3551,8503,55294,7326,9103,10802,79465,207,6923,2249,7879,5777,1510,991,92591,140458,118424,23352,9021,2246,10718,23118,7336,5709,10477,51665,1781,9903,1508,27161,1326,79109,6402,375,3123,2261,1520,55070,27252,51164,646626,130340,6850,9730,7327,6199,5692,3164,7328,972,925,8453,26281,8817,1515,7322,23308,11065,3265,401036,63891	SPSB2,PSMA3,TSC2,CTSF,TMEM189-UBE2V1,TAP1,NRG2,DZIP3,ENAH,PJA2,KIF26A,SPSB1,AP1M2,ASB2,RNF41,PIK3CA,AP1M1,DNM2,RAPGEF3,MLST8,UBE2F,LAT,UBA52,ZBTB16,AP1S2,CD36,RNF19B,OSBPL1A,PLCG1,WAS,PSMD8,TPP2,ITGB1,KITLG,GSK3B,SRMS,HERC2,ANAPC5,PSMB1,MRC2,NFKBIE,SEC61G,LNPEP,KIF23,RNF34,CD226,CALR,UBE3A,CTSD,RILP,KIF20A,RAPGEF4,RAP1GAP2,CTSK,TRIM37,PSMA4,SEC31A,DYNC1H1,PSMB10,AP2A1,ITPR1,LILRB5,CD28,BTC,TRAF6,KIF3C,HBEGF,DNM3,UBR2,CD160,INPP5D,RAF1,LCP2,PRKACA,SHC1,CDH1,FCGR1A,PSMD14,ANAPC7,PJA1,LGMN,ASB7,KIT,GSK3A,CUL3,CDC23,CRTAM,ASB13,ITPR3,CBL,FGFR1,KIF2A,PPP2CA,PPP2R5E,RNF6,IKBKG,FYN,CDC16,PSMB11,PPP2R5A,SEC61A1,MKRN1,SKP1,NRG1,TRIM36,SEC13,TNRC6C,B2M,FBXO6,ICOS,SRC,PSMF1,ICAM1,HLA-A,BLK,THEM4,DAPP1,KLC3,PTPN11,RNF4,WWP1,UBE3B,ERBB3,CREB1,MAP3K7,MAP3K14,ASB10,CTSH,KLRK1,ULBP1,KIR2DL1,PDPK1,FGF9,FCGR2B,PIK3R1,PSMD4,UBC,SAR1B,PTPRC,TRIB3,KEAP1,AKT3,RNF138,ERAP1,CLTA,FBXO44,ITGAV,PSME3,CD81,BTRC,ANAPC4,FBXW11,UBE2E2,CD86,TRIM11,UBE2Q1,KIF2C,CDKN1A,SH3KBP1,HLA-DPA1,ANAPC1,AP2A2,PSMB8,LOC653653,CD247,NFKB1,FZR1,PSMC2,PIK3R2,ANAPC10,KIF22,ASB6,PRKACB,PDGFRB,SEC61A2,C3,RBCK1,NCF4,RBX1,RNF144B,NCK1,HSPA5,CBLB,TRIM9,ITGB2,UBE2B,RAP1GAP,PPP2R5D,TNRC6A,UBE2D3,ACTR1B,FBXO4,WSB1,KIF4B,DCTN5,PHLPP1,IFITM1,UBE2O,PDCD1,CD79A,FCGR1B,ORAI1,KIFAP3,BTLA,HLA-C,LRSAM1,PSMA5,PAK1,FGFR4,FGF22,CD79B,MALT1,TCEB1,KRAS,BLNK,EGFR,UBE2E1,FCGR3A,FGF3,PSMC4,CDC27,NFKBIA,KIF3A,IFI30,YWHAZ,UBE2S,CD34,PARK2,CD4,UBA1,MTOR,PSME2,ERBB2,CANX,LYN,NCF2,PDGFA,VAV1,PSMA6,SOCS1,PPP2R1A,PLCG2,IKBKB,PIK3R3,FBXW7,UBE2G1,FCGR2C,SEC24A,ULBP3,AKT1,TCEB2,FGF4,RAB7A,PTPN6,CTSE,CDC20,ASB16,ASB5,UBE2J2,UBR4,SOCS3,FGF1,NRG3,TAB2,UBE2V2,PSMD3,UBE2E3,ASB1,DYNC1I2,KLHL21,CTSB,AGO2,MAP3K8,MAPKAP1,SELL,ARF1,HLA-DRB1,FGFR3,CTSS,DET1,KLHL20,DCTN4,LOC646626,AP1S3,SYK,VPRBP,UBE2G2,RPS6KB2,PSMB4,NR4A1,UBE2H,CD74,CD8A,CUL2,FGF20,FGF18,CTSV,UBE2D2,ICOSLG,UBE2C,HRAS,ASB18,RNF123
REACT_75779	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.0859122613106339	-2.45442872082276	3	3	0.00094846664558963	3163	7167	3775,9424,10089	KCNK1,KCNK6,KCNK7
REACT_163734	STAT6-mediated induction of chemokines	0.0859122613106339	-2.45442872082276	3	3	0.00094846664558963	3163	7167	29110,6778,340061	TBK1,STAT6,TMEM173
REACT_13653	FMO oxidizes nucleophiles	0.0859122613106339	-2.45442872082276	3	3	0.00094846664558963	3163	7167	2326,2327,2328	FMO1,FMO2,FMO3
REACT_13472	Breakdown of the nuclear lamina	0.0859122613106339	-2.45442872082276	3	3	0.00094846664558963	3163	7167	4001,839,4000	LMNB1,CASP6,LMNA
REACT_15514	Dopamine clearance from the synaptic cleft	0.0859122613106339	-2.45442872082276	3	3	0.00094846664558963	3163	7167	4128,1312,6531	MAOA,COMT,SLC6A3
REACT_115755	Signaling by ERBB2	0.0895780933533741	-2.41264448271869	159	79	0.0249762883338603	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,5578,5566,7409,5154,5136,6464,10193,5296,5290,109,8503,3815,5567,5159,113,64223,7311,2931,207,2249,107,5577,3710,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,27161,79109,23239,6714,2261,117145,5580,5781,112,2065,3320,1385,6199,5170,2264,2254,3164,27006,5295,5575,3845,5605,1956,7316,2248,57761,111,10000,26281,2886,8817,3708,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,PRKCA,PRKACA,VAV1,PDGFA,PDE1A,SHC1,RNF41,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,UBA52,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,MAPKAP1,PHLPP1,SRC,FGFR3,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,HSP90AA1,CREB1,RPS6KB2,PDPK1,FGFR4,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,UBC,FGF3,TRIB3,ADCY5,AKT3,FGF20,GRB7,FGF18,ITPR1,HRAS,CD28
REACT_13685	Neuronal System	0.0896408103003391	-2.41194459059518	293	141	0.0445779323427126	3163	7167	3779,84254,9254,2782,5578,2752,161,6196,3781,7881,6843,83795,1739,109,1312,1146,6512,5567,8514,81539,2788,3312,6531,3752,3757,8675,3785,3762,3765,170850,3775,114,59345,83988,3780,3767,1145,3739,10089,84694,27012,55584,89822,80331,9482,3777,10228,3756,2890,1142,3783,5864,112,56666,2771,5330,2567,6811,3768,6237,3786,8224,1135,2900,1137,160,3782,43,2054,6582,9196,5894,3754,6195,3763,112755,10021,3766,5566,2783,5331,6833,2899,3776,127833,815,10369,113,1139,27092,2036,107,8973,3746,610,26251,548645,2554,817,80852,3755,346562,4128,784,774,348980,2774,1141,2566,6538,88,2570,3749,24145,3737,2793,51764,10815,1385,818,57657,5170,5923,51305,3759,9568,777,773,3778,2902,2786,3784,6804,111,816,1103,3788,6571,3265,9424,8676	KCNMB1,CAMKK1,CACNA2D2,GNB1,PRKCA,GLUL,AP2A2,RPS6KA2,KCNN2,KCNAB1,VAMP1,KCNK16,DLG1,ADCY3,COMT,CHRNG,SLC1A7,PRKACB,KCNAB2,SLC38A1,GNG7,HSPA8,SLC6A3,KCND3,KCNH2,STX16,KCNQ2,KCNJ5,KCNJ9,KCNG3,KCNK1,ADCY8,GNB4,NCALD,KCNN1,KCNJ11,CHRNE,KCNA4,KCNK7,GJA10,KCNV1,CHRNA9,KCNK17,DNAJC5,STX8,KCNK3,STX6,KCNH1,GRIA1,CHRNB3,KCNN4,RAB3A,ADCY6,PANX2,GNAI2,PLCB2,GABRG3,STX5,KCNJ12,RRAS,KCNQ3,SYN3,CHRNA2,GRIK4,CHRNA4,AP2A1,KCNN3,ACHE,STX2,SLC22A2,KCNAB3,RAF1,KCNF1,RPS6KA1,KCNJ6,STX1B,HCN4,KCNJ10,PRKACA,GNB2,PLCB3,ABCC8,GRIK3,KCNK2,SYT2,CAMK2A,CACNG2,ADCY7,CHRNA7,CACNG4,EPB41L1,ADCY1,CHRNA6,KCNC1,HCN2,KCNG2,DNAJC25,GABRA1,CAMK2D,GRIP2,KCNG1,GNAT3,MAOA,CACNB3,CACNA1B,HCN1,GNAL,CHRNB2,GABRG2,SLC6A11,ACTN2,GABRR2,KCNC4,PANX1,KCNA2,GNGT2,GNG13,CPLX1,CREB1,CAMK2G,HCN3,PDPK1,RASGRF1,KCNK9,KCNJ2,GABBR2,CACNA1E,CACNA1A,KCNMA1,GRIN1,GNG4,KCNQ1,STX1A,ADCY5,CAMK2B,CHAT,KCNS2,SLC18A2,HRAS,KCNK6,STX11
REACT_11208	Golgi to ER Retrograde Transport	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	55738,22818,375,1314,8729,11316,9276	ARFGAP1,COPZ1,ARF1,COPA,GBF1,COPE,COPB2
REACT_11096	COPI Mediated Transport	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	55738,22818,375,1314,8729,11316,9276	ARFGAP1,COPZ1,ARF1,COPA,GBF1,COPE,COPB2
REACT_832	Dimerization of procaspase-8	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	356,8737,8743,7186,8772,355,8837	FASLG,RIPK1,TNFSF10,TRAF2,FADD,FAS,CFLAR
REACT_164011	Regulation by c-FLIP	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	356,8737,8743,7186,8772,355,8837	FASLG,RIPK1,TNFSF10,TRAF2,FADD,FAS,CFLAR
REACT_1503	Caspase-8 activation	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	356,8737,8743,7186,8772,355,8837	FASLG,RIPK1,TNFSF10,TRAF2,FADD,FAS,CFLAR
REACT_15312	Adenylate cyclase activating pathway	0.0921191673316721	-2.38467224302326	10	7	0.00221308883970914	3163	7167	109,112,114,111,2774,113,107	ADCY3,ADCY6,ADCY8,ADCY5,GNAL,ADCY7,ADCY1
REACT_121314	Heparan sulfate/heparin (HS-GAG) metabolism	0.099905933414255	-2.30352620155527	54	29	0.00916851090736642	3163	7167	126792,375790,8509,3339,9957,6385,26229,9672,2131,64711,63827,6382,3340,3423,9394,9951,6448,10855,1462,4669,9953,633,2817,3425,11285,27087,1464,9955,266722	B3GALT6,AGRN,NDST2,HSPG2,HS3ST1,SDC4,B3GAT3,SDC3,EXT1,HS3ST6,BCAN,SDC1,NDST1,IDS,HS6ST1,HS3ST4,SGSH,HPSE,VCAN,NAGLU,HS3ST3B1,BGN,GPC1,IDUA,B4GALT7,B3GAT1,CSPG4,HS3ST3A1,HS6ST3
REACT_75897	Tandem pore domain potassium channels	0.100228181586901	-2.3003058765134	12	8	0.00252924438823901	3163	7167	3776,89822,51305,3777,3775,9424,10089,83795	KCNK2,KCNK17,KCNK9,KCNK3,KCNK1,KCNK6,KCNK7,KCNK16
REACT_27307	Interleukin-6 signaling	0.100228181586901	-2.3003058765134	12	8	0.00252924438823901	3163	7167	3717,3570,867,6774,7297,3572,9021,5781	JAK2,IL6R,CBL,STAT3,TYK2,IL6ST,SOCS3,PTPN11
REACT_19333	G alpha (z) signalling events	0.104398440166371	-2.25954054458036	48	26	0.00822004426177679	3163	7167	5999,152,10287,2788,8601,107,2786,2782,5578,2783,548645,5583,26575,2781,2793,114,111,59345,5580,346562,112,109,51764,2771,113,150	RGS4,ADRA2C,RGS19,GNG7,RGS20,ADCY1,GNG4,GNB1,PRKCA,GNB2,DNAJC25,PRKCH,RGS17,GNAZ,GNGT2,ADCY8,ADCY5,GNB4,PRKCD,GNAT3,ADCY6,ADCY3,GNG13,GNAI2,ADCY7,ADRA2A
REACT_118744	Pre-NOTCH Expression and Processing	0.104398440166371	-2.25954054458036	48	26	0.00822004426177679	3163	7167	4851,57690,2648,8850,3955,489,27161,5045,4242,1871,2683,4853,5870,10402,6487,3725,595,6484,5986,7027,10046,6400,3516,9794,7029,27327	NOTCH1,TNRC6C,KAT2A,KAT2B,LFNG,ATP2A3,AGO2,FURIN,MFNG,E2F3,B4GALT1,NOTCH2,RAB6A,ST3GAL6,ST3GAL3,JUN,CCND1,ST3GAL4,RFNG,TFDP1,MAMLD1,SEL1L,RBPJ,MAML1,TFDP2,TNRC6A
REACT_120888	CS/DS degradation	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	3423,8372,1462,3373,633,63827,411,3425,1464	IDS,HYAL3,VCAN,HYAL1,BGN,BCAN,ARSB,IDUA,CSPG4
REACT_25282	Inhibition of adenylate cyclase pathway	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	114,111,2774,346562,107,112,109,2771,113	ADCY8,ADCY5,GNAL,GNAT3,ADCY1,ADCY6,ADCY3,GNAI2,ADCY7
REACT_13696	NF-kB is activated and signals survival	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	7189,7311,3654,8878,4792,4790,3551,4804,7316	TRAF6,UBA52,IRAK1,SQSTM1,NFKBIA,NFKB1,IKBKB,NGFR,UBC
REACT_163993	IRF3-mediated induction of type I IFN	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	29110,51428,5591,11277,3661,81030,340061,3428,7520	TBK1,DDX41,PRKDC,TREX1,IRF3,ZBP1,TMEM173,IFI16,XRCC5
REACT_115662	Downregulation of ERBB2:ERBB3 signaling	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	7311,207,10000,10193,9542,2064,3084,2065,7316	UBA52,AKT1,AKT3,RNF41,NRG2,ERBB2,NRG1,ERBB3,UBC
REACT_1619	Death Receptor  Signalling	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	6868,7186,7132,8743,8737,356,8772,8837,355	ADAM17,TRAF2,TNFRSF1A,TNFSF10,RIPK1,FASLG,FADD,CFLAR,FAS
REACT_1096	Processing of Intronless Pre-mRNAs	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	1478,22916,51585,29894,8106,79869,1477,10978,10914	CSTF2,NCBP2,PCF11,CPSF1,PABPN1,CPSF7,CSTF1,CLP1,PAPOLA
REACT_15333	Adenylate cyclase inhibitory pathway	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	114,111,2774,346562,107,112,109,2771,113	ADCY8,ADCY5,GNAL,GNAT3,ADCY1,ADCY6,ADCY3,GNAI2,ADCY7
REACT_1059	Extrinsic Pathway for Apoptosis	0.105910244178056	-2.24516329660513	14	9	0.00284539993676889	3163	7167	6868,7186,7132,8743,8737,356,8772,8837,355	ADAM17,TRAF2,TNFRSF1A,TNFSF10,RIPK1,FASLG,FADD,CFLAR,FAS
REACT_15482	tRNA Aminoacylation	0.108667714275023	-2.21946054576232	42	23	0.00727157761618716	3163	7167	833,79731,51520,10352,4677,57505,10667,7407,80222,6897,51067,54938,2058,5917,1615,55699,27068,55157,23438,10056,7965,9521,79587	CARS,NARS2,LARS,WARS2,NARS,AARS2,FARS2,VARS,TARS2,TARS,YARS2,SARS2,EPRS,RARS,DARS,IARS2,PPA2,DARS2,HARS2,FARSB,AIMP2,EEF1E1,CARS2
REACT_6788	MyD88:Mal cascade initiated on plasma membrane	0.108720786224286	-2.21897227752186	90	46	0.0145431552323743	3163	7167	59307,3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,1849,7311,5609,7867,51295,929,57162,246330,1846,2353,948,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	SIGIRR,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,CD14,PELI1,PELI3,DUSP4,FOS,CD36,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_8005	Toll Like Receptor TLR1:TLR2 Cascade	0.108720786224286	-2.21897227752186	90	46	0.0145431552323743	3163	7167	59307,3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,1849,7311,5609,7867,51295,929,57162,246330,1846,2353,948,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	SIGIRR,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,CD14,PELI1,PELI3,DUSP4,FOS,CD36,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_7980	Toll Like Receptor 2 (TLR2) Cascade	0.108720786224286	-2.21897227752186	90	46	0.0145431552323743	3163	7167	59307,3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,1849,7311,5609,7867,51295,929,57162,246330,1846,2353,948,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	SIGIRR,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,CD14,PELI1,PELI3,DUSP4,FOS,CD36,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_8006	Toll Like Receptor TLR6:TLR2 Cascade	0.108720786224286	-2.21897227752186	90	46	0.0145431552323743	3163	7167	59307,3146,7189,6195,387522,1660,4205,1432,9252,351,5606,3725,6196,3654,5518,4790,3551,5601,5600,1385,6885,4791,1386,1849,7311,5609,7867,51295,929,57162,246330,1846,2353,948,5605,983,7316,6283,5515,9261,8517,23118,4792,64127,5528,4208	SIGIRR,HMGB1,TRAF6,RPS6KA1,TMEM189-UBE2V1,DHX9,MEF2A,MAPK14,RPS6KA5,APP,MAP2K3,JUN,RPS6KA2,IRAK1,PPP2R1A,NFKB1,IKBKB,MAPK9,MAPK11,CREB1,MAP3K7,NFKB2,ATF2,DUSP7,UBA52,MAP2K7,MAPKAPK3,ECSIT,CD14,PELI1,PELI3,DUSP4,FOS,CD36,MAP2K2,CDK1,UBC,S100A12,PPP2CA,MAPKAPK2,IKBKG,TAB2,NFKBIA,NOD2,PPP2R5D,MEF2C
REACT_15530	PKA activation	0.109870547144119	-2.20845245035894	16	10	0.00316155548529877	3163	7167	114,111,5575,107,112,109,5577,5566,5567,113	ADCY8,ADCY5,PRKAR1B,ADCY1,ADCY6,ADCY3,PRKAR2B,PRKACA,PRKACB,ADCY7
REACT_20649	Cell-extracellular matrix interactions	0.109870547144119	-2.20845245035894	16	10	0.00316155548529877	3163	7167	2318,29780,54751,5829,7016,55679,3688,87,2316,6251	FLNC,PARVB,FBLIM1,PXN,TESK1,LIMS2,ITGB1,ACTN1,FLNA,RSU1
REACT_150149	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.109870547144119	-2.20845245035894	16	10	0.00316155548529877	3163	7167	127281,5743,873,5740,5730,6916,3248,5742,22949,9536	FAM213B,PTGS2,CBR1,PTGIS,PTGDS,TBXAS1,HPGD,PTGS1,PTGR1,PTGES
REACT_115720	PLCG1 events in ERBB2 signaling	0.112426566515183	-2.18545501255379	36	20	0.00632311097059753	3163	7167	5575,5137,107,2064,5577,5578,3710,5566,1956,5335,5136,111,114,5580,3708,112,109,1385,5567,113	PRKAR1B,PDE1C,ADCY1,ERBB2,PRKAR2B,PRKCA,ITPR3,PRKACA,EGFR,PLCG1,PDE1A,ADCY5,ADCY8,PRKCD,ITPR1,ADCY6,ADCY3,CREB1,PRKACB,ADCY7
REACT_23879	Platelet sensitization by LDL	0.112574310757918	-2.18414173532785	18	11	0.00347771103382864	3163	7167	5321,5515,5529,2268,5525,5518,5777,5781,1432,7804,5528	PLA2G4A,PPP2CA,PPP2R5E,FGR,PPP2R5A,PPP2R1A,PTPN6,PTPN11,MAPK14,LRP8,PPP2R5D
REACT_999	SHC-related events	0.112574310757918	-2.18414173532785	18	11	0.00347771103382864	3163	7167	3643,6464,53358,5894,3845,723961,5605,3265,983,3630,25759	INSR,SHC1,SHC3,RAF1,KRAS,INS-IGF2,MAP2K2,HRAS,CDK1,INS,SHC2
REACT_21387	Energy dependent regulation of mTOR by LKB1-AMPK	0.112574310757918	-2.18414173532785	18	11	0.00347771103382864	3163	7167	57521,5563,5564,51422,7249,5565,92335,5562,55437,6009,53632	RPTOR,PRKAA2,PRKAB1,PRKAG2,TSC2,PRKAB2,STRADA,PRKAA1,STRADB,RHEB,PRKAG3
REACT_150203	IRS-related events triggered by IGF1R	0.113090161389166	-2.17956989001383	86	44	0.0139108441353146	3163	7167	5563,5564,7249,2475,5565,92335,5894,5562,11344,29904,57521,2261,5296,117145,5781,5290,54106,1977,64223,2264,5170,2254,1975,2249,27006,5295,55437,3845,8471,5605,983,6009,2260,2248,53632,2246,1981,57761,51422,1978,26281,8817,6198,3265	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,STRADA,RAF1,PRKAA1,TWF2,EEF2K,RPTOR,FGFR3,PIK3R2,THEM4,PTPN11,PIK3CA,TLR9,EIF4E,MLST8,FGFR4,PDPK1,FGF9,EIF4B,FGF4,FGF22,PIK3R1,STRADB,KRAS,IRS4,MAP2K2,CDK1,RHEB,FGFR1,FGF3,PRKAG3,FGF1,EIF4G1,TRIB3,PRKAG2,EIF4EBP1,FGF20,FGF18,RPS6KB1,HRAS
REACT_12578	GAB1 signalosome	0.113788943135267	-2.17340992250882	103	52	0.0164400885235536	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,6714,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,5829,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,SRC,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,PXN,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_6867	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.114339908505229	-2.16857961334579	20	12	0.00379386658235852	3163	7167	64682,51433,8881,996,991,51343,10393,51434,8697,11065,29945,7324	ANAPC1,ANAPC5,CDC16,CDC27,CDC20,FZR1,ANAPC10,ANAPC7,CDC23,UBE2C,ANAPC4,UBE2E1
REACT_6904	Phosphorylation of the APC/C	0.114339908505229	-2.16857961334579	20	12	0.00379386658235852	3163	7167	64682,51433,8881,996,10393,51434,891,8697,11065,983,29945,7324	ANAPC1,ANAPC5,CDC16,CDC27,ANAPC10,ANAPC7,CCNB1,CDC23,UBE2C,CDK1,ANAPC4,UBE2E1
REACT_1319	Fatty Acyl-CoA Biosynthesis	0.114339908505229	-2.16857961334579	20	12	0.00379386658235852	3163	7167	51703,60481,2180,6785,79071,23305,2181,47,2194,64834,51144,6576	ACSL5,ELOVL5,ACSL1,ELOVL4,ELOVL6,ACSL6,ACSL3,ACLY,FASN,ELOVL1,HSD17B12,SLC25A1
REACT_120916	Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha	0.114339908505229	-2.16857961334579	20	12	0.00379386658235852	3163	7167	7323,7311,6923,112398,2034,3091,9978,8453,7322,6921,7316,54583	UBE2D3,UBA52,TCEB2,EGLN2,EPAS1,HIF1A,RBX1,CUL2,UBE2D2,TCEB1,UBC,EGLN1
REACT_120999	Signaling by FGFR1 mutants	0.115161332846534	-2.16142123943805	30	17	0.0053746443250079	3163	7167	613,9208,2254,8805,2249,5295,1523,2260,2246,5335,26281,399687,5290,6776,6774,7750,26127	BCR,LRRFIP1,FGF9,TRIM24,FGF4,PIK3R1,CUX1,FGFR1,FGF1,PLCG1,FGF20,MYO18A,PIK3CA,STAT5A,STAT3,ZMYM2,FGFR1OP2
REACT_11149	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.115392068338365	-2.15941965917353	22	13	0.0041100221308884	3163	7167	161,920,10053,653653,8905,160,8907,567,375,51606,130340,940,3105	AP2A2,CD4,AP1M2,LOC653653,AP1S2,AP2A1,AP1M1,B2M,ARF1,ATP6V1H,AP1S3,CD28,HLA-A
REACT_160205	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.115392068338365	-2.15941965917353	22	13	0.0041100221308884	3163	7167	4192,142678,7311,54567,182,28514,51107,5664,4853,3714,54492,7316,9148	MDK,MIB2,UBA52,DLL4,JAG1,DLL1,APH1A,PSEN2,NOTCH2,JAG2,NEURL1B,UBC,NEURL1
REACT_571	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.115697780043668	-2.15677383214318	28	16	0.00505848877647803	3163	7167	5441,6908,5440,84265,5451,7702,6618,6621,51728,661,55718,55290,5434,5437,11178,10302	POLR2L,TBP,POLR2K,POLR3GL,POU2F1,ZNF143,SNAPC2,SNAPC4,POLR3K,POLR3D,POLR3E,BRF2,POLR2E,POLR2H,LZTS1,SNAPC5
REACT_957	Pyrimidine metabolism	0.115893614972721	-2.15508262098469	24	14	0.00442617767941827	3163	7167	790,1890,1633,7378,1807,7371,1723,83549,1635,30833,51251,56953,7084,4907	CAD,TYMP,DCK,UPP1,DPYS,UCK2,DHODH,UCK1,DCTD,NT5C,NT5C3A,NT5M,TK2,NT5E
REACT_121369	Acyl chain remodelling of PE	0.115893614972721	-2.15508262098469	24	14	0.00442617767941827	3163	7167	283748,5321,8605,255189,254531,81579,154141,10162,50640,129642,8398,100137049,8399,123745	PLA2G4D,PLA2G4A,PLA2G4C,PLA2G4F,LPCAT4,PLA2G12A,MBOAT1,LPCAT3,PNPLA8,MBOAT2,PLA2G6,PLA2G4B,PLA2G10,PLA2G4E
REACT_12433	Nuclear Events (kinase and transcription factor activation)	0.115893614972721	-2.15508262098469	24	14	0.00442617767941827	3163	7167	9261,5515,6196,5518,6195,4205,5600,1846,1385,9252,1432,5528,1849,4208	MAPKAPK2,PPP2CA,RPS6KA2,PPP2R1A,RPS6KA1,MEF2A,MAPK11,DUSP4,CREB1,RPS6KA5,MAPK14,PPP2R5D,DUSP7,MEF2C
REACT_20558	Smooth Muscle Contraction	0.115893614972721	-2.15508262098469	24	14	0.00442617767941827	3163	7167	10580,5829,7170,7169,7094,800,4638,25802,7171,10174,3672,7168,7414,103910	SORBS1,PXN,TPM3,TPM2,TLN1,CALD1,MYLK,LMOD1,TPM4,SORBS3,ITGA1,TPM1,VCL,MYL12B
REACT_115606	O-linked glycosylation of mucins	0.115955426426731	-2.1545494166626	63	33	0.0104331331014859	3163	7167	140453,79695,4588,114805,27090,200958,6484,56913,4585,50614,146712,374378,2650,93010,374907,9245,64409,4583,51809,79623,10610,6487,4582,2590,442117,727897,6483,10071,117248,55568,394263,6482,10331	MUC17,GALNT12,MUC6,GALNT13,ST6GALNAC4,MUC20,ST3GAL4,C1GALT1,MUC4,GALNT9,B3GNTL1,GALNT18,GCNT1,B3GNT7,B3GNT8,GCNT3,WBSCR17,MUC2,GALNT7,GALNT14,ST6GALNAC2,ST3GAL3,MUC1,GALNT2,GALNTL6,MUC5B,ST3GAL2,MUC12,GALNT15,GALNT10,MUC21,ST3GAL1,B3GNT3
REACT_163710	WNT ligand biogenesis and trafficking	0.115965165695691	-2.15446542870037	26	15	0.00474233322794815	3163	7167	54361,50999,7483,7475,81029,80326,7472,7476,8724,7477,7481,89780,7484,55737,7478	WNT4,TMED5,WNT9A,WNT6,WNT5B,WNT10A,WNT2,WNT7A,SNX3,WNT7B,WNT11,WNT3A,WNT9B,VPS35,WNT8A
REACT_19277	Sema4D induced cell migration and growth-cone collapse	0.115965165695691	-2.15446542870037	26	15	0.00474233322794815	3163	7167	391,5880,10507,9826,727758,3984,389,2064,4627,23365,6093,4628,103910,388,5364	RHOG,RAC2,SEMA4D,ARHGEF11,ROCK1P1,LIMK1,RHOC,ERBB2,MYH9,ARHGEF12,ROCK1,MYH10,MYL12B,RHOB,PLXNB1
REACT_120829	Acyl chain remodelling of PC	0.115965165695691	-2.15446542870037	26	15	0.00474233322794815	3163	7167	283748,5321,8605,255189,254531,81579,10162,50640,79888,129642,151056,8398,100137049,8399,123745	PLA2G4D,PLA2G4A,PLA2G4C,PLA2G4F,LPCAT4,PLA2G12A,LPCAT3,PNPLA8,LPCAT1,MBOAT2,PLB1,PLA2G6,PLA2G4B,PLA2G10,PLA2G4E
REACT_21270	PI-3K cascade	0.118456291767215	-2.1332112322936	99	50	0.0158077774264938	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_75829	PIP3 activates AKT signaling	0.118456291767215	-2.1332112322936	99	50	0.0158077774264938	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_147723	PI3K/AKT Signaling in Cancer	0.118456291767215	-2.1332112322936	99	50	0.0158077774264938	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_116008	PI3K events in ERBB2 signaling	0.118456291767215	-2.1332112322936	99	50	0.0158077774264938	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_115961	PI3K events in ERBB4 signaling	0.118456291767215	-2.1332112322936	99	50	0.0158077774264938	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_467	mRNA Splicing - Major Pathway	0.122313255529162	-2.10116985680527	112	56	0.0177047107176731	3163	7167	3178,6627,5440,6431,10250,9939,10978,1660,4799,10949,6635,3187,220988,83443,10992,10914,6632,29894,6427,84844,10189,3184,3191,4904,3192,55749,1477,5438,5441,5725,6628,51639,10921,3185,3183,11100,51585,10907,8175,10421,6426,57794,5439,10262,10236,5434,8243,1478,22916,5437,9128,2521,6625,9785,79869,8106	HNRNPA1,SNRPA1,POLR2K,SRSF6,SRRM1,RBM8A,CLP1,DHX9,NFX1,HNRNPA0,SNRPE,HNRNPH1,HNRNPA3,SF3B5,SF3B2,PAPOLA,SNRPD1,CPSF1,SRSF2,PHF5A,ALYREF,HNRNPD,HNRNPL,YBX1,HNRNPU,CCAR1,CSTF1,POLR2I,POLR2L,PTBP1,SNRPB,SF3B14,RNPS1,HNRNPF,HNRNPC,HNRNPUL1,PCF11,TXNL4A,SF3A2,CD2BP2,SRSF1,SUGP1,POLR2J,SF3B4,HNRNPR,POLR2E,SMC1A,CSTF2,NCBP2,POLR2H,PRPF4,FUS,SNRNP70,DHX38,CPSF7,PABPN1
REACT_1735	mRNA Splicing	0.122313255529162	-2.10116985680527	112	56	0.0177047107176731	3163	7167	3178,6627,5440,6431,10250,9939,10978,1660,4799,10949,6635,3187,220988,83443,10992,10914,6632,29894,6427,84844,10189,3184,3191,4904,3192,55749,1477,5438,5441,5725,6628,51639,10921,3185,3183,11100,51585,10907,8175,10421,6426,57794,5439,10262,10236,5434,8243,1478,22916,5437,9128,2521,6625,9785,79869,8106	HNRNPA1,SNRPA1,POLR2K,SRSF6,SRRM1,RBM8A,CLP1,DHX9,NFX1,HNRNPA0,SNRPE,HNRNPH1,HNRNPA3,SF3B5,SF3B2,PAPOLA,SNRPD1,CPSF1,SRSF2,PHF5A,ALYREF,HNRNPD,HNRNPL,YBX1,HNRNPU,CCAR1,CSTF1,POLR2I,POLR2L,PTBP1,SNRPB,SF3B14,RNPS1,HNRNPF,HNRNPC,HNRNPUL1,PCF11,TXNL4A,SF3A2,CD2BP2,SRSF1,SUGP1,POLR2J,SF3B4,HNRNPR,POLR2E,SMC1A,CSTF2,NCBP2,POLR2H,PRPF4,FUS,SNRNP70,DHX38,CPSF7,PABPN1
REACT_19275	Sodium-coupled phosphate cotransporters	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	6569,142680,6574,6575	SLC34A1,SLC34A3,SLC20A1,SLC20A2
REACT_22423	Synthesis of GDP-mannose	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	29925,5372,5373,29926	GMPPB,PMM1,PMM2,GMPPA
REACT_160305	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	6500,4851,55294,9978	SKP1,NOTCH1,FBXW7,RBX1
REACT_2101	Cyclin B2 mediated events	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	993,994,995,983	CDC25A,CDC25B,CDC25C,CDK1
REACT_6772	S6K1 signalling	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	1981,6198,1975,29904	EIF4G1,RPS6KB1,EIF4B,EEF2K
REACT_1846	G2/M DNA replication checkpoint	0.122627083709891	-2.09860736870365	5	4	0.00126462219411951	3163	7167	7465,9088,891,983	WEE1,PKMYT1,CCNB1,CDK1
REACT_116125	Disease	0.125290589190918	-2.07711952611846	1088	498	0.157445463167879	3163	7167	57530,10015,5684,8805,3339,7249,5611,3949,9542,2782,8349,4869,5578,63827,3037,6497,6484,10053,6843,5290,8907,1836,5499,81929,55454,64223,7311,8905,1523,6924,3021,5577,3340,81034,5167,5335,51160,6827,4087,291,25805,904,114,5714,6208,728458,399687,4254,2932,5054,5437,527,6483,8337,92126,7029,128312,6188,3066,8086,9208,4836,5689,4594,8850,5440,9957,26229,2683,8970,7048,23521,129401,2280,6137,811,51564,4609,6170,5902,10898,3425,79902,29967,64087,7089,93010,2967,6154,58513,157506,2194,6229,8630,7469,7045,4548,5605,5685,1528,7520,5699,155382,2957,5439,119391,56937,3091,10254,1025,1462,160,3708,6223,9688,121214,723961,940,10331,27304,3292,2054,685,1839,5894,10402,5566,351,10560,51293,80308,6464,9110,51377,10213,388531,127833,3815,79178,113,9550,25920,6881,902,2931,8370,5441,53354,9525,6169,107,6232,820,867,3710,2260,3630,6191,5515,2534,29082,122706,7514,9759,51363,10046,5590,6176,2779,6500,3084,64220,9953,8566,8703,166012,6011,7804,9612,57690,8534,6908,3843,6385,567,113189,6714,9491,3105,1504,1471,117145,5781,2065,1385,10253,1464,3945,5170,55163,4851,5096,2254,7050,6470,5829,2648,8509,5295,5045,6132,5710,54492,166785,7316,9962,8787,57761,6573,6448,9146,6161,5091,6804,10000,7027,1211,6776,3159,10197,411,8676,11285,8945,1234,142678,126961,349565,375790,942,4240,56922,50848,8358,2131,64711,1026,10013,92737,6382,30011,525,8692,79586,161,2331,60496,23225,5136,6141,5696,28514,653653,5145,919,5296,9061,5701,5664,60490,3373,109,633,7750,5567,26127,5159,4689,8034,51107,9978,9963,6160,85236,4736,8675,93100,983,5549,9394,2934,10855,1208,4669,5959,7251,440387,27183,8992,8650,8106,27327,266722,9958,10090,7323,50515,9482,4092,90423,3978,29924,10861,83933,22856,23239,8702,9249,10228,10135,11097,8178,2961,2356,3000,6205,6548,112,9794,51606,2978,9114,5686,8788,6811,613,2264,337876,23370,5438,64802,7090,27006,8841,79643,9672,3845,6921,55048,1956,2248,5704,25873,3423,2652,1104,26508,23645,1840,176,5434,6907,4843,79646,27087,65220,333932,4166,920,54567,6181,2475,5721,6235,6513,79885,4647,5137,285596,336,2064,5949,112755,821,151056,1794,4688,6135,5154,7409,533,9951,182,5687,2968,5518,23057,55746,55229,8503,55294,3017,2817,326625,1727,6159,6923,142,207,55312,2249,6142,8021,6487,6203,3921,27010,9148,2246,4088,10718,8372,10312,5933,5709,388585,7088,128866,5158,6146,3020,8338,6482,4089,56288,9955,6202,9150,55191,55576,8874,27161,6017,79109,5948,7046,3714,375,9734,2261,6234,883,3038,3726,5580,653604,3320,960,130340,6774,3837,6667,6199,3161,7091,126792,3280,6868,5692,10243,79718,3164,5575,57016,5905,8038,4221,51652,9227,3304,6189,7175,111,26281,81693,6874,8817,127124,55790,408,22916,113878,9469,3516,6206,528,91782,3265	CGN,PDCD6IP,PSMA3,TRIM24,HSPG2,TSC2,DNAJC3,LDLR,NRG2,GNB1,HIST2H2BE,NPM1,PRKCA,BCAN,HAS2,SKI,ST3GAL4,AP1M2,VAMP1,PIK3CA,AP1M1,SLC26A2,PPP1CA,SEH1L,CSGALNACT2,MLST8,UBA52,AP1S2,CUX1,TCEB3,H3F3B,PRKAR2B,NDST1,SLC25A32,ENPP1,PLCG1,VPS28,SUPT4H1,SMAD2,SLC25A4,BAMBI,CCNT1,ADCY8,PSMD8,RPS14,OPN1MW2,MYO18A,KITLG,GSK3B,SERPINE1,POLR2H,ATP6V0C,ST3GAL2,HIST2H2AA3,DSEL,TFDP2,HIST3H2BB,RPS3,HDAC2,AAAS,LRRFIP1,NMT1,PSMB1,MUT,KAT2B,POLR2K,HS3ST1,B3GAT3,B4GALT1,HIST1H2BJ,TGFBR2,RPL13A,NUP35,FKBP1A,RPL13,CALR,HDAC7,MYC,RPL39,RANBP1,CPSF4,IDUA,NUP85,LRP12,MCCC2,TLE2,B3GNT7,GTF2H3,RPL26,EPS15L1,RDH10,FASN,RPS24,HSD17B6,NELFA,TGFBI,MTR,MAP2K2,PSMA4,CYB5A,XRCC5,PSMB10,VPS37D,GTF2A1,POLR2J,GSTO2,PMEPA1,HIF1A,STAM2,CDK9,VCAN,AP2A1,ITPR1,RPS19,NUP93,SDR9C7,INS-IGF2,CD28,B3GNT3,MOCS3,HSD17B1,STX2,BTC,HBEGF,RAF1,ST3GAL6,PRKACA,APP,SLC19A2,CD320,FLAD1,SHC1,MTMR4,UCHL5,PSMD14,RGS9BP,SYT2,KIT,THTPA,ADCY7,ATP6V1G1,NELFB,TAF10,CCNH,GSK3A,HIST2H4A,POLR2L,PANK1,VPS4B,RPL38,ADCY1,RPS27,CAMP,CBL,ITPR3,FGFR1,INS,RPS4X,PPP2CA,FYN,CHMP4A,PSMB11,XPO1,HDAC4,CHST15,MAMLD1,PRKCZ,RPLP1,GNAT1,SKP1,NRG1,STRA6,HS3ST3B1,PDXK,B4GALT3,CHST13,GRK1,LRP8,NCOR2,TNRC6C,CHST1,TBP,IPO5,SDC4,B2M,CHST14,SRC,PSMF1,HLA-A,CTRB1,CST3,THEM4,PTPN11,ERBB3,CREB1,SPRY2,CSPG4,LDHB,PDPK1,PNPO,NOTCH1,PCCB,FGF9,TGIF1,SHMT1,PXN,KAT2A,NDST2,PIK3R1,FURIN,RPL8,PSMD4,NEURL1B,MMAA,UBC,SLC23A2,RGS9,TRIB3,SLC19A1,SGSH,HGS,RPL32,PC,STX1A,AKT3,TFDP1,CLTA,STAT5A,HMGA1,PSME3,ARSB,STX11,B4GALT7,BTRC,CCR5,MIB2,HIST2H3C,NMNAT3,AGRN,CD86,MFGE8,MCCC1,F11R,HIST1H3B,EXT1,HS3ST6,CDKN1A,HDAC6,DNER,SDC1,SH3KBP1,ATP6V1B1,HYAL2,CHPF,AP2A2,FMOD,AASDHPPT,NUP210,PDE1A,RPL18,PSMB8,DLL1,LOC653653,PDE6A,CD247,PIK3R2,PAPSS1,PSMC2,PSEN2,PPCDC,HYAL1,ADCY3,BGN,ZMYM2,PRKACB,FGFR1OP2,PDGFRB,NCF4,SLC25A16,APH1A,RBX1,SLC23A1,RPL31,HIST1H2BK,RPL10A,STX16,NAPRT1,CDK1,PRELP,HS6ST1,GSN,HPSE,CLPS,NAGLU,RDH5,TSG101,CTRB2,VPS4A,ATP6V0E1,NUMB,PABPN1,TNRC6A,HS6ST3,USP15,UST,UBE2D3,CHST11,STX8,SMAD7,ATP6V1E2,LIG1,EPN1,SLC26A1,HDAC10,CHSY1,PHLPP1,B4GALT4,DHRS3,STX6,NAMPT,NUPL2,ELL,GTF2E2,FPGS,GUCY2D,RPS11,SLC9A1,ADCY6,MAML1,ATP6V1H,GUCA1A,ATP6V0D1,PSMA5,DLK1,STX5,BCR,FGFR4,CHSY3,ARHGEF18,POLR2I,NMNAT1,TLE3,FGF22,HDAC3,CHMP6,SDC3,KRAS,TCEB1,VPS37C,EGFR,FGF3,PSMC4,RPL36,IDS,OPN1MW,RCC1,HEYL,PPP1R15A,DTX1,ACAN,POLR2E,TBL1X,NOS2,PANK3,B3GAT1,NADK,HIST2H3A,CHST6,CD4,DLL4,RPLP2,MTOR,PSME2,RPS29,SLC2A1,HDAC11,MYO7A,PDE1C,FAM153A,APOA2,ERBB2,RBP3,STX1B,CANX,PLB1,DOCK2,NCF2,RPL11,PDGFA,VAV1,ATP6V0B,HS3ST4,JAG1,PSMA6,GTF2H4,PPP2R1A,NMNAT2,NUP133,PANK4,PIK3R3,FBXW7,HIST1H2BD,GPC1,MMAB,CYB5R3,RPL29,TCEB2,PARP1,AKT1,RFK,FGF4,RPL18A,NUP214,ST3GAL3,RPS9,RPSA,TPK1,NEURL1,FGF1,SMAD3,NRG3,HYAL3,TCIRG1,RBL1,PSMD3,HES5,TLE1,CHMP4B,PDE6B,RPL22,H3F3A,HIST2H2AC,ST3GAL1,SMAD4,PARD3,HS3ST3A1,RPS8,CTDP1,NADSYN1,STAB2,ARHGEF7,AGO2,RLBP1,MAPKAP1,RBP2,TGFBR1,JAG2,ARF1,HDAC9,FGFR3,RPS28,CCBL1,HAS3,JUNB,PRKCD,HIST2H3D,HSP90AA1,CD44,AP1S3,STAT3,KPNB1,SP1,RPS6KB2,HMMR,TLE4,B3GALT6,HES1,ADAM17,PSMB4,GPHN,TBL1XR1,NR4A1,PRKAR1B,AKR1B10,RANGAP1,ADAM12,MEN1,CHMP3,LRAT,HSPA1B,RPS3A,TPR,ADCY5,FGF20,AMN,TAF4,FGF18,ATP6V1G3,CSGALNACT1,ARRB1,NCBP2,DTX2,CHST3,RBPJ,RPS12,ATP6V1C1,CHMP7,HRAS
REACT_147727	Constitutive PI3K/AKT Signaling in Cancer	0.133891427577811	-2.01072604941129	87	44	0.0139108441353146	3163	7167	685,1839,7249,942,2475,79109,2064,9542,1026,7409,5154,2261,5296,5290,5781,8503,2065,1385,3815,5159,64223,6199,5170,2264,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,2534,10718,10000,26281,8817,4254,2932,3084,940	BTC,HBEGF,TSC2,CD86,MTOR,MAPKAP1,ERBB2,NRG2,CDKN1A,VAV1,PDGFA,FGFR3,PIK3R2,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,PDPK1,FGFR4,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28
REACT_118823	Cytosolic sensors of pathogen-associated DNA	0.135443007719108	-1.99920433438148	68	35	0.0110654441985457	3163	7167	9208,3146,5440,1660,8737,3661,51728,351,661,1499,4790,3551,4791,81030,7311,29110,5441,51428,5591,84265,11277,7316,6283,7520,8517,6778,4792,55718,5434,3665,5437,11178,3428,340061,81844	LRRFIP1,HMGB1,POLR2K,DHX9,RIPK1,IRF3,POLR3K,APP,POLR3D,CTNNB1,NFKB1,IKBKB,NFKB2,ZBP1,UBA52,TBK1,POLR2L,DDX41,PRKDC,POLR3GL,TREX1,UBC,S100A12,XRCC5,IKBKG,STAT6,NFKBIA,POLR3E,POLR2E,IRF7,POLR2H,LZTS1,IFI16,TMEM173,TRIM56
REACT_12464	PI3K/AKT activation	0.135467291064924	-1.99902506215749	102	51	0.0161239329750237	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,7409,5154,2261,5296,117145,5290,5781,8503,2065,1385,3815,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,4914,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,VAV1,PDGFA,FGFR3,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,ERBB3,CREB1,KIT,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,NTRK1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_118638	Downstream Signaling Events Of B Cell Receptor (BCR)	0.136582112062417	-1.99082929164712	171	83	0.0262409105279798	3163	7167	23291,685,1839,5684,7249,942,2475,5721,2064,9542,1026,7409,5154,5696,5687,4790,3551,5296,5701,5290,10213,8503,3815,5159,64223,7311,2931,207,2249,2260,2246,8517,2534,10718,122706,5714,5709,4254,2932,6500,3084,27327,5689,57690,4794,27161,79109,23239,9491,2261,117145,5781,2065,1385,6885,646626,5686,6199,5170,2264,2254,5692,3164,27006,5295,10892,3845,5710,5685,1956,7316,2248,5704,5699,57761,10000,26281,4792,8817,10197,3265,940,8945	FBXW11,BTC,HBEGF,PSMA3,TSC2,CD86,MTOR,PSME2,ERBB2,NRG2,CDKN1A,VAV1,PDGFA,PSMB8,PSMA6,NFKB1,IKBKB,PIK3R2,PSMC2,PIK3CA,PSMD14,PIK3R3,KIT,PDGFRB,MLST8,UBA52,GSK3A,AKT1,FGF4,FGFR1,FGF1,IKBKG,FYN,NRG3,PSMB11,PSMD8,PSMD3,KITLG,GSK3B,SKP1,NRG1,TNRC6A,PSMB1,TNRC6C,NFKBIE,AGO2,MAPKAP1,PHLPP1,PSMF1,FGFR3,THEM4,PTPN11,ERBB3,CREB1,MAP3K7,LOC646626,PSMA5,RPS6KB2,PDPK1,FGFR4,FGF9,PSMB4,NR4A1,FGF22,PIK3R1,MALT1,KRAS,PSMD4,PSMA4,EGFR,UBC,FGF3,PSMC4,PSMB10,TRIB3,AKT3,FGF20,NFKBIA,FGF18,PSME3,HRAS,CD28,BTRC
REACT_121398	Signaling by FGFR mutants	0.136636137438877	-1.99043381749953	45	24	0.00758773316471704	3163	7167	613,2264,9208,2254,8805,2249,27006,5295,1523,3845,2260,2248,2246,5335,2261,26281,399687,8817,5290,6776,7750,6774,3265,26127	BCR,FGFR4,LRRFIP1,FGF9,TRIM24,FGF4,FGF22,PIK3R1,CUX1,KRAS,FGFR1,FGF3,FGF1,PLCG1,FGFR3,FGF20,MYO18A,FGF18,PIK3CA,STAT5A,ZMYM2,STAT3,HRAS,FGFR1OP2
REACT_160315	Regulation of PLK1 Activity at G2/M Transition	0.139570760100246	-1.96918356546189	83	42	0.0132785330382548	3163	7167	22995,23291,1781,22919,5116,80321,4659,10383,891,7531,5566,22897,1069,4218,5518,80184,10733,4751,3320,80254,7277,7311,1454,55755,5577,22994,983,7316,1778,11190,22981,4957,10806,8481,6500,4660,55722,8636,55125,54820,1453,8945	CEP152,FBXW11,DYNC1I2,MAPRE1,PCNT,CEP70,PPP1R12A,TUBB4B,CCNB1,YWHAE,PRKACA,CEP164,CETN2,RAB8A,PPP2R1A,CEP290,PLK4,NEK2,HSP90AA1,CEP63,TUBA4A,UBA52,CSNK1E,CDK5RAP2,PRKAR2B,AZI1,CDK1,UBC,DYNC1H1,CEP250,NINL,ODF2,SDCCAG8,OFD1,SKP1,PPP1R12B,CEP72,SSNA1,CEP192,NDE1,CSNK1D,BTRC
REACT_15364	Loss of Nlp from mitotic centrosomes	0.141088897828376	-1.95836510622133	64	33	0.0104331331014859	3163	7167	22995,1781,22919,5116,80321,10383,7531,5566,22897,1069,5518,80184,10733,4751,3320,80254,7277,1454,55755,5577,22994,983,1778,11190,22981,10806,4957,8481,55722,8636,55125,54820,1453	CEP152,DYNC1I2,MAPRE1,PCNT,CEP70,TUBB4B,YWHAE,PRKACA,CEP164,CETN2,PPP2R1A,CEP290,PLK4,NEK2,HSP90AA1,CEP63,TUBA4A,CSNK1E,CDK5RAP2,PRKAR2B,AZI1,CDK1,DYNC1H1,CEP250,NINL,SDCCAG8,ODF2,OFD1,CEP72,SSNA1,CEP192,NDE1,CSNK1D
REACT_15451	Loss of proteins required for interphase microtubule organization from the centrosome	0.141088897828376	-1.95836510622133	64	33	0.0104331331014859	3163	7167	22995,1781,22919,5116,80321,10383,7531,5566,22897,1069,5518,80184,10733,4751,3320,80254,7277,1454,55755,5577,22994,983,1778,11190,22981,10806,4957,8481,55722,8636,55125,54820,1453	CEP152,DYNC1I2,MAPRE1,PCNT,CEP70,TUBB4B,YWHAE,PRKACA,CEP164,CETN2,PPP2R1A,CEP290,PLK4,NEK2,HSP90AA1,CEP63,TUBA4A,CSNK1E,CDK5RAP2,PRKAR2B,AZI1,CDK1,DYNC1H1,CEP250,NINL,SDCCAG8,ODF2,OFD1,CEP72,SSNA1,CEP192,NDE1,CSNK1D
REACT_216	DNA Repair	0.141257330943969	-1.95717200981409	113	56	0.0177047107176731	3163	7167	2176,4913,5440,56949,3978,2072,9656,3980,5424,8930,6118,5111,29089,2968,91442,27033,7507,5887,545,7398,57804,51455,2067,2967,1643,5438,7311,5983,5441,902,5591,5893,672,4350,2189,2178,2175,2188,4255,7316,7415,7520,2187,221120,5439,5426,7158,80233,10111,5434,472,5437,5981,4595,5425,1642	FANCC,NTHL1,POLR2K,XAB2,LIG1,ERCC4,MDC1,LIG3,POLD1,MBD4,RPA2,PCNA,UBE2T,GTF2H4,C19orf40,ZBTB32,XPA,RAD23B,ATR,USP1,POLD4,REV1,ERCC1,GTF2H3,DDB2,POLR2I,UBA52,RFC3,POLR2L,CCNH,PRKDC,RAD52,BRCA1,MPG,FANCG,FANCE,FANCA,FANCF,MGMT,UBC,VCP,XRCC5,FANCB,ALKBH3,POLR2J,POLE,TP53BP1,C17orf70,RAD50,POLR2E,ATM,POLR2H,RFC1,MUTYH,POLD2,DDB1
REACT_25149	Ion transport by P-type ATPases	0.141500175199683	-1.95545432373931	41	22	0.00695542206765729	3163	7167	538,492,10079,489,480,491,53828,495,481,23250,148229,57198,51761,374868,23120,476,486,5205,477,496,493,478	ATP7A,ATP2B3,ATP9A,ATP2A3,ATP1A4,ATP2B2,FXYD4,ATP4A,ATP1B1,ATP11A,ATP8B3,ATP8B2,ATP8A2,ATP9B,ATP10B,ATP1A1,FXYD2,ATP8B1,ATP1A2,ATP4B,ATP2B4,ATP1A3
REACT_25330	Activation of GABAB receptors	0.141500175199683	-1.95545432373931	41	22	0.00695542206765729	3163	7167	3768,3759,9568,2788,2774,3763,107,2786,2782,3766,2783,548645,3762,3765,2793,111,114,346562,112,109,2771,113	KCNJ12,KCNJ2,GABBR2,GNG7,GNAL,KCNJ6,ADCY1,GNG4,GNB1,KCNJ10,GNB2,DNAJC25,KCNJ5,KCNJ9,GNGT2,ADCY5,ADCY8,GNAT3,ADCY6,ADCY3,GNAI2,ADCY7
REACT_25031	GABA B receptor activation	0.141500175199683	-1.95545432373931	41	22	0.00695542206765729	3163	7167	3768,3759,9568,2788,2774,3763,107,2786,2782,3766,2783,548645,3762,3765,2793,111,114,346562,112,109,2771,113	KCNJ12,KCNJ2,GABBR2,GNG7,GNAL,KCNJ6,ADCY1,GNG4,GNB1,KCNJ10,GNB2,DNAJC25,KCNJ5,KCNJ9,GNGT2,ADCY5,ADCY8,GNAT3,ADCY6,ADCY3,GNAI2,ADCY7
REACT_9508	FGFR3b ligand binding and activation	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	2246,2254,2261,26281,8817	FGF1,FGF9,FGFR3,FGF20,FGF18
REACT_150268	Anchoring fibril formation	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	1294,3909,3918,649,3914	COL7A1,LAMA3,LAMC2,BMP1,LAMB3
REACT_22329	NrCAM interactions	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	286,6900,4897,8828,1739	ANK1,CNTN2,NRCAM,NRP2,DLG1
REACT_13673	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	3175,4851,3280,390874,3516	ONECUT1,NOTCH1,HES1,ONECUT3,RBPJ
REACT_22312	Neurofascin interactions	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	8506,23114,286,6386,4897	CNTNAP1,NFASC,ANK1,SDCBP,NRCAM
REACT_12524	CREB phosphorylation	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	9261,6196,1385,9252,6195	MAPKAPK2,RPS6KA2,CREB1,RPS6KA5,RPS6KA1
REACT_160083	The retinoid cycle in cones (daylight vision)	0.141772813820145	-1.95352940526692	7	5	0.00158077774264938	3163	7167	5949,2652,9249,728458,6017	RBP3,OPN1MW,DHRS3,OPN1MW2,RLBP1
REACT_899	S Phase	0.146088587120646	-1.92354208017858	124	61	0.0192854884603225	3163	7167	9134,5689,114799,4149,5684,5721,81620,3978,1026,5424,9491,898,4173,6118,595,7465,5687,5111,5696,4609,4174,5701,51343,10213,23047,1163,994,57804,5686,9837,993,4999,7311,5983,5692,10274,5558,902,1019,990,4171,5710,5685,84296,7316,5704,5699,122706,5426,51659,5709,5714,113130,84515,8243,6500,5981,10197,5425,4172,5885	CCNE2,PSMB1,ESCO1,MAX,PSMA3,PSME2,CDT1,LIG1,CDKN1A,POLD1,PSMF1,CCNE1,MCM4,RPA2,CCND1,WEE1,PSMA6,PCNA,PSMB8,MYC,MCM5,PSMC2,FZR1,PSMD14,PDS5B,CKS1B,CDC25B,POLD4,PSMA5,GINS1,CDC25A,ORC2,UBA52,RFC3,PSMB4,STAG1,PRIM2,CCNH,CDK4,CDC6,MCM2,PSMD4,PSMA4,GINS4,UBC,PSMC4,PSMB10,PSMB11,POLE,GINS2,PSMD3,PSMD8,CDCA5,MCM8,SMC1A,SKP1,RFC1,PSME3,POLD2,MCM3,RAD21
REACT_278	Platelet Aggregation (Plug Formation)	0.146372185518756	-1.92160268513123	37	20	0.00632311097059753	3163	7167	5170,152,2147,2335,207,7094,7066,11069,2812,2815,5747,4352,9564,6714,5770,6464,7450,10411,6850,150	PDPK1,ADRA2C,F2,FN1,AKT1,TLN1,THPO,RAPGEF4,GP1BB,GP9,PTK2,MPL,BCAR1,SRC,PTPN1,SHC1,VWF,RAPGEF3,SYK,ADRA2A
REACT_20593	Post NMDA receptor activation events	0.146372185518756	-1.92160268513123	37	20	0.00632311097059753	3163	7167	5170,5923,6237,84254,6195,5894,2902,107,88,5566,817,6196,816,114,109,1385,3265,5567,815,818	PDPK1,RASGRF1,RRAS,CAMKK1,RPS6KA1,RAF1,GRIN1,ADCY1,ACTN2,PRKACA,CAMK2D,RPS6KA2,CAMK2B,ADCY8,ADCY3,CREB1,HRAS,PRKACB,CAMK2A,CAMK2G
REACT_12079	PLC-gamma1 signalling	0.148784404681899	-1.90525696932111	35	19	0.00600695542206766	3163	7167	4914,5575,5137,107,5577,5578,3710,5566,5335,5136,111,114,5580,3708,112,109,1385,5567,113	NTRK1,PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,PLCG1,PDE1A,ADCY5,ADCY8,PRKCD,ITPR1,ADCY6,ADCY3,CREB1,PRKACB,ADCY7
REACT_281	RNA Polymerase III Transcription Initiation	0.148784404681899	-1.90525696932111	35	19	0.00600695542206766	3163	7167	2976,5441,9328,6908,5440,84265,5451,7702,6618,6621,51728,661,55718,55290,5434,5437,2972,11178,10302	GTF3C2,POLR2L,GTF3C5,TBP,POLR2K,POLR3GL,POU2F1,ZNF143,SNAPC2,SNAPC4,POLR3K,POLR3D,POLR3E,BRF2,POLR2E,POLR2H,BRF1,LZTS1,SNAPC5
REACT_12478	EGFR interacts with phospholipase C-gamma	0.148784404681899	-1.90525696932111	35	19	0.00600695542206766	3163	7167	5575,5137,107,5577,5578,3710,5566,1956,5335,5136,111,114,5580,3708,112,109,1385,5567,113	PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,EGFR,PLCG1,PDE1A,ADCY5,ADCY8,PRKCD,ITPR1,ADCY6,ADCY3,CREB1,PRKACB,ADCY7
REACT_13698	Regulation of beta-cell development	0.151160435499308	-1.88941351945639	33	18	0.00569079987353778	3163	7167	4851,3280,207,5313,3174,2494,3630,3175,3170,3651,2645,10000,389692,3642,3516,390874,723961,3172	NOTCH1,HES1,AKT1,PKLR,HNF4G,NR5A2,INS,ONECUT1,FOXA2,PDX1,GCK,AKT3,MAFA,INSM1,RBPJ,ONECUT3,INS-IGF2,HNF4A
REACT_111064	DAG and IP3 signaling	0.151160435499308	-1.88941351945639	33	18	0.00569079987353778	3163	7167	5575,5137,107,5577,5578,3710,5566,5335,5136,111,114,5580,3708,112,109,1385,5567,113	PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,PLCG1,PDE1A,ADCY5,ADCY8,PRKCD,ITPR1,ADCY6,ADCY3,CREB1,PRKACB,ADCY7
REACT_13620	p75NTR regulates axonogenesis	0.152582623400505	-1.8800490368612	9	6	0.00189693329117926	3163	7167	57142,4099,4804,9138,396,84894	RTN4,MAG,NGFR,ARHGEF1,ARHGDIA,LINGO1
REACT_18365	Lysosphingolipid and LPA receptors	0.152582623400505	-1.8800490368612	9	6	0.00189693329117926	3163	7167	8698,9170,53637,57121,23566,1903	S1PR4,LPAR2,S1PR5,LPAR5,LPAR3,S1PR3
REACT_655	Pyrimidine salvage reactions	0.152582623400505	-1.8800490368612	9	6	0.00189693329117926	3163	7167	83549,1890,1633,7378,7084,7371	UCK1,TYMP,DCK,UPP1,TK2,UCK2
REACT_75896	Ca2+ activated K+ channels	0.152582623400505	-1.8800490368612	9	6	0.00189693329117926	3163	7167	3779,3782,3780,3781,3783,3778	KCNMB1,KCNN3,KCNN1,KCNN2,KCNN4,KCNMA1
REACT_21402	CDO in myogenesis	0.153479592905143	-1.87418766603625	31	17	0.0053746443250079	3163	7167	1002,4656,1495,6929,4205,4209,50937,1432,25,1013,9043,1499,4654,5600,1000,6300,4208	CDH4,MYOG,CTNNA1,TCF3,MEF2A,MEF2D,CDON,MAPK14,ABL1,CDH15,SPAG9,CTNNB1,MYOD1,MAPK11,CDH2,MAPK12,MEF2C
REACT_932	DNA strand elongation	0.153479592905143	-1.87418766603625	31	17	0.0053746443250079	3163	7167	9837,5983,5558,3978,4171,5424,84296,6118,4173,5111,51659,4174,84515,5981,57804,4172,5425	GINS1,RFC3,PRIM2,LIG1,MCM2,POLD1,GINS4,RPA2,MCM4,PCNA,GINS2,MCM5,MCM8,RFC1,POLD4,MCM3,POLD2
REACT_21303	Myogenesis	0.153479592905143	-1.87418766603625	31	17	0.0053746443250079	3163	7167	1002,4656,1495,6929,4205,4209,50937,1432,25,1013,9043,1499,4654,5600,1000,6300,4208	CDH4,MYOG,CTNNA1,TCF3,MEF2A,MEF2D,CDON,MAPK14,ABL1,CDH15,SPAG9,CTNNB1,MYOD1,MAPK11,CDH2,MAPK12,MEF2C
REACT_120734	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.153479592905143	-1.87418766603625	31	17	0.0053746443250079	3163	7167	7050,7311,4092,4221,7316,4088,4087,5933,904,4609,1025,3726,7027,5054,7029,4089,6667	TGIF1,UBA52,SMAD7,MEN1,UBC,SMAD3,SMAD2,RBL1,CCNT1,MYC,CDK9,JUNB,TFDP1,SERPINE1,TFDP2,SMAD4,SP1
REACT_27258	Endosomal Sorting Complex Required For Transport (ESCRT)	0.155715129143402	-1.85972703631167	29	16	0.00505848877647803	3163	7167	7311,79643,9525,51652,55048,51028,7316,51160,29082,155382,9146,10254,7251,128866,27183,91782	UBA52,CHMP6,VPS4B,CHMP3,VPS37C,VPS36,UBC,VPS28,CHMP4A,VPS37D,HGS,STAM2,TSG101,CHMP4B,VPS4A,CHMP7
REACT_18277	PERK regulated gene expression	0.155715129143402	-1.85972703631167	29	16	0.00505848877647803	3163	7167	468,3484,3309,9451,467,5073,9709,167227,440,4800,56915,3576,8570,22926,54512,1649	ATF4,IGFBP1,HSPA5,EIF2AK3,ATF3,PARN,HERPUD1,DCP2,ASNS,NFYA,EXOSC5,IL8,KHSRP,ATF6,EXOSC4,DDIT3
REACT_6835	The role of Nef in HIV-1 replication and disease pathogenesis	0.155715129143402	-1.85972703631167	29	16	0.00505848877647803	3163	7167	920,8905,567,375,1794,3105,161,10053,2534,653653,160,919,8907,130340,51606,940	CD4,AP1S2,B2M,ARF1,DOCK2,HLA-A,AP2A2,AP1M2,FYN,LOC653653,AP2A1,CD247,AP1M1,AP1S3,ATP6V1H,CD28
REACT_150180	Assembly of collagen fibrils and other multimeric structures	0.156466411333577	-1.85491391610357	54	28	0.00885235535883655	3163	7167	4318,1292,1284,1277,1508,3655,1296,1295,977,80781,1294,5339,84695,1293,3914,667,3909,1520,1306,1289,1280,1291,1515,649,3691,4016,3918,4015	MMP9,COL6A2,COL4A2,COL1A1,CTSB,ITGA6,COL8A2,COL8A1,CD151,COL18A1,COL7A1,PLEC,LOXL3,COL6A3,LAMB3,DST,LAMA3,CTSS,COL15A1,COL5A1,COL2A1,COL6A1,CTSV,BMP1,ITGB4,LOXL1,LAMC2,LOX
REACT_120727	Downregulation of TGF-beta receptor signaling	0.157832129721192	-1.84622328089569	27	15	0.00474233322794815	3163	7167	4088,7311,7514,4087,56937,25805,9110,51377,23645,4092,7046,5499,7048,7316,9958	SMAD3,UBA52,XPO1,SMAD2,PMEPA1,BAMBI,MTMR4,UCHL5,PPP1R15A,SMAD7,TGFBR1,PPP1CA,TGFBR2,UBC,USP15
REACT_19140	ADP signalling through P2Y purinoceptor 1	0.157832129721192	-1.84622328089569	27	15	0.00474233322794815	3163	7167	5321,2769,2793,59345,2788,2786,2782,51764,5028,1432,6714,2783,2767,548645,9630	PLA2G4A,GNA15,GNGT2,GNB4,GNG7,GNG4,GNB1,GNG13,P2RY1,MAPK14,SRC,GNB2,GNA11,DNAJC25,GNA14
REACT_172715	Detoxification of Reactive Oxygen Species	0.157832129721192	-1.84622328089569	27	15	0.00474233322794815	3163	7167	7296,847,538,6647,2878,9588,5034,475,54205,25828,2950,2876,7001,5052,343	TXNRD1,CAT,ATP7A,SOD1,GPX3,PRDX6,P4HB,ATOX1,CYCS,TXN2,GSTP1,GPX1,PRDX2,PRDX1,AQP8
REACT_120996	Hyaluronan uptake and degradation	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	3373,3161,6548,55576,8372,960,8692	HYAL1,HMMR,SLC9A1,STAB2,HYAL3,CD44,HYAL2
REACT_11103	Nef mediated downregulation of MHC class I complex cell surface expression	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	567,10053,130340,653653,8905,3105,8907	B2M,AP1M2,AP1S3,LOC653653,AP1S2,HLA-A,AP1M1
REACT_13579	Apoptotic cleavage of cell adhesion  proteins	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	9414,7082,5317,999,1499,1832,1829	TJP2,TJP1,PKP1,CDH1,CTNNB1,DSP,DSG2
REACT_23810	Calnexin/calreticulin cycle	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	55757,811,821,5589,9695,11253,80267	UGGT2,CALR,CANX,PRKCSH,EDEM1,MAN1B1,EDEM3
REACT_11172	Vitamin B5 (pantothenate) metabolism	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	60496,8034,55229,79646,53354,60490,2194	AASDHPPT,SLC25A16,PANK4,PANK3,PANK1,PPCDC,FASN
REACT_916	Tryptophan catabolism	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	56267,883,8564,125061,8942,130013,23498	CCBL2,CCBL1,KMO,AFMID,KYNU,ACMSD,HAAO
REACT_120800	Dermatan sulfate biosynthesis	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	10090,113189,92126,633,63827,1462,1464	UST,CHST14,DSEL,BGN,BCAN,VCAN,CSPG4
REACT_150352	Synthesis of IP2, IP, and Ins in the cytosol	0.158796242506367	-1.84013339224774	11	7	0.00221308883970914	3163	7167	3612,51477,3631,3632,8867,3613,8821	IMPA1,ISYNA1,INPP4A,INPP5A,SYNJ1,IMPA2,INPP4B
REACT_115566	Cell Cycle	0.158898703826141	-1.83948836263988	538	249	0.0787227315839393	3163	7167	23353,126961,23291,4149,5684,2029,8349,4869,8358,11004,1026,891,7531,55651,7329,898,286826,4173,64682,1069,7465,4218,5111,5696,23225,10783,51343,26277,5701,10393,23047,8379,994,81929,7112,7277,8615,7311,1058,1454,1019,23133,85236,6241,3021,990,5577,672,10592,4171,983,3364,84296,4926,11190,25936,5714,55722,29935,8337,7029,128312,1870,7443,5528,25913,8086,55957,22995,51433,5689,22919,4659,63967,55355,1063,9493,3978,1111,8970,11243,4000,129401,7084,22897,11097,2010,80184,4174,4609,81876,4751,545,57804,79648,10426,79902,5686,993,4999,28227,9184,10112,5558,10274,4605,26003,22994,5685,7324,5704,84930,1778,5699,1859,996,2801,4957,10806,113130,8481,9688,4660,54820,8467,3619,333932,5425,5885,9134,5116,80321,10383,5721,83540,5424,5566,8290,132660,54386,595,25909,5687,4001,5518,55746,10213,10733,51434,80254,1032,3017,3306,23141,5983,902,8370,632,991,23224,114791,1871,6232,701,9088,8697,5861,1736,8021,995,79682,3796,5515,5529,8881,7514,122706,5525,51659,8607,79980,22981,5933,5709,84515,7444,8243,6500,23383,5981,10776,8338,3020,151648,55844,1453,4172,1781,6396,114799,55388,81620,10926,984,54908,55320,9491,91687,26271,6118,55920,387893,896,85378,1163,653604,699,3320,79019,10726,9837,25777,11130,1060,5692,140609,55755,5905,5710,7316,221496,64326,7175,5426,7015,7027,6418,472,147841,8636,80152,10197,55125,54892,11065,7013,8945,29945,55135	SUN1,HIST2H3C,FBXW11,MAX,PSMA3,ENSA,HIST2H2BE,NPM1,HIST1H3B,KIF2C,CDKN1A,CCNB1,YWHAE,NHP2,UBE2I,CCNE1,LIN9,MCM4,ANAPC1,CETN2,WEE1,RAB8A,PCNA,PSMB8,NUP210,NEK6,FZR1,TINF2,PSMC2,ANAPC10,PDS5B,MAD1L1,CDC25B,SEH1L,TMPO,TUBA4A,USO1,UBA52,CENPA,CSNK1E,CDK4,PHF8,HIST1H2BK,RRM2,H3F3B,CDC6,PRKAR2B,BRCA1,SMC2,MCM2,CDK1,HUS1,GINS4,NUMA1,CEP250,NSL1,PSMD8,CEP72,RPA4,HIST2H2AA3,TFDP2,HIST3H2BB,E2F2,VRK1,PPP2R5D,POT1,AAAS,LIN37,CEP152,ANAPC5,PSMB1,MAPRE1,PPP1R12A,CLSPN,HJURP,CENPF,KIF23,LIG1,CHEK1,HIST1H2BJ,PMF1,LMNA,NUP35,TK2,CEP164,NUPL2,EMD,CEP290,MCM5,MYC,RAB1B,NEK2,ATR,POLD4,MCPH1,TUBGCP3,NUP85,PSMA5,CDC25A,ORC2,PPP2R3B,BUB3,KIF20A,PRIM2,STAG1,MYBL2,GORASP2,AZI1,PSMA4,UBE2E1,PSMC4,MASTL,DYNC1H1,PSMB10,DYRK1A,CDC27,GOLGA2,ODF2,SDCCAG8,CDCA5,OFD1,NUP93,PPP1R12B,NDE1,SMARCA5,INCENP,HIST2H3A,POLD2,RAD21,CCNE2,PCNT,CEP70,TUBB4B,PSME2,NUF2,POLD1,PRKACA,HIST3H3,LIN54,TERF2IP,CCND1,AHCTF1,PSMA6,LMNB1,PPP2R1A,NUP133,PSMD14,PLK4,ANAPC7,CEP63,CDKN2D,HIST1H2BD,HSPA2,ANKLE2,RFC3,CCNH,HIST2H4A,BGLAP,CDC20,SYNE2,TUBGCP5,E2F3,RPS27,BUB1B,PKMYT1,CDC23,RAB1A,DKC1,NUP214,CDC25C,CENPU,KIF2A,PPP2CA,PPP2R5E,CDC16,XPO1,PSMB11,PPP2R5A,GINS2,RUVBL1,DSN1,NINL,RBL1,PSMD3,MCM8,VRK2,SMC1A,SKP1,MAU2,RFC1,ARPP19,HIST2H2AC,H3F3A,SGOL1,PPP2R2D,CSNK1D,MCM3,DYNC1I2,SEC13,ESCO1,MCM10,CDT1,DBF4,CDK11B,SPDL1,MIS18BP1,PSMF1,CENPL,FBXO5,RPA2,RCC2,SETD8,CCND3,TUBGCP6,CKS1B,HIST2H3D,BUB1,HSP90AA1,CENPM,NUDC,GINS1,SUN2,ZWINT,CENPC,PSMB4,NEK7,CDK5RAP2,RANGAP1,PSMD4,UBC,LEMD2,RFWD2,TPR,POLE,TERT,TFDP1,SET,ATM,SPC24,SSNA1,CENPT,PSME3,CEP192,NCAPG2,UBE2C,TERF1,BTRC,ANAPC4,WRAP53
REACT_115993	SHC1 events in ERBB2 signaling	0.159784496388358	-1.83392926920292	25	14	0.00442617767941827	3163	7167	685,1839,10718,6464,5894,2064,9542,3084,3845,2065,5605,3265,983,1956	BTC,HBEGF,NRG3,SHC1,RAF1,ERBB2,NRG2,NRG1,KRAS,ERBB3,MAP2K2,HRAS,CDK1,EGFR
REACT_19405	CTLA4 inhibitory signaling	0.161510522717644	-1.82318498229559	23	13	0.0041100221308884	3163	7167	5170,5515,5529,2534,5525,207,5518,942,10000,5781,4067,5528,6714	PDPK1,PPP2CA,PPP2R5E,FYN,PPP2R5A,AKT1,PPP2R1A,CD86,AKT3,PTPN11,LYN,PPP2R5D,SRC
REACT_1923	Purine salvage	0.16222928859423	-1.81874458273723	13	8	0.00252924438823901	3163	7167	271,353,272,4860,1716,132,1633,100	AMPD2,APRT,AMPD3,PNP,DGUOK,ADK,DCK,ADA
REACT_120756	Synthesis of PIPs at the early endosome membrane	0.16222928859423	-1.81874458273723	13	8	0.00252924438823901	3163	7167	4534,55300,3631,9110,8821,55697,5286,55361	MTM1,PI4K2B,INPP4A,MTMR4,INPP4B,VAC14,PIK3C2A,PI4K2A
REACT_23878	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.16222928859423	-1.81874458273723	13	8	0.00252924438823901	3163	7167	55757,811,9761,821,5589,9695,11253,80267	UGGT2,CALR,MLEC,CANX,PRKCSH,EDEM1,MAN1B1,EDEM3
REACT_12519	PECAM1 interactions	0.16222928859423	-1.81874458273723	13	8	0.00252924438823901	3163	7167	5335,2534,5777,3635,5781,3685,4067,6714	PLCG1,FYN,PTPN6,INPP5D,PTPN11,ITGAV,LYN,SRC
REACT_18348	Activation of Chaperones by ATF6-alpha	0.16222928859423	-1.81874458273723	13	8	0.00252924438823901	3163	7167	811,22926,4800,468,8720,3309,1649,51360	CALR,ATF6,NFYA,ATF4,MBTPS1,HSPA5,DDIT3,MBTPS2
REACT_15302	Mitochondrial tRNA aminoacylation	0.162926235923334	-1.8144577209503	21	12	0.00379386658235852	3163	7167	79731,10352,57505,55699,27068,55157,10667,23438,80222,51067,79587,54938	NARS2,WARS2,AARS2,IARS2,PPA2,DARS2,FARS2,HARS2,TARS2,YARS2,CARS2,SARS2
REACT_12599	ERK/MAPK targets	0.162926235923334	-1.8144577209503	21	12	0.00379386658235852	3163	7167	5515,6196,5518,6195,4205,5600,1846,9252,1432,5528,1849,4208	PPP2CA,RPS6KA2,PPP2R1A,RPS6KA1,MEF2A,MAPK11,DUSP4,RPS6KA5,MAPK14,PPP2R5D,DUSP7,MEF2C
REACT_15428	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.162926235923334	-1.8144577209503	21	12	0.00379386658235852	3163	7167	2147,3489,3484,3488,4313,3485,3483,3487,60676,3486,3817,2999	F2,IGFBP6,IGFBP1,IGFBP5,MMP2,IGFBP2,IGFALS,IGFBP4,PAPPA2,IGFBP3,KLK2,GZMH
REACT_121083	Hyaluronan metabolism	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	3161,55576,8372,3038,6548,3373,960,3037,8692	HMMR,STAB2,HYAL3,HAS3,SLC9A1,HYAL1,CD44,HAS2,HYAL2
REACT_22126	Activation of Nicotinic Acetylcholine Receptors	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	1139,55584,1137,1142,1141,8973,1135,1146,1145	CHRNA7,CHRNA9,CHRNA4,CHRNB3,CHRNB2,CHRNA6,CHRNA2,CHRNG,CHRNE
REACT_22149	Postsynaptic nicotinic acetylcholine receptors	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	1139,55584,1137,1142,1141,8973,1135,1146,1145	CHRNA7,CHRNA9,CHRNA4,CHRNB3,CHRNB2,CHRNA6,CHRNA2,CHRNG,CHRNE
REACT_14820	Metabolism of polyamines	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	6723,58478,2805,55256,4953,54498,262,6303,113451	SRM,ENOPH1,GOT1,ADI1,ODC1,SMOX,AMD1,SAT1,ADC
REACT_21285	Regulation of AMPK activity via LKB1	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	57521,5563,55437,5564,51422,5565,92335,5562,53632	RPTOR,PRKAA2,STRADB,PRKAB1,PRKAG2,PRKAB2,STRADA,PRKAA1,PRKAG3
REACT_15461	Acetylcholine Binding And Downstream Events	0.163872222646279	-1.80866828504324	15	9	0.00284539993676889	3163	7167	1139,55584,1137,1142,1141,8973,1135,1146,1145	CHRNA7,CHRNA9,CHRNA4,CHRNB3,CHRNB2,CHRNA6,CHRNA2,CHRNG,CHRNE
REACT_120726	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.16431129574261	-1.80599250558631	17	10	0.00316155548529877	3163	7167	2280,23370,57530,7311,5590,50848,7046,7048,7316,56288	FKBP1A,ARHGEF18,CGN,UBA52,PRKCZ,F11R,TGFBR1,TGFBR2,UBC,PARD3
REACT_1006	Polo-like kinase mediated events	0.16431129574261	-1.80599250558631	17	10	0.00316155548529877	3163	7167	132660,286826,993,7465,1063,4605,9088,891,995,55957	LIN54,LIN9,CDC25A,WEE1,CENPF,MYBL2,PKMYT1,CCNB1,CDC25C,LIN37
REACT_1946	PKA activation in glucagon signalling	0.16431129574261	-1.80599250558631	17	10	0.00316155548529877	3163	7167	114,111,5575,107,112,109,5577,5566,5567,113	ADCY8,ADCY5,PRKAR1B,ADCY1,ADCY6,ADCY3,PRKAR2B,PRKACA,PRKACB,ADCY7
REACT_147841	STING mediated induction of host immune responses	0.16431129574261	-1.80599250558631	17	10	0.00316155548529877	3163	7167	29110,51428,6778,5591,11277,3661,81030,340061,3428,7520	TBK1,DDX41,STAT6,PRKDC,TREX1,IRF3,ZBP1,TMEM173,IFI16,XRCC5
REACT_11065	Beta-catenin phosphorylation cascade	0.16431129574261	-1.80599250558631	17	10	0.00316155548529877	3163	7167	5515,5529,5525,1499,5518,8312,2932,324,1452,5528	PPP2CA,PPP2R5E,PPP2R5A,CTNNB1,PPP2R1A,AXIN1,GSK3B,APC,CSNK1A1,PPP2R5D
REACT_11045	Signaling by Wnt	0.165490693471349	-1.79884031854766	188	90	0.0284539993676889	3163	7167	5684,5721,51701,2782,324,5578,2783,5881,23002,55737,5331,161,5696,5687,1499,5518,5145,5216,5701,10213,1212,1856,815,8321,7311,2788,7476,7481,3710,4772,57216,548645,7478,5515,5529,122706,5525,7475,5714,5709,59345,8312,6500,2932,1855,5158,5528,27327,5689,57690,8325,6929,7472,27161,1452,9491,8323,5880,50999,2793,80326,8724,5593,51764,6885,89780,5330,7484,5686,7483,5692,2786,144165,7477,23513,6932,5710,5685,6934,7316,5704,5699,54361,160,81029,3708,1211,7855,10197,8945	PSMA3,PSME2,NLK,GNB1,APC,PRKCA,GNB2,RAC3,DAAM1,VPS35,PLCB3,AP2A2,PSMB8,PSMA6,CTNNB1,PPP2R1A,PDE6A,PFN1,PSMC2,PSMD14,CLTB,DVL2,CAMK2A,FZD1,UBA52,GNG7,WNT7A,WNT11,ITPR3,NFATC1,VANGL2,DNAJC25,WNT8A,PPP2CA,PPP2R5E,PSMB11,PPP2R5A,WNT6,PSMD8,PSMD3,GNB4,AXIN1,SKP1,GSK3B,DVL1,PDE6B,PPP2R5D,TNRC6A,PSMB1,TNRC6C,FZD8,TCF3,WNT2,AGO2,CSNK1A1,PSMF1,FZD6,RAC2,TMED5,GNGT2,WNT10A,SNX3,PRKG2,GNG13,MAP3K7,WNT3A,PLCB2,WNT9B,PSMA5,WNT9A,PSMB4,GNG4,PRICKLE1,WNT7B,SCRIB,TCF7,PSMD4,PSMA4,TCF7L2,UBC,PSMC4,PSMB10,WNT4,AP2A1,WNT5B,ITPR1,CLTA,FZD5,PSME3,BTRC
REACT_150154	Inositol phosphate metabolism	0.170212998418858	-1.77070469432036	46	24	0.00758773316471704	3163	7167	3612,3707,3636,89869,5333,9807,3635,51477,113026,8867,117283,5331,5335,64768,9651,3631,3632,5336,8821,5332,122618,5330,11165,3613	IMPA1,ITPKB,INPPL1,PLCZ1,PLCD1,IP6K1,INPP5D,ISYNA1,PLCD3,SYNJ1,IP6K3,PLCB3,PLCG1,IPPK,PLCH2,INPP4A,INPP5A,PLCG2,INPP4B,PLCB4,PLD4,PLCB2,NUDT3,IMPA2
REACT_13720	Cell death signalling via NRAGE, NRIF and NADE	0.172981354510737	-1.75457146768734	63	32	0.0101169775529561	3163	7167	7189,9826,8874,7410,7204,7531,27237,7409,57449,8878,23263,5664,89846,9181,7074,6453,10451,23370,7311,51107,1894,84033,23365,11214,4804,7316,29,121512,393,64857,2245,50649	TRAF6,ARHGEF11,ARHGEF7,VAV2,TRIO,YWHAE,ARHGEF16,VAV1,PLEKHG5,SQSTM1,MCF2L,PSEN2,FGD3,ARHGEF2,TIAM1,ITSN1,VAV3,ARHGEF18,UBA52,APH1A,ECT2,OBSCN,ARHGEF12,AKAP13,NGFR,UBC,ABR,FGD4,ARHGAP4,PLEKHG2,FGD1,ARHGEF4
REACT_22237	Netrin-1 signaling	0.173868670245355	-1.74945503345377	44	23	0.00727157761618716	3163	7167	4690,1793,285704,1630,7204,6091,6586,5747,6714,84448,148738,5335,2534,6477,57113,5781,6478,5306,22885,9423,90249,219699,56963	NCK1,DOCK1,RGMB,DCC,TRIO,ROBO1,SLIT3,PTK2,SRC,ABLIM2,HFE2,PLCG1,FYN,SIAH1,TRPC7,PTPN11,SIAH2,PITPNA,ABLIM3,NTN1,UNC5A,UNC5B,RGMA
REACT_152	Cell Cycle, Mitotic	0.174017438119103	-1.7485997657139	484	224	0.0708188428706924	3163	7167	126961,23291,4149,5684,2029,8349,8358,1026,11004,7531,891,898,4173,286826,4218,64682,7465,1069,5111,5696,23225,10783,5701,51343,10393,23047,8379,994,81929,7112,7277,1058,8615,7311,1019,23133,1454,85236,6241,990,5577,3021,10592,4171,983,84296,4926,25936,11190,5714,55722,29935,8337,128312,7029,7443,1870,5528,8086,55957,22995,51433,5689,22919,4659,1063,3978,9493,11243,8970,7084,129401,4000,11097,22897,2010,80184,4609,4174,81876,4751,79648,57804,79902,10426,5686,993,4999,28227,9184,10274,10112,5558,4605,26003,22994,5685,7324,5704,84930,1778,5699,1859,996,2801,4957,10806,113130,8481,9688,4660,54820,3619,5425,333932,5885,9134,5116,80321,10383,5721,83540,5424,8290,5566,132660,595,5687,25909,4001,5518,55746,10733,10213,51434,80254,1032,3017,23141,5983,8370,902,632,991,114791,1871,6232,701,9088,8697,5861,995,8021,79682,5515,3796,5529,122706,8881,7514,79980,51659,5525,5933,22981,5709,7444,84515,8243,6500,5981,23383,3020,8338,10776,151648,55844,4172,1453,1781,6396,55388,114799,81620,10926,984,54908,9491,91687,26271,6118,55920,387893,85378,896,1163,653604,699,3320,79019,10726,9837,11130,1060,5692,140609,55755,5905,5710,7316,221496,7175,5426,6418,7027,147841,8636,80152,55125,10197,11065,54892,29945,8945	HIST2H3C,FBXW11,MAX,PSMA3,ENSA,HIST2H2BE,HIST1H3B,CDKN1A,KIF2C,YWHAE,CCNB1,CCNE1,MCM4,LIN9,RAB8A,ANAPC1,WEE1,CETN2,PCNA,PSMB8,NUP210,NEK6,PSMC2,FZR1,ANAPC10,PDS5B,MAD1L1,CDC25B,SEH1L,TMPO,TUBA4A,CENPA,USO1,UBA52,CDK4,PHF8,CSNK1E,HIST1H2BK,RRM2,CDC6,PRKAR2B,H3F3B,SMC2,MCM2,CDK1,GINS4,NUMA1,NSL1,CEP250,PSMD8,CEP72,RPA4,HIST2H2AA3,HIST3H2BB,TFDP2,VRK1,E2F2,PPP2R5D,AAAS,LIN37,CEP152,ANAPC5,PSMB1,MAPRE1,PPP1R12A,CENPF,LIG1,KIF23,PMF1,HIST1H2BJ,TK2,NUP35,LMNA,NUPL2,CEP164,EMD,CEP290,MYC,MCM5,RAB1B,NEK2,MCPH1,POLD4,NUP85,TUBGCP3,PSMA5,CDC25A,ORC2,PPP2R3B,BUB3,STAG1,KIF20A,PRIM2,MYBL2,GORASP2,AZI1,PSMA4,UBE2E1,PSMC4,MASTL,DYNC1H1,PSMB10,DYRK1A,CDC27,GOLGA2,ODF2,SDCCAG8,CDCA5,OFD1,NUP93,PPP1R12B,NDE1,INCENP,POLD2,HIST2H3A,RAD21,CCNE2,PCNT,CEP70,TUBB4B,PSME2,NUF2,POLD1,HIST3H3,PRKACA,LIN54,CCND1,PSMA6,AHCTF1,LMNB1,PPP2R1A,NUP133,PLK4,PSMD14,ANAPC7,CEP63,CDKN2D,HIST1H2BD,ANKLE2,RFC3,HIST2H4A,CCNH,BGLAP,CDC20,TUBGCP5,E2F3,RPS27,BUB1B,PKMYT1,CDC23,RAB1A,CDC25C,NUP214,CENPU,PPP2CA,KIF2A,PPP2R5E,PSMB11,CDC16,XPO1,DSN1,GINS2,PPP2R5A,RBL1,NINL,PSMD3,VRK2,MCM8,SMC1A,SKP1,RFC1,MAU2,H3F3A,HIST2H2AC,ARPP19,SGOL1,PPP2R2D,MCM3,CSNK1D,DYNC1I2,SEC13,MCM10,ESCO1,CDT1,DBF4,CDK11B,SPDL1,PSMF1,CENPL,FBXO5,RPA2,RCC2,SETD8,TUBGCP6,CCND3,CKS1B,HIST2H3D,BUB1,HSP90AA1,CENPM,NUDC,GINS1,ZWINT,CENPC,PSMB4,NEK7,CDK5RAP2,RANGAP1,PSMD4,UBC,LEMD2,TPR,POLE,SET,TFDP1,SPC24,SSNA1,CENPT,CEP192,PSME3,UBE2C,NCAPG2,ANAPC4,BTRC
REACT_22442	Interleukin-1 signaling	0.177615882216698	-1.72813202552659	42	22	0.00695542206765729	3163	7167	4215,7189,9978,387522,1326,246330,57162,54472,3554,8517,8878,3654,23118,4790,3551,64127,6500,3557,6885,79155,3556,8945	MAP3K3,TRAF6,RBX1,TMEM189-UBE2V1,MAP3K8,PELI3,PELI1,TOLLIP,IL1R1,IKBKG,SQSTM1,IRAK1,TAB2,NFKB1,IKBKB,NOD2,SKP1,IL1RN,MAP3K7,TNIP2,IL1RAP,BTRC
REACT_22339	RNA Polymerase III Abortive And Retractive Initiation	0.181456165357886	-1.70674116762593	40	21	0.00663926651912741	3163	7167	2976,5441,9328,6908,5440,84265,5451,7702,6618,6621,51728,4784,661,55718,55290,5434,4782,5437,2972,11178,10302	GTF3C2,POLR2L,GTF3C5,TBP,POLR2K,POLR3GL,POU2F1,ZNF143,SNAPC2,SNAPC4,POLR3K,NFIX,POLR3D,POLR3E,BRF2,POLR2E,NFIC,POLR2H,BRF1,LZTS1,SNAPC5
REACT_1371	RNA Polymerase III Transcription	0.181456165357886	-1.70674116762593	40	21	0.00663926651912741	3163	7167	2976,5441,9328,6908,5440,84265,5451,7702,6618,6621,51728,4784,661,55718,55290,5434,4782,5437,2972,11178,10302	GTF3C2,POLR2L,GTF3C5,TBP,POLR2K,POLR3GL,POU2F1,ZNF143,SNAPC2,SNAPC4,POLR3K,NFIX,POLR3D,POLR3E,BRF2,POLR2E,NFIC,POLR2H,BRF1,LZTS1,SNAPC5
REACT_24994	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements	0.182074238072268	-1.70334077357856	89	44	0.0139108441353146	3163	7167	5689,5684,5721,677,5578,1432,5073,9491,5696,5687,5580,56915,5701,10213,3184,55802,5600,54512,26986,5686,7311,5692,207,3312,5710,8021,5685,7316,167227,3304,5704,9261,5699,1981,7514,122706,5714,5709,6418,8570,7534,10197,3315,3842	PSMB1,PSMA3,PSME2,ZFP36L1,PRKCA,MAPK14,PARN,PSMF1,PSMB8,PSMA6,PRKCD,EXOSC5,PSMC2,PSMD14,HNRNPD,DCP1A,MAPK11,EXOSC4,PABPC1,PSMA5,UBA52,PSMB4,AKT1,HSPA8,PSMD4,NUP214,PSMA4,UBC,DCP2,HSPA1B,PSMC4,MAPKAPK2,PSMB10,EIF4G1,XPO1,PSMB11,PSMD8,PSMD3,SET,KHSRP,YWHAZ,PSME3,HSPB1,TNPO1
REACT_21267	Mitotic G1-G1/S phases	0.186765880750525	-1.67789942109862	139	67	0.0211824217515017	3163	7167	9134,5689,4149,55388,5684,5721,81620,10926,1026,891,9491,898,7084,26271,132660,286826,595,6118,4173,7465,5111,5696,5687,5518,4174,4609,896,5701,10213,1163,1032,5686,993,4999,7311,28227,902,5692,5558,1019,4605,1871,6241,990,9088,5710,4171,983,5685,7316,5704,5515,5699,1859,5426,5933,5714,5709,7027,84515,29935,6500,10197,7029,1870,4172,55957	CCNE2,PSMB1,MAX,MCM10,PSMA3,PSME2,CDT1,DBF4,CDKN1A,CCNB1,PSMF1,CCNE1,TK2,FBXO5,LIN54,LIN9,CCND1,RPA2,MCM4,WEE1,PCNA,PSMB8,PSMA6,PPP2R1A,MCM5,MYC,CCND3,PSMC2,PSMD14,CKS1B,CDKN2D,PSMA5,CDC25A,ORC2,UBA52,PPP2R3B,CCNH,PSMB4,PRIM2,CDK4,MYBL2,E2F3,RRM2,CDC6,PKMYT1,PSMD4,MCM2,CDK1,PSMA4,UBC,PSMC4,PPP2CA,PSMB10,DYRK1A,POLE,RBL1,PSMD8,PSMD3,TFDP1,MCM8,RPA4,SKP1,PSME3,TFDP2,E2F2,MCM3,LIN37
REACT_19344	Costimulation by the CD28 family	0.186949978672067	-1.67691419164264	72	36	0.0113815997470756	3163	7167	920,942,2475,1326,79109,29851,4067,6714,3113,7409,3123,5133,5518,919,5296,117145,5290,5781,8503,151888,9020,64223,5170,5058,207,5777,5295,5515,5529,57761,2534,5525,10000,23308,5528,940	CD4,CD86,MTOR,MAP3K8,MAPKAP1,ICOS,LYN,SRC,HLA-DPA1,VAV1,HLA-DRB1,PDCD1,PPP2R1A,CD247,PIK3R2,THEM4,PIK3CA,PTPN11,PIK3R3,BTLA,MAP3K14,MLST8,PDPK1,PAK1,AKT1,PTPN6,PIK3R1,PPP2CA,PPP2R5E,TRIB3,FYN,PPP2R5A,AKT3,ICOSLG,PPP2R5D,CD28
REACT_15295	Opioid Signalling	0.190257566091177	-1.65937651382651	85	42	0.0132785330382548	3163	7167	5321,2774,5137,2782,5578,5143,5566,2783,5331,1020,5136,5518,2781,2793,5580,109,112,51764,5499,5144,1385,2771,5330,5567,113,2788,5575,107,2786,5577,3710,548645,5515,111,59345,114,3708,346562,5332,2779,5533,5528	PLA2G4A,GNAL,PDE1C,GNB1,PRKCA,PDE4C,PRKACA,GNB2,PLCB3,CDK5,PDE1A,PPP2R1A,GNAZ,GNGT2,PRKCD,ADCY3,ADCY6,GNG13,PPP1CA,PDE4D,CREB1,GNAI2,PLCB2,PRKACB,ADCY7,GNG7,PRKAR1B,ADCY1,GNG4,PRKAR2B,ITPR3,DNAJC25,PPP2CA,ADCY5,GNB4,ADCY8,ITPR1,GNAT3,PLCB4,GNAT1,PPP3CC,PPP2R5D
REACT_1538	Cell Cycle Checkpoints	0.191628795122015	-1.65219513704425	124	60	0.0189693329117926	3163	7167	9134,5689,51433,55388,5684,63967,5721,10926,1111,1026,891,9491,898,4173,6118,64682,7465,5687,5696,4174,5701,10393,8379,10213,545,51434,5686,993,4999,7311,5983,5692,9184,991,990,701,9088,4171,8697,5710,995,983,5685,7324,3364,7316,5704,64326,5699,122706,8881,996,5709,5714,84515,472,10197,11065,4172,29945	CCNE2,PSMB1,ANAPC5,MCM10,PSMA3,CLSPN,PSME2,DBF4,CHEK1,CDKN1A,CCNB1,PSMF1,CCNE1,MCM4,RPA2,ANAPC1,WEE1,PSMA6,PSMB8,MCM5,PSMC2,ANAPC10,MAD1L1,PSMD14,ATR,ANAPC7,PSMA5,CDC25A,ORC2,UBA52,RFC3,PSMB4,BUB3,CDC20,CDC6,BUB1B,PKMYT1,MCM2,CDC23,PSMD4,CDC25C,CDK1,PSMA4,UBE2E1,HUS1,UBC,PSMC4,RFWD2,PSMB10,PSMB11,CDC16,CDC27,PSMD3,PSMD8,MCM8,ATM,PSME3,UBE2C,MCM3,ANAPC4
REACT_25271	Negative regulators of RIG-I/MDA5 signaling	0.193542777919168	-1.64225671642801	34	18	0.00569079987353778	3163	7167	7323,29110,1540,7311,7128,79671,9140,54941,3661,7316,9641,7706,5300,7322,84166,7187,57506,9474	UBE2D3,TBK1,CYLD,UBA52,TNFAIP3,NLRX1,ATG12,RNF125,IRF3,UBC,IKBKE,TRIM25,PIN1,UBE2D2,NLRC5,TRAF3,MAVS,ATG5
REACT_2253	Global Genomic NER (GG-NER)	0.193542777919168	-1.64225671642801	34	18	0.00569079987353778	3163	7167	1643,2967,2067,5983,902,3978,2072,5424,6118,5111,5426,2968,5887,7507,5981,57804,1642,5425	DDB2,GTF2H3,ERCC1,RFC3,CCNH,LIG1,ERCC4,POLD1,RPA2,PCNA,POLE,GTF2H4,RAD23B,XPA,RFC1,POLD4,DDB1,POLD2
REACT_23887	Aquaporin-mediated transport	0.193668392346962	-1.64160790026852	53	27	0.00853619981030667	3163	7167	4645,89872,2788,5575,358,107,2786,2782,5577,360,363,366,5566,8766,2783,548645,364,2793,114,111,59345,112,109,51764,5567,343,113	MYO5B,AQP10,GNG7,PRKAR1B,AQP1,ADCY1,GNG4,GNB1,PRKAR2B,AQP3,AQP6,AQP9,PRKACA,RAB11A,GNB2,DNAJC25,AQP7,GNGT2,ADCY8,ADCY5,GNB4,ADCY6,ADCY3,GNG13,PRKACB,AQP8,ADCY7
REACT_75899	TWIK-releated acid-sensitive K+ channel (TASK)	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	51305,3777	KCNK9,KCNK3
REACT_1002	Proline catabolism	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	8659,5625	ALDH4A1,PRODH
REACT_115589	Cysteine formation from homocysteine	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	875,1491	CBS,CTH
REACT_75850	TWIK-related alkaline pH activated K+ channel (TALK)	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	89822,83795	KCNK17,KCNK16
REACT_15548	Enzymatic degradation of dopamine by COMT	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	4128,1312	MAOA,COMT
REACT_9434	vRNP Assembly	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	3320,3843	HSP90AA1,IPO5
REACT_18	mRNA Editing: A to I Conversion	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	104,103	ADARB1,ADAR
REACT_6270	Virus Assembly and Release	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	811,821	CALR,CANX
REACT_6277	Assembly of Viral Components at the Budding Site	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	811,821	CALR,CANX
REACT_120785	Hydrolysis of LPE	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	8605,56261	PLA2G4C,GPCPD1
REACT_11213	Nicotinamide salvaging	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	93100,10135	NAPRT1,NAMPT
REACT_121000	Synthesis of PI	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	10423,1040	CDIPT,CDS1
REACT_939	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	6888,7086	TALDO1,TKT
REACT_1231	C6 deamination of adenosine	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	104,103	ADARB1,ADAR
REACT_707	Activation and oligomerization of BAK protein	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	578,637	BAK1,BID
REACT_23809	Transport of Glycerol from Adipocytes to the Liver by Aquaporins	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	366,364	AQP9,AQP7
REACT_6173	Inhibition of Host mRNA Processing and RNA Silencing	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	10898,8106	CPSF4,PABPN1
REACT_6905	Interactions of Tat with host cellular proteins	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	904,1025	CCNT1,CDK9
REACT_1966	Formation of editosomes by ADAR proteins	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	104,103	ADARB1,ADAR
REACT_11037	Estrogen biosynthesis	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	3292,1588	HSD17B1,CYP19A1
REACT_15511	Enzymatic degradation of Dopamine by monoamine oxidase	0.194736270892585	-1.63610909277486	2	2	0.000632311097059753	3163	7167	4128,1312	MAOA,COMT
REACT_17044	Muscle contraction	0.198211515661295	-1.61842055755663	51	26	0.00822004426177679	3163	7167	7140,7134,7136,7125,10580,5829,7170,7169,7094,25802,7171,10174,7431,88,7135,4607,800,4638,4621,7139,8557,3672,7168,7414,103910,4634	TNNT3,TNNC1,TNNI2,TNNC2,SORBS1,PXN,TPM3,TPM2,TLN1,LMOD1,TPM4,SORBS3,VIM,ACTN2,TNNI1,MYBPC3,CALD1,MYLK,MYH3,TNNT2,TCAP,ITGA1,TPM1,VCL,MYL12B,MYL3
REACT_23876	Platelet homeostasis	0.198926378653082	-1.61482047922562	81	40	0.0126462219411951	3163	7167	5321,3779,5023,489,2782,1432,2783,5139,5136,5518,2793,10846,5781,5593,84876,51764,492,5777,5739,3778,2788,491,2786,10335,3710,5138,548645,5515,5529,2268,5525,59345,2983,57113,3708,4843,5528,5152,7804,493	PLA2G4A,KCNMB1,P2RX1,ATP2A3,GNB1,MAPK14,GNB2,PDE3A,PDE1A,PPP2R1A,GNGT2,PDE10A,PTPN11,PRKG2,ORAI1,GNG13,ATP2B3,PTPN6,PTGIR,KCNMA1,GNG7,ATP2B2,GNG4,MRVI1,ITPR3,PDE2A,DNAJC25,PPP2CA,PPP2R5E,FGR,PPP2R5A,GNB4,GUCY1B3,TRPC7,ITPR1,NOS2,PPP2R5D,PDE9A,LRP8,ATP2B4
REACT_147694	DAP12 interactions	0.20059083259742	-1.60648810441174	179	85	0.0268732216250395	3163	7167	685,1839,7249,942,2475,5894,5137,2064,9542,1026,3937,5578,5566,7409,5154,5136,6464,5336,5296,5290,109,8503,3815,5567,5159,113,64223,27040,2931,207,2249,107,5577,3710,983,2260,2246,5335,2534,10718,114,4254,2932,3084,27327,57690,27161,7410,79109,567,23239,284266,2261,9436,117145,5580,5781,112,2065,3107,1385,6850,22914,3802,6199,5170,2264,10451,2254,3164,27006,5295,5575,3845,5605,1956,2248,57761,111,10000,26281,8817,3708,3265,940	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,PDE1C,ERBB2,NRG2,CDKN1A,LCP2,PRKCA,PRKACA,VAV1,PDGFA,PDE1A,SHC1,PLCG2,PIK3R2,PIK3CA,ADCY3,PIK3R3,KIT,PRKACB,PDGFRB,ADCY7,MLST8,LAT,GSK3A,AKT1,FGF4,ADCY1,PRKAR2B,ITPR3,CDK1,FGFR1,FGF1,PLCG1,FYN,NRG3,ADCY8,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,VAV2,MAPKAP1,B2M,PHLPP1,SIGLEC15,FGFR3,NCR2,THEM4,PRKCD,PTPN11,ADCY6,ERBB3,HLA-C,CREB1,SYK,KLRK1,KIR2DL1,RPS6KB2,PDPK1,FGFR4,VAV3,FGF9,NR4A1,FGF22,PIK3R1,PRKAR1B,KRAS,MAP2K2,EGFR,FGF3,TRIB3,ADCY5,AKT3,FGF20,FGF18,ITPR1,HRAS,CD28
REACT_11057	Metabolism of steroid hormones and vitamin D	0.202062324912597	-1.59917908999808	30	16	0.00505848877647803	3163	7167	3292,1591,1588,1589,6716,1585,1584,1583,80765,3290,3972,79644,134429,120227,5641,51144	HSD17B1,CYP24A1,CYP19A1,CYP21A2,SRD5A2,CYP11B2,CYP11B1,CYP11A1,STARD5,HSD11B1,LHB,SRD5A3,STARD4,CYP2R1,LGMN,HSD17B12
REACT_150331	Molecules associated with elastic fibres	0.202062324912597	-1.59917908999808	30	16	0.00505848877647803	3163	7167	650,4052,10516,2199,3696,7448,27302,3688,4053,4237,3685,7042,2192,3694,30008,4054	BMP2,LTBP1,FBLN5,FBLN2,ITGB8,VTN,BMP10,ITGB1,LTBP2,MFAP2,ITGAV,TGFB2,FBLN1,ITGB6,EFEMP2,LTBP3
REACT_9480	Gap junction trafficking and regulation	0.202062324912597	-1.59917908999808	30	16	0.00505848877647803	3163	7167	2700,57165,1601,219770,1785,2703,2707,7082,1211,127534,1212,2709,6714,84694,125111,2702	GJA3,GJC2,DAB2,GJD4,DNM2,GJA8,GJB3,TJP1,CLTA,GJB4,CLTB,GJB5,SRC,GJA10,GJD3,GJA5
REACT_15307	Ca-dependent events	0.202062324912597	-1.59917908999808	30	16	0.00505848877647803	3163	7167	5321,5575,5137,107,5577,5578,5566,5136,111,114,5580,112,109,1385,5567,113	PLA2G4A,PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,PRKACA,PDE1A,ADCY5,ADCY8,PRKCD,ADCY6,ADCY3,CREB1,PRKACB,ADCY7
REACT_121120	Keratan sulfate biosynthesis	0.206448687041858	-1.57770338636095	28	15	0.00474233322794815	3163	7167	93010,6484,2331,4166,8534,176,2683,6483,8703,8702,10402,6482,6487,5549,10331	B3GNT7,ST3GAL4,FMOD,CHST6,CHST1,ACAN,B4GALT1,ST3GAL2,B4GALT3,B4GALT4,ST3GAL6,ST3GAL1,ST3GAL3,PRELP,B3GNT3
REACT_8030	Extension of Telomeres	0.206448687041858	-1.57770338636095	28	15	0.00474233322794815	3163	7167	6118,5983,5111,5426,5558,8607,7015,3978,5981,55651,1736,5424,57804,5425,55135	RPA2,RFC3,PCNA,POLE,PRIM2,RUVBL1,TERT,LIG1,RFC1,NHP2,DKC1,POLD1,POLD4,POLD2,WRAP53
REACT_9000	Calmodulin induced events	0.206448687041858	-1.57770338636095	28	15	0.00474233322794815	3163	7167	5136,114,111,5580,5575,5137,107,109,112,5577,1385,5578,5566,5567,113	PDE1A,ADCY8,ADCY5,PRKCD,PRKAR1B,PDE1C,ADCY1,ADCY3,ADCY6,PRKAR2B,CREB1,PRKCA,PRKACA,PRKACB,ADCY7
REACT_9053	CaM pathway	0.206448687041858	-1.57770338636095	28	15	0.00474233322794815	3163	7167	5136,114,111,5580,5575,5137,107,109,112,5577,1385,5578,5566,5567,113	PDE1A,ADCY8,ADCY5,PRKCD,PRKAR1B,PDE1C,ADCY1,ADCY3,ADCY6,PRKAR2B,CREB1,PRKCA,PRKACA,PRKACB,ADCY7
REACT_18355	Activation of Genes by ATF4	0.210907048865984	-1.55633776926796	26	14	0.00442617767941827	3163	7167	4800,440,468,3484,3576,56915,8570,467,22926,54512,5073,167227,1649,9709	NFYA,ASNS,ATF4,IGFBP1,IL8,EXOSC5,KHSRP,ATF3,ATF6,EXOSC4,PARN,DCP2,DDIT3,HERPUD1
REACT_1109	Insulin receptor recycling	0.210907048865984	-1.55633776926796	26	14	0.00442617767941827	3163	7167	533,3643,10312,127124,90423,527,528,723961,51606,8992,9114,3630,525,9550	ATP6V0B,INSR,TCIRG1,ATP6V1G3,ATP6V1E2,ATP6V0C,ATP6V1C1,INS-IGF2,ATP6V1H,ATP6V0E1,ATP6V0D1,INS,ATP6V1B1,ATP6V1G1
REACT_121408	A tetrasaccharide linker sequence is required for GAG synthesis	0.210907048865984	-1.55633776926796	26	14	0.00442617767941827	3163	7167	126792,375790,3339,1462,6385,26229,9672,633,63827,6382,2817,11285,27087,1464	B3GALT6,AGRN,HSPG2,VCAN,SDC4,B3GAT3,SDC3,BGN,BCAN,SDC1,GPC1,B4GALT7,B3GAT1,CSPG4
REACT_21281	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.210907048865984	-1.55633776926796	26	14	0.00442617767941827	3163	7167	3146,7189,8517,3654,23118,4792,4790,3551,1660,64127,6885,4791,351,6283	HMGB1,TRAF6,IKBKG,IRAK1,TAB2,NFKBIA,NFKB1,IKBKB,DHX9,NOD2,MAP3K7,NFKB2,APP,S100A12
REACT_118764	ZBP1(DAI) mediated induction of type I IFNs	0.210907048865984	-1.55633776926796	26	14	0.00442617767941827	3163	7167	3146,8517,29110,4792,4790,3551,1660,8737,3661,81030,4791,351,340061,6283	HMGB1,IKBKG,TBK1,NFKBIA,NFKB1,IKBKB,DHX9,RIPK1,IRF3,ZBP1,NFKB2,APP,TMEM173,S100A12
REACT_115596	Signaling by ERBB4	0.214279095985337	-1.54047592682587	149	71	0.0224470439456212	3163	7167	685,1839,7249,942,2475,5894,2064,9542,1026,7409,5154,6464,5296,5664,5290,8503,3815,5159,64223,7311,2931,207,51107,9978,2249,983,2260,2246,2534,10718,23118,4254,2932,6500,3084,27327,57690,27161,79109,23239,2688,2261,5618,117145,5781,3717,11059,2065,1385,6199,5170,2264,2254,6868,3164,27006,5295,3845,5605,7316,1956,2248,57761,51741,10000,26281,8817,6776,3265,940,8945	BTC,HBEGF,TSC2,CD86,MTOR,RAF1,ERBB2,NRG2,CDKN1A,VAV1,PDGFA,SHC1,PIK3R2,PSEN2,PIK3CA,PIK3R3,KIT,PDGFRB,MLST8,UBA52,GSK3A,AKT1,APH1A,RBX1,FGF4,CDK1,FGFR1,FGF1,FYN,NRG3,TAB2,KITLG,GSK3B,SKP1,NRG1,TNRC6A,TNRC6C,AGO2,MAPKAP1,PHLPP1,GH1,FGFR3,PRLR,THEM4,PTPN11,JAK2,WWP1,ERBB3,CREB1,RPS6KB2,PDPK1,FGFR4,FGF9,ADAM17,NR4A1,FGF22,PIK3R1,KRAS,MAP2K2,UBC,EGFR,FGF3,TRIB3,WWOX,AKT3,FGF20,FGF18,STAT5A,HRAS,CD28,BTRC
REACT_20514	Deadenylation of mRNA	0.215421413690239	-1.53515910559734	24	13	0.0041100221308884	3163	7167	1981,25904,1975,23019,9337,57472,1973,85456,5073,1977,26986,9924,4849	EIF4G1,CNOT10,EIF4B,CNOT1,CNOT8,CNOT6,EIF4A1,TNKS1BP1,PARN,EIF4E,PABPC1,PAN2,CNOT3
REACT_111133	Growth hormone receptor signaling	0.215421413690239	-1.53515910559734	24	13	0.0041100221308884	3163	7167	1154,6868,5770,8651,5777,5618,8835,3717,6776,4067,2688,6774,9021	CISH,ADAM17,PTPN1,SOCS1,PTPN6,PRLR,SOCS2,JAK2,STAT5A,LYN,GH1,STAT3,SOCS3
REACT_24969	TRAF6 mediated NF-kB activation	0.215421413690239	-1.53515910559734	24	13	0.0041100221308884	3163	7167	3146,7189,8517,7706,7186,4792,4790,3551,1660,57506,4791,351,6283	HMGB1,TRAF6,IKBKG,TRIM25,TRAF2,NFKBIA,NFKB1,IKBKB,DHX9,MAVS,NFKB2,APP,S100A12
REACT_1783	G1/S Transition	0.217084420439075	-1.52746896681444	112	54	0.0170723996206133	3163	7167	9134,5689,55388,4149,5684,5721,81620,10926,1026,891,9491,898,7084,26271,4173,6118,7465,5687,5111,5696,5518,4609,4174,5701,10213,1163,5686,993,4999,7311,28227,5692,5558,902,6241,990,9088,4171,5710,983,5685,7316,5704,5515,5699,5426,5709,5714,7027,84515,29935,6500,10197,4172	CCNE2,PSMB1,MCM10,MAX,PSMA3,PSME2,CDT1,DBF4,CDKN1A,CCNB1,PSMF1,CCNE1,TK2,FBXO5,MCM4,RPA2,WEE1,PSMA6,PCNA,PSMB8,PPP2R1A,MYC,MCM5,PSMC2,PSMD14,CKS1B,PSMA5,CDC25A,ORC2,UBA52,PPP2R3B,PSMB4,PRIM2,CCNH,RRM2,CDC6,PKMYT1,MCM2,PSMD4,CDK1,PSMA4,UBC,PSMC4,PPP2CA,PSMB10,POLE,PSMD3,PSMD8,TFDP1,MCM8,RPA4,SKP1,PSME3,MCM3
REACT_16956	Formation of tubulin folding intermediates by CCT/TriC	0.219967237024546	-1.51427666633555	22	12	0.00379386658235852	3163	7167	22948,10576,7280,7278,10383,4157,7203,10574,84617,10381,10376,7277	CCT5,CCT2,TUBB2A,TUBA3C,TUBB4B,MC1R,CCT3,CCT7,TUBB6,TUBB3,TUBA1B,TUBA4A
REACT_118707	Regulation of Complement cascade	0.219967237024546	-1.51427666633555	22	12	0.00379386658235852	3163	7167	718,733,4179,10878,1604,3075,7448,729,1378,5627,722,725	C3,C8G,CD46,CFHR3,CD55,CFH,VTN,C6,CR1,PROS1,C4BPA,C4BPB
REACT_150314	Mitotic Metaphase and Anaphase	0.220523154192276	-1.51175258193344	180	85	0.0268732216250395	3163	7167	5684,5721,83540,11004,64682,5696,5687,25909,4001,5518,55746,5701,10393,23047,8379,10213,51434,81929,7112,23141,7311,1058,632,991,6232,701,8697,79682,3796,5515,5529,8881,7514,122706,5525,25936,79980,5714,5709,7444,8243,151648,7443,5528,51433,5689,6396,22919,1063,11243,54908,9491,91687,4000,26271,55920,2010,699,79019,79902,5686,10726,11130,1060,9184,10274,5692,5905,5710,5685,7316,7324,5704,221496,5699,996,113130,147841,80152,54820,10197,3619,11065,29945,5885	PSMA3,PSME2,NUF2,KIF2C,ANAPC1,PSMB8,PSMA6,AHCTF1,LMNB1,PPP2R1A,NUP133,PSMC2,ANAPC10,PDS5B,MAD1L1,PSMD14,ANAPC7,SEH1L,TMPO,ANKLE2,UBA52,CENPA,BGLAP,CDC20,RPS27,BUB1B,CDC23,CENPU,KIF2A,PPP2CA,PPP2R5E,CDC16,XPO1,PSMB11,PPP2R5A,NSL1,DSN1,PSMD8,PSMD3,VRK2,SMC1A,SGOL1,VRK1,PPP2R5D,ANAPC5,PSMB1,SEC13,MAPRE1,CENPF,PMF1,SPDL1,PSMF1,CENPL,LMNA,FBXO5,RCC2,EMD,BUB1,CENPM,NUP85,PSMA5,NUDC,ZWINT,CENPC,BUB3,STAG1,PSMB4,RANGAP1,PSMD4,PSMA4,UBC,UBE2E1,PSMC4,LEMD2,PSMB10,CDC27,CDCA5,SPC24,CENPT,NDE1,PSME3,INCENP,UBE2C,ANAPC4,RAD21
REACT_25078	Interferon gamma signaling	0.223033057812256	-1.50043527719811	71	35	0.0110654441985457	3163	7167	5724,567,3661,3383,3105,5771,3123,3113,8554,3662,5770,6672,8651,2209,5580,10379,5781,2210,3717,3107,960,818,815,4502,3460,5777,3664,4261,9021,817,816,10437,3665,3394,3659	PTAFR,B2M,IRF3,ICAM1,HLA-A,PTPN2,HLA-DRB1,HLA-DPA1,PIAS1,IRF4,PTPN1,SP100,SOCS1,FCGR1A,PRKCD,IRF9,PTPN11,FCGR1B,JAK2,HLA-C,CD44,CAMK2G,CAMK2A,MT2A,IFNGR2,PTPN6,IRF6,CIITA,SOCS3,CAMK2D,CAMK2B,IFI30,IRF7,IRF8,IRF1
REACT_20563	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.223409955023035	-1.49874683191178	41	21	0.00663926651912741	3163	7167	5170,5923,6237,84254,6195,5894,2902,107,88,5566,817,2890,6196,816,114,109,1385,3265,5567,815,818	PDPK1,RASGRF1,RRAS,CAMKK1,RPS6KA1,RAF1,GRIN1,ADCY1,ACTN2,PRKACA,CAMK2D,GRIA1,RPS6KA2,CAMK2B,ADCY8,ADCY3,CREB1,HRAS,PRKACB,CAMK2A,CAMK2G
REACT_115852	Signaling by constitutively active EGFR	0.2245069396152	-1.49384866085129	20	11	0.00347771103382864	3163	7167	5335,7311,6464,5295,5290,3845,3320,867,3265,1956,7316	PLCG1,UBA52,SHC1,PIK3R1,PIK3CA,KRAS,HSP90AA1,CBL,HRAS,EGFR,UBC
REACT_21310	Phospholipase C-mediated cascade	0.225301798720223	-1.49031444790859	56	28	0.00885235535883655	3163	7167	2264,2254,2249,27006,5575,5137,107,5577,5578,3710,5566,2260,2248,2246,5335,2261,5136,114,111,26281,8817,5580,3708,109,112,1385,5567,113	FGFR4,FGF9,FGF4,FGF22,PRKAR1B,PDE1C,ADCY1,PRKAR2B,PRKCA,ITPR3,PRKACA,FGFR1,FGF3,FGF1,PLCG1,FGFR3,PDE1A,ADCY8,ADCY5,FGF20,FGF18,PRKCD,ITPR1,ADCY3,ADCY6,CREB1,PRKACB,ADCY7
REACT_19400	Golgi Associated Vesicle Biogenesis	0.225301798720223	-1.49031444790859	56	28	0.00885235535883655	3163	7167	3482,9698,6643,63915,9026,8905,3312,10717,7163,375,9685,51429,7164,55330,5286,7037,10053,653653,8907,1785,84062,408,1211,2580,130340,8775,5878,23557	IGF2R,PUM1,SNX2,BLOC1S5,HIP1R,AP1S2,HSPA8,AP4B1,TPD52,ARF1,CLINT1,SNX9,TPD52L1,BLOC1S4,PIK3C2A,TFRC,AP1M2,LOC653653,AP1M1,DNM2,DTNBP1,ARRB1,CLTA,GAK,AP1S3,NAPA,RAB5C,SNAPIN
REACT_6802	Innate Immune System	0.225327678786662	-1.49019958606418	611	279	0.0882073980398356	3163	7167	22861,71,7249,5589,387522,9542,5578,613210,51728,5645,63916,5290,1785,722,7100,1849,64223,27040,7311,5577,948,5335,7454,64145,114,3984,1675,64127,4254,2932,5437,11178,4208,81844,728358,9208,3146,5440,64170,7410,1660,3725,4153,1670,9447,10092,5601,7867,830,26999,1513,5605,7520,1667,1378,3708,2212,940,340061,3659,10747,685,7189,1839,26052,79671,6195,5894,10096,4627,3937,5566,351,8411,4179,6464,7706,2209,10628,57506,54106,5641,1386,3815,1072,113,2931,5441,3326,107,11277,3710,2260,5515,8517,2534,1650,417,55718,3084,7187,9474,6300,10810,57690,7186,567,5338,9252,6714,25,661,79132,3654,9436,117145,5781,5600,2205,2065,1385,6885,10695,22914,3802,5170,2254,10451,7128,5609,5295,5747,2353,7316,8772,733,57761,2268,10000,613211,2220,81622,59307,942,1026,1432,329,5606,6196,5136,1499,7448,919,51517,714,5296,4790,109,81030,5159,5567,718,1604,4690,9140,57162,245915,4772,983,3689,245929,60,5528,27327,7323,729,4205,23239,4064,4775,112,3107,5058,2264,10878,27006,10892,51295,3845,10552,1956,6283,10458,2214,2248,9261,4792,84166,5434,23098,5337,10163,1540,920,2207,3075,114548,2475,1793,5137,8737,2064,3661,11344,4067,713,5154,7409,55845,5518,5300,5336,3551,644414,8503,5627,4791,503618,207,330,51428,2249,7456,54941,4773,929,1846,725,2246,10718,712,23118,6778,3665,2219,9051,1508,27161,79109,4650,24145,284266,2261,1520,10010,5580,3320,414325,646626,122618,8398,6850,55894,6199,29110,3164,5591,5575,84265,246330,10910,9641,111,26281,8817,1515,7322,3265,3428	NLRP1,ACTG1,TSC2,PRKCSH,TMEM189-UBE2V1,NRG2,PRKCA,DEFB136,POLR3K,PRSS2,ELMO2,PIK3CA,DNM2,C4BPA,TLR5,DUSP7,MLST8,LAT,UBA52,PRKAR2B,CD36,PLCG1,WAS,ZFYVE20,ADCY8,LIMK1,CFD,NOD2,KITLG,GSK3B,POLR2H,LZTS1,MEF2C,TRIM56,DEFA1B,LRRFIP1,HMGB1,POLR2K,CARD9,VAV2,DHX9,JUN,MBL2,DEFA5,AIM2,ARPC5,MAPK9,MAPKAPK3,CAPZA2,CYFIP2,CTSK,MAP2K2,XRCC5,DEFA1,CR1,ITPR1,FCGR2A,CD28,TMEM173,IRF1,MASP2,BTC,TRAF6,HBEGF,DNM3,NLRX1,RPS6KA1,RAF1,ACTR3,MYH9,LCP2,PRKACA,APP,EEA1,CD46,SHC1,TRIM25,FCGR1A,TXNIP,MAVS,TLR9,LGMN,ATF2,KIT,CFL1,ADCY7,GSK3A,POLR2L,HSP90AB1,ADCY1,TREX1,ITPR3,FGFR1,PPP2CA,IKBKG,FYN,DDOST,ART1,POLR3E,NRG1,TRAF3,ATG5,MAPK12,WASF3,TNRC6C,TRAF2,B2M,PLD2,RPS6KA5,SRC,ABL1,POLR3D,DHX58,IRAK1,NCR2,THEM4,PTPN11,MAPK11,FCER1A,ERBB3,CREB1,MAP3K7,CNPY3,KLRK1,KIR2DL1,PDPK1,FGF9,VAV3,TNFAIP3,MAP2K7,PIK3R1,PTK2,FOS,UBC,FADD,C8G,TRIB3,FGR,AKT3,DEFB134,FCN2,UNC93B1,SIGIRR,CD86,CDKN1A,MAPK14,BIRC2,MAP2K3,RPS6KA2,PDE1A,CTNNB1,VTN,CD247,NCKIPSD,C1QC,PIK3R2,NFKB1,ADCY3,ZBP1,PDGFRB,PRKACB,C3,CD55,NCK1,ATG12,PELI1,DEFB112,NFATC1,CDK1,ITGB2,DEFB115,ACTB,PPP2R5D,TNRC6A,UBE2D3,C6,MEF2A,PHLPP1,CD180,NFATC3,ADCY6,HLA-C,PAK1,FGFR4,CFHR3,FGF22,MALT1,ECSIT,KRAS,ARPC1A,EGFR,S100A12,BAIAP2,FCGR3A,FGF3,MAPKAPK2,NFKBIA,NLRC5,POLR2E,SARM1,PLD1,WASF2,CYLD,CD4,FCER1G,CFH,NLRP3,MTOR,DOCK1,PDE1C,RIPK1,ERBB2,IRF3,TWF2,LYN,C1QB,PDGFA,VAV1,BRK1,PPP2R1A,PIN1,PLCG2,IKBKB,DEFB131,PIK3R3,PROS1,NFKB2,DEFB104B,AKT1,BIRC3,DDX41,FGF4,WIPF1,RNF125,NFATC2,CD14,DUSP4,C4BPB,FGF1,NRG3,C1QA,TAB2,STAT6,IRF7,FCN1,PSTPIP1,CTSB,AGO2,MAPKAP1,MYO9B,PANX1,SIGLEC15,FGFR3,CTSS,TANK,PRKCD,HSP90AA1,DEFB103A,LOC646626,PLD4,PLA2G6,SYK,DEFB103B,RPS6KB2,TBK1,NR4A1,PRKDC,PRKAR1B,POLR3GL,PELI3,SUGT1,IKBKE,ADCY5,FGF20,FGF18,CTSV,UBE2D2,HRAS,IFI16
REACT_125	Processing of Capped Intron-Containing Pre-mRNA	0.227211632854433	-1.48187339250206	143	68	0.0214985773000316	3163	7167	9939,10978,6635,220988,83443,10992,10914,6632,29894,23225,6427,84844,55746,3191,3192,1977,81929,55749,1477,5441,5725,6628,10921,3185,3183,11100,51585,8021,10907,10421,6426,57794,10262,10236,8243,5437,9128,2521,8086,9785,8106,6627,3178,5440,6431,10250,1660,10949,4799,3187,56339,129401,11097,10189,3184,4904,79902,5438,51639,8175,7175,5439,9688,5434,1478,22916,6625,79869	RBM8A,CLP1,SNRPE,HNRNPA3,SF3B5,SF3B2,PAPOLA,SNRPD1,CPSF1,NUP210,SRSF2,PHF5A,NUP133,HNRNPL,HNRNPU,EIF4E,SEH1L,CCAR1,CSTF1,POLR2L,PTBP1,SNRPB,RNPS1,HNRNPF,HNRNPC,HNRNPUL1,PCF11,NUP214,TXNL4A,CD2BP2,SRSF1,SUGP1,SF3B4,HNRNPR,SMC1A,POLR2H,PRPF4,FUS,AAAS,DHX38,PABPN1,SNRPA1,HNRNPA1,POLR2K,SRSF6,SRRM1,DHX9,HNRNPA0,NFX1,HNRNPH1,METTL3,NUP35,NUPL2,ALYREF,HNRNPD,YBX1,NUP85,POLR2I,SF3B14,SF3A2,TPR,POLR2J,NUP93,POLR2E,CSTF2,NCBP2,SNRNP70,CPSF7
REACT_11184	Botulinum neurotoxicity	0.228982526976677	-1.47410957975089	18	10	0.00316155548529877	3163	7167	2054,9482,6843,6804,127833,112755,8675,8676,10228,6811	STX2,STX8,VAMP1,STX1A,SYT2,STX1B,STX16,STX11,STX6,STX5
REACT_683	G1/S-Specific Transcription	0.228982526976677	-1.47410957975089	18	10	0.00316155548529877	3163	7167	993,5111,81620,7027,6241,990,898,983,7084,26271	CDC25A,PCNA,CDT1,TFDP1,RRM2,CDC6,CCNE1,CDK1,TK2,FBXO5
REACT_23767	cGMP effects	0.228982526976677	-1.47410957975089	18	10	0.00316155548529877	3163	7167	3779,5136,10846,3778,3708,5593,10335,5138,5152,5139	KCNMB1,PDE1A,PDE10A,KCNMA1,ITPR1,PRKG2,MRVI1,PDE2A,PDE9A,PDE3A
REACT_121384	Acyl chain remodelling of PS	0.228982526976677	-1.47410957975089	18	10	0.00316155548529877	3163	7167	283748,5321,255189,254531,81579,154141,10162,8399,100137049,123745	PLA2G4D,PLA2G4A,PLA2G4F,LPCAT4,PLA2G12A,MBOAT1,LPCAT3,PLA2G10,PLA2G4B,PLA2G4E
REACT_164002	Scavenging by Class H Receptors	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	55576,23166,6678	STAB2,STAB1,SPARC
REACT_19376	Regulation of Commissural axon pathfinding by Slit and Robo	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	6092,64221,6091	ROBO2,ROBO3,ROBO1
REACT_16903	Histamine receptors	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	11255,3274,3269	HRH3,HRH2,HRH1
REACT_1484	Transcription from mitochondrial promoters	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	64216,7978,5442	TFB2M,MTERF,POLRMT
REACT_12473	Neurophilin interactions with VEGF and VEGFR	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	8829,8828,2321	NRP1,NRP2,FLT1
REACT_790	Activation of PKB	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	5170,57761,117145	PDPK1,TRIB3,THEM4
REACT_111108	Mitochondrial ABC transporters	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	11194,23456,10058	ABCB8,ABCB10,ABCB6
REACT_12469	Hypusine synthesis from eIF5A-lysine	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	83475,1984,1725	DOHH,EIF5A,DHPS
REACT_11117	Vitamin B1 (thiamin) metabolism	0.229962803308824	-1.46983770788204	4	3	0.00094846664558963	3163	7167	79178,10560,27010	THTPA,SLC19A2,TPK1
REACT_75790	Cytokine Signaling in Immune system	0.231793493173124	-1.46190841933707	291	135	0.0426809990515334	3163	7167	5724,387522,3606,3113,8554,5696,23225,3572,4790,5296,5290,1977,3556,5567,81929,3562,7311,9978,11274,57162,983,5335,1981,64127,2185,6041,8086,3636,1958,2688,8519,129401,11097,1154,8878,10379,2210,3107,79902,2889,3460,3845,1982,29760,5605,4261,7324,3554,9688,10437,7534,10581,3659,7189,3635,5894,8835,3661,4067,5566,5495,2317,7409,1399,8651,6672,6464,7706,55746,2209,5300,3551,8503,103,3557,4791,815,4599,4215,5777,3664,867,54472,8021,7297,3669,9021,8517,817,2534,3839,23118,6500,3665,3082,79155,1326,8672,567,3105,3383,3123,5771,3662,5770,3654,5580,5618,5781,3717,960,6885,6774,6850,3837,818,402569,6868,4502,10410,5295,1973,3570,246330,3454,3560,1437,7316,7175,816,6776,3394,3265,3567,8945	PTAFR,TMEM189-UBE2V1,IL18,HLA-DPA1,PIAS1,PSMB8,NUP210,IL6ST,NFKB1,PIK3R2,PIK3CA,EIF4E,IL1RAP,PRKACB,SEH1L,IL3,UBA52,RBX1,USP18,PELI1,CDK1,PLCG1,EIF4G1,NOD2,PTK2B,RNASEL,AAAS,INPPL1,EGR1,GH1,IFITM1,NUP35,NUPL2,CISH,SQSTM1,IRF9,FCGR1B,HLA-C,NUP85,RAPGEF1,IFNGR2,KRAS,EIF4G2,BLNK,MAP2K2,CIITA,UBE2E1,IL1R1,NUP93,IFI30,YWHAZ,IFITM2,IRF1,TRAF6,INPP5D,RAF1,SOCS2,IRF3,LYN,PRKACA,PPM1B,FLNB,VAV1,CRKL,SOCS1,SP100,SHC1,TRIM25,NUP133,FCGR1A,PIN1,IKBKB,PIK3R3,ADAR,IL1RN,NFKB2,CAMK2A,MX1,MAP3K3,PTPN6,IRF6,CBL,TOLLIP,NUP214,TYK2,ISG20,SOCS3,IKBKG,CAMK2D,FYN,KPNA3,TAB2,SKP1,IRF7,HGF,TNIP2,MAP3K8,EIF4G3,B2M,HLA-A,ICAM1,HLA-DRB1,PTPN2,IRF4,PTPN1,IRAK1,PRKCD,PRLR,PTPN11,JAK2,CD44,MAP3K7,STAT3,SYK,KPNB1,CAMK2G,KPNA7,ADAM17,MT2A,IFITM3,PIK3R1,EIF4A1,IL6R,PELI3,IFNAR1,IL2RB,CSF2,UBC,TPR,CAMK2B,STAT5A,IRF8,HRAS,IL5,BTRC
REACT_11242	Proteolytic cleavage of SNARE complex proteins	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	2054,9482,6843,6804,112755,8675,8676,10228,6811	STX2,STX8,VAMP1,STX1A,STX1B,STX16,STX11,STX6,STX5
REACT_24980	Regulation of IFNG signaling	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	5771,8554,5770,8651,3460,5777,5781,3717,9021	PTPN2,PIAS1,PTPN1,SOCS1,IFNGR2,PTPN6,PTPN11,JAK2,SOCS3
REACT_163977	Regulation of innate immune responses to cytosolic DNA	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	29110,7311,51428,11277,3661,81030,340061,7316,81844	TBK1,UBA52,DDX41,TREX1,IRF3,ZBP1,TMEM173,UBC,TRIM56
REACT_1998	Gap-filling DNA repair synthesis and ligation in GG-NER	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	6118,5111,5983,5426,3978,5981,57804,5424,5425	RPA2,PCNA,RFC3,POLE,LIG1,RFC1,POLD4,POLD1,POLD2
REACT_74	Gap-filling DNA repair synthesis and ligation in TC-NER	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	6118,5111,5983,5426,3978,5981,57804,5424,5425	RPA2,PCNA,RFC3,POLE,LIG1,RFC1,POLD4,POLD1,POLD2
REACT_118632	Trafficking and processing of endosomal TLR	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	81622,1520,1508,1515,54106,5641,11344,1513,10695	UNC93B1,CTSS,CTSB,CTSV,TLR9,LGMN,TWF2,CTSK,CNPY3
REACT_380	Synthesis of very long-chain fatty acyl-CoAs	0.233302948292671	-1.45541746268925	16	9	0.00284539993676889	3163	7167	51703,60481,2180,6785,79071,23305,2181,64834,51144	ACSL5,ELOVL5,ACSL1,ELOVL4,ELOVL6,ACSL6,ACSL3,ELOVL1,HSD17B12
REACT_23916	Signal regulatory protein (SIRP) family interactions	0.237321347816172	-1.43834015828803	14	8	0.00252924438823901	3163	7167	2185,5747,8935,6714,5777,55423,140885,5781	PTK2B,PTK2,SKAP2,SRC,PTPN6,SIRPG,SIRPA,PTPN11
REACT_1439	Common Pathway	0.237321347816172	-1.43834015828803	14	8	0.00252924438823901	3163	7167	2165,2147,2159,2162,5624,5627,462,2153	F13B,F2,F10,F13A1,PROC,PROS1,SERPINC1,F5
REACT_1932	Mitotic Telophase/Cytokinesis	0.237321347816172	-1.43834015828803	14	8	0.00252924438823901	3163	7167	10112,10274,8243,23047,9493,23383,10726,5885	KIF20A,STAG1,SMC1A,PDS5B,KIF23,MAU2,NUDC,RAD21
REACT_25354	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	7189,8517,246330,57162,3654,387522,3551	TRAF6,IKBKG,PELI3,PELI1,IRAK1,TMEM189-UBE2V1,IKBKB
REACT_120919	Synthesis of PE	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	85465,55224,1120,64900,23761,23175,55500	EPT1,ETNK2,CHKB,LPIN3,PISD,LPIN1,ETNK1
REACT_22336	Presynaptic nicotinic acetylcholine receptors	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	8973,1145,1146,1135,1137,1142,1141	CHRNA6,CHRNE,CHRNG,CHRNA2,CHRNA4,CHRNB3,CHRNB2
REACT_22303	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	1139,8973,55584,1135,1137,1142,1141	CHRNA7,CHRNA6,CHRNA9,CHRNA2,CHRNA4,CHRNB3,CHRNB2
REACT_24918	IRAK1 recruits IKK complex	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	7189,8517,246330,57162,3654,387522,3551	TRAF6,IKBKG,PELI3,PELI1,IRAK1,TMEM189-UBE2V1,IKBKB
REACT_13606	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	784,774,27092,777,10369,773,9254	CACNB3,CACNA1B,CACNG4,CACNA1E,CACNG2,CACNA1A,CACNA2D2
REACT_163910	NOTCH2 intracellular domain regulates transcription	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	388585,3280,4853,3516,1385,9794,10046	HES5,HES1,NOTCH2,RBPJ,CREB1,MAML1,MAMLD1
REACT_23826	Passive Transport by Aquaporins	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	89872,363,360,366,364,343,358	AQP10,AQP6,AQP3,AQP9,AQP7,AQP8,AQP1
REACT_1023	Pyrimidine catabolism	0.240791527799091	-1.42382374972502	12	7	0.00221308883970914	3163	7167	30833,1890,51251,56953,7378,1807,4907	NT5C,TYMP,NT5C3A,NT5M,UPP1,DPYS,NT5E
REACT_1849	mRNA 3'-end processing	0.240933996644317	-1.42323225584666	35	18	0.00569079987353778	3163	7167	6431,10250,9939,10921,10978,4799,51585,6426,10914,29894,6427,10189,1478,22916,8106,79869,9785,1477	SRSF6,SRRM1,RBM8A,RNPS1,CLP1,NFX1,PCF11,SRSF1,PAPOLA,CPSF1,SRSF2,ALYREF,CSTF2,NCBP2,PABPN1,CPSF7,DHX38,CSTF1
REACT_1665	Glucagon signaling in metabolic regulation	0.240933996644317	-1.42323225584666	35	18	0.00569079987353778	3163	7167	2788,5575,107,2786,2782,5577,5566,2783,548645,2642,111,59345,114,112,109,51764,5567,113	GNG7,PRKAR1B,ADCY1,GNG4,GNB1,PRKAR2B,PRKACA,GNB2,DNAJC25,GCGR,ADCY5,GNB4,ADCY8,ADCY6,ADCY3,GNG13,PRKACB,ADCY7
REACT_118811	IRF3 mediated activation of type 1 IFN	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	3661,29110,81030,340061	IRF3,TBK1,ZBP1,TMEM173
REACT_25091	ER Quality Control Compartment (ERQC)	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	55757,9695,11253,80267	UGGT2,EDEM1,MAN1B1,EDEM3
REACT_13450	Vitamins	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	56603,1591,1592,120227	CYP26B1,CYP24A1,CYP26A1,CYP2R1
REACT_150209	Synthesis of 5-eicosatetraenoic acids	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	240,4056,2876,2879	ALOX5,LTC4S,GPX1,GPX4
REACT_163813	Scavenging by Class F Receptors	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	811,10808,3320,8578	CALR,HSPH1,HSP90AA1,SCARF1
REACT_150237	Phosphate bond hydrolysis by NUDT proteins	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	4521,131870,79873,55270	NUDT1,NUDT16,NUDT18,NUDT15
REACT_150320	Synthesis of Lipoxins (LX)	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	3248,240,22949,4056	HPGD,ALOX5,PTGR1,LTC4S
REACT_13695	p75NTR negatively regulates cell cycle via SC1	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	4804,3066,8841,11108	NGFR,HDAC2,HDAC3,PRDM4
REACT_7964	Lectin pathway of complement activation	0.241023088299601	-1.42286254800717	6	4	0.00126462219411951	3163	7167	4153,2219,10747,2220	MBL2,FCN1,MASP2,FCN2
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.242645944842598	-1.41615191523183	50	25	0.00790388871324692	3163	7167	7189,1540,7128,22861,330,114548,64170,3326,387522,1432,329,351,24145,8517,10910,9447,3654,23118,3551,10628,64127,5600,6885,9051,6300	TRAF6,CYLD,TNFAIP3,NLRP1,BIRC3,NLRP3,CARD9,HSP90AB1,TMEM189-UBE2V1,MAPK14,BIRC2,APP,PANX1,IKBKG,SUGT1,AIM2,IRAK1,TAB2,IKBKB,TXNIP,NOD2,MAPK11,MAP3K7,PSTPIP1,MAPK12
REACT_21326	Activation of the AP-1 family of transcription factors	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	3725,5600,1432,1386,2353,5601	JUN,MAPK11,MAPK14,ATF2,FOS,MAPK9
REACT_12529	Signaling by VEGF	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	5228,8829,7422,2324,8828,2321	PGF,NRP1,VEGFA,FLT4,NRP2,FLT1
REACT_13443	Regulated proteolysis of p75NTR	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	7189,6868,4804,51107,4790,5664	TRAF6,ADAM17,NGFR,APH1A,NFKB1,PSEN2
REACT_19342	Inactivation of Cdc42 and Rac	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	23380,2817,9901,80728,57522,6091	SRGAP2,GPC1,SRGAP3,ARHGAP39,SRGAP1,ROBO1
REACT_12380	VEGF ligand-receptor interactions	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	5228,8829,7422,2324,8828,2321	PGF,NRP1,VEGFA,FLT4,NRP2,FLT1
REACT_115574	Alpha-defensins	0.243277807504073	-1.41355124788616	10	6	0.00189693329117926	3163	7167	728358,1667,920,1670,5645,417	DEFA1B,DEFA1,CD4,DEFA5,PRSS2,ART1
REACT_115654	Degradation of cysteine and homocysteine	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	51380,58472,6821,1468,1491	CSAD,SQRDL,SUOX,SLC25A10,CTH
REACT_12447	Negative regulation of the PI3K/AKT network	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	57761,23239,207,10000,117145	TRIB3,PHLPP1,AKT1,AKT3,THEM4
REACT_1432	TNF signaling	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	8737,6868,7186,8772,7132	RIPK1,ADAM17,TRAF2,FADD,TNFRSF1A
REACT_11218	Coenzyme A biosynthesis	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	8034,55229,79646,53354,60490	SLC25A16,PANK4,PANK3,PANK1,PPCDC
REACT_19375	Regulation of Insulin Secretion by Free Fatty Acids	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	5330,2769,2767,9630,5331	PLCB2,GNA15,GNA11,GNA14,PLCB3
REACT_20580	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	29780,87,5829,7016,6251	PARVB,ACTN1,PXN,TESK1,RSU1
REACT_13583	Neurotransmitter Clearance In The Synaptic Cleft	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	6582,4128,1312,43,6531	SLC22A2,MAOA,COMT,ACHE,SLC6A3
REACT_19193	Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1)	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	5330,2769,2767,9630,5331	PLCB2,GNA15,GNA11,GNA14,PLCB3
REACT_97	Recruitment of repair and signaling proteins to double-strand breaks	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	472,672,9656,7158,10111	ATM,BRCA1,MDC1,TP53BP1,RAD50
REACT_121100	Linoleic acid (LA) metabolism	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	9415,215,60481,2180,3995	FADS2,ABCD1,ELOVL5,ACSL1,FADS3
REACT_19357	Multifunctional anion exchangers	0.24394792180469	-1.41080051169616	8	5	0.00158077774264938	3163	7167	10861,115019,1836,1951,65010	SLC26A1,SLC26A9,SLC26A2,CELSR3,SLC26A6
REACT_19187	Clathrin derived vesicle budding	0.245319800320743	-1.40519261217894	63	31	0.00980082200442618	3163	7167	3482,9698,6643,63915,9026,8905,3312,10717,7163,375,9685,51429,7164,8729,55330,5286,7037,4074,10053,653653,8773,8907,1785,84062,408,1211,2580,130340,8775,5878,23557	IGF2R,PUM1,SNX2,BLOC1S5,HIP1R,AP1S2,HSPA8,AP4B1,TPD52,ARF1,CLINT1,SNX9,TPD52L1,GBF1,BLOC1S4,PIK3C2A,TFRC,M6PR,AP1M2,LOC653653,SNAP23,AP1M1,DNM2,DTNBP1,ARRB1,CLTA,GAK,AP1S3,NAPA,RAB5C,SNAPIN
REACT_11235	trans-Golgi Network Vesicle Budding	0.245319800320743	-1.40519261217894	63	31	0.00980082200442618	3163	7167	3482,9698,6643,63915,9026,8905,3312,10717,7163,375,9685,51429,7164,8729,55330,5286,7037,4074,10053,653653,8773,8907,1785,84062,408,1211,2580,130340,8775,5878,23557	IGF2R,PUM1,SNX2,BLOC1S5,HIP1R,AP1S2,HSPA8,AP4B1,TPD52,ARF1,CLINT1,SNX9,TPD52L1,GBF1,BLOC1S4,PIK3C2A,TFRC,M6PR,AP1M2,LOC653653,SNAP23,AP1M1,DNM2,DTNBP1,ARRB1,CLTA,GAK,AP1S3,NAPA,RAB5C,SNAPIN
REACT_1275	Mitotic Anaphase	0.245828592682255	-1.4031207636266	179	84	0.0265570660765096	3163	7167	5684,5721,83540,11004,64682,5687,5696,25909,4001,5518,55746,5701,10393,10213,23047,8379,51434,81929,7112,23141,1058,7311,632,991,6232,701,8697,79682,5515,3796,5529,7514,8881,122706,5525,79980,25936,5709,5714,7444,8243,151648,7443,5528,51433,5689,6396,22919,1063,11243,54908,9491,4000,91687,55920,2010,699,79019,79902,5686,10726,11130,1060,5692,10274,9184,5905,5710,5685,7316,7324,5704,221496,5699,996,113130,147841,80152,54820,10197,11065,3619,29945,5885	PSMA3,PSME2,NUF2,KIF2C,ANAPC1,PSMA6,PSMB8,AHCTF1,LMNB1,PPP2R1A,NUP133,PSMC2,ANAPC10,PSMD14,PDS5B,MAD1L1,ANAPC7,SEH1L,TMPO,ANKLE2,CENPA,UBA52,BGLAP,CDC20,RPS27,BUB1B,CDC23,CENPU,PPP2CA,KIF2A,PPP2R5E,XPO1,CDC16,PSMB11,PPP2R5A,DSN1,NSL1,PSMD3,PSMD8,VRK2,SMC1A,SGOL1,VRK1,PPP2R5D,ANAPC5,PSMB1,SEC13,MAPRE1,CENPF,PMF1,SPDL1,PSMF1,LMNA,CENPL,RCC2,EMD,BUB1,CENPM,NUP85,PSMA5,NUDC,ZWINT,CENPC,PSMB4,STAG1,BUB3,RANGAP1,PSMD4,PSMA4,UBC,UBE2E1,PSMC4,LEMD2,PSMB10,CDC27,CDCA5,SPC24,CENPT,NDE1,PSME3,UBE2C,INCENP,ANAPC4,RAD21
REACT_19351	Signaling by Robo receptor	0.247268391897665	-1.39728092541096	33	17	0.0053746443250079	3163	7167	5058,27,25,56924,23380,6092,10487,4690,5216,80728,57522,6091,55740,10298,2817,64221,9901	PAK1,ABL2,ABL1,PAK6,SRGAP2,ROBO2,CAP1,NCK1,PFN1,ARHGAP39,SRGAP1,ROBO1,ENAH,PAK4,GPC1,ROBO3,SRGAP3
REACT_15370	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.251105031855001	-1.38188397377207	144	68	0.0214985773000316	3163	7167	84254,6195,5894,3763,2782,5578,5566,3766,2783,5331,161,6196,1739,2899,109,1146,5567,10369,815,113,1139,27092,2036,2788,107,8973,548645,2554,817,3762,3765,114,59345,83988,80852,346562,1145,55584,2774,1141,2566,88,2570,2890,1142,2793,112,51764,1385,5330,2771,818,2567,5170,3768,5923,6237,3759,9568,2902,2786,1135,2900,1137,111,160,816,3265	CAMKK1,RPS6KA1,RAF1,KCNJ6,GNB1,PRKCA,PRKACA,KCNJ10,GNB2,PLCB3,AP2A2,RPS6KA2,DLG1,GRIK3,ADCY3,CHRNG,PRKACB,CACNG2,CAMK2A,ADCY7,CHRNA7,CACNG4,EPB41L1,GNG7,ADCY1,CHRNA6,DNAJC25,GABRA1,CAMK2D,KCNJ5,KCNJ9,ADCY8,GNB4,NCALD,GRIP2,GNAT3,CHRNE,CHRNA9,GNAL,CHRNB2,GABRG2,ACTN2,GABRR2,GRIA1,CHRNB3,GNGT2,ADCY6,GNG13,CREB1,PLCB2,GNAI2,CAMK2G,GABRG3,PDPK1,KCNJ12,RASGRF1,RRAS,KCNJ2,GABBR2,GRIN1,GNG4,CHRNA2,GRIK4,CHRNA4,ADCY5,AP2A1,CAMK2B,HRAS
REACT_6344	Tat-mediated HIV elongation arrest and recovery	0.253883905722185	-1.37087818053511	31	16	0.00505848877647803	3163	7167	9150,5438,6923,5441,5440,6924,6921,7469,8178,6827,5439,904,1025,5434,5437,25920	CTDP1,POLR2I,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,CCNT1,CDK9,POLR2E,POLR2H,NELFB
REACT_16969	Striated Muscle Contraction	0.253883905722185	-1.37087818053511	31	16	0.00505848877647803	3163	7167	7140,7134,7136,7125,7170,7169,7171,7431,88,7135,4607,4621,8557,7139,7168,4634	TNNT3,TNNC1,TNNI2,TNNC2,TPM3,TPM2,TPM4,VIM,ACTN2,TNNI1,MYBPC3,MYH3,TCAP,TNNT2,TPM1,MYL3
REACT_6143	Pausing and recovery of Tat-mediated HIV elongation	0.253883905722185	-1.37087818053511	31	16	0.00505848877647803	3163	7167	9150,5438,6923,5441,5440,6924,6921,7469,8178,6827,5439,904,1025,5434,5437,25920	CTDP1,POLR2I,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,CCNT1,CDK9,POLR2E,POLR2H,NELFB
REACT_121248	HS-GAG biosynthesis	0.253883905722185	-1.37087818053511	31	16	0.00505848877647803	3163	7167	375790,8509,3339,9957,6385,9672,2131,64711,6382,3340,9394,9951,9953,2817,9955,266722	AGRN,NDST2,HSPG2,HS3ST1,SDC4,SDC3,EXT1,HS3ST6,SDC1,NDST1,HS6ST1,HS3ST4,HS3ST3B1,GPC1,HS3ST3A1,HS6ST3
REACT_318	Platelet degranulation	0.255125563044344	-1.36599945091936	85	41	0.0129623774897249	3163	7167	2335,7094,6403,22927,88,2621,7042,2153,351,5154,10487,27154,5216,6678,928,5627,5345,7414,1072,7277,6647,7044,10257,9948,3309,641455,2162,813,87,2316,7422,948,5265,1675,226,81,7450,5054,3082,1191,5660	FN1,TLN1,SELP,HABP4,ACTN2,GAS6,TGFB2,F5,APP,PDGFA,CAP1,BRPF3,PFN1,SPARC,CD9,PROS1,SERPINF2,VCL,CFL1,TUBA4A,SOD1,LEFTY2,ABCC4,WDR1,HSPA5,POTEM,F13A1,CALU,ACTN1,FLNA,VEGFA,CD36,SERPINA1,CFD,ALDOA,ACTN4,VWF,SERPINE1,HGF,CLU,PSAP
REACT_118773	Signaling by the B Cell Receptor (BCR)	0.255193608823791	-1.36573277161903	217	101	0.0319317104015175	3163	7167	23291,685,1839,5684,7249,942,2475,5721,2064,9542,1026,4067,30011,7409,5154,5696,5687,6464,4790,3551,5336,5296,5701,5290,10213,8503,3815,5159,64223,7311,2931,207,4690,2249,868,3710,867,2260,2246,8517,5335,2534,10718,122706,5714,5709,4254,6500,2932,3084,6725,27327,5689,57690,4794,27161,79109,23239,9491,640,973,2261,117145,5781,27071,84876,2065,1385,6885,646626,6850,5686,6199,2264,5170,2254,5692,3164,27006,5295,974,10892,3845,5710,29760,5685,1956,7316,2248,5704,5699,57761,10000,26281,4792,8817,3708,10197,3265,940,8945	FBXW11,BTC,HBEGF,PSMA3,TSC2,CD86,MTOR,PSME2,ERBB2,NRG2,CDKN1A,LYN,SH3KBP1,VAV1,PDGFA,PSMB8,PSMA6,SHC1,NFKB1,IKBKB,PLCG2,PIK3R2,PSMC2,PIK3CA,PSMD14,PIK3R3,KIT,PDGFRB,MLST8,UBA52,GSK3A,AKT1,NCK1,FGF4,CBLB,ITPR3,CBL,FGFR1,FGF1,IKBKG,PLCG1,FYN,NRG3,PSMB11,PSMD8,PSMD3,KITLG,SKP1,GSK3B,NRG1,SRMS,TNRC6A,PSMB1,TNRC6C,NFKBIE,AGO2,MAPKAP1,PHLPP1,PSMF1,BLK,CD79A,FGFR3,THEM4,PTPN11,DAPP1,ORAI1,ERBB3,CREB1,MAP3K7,LOC646626,SYK,PSMA5,RPS6KB2,FGFR4,PDPK1,FGF9,PSMB4,NR4A1,FGF22,PIK3R1,CD79B,MALT1,KRAS,PSMD4,BLNK,PSMA4,EGFR,UBC,FGF3,PSMC4,PSMB10,TRIB3,AKT3,FGF20,NFKBIA,FGF18,ITPR1,PSME3,HRAS,CD28,BTRC
REACT_19331	Cell-cell junction organization	0.257678477882599	-1.35604268098301	59	29	0.00916851090736642	3163	7167	1002,81607,7122,84552,3728,9080,1495,253559,64398,50848,9074,1016,23562,1006,84612,1007,1013,999,1499,1003,1012,5818,1364,1365,1000,9071,1366,56288,149461	CDH4,PVRL4,CLDN5,PARD6G,JUP,CLDN9,CTNNA1,CADM2,MPP5,F11R,CLDN6,CDH18,CLDN14,CDH8,PARD6B,CDH9,CDH15,CDH1,CTNNB1,CDH5,CDH13,PVRL1,CLDN4,CLDN3,CDH2,CLDN10,CLDN7,PARD3,CLDN19
REACT_17029	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.260806070501169	-1.343978172739	29	15	0.00474233322794815	3163	7167	22948,10576,5204,7280,7278,10383,4157,7203,60,10574,84617,5201,10381,10376,7277	CCT5,CCT2,PFDN5,TUBB2A,TUBA3C,TUBB4B,MC1R,CCT3,ACTB,CCT7,TUBB6,PFDN1,TUBB3,TUBA1B,TUBA4A
REACT_19195	Adherens junctions interactions	0.260806070501169	-1.343978172739	29	15	0.00474233322794815	3163	7167	1002,1007,81607,1013,3728,1499,999,1495,1003,1012,5818,253559,1016,1000,1006	CDH4,CDH9,PVRL4,CDH15,JUP,CTNNB1,CDH1,CTNNA1,CDH5,CDH13,PVRL1,CADM2,CDH18,CDH2,CDH8
REACT_1383	Glycolysis	0.260806070501169	-1.343978172739	29	15	0.00474233322794815	3163	7167	5210,5515,2597,5518,5211,5230,5208,5313,226,5209,5224,2821,5315,2023,5528	PFKFB4,PPP2CA,GAPDH,PPP2R1A,PFKL,PGK1,PFKFB2,PKLR,ALDOA,PFKFB3,PGAM2,GPI,PKM,ENO1,PPP2R5D
REACT_12560	Basigin interactions	0.260806070501169	-1.343978172739	29	15	0.00474233322794815	3163	7167	3675,3655,11136,8140,3688,9123,682,56301,857,4099,481,3897,23428,9057,23539	ITGA3,ITGA6,SLC7A9,SLC7A5,ITGB1,SLC16A3,BSG,SLC7A10,CAV1,MAG,ATP1B1,L1CAM,SLC7A8,SLC7A6,SLC16A8
REACT_6837	Regulation of APC/C activators between G1/S and early anaphase	0.267072287040779	-1.32023591924435	81	39	0.0123300663926652	3163	7167	5689,51433,5684,5721,891,9491,26271,64682,5687,5696,5701,51343,10393,10213,51434,5686,7311,5692,9184,991,701,8697,5710,5685,983,7316,7324,5704,5699,8881,122706,996,5709,5714,6500,10197,11065,29945,8945	PSMB1,ANAPC5,PSMA3,PSME2,CCNB1,PSMF1,FBXO5,ANAPC1,PSMA6,PSMB8,PSMC2,FZR1,ANAPC10,PSMD14,ANAPC7,PSMA5,UBA52,PSMB4,BUB3,CDC20,BUB1B,CDC23,PSMD4,PSMA4,CDK1,UBC,UBE2E1,PSMC4,PSMB10,CDC16,PSMB11,CDC27,PSMD3,PSMD8,SKP1,PSME3,UBE2C,ANAPC4,BTRC
REACT_150312	Synthesis of IP3 and IP4 in the cytosol	0.268064654100192	-1.31652708092406	27	14	0.00442617767941827	3163	7167	3707,5335,3636,9651,89869,5333,3635,5336,5332,113026,122618,5330,8867,5331	ITPKB,PLCG1,INPPL1,PLCH2,PLCZ1,PLCD1,INPP5D,PLCG2,PLCB4,PLCD3,PLD4,PLCB2,SYNJ1,PLCB3
REACT_120815	Regulation of Hypoxia-inducible Factor (HIF) by Oxygen	0.268064654100192	-1.31652708092406	27	14	0.00442617767941827	3163	7167	7323,7311,6923,112398,2034,3091,9978,8453,7322,6921,7422,405,7316,54583	UBE2D3,UBA52,TCEB2,EGLN2,EPAS1,HIF1A,RBX1,CUL2,UBE2D2,TCEB1,VEGFA,ARNT,UBC,EGLN1
REACT_111214	G0 and Early G1	0.268064654100192	-1.31652708092406	27	14	0.00442617767941827	3163	7167	132660,286826,9134,993,5111,1859,5933,7027,4605,990,7029,983,898,55957	LIN54,LIN9,CCNE2,CDC25A,PCNA,DYRK1A,RBL1,TFDP1,MYBL2,CDC6,TFDP2,CDK1,CCNE1,LIN37
REACT_121311	Cellular response to hypoxia	0.268064654100192	-1.31652708092406	27	14	0.00442617767941827	3163	7167	7323,7311,6923,112398,2034,3091,9978,8453,7322,6921,7422,405,7316,54583	UBE2D3,UBA52,TCEB2,EGLN2,EPAS1,HIF1A,RBX1,CUL2,UBE2D2,TCEB1,VEGFA,ARNT,UBC,EGLN1
REACT_163906	ECM proteoglycans	0.270985168395263	-1.3056911887689	55	27	0.00853619981030667	3163	7167	1299,3915,375790,7143,7148,7042,63827,284217,1605,2331,3909,4146,7448,6678,1462,3688,176,3913,5054,63923,633,3685,3687,3694,1311,1298,3911	COL9A3,LAMC1,AGRN,TNR,TNXB,TGFB2,BCAN,LAMA1,DAG1,FMOD,LAMA3,MATN1,VTN,SPARC,VCAN,ITGB1,ACAN,LAMB2,SERPINE1,TNN,BGN,ITGAV,ITGAX,ITGB6,COMP,COL9A2,LAMA5
REACT_118659	RORA Activates Circadian Expression	0.275694740763976	-1.28846103707203	25	13	0.0041100221308884	3163	7167	80205,85441,79718,8841,6256,406,6720,6907,96764,9572,6095,10499,10498	CHD9,HELZ2,TBL1XR1,HDAC3,RXRA,ARNTL,SREBF1,TBL1X,TGS1,NR1D1,RORA,NCOA2,CARM1
REACT_115639	Sulfur amino acid metabolism	0.275694740763976	-1.28846103707203	25	13	0.0041100221308884	3163	7167	27430,58478,55256,58472,6821,1468,875,51380,2805,191,55748,4548,1491	MAT2B,ENOPH1,ADI1,SQRDL,SUOX,SLC25A10,CBS,CSAD,GOT1,AHCY,CNDP2,MTR,CTH
REACT_13552	Integrin cell surface interactions	0.276433674150385	-1.28578436328518	66	32	0.0101169775529561	3163	7167	1299,2335,1284,375790,3339,3655,80781,682,50848,3383,3675,999,3696,7448,22801,3672,960,3687,8515,3694,1311,1298,91522,1605,83700,3689,2200,1305,3688,3681,3685,1307	COL9A3,FN1,COL4A2,AGRN,HSPG2,ITGA6,COL18A1,BSG,F11R,ICAM1,ITGA3,CDH1,ITGB8,VTN,ITGA11,ITGA1,CD44,ITGAX,ITGA10,ITGB6,COMP,COL9A2,COL23A1,DAG1,JAM3,ITGB2,FBN1,COL13A1,ITGB1,ITGAD,ITGAV,COL16A1
REACT_1768	Processing of Capped Intronless Pre-mRNA	0.283738198091421	-1.25970330368088	23	12	0.00379386658235852	3163	7167	29894,134353,6628,10978,1478,22916,6635,51585,79869,8106,10914,1477	CPSF1,LSM11,SNRPB,CLP1,CSTF2,NCBP2,SNRPE,PCF11,CPSF7,PABPN1,PAPOLA,CSTF1
REACT_115854	GRB2 events in ERBB2 signaling	0.283738198091421	-1.25970330368088	23	12	0.00379386658235852	3163	7167	685,1839,10718,5894,9542,2064,3084,3845,5605,3265,983,1956	BTC,HBEGF,NRG3,RAF1,NRG2,ERBB2,NRG1,KRAS,MAP2K2,HRAS,CDK1,EGFR
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK	0.28485417471178	-1.25577789733803	214	99	0.0312993993044578	3163	7167	5724,1839,29933,2769,2840,6195,552,5894,6375,4923,1606,2782,8527,57105,9002,5578,1241,2783,351,23566,5331,431704,3814,56923,6196,57121,2642,8620,5296,5290,8503,8111,846,148,2147,10287,2788,3710,548645,983,9630,1907,59345,9162,5032,9170,2869,8525,1908,3358,1609,7204,2520,1128,7200,23620,5028,64106,5997,5583,147,65012,6846,2793,5580,51764,1385,623,5330,1131,5029,84432,347148,5295,1906,2786,10316,3845,5605,2767,1956,553,747,64407,6865,221955,183,57113,10161,3708,5332,594857,7201,94233,3265,3269,6870,2847,5731	PTAFR,HBEGF,GPR132,GNA15,GPR17,RPS6KA1,AVPR1A,RAF1,XCL1,NTSR1,DGKA,GNB1,DGKD,CYSLTR2,F2RL3,PRKCA,LTB4R,GNB2,APP,LPAR3,PLCB3,RGS21,KISS1,NMUR2,RPS6KA2,LPAR5,GCGR,NPFF,PIK3R2,PIK3CA,PIK3R3,GPR68,CASR,ADRA1A,F2,RGS19,GNG7,ITPR3,DNAJC25,CDK1,GNA14,EDN2,GNB4,DGKI,P2RY11,LPAR2,GRK5,DGKZ,EDN3,HTR2C,DGKQ,TRIO,GAST,CHRM1,TRH,NTSR2,P2RY1,NPFFR1,RGS2,PRKCH,ADRA1B,SLC26A10,XCL2,GNGT2,PRKCD,GNG13,CREB1,BDKRB1,PLCB2,CHRM3,P2RY2,PROK1,QRFP,PIK3R1,EDN1,GNG4,NMUR1,KRAS,MAP2K2,GNA11,EGFR,AVPR1B,DAGLA,RGS18,TACR2,DAGLB,AGT,TRPC7,LPAR6,ITPR1,PLCB4,NPS,TRHR,OPN4,HRAS,HRH1,TACR3,MCHR1,PTGER1
REACT_1826	Nucleotide Excision Repair	0.285371357521249	-1.25396393804631	51	25	0.00790388871324692	3163	7167	1643,2967,2067,5438,5983,902,5441,5440,56949,3978,2072,5424,6118,5111,5439,5426,2968,7507,5887,5434,5437,5981,57804,5425,1642	DDB2,GTF2H3,ERCC1,POLR2I,RFC3,CCNH,POLR2L,POLR2K,XAB2,LIG1,ERCC4,POLD1,RPA2,PCNA,POLR2J,POLE,GTF2H4,XPA,RAD23B,POLR2E,POLR2H,RFC1,POLD4,POLD2,DDB1
REACT_147867	Translocation of GLUT4 to the Plasma Membrane	0.290447080876785	-1.23633388494086	62	30	0.0094846664558963	3163	7167	5563,51552,5564,207,5872,23216,5565,4012,10971,23265,7531,8766,57644,10890,53632,5898,4218,79058,51422,57148,8773,5867,4621,149371,11127,22920,55770,7534,9882,2810	PRKAA2,RAB14,PRKAB1,AKT1,RAB13,TBC1D1,PRKAB2,LNPEP,YWHAQ,EXOC7,YWHAE,RAB11A,MYH7B,RAB10,PRKAG3,RALA,RAB8A,ASPSCR1,PRKAG2,RALGAPB,SNAP23,RAB4A,MYH3,EXOC8,KIF3A,KIFAP3,EXOC2,YWHAZ,TBC1D4,SFN
REACT_13819	Regulation of gene expression in beta cells	0.292245713674586	-1.23016034537708	21	11	0.00347771103382864	3163	7167	3170,2645,3651,207,5313,3174,10000,389692,723961,3172,3630	FOXA2,GCK,PDX1,AKT1,PKLR,HNF4G,AKT3,MAFA,INS-IGF2,HNF4A,INS
REACT_118563	RIP-mediated NFkB activation via ZBP1	0.292245713674586	-1.23016034537708	21	11	0.00347771103382864	3163	7167	3146,8517,4792,4790,3551,1660,8737,81030,4791,351,6283	HMGB1,IKBKG,NFKBIA,NFKB1,IKBKB,DHX9,RIPK1,ZBP1,NFKB2,APP,S100A12
REACT_120752	HS-GAG degradation	0.292245713674586	-1.23016034537708	21	11	0.00347771103382864	3163	7167	3423,6448,375790,10855,3339,4669,6385,9672,6382,2817,3425	IDS,SGSH,AGRN,HPSE,HSPG2,NAGLU,SDC4,SDC3,SDC1,GPC1,IDUA
REACT_116005	SHC1 events in ERBB4 signaling	0.292245713674586	-1.23016034537708	21	11	0.00347771103382864	3163	7167	685,1839,10718,6464,5894,9542,3084,3845,5605,3265,983	BTC,HBEGF,NRG3,SHC1,RAF1,NRG2,NRG1,KRAS,MAP2K2,HRAS,CDK1
REACT_6781	APC/C:Cdc20 mediated degradation of mitotic proteins	0.293325716044853	-1.22647162854408	73	35	0.0110654441985457	3163	7167	5689,51433,5684,5721,891,9491,64682,5687,5696,5701,10393,10213,51434,5686,7311,5692,9184,991,701,8697,5710,5685,983,7316,7324,5704,5699,8881,122706,996,5714,5709,10197,11065,29945	PSMB1,ANAPC5,PSMA3,PSME2,CCNB1,PSMF1,ANAPC1,PSMA6,PSMB8,PSMC2,ANAPC10,PSMD14,ANAPC7,PSMA5,UBA52,PSMB4,BUB3,CDC20,BUB1B,CDC23,PSMD4,PSMA4,CDK1,UBC,UBE2E1,PSMC4,PSMB10,CDC16,PSMB11,CDC27,PSMD8,PSMD3,PSME3,UBE2C,ANAPC4
REACT_20524	Signal amplification	0.300994005875428	-1.20066492846667	34	17	0.0053746443250079	3163	7167	5321,2769,2788,2786,2782,5028,1432,6714,2783,548645,2767,9630,2793,59345,346562,51764,2771	PLA2G4A,GNA15,GNG7,GNG4,GNB1,P2RY1,MAPK14,SRC,GNB2,DNAJC25,GNA11,GNA14,GNGT2,GNB4,GNAT3,GNG13,GNAI2
REACT_471	E2F mediated regulation of DNA replication	0.300994005875428	-1.20066492846667	34	17	0.0053746443250079	3163	7167	993,4999,28227,5558,81620,6241,990,891,983,898,7084,26271,5515,5111,5518,7027,84515	CDC25A,ORC2,PPP2R3B,PRIM2,CDT1,RRM2,CDC6,CCNB1,CDK1,CCNE1,TK2,FBXO5,PPP2CA,PCNA,PPP2R1A,TFDP1,MCM8
REACT_1893	Resolution of Abasic Sites (AP sites)	0.301279698609498	-1.19971621444057	19	10	0.00316155548529877	3163	7167	5111,4913,3978,4350,3980,57804,5424,4595,5425,8930	PCNA,NTHL1,LIG1,MPG,LIG3,POLD4,POLD1,MUTYH,POLD2,MBD4
REACT_20506	Na+/Cl- dependent neurotransmitter transporters	0.301279698609498	-1.19971621444057	19	10	0.00316155548529877	3163	7167	6534,6582,6533,348932,9152,6531,6538,55117,340024,6571	SLC6A7,SLC22A2,SLC6A6,SLC6A18,SLC6A5,SLC6A3,SLC6A11,SLC6A15,SLC6A19,SLC18A2
REACT_22387	Synthesis of substrates in N-glycan biosythesis	0.301279698609498	-1.19971621444057	19	10	0.00316155548529877	3163	7167	79947,5372,9945,6675,57171,79644,29925,54344,5373,29926	DHDDS,PMM1,GFPT2,UAP1,DOLPP1,SRD5A3,GMPPB,DPM3,PMM2,GMPPA
REACT_9509	Gap junction assembly	0.301279698609498	-1.19971621444057	19	10	0.00316155548529877	3163	7167	2700,57165,219770,2703,2707,127534,2709,84694,125111,2702	GJA3,GJC2,GJD4,GJA8,GJB3,GJB4,GJB5,GJA10,GJD3,GJA5
REACT_1104	Base Excision Repair	0.301279698609498	-1.19971621444057	19	10	0.00316155548529877	3163	7167	5111,4913,3978,4350,3980,57804,5424,4595,5425,8930	PCNA,NTHL1,LIG1,MPG,LIG3,POLD4,POLD1,MUTYH,POLD2,MBD4
REACT_24023	Regulation of Water Balance by Renal Aquaporins	0.309342135866943	-1.17330737880251	45	22	0.00695542206765729	3163	7167	4645,2788,5575,358,107,2786,2782,5577,360,5566,8766,2783,548645,2793,111,59345,114,112,109,51764,5567,113	MYO5B,GNG7,PRKAR1B,AQP1,ADCY1,GNG4,GNB1,PRKAR2B,AQP3,PRKACA,RAB11A,GNB2,DNAJC25,GNGT2,ADCY5,GNB4,ADCY8,ADCY6,ADCY3,GNG13,PRKACB,ADCY7
REACT_828	G2/M Checkpoints	0.309342135866943	-1.17330737880251	45	22	0.00695542206765729	3163	7167	993,55388,4999,5983,63967,10926,1111,990,9088,891,4171,995,983,3364,6118,4173,7465,4174,84515,472,545,4172	CDC25A,MCM10,ORC2,RFC3,CLSPN,DBF4,CHEK1,CDC6,PKMYT1,CCNB1,MCM2,CDC25C,CDK1,HUS1,RPA2,MCM4,WEE1,MCM5,MCM8,ATM,ATR,MCM3
REACT_6244	Pausing and recovery of HIV elongation	0.310009578905424	-1.17115208228542	32	16	0.00505848877647803	3163	7167	9150,5438,6923,5441,5440,6924,6921,7469,8178,6827,5439,904,1025,5434,5437,25920	CTDP1,POLR2I,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,CCNT1,CDK9,POLR2E,POLR2H,NELFB
REACT_6259	HIV elongation arrest and recovery	0.310009578905424	-1.17115208228542	32	16	0.00505848877647803	3163	7167	9150,5438,6923,5441,5440,6924,6921,7469,8178,6827,5439,904,1025,5434,5437,25920	CTDP1,POLR2I,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,CCNT1,CDK9,POLR2E,POLR2H,NELFB
REACT_25042	Destabilization of mRNA by KSRP	0.310918557413645	-1.16822427436572	17	9	0.00284539993676889	3163	7167	207,56915,8570,7534,5600,54512,5073,1432,167227	AKT1,EXOSC5,KHSRP,YWHAZ,MAPK11,EXOSC4,PARN,MAPK14,DCP2
REACT_1128	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.310918557413645	-1.16822427436572	17	9	0.00284539993676889	3163	7167	5111,4913,3978,4350,57804,5424,4595,5425,8930	PCNA,NTHL1,LIG1,MPG,POLD4,POLD1,MUTYH,POLD2,MBD4
REACT_13537	p75NTR signals via NF-kB	0.310918557413645	-1.16822427436572	17	9	0.00284539993676889	3163	7167	7189,7311,3654,8878,4792,4790,3551,4804,7316	TRAF6,UBA52,IRAK1,SQSTM1,NFKBIA,NFKB1,IKBKB,NGFR,UBC
REACT_2192	Removal of DNA patch containing abasic residue	0.310918557413645	-1.16822427436572	17	9	0.00284539993676889	3163	7167	5111,4913,3978,4350,57804,5424,4595,5425,8930	PCNA,NTHL1,LIG1,MPG,POLD4,POLD1,MUTYH,POLD2,MBD4
REACT_238	Amino acid synthesis and interconversion (transamination)	0.310918557413645	-1.16822427436572	17	9	0.00284539993676889	3163	7167	84706,2805,883,440,2875,29968,4942,2752,5723	GPT2,GOT1,CCBL1,ASNS,GPT,PSAT1,OAT,GLUL,PSPH
REACT_13	Metabolism of amino acids and derivatives	0.311941954880358	-1.16493815053076	193	89	0.028137843819159	3163	7167	384,6723,5684,58472,1728,6528,1735,131669,5721,56922,51380,51686,445,7173,2639,4942,2752,10841,55256,5696,440,5687,6821,8564,548596,5701,10213,2805,1610,26275,1491,113451,2954,189,6303,56267,4967,4953,1743,9380,122706,8942,5714,5709,15,5723,84706,5689,4329,2593,435,875,6538,9491,27430,8659,6534,1159,883,389434,54498,1468,51582,191,501,1152,64087,1644,5686,58478,5625,6470,5692,29968,594,130013,262,5710,4548,5685,5704,5699,2875,23498,5092,55748,10197,125061,11112	ARG2,SRM,PSMA3,SQRDL,NQO1,SLC5A5,DIO3,UROC1,PSME2,MCCC1,CSAD,OAZ3,ASS1,TPO,GCDH,OAT,GLUL,FTCD,ADI1,PSMB8,ASNS,PSMA6,SUOX,KMO,CKMT1A,PSMC2,PSMD14,GOT1,DAO,HIBCH,CTH,ADC,GSTZ1,AGXT,SAT1,CCBL2,OGDH,ODC1,DLST,GRHPR,PSMB11,KYNU,PSMD8,PSMD3,AANAT,PSPH,GPT2,PSMB1,ALDH6A1,GAMT,ASL,CBS,SLC6A11,PSMF1,MAT2B,ALDH4A1,SLC6A7,CKMT1B,CCBL1,IYD,SMOX,SLC25A10,AZIN1,AHCY,ALDH7A1,CKB,MCCC2,DDC,PSMA5,ENOPH1,PRODH,SHMT1,PSMB4,PSAT1,BCKDHB,ACMSD,AMD1,PSMD4,MTR,PSMA4,PSMC4,PSMB10,GPT,HAAO,PCBD1,CNDP2,PSME3,AFMID,HIBADH
REACT_27161	Transcriptional Regulation of White Adipocyte Differentiation	0.315933721877268	-1.15222282828864	78	37	0.0116977552956054	3163	7167	9612,6256,400569,55090,85441,84246,9441,4790,896,5105,6720,3952,9443,55588,90390,10499,1052,10498,9439,80205,79718,1019,8841,10025,948,51129,1959,9969,1051,1879,9314,51586,9440,688,6907,7026,96764	NCOR2,RXRA,MED11,MED9,HELZ2,MED10,MED26,NFKB1,CCND3,PCK1,SREBF1,LEP,MED7,MED29,MED30,NCOA2,CEBPD,CARM1,MED23,CHD9,TBL1XR1,CDK4,HDAC3,MED16,CD36,ANGPTL4,EGR2,MED13,CEBPB,EBF1,KLF4,MED15,MED17,KLF5,TBL1X,NR2F2,TGS1
REACT_160255	Nuclear Envelope Breakdown	0.318076163482088	-1.14546441707407	43	21	0.00663926651912741	3163	7167	140609,891,8021,983,4000,129401,221496,11097,7175,23225,4001,2010,10783,55746,7444,9688,7443,79902,81929,8086,7112	NEK7,CCNB1,NUP214,CDK1,LMNA,NUP35,LEMD2,NUPL2,TPR,NUP210,LMNB1,EMD,NEK6,NUP133,VRK2,NUP93,VRK1,NUP85,SEH1L,AAAS,TMPO
REACT_121061	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.318076163482088	-1.14546441707407	43	21	0.00663926651912741	3163	7167	7323,9612,7050,7311,142,4092,4221,7316,6497,4088,4087,5933,904,4609,1025,7027,3726,5054,7029,4089,6667	UBE2D3,NCOR2,TGIF1,UBA52,PARP1,SMAD7,MEN1,UBC,SKI,SMAD3,SMAD2,RBL1,CCNT1,MYC,CDK9,TFDP1,JUNB,SERPINE1,TFDP2,SMAD4,SP1
REACT_27283	Interleukin-2 signaling	0.318076163482088	-1.14546441707407	43	21	0.00663926651912741	3163	7167	3562,3636,5777,5894,3635,5295,3845,3560,1437,983,5605,6464,5296,5290,2185,8503,6776,3717,6850,3265,3567	IL3,INPPL1,PTPN6,RAF1,INPP5D,PIK3R1,KRAS,IL2RB,CSF2,CDK1,MAP2K2,SHC1,PIK3R2,PIK3CA,PTK2B,PIK3R3,STAT5A,JAK2,SYK,HRAS,IL5
REACT_18339	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline	0.319549816091043	-1.14084209841084	30	15	0.00474233322794815	3163	7167	152,111,2793,59345,2788,9254,112,2782,2786,51764,784,2771,548645,2783,150	ADRA2C,ADCY5,GNGT2,GNB4,GNG7,CACNA2D2,ADCY6,GNB1,GNG4,GNG13,CACNB3,GNAI2,DNAJC25,GNB2,ADRA2A
REACT_118568	Pre-NOTCH Transcription and Translation	0.319549816091043	-1.14084209841084	30	15	0.00474233322794815	3163	7167	595,3725,4851,57690,2648,8850,7027,10046,27161,1871,4853,3516,9794,7029,27327	CCND1,JUN,NOTCH1,TNRC6C,KAT2A,KAT2B,TFDP1,MAMLD1,AGO2,E2F3,NOTCH2,RBPJ,MAML1,TFDP2,TNRC6A
REACT_18352	Eicosanoid ligand-binding receptors	0.321263205156048	-1.1354945380734	15	8	0.00252924438823901	3163	7167	57105,11251,5732,1241,165140,2840,5739,5731	CYSLTR2,PTGDR2,PTGER2,LTB4R,OXER1,GPR17,PTGIR,PTGER1
REACT_378	Repair synthesis of patch ~27-30 bases long  by DNA polymerase	0.321263205156048	-1.1354945380734	15	8	0.00252924438823901	3163	7167	6118,5111,5983,5426,5981,57804,5424,5425	RPA2,PCNA,RFC3,POLE,RFC1,POLD4,POLD1,POLD2
REACT_661	SHC-mediated signalling	0.321263205156048	-1.1354945380734	15	8	0.00252924438823901	3163	7167	3845,6464,53358,983,3265,5894,5605,25759	KRAS,SHC1,SHC3,CDK1,HRAS,RAF1,MAP2K2,SHC2
REACT_1993	Repair synthesis for gap-filling by DNA polymerase in TC-NER	0.321263205156048	-1.1354945380734	15	8	0.00252924438823901	3163	7167	6118,5111,5983,5426,5981,57804,5424,5425	RPA2,PCNA,RFC3,POLE,RFC1,POLD4,POLD1,POLD2
REACT_19397	Transport of inorganic cations/anions and amino acids/oligopeptides	0.328461101065291	-1.11333686187323	96	45	0.0142269996838445	3163	7167	10723,1951,6528,10861,6522,6574,80024,6549,9057,57835,6509,83697,1468,6521,6548,55117,56301,1836,57468,6558,6512,6559,348932,142680,9498,81539,206358,65010,115019,26503,6533,283652,160728,6575,11136,6550,8140,6508,9497,6569,340024,10991,124935,23428,121260	SLC12A7,CELSR3,SLC5A5,SLC26A1,SLC4A2,SLC20A1,SLC8B1,SLC9A2,SLC7A6,SLC4A5,SLC1A4,SLC4A9,SLC25A10,SLC4A1,SLC9A1,SLC6A15,SLC7A10,SLC26A2,SLC12A5,SLC12A2,SLC1A7,SLC12A3,SLC6A18,SLC34A3,SLC4A8,SLC38A1,SLC36A1,SLC26A6,SLC26A9,SLC17A5,SLC6A6,SLC24A5,SLC5A8,SLC20A2,SLC7A9,SLC9A3,SLC7A5,SLC4A3,SLC4A7,SLC34A1,SLC6A19,SLC38A3,SLC43A2,SLC7A8,SLC15A4
REACT_9411	Gap junction trafficking	0.329680621158095	-1.10963090782906	28	14	0.00442617767941827	3163	7167	2700,57165,1601,219770,1785,2703,1211,2707,127534,1212,2709,84694,125111,2702	GJA3,GJC2,DAB2,GJD4,DNM2,GJA8,CLTA,GJB3,GJB4,CLTB,GJB5,GJA10,GJD3,GJA5
REACT_12484	EGFR downregulation	0.329680621158095	-1.10963090782906	28	14	0.00442617767941827	3163	7167	161,9146,7311,10254,8874,160,58513,29924,1211,867,10253,1956,30011,7316	AP2A2,HGS,UBA52,STAM2,ARHGEF7,AP2A1,EPS15L1,EPN1,CLTA,CBL,SPRY2,EGFR,SH3KBP1,UBC
REACT_16936	Prefoldin mediated transfer of substrate  to CCT/TriC	0.329680621158095	-1.10963090782906	28	14	0.00442617767941827	3163	7167	22948,10576,5204,7280,7278,10383,4157,7203,60,10574,84617,5201,10381,7277	CCT5,CCT2,PFDN5,TUBB2A,TUBA3C,TUBB4B,MC1R,CCT3,ACTB,CCT7,TUBB6,PFDN1,TUBB3,TUBA4A
REACT_15525	Nuclear Receptor transcription pathway	0.33048641525534	-1.10718972414988	52	25	0.00790388871324692	3163	7167	6097,6258,5914,2649,2908,29982,3174,2104,3164,7067,9971,6256,2494,6095,7101,7421,2103,2516,9970,4929,2101,9572,4306,3172,126382	RORC,RXRG,RARA,NR6A1,NR3C1,NRBF2,HNF4G,ESRRG,NR4A1,THRA,NR1H4,RXRA,NR5A2,RORA,NR2E1,VDR,ESRRB,NR5A1,NR1I3,NR4A2,ESRRA,NR1D1,NR3C2,HNF4A,NR2C2AP
REACT_6954	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.331165477547676	-1.10513709636132	74	35	0.0110654441985457	3163	7167	5689,51433,5684,5721,891,9491,64682,5687,5696,5701,10393,10213,51434,5686,7311,5692,9184,991,701,8697,5710,5685,983,7316,7324,5704,5699,8881,122706,996,5714,5709,10197,11065,29945	PSMB1,ANAPC5,PSMA3,PSME2,CCNB1,PSMF1,ANAPC1,PSMA6,PSMB8,PSMC2,ANAPC10,PSMD14,ANAPC7,PSMA5,UBA52,PSMB4,BUB3,CDC20,BUB1B,CDC23,PSMD4,PSMA4,CDK1,UBC,UBE2E1,PSMC4,PSMB10,CDC16,PSMB11,CDC27,PSMD8,PSMD3,PSME3,UBE2C,ANAPC4
REACT_18334	NCAM signaling for neurite out-growth	0.331471881387727	-1.10421229531364	63	30	0.0094846664558963	3163	7167	1299,1292,1284,375790,5894,8912,3845,5747,9252,4902,983,6710,6714,5605,57731,2260,1293,2534,1291,64096,51332,2668,6900,779,784,1385,3265,8911,1298,2675	COL9A3,COL6A2,COL4A2,AGRN,RAF1,CACNA1H,KRAS,PTK2,RPS6KA5,NRTN,CDK1,SPTB,SRC,MAP2K2,SPTBN4,FGFR1,COL6A3,FYN,COL6A1,GFRA4,SPTBN5,GDNF,CNTN2,CACNA1S,CACNB3,CREB1,HRAS,CACNA1I,COL9A2,GFRA2
REACT_163773	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	3146,3665,4791,351,4790,6283,1660	HMGB1,IRF7,NFKB2,APP,NFKB1,S100A12,DHX9
REACT_22345	Organic cation/anion/zwitterion transport	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	6582,6581,6583,5002,85413,9356,6584	SLC22A2,SLC22A3,SLC22A4,SLC22A18,SLC22A16,SLC22A6,SLC22A5
REACT_121284	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	9415,215,60481,3295,2180,30,3995	FADS2,ABCD1,ELOVL5,HSD17B4,ACSL1,ACAA1,FADS3
REACT_14835	Notch-HLH transcription pathway	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	4851,4853,3516,9794,2648,8850,10046	NOTCH1,NOTCH2,RBPJ,MAML1,KAT2A,KAT2B,MAMLD1
REACT_121147	alpha-linolenic acid (ALA) metabolism	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	9415,215,60481,3295,2180,30,3995	FADS2,ABCD1,ELOVL5,HSD17B4,ACSL1,ACAA1,FADS3
REACT_75808	The NLRP3 inflammasome	0.332447473534103	-1.10127340569901	13	7	0.00221308883970914	3163	7167	10910,114548,351,3326,10628,9051,24145	SUGT1,NLRP3,APP,HSP90AB1,TXNIP,PSTPIP1,PANX1
REACT_160123	Fcgamma receptor (FCGR) dependent phagocytosis	0.333386432728777	-1.09845300316839	105	49	0.015491621877964	3163	7167	10163,10810,71,1793,10096,7410,4627,5338,4650,4067,6714,25,7409,55845,63916,2209,10092,919,5336,5296,5580,51517,5290,3320,122618,8398,6850,1072,5058,10451,4690,3326,5295,7456,5747,26999,3710,10552,10458,2214,5335,2268,2534,7454,3984,3708,2212,60,5337	WASF2,WASF3,ACTG1,DOCK1,ACTR3,VAV2,MYH9,PLD2,MYO9B,LYN,SRC,ABL1,VAV1,BRK1,ELMO2,FCGR1A,ARPC5,CD247,PLCG2,PIK3R2,PRKCD,NCKIPSD,PIK3CA,HSP90AA1,PLD4,PLA2G6,SYK,CFL1,PAK1,VAV3,NCK1,HSP90AB1,PIK3R1,WIPF1,PTK2,CYFIP2,ITPR3,ARPC1A,BAIAP2,FCGR3A,PLCG1,FGR,FYN,WAS,LIMK1,ITPR1,FCGR2A,ACTB,PLD1
REACT_19323	Sphingolipid metabolism	0.339158449404896	-1.08128787842583	72	34	0.0107492886500158	3163	7167	1455,151742,2581,6609,91012,8612,64781,2629,8877,285362,79642,9517,153642,4758,130367,410,2531,129807,8611,340075,204219,8560,166929,9218,123099,5660,5007,79603,55627,10715,411,56848,2760,29956	CSNK1G2,PPM1L,GALC,SMPD1,CERS5,PPAP2C,CERK,GBA,SPHK1,SUMF1,ARSJ,SPTLC2,ARSK,NEU1,SGPP2,ARSA,KDSR,NEU4,PPAP2A,ARSI,CERS3,DEGS1,SGMS2,VAPA,DEGS2,PSAP,OSBP,CERS4,SMPD4,CERS1,ARSB,SPHK2,GM2A,CERS2
REACT_17004	Chaperonin-mediated protein folding	0.33951652847311	-1.08023264841702	50	24	0.00758773316471704	3163	7167	10576,7280,10383,26272,8877,7203,63971,84617,26270,26985,5201,10376,22948,26234,5204,11328,7278,4157,60,55294,10574,54461,10381,7277	CCT2,TUBB2A,TUBB4B,FBXO4,SPHK1,CCT3,KIF13A,TUBB6,FBXO6,AP3M1,PFDN1,TUBA1B,CCT5,FBXL5,PFDN5,FKBP9,TUBA3C,MC1R,ACTB,FBXW7,CCT7,FBXW5,TUBB3,TUBA4A
REACT_121399	MHC class II antigen presentation	0.340428616872427	-1.07754981744858	103	48	0.0151754663294341	3163	7167	1781,6396,3797,10120,26052,8722,1508,9493,285643,11004,84516,375,821,26153,3123,3113,161,10053,1520,653653,51164,8907,1785,147700,22920,3835,5641,1509,130340,1512,10802,83547,10112,7879,8905,1510,1513,972,114876,51128,22872,3796,1778,160,1515,11127,10437,1211	DYNC1I2,SEC13,KIF3C,ACTR1B,DNM3,CTSF,CTSB,KIF23,KIF4B,KIF2C,DCTN5,ARF1,CANX,KIF26A,HLA-DRB1,HLA-DPA1,AP2A2,AP1M2,CTSS,LOC653653,DCTN4,AP1M1,DNM2,KLC3,KIFAP3,KIF22,LGMN,CTSD,AP1S3,CTSH,SEC24A,RILP,KIF20A,RAB7A,AP1S2,CTSE,CTSK,CD74,OSBPL1A,SAR1B,SEC31A,KIF2A,DYNC1H1,AP2A1,CTSV,KIF3A,IFI30,CLTA
REACT_150425	Resolution of Sister Chromatid Cohesion	0.340428616872427	-1.07754981744858	103	48	0.0151754663294341	3163	7167	6396,22919,1063,83540,11004,11243,891,54908,91687,55920,25909,5518,55746,23047,8379,699,79019,79902,81929,10726,11130,1058,1060,9184,10274,632,991,5905,701,6232,983,79682,3796,5515,5529,7514,5525,79980,25936,113130,8243,147841,80152,54820,151648,3619,5528,5885	SEC13,MAPRE1,CENPF,NUF2,KIF2C,PMF1,CCNB1,SPDL1,CENPL,RCC2,AHCTF1,PPP2R1A,NUP133,PDS5B,MAD1L1,BUB1,CENPM,NUP85,SEH1L,NUDC,ZWINT,CENPA,CENPC,BUB3,STAG1,BGLAP,CDC20,RANGAP1,BUB1B,RPS27,CDK1,CENPU,KIF2A,PPP2CA,PPP2R5E,XPO1,PPP2R5A,DSN1,NSL1,CDCA5,SMC1A,SPC24,CENPT,NDE1,SGOL1,INCENP,PPP2R5D,RAD21
REACT_1036	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.340482432666647	-1.07739174747933	26	13	0.0041100221308884	3163	7167	2976,661,5441,9328,6908,5440,55718,5434,84265,5437,2972,11178,51728	GTF3C2,POLR3D,POLR2L,GTF3C5,TBP,POLR2K,POLR3E,POLR2E,POLR3GL,POLR2H,BRF1,LZTS1,POLR3K
REACT_1853	Post-translational modification: synthesis of GPI-anchored proteins	0.340482432666647	-1.07739174747933	26	13	0.0041100221308884	3163	7167	5279,93183,51604,9091,5329,54872,8733,80031,54344,5277,94005,5281,55650	PIGC,PIGM,PIGT,PIGQ,PLAUR,PIGG,GPAA1,SEMA6D,DPM3,PIGA,PIGS,PIGF,PIGV
REACT_12472	Regulatory RNA pathways	0.340482432666647	-1.07739174747933	26	13	0.0041100221308884	3163	7167	57690,5438,5439,5441,54487,5440,23405,27161,5434,6895,5437,8575,27327	TNRC6C,POLR2I,POLR2J,POLR2L,DGCR8,POLR2K,DICER1,AGO2,POLR2E,TARBP2,POLR2H,PRKRA,TNRC6A
REACT_8027	Processive synthesis on the C-strand of the telomere	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	3978,6118,5111,5424,57804,5425	LIG1,RPA2,PCNA,POLD1,POLD4,POLD2
REACT_118862	Signaling by NOTCH3	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	3714,54567,182,28514,51107,5664	JAG2,DLL4,JAG1,DLL1,APH1A,PSEN2
REACT_18265	Regulation of the Fanconi anemia pathway	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	472,545,7398,7311,27033,7316	ATM,ATR,USP1,UBA52,ZBTB32,UBC
REACT_18423	Activation of Chaperone Genes by ATF6-alpha	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	811,22926,4800,468,1649,3309	CALR,ATF6,NFYA,ATF4,DDIT3,HSPA5
REACT_15510	Recruitment of NuMA to mitotic centrosomes	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	4926,891,983,10426,85378,114791	NUMA1,CCNB1,CDK1,TUBGCP3,TUBGCP6,TUBGCP5
REACT_25299	DSCAM interactions	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	5058,5600,9423,1432,1630,6300	PAK1,MAPK11,NTN1,MAPK14,DCC,MAPK12
REACT_111168	Endosomal/Vacuolar pathway	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	567,3107,1520,1515,3105,4012	B2M,HLA-C,CTSS,CTSV,HLA-A,LNPEP
REACT_118636	Signaling by NOTCH4	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	3714,54567,182,28514,51107,5664	JAG2,DLL4,JAG1,DLL1,APH1A,PSEN2
REACT_813	Creatine metabolism	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	6534,6538,1152,1159,548596,2593	SLC6A7,SLC6A11,CKB,CKMT1B,CKMT1A,GAMT
REACT_150266	Establishment of Sister Chromatid Cohesion	0.344655685500475	-1.06520937333949	11	6	0.00189693329117926	3163	7167	114799,10274,113130,8243,23047,5885	ESCO1,STAG1,CDCA5,SMC1A,PDS5B,RAD21
REACT_111119	Antigen processing-Cross presentation	0.345433362183518	-1.06295552794126	81	38	0.0120139108441353	3163	7167	5689,9902,5684,23480,5721,4012,6890,567,4688,9491,3105,811,5696,5687,1520,2209,5701,10213,2210,3107,5686,55176,7311,4689,5692,5710,948,5685,7316,5704,5699,122706,29927,5709,5714,1515,3685,10197	PSMB1,MRC2,PSMA3,SEC61G,PSME2,LNPEP,TAP1,B2M,NCF2,PSMF1,HLA-A,CALR,PSMB8,PSMA6,CTSS,FCGR1A,PSMC2,PSMD14,FCGR1B,HLA-C,PSMA5,SEC61A2,UBA52,NCF4,PSMB4,PSMD4,CD36,PSMA4,UBC,PSMC4,PSMB10,PSMB11,SEC61A1,PSMD3,PSMD8,CTSV,ITGAV,PSME3
REACT_1280	Response to elevated platelet cytosolic Ca2+	0.350651858590886	-1.04796140359722	90	42	0.0132785330382548	3163	7167	2335,7094,6403,22927,88,2621,7042,5578,2153,351,5154,10487,27154,5216,6678,928,5627,5345,7414,1072,7277,6647,7044,10257,9948,3309,641455,2162,813,87,2316,7422,948,5265,1675,226,81,7450,5054,3082,1191,5660	FN1,TLN1,SELP,HABP4,ACTN2,GAS6,TGFB2,PRKCA,F5,APP,PDGFA,CAP1,BRPF3,PFN1,SPARC,CD9,PROS1,SERPINF2,VCL,CFL1,TUBA4A,SOD1,LEFTY2,ABCC4,WDR1,HSPA5,POTEM,F13A1,CALU,ACTN1,FLNA,VEGFA,CD36,SERPINA1,CFD,ALDOA,ACTN4,VWF,SERPINE1,HGF,CLU,PSAP
REACT_75795	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.352054982494524	-1.0439679153135	24	12	0.00379386658235852	3163	7167	51128,10802,22872,811,6396,3309,6890,51752,567,3107,821,3105	SAR1B,SEC24A,SEC31A,CALR,SEC13,HSPA5,TAP1,ERAP1,B2M,HLA-C,CANX,HLA-A
REACT_23862	Nitric oxide stimulates guanylate cyclase	0.352054982494524	-1.0439679153135	24	12	0.00379386658235852	3163	7167	3779,5136,2983,10846,3778,3708,5593,10335,5138,4843,5152,5139	KCNMB1,PDE1A,GUCY1B3,PDE10A,KCNMA1,ITPR1,PRKG2,MRVI1,PDE2A,NOS2,PDE9A,PDE3A
REACT_118789	Circadian Repression of Expression by REV-ERBA	0.352054982494524	-1.0439679153135	24	12	0.00379386658235852	3163	7167	80205,85441,79718,8841,6256,406,6907,96764,9572,6095,10499,10498	CHD9,HELZ2,TBL1XR1,HDAC3,RXRA,ARNTL,TBL1X,TGS1,NR1D1,RORA,NCOA2,CARM1
REACT_25300	Ion channel transport	0.352503025841493	-1.04269607281916	159	73	0.023079355042681	3163	7167	538,7226,7809,5894,1831,284525,1193,6337,1188,56302,1185,6338,2741,477,1182,7311,492,79054,50636,480,259232,481,57198,1184,51761,2554,476,162514,6339,54822,55129,10079,2743,489,2566,495,2570,338440,80727,55107,23120,9311,266675,40,5205,6446,11059,57101,53373,496,65268,2567,219931,196527,59341,491,6262,94015,53828,55515,148229,23250,7316,374868,285242,486,80036,57113,7442,441509,29850,493,478	ATP7A,TRPM2,BSND,RAF1,TSC22D3,SLC9C2,CLIC2,SCNN1A,CLCNKB,TRPV5,CLCN6,SCNN1B,GLRA1,ATP1A2,CLCN3,UBA52,ATP2B3,TRPM8,ANO7,ATP1A4,NALCN,ATP1B1,ATP8B2,CLCN5,ATP8A2,GABRA1,ATP1A1,TRPV3,SCNN1D,TRPM7,ANO10,ATP9A,GLRB,ATP2A3,GABRG2,ATP4A,GABRR2,ANO9,TTYH3,ANO1,ATP10B,ASIC3,BEST4,ASIC2,ATP8B1,SGK1,WWP1,ANO2,TPCN1,ATP4B,WNK2,GABRG3,TPCN2,ANO6,TRPV4,ATP2B2,RYR2,TTYH2,FXYD4,ASIC4,ATP8B3,ATP11A,UBC,ATP9B,HTR3E,FXYD2,TRPM3,TRPC7,TRPV1,GLRA4,TRPM5,ATP2B4,ATP1A3
REACT_162	Elevation of cytosolic Ca2+ levels	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	84876,5023,3710,3708,57113	ORAI1,P2RX1,ITPR3,ITPR1,TRPC7
REACT_16927	Adrenoceptors	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	152,147,154,148,150	ADRA2C,ADRA1B,ADRB2,ADRA1A,ADRA2A
REACT_12442	AKT phosphorylates targets in the nucleus	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	1385,207,3164,10000,6199	CREB1,AKT1,NR4A1,AKT3,RPS6KB2
REACT_19230	Role of Abl in Robo-Slit signaling	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	27,25,10487,2817,6091	ABL2,ABL1,CAP1,GPC1,ROBO1
REACT_121096	EGFR Transactivation by Gastrin	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	3845,1839,5578,3265,1956	KRAS,HBEGF,PRKCA,HRAS,EGFR
REACT_11203	ER to Golgi Transport	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	51128,10802,22872,6396,10113	SAR1B,SEC24A,SEC31A,SEC13,PREB
REACT_22352	Highly calcium permeable nicotinic acetylcholine receptors	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	8973,1135,1137,1142,1141	CHRNA6,CHRNA2,CHRNA4,CHRNB3,CHRNB2
REACT_12507	COPII (Coat Protein 2) Mediated Vesicle Transport	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	51128,10802,22872,6396,10113	SAR1B,SEC24A,SEC31A,SEC13,PREB
REACT_11166	Nef Mediated CD4 Down-regulation	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	161,920,375,51606,160	AP2A2,CD4,ARF1,ATP6V1H,AP2A1
REACT_17050	Folding of actin by CCT/TriC	0.358154544810939	-1.02679069631647	9	5	0.00158077774264938	3163	7167	22948,7203,10576,60,10574	CCT5,CCT3,CCT2,ACTB,CCT7
REACT_169118	Signaling by Leptin	0.364524190324621	-1.00916236396154	22	11	0.00347771103382864	3163	7167	5894,5781,3717,3952,3845,6776,6774,5605,3265,983,9021	RAF1,PTPN11,JAK2,LEP,KRAS,STAT5A,STAT3,MAP2K2,HRAS,CDK1,SOCS3
REACT_1857	Cyclin A/B1 associated events during G2/M transition	0.364524190324621	-1.00916236396154	22	11	0.00347771103382864	3163	7167	5515,993,7465,7514,902,5518,994,9088,891,995,983	PPP2CA,CDC25A,WEE1,XPO1,CCNH,PPP2R1A,CDC25B,PKMYT1,CCNB1,CDC25C,CDK1
REACT_18283	G alpha (q) signalling events	0.365514565852979	-1.00644914873143	193	88	0.0278216882706291	3163	7167	5724,29933,2769,2840,552,6375,4923,1606,2782,8527,57105,9002,1241,2783,351,23566,5331,431704,3814,56923,57121,2642,8620,5296,5290,8503,8111,846,148,2147,10287,2788,3710,548645,9630,1907,59345,9162,5032,2869,9170,8525,1908,3358,1609,7204,2520,1128,7200,23620,5028,64106,5997,5583,147,65012,6846,2793,5580,51764,623,5330,1131,5029,84432,347148,5295,1906,2786,10316,2767,553,747,64407,6865,221955,183,57113,10161,3708,5332,594857,7201,94233,3269,6870,5731,2847	PTAFR,GPR132,GNA15,GPR17,AVPR1A,XCL1,NTSR1,DGKA,GNB1,DGKD,CYSLTR2,F2RL3,LTB4R,GNB2,APP,LPAR3,PLCB3,RGS21,KISS1,NMUR2,LPAR5,GCGR,NPFF,PIK3R2,PIK3CA,PIK3R3,GPR68,CASR,ADRA1A,F2,RGS19,GNG7,ITPR3,DNAJC25,GNA14,EDN2,GNB4,DGKI,P2RY11,GRK5,LPAR2,DGKZ,EDN3,HTR2C,DGKQ,TRIO,GAST,CHRM1,TRH,NTSR2,P2RY1,NPFFR1,RGS2,PRKCH,ADRA1B,SLC26A10,XCL2,GNGT2,PRKCD,GNG13,BDKRB1,PLCB2,CHRM3,P2RY2,PROK1,QRFP,PIK3R1,EDN1,GNG4,NMUR1,GNA11,AVPR1B,DAGLA,RGS18,TACR2,DAGLB,AGT,TRPC7,LPAR6,ITPR1,PLCB4,NPS,TRHR,OPN4,HRH1,TACR3,PTGER1,MCHR1
REACT_25325	Destabilization of mRNA by AUF1 (hnRNP D0)	0.36741271698958	-1.00126949332823	55	26	0.00822004426177679	3163	7167	5689,7311,5684,5692,5721,3312,5710,5685,9491,7316,3304,5704,1981,5699,5687,122706,5696,5714,5709,5701,10213,3184,10197,3315,26986,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,HSPA8,PSMD4,PSMA4,PSMF1,UBC,HSPA1B,PSMC4,EIF4G1,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,HNRNPD,PSME3,HSPB1,PABPC1,PSMA5
REACT_894	RNA Polymerase II Transcription Termination	0.369147742093588	-0.996558329996853	44	21	0.00663926651912741	3163	7167	134353,6628,6431,10250,9939,10921,10978,4799,6635,51585,6426,10914,29894,6427,10189,1478,22916,79869,8106,9785,1477	LSM11,SNRPB,SRSF6,SRRM1,RBM8A,RNPS1,CLP1,NFX1,SNRPE,PCF11,SRSF1,PAPOLA,CPSF1,SRSF2,ALYREF,CSTF2,NCBP2,CPSF7,PABPN1,DHX38,CSTF1
REACT_387	Cleavage of Growing Transcript in the Termination Region	0.369147742093588	-0.996558329996853	44	21	0.00663926651912741	3163	7167	134353,6628,6431,10250,9939,10921,10978,4799,6635,51585,6426,10914,29894,6427,10189,1478,22916,79869,8106,9785,1477	LSM11,SNRPB,SRSF6,SRRM1,RBM8A,RNPS1,CLP1,NFX1,SNRPE,PCF11,SRSF1,PAPOLA,CPSF1,SRSF2,ALYREF,CSTF2,NCBP2,CPSF7,PABPN1,DHX38,CSTF1
REACT_118560	Small Interfering RNA (siRNA) Biogenesis	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	8575,23405,27161,6895	PRKRA,DICER1,AGO2,TARBP2
REACT_11047	Mineralocorticoid biosynthesis	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	1584,1589,1585,3972	CYP11B1,CYP21A2,CYP11B2,LHB
REACT_614	RAF phosphorylates MEK	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	3845,3265,5894,5605	KRAS,HRAS,RAF1,MAP2K2
REACT_1206	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	9153,222962,55315,9154	SLC28A2,SLC29A4,SLC29A3,SLC28A1
REACT_20582	Zinc efflux and compartmentalization by the SLC30 family	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	169026,7779,64924,7780	SLC30A8,SLC30A1,SLC30A5,SLC30A2
REACT_111174	Cross-presentation of particulate exogenous antigens (phagosomes)	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	4689,3685,948,4688	NCF4,ITGAV,CD36,NCF2
REACT_1830	Attachment of GPI anchor to uPAR	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	8733,51604,5329,94005	GPAA1,PIGT,PLAUR,PIGS
REACT_19315	Cation-coupled Chloride cotransporters	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	10723,6559,6558,57468	SLC12A7,SLC12A3,SLC12A2,SLC12A5
REACT_160122	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	891,10783,140609,983	CCNB1,NEK6,NEK7,CDK1
REACT_17062	Beta-oxidation of very long chain fatty acids	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	215,3295,30,1384	ABCD1,HSD17B4,ACAA1,CRAT
REACT_962	MEK activation	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	3845,3265,5894,5605	KRAS,HRAS,RAF1,MAP2K2
REACT_22223	Highly sodium permeable acetylcholine nicotinic receptors	0.373356787601532	-0.985220781401772	7	4	0.00126462219411951	3163	7167	1145,1146,1137,1141	CHRNE,CHRNG,CHRNA4,CHRNB2
REACT_172761	Ca2+ pathway	0.373963673162849	-0.983596616865703	64	30	0.0094846664558963	3163	7167	57690,6929,2788,27161,2786,51701,2782,6932,7481,3710,5578,4772,2783,548645,6934,8323,5331,1499,2793,59345,5145,3708,5593,51764,5158,6885,7855,5330,815,27327	TNRC6C,TCF3,GNG7,AGO2,GNG4,NLK,GNB1,TCF7,WNT11,ITPR3,PRKCA,NFATC1,GNB2,DNAJC25,TCF7L2,FZD6,PLCB3,CTNNB1,GNGT2,GNB4,PDE6A,ITPR1,PRKG2,GNG13,PDE6B,MAP3K7,FZD5,PLCB2,CAMK2A,TNRC6A
REACT_6785	Autodegradation of Cdh1 by Cdh1:APC/C	0.373963673162849	-0.983596616865703	64	30	0.0094846664558963	3163	7167	5689,51433,7311,5684,5692,5721,5710,8697,9491,5685,7324,7316,5704,64682,5699,5687,5696,8881,996,5709,5714,5701,51343,10393,10213,51434,10197,11065,5686,29945	PSMB1,ANAPC5,UBA52,PSMA3,PSMB4,PSME2,PSMD4,CDC23,PSMF1,PSMA4,UBE2E1,UBC,PSMC4,ANAPC1,PSMB10,PSMA6,PSMB8,CDC16,CDC27,PSMD3,PSMD8,PSMC2,FZR1,ANAPC10,PSMD14,ANAPC7,PSME3,UBE2C,PSMA5,ANAPC4
REACT_2071	Pyruvate metabolism	0.378052457601177	-0.972722316268457	20	10	0.00316155548529877	3163	7167	5160,5164,25874,9123,3939,682,55066,51660,23539,3945	PDHA1,PDK2,MPC2,SLC16A3,LDHA,BSG,PDPR,MPC1,SLC16A8,LDHB
REACT_163942	Syndecan interactions	0.378052457601177	-0.972722316268457	20	10	0.00316155548529877	3163	7167	7448,3655,6385,3688,9672,87,3685,5578,3691,6382	VTN,ITGA6,SDC4,ITGB1,SDC3,ACTN1,ITGAV,PRKCA,ITGB4,SDC1
REACT_25148	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.378052457601177	-0.972722316268457	20	10	0.00316155548529877	3163	7167	29110,7311,9641,5781,23098,3665,7187,929,3661,7316	TBK1,UBA52,IKBKE,PTPN11,SARM1,IRF7,TRAF3,CD14,IRF3,UBC
REACT_160189	Stimuli-sensing channels	0.378451463418488	-0.971667448360376	93	43	0.0135946885867847	3163	7167	54822,55129,7226,7809,5894,1831,338440,284525,1193,80727,55107,9311,6337,1188,40,266675,56302,1185,6446,11059,57101,6338,53373,65268,1182,7311,79054,196527,219931,50636,59341,94015,6262,55515,259232,1184,7316,162514,80036,57113,6339,7442,29850	TRPM7,ANO10,TRPM2,BSND,RAF1,TSC22D3,ANO9,SLC9C2,CLIC2,TTYH3,ANO1,ASIC3,SCNN1A,CLCNKB,ASIC2,BEST4,TRPV5,CLCN6,SGK1,WWP1,ANO2,SCNN1B,TPCN1,WNK2,CLCN3,UBA52,TRPM8,ANO6,TPCN2,ANO7,TRPV4,TTYH2,RYR2,ASIC4,NALCN,CLCN5,UBC,TRPV3,TRPM3,TRPC7,SCNN1D,TRPV1,TRPM5
REACT_16983	Amine ligand-binding receptors	0.379994344889983	-0.967598908240909	42	20	0.00632311097059753	3163	7167	152,3354,11255,3358,1128,1132,154,3360,1815,3274,3352,147,3363,1816,3362,148,1131,3269,1812,150	ADRA2C,HTR1E,HRH3,HTR2C,CHRM1,CHRM4,ADRB2,HTR4,DRD4,HRH2,HTR1D,ADRA1B,HTR7,DRD5,HTR6,ADRA1A,CHRM3,HRH1,DRD1,ADRA2A
REACT_22426	Asparagine N-linked glycosylation	0.386664429607587	-0.950198069064192	91	42	0.0132785330382548	3163	7167	4248,9945,6396,5589,79087,55757,2683,54344,8702,821,5373,84920,811,6484,6184,4245,9695,10113,144245,10802,9761,29929,11282,11253,80267,90411,91869,29926,51128,22872,79947,5372,4122,79694,1650,6675,3703,57171,79644,29925,85365,8703	MGAT3,GFPT2,SEC13,PRKCSH,ALG12,UGGT2,B4GALT1,DPM3,B4GALT4,CANX,PMM2,ALG10,CALR,ST3GAL4,RPN1,MGAT1,EDEM1,PREB,ALG10B,SEC24A,MLEC,ALG6,MGAT4B,MAN1B1,EDEM3,MCFD2,RFT1,GMPPA,SAR1B,SEC31A,DHDDS,PMM1,MAN2A2,MANEA,DDOST,UAP1,STT3A,DOLPP1,SRD5A3,GMPPB,ALG2,B4GALT3
REACT_16925	Glyoxylate metabolism	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	1610,9380,189	DAO,GRHPR,AGXT
REACT_22230	Synthesis of Dolichyl-phosphate	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	79947,57171,79644	DHDDS,DOLPP1,SRD5A3
REACT_16968	Dopamine receptors	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	1816,1815,1812	DRD5,DRD4,DRD1
REACT_204	ATM mediated response to DNA double-strand break	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	472,672,9656	ATM,BRCA1,MDC1
REACT_16970	Electric Transmission Across Gap Junctions	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	56666,84694,24145	PANX2,GJA10,PANX1
REACT_16881	Transmission across Electrical Synapses	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	56666,84694,24145	PANX2,GJA10,PANX1
REACT_18302	Leukotriene receptors	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	57105,1241,2840	CYSLTR2,LTB4R,GPR17
REACT_16943	Muscarinic acetylcholine receptors	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	1132,1131,1128	CHRM4,CHRM3,CHRM1
REACT_993	Propionyl-CoA catabolism	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	5096,4594,166785	PCCB,MUT,MMAA
REACT_532	Galactose catabolism	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	2584,5236,2582	GALK1,PGM1,GALE
REACT_900	FasL/ CD95L signaling	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	356,8772,355	FASLG,FADD,FAS
REACT_11046	NGF-independant TRKA activation	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	4915,117,4914	NTRK2,ADCYAP1R1,NTRK1
REACT_2077	RAF activation	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	3845,3265,5894	KRAS,HRAS,RAF1
REACT_1988	AMPK inhibits chREBP transcriptional activation activity	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	5563,51422,5565	PRKAA2,PRKAG2,PRKAB2
REACT_163810	Ficolins bind to repetitive carbohydrate structures on the target cell surface	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	2219,10747,2220	FCN1,MASP2,FCN2
REACT_9400	FGFR1b ligand binding and activation	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	2246,27006,2248	FGF1,FGF22,FGF3
REACT_11070	Vitamin B2 (riboflavin) metabolism	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	80308,5167,55312	FLAD1,ENPP1,RFK
REACT_121122	Acyl chain remodeling of DAG and TAG	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	8694,57104,84649	DGAT1,PNPLA2,DGAT2
REACT_116010	Sulfide oxidation to sulfate	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	58472,6821,1468	SQRDL,SUOX,SLC25A10
REACT_163743	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	9208,3661,1499	LRRFIP1,IRF3,CTNNB1
REACT_1924	ATM mediated phosphorylation of repair proteins	0.390966382710024	-0.939133700416791	5	3	0.00094846664558963	3163	7167	472,672,9656	ATM,BRCA1,MDC1
REACT_12076	Frs2-mediated activation	0.392854587856813	-0.934315741035186	18	9	0.00284539993676889	3163	7167	1399,5335,2889,5894,4914,3845,5605,3265,983	CRKL,PLCG1,RAPGEF1,RAF1,NTRK1,KRAS,MAP2K2,HRAS,CDK1
REACT_120836	Synthesis of PIPs at the Golgi membrane	0.392854587856813	-0.934315741035186	18	9	0.00284539993676889	3163	7167	7179,55300,56623,5298,22908,375,5286,55697,55361	TPTE,PI4K2B,INPP5E,PI4KB,SACM1L,ARF1,PIK3C2A,VAC14,PI4K2A
REACT_75900	Inflammasomes	0.392854587856813	-0.934315741035186	18	9	0.00284539993676889	3163	7167	10910,22861,9447,114548,3326,10628,351,9051,24145	SUGT1,NLRP1,AIM2,NLRP3,HSP90AB1,TXNIP,APP,PSTPIP1,PANX1
REACT_756	RNA Polymerase III Chain Elongation	0.392854587856813	-0.934315741035186	18	9	0.00284539993676889	3163	7167	661,5441,5440,55718,5434,84265,5437,51728,11178	POLR3D,POLR2L,POLR2K,POLR3E,POLR2E,POLR3GL,POLR2H,POLR3K,LZTS1
REACT_121324	Acyl chain remodelling of PG	0.392854587856813	-0.934315741035186	18	9	0.00284539993676889	3163	7167	283748,5321,255189,9926,254531,81579,79888,8399,100137049	PLA2G4D,PLA2G4A,PLA2G4F,LPGAT1,LPCAT4,PLA2G12A,LPCAT1,PLA2G10,PLA2G4B
REACT_20568	CREB phosphorylation through the activation of Ras	0.393963535098113	-0.931496924479669	29	14	0.00442617767941827	3163	7167	5170,5923,817,6196,6237,6195,816,5894,2902,88,1385,3265,818,815	PDPK1,RASGRF1,CAMK2D,RPS6KA2,RRAS,RPS6KA1,CAMK2B,RAF1,GRIN1,ACTN2,CREB1,HRAS,CAMK2G,CAMK2A
REACT_6823	Lipoprotein metabolism	0.393963535098113	-0.931496924479669	29	14	0.00442617767941827	3163	7167	51128,3931,4547,3339,5034,4018,81693,3949,336,649,949,3990,6382,9619	SAR1B,LCAT,MTTP,HSPG2,P4HB,LPA,AMN,LDLR,APOA2,BMP1,SCARB1,LIPC,SDC1,ABCG1
REACT_23891	Interleukin receptor SHC signaling	0.393963535098113	-0.931496924479669	29	14	0.00442617767941827	3163	7167	3562,3636,6464,5777,3635,5296,5295,5290,8503,3717,3560,1437,3265,3567	IL3,INPPL1,SHC1,PTPN6,INPP5D,PIK3R2,PIK3R1,PIK3CA,PIK3R3,JAK2,IL2RB,CSF2,HRAS,IL5
REACT_11063	Degradation of beta-catenin by the destruction complex	0.397622363403557	-0.922252559796663	69	32	0.0101169775529561	3163	7167	5689,7311,5684,5692,5721,324,5710,1452,5685,9491,7316,5704,5515,5529,5699,5687,122706,5696,5525,1499,5518,5714,5709,8312,5701,10213,6500,2932,10197,5528,5686,8945	PSMB1,UBA52,PSMA3,PSMB4,PSME2,APC,PSMD4,CSNK1A1,PSMA4,PSMF1,UBC,PSMC4,PPP2CA,PPP2R5E,PSMB10,PSMA6,PSMB11,PSMB8,PPP2R5A,CTNNB1,PPP2R1A,PSMD8,PSMD3,AXIN1,PSMC2,PSMD14,SKP1,GSK3B,PSME3,PPP2R5D,PSMA5,BTRC
REACT_120956	Cellular responses to stress	0.405011995334729	-0.903838594203763	244	110	0.0347771103382864	3163	7167	9134,126961,538,2878,3397,9588,2034,29855,6195,8349,8358,1026,1432,8290,898,5606,3490,54386,64682,6196,4001,5034,4790,51343,26277,10393,6045,51434,1032,3017,343,6647,7311,6923,8370,2077,9978,1019,79813,475,8550,1871,85236,23466,3021,8697,7422,8881,112398,3576,8337,128312,8338,3020,25828,1870,405,25913,3006,27327,8091,7323,51433,57634,57690,50488,54205,8970,2113,2950,3725,57332,5601,653604,5600,6774,6667,7296,23135,5609,7867,22955,6921,2353,7001,5052,7316,7324,1051,9261,847,996,10919,2114,3005,3091,8453,7027,10111,7322,472,23523,3159,4217,11065,2876,7013,29945,333932,54583	CCNE2,HIST2H3C,ATP7A,GPX3,ID1,PRDX6,EPAS1,UBN1,RPS6KA1,HIST2H2BE,HIST1H3B,CDKN1A,MAPK14,HIST3H3,CCNE1,MAP2K3,IGFBP7,TERF2IP,ANAPC1,RPS6KA2,LMNB1,P4HB,NFKB1,FZR1,TINF2,ANAPC10,RNF2,ANAPC7,CDKN2D,HIST1H2BD,AQP8,SOD1,UBA52,TCEB2,HIST2H4A,ERF,RBX1,CDK4,EHMT1,ATOX1,MAPKAPK5,E2F3,HIST1H2BK,CBX6,H3F3B,CDC23,VEGFA,CDC16,EGLN2,IL8,HIST2H2AA3,HIST3H2BB,HIST2H2AC,H3F3A,TXN2,E2F2,ARNT,POT1,HIST1H1C,TNRC6A,HMGA2,UBE2D3,ANAPC5,EP400,TNRC6C,MINK1,CYCS,HIST1H2BJ,ETS1,GSTP1,JUN,CBX8,MAPK9,HIST2H3D,MAPK11,STAT3,SP1,TXNRD1,KDM6B,MAP2K7,MAPKAPK3,SCMH1,TCEB1,FOS,PRDX2,PRDX1,UBC,UBE2E1,CEBPB,MAPKAPK2,CAT,CDC27,EHMT2,ETS2,H1F0,HIF1A,CUL2,TFDP1,RAD50,UBE2D2,ATM,CABIN1,HMGA1,MAP3K5,UBE2C,GPX1,TERF1,ANAPC4,HIST2H3A,EGLN1
REACT_9029	Cyclin A:Cdk2-associated events at S phase entry	0.40734112245599	-0.898104305869153	67	31	0.00980082200442618	3163	7167	9134,993,5689,7311,4149,5684,5692,902,5721,1026,5710,9491,5685,898,7316,5704,7465,5699,5687,5696,5709,5714,4609,5701,51343,10213,1163,6500,994,10197,5686	CCNE2,CDC25A,PSMB1,UBA52,MAX,PSMA3,PSMB4,CCNH,PSME2,CDKN1A,PSMD4,PSMF1,PSMA4,CCNE1,UBC,PSMC4,WEE1,PSMB10,PSMA6,PSMB8,PSMD3,PSMD8,MYC,PSMC2,FZR1,PSMD14,CKS1B,SKP1,CDC25B,PSME3,PSMA5
REACT_75780	G protein gated Potassium channels	0.407727512765398	-0.897156188565515	27	13	0.0041100221308884	3163	7167	3762,3768,3765,3759,2793,9568,2788,3763,2786,2782,3766,2783,548645	KCNJ5,KCNJ12,KCNJ9,KCNJ2,GNGT2,GABBR2,GNG7,KCNJ6,GNG4,GNB1,KCNJ10,GNB2,DNAJC25
REACT_75831	Activation of G protein gated Potassium channels	0.407727512765398	-0.897156188565515	27	13	0.0041100221308884	3163	7167	3762,3768,3765,3759,2793,9568,2788,3763,2786,2782,3766,2783,548645	KCNJ5,KCNJ12,KCNJ9,KCNJ2,GNGT2,GABBR2,GNG7,KCNJ6,GNG4,GNB1,KCNJ10,GNB2,DNAJC25
REACT_15523	Integrin alphaIIb beta3 signaling	0.407727512765398	-0.897156188565515	27	13	0.0041100221308884	3163	7167	5170,5770,2335,6464,207,7094,11069,7450,5747,10411,9564,6714,6850	PDPK1,PTPN1,FN1,SHC1,AKT1,TLN1,RAPGEF4,VWF,PTK2,RAPGEF3,BCAR1,SRC,SYK
REACT_25004	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.407727512765398	-0.897156188565515	27	13	0.0041100221308884	3163	7167	3762,3768,3765,3759,2793,9568,2788,3763,2786,2782,3766,2783,548645	KCNJ5,KCNJ12,KCNJ9,KCNJ2,GNGT2,GABBR2,GNG7,KCNJ6,GNG4,GNB1,KCNJ10,GNB2,DNAJC25
REACT_347	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.407727512765398	-0.897156188565515	27	13	0.0041100221308884	3163	7167	2976,661,5441,9328,6908,5440,55718,5434,84265,5437,2972,11178,51728	GTF3C2,POLR3D,POLR2L,GTF3C5,TBP,POLR2K,POLR3E,POLR2E,POLR3GL,POLR2H,BRF1,LZTS1,POLR3K
REACT_22279	Fatty acid, triacylglycerol, and ketone body metabolism	0.408928179087234	-0.894215739612746	188	85	0.0268732216250395	3163	7167	2180,6785,5565,27242,133522,6256,336,25942,64900,64834,6095,400569,23175,1666,85441,55326,9441,29841,7004,9572,55588,23171,90390,10498,51703,35,80205,10025,948,9969,4800,10555,50486,23305,406,96764,2168,5563,9612,4594,56894,55090,3995,2819,3157,84246,622,6720,54578,9443,8694,79888,10499,51144,6576,2222,6667,3156,7296,5096,9439,60481,79718,150763,56895,79071,2181,8841,2194,2274,166785,51129,57761,51422,3033,183,51586,47,254531,84649,9440,6907,57678,2101,37	ACSL1,ELOVL4,PRKAB2,TNFRSF21,PPARGC1B,RXRA,APOA2,SIN3A,LPIN3,ELOVL1,RORA,MED11,LPIN1,DECR1,HELZ2,AGPAT5,MED26,GRHL1,TEAD4,NR1D1,MED29,GPD1L,MED30,CARM1,ACSL5,ACADS,CHD9,MED16,CD36,MED13,NFYA,AGPAT2,G0S2,ACSL6,ARNTL,TGS1,FABP1,PRKAA2,NCOR2,MUT,AGPAT3,MED9,FADS3,GPD1,HMGCS1,MED10,BDH1,SREBF1,UGT1A6,MED7,DGAT1,LPCAT1,NCOA2,HSD17B12,SLC25A1,FDFT1,SP1,HMGCR,TXNRD1,PCCB,MED23,ELOVL5,TBL1XR1,GPAT2,AGPAT4,ELOVL6,ACSL3,HDAC3,FASN,FHL2,MMAA,ANGPTL4,TRIB3,PRKAG2,HADH,AGT,MED15,ACLY,LPCAT4,DGAT2,MED17,TBL1X,GPAM,ESRRA,ACADVL
REACT_120722	Acyl chain remodelling of PI	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	283748,5321,8605,255189,81579,79143,8399,123745	PLA2G4D,PLA2G4A,PLA2G4C,PLA2G4F,PLA2G12A,MBOAT7,PLA2G10,PLA2G4E
REACT_147707	Metabolism of Angiotensinogen to Angiotensins	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	183,1636,5972,1509,4311,2999,290,10159	AGT,ACE,REN,CTSD,MME,GZMH,ANPEP,ATP6AP2
REACT_1587	Homologous recombination repair of replication-independent double-strand breaks	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	3978,472,6118,5893,672,9656,7158,10111	LIG1,ATM,RPA2,RAD52,BRCA1,MDC1,TP53BP1,RAD50
REACT_23898	Rap1 signalling	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	5894,11069,23108,7534,10411,5566,5909,5567	RAF1,RAPGEF4,RAP1GAP2,YWHAZ,RAPGEF3,PRKACA,RAP1GAP,PRKACB
REACT_169121	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	8091,57634,23523,3159,4001,29855,3005,3006	HMGA2,EP400,CABIN1,HMGA1,LMNB1,UBN1,H1F0,HIST1H1C
REACT_1874	Homologous Recombination Repair	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	3978,472,6118,5893,672,9656,7158,10111	LIG1,ATM,RPA2,RAD52,BRCA1,MDC1,TP53BP1,RAD50
REACT_21368	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	7189,8517,6885,3654,5609,23118,5601,64127	TRAF6,IKBKG,MAP3K7,IRAK1,MAP2K7,TAB2,MAPK9,NOD2
REACT_115697	Prolactin receptor signaling	0.409223462020904	-0.89349391023136	16	8	0.00252924438823901	3163	7167	9978,5618,5781,6500,6776,3717,2688,8945	RBX1,PRLR,PTPN11,SKP1,STAT5A,JAK2,GH1,BTRC
REACT_89	Formation of apoptosome	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	54205,317	CYCS,APAF1
REACT_19411	Type II Na+/Pi cotransporters	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	6569,142680	SLC34A1,SLC34A3
REACT_121168	Synthesis of PIPs at the ER membrane	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	22908,55300	SACM1L,PI4K2B
REACT_11034	Regulation of gap junction activity	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	7082,6714	TJP1,SRC
REACT_115789	Serine biosynthesis	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	29968,5723	PSAT1,PSPH
REACT_13724	NFG and proNGF binds to p75NTR	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	4804,22986	NGFR,SORCS3
REACT_127	DNA Damage Reversal	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	221120,4255	ALKBH3,MGMT
REACT_11043	c-src mediated regulation of Cx43 function and closure of gap junctions	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	7082,6714	TJP1,SRC
REACT_23892	Transport of fatty acids	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	10999,28965	SLC27A4,SLC27A6
REACT_25367	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	79944,728294	L2HGDH,D2HGDH
REACT_160131	Fibronectin matrix formation	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	2335,3688	FN1,ITGB1
REACT_6222	NS1 Mediated Effects on Host Pathways	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	10898,8106	CPSF4,PABPN1
REACT_20508	Rhesus glycoproteins mediate ammonium transport.	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	51458,57127	RHCG,RHBG
REACT_12049	Signalling to STAT3	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	6774,4914	STAT3,NTRK1
REACT_121226	Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	2034,3091	EPAS1,HIF1A
REACT_19308	Arachidonate production from DAG	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	747,221955	DAGLA,DAGLB
REACT_1729	Cleavage of the damaged purine	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	4350,4595	MPG,MUTYH
REACT_626	Depurination	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	4350,4595	MPG,MUTYH
REACT_19180	Adrenaline signalling through Alpha-2 adrenergic receptor	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	152,150	ADRA2C,ADRA2A
REACT_367	Mitochondrial transcription initiation	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	64216,5442	TFB2M,POLRMT
REACT_419	Beta oxidation of butanoyl-CoA to acetyl-CoA	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	35,3033	ACADS,HADH
REACT_25012	Vitamins B6 activation to pyridoxal phosphate	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	55163,8566	PNPO,PDXK
REACT_6737	Formation of the active cofactor, UDP-glucuronate	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	7360,7358	UGP2,UGDH
REACT_14805	Interconversion of polyamines	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	54498,6303	SMOX,SAT1
REACT_2176	Recognition and association of DNA glycosylase with site containing an affected purine	0.412384290056681	-0.885799621510897	3	2	0.000632311097059753	3163	7167	4350,4595	MPG,MUTYH
REACT_25199	GABA receptor activation	0.414121505641203	-0.881595856330178	56	26	0.00822004426177679	3163	7167	3768,3759,9568,2788,2774,3763,107,2786,2566,2782,2570,3766,2783,548645,2554,3762,3765,2793,114,111,346562,112,109,2771,2567,113	KCNJ12,KCNJ2,GABBR2,GNG7,GNAL,KCNJ6,ADCY1,GNG4,GABRG2,GNB1,GABRR2,KCNJ10,GNB2,DNAJC25,GABRA1,KCNJ5,KCNJ9,GNGT2,ADCY8,ADCY5,GNAT3,ADCY6,ADCY3,GNAI2,GABRG3,ADCY7
REACT_150471	Separation of Sister Chromatids	0.414476746630644	-0.880738405785884	168	76	0.0240278216882706	3163	7167	5684,5721,83540,11004,64682,5696,5687,25909,5518,55746,5701,10393,23047,8379,10213,51434,81929,7311,1058,632,991,6232,701,8697,79682,3796,5515,5529,8881,7514,122706,5525,25936,79980,5714,5709,8243,151648,5528,5689,6396,51433,22919,1063,11243,54908,9491,91687,55920,699,79019,79902,5686,10726,11130,1060,9184,10274,5692,5905,5710,5685,7324,7316,5704,5699,996,113130,147841,80152,54820,10197,11065,3619,29945,5885	PSMA3,PSME2,NUF2,KIF2C,ANAPC1,PSMB8,PSMA6,AHCTF1,PPP2R1A,NUP133,PSMC2,ANAPC10,PDS5B,MAD1L1,PSMD14,ANAPC7,SEH1L,UBA52,CENPA,BGLAP,CDC20,RPS27,BUB1B,CDC23,CENPU,KIF2A,PPP2CA,PPP2R5E,CDC16,XPO1,PSMB11,PPP2R5A,NSL1,DSN1,PSMD8,PSMD3,SMC1A,SGOL1,PPP2R5D,PSMB1,SEC13,ANAPC5,MAPRE1,CENPF,PMF1,SPDL1,PSMF1,CENPL,RCC2,BUB1,CENPM,NUP85,PSMA5,NUDC,ZWINT,CENPC,BUB3,STAG1,PSMB4,RANGAP1,PSMD4,PSMA4,UBE2E1,UBC,PSMC4,PSMB10,CDC27,CDCA5,SPC24,CENPT,NDE1,PSME3,UBE2C,INCENP,ANAPC4,RAD21
REACT_172694	beta-catenin independent WNT signaling	0.420397295234611	-0.866555073790211	148	67	0.0211824217515017	3163	7167	5684,5721,51701,2782,5578,2783,5881,23002,5331,161,5696,5687,1499,5145,5216,5701,10213,1212,1856,815,8321,7311,2788,7481,3710,4772,57216,548645,122706,5714,5709,59345,1855,5158,27327,5689,57690,8325,27161,6929,9491,8323,5880,2793,5593,51764,6885,5330,5686,5692,144165,2786,23513,6932,5710,5685,6934,7316,5704,5699,54361,160,81029,3708,1211,7855,10197	PSMA3,PSME2,NLK,GNB1,PRKCA,GNB2,RAC3,DAAM1,PLCB3,AP2A2,PSMB8,PSMA6,CTNNB1,PDE6A,PFN1,PSMC2,PSMD14,CLTB,DVL2,CAMK2A,FZD1,UBA52,GNG7,WNT11,ITPR3,NFATC1,VANGL2,DNAJC25,PSMB11,PSMD8,PSMD3,GNB4,DVL1,PDE6B,TNRC6A,PSMB1,TNRC6C,FZD8,AGO2,TCF3,PSMF1,FZD6,RAC2,GNGT2,PRKG2,GNG13,MAP3K7,PLCB2,PSMA5,PSMB4,PRICKLE1,GNG4,SCRIB,TCF7,PSMD4,PSMA4,TCF7L2,UBC,PSMC4,PSMB10,WNT4,AP2A1,WNT5B,ITPR1,CLTA,FZD5,PSME3
REACT_18274	Regulation of Insulin Secretion by Glucagon-like Peptide-1	0.421477647545056	-0.863988533681742	45	21	0.00663926651912741	3163	7167	2740,11069,2788,5575,2786,2782,5577,3710,26251,5566,548645,2783,111,2793,114,59345,3708,112,51764,10411,5567	GLP1R,RAPGEF4,GNG7,PRKAR1B,GNG4,GNB1,PRKAR2B,ITPR3,KCNG2,PRKACA,DNAJC25,GNB2,ADCY5,GNGT2,ADCY8,GNB4,ITPR1,ADCY6,GNG13,RAPGEF3,PRKACB
REACT_2202	Effects of PIP2 hydrolysis	0.422541359471834	-0.861467944735014	25	12	0.00379386658235852	3163	7167	5583,747,8525,221955,1609,9162,3708,5580,57113,1606,8527,3710	PRKCH,DAGLA,DGKZ,DAGLB,DGKQ,DGKI,ITPR1,PRKCD,TRPC7,DGKA,DGKD,ITPR3
REACT_13415	p75NTR recruits signalling complexes	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	7189,7311,3654,8878,4804,3551,7316	TRAF6,UBA52,IRAK1,SQSTM1,NGFR,IKBKB,UBC
REACT_7987	Polymerase switching on the C-strand of the telomere	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	5983,5111,5981,5558,5424,57804,5425	RFC3,PCNA,RFC1,PRIM2,POLD1,POLD4,POLD2
REACT_1100	Golgi Cisternae Pericentriolar Stack Reorganization	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	26003,8615,5861,2801,891,983,81876	GORASP2,USO1,RAB1A,GOLGA2,CCNB1,CDK1,RAB1B
REACT_1838	Leading Strand Synthesis	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	5981,5111,5983,5558,5424,57804,5425	RFC1,PCNA,RFC3,PRIM2,POLD1,POLD4,POLD2
REACT_25026	TRAF3-dependent IRF activation pathway	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	7187,3665,3661,29110,57506,9641,7706	TRAF3,IRF7,IRF3,TBK1,MAVS,IKBKE,TRIM25
REACT_9483	FGFR1 ligand binding and activation	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	2246,2254,2249,27006,26281,2260,2248	FGF1,FGF9,FGF4,FGF22,FGF20,FGFR1,FGF3
REACT_160176	Cytosolic Iron-sulfur Cluster Assembly	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	8771,27158,9391,5424,4682,64428,10101	TNFRSF6B,NDOR1,CIAO1,POLD1,NUBP1,NARFL,NUBP2
REACT_1792	Polymerase switching	0.427573599254132	-0.849628843425528	14	7	0.00221308883970914	3163	7167	5981,5111,5983,5558,5424,57804,5425	RFC1,PCNA,RFC3,PRIM2,POLD1,POLD4,POLD2
REACT_13477	Transmission across Chemical Synapses	0.428262257944903	-0.848019518848603	200	90	0.0284539993676889	3163	7167	6582,84254,6195,5894,3763,9254,2782,5578,5566,3766,2783,2752,5331,161,6196,1739,2899,109,1312,1146,6512,5567,10369,815,113,1139,27092,81539,2036,2788,3312,6531,107,8973,548645,2554,3762,817,3765,114,59345,83988,80852,346562,4128,1145,784,774,55584,80331,2774,1141,2566,6538,88,2570,2890,1142,2793,5864,112,10815,51764,1385,2771,5330,818,2567,5170,5923,3768,6237,3759,777,9568,8224,773,2902,2786,1135,2900,1137,6804,160,111,816,1103,6571,43,3265	SLC22A2,CAMKK1,RPS6KA1,RAF1,KCNJ6,CACNA2D2,GNB1,PRKCA,PRKACA,KCNJ10,GNB2,GLUL,PLCB3,AP2A2,RPS6KA2,DLG1,GRIK3,ADCY3,COMT,CHRNG,SLC1A7,PRKACB,CACNG2,CAMK2A,ADCY7,CHRNA7,CACNG4,SLC38A1,EPB41L1,GNG7,HSPA8,SLC6A3,ADCY1,CHRNA6,DNAJC25,GABRA1,KCNJ5,CAMK2D,KCNJ9,ADCY8,GNB4,NCALD,GRIP2,GNAT3,MAOA,CHRNE,CACNB3,CACNA1B,CHRNA9,DNAJC5,GNAL,CHRNB2,GABRG2,SLC6A11,ACTN2,GABRR2,GRIA1,CHRNB3,GNGT2,RAB3A,ADCY6,CPLX1,GNG13,CREB1,GNAI2,PLCB2,CAMK2G,GABRG3,PDPK1,RASGRF1,KCNJ12,RRAS,KCNJ2,CACNA1E,GABBR2,SYN3,CACNA1A,GRIN1,GNG4,CHRNA2,GRIK4,CHRNA4,STX1A,AP2A1,ADCY5,CAMK2B,CHAT,SLC18A2,ACHE,HRAS
REACT_21384	Thrombin signalling through proteinase activated receptors (PARs)	0.429563309614998	-0.844986145358897	34	16	0.00505848877647803	3163	7167	2147,2769,2788,2786,2782,9002,6714,2783,548645,2767,9630,2768,59345,2793,408,51764	F2,GNA15,GNG7,GNG4,GNB1,F2RL3,SRC,GNB2,DNAJC25,GNA11,GNA14,GNA12,GNB4,GNGT2,ARRB1,GNG13
REACT_75776	NOD1/2 Signaling Pathway	0.429563309614998	-0.844986145358897	34	16	0.00505848877647803	3163	7167	7189,8517,1540,7128,3654,330,23118,64170,387522,3551,64127,5600,6885,1432,329,6300	TRAF6,IKBKG,CYLD,TNFAIP3,IRAK1,BIRC3,TAB2,CARD9,TMEM189-UBE2V1,IKBKB,NOD2,MAPK11,MAP3K7,MAPK14,BIRC2,MAPK12
REACT_6346	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.433836241766628	-0.83508813920438	43	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_6162	Tat-mediated elongation of the HIV-1 transcript	0.433836241766628	-0.83508813920438	43	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_6274	HIV Transcription Elongation	0.433836241766628	-0.83508813920438	43	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_63	RNA Polymerase III Transcription Termination	0.43857801654547	-0.824217566129846	23	11	0.00347771103382864	3163	7167	661,5441,5440,55718,5434,84265,4782,5437,11178,51728,4784	POLR3D,POLR2L,POLR2K,POLR3E,POLR2E,POLR3GL,NFIC,POLR2H,LZTS1,POLR3K,NFIX
REACT_6261	Abortive elongation of HIV-1 transcript in the absence of Tat	0.43857801654547	-0.824217566129846	23	11	0.00347771103382864	3163	7167	9150,6827,5438,5439,5441,5440,5434,22916,5437,7469,25920	CTDP1,SUPT4H1,POLR2I,POLR2J,POLR2L,POLR2K,POLR2E,NCBP2,POLR2H,NELFA,NELFB
REACT_21254	Presynaptic function of Kainate receptors	0.43857801654547	-0.824217566129846	23	11	0.00347771103382864	3163	7167	2793,59345,2788,2899,2786,2782,51764,5330,548645,2783,5331	GNGT2,GNB4,GNG7,GRIK3,GNG4,GNB1,GNG13,PLCB2,DNAJC25,GNB2,PLCB3
REACT_12417	MicroRNA (miRNA) Biogenesis	0.43857801654547	-0.824217566129846	23	11	0.00347771103382864	3163	7167	5438,5439,5441,54487,5440,23405,27161,5434,6895,5437,8575	POLR2I,POLR2J,POLR2L,DGCR8,POLR2K,DICER1,AGO2,POLR2E,TARBP2,POLR2H,PRKRA
REACT_25266	Reactions specific to the hybrid N-glycan synthesis pathway	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	4248	MGAT3
5470763	FBXW7 Mutants and NOTCH1 in Cancer	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
5470758	Activated NOTCH1 Transmits Signal to the Nucleus	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_1396	COX reactions	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	5742	PTGS1
REACT_163652	Regulation by TREX1	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	11277	TREX1
REACT_121286	Signaling by FGFR4 mutants	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	2264	FGFR4
5470762	Signaling by NOTCH1 in Cancer	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
5470759	Signaling by NOTCH1	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_2229	Resolution of D-loop structures	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	3978	LIG1
171286	Synthesis and processing of ENV and VPU	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	5045	FURIN
5470760	Signaling by NOTCH	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
5258767	Hemostasis	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	7409	VAV1
5470766	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
5470764	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
5470373	Disease	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_120827	Signaling by FGFR1 amplification mutants	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	2260	FGFR1
5417619	CRMPs in Sema3A signaling	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	5362	PLXNA2
5258771	GPVI-mediated activation cascade	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	7409	VAV1
REACT_610	Mitochondrial transcription termination	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	7978	MTERF
5470761	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_121011	t(4;14) translocations of FGFR3	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	2261	FGFR3
5417537	Semaphorin interactions	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	5362	PLXNA2
REACT_6198	Viral RNP Complexes in the Host Cell Nucleus	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	3304	HSPA1B
REACT_977	Resolution of D-loop structures through Holliday junction intermediates	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	3978	LIG1
REACT_1662	ABH3 mediated Reversal of Alkylation Damage	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	221120	ALKBH3
5470451	Signal Transduction	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_8	Translesion synthesis by HREV1	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	51455	REV1
REACT_6147	Entry of Influenza Virion into Host Cell via Endocytosis	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1211	CLTA
5258766	Platelet activation, signaling and aggregation	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	7409	VAV1
5470765	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.441328310312212	-0.81796621268586	1	1	0.000316155548529877	3163	7167	1840	DTX1
REACT_383	DNA Replication	0.442234880073633	-0.815914135167428	106	48	0.0151754663294341	3163	7167	5689,55388,5684,5721,81620,10926,3978,1026,5424,9491,4173,6118,5687,5111,5696,4174,5701,51343,10213,57804,5686,9837,4999,7311,5983,5692,5558,1871,990,4171,5710,5685,84296,7316,5704,5699,122706,51659,5426,5709,5714,84515,29935,5981,10197,1870,5425,4172	PSMB1,MCM10,PSMA3,PSME2,CDT1,DBF4,LIG1,CDKN1A,POLD1,PSMF1,MCM4,RPA2,PSMA6,PCNA,PSMB8,MCM5,PSMC2,FZR1,PSMD14,POLD4,PSMA5,GINS1,ORC2,UBA52,RFC3,PSMB4,PRIM2,E2F3,CDC6,MCM2,PSMD4,PSMA4,GINS4,UBC,PSMC4,PSMB10,PSMB11,GINS2,POLE,PSMD3,PSMD8,MCM8,RPA4,RFC1,PSME3,E2F2,POLD2,MCM3
REACT_118682	Activation of Matrix Metalloproteinases	0.443848690739449	-0.812271561253731	32	15	0.00474233322794815	3163	7167	4318,1504,4324,4320,4317,4326,1515,4313,5045,4323,440387,80781,1513,5645,3817	MMP9,CTRB1,MMP15,MMP11,MMP8,MMP17,CTSV,MMP2,FURIN,MMP14,CTRB2,COL18A1,CTSK,PRSS2,KLK2
REACT_17064	Serotonin receptors	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	3363,3354,3358,3360,3352,3362	HTR7,HTR1E,HTR2C,HTR4,HTR1D,HTR6
REACT_25039	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	8737,8517,57506,7706,3551,8772	RIPK1,IKBKG,MAVS,TRIM25,IKBKB,FADD
REACT_9510	FGFR3c ligand binding and activation	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	2246,2254,2261,2249,26281,8817	FGF1,FGF9,FGFR3,FGF4,FGF20,FGF18
REACT_121249	Signaling by FGFR3 mutants	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	2246,2254,2261,2249,26281,8817	FGF1,FGF9,FGFR3,FGF4,FGF20,FGF18
REACT_9439	FGFR3 ligand binding and activation	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	2246,2254,2261,2249,26281,8817	FGF1,FGF9,FGFR3,FGF4,FGF20,FGF18
REACT_121337	Signaling by activated point mutants of FGFR3	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	2246,2254,2261,2249,26281,8817	FGF1,FGF9,FGFR3,FGF4,FGF20,FGF18
REACT_115893	Membrane binding and targetting of GAG proteins	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	7251,51160,155382,7311,55048,7316	TSG101,VPS28,VPS37D,UBA52,VPS37C,UBC
REACT_15418	Norepinephrine Neurotransmitter Release Cycle	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	6582,4128,10815,6804,6571,5864	SLC22A2,MAOA,CPLX1,STX1A,SLC18A2,RAB3A
174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.44851984321086	-0.801802354959525	12	6	0.00189693329117926	3163	7167	7251,51160,155382,7311,55048,7316	TSG101,VPS28,VPS37D,UBA52,VPS37C,UBC
REACT_6871	APC/C:Cdc20 mediated degradation of Securin	0.450386538486454	-0.797649090510828	68	31	0.00980082200442618	3163	7167	5689,51433,7311,5684,5692,5721,991,5710,8697,9491,5685,7324,7316,5704,64682,5699,5687,5696,122706,8881,996,5709,5714,5701,10393,10213,51434,10197,11065,5686,29945	PSMB1,ANAPC5,UBA52,PSMA3,PSMB4,PSME2,CDC20,PSMD4,CDC23,PSMF1,PSMA4,UBE2E1,UBC,PSMC4,ANAPC1,PSMB10,PSMA6,PSMB8,PSMB11,CDC16,CDC27,PSMD3,PSMD8,PSMC2,ANAPC10,PSMD14,ANAPC7,PSME3,UBE2C,PSMA5,ANAPC4
REACT_118656	Activation of NF-kappaB in B Cells	0.450386538486454	-0.797649090510828	68	31	0.00980082200442618	3163	7167	23291,5689,7311,5684,5692,4794,5721,10892,5710,5685,9491,7316,5704,8517,5699,5687,122706,5696,5714,5709,4792,4790,3551,5701,10213,6500,6885,10197,646626,5686,8945	FBXW11,PSMB1,UBA52,PSMA3,PSMB4,NFKBIE,PSME2,MALT1,PSMD4,PSMA4,PSMF1,UBC,PSMC4,IKBKG,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,NFKBIA,NFKB1,IKBKB,PSMC2,PSMD14,SKP1,MAP3K7,PSME3,LOC646626,PSMA5,BTRC
REACT_6828	APC/C-mediated degradation of cell cycle proteins	0.450951689653071	-0.796395063502905	86	39	0.0123300663926652	3163	7167	5689,51433,5684,5721,891,9491,26271,64682,5687,5696,5701,51343,10393,10213,51434,5686,7311,5692,9184,991,701,8697,5710,5685,983,7316,7324,5704,5699,8881,122706,996,5709,5714,6500,10197,11065,29945,8945	PSMB1,ANAPC5,PSMA3,PSME2,CCNB1,PSMF1,FBXO5,ANAPC1,PSMA6,PSMB8,PSMC2,FZR1,ANAPC10,PSMD14,ANAPC7,PSMA5,UBA52,PSMB4,BUB3,CDC20,BUB1B,CDC23,PSMD4,PSMA4,CDK1,UBC,UBE2E1,PSMC4,PSMB10,CDC16,PSMB11,CDC27,PSMD3,PSMD8,SKP1,PSME3,UBE2C,ANAPC4,BTRC
REACT_21279	Regulation of mitotic cell cycle	0.450951689653071	-0.796395063502905	86	39	0.0123300663926652	3163	7167	51433,5689,5684,5721,891,9491,26271,64682,5687,5696,51343,5701,10393,10213,51434,5686,7311,9184,5692,991,701,8697,5710,5685,983,7316,7324,5704,5699,122706,8881,996,5709,5714,6500,10197,11065,29945,8945	ANAPC5,PSMB1,PSMA3,PSME2,CCNB1,PSMF1,FBXO5,ANAPC1,PSMA6,PSMB8,FZR1,PSMC2,ANAPC10,PSMD14,ANAPC7,PSMA5,UBA52,BUB3,PSMB4,CDC20,BUB1B,CDC23,PSMD4,PSMA4,CDK1,UBC,UBE2E1,PSMC4,PSMB10,PSMB11,CDC16,CDC27,PSMD3,PSMD8,SKP1,PSME3,UBE2C,ANAPC4,BTRC
REACT_257	Formation of incision complex in GG-NER	0.456058588442103	-0.785133994295375	21	10	0.00316155548529877	3163	7167	6118,1643,2967,2067,902,2968,7507,5887,2072,1642	RPA2,DDB2,GTF2H3,ERCC1,CCNH,GTF2H4,XPA,RAD23B,ERCC4,DDB1
REACT_311	Dual incision reaction in GG-NER	0.456058588442103	-0.785133994295375	21	10	0.00316155548529877	3163	7167	6118,1643,2967,2067,902,2968,7507,5887,2072,1642	RPA2,DDB2,GTF2H3,ERCC1,CCNH,GTF2H4,XPA,RAD23B,ERCC4,DDB1
REACT_118607	Signaling by Hippo	0.456058588442103	-0.785133994295375	21	10	0.00316155548529877	3163	7167	51421,9414,261734,154810,6788,23286,7082,7531,60485,1856	AMOTL2,TJP2,NPHP4,AMOTL1,STK3,WWC1,TJP1,YWHAE,SAV1,DVL2
REACT_160156	The canonical retinoid cycle in rods (twilight vision)	0.456058588442103	-0.785133994295375	21	10	0.00316155548529877	3163	7167	3292,5959,157506,4647,6017,8630,121214,64220,5949,9227	HSD17B1,RDH5,RDH10,MYO7A,RLBP1,HSD17B6,SDR9C7,STRA6,RBP3,LRAT
REACT_19373	Tight junction interactions	0.459075539231047	-0.778540508974203	30	14	0.00442617767941827	3163	7167	7122,84552,9080,1364,50848,64398,1365,9074,23562,9071,84612,1366,56288,149461	CLDN5,PARD6G,CLDN9,CLDN4,F11R,MPP5,CLDN3,CLDN6,CLDN14,CLDN10,PARD6B,CLDN7,PARD3,CLDN19
REACT_19388	G-protein beta:gamma signalling	0.459075539231047	-0.778540508974203	30	14	0.00442617767941827	3163	7167	5170,207,23533,2793,59345,10000,2788,2786,2782,51764,5330,2783,548645,5331	PDPK1,AKT1,PIK3R5,GNGT2,GNB4,AKT3,GNG7,GNG4,GNB1,GNG13,PLCB2,GNB2,DNAJC25,PLCB3
REACT_6359	Budding and maturation of HIV virion	0.459075539231047	-0.778540508974203	30	14	0.00442617767941827	3163	7167	51160,155382,7311,29082,10015,79643,9525,7251,128866,27183,51652,55048,91782,7316	VPS28,VPS37D,UBA52,CHMP4A,PDCD6IP,CHMP6,VPS4B,TSG101,CHMP4B,VPS4A,CHMP3,VPS37C,CHMP7,UBC
REACT_1574	Cyclin E associated events during G1/S transition	0.461211718999274	-0.77389808111111	66	30	0.0094846664558963	3163	7167	9134,993,5689,7311,4149,5684,5692,902,5721,1026,9088,5710,9491,5685,898,7316,5704,7465,5699,5687,5696,5709,5714,4609,5701,10213,1163,6500,10197,5686	CCNE2,CDC25A,PSMB1,UBA52,MAX,PSMA3,PSMB4,CCNH,PSME2,CDKN1A,PKMYT1,PSMD4,PSMF1,PSMA4,CCNE1,UBC,PSMC4,WEE1,PSMB10,PSMA6,PSMB8,PSMD3,PSMD8,MYC,PSMC2,PSMD14,CKS1B,SKP1,PSME3,PSMA5
REACT_6288	Host Interactions of HIV factors	0.465417337799278	-0.764820775264056	136	61	0.0192854884603225	3163	7167	5689,920,5684,5721,4869,567,375,1794,9491,3105,129401,11097,161,10053,5696,5687,23225,653653,55746,919,5902,5701,8907,10213,51606,130340,79902,81929,3837,5686,7311,5692,6923,9978,8905,5905,6921,5710,8021,5685,7316,5704,7175,5699,2534,7514,122706,291,904,1104,5714,5709,1025,160,9688,6500,3159,10197,940,8945,8086	PSMB1,CD4,PSMA3,PSME2,NPM1,B2M,ARF1,DOCK2,PSMF1,HLA-A,NUP35,NUPL2,AP2A2,AP1M2,PSMB8,PSMA6,NUP210,LOC653653,NUP133,CD247,RANBP1,PSMC2,AP1M1,PSMD14,ATP6V1H,AP1S3,NUP85,SEH1L,KPNB1,PSMA5,UBA52,PSMB4,TCEB2,RBX1,AP1S2,RANGAP1,TCEB1,PSMD4,NUP214,PSMA4,UBC,PSMC4,TPR,PSMB10,FYN,XPO1,PSMB11,SLC25A4,CCNT1,RCC1,PSMD8,PSMD3,CDK9,AP2A1,NUP93,SKP1,HMGA1,PSME3,CD28,BTRC,AAAS
REACT_25218	Stabilization of mRNA by HuR	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	7514,5578,8021,6418,5580	XPO1,PRKCA,NUP214,SET,PRKCD
REACT_1321	E2F-enabled inhibition of pre-replication complex formation	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	993,4999,891,983,84515	CDC25A,ORC2,CCNB1,CDK1,MCM8
REACT_22128	Role of DCC in regulating apoptosis	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	23604,219699,90249,1630,1613	DAPK2,UNC5B,UNC5A,DCC,DAPK3
REACT_7999	Removal of the Flap Intermediate from the C-strand	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	6118,5111,5424,57804,5425	RPA2,PCNA,POLD1,POLD4,POLD2
REACT_634	RAF/MAP kinase cascade	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	3845,3265,983,5894,5605	KRAS,HRAS,CDK1,RAF1,MAP2K2
REACT_6946	Methylation	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	27430,191,1312,4837,4548	MAT2B,AHCY,COMT,NNMT,MTR
REACT_150421	Cohesin Loading onto Chromatin	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	23383,10274,8243,23047,5885	MAU2,STAG1,SMC1A,PDS5B,RAD21
REACT_22228	Role of second messengers in netrin-1 signaling	0.473031282115759	-0.748593757125776	10	5	0.00158077774264938	3163	7167	5306,5335,9423,1630,57113	PITPNA,PLCG1,NTN1,DCC,TRPC7
REACT_6821	SCF-beta-TrCP mediated degradation of Emi1	0.473274063358532	-0.748080643152023	55	25	0.00790388871324692	3163	7167	5689,7311,5684,5692,5721,991,5710,9491,5685,7316,26271,5704,5699,5687,122706,5696,5709,5714,51343,5701,10213,6500,10197,5686,8945	PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDC20,PSMD4,PSMF1,PSMA4,UBC,FBXO5,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,FZR1,PSMC2,PSMD14,SKP1,PSME3,PSMA5,BTRC
REACT_16952	Protein folding	0.473274063358532	-0.748080643152023	55	25	0.00790388871324692	3163	7167	10576,7280,10383,26272,8877,7203,63971,84617,26270,26985,5201,10376,22948,26234,5204,11328,7278,4157,60,55294,10574,54461,10381,6905,7277	CCT2,TUBB2A,TUBB4B,FBXO4,SPHK1,CCT3,KIF13A,TUBB6,FBXO6,AP3M1,PFDN1,TUBA1B,CCT5,FBXL5,PFDN5,FKBP9,TUBA3C,MC1R,ACTB,FBXW7,CCT7,FBXW5,TUBB3,TBCE,TUBA4A
REACT_1628	Transcription-coupled NER (TC-NER)	0.474116153954939	-0.746302936769194	46	21	0.00663926651912741	3163	7167	2967,2067,5438,5983,902,5441,5440,56949,3978,2072,5424,6118,5111,5439,5426,2968,5434,5437,5981,57804,5425	GTF2H3,ERCC1,POLR2I,RFC3,CCNH,POLR2L,POLR2K,XAB2,LIG1,ERCC4,POLD1,RPA2,PCNA,POLR2J,POLE,GTF2H4,POLR2E,POLR2H,RFC1,POLD4,POLD2
REACT_111057	Signaling by NODAL	0.475271988173523	-0.743868032143046	19	9	0.00284539993676889	3163	7167	4088,7044,4087,10637,2657,5045,8928,4089,5046	SMAD3,LEFTY2,SMAD2,LEFTY1,GDF1,FURIN,FOXH1,SMAD4,PCSK6
REACT_121238	Synthesis of PC	0.475271988173523	-0.743868032143046	19	9	0.00284539993676889	3163	7167	1120,64900,56994,10400,80736,43,1103,23175,23446	CHKB,LPIN3,CHPT1,PEMT,SLC44A4,ACHE,CHAT,LPIN1,SLC44A1
REACT_16967	Post-chaperonin tubulin folding pathway	0.475271988173523	-0.743868032143046	19	9	0.00284539993676889	3163	7167	7280,7278,10383,4157,84617,10381,10376,6905,7277	TUBB2A,TUBA3C,TUBB4B,MC1R,TUBB6,TUBB3,TUBA1B,TBCE,TUBA4A
REACT_23905	Platelet calcium homeostasis	0.475271988173523	-0.743868032143046	19	9	0.00284539993676889	3163	7167	5023,492,489,3708,57113,491,84876,3710,493	P2RX1,ATP2B3,ATP2A3,ITPR1,TRPC7,ATP2B2,ORAI1,ITPR3,ATP2B4
REACT_25374	IKK complex recruitment mediated by RIP1	0.475368152156699	-0.743665717977202	28	13	0.0041100221308884	3163	7167	7323,7189,8517,7311,330,387522,3551,7322,23098,8737,929,329,7316	UBE2D3,TRAF6,IKBKG,UBA52,BIRC3,TMEM189-UBE2V1,IKBKB,UBE2D2,SARM1,RIPK1,CD14,BIRC2,UBC
REACT_25283	Transferrin endocytosis and recycling	0.475368152156699	-0.743665717977202	28	13	0.0041100221308884	3163	7167	533,10312,127124,90423,55240,527,528,51606,8992,9114,7037,525,9550	ATP6V0B,TCIRG1,ATP6V1G3,ATP6V1E2,STEAP3,ATP6V0C,ATP6V1C1,ATP6V1H,ATP6V0E1,ATP6V0D1,TFRC,ATP6V1B1,ATP6V1G1
REACT_15518	Transmembrane transport of small molecules	0.481145686221241	-0.731585172779013	537	238	0.0752450205501107	3163	7167	56606,89872,6581,1831,85413,9152,358,9197,2782,23456,284525,366,6574,51458,80024,28232,1193,525,57835,1188,23225,368,5002,56302,23446,20,109,1836,6338,57181,6512,5567,81929,343,7311,6559,492,10257,142680,348932,81539,2788,6531,259232,1244,5577,26503,28982,1184,51761,23539,162514,114,59345,8714,527,169026,29985,8992,8086,9356,10723,54822,489,2743,90423,10861,6522,495,80727,55107,129401,7780,10347,9154,11097,9311,10999,6548,112,51606,353189,6558,9114,79902,65268,2567,26266,9498,206358,196527,59341,345274,94015,6262,53828,55515,148229,364,374868,28231,6533,285242,486,80036,57113,3099,6508,9688,6569,11194,7442,121260,6582,538,10058,7226,64924,1951,6528,29988,5894,7809,6513,9123,5566,3162,2783,27173,6833,533,55630,6337,5825,55746,83697,57127,1185,55240,56301,57468,477,2741,9550,6584,113,4645,1182,6578,340273,79054,480,50636,65010,107,115019,360,481,57198,8021,548645,2554,476,2645,10312,2542,6575,6339,9497,23428,55129,10079,80736,254428,2566,6538,2570,338440,6523,8766,6549,7037,9057,10351,6534,23120,40,6509,28965,266675,2793,55315,1468,6521,5205,6446,55117,215,11059,51764,57101,3101,496,53373,5824,219931,5575,81031,491,2786,363,23250,92579,7316,7175,283652,222962,160728,111,11136,6550,8140,127124,340024,3098,528,9153,7779,10991,441509,6571,124935,6583,155184,493,29850,478,9619	SLC2A9,AQP10,SLC22A3,TSC22D3,SLC22A16,SLC6A5,AQP1,SLC33A1,GNB1,ABCB10,SLC9C2,AQP9,SLC20A1,RHCG,SLC8B1,SLCO3A1,CLIC2,ATP6V1B1,SLC4A5,CLCNKB,NUP210,ABCC6,SLC22A18,TRPV5,SLC44A1,ABCA2,ADCY3,SLC26A2,SCNN1B,SLC39A10,SLC1A7,PRKACB,SEH1L,AQP8,UBA52,SLC12A3,ATP2B3,ABCC4,SLC34A3,SLC6A18,SLC38A1,GNG7,SLC6A3,NALCN,ABCC2,PRKAR2B,SLC17A5,FLVCR1,CLCN5,ATP8A2,SLC16A8,TRPV3,ADCY8,GNB4,ABCC3,ATP6V0C,SLC30A8,SLC39A3,ATP6V0E1,AAAS,SLC22A6,SLC12A7,TRPM7,ATP2A3,GLRB,ATP6V1E2,SLC26A1,SLC4A2,ATP4A,TTYH3,ANO1,NUP35,SLC30A2,ABCA7,SLC28A1,NUPL2,ASIC3,SLC27A4,SLC9A1,ADCY6,ATP6V1H,SLCO4C1,SLC12A2,ATP6V0D1,NUP85,WNK2,GABRG3,SLC13A4,SLC4A8,SLC36A1,ANO6,TRPV4,SLC10A6,TTYH2,RYR2,FXYD4,ASIC4,ATP8B3,AQP7,ATP9B,SLCO4A1,SLC6A6,HTR3E,FXYD2,TRPM3,TRPC7,HK2,SLC4A3,NUP93,SLC34A1,ABCB8,TRPV1,SLC15A4,SLC22A2,ATP7A,ABCB6,TRPM2,SLC30A5,CELSR3,SLC5A5,SLC2A8,RAF1,BSND,SLC2A1,SLC16A3,PRKACA,HMOX1,GNB2,SLC39A1,ABCC8,ATP6V0B,SLC39A4,SCNN1A,ABCD3,NUP133,SLC4A9,RHBG,CLCN6,STEAP3,SLC7A10,SLC12A5,ATP1A2,GLRA1,ATP6V1G1,SLC22A5,ADCY7,MYO5B,CLCN3,SLCO2A1,ABCB5,TRPM8,ATP1A4,ANO7,SLC26A6,ADCY1,SLC26A9,AQP3,ATP1B1,ATP8B2,NUP214,DNAJC25,GABRA1,ATP1A1,GCK,TCIRG1,SLC37A4,SLC20A2,SCNN1D,SLC4A7,SLC7A8,ANO10,ATP9A,SLC44A4,SLC41A1,GABRG2,SLC6A11,GABRR2,ANO9,SLC5A1,RAB11A,SLC9A2,TFRC,SLC7A6,ABCA8,SLC6A7,ATP10B,ASIC2,SLC1A4,SLC27A6,BEST4,GNGT2,SLC29A3,SLC25A10,SLC4A1,ATP8B1,SGK1,SLC6A15,ABCD1,WWP1,GNG13,ANO2,HK3,ATP4B,TPCN1,PEX19,TPCN2,PRKAR1B,SLC2A10,ATP2B2,GNG4,AQP6,ATP11A,G6PC3,UBC,TPR,SLC24A5,SLC29A4,SLC5A8,ADCY5,SLC7A9,SLC9A3,SLC7A5,ATP6V1G3,SLC6A19,HK1,ATP6V1C1,SLC28A2,SLC30A1,SLC38A3,GLRA4,SLC18A2,SLC43A2,SLC22A4,SLC2A7,ATP2B4,TRPM5,ATP1A3,ABCG1
REACT_833	RNA Polymerase II Transcription Elongation	0.487743324822108	-0.717965985226881	44	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_1845	Formation of RNA Pol II elongation complex	0.487743324822108	-0.717965985226881	44	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_22201	Formation of HIV elongation complex in the absence of HIV Tat	0.487743324822108	-0.717965985226881	44	20	0.00632311097059753	3163	7167	9150,2967,5438,902,6923,5441,5440,6924,6921,7469,8178,6827,5439,2968,904,1025,5434,22916,5437,25920	CTDP1,GTF2H3,POLR2I,CCNH,TCEB2,POLR2L,POLR2K,TCEB3,TCEB1,NELFA,ELL,SUPT4H1,POLR2J,GTF2H4,CCNT1,CDK9,POLR2E,NCBP2,POLR2H,NELFB
REACT_6916	Interactions of Rev with host cellular proteins	0.490065172090193	-0.713216892456048	35	16	0.00505848877647803	3163	7167	11097,7175,23225,7514,1104,55746,5902,9688,4869,5905,8021,79902,81929,3837,8086,129401	NUPL2,TPR,NUP210,XPO1,RCC1,NUP133,RANBP1,NUP93,NPM1,RANGAP1,NUP214,NUP85,SEH1L,KPNB1,AAAS,NUP35
REACT_22433	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.490065172090193	-0.713216892456048	35	16	0.00505848877647803	3163	7167	9945,29929,79087,54344,5373,91869,29926,84920,5372,79947,6675,57171,79644,29925,85365,144245	GFPT2,ALG6,ALG12,DPM3,PMM2,RFT1,GMPPA,ALG10,PMM1,DHDDS,UAP1,DOLPP1,SRD5A3,GMPPB,ALG2,ALG10B
REACT_19287	Lysosome Vesicle Biogenesis	0.4928775824537	-0.707494447226782	26	12	0.00379386658235852	3163	7167	10053,653653,63915,8905,3312,1785,8907,408,1211,375,130340,4074	AP1M2,LOC653653,BLOC1S5,AP1S2,HSPA8,DNM2,AP1M1,ARRB1,CLTA,ARF1,AP1S3,M6PR
REACT_22266	Interaction between L1 and Ankyrins	0.4928775824537	-0.707494447226782	26	12	0.00379386658235852	3163	7167	3785,286,3786,288,51332,23114,6329,3897,55800,6710,57731,4897	KCNQ2,ANK1,KCNQ3,ANK3,SPTBN5,NFASC,SCN4A,L1CAM,SCN3B,SPTB,SPTBN4,NRCAM
REACT_549	Activation of BAD and translocation to mitochondria	0.496605599454738	-0.699959130388197	17	8	0.00252924438823901	3163	7167	10971,7534,5533,207,7531,637,10000,2810	YWHAQ,YWHAZ,PPP3CC,AKT1,YWHAE,BID,AKT3,SFN
REACT_20530	Zinc transporters	0.496605599454738	-0.699959130388197	17	8	0.00252924438823901	3163	7167	55630,64924,169026,7779,29985,57181,7780,27173	SLC39A4,SLC30A5,SLC30A8,SLC30A1,SLC39A3,SLC39A10,SLC30A2,SLC39A1
REACT_952	Synthesis of glycosylphosphatidylinositol (GPI)	0.496605599454738	-0.699959130388197	17	8	0.00252924438823901	3163	7167	5279,93183,80031,5277,9091,5281,54872,55650	PIGC,PIGM,SEMA6D,PIGA,PIGQ,PIGF,PIGG,PIGV
REACT_6841	Chylomicron-mediated lipid transport	0.496605599454738	-0.699959130388197	17	8	0.00252924438823901	3163	7167	51128,4547,3339,3990,6382,5034,3949,336	SAR1B,MTTP,HSPG2,LIPC,SDC1,P4HB,LDLR,APOA2
REACT_11036	Glucocorticoid biosynthesis	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	1584,1589,3290,1585	CYP11B1,CYP21A2,HSD11B1,CYP11B2
REACT_12583	VEGF binds to VEGFR leading to receptor dimerization	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	5228,7422,2324,2321	PGF,VEGFA,FLT4,FLT1
REACT_1298	Lysine catabolism	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	501,4967,2639,1743	ALDH7A1,OGDH,GCDH,DLST
REACT_804	Base-Excision Repair, AP Site Formation	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	4350,4913,4595,8930	MPG,NTHL1,MUTYH,MBD4
5416964	Developmental Biology	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	51332,57731,6710,5362	SPTBN5,SPTBN4,SPTB,PLXNA2
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	27113,90427,637,5366	BBC3,BMF,BID,PMAIP1
REACT_15292	Thyroxine biosynthesis	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	7173,389434,6528,1735	TPO,IYD,SLC5A5,DIO3
REACT_13778	Regulation of gene expression in early pancreatic precursor cells	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	3175,390874,3651,2494	ONECUT1,ONECUT3,PDX1,NR5A2
REACT_19266	Sema4D mediated inhibition of cell attachment and migration	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	4233,6237,10507,5364	MET,RRAS,SEMA4D,PLXNB1
REACT_19372	Organic anion transporters	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	26503,6528,160728,1468	SLC17A5,SLC5A5,SLC5A8,SLC25A10
5416963	Axon guidance	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	51332,57731,6710,5362	SPTBN5,SPTBN4,SPTB,PLXNA2
REACT_2122	ChREBP activates metabolic gene expression	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	6945,5313,47,2194	MLX,PKLR,ACLY,FASN
REACT_1815	Recycling of eIF2:GDP	0.50276565339717	-0.687631115265256	8	4	0.00126462219411951	3163	7167	8892,8890,8891,1968	EIF2B2,EIF2B4,EIF2B3,EIF2S3
REACT_163936	Fc epsilon receptor (FCERI) signaling	0.505795526736245	-0.681622788723212	194	86	0.0271893771735694	3163	7167	685,7189,1839,2207,7249,942,2475,5894,387522,2064,9542,1026,3937,4067,7409,5154,6464,4790,3551,5336,5296,5290,8503,3815,5159,64223,27040,2931,207,2249,4773,3710,4772,983,2260,2246,8517,5335,2534,10718,23118,4254,2932,3084,27327,57690,27161,7410,79109,23239,3725,2261,4775,117145,5601,5781,2205,2065,1385,6885,646626,6850,6199,5170,5058,2264,10451,2254,5609,3164,27006,5295,10892,3845,2353,5605,1956,2248,57761,10000,26281,4792,8817,3708,3265,940	BTC,TRAF6,HBEGF,FCER1G,TSC2,CD86,MTOR,RAF1,TMEM189-UBE2V1,ERBB2,NRG2,CDKN1A,LCP2,LYN,VAV1,PDGFA,SHC1,NFKB1,IKBKB,PLCG2,PIK3R2,PIK3CA,PIK3R3,KIT,PDGFRB,MLST8,LAT,GSK3A,AKT1,FGF4,NFATC2,ITPR3,NFATC1,CDK1,FGFR1,FGF1,IKBKG,PLCG1,FYN,NRG3,TAB2,KITLG,GSK3B,NRG1,TNRC6A,TNRC6C,AGO2,VAV2,MAPKAP1,PHLPP1,JUN,FGFR3,NFATC3,THEM4,MAPK9,PTPN11,FCER1A,ERBB3,CREB1,MAP3K7,LOC646626,SYK,RPS6KB2,PDPK1,PAK1,FGFR4,VAV3,FGF9,MAP2K7,NR4A1,FGF22,PIK3R1,MALT1,KRAS,FOS,MAP2K2,EGFR,FGF3,TRIB3,AKT3,FGF20,NFKBIA,FGF18,ITPR1,HRAS,CD28
REACT_75918	Inwardly rectifying K+ channels	0.506172509811356	-0.680877739316641	33	15	0.00474233322794815	3163	7167	6833,3762,3768,3765,3759,2793,9568,2788,3763,2786,2782,3767,3766,2783,548645	ABCC8,KCNJ5,KCNJ12,KCNJ9,KCNJ2,GNGT2,GABBR2,GNG7,KCNJ6,GNG4,GNB1,KCNJ11,KCNJ10,GNB2,DNAJC25
REACT_1520	Gluconeogenesis	0.506172509811356	-0.680877739316641	33	15	0.00474233322794815	3163	7167	2597,5091,5230,10165,226,1468,5105,8402,2805,5224,2821,2023,5566,5567,6576	GAPDH,PC,PGK1,SLC25A13,ALDOA,SLC25A10,PCK1,SLC25A11,GOT1,PGAM2,GPI,ENO1,PRKACA,PRKACB,SLC25A1
REACT_121256	Phagosomal maturation (early endosomal stage)	0.506172509811356	-0.680877739316641	33	15	0.00474233322794815	3163	7167	533,4689,10312,127124,90423,527,820,528,51606,4843,4688,8992,9114,525,9550	ATP6V0B,NCF4,TCIRG1,ATP6V1G3,ATP6V1E2,ATP6V0C,CAMP,ATP6V1C1,ATP6V1H,NOS2,NCF2,ATP6V0E1,ATP6V0D1,ATP6V1B1,ATP6V1G1
REACT_121288	Keratan sulfate/keratin metabolism	0.506172509811356	-0.680877739316641	33	15	0.00474233322794815	3163	7167	93010,6484,2331,4166,8534,176,2683,6483,8703,8702,10402,6482,6487,5549,10331	B3GNT7,ST3GAL4,FMOD,CHST6,CHST1,ACAN,B4GALT1,ST3GAL2,B4GALT3,B4GALT4,ST3GAL6,ST3GAL1,ST3GAL3,PRELP,B3GNT3
REACT_121237	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.506172509811356	-0.680877739316641	33	15	0.00474233322794815	3163	7167	533,4689,10312,127124,90423,527,820,528,51606,4843,4688,8992,9114,525,9550	ATP6V0B,NCF4,TCIRG1,ATP6V1G3,ATP6V1E2,ATP6V0C,CAMP,ATP6V1C1,ATP6V1H,NOS2,NCF2,ATP6V0E1,ATP6V0D1,ATP6V1B1,ATP6V1G1
REACT_172581	PCP/CE pathway	0.506994588256003	-0.679254949499198	92	41	0.0129623774897249	3163	7167	5689,5684,5721,8325,5578,5881,23002,9491,8323,161,5880,5696,5687,5216,5701,10213,1212,1856,5686,8321,7311,5692,144165,7481,23513,5710,57216,5685,7316,5704,5699,54361,122706,5714,5709,160,81029,1211,1855,7855,10197	PSMB1,PSMA3,PSME2,FZD8,PRKCA,RAC3,DAAM1,PSMF1,FZD6,AP2A2,RAC2,PSMB8,PSMA6,PFN1,PSMC2,PSMD14,CLTB,DVL2,PSMA5,FZD1,UBA52,PSMB4,PRICKLE1,WNT11,SCRIB,PSMD4,VANGL2,PSMA4,UBC,PSMC4,PSMB10,WNT4,PSMB11,PSMD8,PSMD3,AP2A1,WNT5B,CLTA,DVL1,FZD5,PSME3
REACT_15306	Cytosolic tRNA aminoacylation	0.511789814591609	-0.66984125660413	24	11	0.00347771103382864	3163	7167	833,2058,5917,51520,4677,1615,7407,10056,7965,9521,6897	CARS,EPRS,RARS,LARS,NARS,DARS,VARS,FARSB,AIMP2,EEF1E1,TARS
REACT_602	Lipid digestion, mobilization, and transport	0.512139932468266	-0.669157385681719	49	22	0.00695542206765729	3163	7167	4547,3339,29881,3949,336,1056,857,3990,6382,5566,51099,51128,3931,4018,5034,1208,81693,649,949,5499,5567,9619	MTTP,HSPG2,NPC1L1,LDLR,APOA2,CEL,CAV1,LIPC,SDC1,PRKACA,ABHD5,SAR1B,LCAT,LPA,P4HB,CLPS,AMN,BMP1,SCARB1,PPP1CA,PRKACB,ABCG1
REACT_116022	Nuclear signaling by ERBB4	0.516974598218879	-0.659761538719693	40	18	0.00569079987353778	3163	7167	685,6868,1839,9978,51107,9542,2688,10718,51741,23118,5618,5781,5664,6500,6776,3084,3717,8945	BTC,ADAM17,HBEGF,RBX1,APH1A,NRG2,GH1,NRG3,WWOX,TAB2,PRLR,PTPN11,PSEN2,SKP1,STAT5A,NRG1,JAK2,BTRC
REACT_1590	G1 Phase	0.516974598218879	-0.659761538719693	40	18	0.00569079987353778	3163	7167	28227,7311,902,1019,1871,1026,7316,595,5515,5518,5933,896,7027,1163,6500,7029,1032,1870	PPP2R3B,UBA52,CCNH,CDK4,E2F3,CDKN1A,UBC,CCND1,PPP2CA,PPP2R1A,RBL1,CCND3,TFDP1,CKS1B,SKP1,TFDP2,CDKN2D,E2F2
REACT_821	Cyclin D associated events in G1	0.516974598218879	-0.659761538719693	40	18	0.00569079987353778	3163	7167	28227,7311,902,1019,1871,1026,7316,595,5515,5518,5933,896,7027,1163,6500,7029,1032,1870	PPP2R3B,UBA52,CCNH,CDK4,E2F3,CDKN1A,UBC,CCND1,PPP2CA,PPP2R1A,RBL1,CCND3,TFDP1,CKS1B,SKP1,TFDP2,CDKN2D,E2F2
REACT_1473	Mitochondrial Fatty Acid Beta-Oxidation	0.520595194094314	-0.652782517938899	15	7	0.00221308883970914	3163	7167	35,5096,1666,3033,4594,37,166785	ACADS,PCCB,DECR1,HADH,MUT,ACADVL,MMAA
REACT_12579	SHC1 events in EGFR signaling	0.520595194094314	-0.652782517938899	15	7	0.00221308883970914	3163	7167	3845,6464,983,3265,5894,5605,1956	KRAS,SHC1,CDK1,HRAS,RAF1,MAP2K2,EGFR
REACT_1385	Processive synthesis on the lagging strand	0.520595194094314	-0.652782517938899	15	7	0.00221308883970914	3163	7167	3978,6118,5111,5558,5424,57804,5425	LIG1,RPA2,PCNA,PRIM2,POLD1,POLD4,POLD2
REACT_12077	Signalling to p38 via RIT and RIN	0.520595194094314	-0.652782517938899	15	7	0.00221308883970914	3163	7167	3845,6016,983,3265,5894,5605,4914	KRAS,RIT1,CDK1,HRAS,RAF1,MAP2K2,NTRK1
REACT_508	Signal attenuation	0.520595194094314	-0.652782517938899	15	7	0.00221308883970914	3163	7167	2887,3643,6464,723961,53358,25759,3630	GRB10,INSR,SHC1,INS-IGF2,SHC3,SHC2,INS
REACT_1095	Activation of the pre-replicative complex	0.523281130432296	-0.647636425049644	31	14	0.00442617767941827	3163	7167	4173,6118,55388,4999,5426,5558,4174,81620,10926,84515,29935,990,4171,4172	MCM4,RPA2,MCM10,ORC2,POLE,PRIM2,MCM5,CDT1,DBF4,MCM8,RPA4,CDC6,MCM2,MCM3
REACT_13796	Amino acid transport across the plasma membrane	0.523281130432296	-0.647636425049644	31	14	0.00442617767941827	3163	7167	6533,6509,348932,81539,206358,11136,8140,55117,56301,340024,10991,124935,23428,9057	SLC6A6,SLC1A4,SLC6A18,SLC38A1,SLC36A1,SLC7A9,SLC7A5,SLC6A15,SLC7A10,SLC6A19,SLC38A3,SLC43A2,SLC7A8,SLC7A6
REACT_2014	Synthesis of DNA	0.523766978959667	-0.646708390209826	97	43	0.0135946885867847	3163	7167	5689,5684,5721,81620,3978,1026,5424,9491,4173,6118,5687,5111,5696,4174,5701,51343,10213,57804,5686,9837,7311,5983,4999,5692,5558,990,4171,5710,5685,84296,7316,5704,5699,122706,51659,5426,5709,5714,84515,5981,10197,5425,4172	PSMB1,PSMA3,PSME2,CDT1,LIG1,CDKN1A,POLD1,PSMF1,MCM4,RPA2,PSMA6,PCNA,PSMB8,MCM5,PSMC2,FZR1,PSMD14,POLD4,PSMA5,GINS1,UBA52,RFC3,ORC2,PSMB4,PRIM2,CDC6,MCM2,PSMD4,PSMA4,GINS4,UBC,PSMC4,PSMB10,PSMB11,GINS2,POLE,PSMD3,PSMD8,MCM8,RFC1,PSME3,POLD2,MCM3
REACT_19145	G beta:gamma signalling through PLC beta	0.532337253539576	-0.63047805526778	22	10	0.00316155548529877	3163	7167	2793,59345,2788,2786,2782,51764,5330,548645,2783,5331	GNGT2,GNB4,GNG7,GNG4,GNB1,GNG13,PLCB2,DNAJC25,GNB2,PLCB3
REACT_7961	Telomere C-strand (Lagging Strand) Synthesis	0.532337253539576	-0.63047805526778	22	10	0.00316155548529877	3163	7167	6118,5983,5111,5426,5558,3978,5981,5424,57804,5425	RPA2,RFC3,PCNA,POLE,PRIM2,LIG1,RFC1,POLD1,POLD4,POLD2
REACT_6769	Activation of ATR in response to replication stress	0.532689993589515	-0.629815649561657	38	17	0.0053746443250079	3163	7167	993,55388,4999,5983,63967,10926,1111,990,4171,995,3364,6118,4173,4174,84515,545,4172	CDC25A,MCM10,ORC2,RFC3,CLSPN,DBF4,CHEK1,CDC6,MCM2,CDC25C,HUS1,RPA2,MCM4,MCM5,MCM8,ATR,MCM3
REACT_11038	Pregnenolone biosynthesis	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	1583,80765,134429	CYP11A1,STARD5,STARD4
REACT_75881	Methionine salvage pathway	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	58478,2805,55256	ENOPH1,GOT1,ADI1
REACT_150422	Synthesis of 15-eicosatetraenoic acid derivatives	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	5743,2876,2879	PTGS2,GPX1,GPX4
REACT_21376	Pyrimidine biosynthesis	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	790,1723,1635	CAD,DHODH,DCTD
5471179	Signaling by Robo receptor	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	23380,9901,57522	SRGAP2,SRGAP3,SRGAP1
REACT_20510	RSK activation	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	5170,6196,6195	PDPK1,RPS6KA2,RPS6KA1
5470601	Developmental Biology	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	23380,9901,57522	SRGAP2,SRGAP3,SRGAP1
REACT_402	TRAIL  signaling	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	8743,8772,8837	TNFSF10,FADD,CFLAR
5471178	Inactivation of Cdc42 and Rac	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	23380,9901,57522	SRGAP2,SRGAP3,SRGAP1
REACT_570	IRS activation	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	3643,723961,3630	INSR,INS-IGF2,INS
5470600	Axon guidance	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	23380,9901,57522	SRGAP2,SRGAP3,SRGAP1
REACT_9416	FGFR2b ligand binding and activation	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	2246,27006,2248	FGF1,FGF22,FGF3
REACT_11064	Activation of TRKA receptors	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	4915,117,4914	NTRK2,ADCYAP1R1,NTRK1
REACT_6840	Transport and synthesis of PAPS	0.540909677132552	-0.614502969466953	6	3	0.00094846664558963	3163	7167	10861,1836,9061	SLC26A1,SLC26A2,PAPSS1
REACT_16907	Association of TriC/CCT with target proteins during biosynthesis	0.541509403508498	-0.61339484702521	29	13	0.0041100221308884	3163	7167	22948,26234,10576,11328,26272,8877,7203,63971,55294,10574,26270,26985,54461	CCT5,FBXL5,CCT2,FKBP9,FBXO4,SPHK1,CCT3,KIF13A,FBXW7,CCT7,FBXO6,AP3M1,FBXW5
REACT_21374	SHC-mediated cascade	0.541509403508498	-0.61339484702521	29	13	0.0041100221308884	3163	7167	2246,2264,2254,2261,6464,2249,27006,26281,8817,3845,3265,2260,2248	FGF1,FGFR4,FGF9,FGFR3,SHC1,FGF4,FGF22,FGF20,FGF18,KRAS,HRAS,FGFR1,FGF3
REACT_6185	HIV Infection	0.542394038790874	-0.611762532846151	225	99	0.0312993993044578	3163	7167	920,10015,5684,5721,4869,1794,161,10053,5696,5687,23225,2968,653653,55746,919,5701,8907,10213,81929,25920,6881,7311,902,6923,5441,9978,8905,6924,9525,8021,51160,2534,6827,29082,122706,7514,291,904,5714,5709,7251,6500,5437,128866,27183,8086,4836,9150,5689,5440,6908,3978,567,375,9491,129401,3105,11097,8178,2961,5902,51606,130340,79902,3837,5686,2967,5438,5692,79643,5045,5905,6921,55048,7469,51652,5710,5685,7316,5704,7520,7175,5699,155382,5439,2957,1104,160,1025,6874,5434,9688,22916,3159,10197,91782,940,8945,1234	CD4,PDCD6IP,PSMA3,PSME2,NPM1,DOCK2,AP2A2,AP1M2,PSMB8,PSMA6,NUP210,GTF2H4,LOC653653,NUP133,CD247,PSMC2,AP1M1,PSMD14,SEH1L,NELFB,TAF10,UBA52,CCNH,TCEB2,POLR2L,RBX1,AP1S2,TCEB3,VPS4B,NUP214,VPS28,FYN,SUPT4H1,CHMP4A,PSMB11,XPO1,SLC25A4,CCNT1,PSMD8,PSMD3,TSG101,SKP1,POLR2H,CHMP4B,VPS4A,AAAS,NMT1,CTDP1,PSMB1,POLR2K,TBP,LIG1,B2M,ARF1,PSMF1,NUP35,HLA-A,NUPL2,ELL,GTF2E2,RANBP1,ATP6V1H,AP1S3,NUP85,KPNB1,PSMA5,GTF2H3,POLR2I,PSMB4,CHMP6,FURIN,RANGAP1,TCEB1,VPS37C,NELFA,CHMP3,PSMD4,PSMA4,UBC,PSMC4,XRCC5,TPR,PSMB10,VPS37D,POLR2J,GTF2A1,RCC1,AP2A1,CDK9,TAF4,POLR2E,NUP93,NCBP2,HMGA1,PSME3,CHMP7,CD28,BTRC,CCR5
REACT_9031	Vpu mediated degradation of CD4	0.547879154628312	-0.601700537103652	52	23	0.00727157761618716	3163	7167	5689,920,7311,5684,5692,5721,5710,5685,9491,7316,5704,5699,5687,122706,5696,5714,5709,5701,10213,6500,10197,5686,8945	PSMB1,CD4,UBA52,PSMA3,PSMB4,PSME2,PSMD4,PSMA4,PSMF1,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,SKP1,PSME3,PSMA5,BTRC
REACT_2243	Assembly of the pre-replicative complex	0.547920088356283	-0.601625826834867	68	30	0.0094846664558963	3163	7167	5689,4999,7311,5684,5692,5721,81620,1871,990,5710,4171,9491,5685,7316,5704,4173,5699,5687,5696,122706,5709,5714,4174,5701,84515,10213,10197,1870,5686,4172	PSMB1,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,E2F3,CDC6,PSMD4,MCM2,PSMF1,PSMA4,UBC,PSMC4,MCM4,PSMB10,PSMA6,PSMB8,PSMB11,PSMD3,PSMD8,MCM5,PSMC2,MCM8,PSMD14,PSME3,E2F2,PSMA5,MCM3
REACT_25195	Advanced glycosylation endproduct receptor signaling	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	3146,830,1650,5589,351,6283	HMGB1,CAPZA2,DDOST,PRKCSH,APP,S100A12
REACT_13462	Activation of DNA fragmentation factor	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	3148,3146,1677,3005,3837,3006	HMGB2,HMGB1,DFFB,H1F0,KPNB1,HIST1H1C
REACT_150238	Signaling by Activin	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	4088,8928,4087,3625,4089,10272	SMAD3,FOXH1,SMAD2,INHBB,SMAD4,FSTL3
REACT_12564	AKT phosphorylates targets in the cytosol	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	2932,1026,2931,207,7249,10000	GSK3B,CDKN1A,GSK3A,AKT1,TSC2,AKT3
REACT_1213	Apoptosis induced DNA fragmentation	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	3148,3146,1677,3005,3837,3006	HMGB2,HMGB1,DFFB,H1F0,KPNB1,HIST1H1C
REACT_9452	FGFR4 ligand binding and activation	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	2246,2264,2254,2249,26281,8817	FGF1,FGFR4,FGF9,FGF4,FGF20,FGF18
REACT_121036	The activation of arylsulfatases	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	285362,79642,411,153642,340075,410	SUMF1,ARSJ,ARSB,ARSK,ARSI,ARSA
REACT_12435	Retrograde neurotrophin signalling	0.548010445784763	-0.601460930564765	13	6	0.00189693329117926	3163	7167	1211,161,26052,160,4914,1785	CLTA,AP2A2,DNM3,AP2A1,NTRK1,DNM2
REACT_723	Glucose metabolism	0.553933046286978	-0.590711454616074	75	33	0.0104331331014859	3163	7167	2632,7360,5313,10165,5566,5518,5211,1468,5105,2997,2805,2023,5261,5567,6576,5210,5236,2597,7311,5208,5257,5209,5315,7316,5834,5515,5091,5230,226,5224,8402,2821,5528	GBE1,UGP2,PKLR,SLC25A13,PRKACA,PPP2R1A,PFKL,SLC25A10,PCK1,GYS1,GOT1,ENO1,PHKG2,PRKACB,SLC25A1,PFKFB4,PGM1,GAPDH,UBA52,PFKFB2,PHKB,PFKFB3,PKM,UBC,PYGB,PPP2CA,PC,PGK1,ALDOA,PGAM2,SLC25A11,GPI,PPP2R5D
REACT_312	Lagging Strand Synthesis	0.554815240457242	-0.589120120736276	20	9	0.00284539993676889	3163	7167	6118,5111,5983,5558,3978,5981,57804,5424,5425	RPA2,PCNA,RFC3,PRIM2,LIG1,RFC1,POLD4,POLD1,POLD2
REACT_12005	Prolonged ERK activation events	0.554815240457242	-0.589120120736276	20	9	0.00284539993676889	3163	7167	1399,5335,2889,5894,4914,3845,5605,3265,983	CRKL,PLCG1,RAPGEF1,RAF1,NTRK1,KRAS,MAP2K2,HRAS,CDK1
REACT_150420	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.554815240457242	-0.589120120736276	20	9	0.00284539993676889	3163	7167	9261,240,2678,4056,57834,1800,22949,2687,4048	MAPKAPK2,ALOX5,GGT1,LTC4S,CYP4F11,DPEP1,PTGR1,GGT5,LTA4H
REACT_75770	Voltage gated Potassium channels	0.555984479588237	-0.587014899530815	43	19	0.00600695542206766	3163	7167	27012,9196,3786,3754,3746,3752,3784,26251,3757,3749,3756,3785,3737,170850,7881,3755,3788,3739,8514	KCNV1,KCNAB3,KCNQ3,KCNF1,KCNC1,KCND3,KCNQ1,KCNG2,KCNH2,KCNC4,KCNH1,KCNQ2,KCNA2,KCNG3,KCNAB1,KCNG1,KCNS2,KCNA4,KCNAB2
REACT_19290	G beta:gamma signalling through PI3Kgamma	0.560997638205081	-0.578038583441421	27	12	0.00379386658235852	3163	7167	5170,207,23533,2793,59345,10000,2788,2786,2782,51764,2783,548645	PDPK1,AKT1,PIK3R5,GNGT2,GNB4,AKT3,GNG7,GNG4,GNB1,GNG13,GNB2,DNAJC25
REACT_15334	DARPP-32 events	0.560997638205081	-0.578038583441421	27	12	0.00379386658235852	3163	7167	1020,5515,5518,5575,5577,5533,5499,5144,5566,5143,5528,5567	CDK5,PPP2CA,PPP2R1A,PRKAR1B,PRKAR2B,PPP3CC,PPP1CA,PDE4D,PRKACA,PDE4C,PPP2R5D,PRKACB
REACT_13565	Regulation of ornithine decarboxylase (ODC)	0.562061091545848	-0.576144731178044	50	22	0.00695542206765729	3163	7167	5689,5684,5692,1728,5721,51686,5710,4953,5685,9491,5704,5699,5687,122706,5696,5714,5709,5701,10213,51582,10197,5686	PSMB1,PSMA3,PSMB4,NQO1,PSME2,OAZ3,PSMD4,ODC1,PSMA4,PSMF1,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,AZIN1,PSME3,PSMA5
REACT_6761	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.565620577852529	-0.569831782719783	73	32	0.0101169775529561	3163	7167	5689,51433,7311,5684,5692,5721,991,5710,8697,9491,5685,7324,7316,5704,64682,5699,5687,5696,122706,8881,996,5709,5714,5701,51343,10393,10213,51434,10197,11065,5686,29945	PSMB1,ANAPC5,UBA52,PSMA3,PSMB4,PSME2,CDC20,PSMD4,CDC23,PSMF1,PSMA4,UBE2E1,UBC,PSMC4,ANAPC1,PSMB10,PSMA6,PSMB8,PSMB11,CDC16,CDC27,PSMD3,PSMD8,PSMC2,FZR1,ANAPC10,PSMD14,ANAPC7,PSME3,UBE2C,PSMA5,ANAPC4
REACT_682	Mitotic Prometaphase	0.569254887762929	-0.563426987754677	112	49	0.015491621877964	3163	7167	6396,22919,1063,83540,11004,11243,54908,891,91687,55920,25909,5518,55746,23047,8379,699,79019,79902,81929,10726,11130,1058,1060,9184,10274,632,991,5905,6232,701,10592,983,79682,5515,3796,5529,7514,25936,79980,5525,113130,8243,147841,80152,54820,151648,3619,5528,5885	SEC13,MAPRE1,CENPF,NUF2,KIF2C,PMF1,SPDL1,CCNB1,CENPL,RCC2,AHCTF1,PPP2R1A,NUP133,PDS5B,MAD1L1,BUB1,CENPM,NUP85,SEH1L,NUDC,ZWINT,CENPA,CENPC,BUB3,STAG1,BGLAP,CDC20,RANGAP1,RPS27,BUB1B,SMC2,CDK1,CENPU,PPP2CA,KIF2A,PPP2R5E,XPO1,NSL1,DSN1,PPP2R5A,CDCA5,SMC1A,SPC24,CENPT,NDE1,SGOL1,INCENP,PPP2R5D,RAD21
REACT_25359	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.570703427497026	-0.560885595680348	80	35	0.0110654441985457	3163	7167	7323,3146,7189,1540,79671,7186,1660,8737,3661,351,79132,7706,5300,10010,4790,3551,57506,4791,7311,29110,7128,54941,9140,6283,7316,8772,8517,9641,4792,7322,84166,7187,3665,9474,3659	UBE2D3,HMGB1,TRAF6,CYLD,NLRX1,TRAF2,DHX9,RIPK1,IRF3,APP,DHX58,TRIM25,PIN1,TANK,NFKB1,IKBKB,MAVS,NFKB2,UBA52,TBK1,TNFAIP3,RNF125,ATG12,S100A12,UBC,FADD,IKBKG,IKBKE,NFKBIA,UBE2D2,NLRC5,TRAF3,IRF7,ATG5,IRF1
REACT_6913	Cytosolic sulfonation of small molecules	0.579606408740635	-0.545406011418281	18	8	0.00252924438823901	3163	7167	10861,10380,1836,445329,6820,9061,6818,25830	SLC26A1,BPNT1,SLC26A2,SULT1A4,SULT2B1,PAPSS1,SULT1A3,SULT4A1
REACT_111080	Spry regulation of FGF signaling	0.579606408740635	-0.545406011418281	18	8	0.00252924438823901	3163	7167	5515,7311,867,5518,10253,6714,7316,5781	PPP2CA,UBA52,CBL,PPP2R1A,SPRY2,SRC,UBC,PTPN11
REACT_150139	SHC-related events triggered by IGF1R	0.579606408740635	-0.545406011418281	18	8	0.00252924438823901	3163	7167	3845,6464,53358,983,3265,5894,5605,25759	KRAS,SHC1,SHC3,CDK1,HRAS,RAF1,MAP2K2,SHC2
REACT_2086	Purine catabolism	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	847,30833,4860,2876,4907	CAT,NT5C,PNP,GPX1,NT5E
REACT_25380	IRAK2 mediated activation of TAK1 complex	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	7189,7311,6885,23118,7316	TRAF6,UBA52,MAP3K7,TAB2,UBC
REACT_1707	CDC6 association with the ORC:origin complex	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	990,4999,1870,84515,1871	CDC6,ORC2,E2F2,MCM8,E2F3
REACT_121153	Signaling by activated point mutants of FGFR1	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	2246,2254,2249,26281,2260	FGF1,FGF9,FGF4,FGF20,FGFR1
REACT_6960	Glutathione synthesis and recycling	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	2678,26873,2687,55748,79017	GGT1,OPLAH,GGT5,CNDP2,GGCT
REACT_9465	Heme biosynthesis	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	3145,7390,210,5498,1352	HMBS,UROS,ALAD,PPOX,COX10
REACT_9515	FGFR1c ligand binding and activation	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	2246,2254,2249,26281,2260	FGF1,FGF9,FGF4,FGF20,FGFR1
REACT_25018	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.58001094596067	-0.544708303273769	11	5	0.00158077774264938	3163	7167	7189,7311,6885,23118,7316	TRAF6,UBA52,MAP3K7,TAB2,UBC
REACT_20647	Thromboxane signalling through TP receptor	0.581913600750095	-0.54143329459026	25	11	0.00347771103382864	3163	7167	2769,2793,59345,2788,2786,2782,51764,2783,2767,548645,9630	GNA15,GNGT2,GNB4,GNG7,GNG4,GNB1,GNG13,GNB2,GNA11,DNAJC25,GNA14
REACT_118713	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.581913600750095	-0.54143329459026	25	11	0.00347771103382864	3163	7167	80205,85441,860,8850,79718,6256,7004,6907,96764,10499,10498	CHD9,HELZ2,RUNX2,KAT2B,TBL1XR1,RXRA,TEAD4,TBL1X,TGS1,NCOA2,CARM1
REACT_6190	Rev-mediated nuclear export of HIV RNA	0.585061916865029	-0.536037596556101	32	14	0.00442617767941827	3163	7167	11097,7175,23225,7514,1104,55746,5902,9688,5905,8021,79902,81929,8086,129401	NUPL2,TPR,NUP210,XPO1,RCC1,NUP133,RANBP1,NUP93,RANGAP1,NUP214,NUP85,SEH1L,AAAS,NUP35
REACT_169325	Oncogene Induced Senescence	0.585061916865029	-0.536037596556101	32	14	0.00442617767941827	3163	7167	57690,7311,3397,2114,2077,1019,7027,1871,2113,1870,1032,7316,27327,6667	TNRC6C,UBA52,ID1,ETS2,ERF,CDK4,TFDP1,E2F3,ETS1,E2F2,CDKN2D,UBC,TNRC6A,SP1
REACT_2254	G1/S DNA Damage Checkpoints	0.585701065909443	-0.534945745998278	62	27	0.00853619981030667	3163	7167	9134,993,5689,7311,5684,5692,5721,1111,1026,5710,9491,898,5685,7316,5704,64326,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CCNE2,CDC25A,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CHEK1,CDKN1A,PSMD4,PSMF1,CCNE1,PSMA4,UBC,PSMC4,RFWD2,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_829	Regulation of DNA replication	0.593784065197881	-0.5212395523142	76	33	0.0104331331014859	3163	7167	5689,55388,4999,7311,5684,5692,5721,81620,1871,990,1026,5710,4171,9491,5685,7316,5704,4173,5699,5687,5696,122706,5709,5714,4174,5701,51343,84515,10213,10197,1870,5686,4172	PSMB1,MCM10,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,E2F3,CDC6,CDKN1A,PSMD4,MCM2,PSMF1,PSMA4,UBC,PSMC4,MCM4,PSMB10,PSMA6,PSMB8,PSMB11,PSMD3,PSMD8,MCM5,PSMC2,FZR1,MCM8,PSMD14,PSME3,E2F2,PSMA5,MCM3
REACT_150275	Synthesis of IPs in the nucleus	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	64768,9807	IPPK,IP6K1
REACT_1875	Amine Oxidase reactions	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	4128,54498	MAOA,SMOX
REACT_18288	Adenosine P1 receptors	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	136,134	ADORA2B,ADORA1
REACT_308	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	9134,898	CCNE2,CCNE1
REACT_701	Activation, myristolyation of BID and translocation to mitochondria	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	4836,637	NMT1,BID
REACT_1757	mRNA Editing	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	104,103	ADARB1,ADAR
REACT_20515	Proton-coupled monocarboxylate transport	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	9123,23539	SLC16A3,SLC16A8
REACT_13594	Neurotransmitter uptake and Metabolism In Glial Cells	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	81539,2752	SLC38A1,GLUL
REACT_1407	Plasmalogen biosynthesis	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	84188,8443	FAR1,GNPAT
REACT_13655	AKT-mediated inactivation of FOXO1A	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	207,10000	AKT1,AKT3
REACT_13639	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	81539,2752	SLC38A1,GLUL
REACT_19281	Class II GLUTs	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	56606,155184	SLC2A9,SLC2A7
REACT_121117	Abnormal metabolism in phenylketonuria	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	883,3945	CCBL1,LDHB
REACT_150276	Antagonism of Activin by Follistatin	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	3625,10272	INHBB,FSTL3
REACT_8001	Alternative complement activation	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	718,1675	C3,CFD
REACT_20617	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	5829,3688	PXN,ITGB1
REACT_75870	Classical Kir channels	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	3768,3759	KCNJ12,KCNJ2
REACT_75775	ATP sensitive Potassium channels	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	6833,3767	ABCC8,KCNJ11
REACT_11062	NGF processing	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	5045,5046	FURIN,PCSK6
REACT_121301	Hyaluronan biosynthesis and export	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	3038,3037	HAS3,HAS2
REACT_13779	Axonal growth stimulation	0.594805776815061	-0.51952035224582	4	2	0.000632311097059753	3163	7167	4804,396	NGFR,ARHGDIA
REACT_1208	p53-Independent G1/S DNA damage checkpoint	0.595525532025506	-0.518311016168008	53	23	0.00727157761618716	3163	7167	993,5689,7311,5684,5692,5721,1111,5710,9491,5685,7316,5704,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CDC25A,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CHEK1,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_1614	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	0.595525532025506	-0.518311016168008	53	23	0.00727157761618716	3163	7167	993,5689,7311,5684,5692,5721,1111,5710,9491,5685,7316,5704,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CDC25A,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CHEK1,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_2160	p53-Independent DNA Damage Response	0.595525532025506	-0.518311016168008	53	23	0.00727157761618716	3163	7167	993,5689,7311,5684,5692,5721,1111,5710,9491,5685,7316,5704,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CDC25A,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CHEK1,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_12034	Signaling by BMP	0.604459743544685	-0.503420205777259	23	10	0.00316155548529877	3163	7167	650,7323,9241,4092,4090,64388,657,4091,4089,6497	BMP2,UBE2D3,NOG,SMAD7,SMAD5,GREM2,BMPR1A,SMAD6,SMAD4,SKI
REACT_9396	FGFR ligand binding and activation	0.604459743544685	-0.503420205777259	23	10	0.00316155548529877	3163	7167	2246,2264,2254,2261,2249,27006,26281,8817,2260,2248	FGF1,FGFR4,FGF9,FGFR3,FGF4,FGF22,FGF20,FGF18,FGFR1,FGF3
REACT_2054	Double-Strand Break Repair	0.604459743544685	-0.503420205777259	23	10	0.00316155548529877	3163	7167	3978,472,6118,5893,672,9656,7158,5591,10111,7520	LIG1,ATM,RPA2,RAD52,BRCA1,MDC1,TP53BP1,PRKDC,RAD50,XRCC5
REACT_18347	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.604547064430898	-0.503275755165751	30	13	0.0041100221308884	3163	7167	161,2890,817,27092,2036,816,160,80852,1739,5578,818,815,10369	AP2A2,GRIA1,CAMK2D,CACNG4,EPB41L1,CAMK2B,AP2A1,GRIP2,DLG1,PRKCA,CAMK2G,CAMK2A,CACNG2
REACT_18307	Trafficking of AMPA receptors	0.604547064430898	-0.503275755165751	30	13	0.0041100221308884	3163	7167	161,2890,817,27092,2036,816,160,80852,1739,5578,818,815,10369	AP2A2,GRIA1,CAMK2D,CACNG4,EPB41L1,CAMK2B,AP2A1,GRIP2,DLG1,PRKCA,CAMK2G,CAMK2A,CACNG2
REACT_18312	NCAM1 interactions	0.605884485642139	-0.501065928834942	37	16	0.00505848877647803	3163	7167	1299,1292,1284,375790,1291,64096,8912,2668,6900,784,779,4902,8911,1298,1293,2675	COL9A3,COL6A2,COL4A2,AGRN,COL6A1,GFRA4,CACNA1H,GDNF,CNTN2,CACNB3,CACNA1S,NRTN,CACNA1I,COL9A2,COL6A3,GFRA2
REACT_15480	ABC-family proteins mediated transport	0.605884485642139	-0.501065928834942	37	16	0.00505848877647803	3163	7167	5824,10058,10257,340273,1244,23456,10351,10347,6833,5825,368,20,11194,215,8714,9619	PEX19,ABCB6,ABCC4,ABCB5,ABCC2,ABCB10,ABCA8,ABCA7,ABCC8,ABCD3,ABCC6,ABCA2,ABCB8,ABCD1,ABCC3,ABCG1
REACT_13812	Endogenous sterols	0.607217652377349	-0.498867981555589	16	7	0.00221308883970914	3163	7167	1588,1584,1583,1589,5740,10858,1585	CYP19A1,CYP11B1,CYP11A1,CYP21A2,PTGIS,CYP46A1,CYP11B2
REACT_1181	Association of licensing factors with the pre-replicative complex	0.607217652377349	-0.498867981555589	16	7	0.00221308883970914	3163	7167	990,4999,7311,1870,81620,7316,1871	CDC6,ORC2,UBA52,E2F2,CDT1,UBC,E2F3
REACT_13643	NRIF signals cell death from the nucleus	0.607217652377349	-0.498867981555589	16	7	0.00221308883970914	3163	7167	7189,7311,8878,4804,51107,7316,5664	TRAF6,UBA52,SQSTM1,NGFR,APH1A,UBC,PSEN2
REACT_1366	RNA Polymerase II Transcription	0.608120025629658	-0.497383005923779	104	45	0.0142269996838445	3163	7167	9150,6908,5440,134353,6431,10250,9939,10978,4799,6635,10914,8178,2961,29894,6427,10189,2968,25920,1477,6881,2967,5438,902,5441,6923,6628,6924,10921,6921,51585,7469,6426,6827,5439,2957,904,1025,6874,5434,1478,22916,5437,8106,79869,9785	CTDP1,TBP,POLR2K,LSM11,SRSF6,SRRM1,RBM8A,CLP1,NFX1,SNRPE,PAPOLA,ELL,GTF2E2,CPSF1,SRSF2,ALYREF,GTF2H4,NELFB,CSTF1,TAF10,GTF2H3,POLR2I,CCNH,POLR2L,TCEB2,SNRPB,TCEB3,RNPS1,TCEB1,PCF11,NELFA,SRSF1,SUPT4H1,POLR2J,GTF2A1,CCNT1,CDK9,TAF4,POLR2E,CSTF2,NCBP2,POLR2H,PABPN1,CPSF7,DHX38
REACT_6361	Late Phase of HIV Life Cycle	0.608698806527183	-0.496431704175518	127	55	0.0173885551691432	3163	7167	4836,9150,10015,6908,5440,129401,11097,8178,2961,23225,2968,55746,5902,79902,81929,25920,6881,2967,5438,7311,902,6923,5441,79643,5045,6924,9525,5905,6921,55048,7469,51652,8021,7316,7175,51160,155382,7514,29082,6827,2957,5439,904,1104,1025,6874,5434,9688,7251,22916,5437,128866,27183,91782,8086	NMT1,CTDP1,PDCD6IP,TBP,POLR2K,NUP35,NUPL2,ELL,GTF2E2,NUP210,GTF2H4,NUP133,RANBP1,NUP85,SEH1L,NELFB,TAF10,GTF2H3,POLR2I,UBA52,CCNH,TCEB2,POLR2L,CHMP6,FURIN,TCEB3,VPS4B,RANGAP1,TCEB1,VPS37C,NELFA,CHMP3,NUP214,UBC,TPR,VPS28,VPS37D,XPO1,CHMP4A,SUPT4H1,GTF2A1,POLR2J,CCNT1,RCC1,CDK9,TAF4,POLR2E,NUP93,TSG101,NCBP2,POLR2H,CHMP4B,VPS4A,CHMP7,AAAS
REACT_938	Ubiquitin-dependent degradation of Cyclin D	0.610145699192253	-0.49405749920033	51	22	0.00695542206765729	3163	7167	5689,7311,5684,5692,5721,1019,5710,9491,5685,7316,5704,595,5699,5687,122706,5696,5709,5714,5701,10213,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDK4,PSMD4,PSMF1,PSMA4,UBC,PSMC4,CCND1,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,PSME3,PSMA5
REACT_4	Ubiquitin-dependent degradation of Cyclin D1	0.610145699192253	-0.49405749920033	51	22	0.00695542206765729	3163	7167	5689,7311,5684,5692,5721,1019,5710,9491,5685,7316,5704,595,5699,5687,122706,5696,5709,5714,5701,10213,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDK4,PSMD4,PSMF1,PSMA4,UBC,PSMC4,CCND1,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,PSME3,PSMA5
REACT_111178	ER-Phagosome pathway	0.615205375603672	-0.485799122851518	65	28	0.00885235535883655	3163	7167	5689,7311,5684,5692,23480,5721,6890,567,5710,5685,9491,3105,7316,5704,811,5699,5687,122706,5696,29927,5714,5709,5701,10213,3107,10197,5686,55176	PSMB1,UBA52,PSMA3,PSMB4,SEC61G,PSME2,TAP1,B2M,PSMD4,PSMA4,PSMF1,HLA-A,UBC,PSMC4,CALR,PSMB10,PSMA6,PSMB11,PSMB8,SEC61A1,PSMD8,PSMD3,PSMC2,PSMD14,HLA-C,PSME3,PSMA5,SEC61A2
REACT_11167	Metabolism of folate and pterines	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	81034,6573,6470,2356	SLC25A32,SLC19A1,SHMT1,FPGS
REACT_121092	Regulation of Gene Expression by Hypoxia-inducible Factor	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	7422,2034,3091,405	VEGFA,EPAS1,HIF1A,ARNT
REACT_12477	eNOS activation	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	857,3320,207,340481	CAV1,HSP90AA1,AKT1,ZDHHC21
REACT_150206	Crosslinking of collagen fibrils	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	84695,4016,4015,649	LOXL3,LOXL1,LOX,BMP1
REACT_1064	Displacement of DNA glycosylase by  APE1	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	4350,4913,4595,8930	MPG,NTHL1,MUTYH,MBD4
REACT_11049	Formation of annular gap junctions	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	1211,1601,1212,1785	CLTA,DAB2,CLTB,DNM2
REACT_18425	Prostanoid ligand receptors	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	11251,5732,5739,5731	PTGDR2,PTGER2,PTGIR,PTGER1
REACT_163875	Sperm Motility And Taxes	0.618454540264554	-0.480531589827318	9	4	0.00126462219411951	3163	7167	347732,84329,157855,378807	CATSPER3,HVCN1,KCNU1,CATSPER4
REACT_24970	Factors involved in megakaryocyte development and platelet production	0.623657936686594	-0.472153239304281	139	60	0.0189693329117926	3163	7167	126961,3797,1793,11311,9493,2625,285643,8358,3661,11004,161882,25942,5566,26153,1794,10019,1020,25,7465,30846,147700,653604,3717,22920,3835,50808,81928,55604,5567,81704,10112,2626,221037,5575,23186,5868,5577,3021,830,23414,9927,8165,3796,64145,2627,10603,7975,11127,3665,3020,140628,23468,91768,23764,57572,3066,333932,3659,23348,10938	HIST2H3C,KIF3C,DOCK1,VPS45,KIF23,GATA3,KIF4B,HIST1H3B,IRF3,KIF2C,ZFPM1,SIN3A,PRKACA,KIF26A,DOCK2,SH2B3,CDK5,ABL1,WEE1,EHD2,KLC3,HIST2H3D,JAK2,KIFAP3,KIF22,AK3,CABLES2,LRRC16A,PRKACB,DOCK8,KIF20A,GATA4,JMJD1C,PRKAR1B,RCOR1,RAB5A,PRKAR2B,H3F3B,CAPZA2,ZFPM2,MFN2,AKAP1,KIF2A,ZFYVE20,GATA6,SH2B2,MAFK,KIF3A,IRF7,H3F3A,GATA5,CBX5,CABLES1,MAFF,DOCK6,HDAC2,HIST2H3A,IRF1,DOCK9,EHD1
REACT_953	RNA Polymerase I Transcription Initiation	0.624286692359005	-0.471145573241254	42	18	0.00569079987353778	3163	7167	57459,2967,902,2648,8850,6908,79101,5440,9219,53615,54815,9015,10919,9014,2968,9112,5437,3066	GATAD2B,GTF2H3,CCNH,KAT2A,KAT2B,TBP,TAF1D,POLR2K,MTA2,MBD3,GATAD2A,TAF1A,EHMT2,TAF1B,GTF2H4,MTA1,POLR2H,HDAC2
REACT_111184	Negative regulation of FGFR signaling	0.624286692359005	-0.471145573241254	42	18	0.00569079987353778	3163	7167	2264,2254,7311,2249,27006,867,6714,7316,2260,2248,5515,2246,2261,5518,26281,8817,5781,10253	FGFR4,FGF9,UBA52,FGF4,FGF22,CBL,SRC,UBC,FGFR1,FGF3,PPP2CA,FGF1,FGFR3,PPP2R1A,FGF20,FGF18,PTPN11,SPRY2
REACT_697	Activation of BH3-only proteins	0.625219752739663	-0.46965208666061	28	12	0.00379386658235852	3163	7167	90427,207,5366,10000,7027,10971,27113,5533,7534,7531,637,2810	BMF,AKT1,PMAIP1,AKT3,TFDP1,YWHAQ,BBC3,PPP3CC,YWHAZ,YWHAE,BID,SFN
REACT_111056	Cross-presentation of soluble exogenous antigens (endosomes)	0.625233124804992	-0.469630699104839	49	21	0.00663926651912741	3163	7167	5689,9902,5684,5692,5721,5710,5685,9491,5704,5699,5687,122706,5696,2209,5709,5714,5701,10213,2210,10197,5686	PSMB1,MRC2,PSMA3,PSMB4,PSME2,PSMD4,PSMA4,PSMF1,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,FCGR1A,PSMD3,PSMD8,PSMC2,PSMD14,FCGR1B,PSME3,PSMA5
REACT_23946	Prostacyclin signalling through prostacyclin receptor	0.628882729466103	-0.463810479304262	21	9	0.00284539993676889	3163	7167	2793,59345,5739,2788,2782,2786,51764,548645,2783	GNGT2,GNB4,PTGIR,GNG7,GNB1,GNG4,GNG13,DNAJC25,GNB2
REACT_734	DNA Replication Pre-Initiation	0.634325173205789	-0.455193564537016	84	36	0.0113815997470756	3163	7167	5689,55388,5684,5721,81620,10926,9491,4173,6118,5687,5696,4174,5701,10213,5686,7311,4999,5692,5558,1871,990,4171,5710,5685,7316,5704,5699,122706,5426,5714,5709,84515,29935,10197,1870,4172	PSMB1,MCM10,PSMA3,PSME2,CDT1,DBF4,PSMF1,MCM4,RPA2,PSMA6,PSMB8,MCM5,PSMC2,PSMD14,PSMA5,UBA52,ORC2,PSMB4,PRIM2,E2F3,CDC6,MCM2,PSMD4,PSMA4,UBC,PSMC4,PSMB10,PSMB11,POLE,PSMD8,PSMD3,MCM8,RPA4,PSME3,E2F2,MCM3
REACT_1725	M/G1 Transition	0.634325173205789	-0.455193564537016	84	36	0.0113815997470756	3163	7167	5689,55388,5684,5721,81620,10926,9491,4173,6118,5687,5696,4174,5701,10213,5686,7311,4999,5692,5558,1871,990,4171,5710,5685,7316,5704,5699,122706,5426,5714,5709,84515,29935,10197,1870,4172	PSMB1,MCM10,PSMA3,PSME2,CDT1,DBF4,PSMF1,MCM4,RPA2,PSMA6,PSMB8,MCM5,PSMC2,PSMD14,PSMA5,UBA52,ORC2,PSMB4,PRIM2,E2F3,CDC6,MCM2,PSMD4,PSMA4,UBC,PSMC4,PSMB10,PSMB11,POLE,PSMD8,PSMD3,MCM8,RPA4,PSME3,E2F2,MCM3
REACT_19226	Activation of Rac	0.638338080684279	-0.448887228959846	14	6	0.00189693329117926	3163	7167	5058,56924,4690,10298,2817,6091	PAK1,PAK6,NCK1,PAK4,GPC1,ROBO1
REACT_12606	GRB2 events in EGFR signaling	0.638338080684279	-0.448887228959846	14	6	0.00189693329117926	3163	7167	3845,983,3265,5894,5605,1956	KRAS,CDK1,HRAS,RAF1,MAP2K2,EGFR
REACT_25120	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.638338080684279	-0.448887228959846	14	6	0.00189693329117926	3163	7167	7189,3665,54106,3654,11344,387522	TRAF6,IRF7,TLR9,IRAK1,TWF2,TMEM189-UBE2V1
REACT_6354	Viral Messenger RNA Synthesis	0.638338080684279	-0.448887228959846	14	6	0.00189693329117926	3163	7167	5437,5438,5439,5441,5440,5434	POLR2H,POLR2I,POLR2J,POLR2L,POLR2K,POLR2E
REACT_70	Removal of the Flap Intermediate	0.638338080684279	-0.448887228959846	14	6	0.00189693329117926	3163	7167	6118,5111,5558,5424,57804,5425	RPA2,PCNA,PRIM2,POLD1,POLD4,POLD2
REACT_212	Glucose transport	0.641365567196287	-0.44415567698655	40	17	0.0053746443250079	3163	7167	6513,92579,8021,129401,11097,7175,23225,2542,2645,55746,9688,3099,3098,3101,79902,8086,81929	SLC2A1,G6PC3,NUP214,NUP35,NUPL2,TPR,NUP210,SLC37A4,GCK,NUP133,NUP93,HK2,HK1,HK3,NUP85,AAAS,SEH1L
REACT_6319	Formation of the HIV-1 Early Elongation Complex	0.643190953642434	-0.441313625826932	33	14	0.00442617767941827	3163	7167	9150,2967,6827,5438,902,5439,5441,2968,5440,5434,22916,5437,7469,25920	CTDP1,GTF2H3,SUPT4H1,POLR2I,CCNH,POLR2J,POLR2L,GTF2H4,POLR2K,POLR2E,NCBP2,POLR2H,NELFA,NELFB
REACT_163931	Nuclear Pore Complex (NPC) Disassembly	0.643190953642434	-0.441313625826932	33	14	0.00442617767941827	3163	7167	11097,7175,23225,10783,55746,140609,9688,891,8021,79902,983,81929,129401,8086	NUPL2,TPR,NUP210,NEK6,NUP133,NEK7,NUP93,CCNB1,NUP214,NUP85,CDK1,SEH1L,NUP35,AAAS
REACT_846	Formation of the Early Elongation Complex	0.643190953642434	-0.441313625826932	33	14	0.00442617767941827	3163	7167	9150,2967,6827,5438,902,5439,5441,2968,5440,5434,22916,5437,7469,25920	CTDP1,GTF2H3,SUPT4H1,POLR2I,CCNH,POLR2J,POLR2L,GTF2H4,POLR2K,POLR2E,NCBP2,POLR2H,NELFA,NELFB
REACT_25201	Kinesins	0.647206680840779	-0.435089590607606	26	11	0.00347771103382864	3163	7167	3796,3797,10112,147700,11127,9493,22920,3835,285643,11004,26153	KIF2A,KIF3C,KIF20A,KLC3,KIF3A,KIF23,KIFAP3,KIF22,KIF4B,KIF2C,KIF26A
REACT_18372	Class B/2 (Secretin family receptors)	0.647341776217059	-0.434880876324206	89	38	0.0120139108441353	3163	7167	5745,8325,7472,11211,6344,2782,10267,2783,8323,9340,1395,10268,2793,80326,2642,51764,89780,7484,8321,7483,1604,2740,7476,2788,2786,5727,7477,7481,548645,7478,2015,54361,7475,59345,6469,976,7855,117	PTH1R,FZD8,WNT2,FZD10,SCTR,GNB1,RAMP1,GNB2,FZD6,GLP2R,CRHR2,RAMP3,GNGT2,WNT10A,GCGR,GNG13,WNT3A,WNT9B,FZD1,WNT9A,CD55,GLP1R,WNT7A,GNG7,GNG4,PTCH1,WNT7B,WNT11,DNAJC25,WNT8A,EMR1,WNT4,WNT6,GNB4,SHH,CD97,FZD5,ADCYAP1R1
REACT_6256	HIV Life Cycle	0.65173350030109	-0.428119542482705	140	60	0.0189693329117926	3163	7167	4836,9150,920,10015,6908,5440,3978,129401,11097,8178,2961,23225,2968,55746,5902,79902,81929,25920,2967,6881,5438,7311,902,6923,5441,79643,5045,6924,9525,5905,6921,55048,7469,51652,8021,7316,7520,7175,51160,155382,6827,7514,29082,2957,5439,904,1104,1025,6874,5434,9688,7251,22916,5437,128866,3159,27183,91782,8086,1234	NMT1,CTDP1,CD4,PDCD6IP,TBP,POLR2K,LIG1,NUP35,NUPL2,ELL,GTF2E2,NUP210,GTF2H4,NUP133,RANBP1,NUP85,SEH1L,NELFB,GTF2H3,TAF10,POLR2I,UBA52,CCNH,TCEB2,POLR2L,CHMP6,FURIN,TCEB3,VPS4B,RANGAP1,TCEB1,VPS37C,NELFA,CHMP3,NUP214,UBC,XRCC5,TPR,VPS28,VPS37D,SUPT4H1,XPO1,CHMP4A,GTF2A1,POLR2J,CCNT1,RCC1,CDK9,TAF4,POLR2E,NUP93,TSG101,NCBP2,POLR2H,CHMP4B,HMGA1,VPS4A,CHMP7,AAAS,CCR5
REACT_12389	eNOS activation and regulation	0.655485987328822	-0.42237835307961	19	8	0.00252924438823901	3163	7167	207,1785,5805,5593,3320,857,51070,340481	AKT1,DNM2,PTS,PRKG2,HSP90AA1,CAV1,NOSIP,ZDHHC21
REACT_12508	Metabolism of nitric oxide	0.655485987328822	-0.42237835307961	19	8	0.00252924438823901	3163	7167	207,1785,5805,5593,3320,857,51070,340481	AKT1,DNM2,PTS,PRKG2,HSP90AA1,CAV1,NOSIP,ZDHHC21
REACT_20546	Ras activation uopn Ca2+ infux through NMDA receptor	0.655485987328822	-0.42237835307961	19	8	0.00252924438823901	3163	7167	5923,817,88,816,3265,818,815,2902	RASGRF1,CAMK2D,ACTN2,CAMK2B,HRAS,CAMK2G,CAMK2A,GRIN1
REACT_163862	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.655485987328822	-0.42237835307961	19	8	0.00252924438823901	3163	7167	1504,4594,81693,440387,326625,4548,166785,51293	CTRB1,MUT,AMN,CTRB2,MMAB,MTR,MMAA,CD320
REACT_85	p53-Dependent G1/S DNA damage checkpoint	0.655512945272416	-0.422337227274048	59	25	0.00790388871324692	3163	7167	9134,5689,7311,5684,5692,5721,1026,5710,9491,898,5685,7316,5704,64326,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CCNE2,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDKN1A,PSMD4,PSMF1,CCNE1,PSMA4,UBC,PSMC4,RFWD2,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_1625	p53-Dependent G1 DNA Damage Response	0.655512945272416	-0.422337227274048	59	25	0.00790388871324692	3163	7167	9134,5689,7311,5684,5692,5721,1026,5710,9491,898,5685,7316,5704,64326,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	CCNE2,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDKN1A,PSMD4,PSMF1,CCNE1,PSMA4,UBC,PSMC4,RFWD2,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_207	Removal of licensing factors from origins	0.656368242922018	-0.42103330161602	73	31	0.00980082200442618	3163	7167	5689,55388,4999,7311,5684,5692,5721,81620,990,1026,5710,4171,9491,5685,7316,5704,4173,5699,5687,122706,5696,5709,5714,4174,5701,51343,84515,10213,10197,5686,4172	PSMB1,MCM10,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,CDC6,CDKN1A,PSMD4,MCM2,PSMF1,PSMA4,UBC,PSMC4,MCM4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,MCM5,PSMC2,FZR1,MCM8,PSMD14,PSME3,PSMA5,MCM3
REACT_163769	Role of LAT2/NTAL/LAB on calcium mobilization	0.656437133147766	-0.420928350452555	124	53	0.0167562440720835	3163	7167	685,1839,57690,7249,942,2475,27161,79109,2064,9542,1026,23239,4067,7409,5154,2261,6464,5296,117145,5781,5290,8503,2065,1385,3815,6850,5159,64223,6199,2264,5170,2254,207,2931,2249,3164,27006,5295,1956,2260,2248,2246,57761,2534,10718,10000,26281,8817,4254,2932,3084,940,27327	BTC,HBEGF,TNRC6C,TSC2,CD86,MTOR,AGO2,MAPKAP1,ERBB2,NRG2,CDKN1A,PHLPP1,LYN,VAV1,PDGFA,FGFR3,SHC1,PIK3R2,THEM4,PTPN11,PIK3CA,PIK3R3,ERBB3,CREB1,KIT,SYK,PDGFRB,MLST8,RPS6KB2,FGFR4,PDPK1,FGF9,AKT1,GSK3A,FGF4,NR4A1,FGF22,PIK3R1,EGFR,FGFR1,FGF3,FGF1,TRIB3,FYN,NRG3,AKT3,FGF20,FGF18,KITLG,GSK3B,NRG1,CD28,TNRC6A
REACT_13523	Vitamin D (calciferol) metabolism	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	1591,5641,120227	CYP24A1,LGMN,CYP2R1
5416962	NCAM signaling for neurite out-growth	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	51332,57731,6710	SPTBN5,SPTBN4,SPTB
REACT_118699	Post-transcriptional Silencing By Small RNAs	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	57690,27161,27327	TNRC6C,AGO2,TNRC6A
REACT_705	PP2A-mediated dephosphorylation of key metabolic factors	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	5515,5518,5528	PPP2CA,PPP2R1A,PPP2R5D
REACT_163725	Proteolytic Processing of SUMO	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	6612,205564,59343	SUMO3,SENP5,SENP2
REACT_11200	Nef Mediated CD8 Down-regulation	0.666574344276979	-0.405603601282434	7	3	0.00094846664558963	3163	7167	161,51606,160	AP2A2,ATP6V1H,AP2A1
REACT_2148	Switching of origins to a post-replicative state	0.66873921821901	-0.402361103191217	71	30	0.0094846664558963	3163	7167	5689,4999,7311,5684,5692,5721,81620,990,1026,5710,4171,9491,5685,7316,5704,4173,5699,5687,122706,5696,5709,5714,4174,5701,51343,84515,10213,10197,5686,4172	PSMB1,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,CDC6,CDKN1A,PSMD4,MCM2,PSMF1,PSMA4,UBC,PSMC4,MCM4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,MCM5,PSMC2,FZR1,MCM8,PSMD14,PSME3,PSMA5,MCM3
REACT_1156	Orc1 removal from chromatin	0.66873921821901	-0.402361103191217	71	30	0.0094846664558963	3163	7167	5689,4999,7311,5684,5692,5721,81620,990,1026,5710,4171,9491,5685,7316,5704,4173,5699,5687,122706,5696,5709,5714,4174,5701,51343,84515,10213,10197,5686,4172	PSMB1,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,CDC6,CDKN1A,PSMD4,MCM2,PSMF1,PSMA4,UBC,PSMC4,MCM4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,MCM5,PSMC2,FZR1,MCM8,PSMD14,PSME3,PSMA5,MCM3
REACT_12526	TCR signaling	0.668886282262179	-0.402141214973314	64	27	0.00853619981030667	3163	7167	5058,5170,7189,27040,920,4690,3635,387522,5295,10892,55740,3937,5788,3113,3123,5335,8517,7454,23118,919,4792,4790,3551,5296,5290,6885,646626	PAK1,PDPK1,TRAF6,LAT,CD4,NCK1,INPP5D,TMEM189-UBE2V1,PIK3R1,MALT1,ENAH,LCP2,PTPRC,HLA-DPA1,HLA-DRB1,PLCG1,IKBKG,WAS,TAB2,CD247,NFKBIA,NFKB1,IKBKB,PIK3R2,PIK3CA,MAP3K7,LOC646626
REACT_172638	Asymmetric localization of PCP proteins	0.668886282262179	-0.402141214973314	64	27	0.00853619981030667	3163	7167	5689,7311,5684,5692,5721,8325,144165,23513,5710,57216,5685,9491,7316,5704,5699,5687,122706,5696,5714,5709,5701,10213,10197,7855,1856,5686,8321	PSMB1,UBA52,PSMA3,PSMB4,PSME2,FZD8,PRICKLE1,SCRIB,PSMD4,VANGL2,PSMA4,PSMF1,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,PSME3,FZD5,DVL2,PSMA5,FZD1
REACT_9003	SCF(Skp2)-mediated degradation of p27/p21	0.669562618855971	-0.401130587446491	57	24	0.00758773316471704	3163	7167	9134,5689,7311,5684,5692,5721,1026,5710,898,5685,9491,7316,5704,5699,5687,5696,5709,5714,5701,10213,1163,6500,10197,5686	CCNE2,PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDKN1A,PSMD4,CCNE1,PSMA4,PSMF1,UBC,PSMC4,PSMB10,PSMA6,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,CKS1B,SKP1,PSME3,PSMA5
REACT_121111	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.670652549942779	-0.399504085445219	24	10	0.00316155548529877	3163	7167	4088,7323,9612,7050,7311,4087,142,4089,7316,6497	SMAD3,UBE2D3,NCOR2,TGIF1,UBA52,SMAD2,PARP1,SMAD4,UBC,SKI
REACT_20653	ADP signalling through P2Y purinoceptor 12	0.670652549942779	-0.399504085445219	24	10	0.00316155548529877	3163	7167	2793,59345,2788,346562,2786,2782,51764,2771,548645,2783	GNGT2,GNB4,GNG7,GNAT3,GNG4,GNB1,GNG13,GNAI2,DNAJC25,GNB2
REACT_1074	RNA Polymerase I Transcription Termination	0.670652549942779	-0.399504085445219	24	10	0.00316155548529877	3163	7167	9015,2967,284119,902,9014,2968,6908,79101,5440,5437	TAF1A,GTF2H3,PTRF,CCNH,TAF1B,GTF2H4,TBP,TAF1D,POLR2K,POLR2H
REACT_20639	Deadenylation-dependent mRNA decay	0.67097839026696	-0.399018347794391	50	21	0.00663926651912741	3163	7167	1975,23019,9337,25804,1973,85456,5073,219988,167227,9924,4849,1981,25904,11157,56915,55802,57472,54512,27257,1977,26986	EIF4B,CNOT1,CNOT8,LSM4,EIF4A1,TNKS1BP1,PARN,PATL1,DCP2,PAN2,CNOT3,EIF4G1,CNOT10,LSM6,EXOSC5,DCP1A,CNOT6,EXOSC4,LSM1,EIF4E,PABPC1
REACT_1046	Pyruvate metabolism and Citric Acid (TCA) cycle	0.673464285554702	-0.395320312667378	43	18	0.00569079987353778	3163	7167	79944,5160,6391,2271,9123,3939,682,3418,4967,1743,51660,23539,6390,5164,25874,728294,55066,3945	L2HGDH,PDHA1,SDHC,FH,SLC16A3,LDHA,BSG,IDH2,OGDH,DLST,MPC1,SLC16A8,SDHB,PDK2,MPC2,D2HGDH,PDPR,LDHB
REACT_1753	mRNA Splicing - Minor Pathway	0.673464285554702	-0.395320312667378	43	18	0.00569079987353778	3163	7167	5438,5441,5440,6628,6431,51639,6635,10907,83443,6426,10992,6427,6632,10262,5439,5434,5437,22916	POLR2I,POLR2L,POLR2K,SNRPB,SRSF6,SF3B14,SNRPE,TXNL4A,SF3B5,SRSF1,SF3B2,SRSF2,SNRPD1,SF3B4,POLR2J,POLR2E,POLR2H,NCBP2
REACT_12436	ERKs are inactivated	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	5515,1846,5518,5528,1849	PPP2CA,DUSP4,PPP2R1A,PPP2R5D,DUSP7
REACT_933	Resolution of AP sites via the single-nucleotide replacement pathway	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	3980,4350,4913,4595,8930	LIG3,MPG,NTHL1,MUTYH,MBD4
REACT_494	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	857,5499,5566,5567,51099	CAV1,PPP1CA,PRKACA,PRKACB,ABHD5
REACT_13541	Caspase-mediated cleavage of cytoskeletal proteins	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	7431,2934,5339,118,839	VIM,GSN,PLEC,ADD1,CASP6
REACT_115529	Interleukin-7 signaling	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	8503,3082,6776,5296,5295	PIK3R3,HGF,STAT5A,PIK3R2,PIK3R1
REACT_15425	Serotonin Neurotransmitter Release Cycle	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	10815,6804,6571,8224,5864	CPLX1,STX1A,SLC18A2,SYN3,RAB3A
REACT_19238	CD28 dependent Vav1 pathway	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	5058,7409,2534,942,940	PAK1,VAV1,FYN,CD86,CD28
REACT_15293	Dopamine Neurotransmitter Release Cycle	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	10815,6804,6571,8224,5864	CPLX1,STX1A,SLC18A2,SYN3,RAB3A
REACT_121123	Reversible Hydration of Carbon Dioxide	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	763,766,23632,762,771	CA5A,CA7,CA14,CA4,CA12
REACT_19343	Facilitative Na+-independent glucose transporters	0.673933162224855	-0.39462433882558	12	5	0.00158077774264938	3163	7167	56606,29988,155184,6513,81031	SLC2A9,SLC2A8,SLC2A7,SLC2A1,SLC2A10
REACT_25046	Transport to the Golgi and subsequent modification	0.677573311270888	-0.389237523564485	36	15	0.00474233322794815	3163	7167	51128,10802,4248,4122,22872,6484,6396,79694,4245,11282,2683,8703,90411,8702,10113	SAR1B,SEC24A,MGAT3,MAN2A2,SEC31A,ST3GAL4,SEC13,MANEA,MGAT1,MGAT4B,B4GALT1,B4GALT3,MCFD2,B4GALT4,PREB
REACT_24915	Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	9261,55802,677,54512,207,167227,56915	MAPKAPK2,DCP1A,ZFP36L1,EXOSC4,AKT1,DCP2,EXOSC5
REACT_121155	Signaling by FGFR2 mutants	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	2246,2254,2249,27006,26281,8817,2248	FGF1,FGF9,FGF4,FGF22,FGF20,FGF18,FGF3
REACT_9390	FGFR2 ligand binding and activation	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	2246,2254,2249,27006,26281,8817,2248	FGF1,FGF9,FGF4,FGF22,FGF20,FGF18,FGF3
REACT_20594	Unblocking of NMDA receptor, glutamate binding and activation	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	2890,817,88,816,818,815,2902	GRIA1,CAMK2D,ACTN2,CAMK2B,CAMK2G,CAMK2A,GRIN1
REACT_20642	CREB phosphorylation through the activation of CaMKII	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	817,88,1385,816,818,815,2902	CAMK2D,ACTN2,CREB1,CAMK2B,CAMK2G,CAMK2A,GRIN1
REACT_120863	Activated point mutants of FGFR2	0.684646089428485	-0.378853232002161	17	7	0.00221308883970914	3163	7167	2246,2254,2249,27006,26281,8817,2248	FGF1,FGF9,FGF4,FGF22,FGF20,FGF18,FGF3
REACT_15391	Serotonin clearance from the synaptic cleft	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	4128	MAOA
REACT_14800	Agmatine biosynthesis	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	113451	ADC
REACT_11076	BoNT Light Chain Types B, D, and F cleave VAMP/Synaptobrevin	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	6843	VAMP1
5417894	Synthesis of PIPs at the late endosome membrane	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_1183	ERK2 activation	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	5605	MAP2K2
5417874	PI Metabolism	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_19348	Proton-coupled neutral amino acid transporters	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	206358	SLC36A1
REACT_11060	TRKA activation by NGF	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	4914	NTRK1
REACT_476	DNA Damage Recognition in GG-NER	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	5887	RAD23B
REACT_346	Transcriptional  activation of  cell cycle inhibitor p21	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	1026	CDKN1A
5417896	Synthesis of PIPs at the Golgi membrane	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_12020	Signalling to ERK5	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	5607	MAP2K5
REACT_1571	Fructose catabolism	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	3795	KHK
5417898	Synthesis of PIPs at the early endosome membrane	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_1322	Release of apoptotic factors from the mitochondria	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	54205	CYCS
REACT_15532	Metabolism of serotonin	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	4128	MAOA
REACT_416	Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	4128	MAOA
REACT_2020	Reversal of Alkylation Damage By DNA Dioxygenases	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	221120	ALKBH3
REACT_202	Transcriptional activation of p53 responsive genes	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	1026	CDKN1A
5416908	Phospholipid metabolism	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_13438	Sterols are 12-hydroxylated by CYP8B1	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	5740	PTGIS
REACT_795	Amplification of signal from the kinetochores	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	8379	MAD1L1
REACT_505	Polyamines are oxidized to amines, aldehydes and H2O2 by PAOs	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	54498	SMOX
REACT_11085	Translocation of BoNT Light chain	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	127833	SYT2
REACT_584	Activation, translocation and oligomerization of BAX	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	637	BID
REACT_15466	phospho-PLA2 pathway	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	5321	PLA2G4A
REACT_12510	NOSIP mediated eNOS trafficking	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	51070	NOSIP
REACT_491	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	8379	MAD1L1
5416688	Metabolism	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_11139	Nef mediated downregulation of CD28 cell surface expression	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	940	CD28
REACT_1016	Mitotic Metaphase/Anaphase Transition	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	26271	FBXO5
REACT_6822	Transfer of LPS from LBP carrier to CD14	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	929	CD14
5416724	Metabolism of lipids and lipoproteins	0.687920349730306	-0.374082218491577	2	1	0.000316155548529877	3163	7167	55697	VAC14
REACT_17015	Metabolism of proteins	0.694759774934868	-0.364189140742966	693	300	0.094846664558963	3163	7167	118,5589,5611,9091,10165,1964,7329,3483,6484,4585,9695,29928,55770,10574,1363,7277,7311,3484,63971,51809,90411,10376,5372,291,79694,3703,6208,3972,6483,6188,3487,140453,64061,1725,23480,79087,4588,2683,54344,80031,6748,5073,100137049,23521,4000,134266,200958,6137,811,6184,6170,4313,54872,3952,1537,56005,1509,26986,1936,2999,1984,5279,93010,6154,51604,29929,8858,11253,6229,6746,4580,10452,7458,59343,167227,6818,22872,6726,5204,340075,3488,6223,8892,85365,723961,37,43,10331,4248,64924,10383,79695,8664,9451,84617,410,440,6464,50614,56915,55650,10576,2931,6169,6232,467,26985,27230,3630,6191,26234,27335,7278,29927,1650,7466,5624,6176,727897,22926,8703,6396,3489,1636,3800,2621,26270,1915,5281,4245,3485,54512,10651,51360,1975,374907,5045,6132,9245,1973,153642,10897,51128,2159,6161,183,1968,6804,79644,8570,411,2155,116138,1649,6905,93183,3068,8663,55757,3646,84920,6745,58477,11328,6141,1499,8733,146712,1983,374378,1977,10159,55176,7709,83475,2147,468,80273,6160,3309,6612,4583,4736,10610,29926,10469,4122,4582,1981,26517,4800,57171,3576,442117,60,55568,8720,7094,26272,114805,8702,26519,2688,56913,6205,5972,149371,56993,5277,94005,440081,9114,10113,516,11282,80267,64409,84447,197257,6934,9709,25873,2590,6675,498,445329,4311,54461,9945,9804,6181,6235,285596,79642,821,3817,6135,22948,23478,56605,4157,55294,2107,5627,10130,205564,3486,144245,10802,6159,6142,7416,2671,8666,91869,6487,6203,8667,3921,290,79947,9314,1978,10440,346562,29925,10071,117248,8891,8662,6146,6482,394263,6202,7280,1663,8877,285362,23265,5373,27090,4189,60676,6234,3625,51764,55033,2650,10381,9761,2626,5329,7203,8890,79623,5201,6189,55738,3313,6206	ADD1,PRKCSH,DNAJC3,PIGQ,SLC25A13,EIF1AX,UBE2I,IGFALS,ST3GAL4,MUC4,EDEM1,TIMM22,EXOC2,CCT7,CPE,TUBA4A,UBA52,IGFBP1,KIF13A,GALNT7,MCFD2,TUBA1B,PMM1,SLC25A4,MANEA,STT3A,RPS14,LHB,ST3GAL2,RPS3,IGFBP4,MUC17,TSPYL2,DHPS,SEC61G,ALG12,MUC6,B4GALT1,DPM3,SEMA6D,SSR4,PARN,PLA2G4B,RPL13A,LMNA,GRPEL2,MUC20,RPL13,CALR,RPN1,RPL39,MMP2,PIGG,LEP,CYC1,C19orf10,CTSD,PABPC1,EEF1D,GZMH,EIF5A,PIGC,B3GNT7,RPL26,PIGT,ALG6,PROZ,MAN1B1,RPS24,SSR2,MTX1,TOMM40,EIF4H,SENP2,DCP2,SULT1A3,SEC31A,SRP9,PFDN5,ARSI,IGFBP5,RPS19,EIF2B2,ALG2,INS-IGF2,ACADVL,ACHE,B3GNT3,MGAT3,SLC30A5,TUBB4B,GALNT12,EIF3D,EIF2AK3,TUBB6,ARSA,ASNS,SHC1,GALNT9,EXOSC5,PIGV,CCT2,GSK3A,RPL38,RPS27,ATF3,AP3M1,SERP1,INS,RPS4X,FBXL5,EIF3K,TUBA3C,SEC61A1,DDOST,WFS1,PROC,RPLP1,MUC5B,ATF6,B4GALT3,SEC13,IGFBP6,ACE,KIF5C,GAS6,FBXO6,EEF1A1,PIGF,MGAT1,IGFBP2,EXOSC4,MTX2,MBTPS2,EIF4B,B3GNT8,FURIN,RPL8,GCNT3,EIF4A1,ARSK,YIF1A,SAR1B,F10,RPL32,AGT,EIF2S3,STX1A,SRD5A3,KHSRP,ARSB,F7,KLHDC3,DDIT3,TBCE,PIGM,HDGF,EIF3C,UGGT2,EIF3E,ALG10,SSR1,SRPRB,FKBP9,RPL18,CTNNB1,GPAA1,B3GNTL1,EIF5,GALNT18,EIF4E,ATP6AP2,SEC61A2,ZBTB17,DOHH,F2,ATF4,GRPEL1,RPL31,HSPA5,SUMO3,MUC2,RPL10A,ST6GALNAC2,GMPPA,TIMM44,MAN2A2,MUC1,EIF4G1,TIMM13,NFYA,DOLPP1,IL8,GALNTL6,ACTB,GALNT10,MBTPS1,TLN1,FBXO4,GALNT13,B4GALT4,TIMM10,GH1,C1GALT1,RPS11,REN,EXOC8,TOMM22,PIGA,PIGS,DDX12P,ATP6V0D1,PREB,ATP5G1,MGAT4B,EDEM3,WBSCR17,SYVN1,LDHD,TCF7L2,HERPUD1,RPL36,GALNT2,UAP1,ATP5A1,SULT1A4,MME,FBXW5,GFPT2,TOMM20,RPLP2,RPS29,FAM153A,ARSJ,CANX,KLK2,RPL11,CCT5,SEC11A,ERO1LB,MC1R,FBXW7,ETF1,PROS1,PDIA6,SENP5,IGFBP3,ALG10B,SEC24A,RPL29,RPL18A,VDAC1,GFER,EIF3G,RFT1,ST3GAL3,RPS9,EIF3H,RPSA,ANPEP,DHDDS,KLF4,EIF4EBP1,TIMM17A,GNAT3,GMPPB,MUC12,GALNT15,EIF2B3,EIF3B,RPL22,ST3GAL1,MUC21,RPS8,TUBB2A,DDX11,SPHK1,SUMF1,EXOC7,PMM2,ST6GALNAC4,DNAJB9,PAPPA2,RPS28,INHBB,GNG13,FKBP14,GCNT1,TUBB3,MLEC,GATA4,PLAUR,CCT3,EIF2B4,GALNT14,PFDN1,RPS3A,ARFGAP1,HSPA9,RPS12
REACT_22272	Signal transduction by L1	0.695721905106941	-0.362805260121693	22	9	0.00284539993676889	3163	7167	5058,7410,3688,3685,8829,3897,5605,2260,1956	PAK1,VAV2,ITGB1,ITGAV,NRP1,L1CAM,MAP2K2,FGFR1,EGFR
REACT_22107	RNA Polymerase II Pre-transcription Events	0.695891041343694	-0.362562180696459	60	25	0.00790388871324692	3163	7167	9150,2967,6881,5438,902,6923,5441,6908,5440,6924,6921,7469,8178,2961,6827,5439,2957,2968,904,1025,6874,5434,22916,5437,25920	CTDP1,GTF2H3,TAF10,POLR2I,CCNH,TCEB2,POLR2L,TBP,POLR2K,TCEB3,TCEB1,NELFA,ELL,GTF2E2,SUPT4H1,POLR2J,GTF2A1,GTF2H4,CCNT1,CDK9,TAF4,POLR2E,NCBP2,POLR2H,NELFB
REACT_910	M Phase	0.696033883614993	-0.362356936477838	301	129	0.0407840657603541	3163	7167	126961,5684,2029,8349,8358,11004,891,64682,5696,23225,10783,5701,10393,23047,8379,81929,7112,1058,8615,7311,23133,85236,3021,10592,983,25936,5714,8337,128312,7443,5528,8086,51433,5689,22919,1063,9493,11243,8970,129401,4000,11097,2010,81876,79648,79902,5686,9184,10112,10274,26003,5685,7324,5704,84930,5699,996,2801,113130,9688,54820,3619,333932,5885,5721,83540,8290,25909,5687,4001,55746,5518,10213,51434,3017,23141,8370,632,991,6232,701,8697,5861,8021,79682,5515,3796,5529,122706,8881,7514,79980,5525,5709,8243,7444,23383,10776,8338,3020,151648,55844,6396,54908,9491,91687,26271,55920,387893,653604,699,79019,10726,11130,5692,1060,140609,5905,5710,7316,221496,7175,6418,147841,80152,10197,54892,11065,29945	HIST2H3C,PSMA3,ENSA,HIST2H2BE,HIST1H3B,KIF2C,CCNB1,ANAPC1,PSMB8,NUP210,NEK6,PSMC2,ANAPC10,PDS5B,MAD1L1,SEH1L,TMPO,CENPA,USO1,UBA52,PHF8,HIST1H2BK,H3F3B,SMC2,CDK1,NSL1,PSMD8,HIST2H2AA3,HIST3H2BB,VRK1,PPP2R5D,AAAS,ANAPC5,PSMB1,MAPRE1,CENPF,KIF23,PMF1,HIST1H2BJ,NUP35,LMNA,NUPL2,EMD,RAB1B,MCPH1,NUP85,PSMA5,BUB3,KIF20A,STAG1,GORASP2,PSMA4,UBE2E1,PSMC4,MASTL,PSMB10,CDC27,GOLGA2,CDCA5,NUP93,NDE1,INCENP,HIST2H3A,RAD21,PSME2,NUF2,HIST3H3,AHCTF1,PSMA6,LMNB1,NUP133,PPP2R1A,PSMD14,ANAPC7,HIST1H2BD,ANKLE2,HIST2H4A,BGLAP,CDC20,RPS27,BUB1B,CDC23,RAB1A,NUP214,CENPU,PPP2CA,KIF2A,PPP2R5E,PSMB11,CDC16,XPO1,DSN1,PPP2R5A,PSMD3,SMC1A,VRK2,MAU2,ARPP19,HIST2H2AC,H3F3A,SGOL1,PPP2R2D,SEC13,SPDL1,PSMF1,CENPL,FBXO5,RCC2,SETD8,HIST2H3D,BUB1,CENPM,NUDC,ZWINT,PSMB4,CENPC,NEK7,RANGAP1,PSMD4,UBC,LEMD2,TPR,SET,SPC24,CENPT,PSME3,NCAPG2,UBE2C,ANAPC4
REACT_21312	Activation of Kainate Receptors upon glutamate binding	0.696767201055406	-0.361303925367717	34	14	0.00442617767941827	3163	7167	2900,2793,59345,83988,2788,1739,2899,2786,2782,51764,5330,2783,548645,5331	GRIK4,GNGT2,GNB4,NCALD,GNG7,DLG1,GRIK3,GNG4,GNB1,GNG13,PLCB2,GNB2,DNAJC25,PLCB3
REACT_20549	Autodegradation of the E3 ubiquitin ligase COP1	0.698588818843672	-0.358692951828139	53	22	0.00695542206765729	3163	7167	5689,7311,5684,5692,5721,5710,5685,9491,7316,5704,64326,5699,5687,122706,5696,5714,5709,5701,10213,472,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,PSMD4,PSMA4,PSMF1,UBC,PSMC4,RFWD2,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_21247	FRS2-mediated cascade	0.708242017851101	-0.344969410577025	39	16	0.00505848877647803	3163	7167	2264,2254,2249,5894,27006,3845,983,5605,2260,2248,2246,2261,8817,26281,5781,3265	FGFR4,FGF9,FGF4,RAF1,FGF22,KRAS,CDK1,MAP2K2,FGFR1,FGF3,FGF1,FGFR3,FGF18,FGF20,PTPN11,HRAS
REACT_1221	CDK-mediated phosphorylation and removal of Cdc6	0.713561274029099	-0.337486967645903	51	21	0.00663926651912741	3163	7167	5689,7311,5684,5692,5721,990,5710,9491,5685,7316,5704,5699,5687,122706,5696,5709,5714,5701,10213,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,CDC6,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,PSME3,PSMA5
REACT_147851	Arachidonic acid metabolism	0.713561274029099	-0.337486967645903	51	21	0.00663926651912741	3163	7167	5321,2678,127281,6916,22949,2687,240,9261,5743,873,4056,57834,5740,5730,3248,1800,5742,4048,2876,9536,2879	PLA2G4A,GGT1,FAM213B,TBXAS1,PTGR1,GGT5,ALOX5,MAPKAPK2,PTGS2,CBR1,LTC4S,CYP4F11,PTGIS,PTGDS,HPGD,DPEP1,PTGS1,LTA4H,GPX1,PTGES,GPX4
REACT_121189	Abacavir transport and metabolism	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	6582,6581,2987,5105	SLC22A2,SLC22A3,GUK1,PCK1
REACT_23765	Reduction of cytosolic Ca++ levels	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	492,489,493,491	ATP2B3,ATP2A3,ATP2B4,ATP2B2
REACT_18426	Opsins	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	2652,94233,728458,23596	OPN1MW,OPN4,OPN1MW2,OPN3
REACT_163793	Processing and Activation of SUMO	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	6612,7329,205564,59343	SUMO3,UBE2I,SENP5,SENP2
REACT_150188	Synthesis of pyrophosphates in the cytosol	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	64768,9807,117283,11165	IPPK,IP6K1,IP6K3,NUDT3
REACT_163932	Activation of the phototransduction cascade	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	2779,2782,5158,5145	GNAT1,GNB1,PDE6B,PDE6A
REACT_11035	Gap junction degradation	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	1211,1601,1212,1785	CLTA,DAB2,CLTB,DNM2
REACT_20603	Zinc influx into cells by the SLC39 gene family	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	55630,57181,29985,27173	SLC39A4,SLC39A10,SLC39A3,SLC39A1
REACT_120918	Synthesis of PIPs at the late endosome membrane	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	4534,9110,5286,55697	MTM1,MTMR4,PIK3C2A,VAC14
REACT_11153	Biotin transport and metabolism	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	5096,5091,64087,56922	PCCB,PC,MCCC2,MCCC1
REACT_160130	Retinoid cycle disease events	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	64220,2652,728458,6017	STRA6,OPN1MW,OPN1MW2,RLBP1
REACT_163823	SUMOylation	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	6612,7329,205564,59343	SUMO3,UBE2I,SENP5,SENP2
REACT_185	SLBP independent Processing of Histone Pre-mRNAs	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	22916,6635,134353,6628	NCBP2,SNRPE,LSM11,SNRPB
REACT_1357	Base-free sugar-phosphate removal via the single-nucleotide replacement pathway	0.715403379027385	-0.334908728898337	10	4	0.00126462219411951	3163	7167	4350,4913,4595,8930	MPG,NTHL1,MUTYH,MBD4
REACT_9395	Nuclear import of Rev protein	0.716728798579993	-0.33305775459338	32	13	0.0041100221308884	3163	7167	11097,7175,23225,1104,55746,9688,4869,8021,79902,81929,3837,129401,8086	NUPL2,TPR,NUP210,RCC1,NUP133,NUP93,NPM1,NUP214,NUP85,SEH1L,KPNB1,NUP35,AAAS
REACT_2051	Formation of Fibrin Clot (Clotting Cascade)	0.716728798579993	-0.33305775459338	32	13	0.0041100221308884	3163	7167	2165,2147,2159,5547,2162,5624,2812,2815,7450,5627,2155,462,2153	F13B,F2,F10,PRCP,F13A1,PROC,GP1BB,GP9,VWF,PROS1,F7,SERPINC1,F5
REACT_18377	Glucagon-type ligand receptors	0.716728798579993	-0.33305775459338	32	13	0.0041100221308884	3163	7167	9340,2740,2793,59345,2642,2788,6344,2786,2782,51764,2783,117,548645	GLP2R,GLP1R,GNGT2,GNB4,GCGR,GNG7,SCTR,GNG4,GNB1,GNG13,GNB2,ADCYAP1R1,DNAJC25
REACT_424	Transport of the SLBP independent Mature mRNA	0.716728798579993	-0.33305775459338	32	13	0.0041100221308884	3163	7167	11097,7175,23225,10189,55746,9688,22916,1977,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,ALYREF,NUP133,NUP93,NCBP2,EIF4E,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_20518	mRNA Decay by 5' to 3' Exoribonuclease	0.716833338416997	-0.332911908334621	15	6	0.00189693329117926	3163	7167	55802,25804,27257,11157,219988,167227	DCP1A,LSM4,LSM1,LSM6,PATL1,DCP2
REACT_172599	WNT5A-dependent internalization of FZD4	0.716833338416997	-0.332911908334621	15	6	0.00189693329117926	3163	7167	1211,161,1212,5578,160,1856	CLTA,AP2A2,CLTB,PRKCA,AP2A1,DVL2
REACT_15381	p130Cas linkage to MAPK signaling for integrins	0.716833338416997	-0.332911908334621	15	6	0.00189693329117926	3163	7167	7450,5747,2335,9564,7094,6714	VWF,PTK2,FN1,BCAR1,TLN1,SRC
REACT_9453	Vif-mediated degradation of APOBEC3G	0.723845544050596	-0.323177246302674	56	23	0.00727157761618716	3163	7167	5689,7311,5684,5692,6923,9978,5721,6921,5710,5685,9491,7316,5704,5699,5687,122706,5696,5714,5709,5701,10213,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,TCEB2,RBX1,PSME2,TCEB1,PSMD4,PSMA4,PSMF1,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD8,PSMD3,PSMC2,PSMD14,PSME3,PSMA5
REACT_25229	Interferon Signaling	0.723965252801049	-0.323011881116857	173	73	0.023079355042681	3163	7167	5724,3661,5495,2317,3113,8554,5696,23225,6672,8651,2209,7706,55746,5300,103,1977,81929,815,4599,7311,5777,11274,3664,8021,7297,9021,3669,1981,5335,817,3839,3665,6041,8086,1958,8672,567,8519,129401,3105,3383,3123,11097,5771,3662,5770,5580,5781,10379,2210,3717,3107,960,79902,3837,818,402569,4502,3460,10410,1973,3454,1982,4261,7316,7324,7175,816,9688,10437,3394,10581,3659	PTAFR,IRF3,PPM1B,FLNB,HLA-DPA1,PIAS1,PSMB8,NUP210,SP100,SOCS1,FCGR1A,TRIM25,NUP133,PIN1,ADAR,EIF4E,SEH1L,CAMK2A,MX1,UBA52,PTPN6,USP18,IRF6,NUP214,TYK2,SOCS3,ISG20,EIF4G1,PLCG1,CAMK2D,KPNA3,IRF7,RNASEL,AAAS,EGR1,EIF4G3,B2M,IFITM1,NUP35,HLA-A,ICAM1,HLA-DRB1,NUPL2,PTPN2,IRF4,PTPN1,PRKCD,PTPN11,IRF9,FCGR1B,JAK2,HLA-C,CD44,NUP85,KPNB1,CAMK2G,KPNA7,MT2A,IFNGR2,IFITM3,EIF4A1,IFNAR1,EIF4G2,CIITA,UBC,UBE2E1,TPR,CAMK2B,NUP93,IFI30,IRF8,IFITM2,IRF1
REACT_169333	TRP channels	0.729811849394758	-0.314968518615631	25	10	0.00316155548529877	3163	7167	54822,7226,79054,162514,80036,56302,57113,59341,7442,29850	TRPM7,TRPM2,TRPM8,TRPV3,TRPM3,TRPV5,TRPC7,TRPV4,TRPV1,TRPM5
REACT_120801	Abacavir transmembrane transport	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	6582,6581	SLC22A2,SLC22A3
5416731	Disease	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5417131	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_6934	LDL-mediated lipid transport	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	4018,3949	LPA,LDLR
REACT_831	Cytochrome c-mediated apoptotic response	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	54205,317	CYCS,APAF1
5709965	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_2156	Cleavage of the damaged pyrimidine	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	4913,8930	NTHL1,MBD4
REACT_25210	N-glycan trimming and elongation in the cis-Golgi	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	79694,4245	MANEA,MGAT1
REACT_2141	Assembly of the RAD51-ssDNA nucleoprotein complex	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	6118,5893	RPA2,RAD52
5417129	Signaling by NOTCH1 in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5709968	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5709963	Signaling by NOTCH1	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_1405	Depyrimidination	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	4913,8930	NTHL1,MBD4
REACT_1887	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	35,3033	ACADS,HADH
REACT_1525	PKA-mediated phosphorylation of key metabolic factors	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	5566,5567	PRKACA,PRKACB
REACT_607	Activation of caspases through apoptosome-mediated cleavage	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	54205,317	CYCS,APAF1
REACT_1249	Histidine catabolism	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	10841,131669	FTCD,UROC1
5417130	FBXW7 Mutants and NOTCH1 in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_1573	Extrinsic Pathway	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	2159,2155	F10,F7
REACT_22394	Synthesis of UDP-N-acetyl-glucosamine	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	9945,6675	GFPT2,UAP1
REACT_1194	Activation of NOXA and translocation to mitochondria	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	5366,7027	PMAIP1,TFDP1
REACT_15439	Serotonin and melatonin biosynthesis	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	1644,15	DDC,AANAT
5417133	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_6323	Host Interactions with Influenza Factors	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	10898,8106	CPSF4,PABPN1
5709966	Signaling by NOTCH1 in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_12541	NOSTRIN mediated eNOS trafficking	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	857,1785	CAV1,DNM2
REACT_121	Activation of PUMA and translocation to mitochondria	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	27113,7027	BBC3,TFDP1
5416817	Signal Transduction	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5709964	Signaling by NOTCH	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5311370	Collagen degradation	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	4318,4313	MMP9,MMP2
5417125	Activated NOTCH1 Transmits Signal to the Nucleus	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_9518	Digestion of dietary lipid	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	1056,1208	CEL,CLPS
5709962	Activated NOTCH1 Transmits Signal to the Nucleus	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_1482	ERK activation	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	983,5605	CDK1,MAP2K2
REACT_163679	Scavenging by Class B Receptors	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	949,948	SCARB1,CD36
5417127	Signaling by NOTCH	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_121388	Abacavir metabolism	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	2987,5105	GUK1,PCK1
REACT_1201	Processing of DNA ends prior to end rejoining	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	5591,7520	PRKDC,XRCC5
5709658	Disease	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_702	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	4913,8930	NTHL1,MBD4
5709970	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5417132	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_118778	Activation of RAS in B Cells	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	3845,3265	KRAS,HRAS
5709969	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_16963	Tachykinin receptors bind tachykinins	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	6865,6870	TACR2,TACR3
5417126	Signaling by NOTCH1	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5709967	FBXW7 Mutants and NOTCH1 in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_164006	Sperm:Oocyte Membrane Binding	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	113177,928	IZUMO4,CD9
5709719	Signal Transduction	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
5417128	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.730698706216252	-0.313754070795193	5	2	0.000632311097059753	3163	7167	7311,7316	UBA52,UBC
REACT_13648	Regulation of Apoptosis	0.73347386187739	-0.309963316829686	61	25	0.00790388871324692	3163	7167	5689,7311,5684,5692,1630,5721,5710,9491,5685,7316,1613,5704,23604,5699,122706,5696,5687,5709,5714,5701,10213,10197,90249,219699,5686	PSMB1,UBA52,PSMA3,PSMB4,DCC,PSME2,PSMD4,PSMF1,PSMA4,UBC,DAPK3,PSMC4,DAPK2,PSMB10,PSMB11,PSMB8,PSMA6,PSMD3,PSMD8,PSMC2,PSMD14,PSME3,UNC5A,UNC5B,PSMA5
REACT_2222	Dual incision reaction in TC-NER	0.737484308738164	-0.304510467281741	30	12	0.00379386658235852	3163	7167	2967,2067,5438,902,5441,5439,2968,5440,56949,5434,5437,2072	GTF2H3,ERCC1,POLR2I,CCNH,POLR2L,POLR2J,GTF2H4,POLR2K,XAB2,POLR2E,POLR2H,ERCC4
REACT_15457	G-protein activation	0.737484308738164	-0.304510467281741	30	12	0.00379386658235852	3163	7167	2781,2793,59345,2788,346562,2786,2782,2779,51764,2771,2783,548645	GNAZ,GNGT2,GNB4,GNG7,GNAT3,GNG4,GNB1,GNAT1,GNG13,GNAI2,GNB2,DNAJC25
REACT_1941	Formation of transcription-coupled NER (TC-NER) repair complex	0.737484308738164	-0.304510467281741	30	12	0.00379386658235852	3163	7167	2967,2067,5438,902,5441,5439,2968,5440,56949,5434,5437,2072	GTF2H3,ERCC1,POLR2I,CCNH,POLR2L,POLR2J,GTF2H4,POLR2K,XAB2,POLR2E,POLR2H,ERCC4
REACT_6296	Export of Viral Ribonucleoproteins from Nucleus	0.737484308738164	-0.304510467281741	30	12	0.00379386658235852	3163	7167	11097,7175,23225,7514,55746,9688,8021,79902,81929,129401,8086,3304	NUPL2,TPR,NUP210,XPO1,NUP133,NUP93,NUP214,NUP85,SEH1L,NUP35,AAAS,HSPA1B
REACT_309	Stabilization of p53	0.738160216996922	-0.303594381741844	54	22	0.00695542206765729	3163	7167	5689,7311,5684,5692,5721,5710,9491,5685,7316,5704,64326,5699,5687,122706,5696,5709,5714,5701,10213,472,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,PSMD4,PSMF1,PSMA4,UBC,PSMC4,RFWD2,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,PSMD14,ATM,PSME3,PSMA5
REACT_169274	Cellular Senescence	0.740385425263625	-0.300584383425728	197	83	0.0262409105279798	3163	7167	9134,126961,3397,29855,6195,8349,8358,1026,1432,8290,898,5606,3490,54386,64682,6196,4001,4790,51343,26277,10393,6045,51434,1032,3017,7311,8370,2077,1019,79813,8550,1871,85236,23466,3021,8697,8881,3576,8337,128312,8338,3020,1870,25913,3006,27327,8091,51433,57634,50488,57690,8970,2113,3725,57332,5601,653604,5600,6774,6667,23135,5609,7867,22955,2353,7324,7316,1051,9261,10919,2114,996,3005,7027,10111,472,23523,3159,4217,11065,7013,333932,29945	CCNE2,HIST2H3C,ID1,UBN1,RPS6KA1,HIST2H2BE,HIST1H3B,CDKN1A,MAPK14,HIST3H3,CCNE1,MAP2K3,IGFBP7,TERF2IP,ANAPC1,RPS6KA2,LMNB1,NFKB1,FZR1,TINF2,ANAPC10,RNF2,ANAPC7,CDKN2D,HIST1H2BD,UBA52,HIST2H4A,ERF,CDK4,EHMT1,MAPKAPK5,E2F3,HIST1H2BK,CBX6,H3F3B,CDC23,CDC16,IL8,HIST2H2AA3,HIST3H2BB,HIST2H2AC,H3F3A,E2F2,POT1,HIST1H1C,TNRC6A,HMGA2,ANAPC5,EP400,MINK1,TNRC6C,HIST1H2BJ,ETS1,JUN,CBX8,MAPK9,HIST2H3D,MAPK11,STAT3,SP1,KDM6B,MAP2K7,MAPKAPK3,SCMH1,FOS,UBE2E1,UBC,CEBPB,MAPKAPK2,EHMT2,ETS2,CDC27,H1F0,TFDP1,RAD50,ATM,CABIN1,HMGA1,MAP3K5,UBE2C,TERF1,HIST2H3A,ANAPC4
REACT_12555	Downstream TCR signaling	0.744395215701143	-0.295183181288506	47	19	0.00600695542206766	3163	7167	5170,7189,920,3635,387522,5295,10892,3113,3123,8517,23118,919,4792,4790,5296,3551,5290,646626,6885	PDPK1,TRAF6,CD4,INPP5D,TMEM189-UBE2V1,PIK3R1,MALT1,HLA-DPA1,HLA-DRB1,IKBKG,TAB2,CD247,NFKBIA,NFKB1,PIK3R2,IKBKB,PIK3CA,LOC646626,MAP3K7
REACT_1835	Transport of Mature mRNA Derived from an Intronless Transcript	0.745215554254989	-0.294081767881298	35	14	0.00442617767941827	3163	7167	11097,7175,23225,29894,10189,55746,9688,22916,8021,1977,79902,81929,129401,8086	NUPL2,TPR,NUP210,CPSF1,ALYREF,NUP133,NUP93,NCBP2,NUP214,EIF4E,NUP85,SEH1L,NUP35,AAAS
REACT_1949	CDT1 association with the CDC6:ORC:origin complex	0.74694572861288	-0.291762748947968	59	24	0.00758773316471704	3163	7167	5689,4999,7311,5684,5692,5721,81620,990,5710,9491,5685,7316,5704,5699,5687,122706,5696,5709,5714,5701,84515,10213,10197,5686	PSMB1,ORC2,UBA52,PSMA3,PSMB4,PSME2,CDT1,CDC6,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMA6,PSMB11,PSMB8,PSMD3,PSMD8,PSMC2,MCM8,PSMD14,PSME3,PSMA5
REACT_25351	TRAF6 mediated induction of TAK1 complex	0.751489522604406	-0.285698011863137	18	7	0.00221308883970914	3163	7167	23098,7189,929,7311,6885,23118,7316	SARM1,TRAF6,CD14,UBA52,MAP3K7,TAB2,UBC
REACT_6818	Assembly Of The HIV Virion	0.751489522604406	-0.285698011863137	18	7	0.00221308883970914	3163	7167	7251,51160,155382,7311,55048,7316,5045	TSG101,VPS28,VPS37D,UBA52,VPS37C,UBC,FURIN
REACT_18342	Nucleotide-like (purinergic) receptors	0.751489522604406	-0.285698011863137	18	7	0.00221308883970914	3163	7167	5028,136,134,2840,10161,5029,5032	P2RY1,ADORA2B,ADORA1,GPR17,LPAR6,P2RY2,P2RY11
REACT_329	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.752634859991354	-0.284175082481009	13	5	0.00158077774264938	3163	7167	5515,28227,5558,5518,7027	PPP2CA,PPP2R3B,PRIM2,PPP2R1A,TFDP1
REACT_9413	FGFR2c ligand binding and activation	0.752634859991354	-0.284175082481009	13	5	0.00158077774264938	3163	7167	2246,2254,2249,26281,8817	FGF1,FGF9,FGF4,FGF20,FGF18
REACT_172631	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.752634859991354	-0.284175082481009	13	5	0.00158077774264938	3163	7167	1211,161,1212,7855,160	CLTA,AP2A2,CLTB,FZD5,AP2A1
REACT_1597	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.752684573551138	-0.284109031968813	52	21	0.00663926651912741	3163	7167	6431,10250,9939,10921,4799,8021,129401,6426,11097,7175,23225,6427,10189,55746,9688,22916,1977,79902,81929,9785,8086	SRSF6,SRRM1,RBM8A,RNPS1,NFX1,NUP214,NUP35,SRSF1,NUPL2,TPR,NUP210,SRSF2,ALYREF,NUP133,NUP93,NCBP2,EIF4E,NUP85,SEH1L,DHX38,AAAS
REACT_118700	Antigen Activates B Cell Receptor Leading to Generation of Second Messengers	0.752684573551138	-0.284109031968813	52	21	0.00663926651912741	3163	7167	4690,974,5295,868,3710,867,4067,29760,30011,640,7409,5335,973,2534,6464,5336,3708,27071,84876,6725,6850	NCK1,CD79B,PIK3R1,CBLB,ITPR3,CBL,LYN,BLNK,SH3KBP1,BLK,VAV1,PLCG1,CD79A,FYN,SHC1,PLCG2,ITPR1,DAPP1,ORAI1,SRMS,SYK
REACT_23832	Nephrin interactions	0.754390437550592	-0.28184522331243	23	9	0.00284539993676889	3163	7167	2534,4690,5296,5295,5290,81,87,88,55243	FYN,NCK1,PIK3R2,PIK3R1,PIK3CA,ACTN4,ACTN1,ACTN2,KIRREL
REACT_1913	RNA Polymerase I Promoter Escape	0.754390437550592	-0.28184522331243	23	9	0.00284539993676889	3163	7167	9015,2967,902,9014,2968,6908,79101,5440,5437	TAF1A,GTF2H3,CCNH,TAF1B,GTF2H4,TBP,TAF1D,POLR2K,POLR2H
REACT_19118	SLC-mediated transmembrane transport	0.763914298404185	-0.269299670971319	254	107	0.0338286436926968	3163	7167	6582,56606,6581,64924,1951,6528,29988,85413,9152,6513,9123,9197,6574,51458,80024,28232,27173,57835,55630,23225,55746,5002,83697,23446,57127,56301,1836,57181,57468,6512,81929,6584,6578,6559,142680,348932,81539,6531,65010,115019,26503,8021,23539,2645,2542,6575,9497,169026,29985,23428,8086,9356,10723,80736,254428,10861,6538,6522,6523,6549,9057,129401,7780,9154,6534,11097,6509,28965,55315,1468,6521,6548,10999,55117,353189,3101,6558,79902,26266,9498,206358,81031,345274,92579,7175,28231,6533,283652,222962,160728,11136,6550,8140,3099,6508,9688,6569,340024,3098,9153,7779,10991,6571,124935,6583,121260,155184	SLC22A2,SLC2A9,SLC22A3,SLC30A5,CELSR3,SLC5A5,SLC2A8,SLC22A16,SLC6A5,SLC2A1,SLC16A3,SLC33A1,SLC20A1,RHCG,SLC8B1,SLCO3A1,SLC39A1,SLC4A5,SLC39A4,NUP210,NUP133,SLC22A18,SLC4A9,SLC44A1,RHBG,SLC7A10,SLC26A2,SLC39A10,SLC12A5,SLC1A7,SEH1L,SLC22A5,SLCO2A1,SLC12A3,SLC34A3,SLC6A18,SLC38A1,SLC6A3,SLC26A6,SLC26A9,SLC17A5,NUP214,SLC16A8,GCK,SLC37A4,SLC20A2,SLC4A7,SLC30A8,SLC39A3,SLC7A8,AAAS,SLC22A6,SLC12A7,SLC44A4,SLC41A1,SLC26A1,SLC6A11,SLC4A2,SLC5A1,SLC9A2,SLC7A6,NUP35,SLC30A2,SLC28A1,SLC6A7,NUPL2,SLC1A4,SLC27A6,SLC29A3,SLC25A10,SLC4A1,SLC9A1,SLC27A4,SLC6A15,SLCO4C1,HK3,SLC12A2,NUP85,SLC13A4,SLC4A8,SLC36A1,SLC2A10,SLC10A6,G6PC3,TPR,SLCO4A1,SLC6A6,SLC24A5,SLC29A4,SLC5A8,SLC7A9,SLC9A3,SLC7A5,HK2,SLC4A3,NUP93,SLC34A1,SLC6A19,HK1,SLC28A2,SLC30A1,SLC38A3,SLC18A2,SLC43A2,SLC22A4,SLC15A4,SLC2A7
REACT_405	Transport of the SLBP Dependant Mature mRNA	0.764528397790414	-0.268496108730089	33	13	0.0041100221308884	3163	7167	11097,7175,23225,10189,55746,9688,22916,1977,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,ALYREF,NUP133,NUP93,NCBP2,EIF4E,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_16973	Orexin and neuropeptides FF and QRFP bind to their respective receptors	0.764859558802579	-0.268063045273674	8	3	0.00094846664558963	3163	7167	64106,347148,8620	NPFFR1,QRFP,NPFF
REACT_1541	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.764859558802579	-0.268063045273674	8	3	0.00094846664558963	3163	7167	35,3033,37	ACADS,HADH,ACADVL
REACT_11068	Nef and signal transduction	0.764859558802579	-0.268063045273674	8	3	0.00094846664558963	3163	7167	2534,1794,919	FYN,DOCK2,CD247
REACT_23950	Interleukin-1 processing	0.764859558802579	-0.268063045273674	8	3	0.00094846664558963	3163	7167	3606,4791,4790	IL18,NFKB2,NFKB1
REACT_160086	Regulation of actin dynamics for phagocytic cup formation	0.766836679949996	-0.265481433860817	81	33	0.0104331331014859	3163	7167	10163,10810,71,1793,10096,7410,4627,4650,7409,25,55845,63916,10092,2209,919,51517,3320,6850,1072,5058,10451,4690,3326,7456,5747,26999,10552,10458,2214,7454,3984,2212,60	WASF2,WASF3,ACTG1,DOCK1,ACTR3,VAV2,MYH9,MYO9B,VAV1,ABL1,BRK1,ELMO2,ARPC5,FCGR1A,CD247,NCKIPSD,HSP90AA1,SYK,CFL1,PAK1,VAV3,NCK1,HSP90AB1,WIPF1,PTK2,CYFIP2,ARPC1A,BAIAP2,FCGR3A,WAS,LIMK1,FCGR2A,ACTB
REACT_13464	Regulation of activated PAK-2p34 by proteasome mediated degradation	0.767402947597661	-0.264743260158078	50	20	0.00632311097059753	3163	7167	5689,7311,5684,5692,5721,5710,9491,5685,7316,5704,5699,5696,5687,122706,5714,5709,5701,10213,10197,5686	PSMB1,UBA52,PSMA3,PSMB4,PSME2,PSMD4,PSMF1,PSMA4,UBC,PSMC4,PSMB10,PSMB8,PSMA6,PSMB11,PSMD8,PSMD3,PSMC2,PSMD14,PSME3,PSMA5
REACT_6233	Transcription of the HIV genome	0.768072893323037	-0.263870637157399	62	25	0.00790388871324692	3163	7167	9150,2967,6881,5438,902,6923,5441,6908,5440,6924,6921,7469,8178,2961,6827,5439,2957,2968,904,1025,6874,5434,22916,5437,25920	CTDP1,GTF2H3,TAF10,POLR2I,CCNH,TCEB2,POLR2L,TBP,POLR2K,TCEB3,TCEB1,NELFA,ELL,GTF2E2,SUPT4H1,POLR2J,GTF2A1,GTF2H4,CCNT1,CDK9,TAF4,POLR2E,NCBP2,POLR2H,NELFB
REACT_15550	Insulin Processing	0.781440079749065	-0.246616805445873	26	10	0.00316155548529877	3163	7167	64924,56605,6804,149371,3800,55770,23265,723961,1363,3630	SLC30A5,ERO1LB,STX1A,EXOC8,KIF5C,EXOC2,EXOC7,INS-IGF2,CPE,INS
REACT_115831	ISG15 antiviral mechanism	0.782074148850753	-0.245805723429669	72	29	0.00916851090736642	3163	7167	4599,402569,7311,11274,8672,1973,3661,5495,8021,1982,7324,2317,129401,7316,11097,7175,5335,1981,23225,3839,7706,55746,5300,9688,1977,79902,81929,3837,8086	MX1,KPNA7,UBA52,USP18,EIF4G3,EIF4A1,IRF3,PPM1B,NUP214,EIF4G2,UBE2E1,FLNB,NUP35,UBC,NUPL2,TPR,PLCG1,EIF4G1,NUP210,KPNA3,TRIM25,NUP133,PIN1,NUP93,EIF4E,NUP85,SEH1L,KPNB1,AAAS
REACT_115676	Antiviral mechanism by IFN-stimulated genes	0.782074148850753	-0.245805723429669	72	29	0.00916851090736642	3163	7167	4599,402569,7311,11274,8672,1973,3661,5495,8021,1982,7324,2317,129401,7316,11097,7175,5335,1981,23225,3839,7706,55746,5300,9688,1977,79902,81929,3837,8086	MX1,KPNA7,UBA52,USP18,EIF4G3,EIF4A1,IRF3,PPM1B,NUP214,EIF4G2,UBE2E1,FLNB,NUP35,UBC,NUPL2,TPR,PLCG1,EIF4G1,NUP210,KPNA3,TRIM25,NUP133,PIN1,NUP93,EIF4E,NUP85,SEH1L,KPNB1,AAAS
REACT_169208	Glycogen synthesis	0.782602750042825	-0.245130055229345	16	6	0.00189693329117926	3163	7167	2997,2632,5236,7311,7360,7316	GYS1,GBE1,PGM1,UBA52,UGP2,UBC
REACT_15513	Amine-derived hormones	0.782602750042825	-0.245130055229345	16	6	0.00189693329117926	3163	7167	7173,389434,6528,1735,1644,15	TPO,IYD,SLC5A5,DIO3,DDC,AANAT
REACT_12002	ARMS-mediated activation	0.782602750042825	-0.245130055229345	16	6	0.00189693329117926	3163	7167	3845,983,3265,5894,5605,4914	KRAS,CDK1,HRAS,RAF1,MAP2K2,NTRK1
REACT_118595	Mitochondrial Protein Import	0.788184912570529	-0.238022556030256	53	21	0.00663926651912741	3163	7167	516,9804,80273,10165,4580,10452,7416,26519,2671,197257,134266,10469,3313,26517,291,10440,29928,56993,1537,498,10651	ATP5G1,TOMM20,GRPEL1,SLC25A13,MTX1,TOMM40,VDAC1,TIMM10,GFER,LDHD,GRPEL2,TIMM44,HSPA9,TIMM13,SLC25A4,TIMM17A,TIMM22,TOMM22,CYC1,ATP5A1,MTX2
REACT_338	Transport of Mature mRNAs Derived from Intronless Transcripts	0.788260617964715	-0.237926510346751	36	14	0.00442617767941827	3163	7167	11097,7175,23225,29894,10189,55746,9688,22916,8021,1977,79902,81929,129401,8086	NUPL2,TPR,NUP210,CPSF1,ALYREF,NUP133,NUP93,NCBP2,NUP214,EIF4E,NUP85,SEH1L,NUP35,AAAS
REACT_964	Intrinsic Pathway for Apoptosis	0.792662550230752	-0.232357683561761	41	16	0.00505848877647803	3163	7167	4836,578,90427,207,5366,10000,7027,10971,27113,7534,5533,54205,317,7531,637,2810	NMT1,BAK1,BMF,AKT1,PMAIP1,AKT3,TFDP1,YWHAQ,BBC3,YWHAZ,PPP3CC,CYCS,APAF1,YWHAE,BID,SFN
REACT_641	Dissolution of Fibrin Clot	0.79277048363656	-0.232221527188494	11	4	0.00126462219411951	3163	7167	5054,5345,5329,5055	SERPINE1,SERPINF2,PLAUR,SERPINB2
REACT_23988	Transport of organic anions	0.79277048363656	-0.232221527188494	11	4	0.00126462219411951	3163	7167	28231,6578,353189,28232	SLCO4A1,SLCO2A1,SLCO4C1,SLCO3A1
REACT_11059	Androgen biosynthesis	0.79277048363656	-0.232221527188494	11	4	0.00126462219411951	3163	7167	6716,51144,79644,3972	SRD5A2,HSD17B12,SRD5A3,LHB
REACT_1364	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.79277048363656	-0.232221527188494	11	4	0.00126462219411951	3163	7167	22916,6635,134353,6628	NCBP2,SNRPE,LSM11,SNRPB
REACT_15309	Acetylcholine Neurotransmitter Release Cycle	0.79277048363656	-0.232221527188494	11	4	0.00126462219411951	3163	7167	10815,6804,1103,5864	CPLX1,STX1A,CHAT,RAB3A
REACT_160125	Visual phototransduction	0.797227206195337	-0.226615564036482	94	38	0.0120139108441353	3163	7167	3292,4836,375790,3339,3949,6385,4647,336,6017,5948,2782,5949,5578,9249,6382,151056,3000,5145,388531,2978,2817,29967,157506,57016,8630,9672,9227,8787,2652,1208,728458,5959,121214,2779,64220,5158,6011,7804	HSD17B1,NMT1,AGRN,HSPG2,LDLR,SDC4,MYO7A,APOA2,RLBP1,RBP2,GNB1,RBP3,PRKCA,DHRS3,SDC1,PLB1,GUCY2D,PDE6A,RGS9BP,GUCA1A,GPC1,LRP12,RDH10,AKR1B10,HSD17B6,SDC3,LRAT,RGS9,OPN1MW,CLPS,OPN1MW2,RDH5,SDR9C7,GNAT1,STRA6,PDE6B,GRK1,LRP8
REACT_9441	Hexose transport	0.797337414373135	-0.226477334231868	46	18	0.00569079987353778	3163	7167	6513,92579,8021,6523,129401,11097,7175,23225,2542,2645,55746,3099,9688,3098,3101,79902,8086,81929	SLC2A1,G6PC3,NUP214,SLC5A1,NUP35,NUPL2,TPR,NUP210,SLC37A4,GCK,NUP133,HK2,NUP93,HK1,HK3,NUP85,AAAS,SEH1L
REACT_19327	G alpha (s) signalling events	0.79960419362227	-0.223638431719483	132	54	0.0170723996206133	3163	7167	7433,5745,6344,2782,5732,136,2492,10267,5143,2783,5139,3274,9340,1395,1816,10268,5136,2781,2793,10846,4157,2642,3362,109,112,51764,5144,2771,10381,113,2740,5739,2788,107,2786,5151,154,3973,5138,3360,548645,3363,59350,114,59345,111,3972,346562,594857,151306,117,7434,5032,1812	VIPR1,PTH1R,SCTR,GNB1,PTGER2,ADORA2B,FSHR,RAMP1,PDE4C,GNB2,PDE3A,HRH2,GLP2R,CRHR2,DRD5,RAMP3,PDE1A,GNAZ,GNGT2,PDE10A,MC1R,GCGR,HTR6,ADCY3,ADCY6,GNG13,PDE4D,GNAI2,TUBB3,ADCY7,GLP1R,PTGIR,GNG7,ADCY1,GNG4,PDE8A,ADRB2,LHCGR,PDE2A,HTR4,DNAJC25,HTR7,RXFP1,ADCY8,GNB4,ADCY5,LHB,GNAT3,NPS,GPBAR1,ADCYAP1R1,VIPR2,P2RY11,DRD1
REACT_6248	Transport of Ribonucleoproteins into the Host Nucleus	0.804728960487067	-0.217249753305199	29	11	0.00347771103382864	3163	7167	11097,7175,23225,55746,9688,8021,79902,81929,3837,129401,8086	NUPL2,TPR,NUP210,NUP133,NUP93,NUP214,NUP85,SEH1L,KPNB1,NUP35,AAAS
REACT_6179	NEP/NS2 Interacts with the Cellular Export Machinery	0.804728960487067	-0.217249753305199	29	11	0.00347771103382864	3163	7167	11097,7175,23225,7514,55746,9688,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,XPO1,NUP133,NUP93,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_6804	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.804728960487067	-0.217249753305199	29	11	0.00347771103382864	3163	7167	11097,7175,23225,2645,55746,9688,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,GCK,NUP133,NUP93,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_1281	Transport of Mature Transcript to Cytoplasm	0.806978821802296	-0.214457854176376	56	22	0.00695542206765729	3163	7167	6431,10250,9939,10921,4799,8021,129401,6426,11097,7175,29894,23225,6427,10189,55746,9688,22916,1977,79902,81929,9785,8086	SRSF6,SRRM1,RBM8A,RNPS1,NFX1,NUP214,NUP35,SRSF1,NUPL2,TPR,CPSF1,NUP210,SRSF2,ALYREF,NUP133,NUP93,NCBP2,EIF4E,NUP85,SEH1L,DHX38,AAAS
REACT_21330	Synthesis and interconversion of nucleotide di- and triphosphates	0.80749158484134	-0.213822645188741	19	7	0.00221308883970914	3163	7167	7296,6241,204,1841,2987,50484,1503	TXNRD1,RRM2,AK2,DTYMK,GUK1,RRM2B,CTPS1
REACT_163699	Scavenging by Class A Receptors	0.80749158484134	-0.213822645188741	19	7	0.00221308883970914	3163	7167	8685,811,117156,1284,78989,286133,1277	MARCO,CALR,SCGB3A2,COL4A2,COLEC11,SCARA5,COL1A1
REACT_19189	Synthesis, Secretion, and Deacylation of Ghrelin	0.80749158484134	-0.213822645188741	19	7	0.00221308883970914	3163	7167	23478,3952,723961,2688,9314,43,3630	SEC11A,LEP,INS-IGF2,GH1,KLF4,ACHE,INS
REACT_19305	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.812217972559212	-0.207986535731461	97	39	0.0123300663926652	3163	7167	6582,56606,6581,64924,29988,254428,85413,80736,9152,6513,9123,6538,51458,6523,27173,7780,6534,55630,5002,23446,57127,55117,57181,6584,26266,348932,6531,81031,345274,23539,6533,169026,340024,7779,29985,6571,6583,155184,9356	SLC22A2,SLC2A9,SLC22A3,SLC30A5,SLC2A8,SLC41A1,SLC22A16,SLC44A4,SLC6A5,SLC2A1,SLC16A3,SLC6A11,RHCG,SLC5A1,SLC39A1,SLC30A2,SLC6A7,SLC39A4,SLC22A18,SLC44A1,RHBG,SLC6A15,SLC39A10,SLC22A5,SLC13A4,SLC6A18,SLC6A3,SLC2A10,SLC10A6,SLC16A8,SLC6A6,SLC30A8,SLC6A19,SLC30A1,SLC39A3,SLC18A2,SLC22A4,SLC2A7,SLC22A6
REACT_524	SOS-mediated signalling	0.816133070720399	-0.203177860450382	14	5	0.00158077774264938	3163	7167	3845,983,3265,5894,5605	KRAS,CDK1,HRAS,RAF1,MAP2K2
REACT_18289	P2Y receptors	0.816133070720399	-0.203177860450382	14	5	0.00158077774264938	3163	7167	5028,2840,10161,5029,5032	P2RY1,GPR17,LPAR6,P2RY2,P2RY11
REACT_25162	Interferon alpha/beta signaling	0.816561737491426	-0.202652757070717	66	26	0.00822004426177679	3163	7167	4599,1958,10410,5777,11274,3661,3664,3454,7297,8519,3105,9021,3669,3662,5770,5696,8651,10379,5781,103,3665,6041,3394,3107,10581,3659	MX1,EGR1,IFITM3,PTPN6,USP18,IRF3,IRF6,IFNAR1,TYK2,IFITM1,HLA-A,SOCS3,ISG20,IRF4,PTPN1,PSMB8,SOCS1,IRF9,PTPN11,ADAR,IRF7,RNASEL,IRF8,HLA-C,IFITM2,IRF1
REACT_160102	Diseases associated with visual transduction	0.82119863219223	-0.196990259459508	95	38	0.0120139108441353	3163	7167	3292,4836,375790,3339,3949,6385,4647,336,6017,5948,2782,5949,5578,9249,6382,151056,3000,5145,388531,2978,2817,29967,157506,57016,8630,9672,9227,8787,2652,1208,728458,5959,121214,2779,64220,5158,6011,7804	HSD17B1,NMT1,AGRN,HSPG2,LDLR,SDC4,MYO7A,APOA2,RLBP1,RBP2,GNB1,RBP3,PRKCA,DHRS3,SDC1,PLB1,GUCY2D,PDE6A,RGS9BP,GUCA1A,GPC1,LRP12,RDH10,AKR1B10,HSD17B6,SDC3,LRAT,RGS9,OPN1MW,CLPS,OPN1MW2,RDH5,SDR9C7,GNAT1,STRA6,PDE6B,GRK1,LRP8
REACT_20661	CREB phosphorylation through the activation of CaMKK	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	1385,84254	CREB1,CAMKK1
REACT_7993	Telomere C-strand synthesis initiation	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	5426,5558	POLE,PRIM2
REACT_25073	Molybdenum cofactor biosynthesis	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	27304,10243	MOCS3,GPHN
REACT_17041	Vasopressin-like receptors	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	553,552	AVPR1B,AVPR1A
REACT_2244	DNA replication initiation	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	5426,5558	POLE,PRIM2
REACT_111247	Klotho-mediated ligand binding	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	2264,2260	FGFR4,FGFR1
REACT_150201	Synthesis of 12-eicosatetraenoic acid derivatives	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	2876,2879	GPX1,GPX4
REACT_118722	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	4851,4853	NOTCH1,NOTCH2
REACT_15408	Cam-PDE 1 activation	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	5136,5137	PDE1A,PDE1C
REACT_121006	Acyl chain remodeling of CL	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	5321,8398	PLA2G4A,PLA2G6
REACT_408	Presynaptic phase of homologous DNA pairing and strand exchange	0.825593220772862	-0.191653095561732	6	2	0.000632311097059753	3163	7167	6118,5893	RPA2,RAD52
REACT_13806	Ceramide signalling	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	4804	NGFR
REACT_15297	Regulation of thyroid hormone activity	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	1735	DIO3
REACT_9484	FGFR1c and Klotho ligand binding and activation	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	2260	FGFR1
REACT_1391	ERK1 activation	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	983	CDK1
175567	Integration of viral DNA into host genomic DNA	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	3159	HMGA1
REACT_2100	Activation of BMF and translocation to mitochondria	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	90427	BMF
REACT_6743	Inhibition of TSC complex formation by PKB	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	7249	TSC2
REACT_2055	Processing of DNA double-strand break ends	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	6118	RPA2
REACT_25168	GABA A (rho) receptor activation	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	2570	GABRR2
REACT_75815	Potassium transport channels	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	3766	KCNJ10
REACT_75927	The NLRP1 inflammasome	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	22861	NLRP1
REACT_13781	Trafficking of dietary sterols	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	29881	NPC1L1
REACT_111046	betaKlotho-mediated ligand binding	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	2264	FGFR4
REACT_163785	Hydroxycarboxylic acid-binding receptors	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	338442	HCAR2
REACT_75819	TWIK related potassium channel (TREK)	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	3776	KCNK2
REACT_59	Utilization of Ketone Bodies	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	622	BDH1
REACT_22166	Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	10644	IGF2BP2
REACT_6866	Autointegration results in viral DNA circles	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	3159	HMGA1
REACT_150128	Electron Transport from NADPH to Ferredoxin	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	2232	FDXR
REACT_2032	Synthesis of dolichyl-phosphate mannose	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	54344	DPM3
REACT_6362	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	983	CDK1
REACT_2025	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	37	ACADVL
REACT_8016	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.825688379580063	-0.191537841074205	3	1	0.000316155548529877	3163	7167	291	SLC25A4
REACT_25064	Destabilization of mRNA by Tristetraprolin (TTP)	0.83603365583894	-0.179086408527224	17	6	0.00189693329117926	3163	7167	9261,55802,54512,167227,56915,3842	MAPKAPK2,DCP1A,EXOSC4,DCP2,EXOSC5,TNPO1
REACT_326	Intrinsic Pathway	0.83603365583894	-0.179086408527224	17	6	0.00189693329117926	3163	7167	7450,2815,2812,2147,2159,5547	VWF,GP9,GP1BB,F2,F10,PRCP
REACT_19241	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.837018735901228	-0.177908824153913	122	49	0.015491621877964	3163	7167	9612,2180,27242,133522,6256,336,25942,6095,400569,55090,3995,85441,3157,84246,9441,29841,7004,6720,54578,9443,9572,55588,90390,10499,10498,3156,6667,2222,7296,80205,9439,79718,8841,2274,10025,948,51129,9969,57761,4800,183,50486,51586,406,9440,6907,2101,96764,2168	NCOR2,ACSL1,TNFRSF21,PPARGC1B,RXRA,APOA2,SIN3A,RORA,MED11,MED9,FADS3,HELZ2,HMGCS1,MED10,MED26,GRHL1,TEAD4,SREBF1,UGT1A6,MED7,NR1D1,MED29,MED30,NCOA2,CARM1,HMGCR,SP1,FDFT1,TXNRD1,CHD9,MED23,TBL1XR1,HDAC3,FHL2,MED16,CD36,ANGPTL4,MED13,TRIB3,NFYA,AGT,G0S2,MED15,ARNTL,MED17,TBL1X,ESRRA,TGS1,FABP1
REACT_150353	Mitochondrial Iron-Sulfur Cluster Biogenesis	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	81894,23479,2232	SLC25A28,ISCU,FDXR
REACT_19314	Sodium/Proton exchangers	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	6548,6549,6550	SLC9A1,SLC9A2,SLC9A3
REACT_847	Urea cycle	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	384,445,435	ARG2,ASS1,ASL
REACT_115828	Downregulation of ERBB4 signaling	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	11059,7311,7316	WWP1,UBA52,UBC
REACT_11082	Import of palmitoyl-CoA into the mitochondrial matrix	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	5563,51422,5565	PRKAA2,PRKAG2,PRKAB2
REACT_17017	Beta-oxidation of pristanoyl-CoA	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	3295,1384,8310	HSD17B4,CRAT,ACOX3
REACT_1786	Phenylalanine and tyrosine catabolism	0.838062068071651	-0.176663114331594	9	3	0.00094846664558963	3163	7167	2954,883,5092	GSTZ1,CCBL1,PCBD1
REACT_22393	Respiratory electron transport	0.839999221853611	-0.174354313509956	79	31	0.00980082200442618	3163	7167	4729,1350,4712,6391,27089,29796,4726,4697,1327,54205,1345,51079,2109,374291,6390,2110,4695,440567,126328,9167,1351,7385,9377,4715,4731,4728,1537,4700,4713,4720,1340	NDUFV2,COX7C,NDUFB6,SDHC,UQCRQ,UQCR10,NDUFS6,NDUFA4,COX4I1,CYCS,COX6C,NDUFA13,ETFB,NDUFS7,SDHB,ETFDH,NDUFA2,UQCRHL,NDUFA11,COX7A2L,COX8A,UQCRC2,COX5A,NDUFB9,NDUFV3,NDUFS8,CYC1,NDUFA6,NDUFB7,NDUFS2,COX6B1
REACT_25060	Iron uptake and transport	0.843014636302333	-0.170770958969279	40	15	0.00474233322794815	3163	7167	533,10312,127124,90423,55240,527,528,51606,3162,28982,8992,9114,7037,525,9550	ATP6V0B,TCIRG1,ATP6V1G3,ATP6V1E2,STEAP3,ATP6V0C,ATP6V1C1,ATP6V1H,HMOX1,FLVCR1,ATP6V0E1,ATP6V0D1,TFRC,ATP6V1B1,ATP6V1G1
REACT_116105	Glycosphingolipid metabolism	0.843014636302333	-0.170770958969279	40	15	0.00474233322794815	3163	7167	129807,2581,340075,6609,64781,2629,285362,5660,55627,79642,411,153642,4758,2760,410	NEU4,GALC,ARSI,SMPD1,CERK,GBA,SUMF1,PSAP,SMPD4,ARSJ,ARSB,ARSK,NEU1,GM2A,ARSA
REACT_20547	Metal ion SLC transporters	0.846720163013202	-0.16638502497247	25	9	0.00284539993676889	3163	7167	55630,64924,254428,169026,7779,29985,57181,27173,7780	SLC39A4,SLC30A5,SLC41A1,SLC30A8,SLC30A1,SLC39A3,SLC39A10,SLC39A1,SLC30A2
REACT_21346	Activation of Ca-permeable Kainate Receptor	0.852189144359145	-0.159946776369737	12	4	0.00126462219411951	3163	7167	2900,83988,1739,2899	GRIK4,NCALD,DLG1,GRIK3
REACT_111176	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.852189144359145	-0.159946776369737	12	4	0.00126462219411951	3163	7167	5593,5805,3320,207	PRKG2,PTS,HSP90AA1,AKT1
REACT_13645	Eicosanoids	0.852189144359145	-0.159946776369737	12	4	0.00126462219411951	3163	7167	57834,66002,5740,6916	CYP4F11,CYP4F12,PTGIS,TBXAS1
REACT_21322	Ionotropic activity of Kainate Receptors	0.852189144359145	-0.159946776369737	12	4	0.00126462219411951	3163	7167	2900,83988,1739,2899	GRIK4,NCALD,DLG1,GRIK3
REACT_25208	N-glycan antennae elongation in the medial/trans-Golgi	0.853202535905479	-0.158758320160715	20	7	0.00221308883970914	3163	7167	4248,4122,2683,6484,8703,8702,11282	MGAT3,MAN2A2,B4GALT1,ST3GAL4,B4GALT3,B4GALT4,MGAT4B
REACT_163701	FCERI mediated MAPK activation	0.860239110642983	-0.150544892747952	53	20	0.00632311097059753	3163	7167	5058,10451,27040,5609,5894,7410,3845,3937,2353,4067,983,5605,7409,3725,5335,6464,5336,5601,6850,3265	PAK1,VAV3,LAT,MAP2K7,RAF1,VAV2,KRAS,LCP2,FOS,LYN,CDK1,MAP2K2,VAV1,JUN,PLCG1,SHC1,PLCG2,MAPK9,SYK,HRAS
REACT_765	Mitotic Prophase	0.862820890623841	-0.147548152168877	133	53	0.0167562440720835	3163	7167	126961,2029,8349,8358,8970,891,8290,4000,129401,11097,23225,4001,10783,2010,5518,55746,387893,81876,653604,79648,3017,79902,81929,7112,8615,8370,140609,23133,85236,3021,26003,10592,5861,8021,983,84930,221496,5515,7175,2801,6418,7444,9688,8337,3020,8338,10776,128312,7443,54892,55844,333932,8086	HIST2H3C,ENSA,HIST2H2BE,HIST1H3B,HIST1H2BJ,CCNB1,HIST3H3,LMNA,NUP35,NUPL2,NUP210,LMNB1,NEK6,EMD,PPP2R1A,NUP133,SETD8,RAB1B,HIST2H3D,MCPH1,HIST1H2BD,NUP85,SEH1L,TMPO,USO1,HIST2H4A,NEK7,PHF8,HIST1H2BK,H3F3B,GORASP2,SMC2,RAB1A,NUP214,CDK1,MASTL,LEMD2,PPP2CA,TPR,GOLGA2,SET,VRK2,NUP93,HIST2H2AA3,H3F3A,HIST2H2AC,ARPP19,HIST3H2BB,VRK1,NCAPG2,PPP2R2D,HIST2H3A,AAAS
REACT_6759	Formation of ATP by chemiosmotic coupling	0.865782936877524	-0.144121052094628	15	5	0.00158077774264938	3163	7167	516,521,514,498,10476	ATP5G1,ATP5I,ATP5E,ATP5A1,ATP5H
REACT_15443	GRB2:SOS provides linkage to MAPK signaling for Intergrins	0.865782936877524	-0.144121052094628	15	5	0.00158077774264938	3163	7167	7450,5747,2335,7094,6714	VWF,PTK2,FN1,TLN1,SRC
REACT_13621	HDL-mediated lipid transport	0.865782936877524	-0.144121052094628	15	5	0.00158077774264938	3163	7167	3931,949,81693,9619,649	LCAT,SCARB1,AMN,ABCG1,BMP1
REACT_25085	N-Glycan antennae elongation	0.865782936877524	-0.144121052094628	15	5	0.00158077774264938	3163	7167	2683,6484,8703,8702,11282	B4GALT1,ST3GAL4,B4GALT3,B4GALT4,MGAT4B
REACT_16957	Peroxisomal lipid metabolism	0.868157182858328	-0.141382494473608	23	8	0.00252924438823901	3163	7167	1384,8443,23417,215,3295,84188,30,8310	CRAT,GNPAT,MLYCD,ABCD1,HSD17B4,FAR1,ACAA1,ACOX3
REACT_116145	PPARA Activates Gene Expression	0.868958420526153	-0.140460002357269	119	47	0.0148593107809042	3163	7167	2180,27242,133522,6256,336,6095,400569,55090,3995,85441,3157,84246,9441,29841,7004,6720,54578,9443,9572,55588,90390,10499,10498,3156,6667,2222,7296,80205,9439,79718,8841,2274,10025,948,51129,9969,57761,4800,183,50486,51586,406,9440,6907,2101,96764,2168	ACSL1,TNFRSF21,PPARGC1B,RXRA,APOA2,RORA,MED11,MED9,FADS3,HELZ2,HMGCS1,MED10,MED26,GRHL1,TEAD4,SREBF1,UGT1A6,MED7,NR1D1,MED29,MED30,NCOA2,CARM1,HMGCR,SP1,FDFT1,TXNRD1,CHD9,MED23,TBL1XR1,HDAC3,FHL2,MED16,CD36,ANGPTL4,MED13,TRIB3,NFYA,AGT,G0S2,MED15,ARNTL,MED17,TBL1X,ESRRA,TGS1,FABP1
REACT_160158	Role of phospholipids in phagocytosis	0.871717855229701	-0.137289467946553	46	17	0.0053746443250079	3163	7167	5295,5338,3710,2214,5335,2209,919,5580,3708,5296,5336,5290,2212,5337,122618,6850,8398	PIK3R1,PLD2,ITPR3,FCGR3A,PLCG1,FCGR1A,CD247,PRKCD,ITPR1,PIK3R2,PLCG2,PIK3CA,FCGR2A,PLD1,PLD4,SYK,PLA2G6
REACT_24968	Retinoid metabolism and transport	0.872063916727443	-0.136892558760037	41	15	0.00474233322794815	3163	7167	375790,3339,1208,3949,6385,57016,336,5948,9672,6382,151056,7804,9227,2817,29967	AGRN,HSPG2,CLPS,LDLR,SDC4,AKR1B10,APOA2,RBP2,SDC3,SDC1,PLB1,LRP8,LRAT,GPC1,LRP12
REACT_7991	Vpr-mediated nuclear import of PICs	0.876266314677821	-0.132085222058794	31	11	0.00347771103382864	3163	7167	11097,7175,23225,55746,9688,3159,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,NUP133,NUP93,HMGA1,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_197	Branched-chain amino acid catabolism	0.878305722467695	-0.129760542689541	18	6	0.00189693329117926	3163	7167	26275,4329,594,64087,56922,11112	HIBCH,ALDH6A1,BCKDHB,MCCC2,MCCC1,HIBADH
REACT_111158	ABCA transporters in lipid homeostasis	0.878305722467695	-0.129760542689541	18	6	0.00189693329117926	3163	7167	5824,215,5825,10347,9619,20	PEX19,ABCD1,ABCD3,ABCA7,ABCG1,ABCA2
REACT_163848	Reproduction	0.881280207104317	-0.126379647877938	26	9	0.00284539993676889	3163	7167	113177,347732,84329,57829,157855,928,2683,7784,378807	IZUMO4,CATSPER3,HVCN1,ZP4,KCNU1,CD9,B4GALT1,ZP3,CATSPER4
REACT_163914	Fertilization	0.881280207104317	-0.126379647877938	26	9	0.00284539993676889	3163	7167	113177,347732,84329,57829,157855,928,2683,7784,378807	IZUMO4,CATSPER3,HVCN1,ZP4,KCNU1,CD9,B4GALT1,ZP3,CATSPER4
REACT_6757	Interactions of Vpr with host cellular proteins	0.888420957167448	-0.118309597452337	34	12	0.00379386658235852	3163	7167	11097,7175,23225,291,55746,9688,3159,8021,79902,81929,129401,8086	NUPL2,TPR,NUP210,SLC25A4,NUP133,NUP93,HMGA1,NUP214,NUP85,SEH1L,NUP35,AAAS
REACT_1022	Nonhomologous End-joining (NHEJ)	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	5591,7520	PRKDC,XRCC5
REACT_13526	NADE modulates death signalling	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	7531,4804	YWHAE,NGFR
REACT_1763	Homologous DNA pairing and strand exchange	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	6118,5893	RPA2,RAD52
REACT_19268	Nectin/Necl  trans heterodimerization	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	81607,5818	PVRL4,PVRL1
REACT_8028	Terminal pathway of complement	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	733,729	C8G,C6
REACT_160111	Ubiquinol biosynthesis	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	10229,57107	COQ7,PDSS2
REACT_963	Apoptotic factor-mediated response	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	54205,317	CYCS,APAF1
REACT_163646	Transfer of SUMO from E1 to E2 (UBE2I, UBC9)	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	6612,7329	SUMO3,UBE2I
5416845	Innate Immune System	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	7323,7322	UBE2D3,UBE2D2
5417776	Negative regulators of RIG-I/MDA5 signaling	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	7323,7322	UBE2D3,UBE2D2
5417215	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.889200771362494	-0.117432229413284	7	2	0.000632311097059753	3163	7167	7323,7322	UBE2D3,UBE2D2
REACT_1258	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.889749860102513	-0.116814911824202	79	30	0.0094846664558963	3163	7167	6202,8663,1975,8664,1964,6235,3646,6229,6232,1973,7458,8666,6203,3921,8667,6189,6191,27335,1981,6234,1968,6205,1978,6208,6223,6206,8662,6188,1977,26986	RPS8,EIF3C,EIF4B,EIF3D,EIF1AX,RPS29,EIF3E,RPS24,RPS27,EIF4A1,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPS4X,EIF3K,EIF4G1,RPS28,EIF2S3,RPS11,EIF4EBP1,RPS14,RPS19,RPS12,EIF3B,RPS3,EIF4E,PABPC1
REACT_121380	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes	0.89063007766128	-0.115826114307656	10	3	0.00094846664558963	3163	7167	762,358,6521	CA4,AQP1,SLC4A1
REACT_121329	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes	0.89063007766128	-0.115826114307656	10	3	0.00094846664558963	3163	7167	762,358,6521	CA4,AQP1,SLC4A1
REACT_163933	Interaction With The Zona Pellucida	0.89063007766128	-0.115826114307656	10	3	0.00094846664558963	3163	7167	2683,57829,7784	B4GALT1,ZP4,ZP3
REACT_120969	O2/CO2 exchange in erythrocytes	0.89063007766128	-0.115826114307656	10	3	0.00094846664558963	3163	7167	762,358,6521	CA4,AQP1,SLC4A1
REACT_1470	mRNA Capping	0.892864162820978	-0.113320822978416	29	10	0.00316155548529877	3163	7167	2967,5438,902,5439,5441,2968,5440,5434,22916,5437	GTF2H3,POLR2I,CCNH,POLR2J,POLR2L,GTF2H4,POLR2K,POLR2E,NCBP2,POLR2H
REACT_9431	Metabolism of porphyrins	0.899919189231599	-0.105450309431835	24	8	0.00252924438823901	3163	7167	7390,210,645,54578,3145,3162,1352,5498	UROS,ALAD,BLVRB,UGT1A6,HMBS,HMOX1,COX10,PPOX
REACT_1884	MRN complex relocalizes to nuclear foci	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	10111	RAD50
REACT_2174	DNA Damage Bypass	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	51455	REV1
REACT_2198	Translesion synthesis by DNA polymerases bypassing lesion on DNA template	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	51455	REV1
REACT_25302	Reactions specific to the complex N-glycan synthesis pathway	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	4122	MAN2A2
REACT_486	Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	10111	RAD50
REACT_1464	Synthesis of Ketone Bodies	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	622	BDH1
REACT_15551	Catecholamine biosynthesis	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	1644	DDC
REACT_75777	The AIM2 inflammasome	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	9447	AIM2
REACT_19328	Proton/oligonucleotide cotransporters	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	121260	SLC15A4
REACT_18338	Activation of AMPA receptors	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	2890	GRIA1
REACT_23910	Reuptake of GABA	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	6538	SLC6A11
REACT_2125	Carnitine synthesis	0.902649247182481	-0.102421231608037	4	1	0.000316155548529877	3163	7167	6470	SHMT1
REACT_6926	Glutathione conjugation	0.903138786030565	-0.101879042988916	32	11	0.00347771103382864	3163	7167	653689,2678,26873,2954,119391,79017,4259,2941,2687,55748,2950	GSTT2B,GGT1,OPLAH,GSTZ1,GSTO2,GGCT,MGST3,GSTA4,GGT5,CNDP2,GSTP1
REACT_163919	Inactivation, recovery and regulation of the phototransduction cascade	0.903138786030565	-0.101879042988916	32	11	0.00347771103382864	3163	7167	4836,8787,3000,5145,2782,2779,388531,5158,5578,2978,6011	NMT1,RGS9,GUCY2D,PDE6A,GNB1,GNAT1,RGS9BP,PDE6B,PRKCA,GUCA1A,GRK1
REACT_22285	Transport of vitamins, nucleosides, and related molecules	0.903138786030565	-0.101879042988916	32	11	0.00347771103382864	3163	7167	28231,6578,28965,222962,55315,9197,10999,9153,353189,28232,9154	SLCO4A1,SLCO2A1,SLC27A6,SLC29A4,SLC29A3,SLC33A1,SLC27A4,SLC28A2,SLCO4C1,SLCO3A1,SLC28A1
REACT_18422	Trafficking of GluR2-containing AMPA receptors	0.903592112714302	-0.101377223162217	16	5	0.00158077774264938	3163	7167	161,2890,5578,160,80852	AP2A2,GRIA1,PRKCA,AP2A1,GRIP2
REACT_1655	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_2089	RNA Polymerase II Promoter Escape	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_6253	RNA Polymerase II HIV Promoter Escape	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_834	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_6332	HIV Transcription Initiation	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_1851	RNA Polymerase II Transcription Initiation	0.908760657767604	-0.0956735222608365	40	14	0.00442617767941827	3163	7167	2967,6881,5438,2961,902,2957,5439,5441,2968,6908,5440,6874,5434,5437	GTF2H3,TAF10,POLR2I,GTF2E2,CCNH,GTF2A1,POLR2J,POLR2L,GTF2H4,TBP,POLR2K,TAF4,POLR2E,POLR2H
REACT_6237	RNA Pol II CTD phosphorylation and interaction with CE	0.909151834873276	-0.0952431636893508	27	9	0.00284539993676889	3163	7167	2967,5438,902,5439,5441,2968,5440,5434,5437	GTF2H3,POLR2I,CCNH,POLR2J,POLR2L,GTF2H4,POLR2K,POLR2E,POLR2H
REACT_975	RNA Pol II CTD phosphorylation and interaction with CE	0.909151834873276	-0.0952431636893508	27	9	0.00284539993676889	3163	7167	2967,5438,902,5439,5441,2968,5440,5434,5437	GTF2H3,POLR2I,CCNH,POLR2J,POLR2L,GTF2H4,POLR2K,POLR2E,POLR2H
REACT_23947	GABA synthesis, release, reuptake and degradation	0.910989170594899	-0.0932242691749426	19	6	0.00189693329117926	3163	7167	6538,10815,80331,6804,3312,5864	SLC6A11,CPLX1,DNAJC5,STX1A,HSPA8,RAB3A
REACT_1979	Translation initiation complex formation	0.913591730108575	-0.0903714921040935	78	29	0.00916851090736642	3163	7167	6202,8663,1975,8664,1964,6235,3646,6229,6232,1973,7458,8666,6203,3921,8667,6189,6191,27335,1981,6234,1968,6205,6208,6223,6206,8662,6188,1977,26986	RPS8,EIF3C,EIF4B,EIF3D,EIF1AX,RPS29,EIF3E,RPS24,RPS27,EIF4A1,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPS4X,EIF3K,EIF4G1,RPS28,EIF2S3,RPS11,RPS14,RPS19,RPS12,EIF3B,RPS3,EIF4E,PABPC1
REACT_931	Ribosomal scanning and start codon recognition	0.913591730108575	-0.0903714921040935	78	29	0.00916851090736642	3163	7167	6202,8663,1975,8664,1964,6235,3646,6229,6232,1973,7458,8666,6203,3921,8667,6189,6191,27335,1981,6234,1968,6205,6208,6223,6206,8662,1983,6188,1977	RPS8,EIF3C,EIF4B,EIF3D,EIF1AX,RPS29,EIF3E,RPS24,RPS27,EIF4A1,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPS4X,EIF3K,EIF4G1,RPS28,EIF2S3,RPS11,RPS14,RPS19,RPS12,EIF3B,EIF5,RPS3,EIF4E
REACT_11052	Metabolism of non-coding RNA	0.922969551731663	-0.0801590333964757	51	18	0.00569079987353778	3163	7167	25929,11097,7175,6632,23225,55746,6628,9688,22916,6635,10419,8021,51808,96764,79902,81929,8086,129401	GEMIN5,NUPL2,TPR,SNRPD1,NUP210,NUP133,SNRPB,NUP93,NCBP2,SNRPE,PRMT5,NUP214,PHAX,TGS1,NUP85,SEH1L,AAAS,NUP35
REACT_11066	snRNP Assembly	0.922969551731663	-0.0801590333964757	51	18	0.00569079987353778	3163	7167	25929,11097,7175,6632,23225,55746,6628,9688,22916,6635,10419,8021,51808,96764,79902,81929,8086,129401	GEMIN5,NUPL2,TPR,SNRPD1,NUP210,NUP133,SNRPB,NUP93,NCBP2,SNRPE,PRMT5,NUP214,PHAX,TGS1,NUP85,SEH1L,AAAS,NUP35
REACT_25387	Ligand-gated ion channel transport	0.924954025088842	-0.0780112453115845	25	8	0.00252924438823901	3163	7167	2554,285242,2743,2566,2570,441509,2741,2567	GABRA1,HTR3E,GLRB,GABRG2,GABRR2,GLRA4,GLRA1,GABRG3
REACT_163722	The phototransduction cascade	0.924958609617494	-0.078006288830326	33	11	0.00347771103382864	3163	7167	4836,8787,3000,5145,2782,2779,388531,5158,5578,2978,6011	NMT1,RGS9,GUCY2D,PDE6A,GNB1,GNAT1,RGS9BP,PDE6B,PRKCA,GUCA1A,GRK1
REACT_150361	TRIF-mediated programmed cell death	0.927327425421333	-0.0754485660484039	11	3	0.00094846664558963	3163	7167	8737,929,8772	RIPK1,CD14,FADD
REACT_11048	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.927327425421333	-0.0754485660484039	11	3	0.00094846664558963	3163	7167	1646,5740,80270	AKR1C2,PTGIS,HSD3B7
REACT_16942	Hormone ligand-binding receptors	0.927327425421333	-0.0754485660484039	11	3	0.00094846664558963	3163	7167	2492,3973,3972	FSHR,LHCGR,LHB
5311371	Degradation of the extracellular matrix	0.928556461855262	-0.0741240902856433	14	4	0.00126462219411951	3163	7167	4318,9507,4313,170690	MMP9,ADAMTS4,MMP2,ADAMTS16
5310601	Extracellular matrix organization	0.928556461855262	-0.0741240902856433	14	4	0.00126462219411951	3163	7167	4318,9507,4313,170690	MMP9,ADAMTS4,MMP2,ADAMTS16
REACT_6903	Binding and entry of HIV virion	0.930647842212253	-0.0718743308218471	8	2	0.000632311097059753	3163	7167	920,1234	CD4,CCR5
5416846	Immune System	0.930647842212253	-0.0718743308218471	8	2	0.000632311097059753	3163	7167	7323,7322	UBE2D3,UBE2D2
REACT_9058	2-LTR circle formation	0.930647842212253	-0.0718743308218471	8	2	0.000632311097059753	3163	7167	3159,7520	HMGA1,XRCC5
REACT_111083	The citric acid (TCA) cycle and respiratory electron transport	0.931984204515392	-0.0704394123850218	136	52	0.0164400885235536	3163	7167	79944,4729,4712,6391,29796,4726,9123,682,521,4697,3418,54205,1327,1345,51079,2109,374291,5164,4695,10476,7385,4715,4731,4728,1537,4700,4720,3945,5160,516,1350,27089,2271,3939,514,4967,1743,51660,23539,6390,2110,25874,728294,440567,126328,9167,1351,9377,498,4713,55066,1340	L2HGDH,NDUFV2,NDUFB6,SDHC,UQCR10,NDUFS6,SLC16A3,BSG,ATP5I,NDUFA4,IDH2,CYCS,COX4I1,COX6C,NDUFA13,ETFB,NDUFS7,PDK2,NDUFA2,ATP5H,UQCRC2,NDUFB9,NDUFV3,NDUFS8,CYC1,NDUFA6,NDUFS2,LDHB,PDHA1,ATP5G1,COX7C,UQCRQ,FH,LDHA,ATP5E,OGDH,DLST,MPC1,SLC16A8,SDHB,ETFDH,MPC2,D2HGDH,UQCRHL,NDUFA11,COX7A2L,COX8A,COX5A,ATP5A1,NDUFB7,PDPR,COX6B1
REACT_6305	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	0.934664455397069	-0.0675676853362227	97	36	0.0113815997470756	3163	7167	4729,4712,6391,29796,4726,1327,54205,4697,521,1345,51079,2109,374291,4695,10476,7385,4728,4715,4731,1537,4700,4720,516,1350,27089,514,6390,2110,440567,9167,126328,1351,9377,498,4713,1340	NDUFV2,NDUFB6,SDHC,UQCR10,NDUFS6,COX4I1,CYCS,NDUFA4,ATP5I,COX6C,NDUFA13,ETFB,NDUFS7,NDUFA2,ATP5H,UQCRC2,NDUFS8,NDUFB9,NDUFV3,CYC1,NDUFA6,NDUFS2,ATP5G1,COX7C,UQCRQ,ATP5E,SDHB,ETFDH,UQCRHL,COX7A2L,NDUFA11,COX8A,COX5A,ATP5A1,NDUFB7,COX6B1
REACT_12623	Generation of second messenger molecules	0.942433139044482	-0.0592903021821876	34	11	0.00347771103382864	3163	7167	5058,3123,3113,27040,5335,920,7454,4690,919,55740,3937	PAK1,HLA-DRB1,HLA-DPA1,LAT,PLCG1,CD4,WAS,NCK1,CD247,ENAH,LCP2
REACT_25216	Regulation of IFNA signaling	0.944364610870265	-0.0572429470795609	26	8	0.00252924438823901	3163	7167	5770,8651,5777,11274,5781,3454,7297,9021	PTPN1,SOCS1,PTPN6,USP18,PTPN11,IFNAR1,TYK2,SOCS3
REACT_7970	Telomere Maintenance	0.944860855967909	-0.0567176046916163	78	28	0.00885235535883655	3163	7167	5983,5558,8370,85236,3978,8349,8970,55651,1736,5424,8290,54386,6118,5111,5426,8607,7015,26277,8337,5981,128312,8338,57804,3017,25913,7013,5425,55135	RFC3,PRIM2,HIST2H4A,HIST1H2BK,LIG1,HIST2H2BE,HIST1H2BJ,NHP2,DKC1,POLD1,HIST3H3,TERF2IP,RPA2,PCNA,POLE,RUVBL1,TERT,TINF2,HIST2H2AA3,RFC1,HIST3H2BB,HIST2H2AC,POLD4,HIST1H2BD,POT1,TERF1,POLD2,WRAP53
REACT_7972	Activation of C3 and C5	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	718	C3
REACT_22310	Organic anion transport	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	9356	SLC22A6
REACT_735	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	3033	HADH
REACT_1178	Disinhibition of SNARE formation	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	5578	PRKCA
REACT_13650	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	3642	INSM1
REACT_1697	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	3033	HADH
REACT_1708	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	3033	HADH
REACT_1861	Ketone body metabolism	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	622	BDH1
REACT_20646	Sodium-coupled sulphate, di- and tri-carboxylate transporters	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	26266	SLC13A4
REACT_15502	CaMK IV-mediated phosphorylation of CREB	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	1385	CREB1
REACT_1915	G2 Phase	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	1871	E2F3
REACT_19165	Na+-dependent glucose transporters	0.945636882423471	-0.0558966288360098	5	1	0.000316155548529877	3163	7167	6523	SLC5A1
REACT_21352	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.946348167576922	-0.055144735804972	145	55	0.0173885551691432	3163	7167	126961,64216,7978,8850,6908,5440,8349,8358,8970,7702,6621,51728,54815,661,284119,9014,2968,9112,8932,653604,3017,10302,57459,2976,2967,902,8370,5441,2648,9328,79101,9219,85236,84265,5451,3021,6618,53615,4784,9015,10919,55718,55290,5434,4782,5437,8337,2972,128312,8338,3020,11178,3066,333932,5442	HIST2H3C,TFB2M,MTERF,KAT2B,TBP,POLR2K,HIST2H2BE,HIST1H3B,HIST1H2BJ,ZNF143,SNAPC4,POLR3K,GATAD2A,POLR3D,PTRF,TAF1B,GTF2H4,MTA1,MBD2,HIST2H3D,HIST1H2BD,SNAPC5,GATAD2B,GTF3C2,GTF2H3,CCNH,HIST2H4A,POLR2L,KAT2A,GTF3C5,TAF1D,MTA2,HIST1H2BK,POLR3GL,POU2F1,H3F3B,SNAPC2,MBD3,NFIX,TAF1A,EHMT2,POLR3E,BRF2,POLR2E,NFIC,POLR2H,HIST2H2AA3,BRF1,HIST3H2BB,HIST2H2AC,H3F3A,LZTS1,HDAC2,HIST2H3A,POLRMT
REACT_13723	Neurotransmitter Release Cycle	0.947331946210497	-0.0541057232337198	37	12	0.00379386658235852	3163	7167	6582,80331,6804,8224,1103,3312,5864,4128,10815,6538,6571,6512	SLC22A2,DNAJC5,STX1A,SYN3,CHAT,HSPA8,RAB3A,MAOA,CPLX1,SLC6A11,SLC18A2,SLC1A7
REACT_6932	Complement cascade	0.948589737047957	-0.0527788846484611	58	20	0.00632311097059753	3163	7167	718,10878,1604,3075,729,725,713,4153,4179,733,712,7448,1378,1675,714,2219,5627,722,10747,2220	C3,CFHR3,CD55,CFH,C6,C4BPB,C1QB,MBL2,CD46,C8G,C1QA,VTN,CR1,CFD,C1QC,FCN1,PROS1,C4BPA,MASP2,FCN2
REACT_13705	Phase 1 - Functionalization of compounds	0.950834755938358	-0.050414989748589	71	25	0.00790388871324692	3163	7167	56603,1591,1588,1565,2326,1589,10858,6916,1592,54905,1585,1584,1583,57834,2327,55902,5740,1548,54498,120227,4128,5742,66002,84532,2328	CYP26B1,CYP24A1,CYP19A1,CYP2D6,FMO1,CYP21A2,CYP46A1,TBXAS1,CYP26A1,CYP2W1,CYP11B2,CYP11B1,CYP11A1,CYP4F11,FMO2,ACSS2,PTGIS,CYP2A6,SMOX,CYP2R1,MAOA,PTGS1,CYP4F12,ACSS1,FMO3
REACT_11053	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.951383198216769	-0.0498383552021537	15	4	0.00126462219411951	3163	7167	1646,5740,10858,80270	AKR1C2,PTGIS,CYP46A1,HSD3B7
REACT_6266	Early Phase of HIV Life Cycle	0.952293680258202	-0.0488818040971294	18	5	0.00158077774264938	3163	7167	3978,920,3159,1234,7520	LIG1,CD4,HMGA1,CCR5,XRCC5
REACT_13425	Miscellaneous substrates	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	1565,57834,54905	CYP2D6,CYP4F11,CYP2W1
REACT_24987	GABA A receptor activation	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	2554,2566,2567	GABRA1,GABRG2,GABRG3
REACT_121313	Keratan sulfate degradation	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	2331,5549,176	FMOD,PRELP,ACAN
REACT_150260	Condensation of Prometaphase Chromosomes	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	10592,891,983	SMC2,CCNB1,CDK1
REACT_12528	Regulation of pyruvate dehydrogenase (PDH) complex	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	5160,5164,55066	PDHA1,PDK2,PDPR
REACT_11042	Recycling of bile acids and salts	0.952373519127763	-0.0487979691157389	12	3	0.00094846664558963	3163	7167	8714,2172,345274	ABCC3,FABP6,SLC10A6
REACT_24938	TRAF6 mediated IRF7 activation	0.952515392844219	-0.048649011645488	32	10	0.00316155548529877	3163	7167	7189,29110,9641,7706,7186,10010,3665,57506,3661,3659	TRAF6,TBK1,IKBKE,TRIM25,TRAF2,TANK,IRF7,MAVS,IRF3,IRF1
REACT_1785	Citric acid cycle (TCA cycle)	0.954189672776093	-0.0468928088720359	21	6	0.00189693329117926	3163	7167	6390,3418,4967,1743,6391,2271	SDHB,IDH2,OGDH,DLST,SDHC,FH
REACT_24019	Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)	0.954189672776093	-0.0468928088720359	21	6	0.00189693329117926	3163	7167	23478,3952,51764,1499,6934,346562	SEC11A,LEP,GNG13,CTNNB1,TCF7L2,GNAT3
REACT_23974	Incretin Synthesis, Secretion, and Inactivation	0.956580733141191	-0.0443900889159932	24	7	0.00221308883970914	3163	7167	23478,3952,51764,1499,2626,6934,346562	SEC11A,LEP,GNG13,CTNNB1,GATA4,TCF7L2,GNAT3
REACT_19320	Sodium/Calcium exchangers	0.957100920538402	-0.0438464379811342	9	2	0.000632311097059753	3163	7167	283652,80024	SLC24A5,SLC8B1
REACT_21314	Relaxin receptors	0.957100920538402	-0.0438464379811342	9	2	0.000632311097059753	3163	7167	59350,339403	RXFP1,RXFP4
REACT_9472	Digestion of dietary carbohydrate	0.957100920538402	-0.0438464379811342	9	2	0.000632311097059753	3163	7167	11181,6476	TREH,SI
REACT_169168	Senescence-Associated Secretory Phenotype (SASP)	0.957485742149968	-0.0434444487431984	112	41	0.0129623774897249	3163	7167	126961,51433,6195,8349,8358,8970,1026,3490,3725,64682,6196,4790,51343,10393,653604,51434,1032,6774,3017,7311,8370,1019,79813,85236,3021,8697,2353,7316,7324,1051,8881,10919,996,3576,8337,3020,8338,128312,11065,333932,29945	HIST2H3C,ANAPC5,RPS6KA1,HIST2H2BE,HIST1H3B,HIST1H2BJ,CDKN1A,IGFBP7,JUN,ANAPC1,RPS6KA2,NFKB1,FZR1,ANAPC10,HIST2H3D,ANAPC7,CDKN2D,STAT3,HIST1H2BD,UBA52,HIST2H4A,CDK4,EHMT1,HIST1H2BK,H3F3B,CDC23,FOS,UBC,UBE2E1,CEBPB,CDC16,EHMT2,CDC27,IL8,HIST2H2AA3,H3F3A,HIST2H2AC,HIST3H2BB,UBE2C,HIST2H3A,ANAPC4
REACT_172623	Chromatin organization	0.96224399730505	-0.0384872250242291	140	52	0.0164400885235536	3163	7167	126961,57634,8850,8349,8358,10629,8970,9643,11091,317772,440689,55257,10902,27154,284058,23587,653604,27097,54934,117143,1386,3017,6871,92815,84148,3054,8336,6881,10445,26009,55167,8370,2648,11143,56943,85236,54556,26610,23326,23338,79960,54859,55250,8607,84289,23522,60,8337,128312,8338,86,333932	HIST2H3C,EP400,KAT2B,HIST2H2BE,HIST1H3B,TAF6L,HIST1H2BJ,MORF4L2,WDR5,HIST2H2AB,HIST2H2BF,MRGBP,BRD8,BRPF3,KANSL1,ELP5,HIST2H3D,TAF5L,KANSL2,TADA1,ATF2,HIST1H2BD,TADA2A,HIST3H2A,KAT8,HCFC1,HIST1H2AM,TAF10,MCRS1,ZZZ3,MSL2,HIST2H4A,KAT2A,KAT7,ENY2,HIST1H2BK,ING3,ELP4,USP22,JADE2,JADE1,ELP6,ELP2,RUVBL1,ING5,KAT6B,ACTB,HIST2H2AA3,HIST3H2BB,HIST2H2AC,ACTL6A,HIST2H3A
REACT_172610	HATs acetylate histones	0.96224399730505	-0.0384872250242291	140	52	0.0164400885235536	3163	7167	126961,57634,8850,8349,8358,10629,8970,9643,11091,317772,440689,55257,10902,27154,284058,23587,653604,27097,54934,117143,1386,3017,6871,92815,84148,3054,8336,6881,10445,26009,55167,8370,2648,11143,56943,85236,54556,26610,23326,23338,79960,54859,55250,8607,84289,23522,60,8337,128312,8338,86,333932	HIST2H3C,EP400,KAT2B,HIST2H2BE,HIST1H3B,TAF6L,HIST1H2BJ,MORF4L2,WDR5,HIST2H2AB,HIST2H2BF,MRGBP,BRD8,BRPF3,KANSL1,ELP5,HIST2H3D,TAF5L,KANSL2,TADA1,ATF2,HIST1H2BD,TADA2A,HIST3H2A,KAT8,HCFC1,HIST1H2AM,TAF10,MCRS1,ZZZ3,MSL2,HIST2H4A,KAT2A,KAT7,ENY2,HIST1H2BK,ING3,ELP4,USP22,JADE2,JADE1,ELP6,ELP2,RUVBL1,ING5,KAT6B,ACTB,HIST2H2AA3,HIST3H2BB,HIST2H2AC,ACTL6A,HIST2H3A
REACT_172633	Chromatin modifying enzymes	0.96224399730505	-0.0384872250242291	140	52	0.0164400885235536	3163	7167	126961,57634,8850,8349,8358,10629,8970,9643,11091,317772,440689,55257,10902,27154,284058,23587,653604,27097,54934,117143,1386,3017,6871,92815,84148,3054,8336,6881,10445,26009,55167,8370,2648,11143,56943,85236,54556,26610,23326,23338,79960,54859,55250,8607,84289,23522,60,8337,128312,8338,86,333932	HIST2H3C,EP400,KAT2B,HIST2H2BE,HIST1H3B,TAF6L,HIST1H2BJ,MORF4L2,WDR5,HIST2H2AB,HIST2H2BF,MRGBP,BRD8,BRPF3,KANSL1,ELP5,HIST2H3D,TAF5L,KANSL2,TADA1,ATF2,HIST1H2BD,TADA2A,HIST3H2A,KAT8,HCFC1,HIST1H2AM,TAF10,MCRS1,ZZZ3,MSL2,HIST2H4A,KAT2A,KAT7,ENY2,HIST1H2BK,ING3,ELP4,USP22,JADE2,JADE1,ELP6,ELP2,RUVBL1,ING5,KAT6B,ACTB,HIST2H2AA3,HIST3H2BB,HIST2H2AC,ACTL6A,HIST2H3A
REACT_19231	G alpha (i) signalling events	0.964382266198125	-0.0362675212741723	238	92	0.0290863104647487	3163	7167	5999,4544,2840,8601,2782,338442,2783,351,23566,3352,431704,6002,56923,57121,2781,27199,109,6754,85397,846,113,718,152,283869,256933,56477,53637,10287,2788,107,1132,548645,56670,2916,1233,114,59345,728458,8786,3576,5540,6001,346562,2779,10636,9170,11255,57007,4887,1236,2832,6000,5996,1815,134,2793,23596,112,11251,51764,5539,2587,623,2771,4543,2912,339403,150,6755,3354,6364,9568,1903,2786,10316,8698,2913,8787,64407,2652,183,9290,2917,111,259287,2914,4987,2852,165140,1234,6370,2847	RGS4,MTNR1B,GPR17,RGS20,GNB1,HCAR2,GNB2,APP,LPAR3,HTR1D,RGS21,RGS12,NMUR2,LPAR5,GNAZ,OXGR1,ADCY3,SSTR4,RGS8,CASR,ADCY7,C3,ADRA2C,NPW,NPB,CCL28,S1PR5,RGS19,GNG7,ADCY1,CHRM4,DNAJC25,SUCNR1,GRM6,CCR4,ADCY8,GNB4,OPN1MW2,RGS11,IL8,NPY4R,RGS10,GNAT3,GNAT1,RGS14,LPAR2,HRH3,ACKR3,NPY2R,CCR7,NPBWR2,RGS7,RGS1,DRD4,ADORA1,GNGT2,OPN3,ADCY6,PTGDR2,GNG13,PPY,GALR1,BDKRB1,GNAI2,MTNR1A,GRM2,RXFP4,ADRA2A,SSTR5,HTR1E,CCL20,GABBR2,S1PR3,GNG4,NMUR1,S1PR4,GRM3,RGS9,RGS18,OPN1MW,AGT,GPR55,GRM7,ADCY5,TAS2R41,GRM4,OPRL1,GPER1,OXER1,CCR5,CCL25,MCHR1
REACT_22172	Chromosome Maintenance	0.967160996075686	-0.0333903071327366	126	46	0.0145431552323743	3163	7167	23353,55355,3978,8349,4869,8970,55651,7329,5424,8290,55320,4000,54386,6118,5111,4001,26277,545,57804,3017,3306,25777,5983,1058,10274,8370,5558,23224,85236,672,1736,79682,8607,5426,7015,8243,8337,5981,8338,8467,128312,25913,7013,5425,55135,5885	SUN1,HJURP,LIG1,HIST2H2BE,NPM1,HIST1H2BJ,NHP2,UBE2I,POLD1,HIST3H3,MIS18BP1,LMNA,TERF2IP,RPA2,PCNA,LMNB1,TINF2,ATR,POLD4,HIST1H2BD,HSPA2,SUN2,RFC3,CENPA,STAG1,HIST2H4A,PRIM2,SYNE2,HIST1H2BK,BRCA1,DKC1,CENPU,RUVBL1,POLE,TERT,SMC1A,HIST2H2AA3,RFC1,HIST2H2AC,SMARCA5,HIST3H2BB,POT1,TERF1,POLD2,WRAP53,RAD21
REACT_12591	Glutamate Neurotransmitter Release Cycle	0.967313560053577	-0.033232575434768	16	4	0.00126462219411951	3163	7167	10815,6804,6512,5864	CPLX1,STX1A,SLC1A7,RAB3A
REACT_160078	Peptide hormone metabolism	0.968690279914298	-0.0318103467548862	86	30	0.0094846664558963	3163	7167	64924,1636,2626,3800,23265,2688,3630,6934,290,23478,1499,183,6804,3625,56605,5972,9314,3972,149371,346562,3952,55770,51764,723961,1509,1363,43,4311,10159,2999	SLC30A5,ACE,GATA4,KIF5C,EXOC7,GH1,INS,TCF7L2,ANPEP,SEC11A,CTNNB1,AGT,STX1A,INHBB,ERO1LB,REN,KLF4,LHB,EXOC8,GNAT3,LEP,EXOC2,GNG13,INS-IGF2,CTSD,CPE,ACHE,MME,ATP6AP2,GZMH
REACT_22297	Heme degradation	0.969154926969796	-0.0313307965175895	13	3	0.00094846664558963	3163	7167	54578,3162,645	UGT1A6,HMOX1,BLVRB
REACT_567	Assembly of the ORC complex at the origin of replication	0.969645614768458	-0.0308246198391998	6	1	0.000316155548529877	3163	7167	4999	ORC2
REACT_163812	Conjugation of SUMO to E1 (UBA2:SAE1)	0.969645614768458	-0.0308246198391998	6	1	0.000316155548529877	3163	7167	6612	SUMO3
REACT_160	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.969645614768458	-0.0308246198391998	6	1	0.000316155548529877	3163	7167	1666	DECR1
REACT_13567	Cytochrome P450 - arranged by substrate type	0.973598059406307	-0.0267567305253637	53	17	0.0053746443250079	3163	7167	56603,1591,1588,1565,1589,10858,6916,1592,1585,54905,1584,57834,1583,5740,1548,120227,66002	CYP26B1,CYP24A1,CYP19A1,CYP2D6,CYP21A2,CYP46A1,TBXAS1,CYP26A1,CYP11B2,CYP2W1,CYP11B1,CYP4F11,CYP11A1,PTGIS,CYP2A6,CYP2R1,CYP4F12
REACT_111059	Regulation of Signaling by NODAL	0.973718631256617	-0.0266328966866842	10	2	0.000632311097059753	3163	7167	7044,10637	LEFTY2,LEFTY1
REACT_34	Ethanol oxidation	0.973718631256617	-0.0266328966866842	10	2	0.000632311097059753	3163	7167	55902,84532	ACSS2,ACSS1
REACT_18290	Calcitonin-like ligand receptors	0.973718631256617	-0.0266328966866842	10	2	0.000632311097059753	3163	7167	10268,10267	RAMP3,RAMP1
REACT_169185	DNA Damage/Telomere Stress Induced Senescence	0.97594778718821	-0.0243461907334372	77	26	0.00822004426177679	3163	7167	9134,8091,57634,8370,29855,85236,8349,8970,1026,8290,898,54386,4001,3005,10111,26277,472,8337,23523,3159,128312,8338,3017,25913,7013,3006	CCNE2,HMGA2,EP400,HIST2H4A,UBN1,HIST1H2BK,HIST2H2BE,HIST1H2BJ,CDKN1A,HIST3H3,CCNE1,TERF2IP,LMNB1,H1F0,RAD50,TINF2,ATM,HIST2H2AA3,CABIN1,HMGA1,HIST3H2BB,HIST2H2AC,HIST1H2BD,POT1,TERF1,HIST1H1C
REACT_1008	Glycogen breakdown (glycogenolysis)	0.978258818614312	-0.0219810032485655	17	4	0.00126462219411951	3163	7167	5236,5261,5257,5834	PGM1,PHKG2,PHKB,PYGB
REACT_163834	FCERI mediated Ca+2 mobilization	0.98160034058811	-0.0185710386130936	49	15	0.00474233322794815	3163	7167	7409,10451,27040,5335,4775,6464,5336,3708,7410,4773,3937,3710,4772,4067,6850	VAV1,VAV3,LAT,PLCG1,NFATC3,SHC1,PLCG2,ITPR1,VAV2,NFATC2,LCP2,ITPR3,NFATC1,LYN,SYK
REACT_19188	Inositol transporters	0.983053088661579	-0.0170921535164995	7	1	0.000316155548529877	3163	7167	6523	SLC5A1
REACT_75792	Meiotic Synapsis	0.983150922647659	-0.0169926379162897	76	25	0.00790388871324692	3163	7167	23353,25777,8370,10274,23224,85236,8349,8970,672,7329,8290,4000,54386,4001,26277,8243,545,8337,8338,128312,3017,3306,25913,7013,5885	SUN1,SUN2,HIST2H4A,STAG1,SYNE2,HIST1H2BK,HIST2H2BE,HIST1H2BJ,BRCA1,UBE2I,HIST3H3,LMNA,TERF2IP,LMNB1,TINF2,SMC1A,ATR,HIST2H2AA3,HIST2H2AC,HIST3H2BB,HIST1H2BD,HSPA2,POT1,TERF1,RAD21
REACT_20619	mRNA Decay by 3' to 5' Exoribonuclease	0.984027788109922	-0.0161011423795153	11	2	0.000632311097059753	3163	7167	54512,56915	EXOSC4,EXOSC5
REACT_13797	CYP2E1 reactions	0.984027788109922	-0.0161011423795153	11	2	0.000632311097059753	3163	7167	1565,1548	CYP2D6,CYP2A6
REACT_1079	Formation of the ternary complex, and subsequently, the 43S complex	0.98414133003173	-0.0159857641623825	71	23	0.00727157761618716	3163	7167	6202,8663,8664,1964,6235,3646,6229,6232,8666,6203,3921,8667,6189,6191,27335,6234,1968,6205,6208,6223,6206,6188,8662	RPS8,EIF3C,EIF3D,EIF1AX,RPS29,EIF3E,RPS24,RPS27,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPS4X,EIF3K,RPS28,EIF2S3,RPS11,RPS14,RPS19,RPS12,RPS3,EIF3B
REACT_19324	PD-1 signaling	0.984464331068805	-0.0156576120633042	27	7	0.00221308883970914	3163	7167	3123,3113,5133,920,5777,919,5781	HLA-DRB1,HLA-DPA1,PDCD1,CD4,PTPN6,CD247,PTPN11
REACT_13814	Fatty acids	0.987438245001918	-0.01264132086928	15	3	0.00094846664558963	3163	7167	1565,57834,66002	CYP2D6,CYP4F11,CYP4F12
REACT_160274	FCGR activation	0.989466651886985	-0.0105892164912864	34	9	0.00284539993676889	3163	7167	2268,2534,2209,919,2212,4067,6850,6714,2214	FGR,FYN,FCGR1A,CD247,FCGR2A,LYN,SYK,SRC,FCGR3A
REACT_15398	Glycoprotein hormones	0.990358641924152	-0.00968813688561732	12	2	0.000632311097059753	3163	7167	3625,3972	INHBB,LHB
REACT_21264	Formyl peptide receptors bind formyl peptides and many other ligands	0.990539552437575	-0.00950548185120796	8	1	0.000316155548529877	3163	7167	351	APP
REACT_172744	Condensation of Prophase Chromosomes	0.992372109639696	-0.00765713150974113	74	23	0.00727157761618716	3163	7167	126961,8370,23133,85236,8349,3021,8358,8970,10592,891,8290,983,387893,6418,653604,8337,3020,8338,128312,54892,79648,3017,333932	HIST2H3C,HIST2H4A,PHF8,HIST1H2BK,HIST2H2BE,H3F3B,HIST1H3B,HIST1H2BJ,SMC2,CCNB1,HIST3H3,CDK1,SETD8,SET,HIST2H3D,HIST2H2AA3,H3F3A,HIST2H2AC,HIST3H2BB,NCAPG2,MCPH1,HIST1H2BD,HIST2H3A
REACT_163994	FCERI mediated NF-kB activation	0.993172656960954	-0.00685075597179922	44	12	0.00379386658235852	3163	7167	5170,7189,8517,23118,387522,4792,4790,3551,10892,646626,6885,4067	PDPK1,TRAF6,IKBKG,TAB2,TMEM189-UBE2V1,NFKBIA,NFKB1,IKBKB,MALT1,LOC646626,MAP3K7,LYN
REACT_12582	Phosphorylation of CD3 and TCR zeta chains	0.99319010102976	-0.00683319214189327	23	5	0.00158077774264938	3163	7167	5788,3123,3113,920,919	PTPRC,HLA-DRB1,HLA-DPA1,CD4,CD247
REACT_115846	Defensins	0.993791204389935	-0.00622815033614269	50	14	0.00442617767941827	3163	7167	245929,728358,1667,920,1670,417,644414,245915,414325,613211,613210,503618,5645,55894	DEFB115,DEFA1B,DEFA1,CD4,DEFA5,ART1,DEFB131,DEFB112,DEFB103A,DEFB134,DEFB136,DEFB104B,PRSS2,DEFB103B
REACT_6784	Glucuronidation	0.993938642196892	-0.00607980240296626	20	4	0.00126462219411951	3163	7167	54578,7363,7360,7358	UGT1A6,UGT2B4,UGP2,UGDH
REACT_6918	Integration of provirus	0.994213862816685	-0.00580294172868938	13	2	0.000632311097059753	3163	7167	3159,7520	HMGA1,XRCC5
REACT_11040	Bile acid and bile salt metabolism	0.994733622732382	-0.00528029351268095	33	8	0.00252924438823901	3163	7167	1646,5740,10858,2172,345274,8714,3295,80270	AKR1C2,PTGIS,CYP46A1,FABP6,SLC10A6,ABCC3,HSD17B4,HSD3B7
REACT_11054	Synthesis of bile acids and bile salts	0.995500926649821	-0.00450922463972443	24	5	0.00158077774264938	3163	7167	3295,1646,5740,10858,80270	HSD17B4,AKR1C2,PTGIS,CYP46A1,HSD3B7
REACT_6959	Phase II conjugation	0.995975880082825	-0.00403223847508173	90	28	0.00885235535883655	3163	7167	2678,26873,2954,4837,7363,7360,4259,7358,25830,10861,2687,2950,4548,6818,653689,27430,79017,119391,9061,54578,191,1312,2941,1836,10380,445329,55748,6820	GGT1,OPLAH,GSTZ1,NNMT,UGT2B4,UGP2,MGST3,UGDH,SULT4A1,SLC26A1,GGT5,GSTP1,MTR,SULT1A3,GSTT2B,MAT2B,GGCT,GSTO2,PAPSS1,UGT1A6,AHCY,COMT,GSTA4,SLC26A2,BPNT1,SULT1A4,CNDP2,SULT2B1
REACT_1309	RNA Polymerase I Transcription	0.996005774850498	-0.00400222337167836	106	34	0.0107492886500158	3163	7167	126961,57459,2967,902,2648,8370,8850,6908,79101,5440,9219,85236,8349,3021,8358,8970,53615,54815,9015,284119,9014,10919,2968,9112,8932,653604,5437,8337,128312,8338,3020,3017,3066,333932	HIST2H3C,GATAD2B,GTF2H3,CCNH,KAT2A,HIST2H4A,KAT2B,TBP,TAF1D,POLR2K,MTA2,HIST1H2BK,HIST2H2BE,H3F3B,HIST1H3B,HIST1H2BJ,MBD3,GATAD2A,TAF1A,PTRF,TAF1B,EHMT2,GTF2H4,MTA1,MBD2,HIST2H3D,POLR2H,HIST2H2AA3,HIST3H2BB,HIST2H2AC,H3F3A,HIST1H2BD,HDAC2,HIST2H3A
REACT_12596	Translocation of ZAP-70 to Immunological synapse	0.996100150925273	-0.00390747331484216	21	4	0.00126462219411951	3163	7167	3123,3113,920,919	HLA-DRB1,HLA-DPA1,CD4,CD247
REACT_11041	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.996100150925273	-0.00390747331484216	21	4	0.00126462219411951	3163	7167	3295,1646,5740,80270	HSD17B4,AKR1C2,PTGIS,HSD3B7
REACT_18319	Class C/3 (Metabotropic glutamate/pheromone receptors)	0.996295187137779	-0.00371169267893861	40	10	0.00316155548529877	3163	7167	2916,9568,2917,259287,83756,2914,2913,846,80834,2912	GRM6,GABBR2,GRM7,TAS2R41,TAS1R3,GRM4,GRM3,CASR,TAS1R2,GRM2
REACT_23824	Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.996544967348572	-0.00346101506032597	14	2	0.000632311097059753	3163	7167	23478,2626	SEC11A,GATA4
REACT_15452	Peptide hormone biosynthesis	0.996544967348572	-0.00346101506032597	14	2	0.000632311097059753	3163	7167	3625,3972	INHBB,LHB
REACT_1974	RNA Polymerase I Promoter Clearance	0.996563289915778	-0.00344262913759465	104	33	0.0104331331014859	3163	7167	126961,57459,2967,902,2648,8370,8850,6908,79101,5440,9219,85236,8349,3021,8358,8970,53615,54815,9015,9014,10919,2968,9112,8932,653604,5437,8337,128312,8338,3020,3017,3066,333932	HIST2H3C,GATAD2B,GTF2H3,CCNH,KAT2A,HIST2H4A,KAT2B,TBP,TAF1D,POLR2K,MTA2,HIST1H2BK,HIST2H2BE,H3F3B,HIST1H3B,HIST1H2BJ,MBD3,GATAD2A,TAF1A,TAF1B,EHMT2,GTF2H4,MTA1,MBD2,HIST2H3D,POLR2H,HIST2H2AA3,HIST3H2BB,HIST2H2AC,H3F3A,HIST1H2BD,HDAC2,HIST2H3A
REACT_9406	APOBEC3G mediated resistance to HIV-1 infection	0.997052798110477	-0.00295155344104887	10	1	0.000316155548529877	3163	7167	3159	HMGA1
REACT_111183	Meiosis	0.997122428246031	-0.00288171992324961	118	38	0.0120139108441353	3163	7167	23353,126961,8349,8358,8970,641,7329,8290,4000,54386,6118,4001,26277,653604,545,3017,3306,25777,10274,8370,1019,23224,85236,56979,4439,3021,672,10111,8243,472,8337,3020,8338,128312,25913,7013,333932,5885	SUN1,HIST2H3C,HIST2H2BE,HIST1H3B,HIST1H2BJ,BLM,UBE2I,HIST3H3,LMNA,TERF2IP,RPA2,LMNB1,TINF2,HIST2H3D,ATR,HIST1H2BD,HSPA2,SUN2,STAG1,HIST2H4A,CDK4,SYNE2,HIST1H2BK,PRDM9,MSH5,H3F3B,BRCA1,RAD50,SMC1A,ATM,HIST2H2AA3,H3F3A,HIST2H2AC,HIST3H2BB,POT1,TERF1,HIST2H3A,RAD21
REACT_7963	Packaging Of Telomere Ends	0.997489293683807	-0.00251386342478445	50	13	0.0041100221308884	3163	7167	54386,8370,26277,85236,8349,8337,8970,128312,8338,8290,3017,25913,7013	TERF2IP,HIST2H4A,TINF2,HIST1H2BK,HIST2H2BE,HIST2H2AA3,HIST1H2BJ,HIST3H2BB,HIST2H2AC,HIST3H3,HIST1H2BD,POT1,TERF1
REACT_13433	Biological oxidations	0.998418579953404	-0.00158267181116216	160	53	0.0167562440720835	3163	7167	1591,2678,1588,4837,7363,7360,1589,10858,7358,10861,2687,2950,1592,54905,1585,27430,57834,55902,54498,9061,54578,191,5742,2941,1312,1836,6820,2328,56603,2954,26873,1565,2326,4259,25830,6916,4548,6818,653689,119391,1584,79017,1583,2327,5740,1548,120227,4128,10380,445329,55748,66002,84532	CYP24A1,GGT1,CYP19A1,NNMT,UGT2B4,UGP2,CYP21A2,CYP46A1,UGDH,SLC26A1,GGT5,GSTP1,CYP26A1,CYP2W1,CYP11B2,MAT2B,CYP4F11,ACSS2,SMOX,PAPSS1,UGT1A6,AHCY,PTGS1,GSTA4,COMT,SLC26A2,SULT2B1,FMO3,CYP26B1,GSTZ1,OPLAH,CYP2D6,FMO1,MGST3,SULT4A1,TBXAS1,MTR,SULT1A3,GSTT2B,GSTO2,CYP11B1,GGCT,CYP11A1,FMO2,PTGIS,CYP2A6,CYP2R1,MAOA,BPNT1,SULT1A4,CNDP2,CYP4F12,ACSS1
REACT_169436	Oxidative Stress Induced Senescence	0.998769076997643	-0.00123168121033666	127	40	0.0126462219411951	3163	7167	126961,57690,50488,8349,8358,8970,1432,5606,3725,57332,5601,653604,6045,5600,1032,3017,23135,7311,8370,5609,7867,1019,1871,85236,23466,8550,22955,3021,2353,7316,9261,7027,8337,4217,3020,8338,128312,1870,333932,27327	HIST2H3C,TNRC6C,MINK1,HIST2H2BE,HIST1H3B,HIST1H2BJ,MAPK14,MAP2K3,JUN,CBX8,MAPK9,HIST2H3D,RNF2,MAPK11,CDKN2D,HIST1H2BD,KDM6B,UBA52,HIST2H4A,MAP2K7,MAPKAPK3,CDK4,E2F3,HIST1H2BK,CBX6,MAPKAPK5,SCMH1,H3F3B,FOS,UBC,MAPKAPK2,TFDP1,HIST2H2AA3,MAP3K5,H3F3A,HIST2H2AC,HIST3H2BB,E2F2,HIST2H3A,TNRC6A
REACT_8024	Initial triggering of complement	0.99876926276056	-0.00123149521849578	40	9	0.00284539993676889	3163	7167	713,718,4153,712,714,1675,2219,2220,10747	C1QB,C3,MBL2,C1QA,C1QC,CFD,FCN1,FCN2,MASP2
REACT_160300	Binding and Uptake of Ligands by Scavenger Receptors	0.998792581754478	-0.00120814776221192	61	16	0.00505848877647803	3163	7167	10808,55576,1284,1277,23166,948,78989,8578,811,8685,259,6678,117156,3320,949,286133	HSPH1,STAB2,COL4A2,COL1A1,STAB1,CD36,COLEC11,SCARF1,CALR,MARCO,AMBP,SPARC,SCGB3A2,HSP90AA1,SCARB1,SCARA5
REACT_13543	Xenobiotics	0.998827345646636	-0.00117334245046626	20	3	0.00094846664558963	3163	7167	1565,1548,54905	CYP2D6,CYP2A6,CYP2W1
REACT_8012	Creation of C4 and C2 activators	0.998926522462925	-0.00107405412676107	34	7	0.00221308883970914	3163	7167	713,4153,2219,712,714,10747,2220	C1QB,MBL2,FCN1,C1QA,C1QC,MASP2,FCN2
REACT_14828	Class A/1 (Rhodopsin-like receptors)	0.999181868945311	-0.000818465906547696	316	113	0.0357255769838761	3163	7167	5724,29933,4544,2840,552,6375,4923,57105,5732,338442,9002,6361,1241,351,2532,23566,3352,3814,56923,57121,4157,27199,8620,3362,6754,8111,148,718,152,2147,283869,56477,256933,53637,1132,3973,3363,56670,1907,1233,59350,728458,3576,5540,3972,151306,5032,9170,1908,11255,3358,1236,57007,4887,1128,2832,7200,5028,51052,136,23620,2492,64106,1815,3274,147,1816,134,6846,6351,23596,11251,5539,2587,623,4543,1131,5029,84432,150,10381,339403,6755,3354,6364,347148,5739,1906,1903,10316,8698,154,3360,553,2652,6865,183,9290,10161,2863,4987,2852,594857,7201,165140,94233,1234,3269,6370,6870,2847,5731,1812	PTAFR,GPR132,MTNR1B,GPR17,AVPR1A,XCL1,NTSR1,CYSLTR2,PTGER2,HCAR2,F2RL3,CCL17,LTB4R,APP,DARC,LPAR3,HTR1D,KISS1,NMUR2,LPAR5,MC1R,OXGR1,NPFF,HTR6,SSTR4,GPR68,ADRA1A,C3,ADRA2C,F2,NPW,CCL28,NPB,S1PR5,CHRM4,LHCGR,HTR7,SUCNR1,EDN2,CCR4,RXFP1,OPN1MW2,IL8,NPY4R,LHB,GPBAR1,P2RY11,LPAR2,EDN3,HRH3,HTR2C,CCR7,ACKR3,NPY2R,CHRM1,NPBWR2,TRH,P2RY1,PRLH,ADORA2B,NTSR2,FSHR,NPFFR1,DRD4,HRH2,ADRA1B,DRD5,ADORA1,XCL2,CCL4,OPN3,PTGDR2,PPY,GALR1,BDKRB1,MTNR1A,CHRM3,P2RY2,PROK1,ADRA2A,TUBB3,RXFP4,SSTR5,HTR1E,CCL20,QRFP,PTGIR,EDN1,S1PR3,NMUR1,S1PR4,ADRB2,HTR4,AVPR1B,OPN1MW,TACR2,AGT,GPR55,LPAR6,GPR39,OPRL1,GPER1,NPS,TRHR,OXER1,OPN4,CCR5,HRH1,CCL25,TACR3,MCHR1,PTGER1,DRD1
REACT_2204	RNA Polymerase I Chain Elongation	0.999341615159991	-0.000658601670484452	83	23	0.00727157761618716	3163	7167	126961,2967,902,8370,6908,79101,5440,85236,8349,8358,3021,8970,9015,9014,2968,653604,5437,8337,3020,8338,128312,3017,333932	HIST2H3C,GTF2H3,CCNH,HIST2H4A,TBP,TAF1D,POLR2K,HIST1H2BK,HIST2H2BE,HIST1H3B,H3F3B,HIST1H2BJ,TAF1A,TAF1B,GTF2H4,HIST2H3D,POLR2H,HIST2H2AA3,H3F3A,HIST2H2AC,HIST3H2BB,HIST1H2BD,HIST2H3A
REACT_111102	Signal Transduction	0.99945302926942	-0.000547120373639266	1850	757	0.239329750237117	3163	7167	23092,4544,5684,7249,9542,6361,23566,29904,6497,1020,6002,3362,1785,10411,5499,846,7074,23779,64223,391192,7311,343169,8386,403244,5577,79334,29,5228,5335,4087,1233,8312,3972,2932,527,7029,90627,4208,5032,401427,4836,5689,8850,57007,389,7204,343172,7200,7082,23620,1293,3725,9414,10019,65012,5880,1816,8878,2324,23533,80326,51306,6351,57522,2587,1131,29967,2889,7867,58513,1903,5685,2767,388,441911,6865,10603,10254,5986,1025,160,3708,259287,976,7450,441932,940,391,685,5607,26052,3955,6375,6344,8601,324,338442,10402,5566,351,595,56923,10213,388531,55615,113,9550,89839,8321,152,1292,2931,1894,1871,107,8928,81399,7481,4099,2260,5515,5529,7514,284532,5590,10272,6500,6198,10636,119749,6011,7804,6300,57690,8325,284383,6385,5028,51052,136,10267,9491,3274,57449,1395,50999,3654,727758,23263,11108,117145,9138,392,5600,11059,2242,7484,5170,51421,2254,3354,1975,80728,5295,26696,5710,54492,3360,8471,7316,57761,9290,10000,81029,2863,6776,10197,7201,8945,375790,92335,51701,50848,1026,10013,6382,525,161,403239,10268,6196,5136,84986,401993,28514,1499,53358,5145,5216,5296,5701,109,6754,1977,718,2147,1604,391194,51107,9978,7476,4914,7422,4772,983,6009,9630,5898,1981,1208,59345,5540,5533,144124,1855,64857,8650,9958,5563,4887,4092,2832,1111,83933,7059,5870,9249,79541,650,390199,10846,127068,112,9794,51606,89780,5330,81472,5686,8788,2264,256144,7483,7090,391189,27006,8841,10316,84033,55437,3845,5151,6932,8698,23513,6934,5704,9261,2652,26508,1840,10161,4915,5999,1284,343406,5745,4923,1606,5137,2064,8527,4067,5364,55737,283694,7409,5154,533,5687,182,2781,3551,89846,127062,57381,2817,1856,815,256933,207,142,2249,26682,5727,11214,3973,57216,548645,6487,9148,2246,4088,1907,10718,7475,59350,5933,5709,9162,2321,393,4089,56288,4318,1299,9170,1236,22986,27161,2774,6017,1128,79109,3714,64106,1452,1815,8828,8323,5770,8724,3726,81061,11251,3320,64388,6850,150,10381,5046,7091,3280,5692,127623,144165,23365,8038,9564,89941,2917,8817,127124,4987,594857,3516,401994,57636,94233,50649,2847,57530,3339,5565,343563,3949,10395,2782,4090,7531,5578,5143,26683,5881,23002,391196,57521,6484,27199,10193,2642,5290,1849,2740,23526,2788,60485,53632,7478,56670,25805,904,114,5714,728458,8786,391114,402317,83756,4254,5054,8829,151306,3066,2245,10750,117289,2869,1908,489,1609,7410,5562,2683,4853,7048,391211,81469,2280,2665,51564,4609,23596,3952,504189,2771,4543,127066,1298,2912,7089,157506,11069,4242,8630,6016,154,5605,127385,553,747,5699,51422,64407,56937,3091,57113,2886,171177,116985,5332,121214,723961,346528,6870,5321,3292,7189,1839,154810,29984,2840,6195,10928,5894,552,338662,54509,1241,2783,5139,5331,1399,9340,127064,6464,26476,9110,5899,51377,9306,283092,54106,5144,8111,3815,56477,285659,53637,127074,3710,867,3630,3363,2534,122706,5525,9759,10046,6400,2779,2887,3084,64220,657,127059,9612,3358,6929,7472,284521,57142,6000,9252,6714,26575,5781,5593,5539,2065,1385,6885,623,4091,10253,84432,4851,23380,401992,56034,10451,7050,116984,5829,2648,7058,9568,1906,5045,2786,5747,9901,81448,2768,8787,9146,391195,183,51741,7027,2914,1211,2852,7855,165140,1234,6370,5731,398,142678,5724,261734,29933,942,2769,9002,1432,80834,92737,440153,115703,30011,84894,4992,3352,431704,3814,5696,57121,4790,9241,5664,343171,148,9754,5567,6453,5159,4690,10287,4192,58480,343173,3576,5959,6093,5528,8992,27327,403257,7433,7323,64411,2335,11255,7094,5900,90423,29924,4205,2492,23239,5997,2688,147,6788,6846,3000,1291,254879,2978,9114,5029,339403,613,23370,6755,347148,23286,9672,7477,4804,1956,2248,54361,3643,23645,4792,23221,121512,6907,117,143496,1812,5564,54567,2475,5721,26693,79885,58504,11211,4647,336,57105,5732,5949,11344,151056,2532,27237,25759,8651,5518,4157,8620,26245,8503,55294,1212,85397,2241,283869,10076,5777,1132,1846,257106,9021,2015,2916,10312,23118,26188,51291,6778,1978,396,346562,6001,388585,7088,5158,81466,8525,9826,8874,2520,5948,7046,504191,4650,5996,84144,9734,5583,2261,1124,134,3625,2793,5618,5580,441933,9181,3717,51764,6774,6667,6199,6868,81470,6364,79718,3164,5739,5575,57016,9743,4221,5138,2913,9227,391191,83478,553158,221955,64333,111,26281,6469,408,113878,528,7434,3265,3269	ARHGAP26,MTNR1B,PSMA3,TSC2,NRG2,CCL17,LPAR3,EEF2K,SKI,CDK5,RGS12,HTR6,DNM2,RAPGEF3,PPP1CA,CASR,TIAM1,ARHGAP8,MLST8,OR2L3,UBA52,OR6F1,OR1D5,OR2T35,PRKAR2B,OR11H2,ABR,PGF,PLCG1,SMAD2,CCR4,AXIN1,LHB,GSK3B,ATP6V0C,TFDP2,STARD13,MEF2C,P2RY11,OR2A7,NMT1,PSMB1,KAT2B,ACKR3,RHOC,TRIO,OR2T8,TRH,TJP1,NTSR2,COL6A3,JUN,TJP2,SH2B3,SLC26A10,RAC2,DRD5,SQSTM1,FLT4,PIK3R5,WNT10A,FAM13B,CCL4,SRGAP1,GALR1,CHRM3,LRP12,RAPGEF1,MAPKAPK3,EPS15L1,S1PR3,PSMA4,GNA11,RHOB,OR10J3,TACR2,SH2B2,STAM2,RFNG,CDK9,AP2A1,ITPR1,TAS2R41,CD97,VWF,OR2W5,CD28,RHOG,BTC,MAP2K5,DNM3,LFNG,XCL1,SCTR,RGS20,APC,HCAR2,ST3GAL6,PRKACA,APP,CCND1,NMUR2,PSMD14,RGS9BP,PRR5,ADCY7,ATP6V1G1,ARHGAP11B,FZD1,ADRA2C,COL6A2,GSK3A,ECT2,E2F3,ADCY1,FOXH1,OR4F16,WNT11,MAG,FGFR1,PPP2CA,PPP2R5E,XPO1,OR14A16,PRKCZ,FSTL3,SKP1,RPS6KB1,RGS14,OR4C46,GRK1,LRP8,MAPK12,TNRC6C,FZD8,OR2Z1,SDC4,P2RY1,PRLH,ADORA2B,RAMP1,PSMF1,HRH2,PLEKHG5,CRHR2,TMED5,IRAK1,ROCK1P1,MCF2L,PRDM4,THEM4,ARHGEF1,ARHGAP1,MAPK11,WWP1,FES,WNT9B,PDPK1,AMOTL2,FGF9,HTR1E,EIF4B,ARHGAP39,PIK3R1,OR2T1,PSMD4,NEURL1B,HTR4,IRS4,UBC,TRIB3,GPR55,AKT3,WNT5B,GPR39,STAT5A,PSME3,TRHR,BTRC,AGRN,STRADA,NLK,F11R,CDKN1A,HDAC6,SDC1,ATP6V1B1,AP2A2,OR2T27,RAMP3,RPS6KA2,PDE1A,ARHGAP19,OR2T5,DLL1,CTNNB1,SHC3,PDE6A,PFN1,PIK3R2,PSMC2,ADCY3,SSTR4,EIF4E,C3,F2,CD55,OR2M2,APH1A,RBX1,WNT7A,NTRK1,VEGFA,NFATC1,CDK1,RHEB,GNA14,RALA,EIF4G1,CLPS,GNB4,NPY4R,PPP3CC,OR10A5,DVL1,PLEKHG2,NUMB,USP15,PRKAA2,NPY2R,SMAD7,NPBWR2,CHEK1,HDAC10,THBS3,RAB6A,DHRS3,OR2A4,BMP2,OR4D9,PDE10A,OR2T34,ADCY6,MAML1,ATP6V1H,WNT3A,PLCB2,OR2C3,PSMA5,DLK1,FGFR4,OR4C3,WNT9A,TLE3,OR11L1,FGF22,HDAC3,NMUR1,OBSCN,STRADB,KRAS,PDE8A,TCF7,S1PR4,SCRIB,TCF7L2,PSMC4,MAPKAPK2,OPN1MW,HEYL,DTX1,LPAR6,NTRK2,RGS4,COL4A2,OR10R2,PTH1R,NTSR1,DGKA,PDE1C,ERBB2,DGKD,LYN,PLXNB1,VPS35,OR4N4,VAV1,PDGFA,ATP6V0B,PSMA6,JAG1,GNAZ,IKBKB,FGD3,OR2M3,RHOJ,GPC1,DVL2,CAMK2A,NPB,AKT1,PARP1,FGF4,OR4F4,PTCH1,AKAP13,LHCGR,VANGL2,DNAJC25,ST3GAL3,NEURL1,FGF1,SMAD3,EDN2,NRG3,WNT6,RXFP1,RBL1,PSMD3,DGKI,FLT1,ARHGAP4,SMAD4,PARD3,MMP9,COL9A3,LPAR2,CCR7,SORCS3,AGO2,GNAL,RLBP1,CHRM1,MAPKAP1,JAG2,NPFFR1,CSNK1A1,DRD4,NRP2,FZD6,PTPN1,SNX3,JUNB,OR11H1,PTGDR2,HSP90AA1,GREM2,SYK,ADRA2A,TUBB3,PCSK6,TLE4,HES1,PSMB4,OR2B11,PRICKLE1,ARHGEF12,ADAM12,BCAR1,RHOT2,GRM7,FGF18,ATP6V1G3,OPRL1,NPS,RBPJ,OR14I1,ARHGAP23,OPN4,ARHGEF4,MCHR1,CGN,HSPG2,PRKAB2,OR2T29,LDLR,DLC1,GNB1,SMAD5,YWHAE,PRKCA,PDE4C,OR4F3,RAC3,DAAM1,OR2M7,RPTOR,ST3GAL4,OXGR1,RNF41,GCGR,PIK3CA,DUSP7,GLP1R,HMHA1,GNG7,SAV1,PRKAG3,WNT8A,SUCNR1,BAMBI,CCNT1,ADCY8,PSMD8,OPN1MW2,RGS11,OR6K3,OR2A42,TAS1R3,KITLG,SERPINE1,NRP1,GPBAR1,HDAC2,FGD1,GRAP,TAGAP,GRK5,EDN3,ATP2A3,DGKQ,VAV2,PRKAA1,B4GALT1,NOTCH2,TGFBR2,OR2G6,OR2G3,FKBP1A,GDI2,HDAC7,MYC,OPN3,LEP,OR8U8,GNAI2,MTNR1A,OR14C36,COL9A2,GRM2,TLE2,RDH10,RAPGEF4,MFNG,HSD17B6,RIT1,ADRB2,MAP2K2,OR10J5,AVPR1B,DAGLA,PSMB10,PRKAG2,RGS18,PMEPA1,HIF1A,TRPC7,GRB7,RHOV,ARAP1,PLCB4,SDR9C7,INS-IGF2,OR2A1,TACR3,PLA2G4A,HSD17B1,TRAF6,HBEGF,AMOTL1,RHOD,GPR17,RPS6KA1,RALBP1,RAF1,AVPR1A,OR8D4,RHOF,LTB4R,GNB2,PDE3A,PLCB3,CRKL,GLP2R,OR2T12,SHC1,OR10J1,MTMR4,RALB,UCHL5,SOCS6,OR4C13,TLR9,PDE4D,GPR68,KIT,CCL28,OR2V2,S1PR5,OR2T4,ITPR3,CBL,INS,HTR7,FYN,PSMB11,PPP2R5A,HDAC4,MAMLD1,SEL1L,GNAT1,GRB10,NRG1,STRA6,BMPR1A,OR2M5,NCOR2,HTR2C,TCF3,WNT2,OR2L13,RTN4,RGS7,RPS6KA5,SRC,RGS17,PTPN11,PRKG2,PPY,ERBB3,CREB1,MAP3K7,BDKRB1,SMAD6,SPRY2,PROK1,NOTCH1,SRGAP2,OR2T2,PDGFC,VAV3,TGIF1,ARAP2,PXN,KAT2A,THBS2,GABBR2,EDN1,FURIN,GNG4,PTK2,SRGAP3,OR6K2,GNA12,RGS9,HGS,OR2T33,AGT,WWOX,TFDP1,GRM4,CLTA,GPER1,FZD5,OXER1,CCR5,CCL25,PTGER1,ARHGDIG,MIB2,PTAFR,NPHP4,GPR132,CD86,GNA15,F2RL3,MAPK14,TAS1R2,DNER,OR11H12,ARHGAP33,SH3KBP1,LINGO1,OR1F1,HTR1D,RGS21,KISS1,PSMB8,LPAR5,NFKB1,NOG,PSEN2,OR2W3,ADRA1A,STARD8,PRKACB,ITSN1,PDGFRB,NCK1,RGS19,MDK,RHOU,OR2T3,IL8,RDH5,ROCK1,PPP2R5D,ATP6V0E1,TNRC6A,OR4C45,VIPR1,UBE2D3,ARAP3,FN1,HRH3,TLN1,RALGDS,ATP6V1E2,EPN1,MEF2A,FSHR,PHLPP1,RGS2,GH1,ADRA1B,STK3,XCL2,GUCY2D,COL6A1,OR2T6,GUCA1A,ATP6V0D1,P2RY2,RXFP4,BCR,ARHGEF18,SSTR5,QRFP,WWC1,SDC3,WNT7B,NGFR,EGFR,FGF3,WNT4,INSR,PPP1R15A,NFKBIA,RHOBTB2,FGD4,TBL1X,ADCYAP1R1,OR52B4,DRD1,PRKAB1,DLL4,MTOR,PSME2,OR2V1,HDAC11,ARHGAP22,FZD10,MYO7A,APOA2,CYSLTR2,PTGER2,RBP3,TWF2,PLB1,DARC,ARHGEF16,SHC2,SOCS1,PPP2R1A,MC1R,NPFF,OR2M4,PIK3R3,FBXW7,CLTB,RGS8,FER,NPW,PTPRU,PTPN6,CHRM4,DUSP4,ARHGAP30,SOCS3,EMR1,GRM6,TCIRG1,TAB2,OR1C1,GMIP,STAT6,EIF4EBP1,ARHGDIA,GNAT3,RGS10,HES5,TLE1,PDE6B,OR2L5,DGKZ,ARHGEF11,ARHGEF7,GAST,RBP2,TGFBR1,OR9G9,MYO9B,RGS1,SYDE2,HDAC9,PRKCH,FGFR3,CHN2,ADORA1,INHBB,GNGT2,PRLR,PRKCD,OR13G1,ARHGEF2,JAK2,GNG13,STAT3,SP1,RPS6KB2,ADAM17,OR2G2,CCL20,TBL1XR1,NR4A1,PTGIR,PRKAR1B,AKR1B10,ARHGAP32,MEN1,PDE2A,GRM3,LRAT,OR2AK2,ARHGAP24,PRR5-ARHGAP8,DAGLB,ARHGAP9,ADCY5,FGF20,SHH,ARRB1,DTX2,ATP6V1C1,VIPR2,HRAS,HRH1
REACT_75925	Amyloids	0.999635204069835	-0.00036486248438702	85	23	0.00727157761618716	3163	7167	126961,3339,8370,4240,85236,8349,567,3021,8358,8970,7045,351,3630,2934,1471,653604,8337,723961,8338,3020,128312,3017,333932	HIST2H3C,HSPG2,HIST2H4A,MFGE8,HIST1H2BK,HIST2H2BE,B2M,H3F3B,HIST1H3B,HIST1H2BJ,TGFBI,APP,INS,GSN,CST3,HIST2H3D,HIST2H2AA3,INS-IGF2,HIST2H2AC,H3F3A,HIST3H2BB,HIST1H2BD,HIST2H3A
REACT_115897	Beta defensins	0.999645506045458	-0.000354556802377544	40	8	0.00252924438823901	3163	7167	245929,245915,414325,613211,613210,503618,55894,644414	DEFB115,DEFB112,DEFB103A,DEFB134,DEFB136,DEFB104B,DEFB103B,DEFB131
REACT_2232	RNA Polymerase I Promoter Opening	0.999767503080463	-0.000232523951135255	63	15	0.00474233322794815	3163	7167	126961,8370,8932,85236,653604,8349,8337,3021,8358,8970,128312,8338,3020,3017,333932	HIST2H3C,HIST2H4A,MBD2,HIST1H2BK,HIST2H3D,HIST2H2BE,HIST2H2AA3,H3F3B,HIST1H3B,HIST1H2BJ,HIST3H2BB,HIST2H2AC,H3F3A,HIST1H2BD,HIST2H3A
REACT_2159	Eukaryotic Translation Initiation	0.999780127434166	-0.000219896741350026	169	53	0.0167562440720835	3163	7167	6202,8663,6181,8664,1964,6235,285596,3646,23521,6135,6137,6234,6141,6205,6170,1983,1977,26986,6159,6154,7311,1975,6160,6132,6169,6229,6142,6232,1973,4736,8890,7458,8666,6203,3921,8667,6189,25873,6191,27335,1981,6161,1968,6208,1978,6176,6223,8892,6206,6146,8662,8891,6188	RPS8,EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,EIF5,EIF4E,PABPC1,RPL29,RPL26,UBA52,EIF4B,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,EIF4A1,RPL10A,EIF2B4,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPL36,RPS4X,EIF3K,EIF4G1,RPL32,EIF2S3,RPS14,EIF4EBP1,RPLP1,RPS19,EIF2B2,RPS12,RPL22,EIF3B,EIF2B3,RPS3
REACT_2099	Cap-dependent Translation Initiation	0.999780127434166	-0.000219896741350026	169	53	0.0167562440720835	3163	7167	6202,8663,6181,8664,1964,6235,285596,3646,23521,6135,6137,6234,6141,6205,6170,1983,1977,26986,6159,6154,7311,1975,6160,6132,6169,6229,6142,6232,1973,4736,8890,7458,8666,6203,3921,8667,6189,25873,6191,27335,1981,6161,1968,6208,1978,6176,6223,8892,6206,6146,8662,8891,6188	RPS8,EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,EIF5,EIF4E,PABPC1,RPL29,RPL26,UBA52,EIF4B,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,EIF4A1,RPL10A,EIF2B4,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPL36,RPS4X,EIF3K,EIF4G1,RPL32,EIF2S3,RPS14,EIF4EBP1,RPLP1,RPS19,EIF2B2,RPS12,RPL22,EIF3B,EIF2B3,RPS3
REACT_27271	Meiotic Recombination	0.999800896674647	-0.000199123149051747	87	23	0.00727157761618716	3163	7167	126961,8370,1019,56979,85236,4439,8349,3021,8358,8970,672,641,8290,6118,10111,653604,472,8337,128312,8338,3020,3017,333932	HIST2H3C,HIST2H4A,CDK4,PRDM9,HIST1H2BK,MSH5,HIST2H2BE,H3F3B,HIST1H3B,HIST1H2BJ,BRCA1,BLM,HIST3H3,RPA2,RAD50,HIST2H3D,ATM,HIST2H2AA3,HIST3H2BB,HIST2H2AC,H3F3A,HIST1H2BD,HIST2H3A
REACT_21340	GPCR ligand binding	0.999818026651337	-0.000181989907821628	445	161	0.0509010433133101	3163	7167	5724,29933,4544,2782,9002,6361,80834,23566,3352,3814,10268,57121,2642,27199,3362,6754,846,148,718,2147,1604,2740,2788,7476,7478,56670,1233,59345,728458,3576,5540,3972,83756,151306,5032,11255,1908,57007,4887,2832,7200,23620,2492,147,1816,6846,80326,6351,23596,2587,89780,4543,1131,5029,2912,339403,6755,7483,347148,1903,10316,7477,8698,154,553,54361,2652,6865,10161,259287,976,117,6870,1812,5745,6375,552,2840,4923,11211,6344,57105,5732,338442,1241,2783,2532,351,9340,56923,4157,8620,8111,8321,152,256933,56477,283869,53637,5727,1132,7481,3973,548645,2015,3363,2916,1907,7475,59350,9170,3358,1236,8325,7472,1128,136,51052,5028,64106,10267,8323,3274,1815,1395,134,2793,11251,51764,5539,623,7484,84432,10381,150,3354,6364,9568,5739,1906,2786,2913,3360,183,9290,2917,6469,2914,4987,2863,2852,594857,7855,7201,165140,94233,1234,3269,6370,5731,2847	PTAFR,GPR132,MTNR1B,GNB1,F2RL3,CCL17,TAS1R2,LPAR3,HTR1D,KISS1,RAMP3,LPAR5,GCGR,OXGR1,HTR6,SSTR4,CASR,ADRA1A,C3,F2,CD55,GLP1R,GNG7,WNT7A,WNT8A,SUCNR1,CCR4,GNB4,OPN1MW2,IL8,NPY4R,LHB,TAS1R3,GPBAR1,P2RY11,HRH3,EDN3,ACKR3,NPY2R,NPBWR2,TRH,NTSR2,FSHR,ADRA1B,DRD5,XCL2,WNT10A,CCL4,OPN3,GALR1,WNT3A,MTNR1A,CHRM3,P2RY2,GRM2,RXFP4,SSTR5,WNT9A,QRFP,S1PR3,NMUR1,WNT7B,S1PR4,ADRB2,AVPR1B,WNT4,OPN1MW,TACR2,LPAR6,TAS2R41,CD97,ADCYAP1R1,TACR3,DRD1,PTH1R,XCL1,AVPR1A,GPR17,NTSR1,FZD10,SCTR,CYSLTR2,PTGER2,HCAR2,LTB4R,GNB2,DARC,APP,GLP2R,NMUR2,MC1R,NPFF,GPR68,FZD1,ADRA2C,NPB,CCL28,NPW,S1PR5,PTCH1,CHRM4,WNT11,LHCGR,DNAJC25,EMR1,HTR7,GRM6,EDN2,WNT6,RXFP1,LPAR2,HTR2C,CCR7,FZD8,WNT2,CHRM1,ADORA2B,PRLH,P2RY1,NPFFR1,RAMP1,FZD6,HRH2,DRD4,CRHR2,ADORA1,GNGT2,PTGDR2,GNG13,PPY,BDKRB1,WNT9B,PROK1,TUBB3,ADRA2A,HTR1E,CCL20,GABBR2,PTGIR,EDN1,GNG4,GRM3,HTR4,AGT,GPR55,GRM7,SHH,GRM4,OPRL1,GPR39,GPER1,NPS,FZD5,TRHR,OXER1,OPN4,CCR5,HRH1,CCL25,PTGER1,MCHR1
REACT_1014	Translation	0.999826882054331	-0.000173132932310451	207	67	0.0211824217515017	3163	7167	8663,6181,8664,1964,6235,285596,3646,6135,6745,58477,23478,6141,2107,1983,1977,55176,6159,7311,6160,6169,6142,6232,4736,8666,6203,3921,8667,6191,27335,1981,29927,1650,1978,6208,6176,6146,8662,6188,8891,6202,23480,6748,1915,23521,6137,6184,6234,6205,6170,26986,1936,6154,1975,6132,6229,6746,1973,8890,7458,25873,6189,6726,6161,1968,6223,8892,6206	EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL11,SSR1,SRPRB,SEC11A,RPL18,ETF1,EIF5,EIF4E,SEC61A2,RPL29,UBA52,RPL31,RPL38,RPL18A,RPS27,RPL10A,EIF3G,RPS9,RPSA,EIF3H,RPS4X,EIF3K,EIF4G1,SEC61A1,DDOST,EIF4EBP1,RPS14,RPLP1,RPL22,EIF3B,RPS3,EIF2B3,RPS8,SEC61G,SSR4,EEF1A1,RPL13A,RPL13,RPN1,RPS28,RPS11,RPL39,PABPC1,EEF1D,RPL26,EIF4B,RPL8,RPS24,SSR2,EIF4A1,EIF2B4,EIF4H,RPL36,RPS3A,SRP9,RPL32,EIF2S3,RPS19,EIF2B2,RPS12
REACT_15344	Chemokine receptors bind chemokines	0.999896986140705	-0.000103019165587217	56	12	0.00379386658235852	3163	7167	56477,1233,6364,1236,6846,57007,6375,3576,6351,6361,1234,6370	CCL28,CCR4,CCL20,CCR7,XCL2,ACKR3,XCL1,IL8,CCL4,CCL17,CCR5,CCL25
REACT_11152	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.999899820633161	-0.000100184385127423	95	25	0.00790388871324692	3163	7167	718,2213,79465,11126,6402,567,56253,10666,3383,2214,8519,3105,3689,925,999,919,3688,10990,9103,3107,947,975,22914,80329,3802	C3,FCGR2B,ULBP3,CD160,SELL,B2M,CRTAM,CD226,ICAM1,FCGR3A,IFITM1,HLA-A,ITGB2,CD8A,CDH1,CD247,ITGB1,LILRB5,FCGR2C,HLA-C,CD34,CD81,KLRK1,ULBP1,KIR2DL1
REACT_22186	Deposition of New CENPA-containing Nucleosomes at the Centromere	0.999919168545856	-8.08347211818216e-05	66	15	0.00474233322794815	3163	7167	1058,8607,55355,8370,85236,8349,4869,8337,8970,128312,8338,8467,3017,55320,79682	CENPA,RUVBL1,HJURP,HIST2H4A,HIST1H2BK,HIST2H2BE,NPM1,HIST2H2AA3,HIST1H2BJ,HIST3H2BB,HIST2H2AC,SMARCA5,HIST1H2BD,MIS18BP1,CENPU
REACT_22344	Nucleosome assembly	0.999919168545856	-8.08347211818216e-05	66	15	0.00474233322794815	3163	7167	1058,8607,55355,8370,85236,8349,4869,8337,8970,128312,8338,8467,3017,55320,79682	CENPA,RUVBL1,HJURP,HIST2H4A,HIST1H2BK,HIST2H2BE,NPM1,HIST2H2AA3,HIST1H2BJ,HIST3H2BB,HIST2H2AC,SMARCA5,HIST1H2BD,MIS18BP1,CENPU
REACT_79	L13a-mediated translational silencing of Ceruloplasmin expression	0.9999409584977	-5.90432453183199e-05	161	48	0.0151754663294341	3163	7167	6202,8663,6181,8664,1964,6235,285596,3646,23521,6135,6137,6234,6141,6205,6170,1977,26986,6159,6154,7311,1975,6160,6132,6169,6229,6142,1973,6232,4736,7458,8666,6203,3921,8667,6189,25873,6191,27335,1981,6161,1968,6208,6223,6176,6206,6146,8662,6188	RPS8,EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,EIF4E,PABPC1,RPL29,RPL26,UBA52,EIF4B,RPL31,RPL8,RPL38,RPS24,RPL18A,EIF4A1,RPS27,RPL10A,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPL36,RPS4X,EIF3K,EIF4G1,RPL32,EIF2S3,RPS14,RPS19,RPLP1,RPS12,RPL22,EIF3B,RPS3
REACT_2085	GTP hydrolysis and joining of the 60S ribosomal subunit	0.999954197594255	-4.58034547073251e-05	162	48	0.0151754663294341	3163	7167	6202,8663,6181,8664,1964,6235,285596,3646,23521,6135,6137,6234,6141,6205,6170,1983,1977,6159,6154,7311,1975,6160,6132,6169,6229,6142,1973,6232,4736,7458,8666,6203,3921,8667,6189,25873,6191,27335,1981,6161,1968,6208,6223,6176,6206,6146,8662,6188	RPS8,EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,EIF5,EIF4E,RPL29,RPL26,UBA52,EIF4B,RPL31,RPL8,RPL38,RPS24,RPL18A,EIF4A1,RPS27,RPL10A,EIF4H,EIF3G,RPS9,RPSA,EIF3H,RPS3A,RPL36,RPS4X,EIF3K,EIF4G1,RPL32,EIF2S3,RPS14,RPS19,RPLP1,RPS12,RPL22,EIF3B,RPS3
REACT_6167	Influenza Infection	0.999968859811826	-3.11406730393365e-05	196	60	0.0189693329117926	3163	7167	6202,6181,5440,5611,3843,6235,285596,821,23521,129401,6135,11097,6137,811,6234,6141,23225,55746,6205,6170,3320,10898,79902,81929,3837,6159,6154,5438,7311,5441,6160,6132,6169,6229,6142,6232,4736,8021,6203,3921,3304,6189,25873,6191,7175,7514,5439,6161,6208,5434,6176,9688,6223,1211,5437,6206,6146,6188,8086,8106	RPS8,RPLP2,POLR2K,DNAJC3,IPO5,RPS29,FAM153A,CANX,RPL13A,NUP35,RPL11,NUPL2,RPL13,CALR,RPS28,RPL18,NUP210,NUP133,RPS11,RPL39,HSP90AA1,CPSF4,NUP85,SEH1L,KPNB1,RPL29,RPL26,POLR2I,UBA52,POLR2L,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,NUP214,RPS9,RPSA,HSPA1B,RPS3A,RPL36,RPS4X,TPR,XPO1,POLR2J,RPL32,RPS14,POLR2E,RPLP1,NUP93,RPS19,CLTA,POLR2H,RPS12,RPL22,RPS3,AAAS,PABPN1
REACT_6145	Influenza Life Cycle	0.999971567732347	-2.84326718580463e-05	191	58	0.0183370218147328	3163	7167	6202,6181,5440,5611,3843,6235,285596,821,23521,129401,6135,11097,6137,811,6234,6141,23225,55746,6205,6170,3320,79902,81929,3837,6159,6154,5438,7311,5441,6160,6132,6169,6229,6142,6232,4736,8021,6203,3921,3304,6189,25873,6191,7175,7514,5439,6161,6208,5434,6176,9688,6223,1211,5437,6206,6146,6188,8086	RPS8,RPLP2,POLR2K,DNAJC3,IPO5,RPS29,FAM153A,CANX,RPL13A,NUP35,RPL11,NUPL2,RPL13,CALR,RPS28,RPL18,NUP210,NUP133,RPS11,RPL39,HSP90AA1,NUP85,SEH1L,KPNB1,RPL29,RPL26,POLR2I,UBA52,POLR2L,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,NUP214,RPS9,RPSA,HSPA1B,RPS3A,RPL36,RPS4X,TPR,XPO1,POLR2J,RPL32,RPS14,POLR2E,RPLP1,NUP93,RPS19,CLTA,POLR2H,RPS12,RPL22,RPS3,AAAS
REACT_7956	Classical antibody-mediated complement activation	0.999979063040906	-2.09371782749459e-05	28	3	0.00094846664558963	3163	7167	713,712,714	C1QB,C1QA,C1QC
REACT_75822	Nonsense Mediated Decay Enhanced by the Exon Junction Complex	0.999991818128274	-8.18190519733977e-06	163	46	0.0145431552323743	3163	7167	6202,6181,6235,9939,285596,9887,23521,6135,6137,6234,6141,23381,5518,6205,6170,2107,26986,6159,6154,7311,6160,6132,6169,10921,6229,6142,6232,4736,6203,3921,6189,25873,5515,6191,1981,5976,6161,6208,6223,6176,22916,6206,56006,6146,6188,23049	RPS8,RPLP2,RPS29,RBM8A,FAM153A,SMG7,RPL13A,RPL11,RPL13,RPS28,RPL18,SMG5,PPP2R1A,RPS11,RPL39,ETF1,PABPC1,RPL29,RPL26,UBA52,RPL31,RPL8,RPL38,RNPS1,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPS3A,RPL36,PPP2CA,RPS4X,EIF4G1,UPF1,RPL32,RPS14,RPS19,RPLP1,NCBP2,RPS12,SMG9,RPL22,RPS3,SMG1
REACT_75886	Nonsense-Mediated Decay	0.999991818128274	-8.18190519733977e-06	163	46	0.0145431552323743	3163	7167	6202,6181,6235,9939,285596,9887,23521,6135,6137,6234,6141,23381,5518,6205,6170,2107,26986,6159,6154,7311,6160,6132,6169,10921,6229,6142,6232,4736,6203,3921,6189,25873,5515,6191,1981,5976,6161,6208,6223,6176,22916,6206,56006,6146,6188,23049	RPS8,RPLP2,RPS29,RBM8A,FAM153A,SMG7,RPL13A,RPL11,RPL13,RPS28,RPL18,SMG5,PPP2R1A,RPS11,RPL39,ETF1,PABPC1,RPL29,RPL26,UBA52,RPL31,RPL8,RPL38,RNPS1,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPS3A,RPL36,PPP2CA,RPS4X,EIF4G1,UPF1,RPL32,RPS14,RPS19,RPLP1,NCBP2,RPS12,SMG9,RPL22,RPS3,SMG1
REACT_14819	Peptide ligand-binding receptors	0.999993979155346	-6.02086277894118e-06	189	55	0.0173885551691432	3163	7167	1908,1236,4887,57007,552,6375,4923,2832,7200,23620,9002,51052,6361,64106,351,2532,3814,56923,6846,4157,8620,6351,5539,2587,6754,623,84432,10381,339403,718,2147,256933,56477,283869,6755,6364,347148,1906,10316,553,1907,6865,1233,183,59350,3576,5540,4987,2852,594857,7201,1234,6370,6870,2847	EDN3,CCR7,NPY2R,ACKR3,AVPR1A,XCL1,NTSR1,NPBWR2,TRH,NTSR2,F2RL3,PRLH,CCL17,NPFFR1,APP,DARC,KISS1,NMUR2,XCL2,MC1R,NPFF,CCL4,PPY,GALR1,SSTR4,BDKRB1,PROK1,TUBB3,RXFP4,C3,F2,NPB,CCL28,NPW,SSTR5,CCL20,QRFP,EDN1,NMUR1,AVPR1B,EDN2,TACR2,CCR4,AGT,RXFP1,IL8,NPY4R,OPRL1,GPER1,NPS,TRHR,CCR5,CCL25,TACR3,MCHR1
REACT_12627	Generic Transcription Pathway	0.999994401710895	-5.59830477563866e-06	486	169	0.0534302877015492	3163	7167	84838,90576,6256,7692,79943,125919,6497,80108,85441,2516,284459,7004,7551,10498,79755,80205,7678,7311,7561,7748,340252,2649,79970,199692,9969,7101,4087,10520,26974,55663,10224,904,115509,5054,7029,93474,3172,124411,7323,860,84626,8850,219749,4092,4853,255403,7633,339500,6940,84246,4609,7625,55657,92285,9443,9794,58500,342132,7760,170959,340385,84775,91975,56979,148156,100131827,7582,2103,27153,1025,51586,221785,80264,9970,4929,9440,6907,2101,388567,126382,9534,51123,285676,51276,7067,92595,6095,79818,285971,9441,117608,7539,10794,9572,90075,90390,26152,147949,5914,142,26048,29982,10025,7697,286075,10155,7421,4088,8427,152687,162655,5933,90592,79230,80139,10046,619279,80818,100129543,197320,7549,96764,4306,4089,51385,728927,9612,136051,201514,442319,51333,9422,30832,168374,7988,57209,3726,344787,374655,441234,10499,6667,6097,4851,7050,9439,440519,7738,6258,2648,79718,3174,2908,2104,3164,9971,79862,4221,148206,2494,55422,7316,80778,58492,57335,7027,126231,3516,169270	ZNF496,ZNF799,RXRA,ZNF133,ZNF696,ZNF543,SKI,ZFP2,HELZ2,NR5A1,HKR1,TEAD4,ZNF3,CARM1,ZNF750,CHD9,ZNF124,UBA52,ZNF14,ZNF195,ZNF680,NR6A1,ZNF767,ZNF627,MED13,NR2E1,SMAD2,ZNF211,ZNF285,ZNF446,ZNF443,CCNT1,ZNF689,SERPINE1,TFDP2,ZNF670,HNF4A,ZNF720,UBE2D3,RUNX2,KRBA1,KAT2B,ZNF25,SMAD7,NOTCH2,ZNF718,ZNF79,ZNF678,ZNF354A,MED10,MYC,ZNF74,ZNF692,ZNF585B,MED7,MAML1,ZNF250,ZNF774,ZNF213,ZNF431,ZNF517,ZNF607,ZNF300,PRDM9,ZNF558,ZNF717,ZNF33B,ESRRB,ZNF777,CDK9,MED15,ZSCAN25,ZNF430,NR1I3,NR4A2,MED17,TBL1X,ESRRA,ZNF749,NR2C2AP,ZNF254,ZNF706,ZNF454,ZNF571,THRA,ZNF764,RORA,ZNF552,ZNF775,MED26,ZNF354B,ZFP37,ZNF460,NR1D1,ZNF30,MED30,ZNF337,ZNF583,RARA,PARP1,ZNF500,NRBF2,MED16,ZNF138,ZNF707,TRIM28,VDR,SMAD3,ZNF282,ZNF595,ZNF519,RBL1,ZNF700,ZNF557,ZNF703,MAMLD1,ZNF704,ZNF436,ZNF730,ZNF778,ZNF2,TGS1,NR3C2,SMAD4,ZNF589,ZNF736,NCOR2,ZNF786,ZNF584,ZNF727,ZNF771,ZNF264,ZNF354C,ZNF92,ZNF212,ZNF248,JUNB,ZNF860,ZNF710,ZNF716,NCOA2,SP1,RORC,NOTCH1,TGIF1,MED23,ZNF724P,ZNF184,RXRG,KAT2A,TBL1XR1,HNF4G,NR3C1,ESRRG,NR4A1,NR1H4,ZNF669,MEN1,ZNF714,NR5A2,ZNF331,UBC,ZNF34,ZNF77,ZNF286A,TFDP1,ZNF573,RBPJ,ZNF596
REACT_1797	Formation of a pool of free 40S subunits	0.999995373674925	-4.62633577626134e-06	151	41	0.0129623774897249	3163	7167	6202,8663,6181,8664,1964,6235,285596,3646,23521,6135,6137,6234,6141,6205,6170,6154,6159,7311,6160,6132,6169,6229,6142,6232,4736,8666,6203,8667,3921,6189,25873,27335,6191,6161,6208,6223,6176,6206,6188,8662,6146	RPS8,EIF3C,RPLP2,EIF3D,EIF1AX,RPS29,FAM153A,EIF3E,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,RPL26,RPL29,UBA52,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,EIF3G,RPS9,EIF3H,RPSA,RPS3A,RPL36,EIF3K,RPS4X,RPL32,RPS14,RPS19,RPLP1,RPS12,RPS3,EIF3B,RPL22
REACT_6152	Influenza Viral RNA Transcription and Replication	0.99999753419908	-2.4658039603549e-06	156	42	0.0132785330382548	3163	7167	6202,6181,5440,5611,3843,6235,285596,23521,6135,6137,6234,6141,6205,6170,3320,6154,6159,5438,7311,5441,6160,6132,6169,6229,6142,6232,4736,6203,3921,6189,25873,6191,6161,5439,6208,6223,6176,5434,5437,6206,6188,6146	RPS8,RPLP2,POLR2K,DNAJC3,IPO5,RPS29,FAM153A,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,HSP90AA1,RPL26,RPL29,POLR2I,UBA52,POLR2L,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPS3A,RPL36,RPS4X,RPL32,POLR2J,RPS14,RPS19,RPLP1,POLR2E,POLR2H,RPS12,RPS3,RPL22
REACT_75768	Nonsense Mediated Decay Independent of the Exon Junction Complex	0.999997823403092	-2.17659927645507e-06	145	38	0.0120139108441353	3163	7167	6202,6181,6235,285596,23521,6135,6137,6234,6141,6205,6170,2107,26986,6154,6159,7311,6160,6132,6169,6229,6142,6232,4736,6203,3921,6189,25873,6191,1981,5976,6161,6208,6223,6176,22916,6206,6188,6146	RPS8,RPLP2,RPS29,FAM153A,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,ETF1,PABPC1,RPL26,RPL29,UBA52,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPS3A,RPL36,RPS4X,EIF4G1,UPF1,RPL32,RPS14,RPS19,RPLP1,NCBP2,RPS12,RPS3,RPL22
REACT_115902	SRP-dependent cotranslational protein targeting to membrane	0.999999067181741	-9.3281869412996e-07	165	44	0.0139108441353146	3163	7167	6202,6181,23480,6235,285596,6748,23521,6135,6745,58477,23478,6137,6184,6234,6141,6205,6170,55176,6159,6154,7311,6160,6132,6169,6746,6229,6142,6232,4736,6203,3921,6189,25873,6191,6726,1650,6161,29927,6208,6223,6176,6206,6146,6188	RPS8,RPLP2,SEC61G,RPS29,FAM153A,SSR4,RPL13A,RPL11,SSR1,SRPRB,SEC11A,RPL13,RPN1,RPS28,RPL18,RPS11,RPL39,SEC61A2,RPL29,RPL26,UBA52,RPL31,RPL8,RPL38,SSR2,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPS3A,RPL36,RPS4X,SRP9,DDOST,RPL32,SEC61A1,RPS14,RPS19,RPLP1,RPS12,RPL22,RPS3
REACT_71	Gene Expression	0.999999081753039	-9.18247382779827e-07	1201	456	0.144166930129624	3163	7167	84838,5684,23019,134353,1964,57505,8349,5578,51728,125919,54938,6497,85441,6632,29894,2516,7004,81929,7311,2649,3312,6924,3185,3021,10421,6827,4087,10520,904,5714,115509,6208,55290,1615,5054,5437,8337,56006,2972,128312,7029,6188,3315,11178,3172,3066,8086,124411,833,6627,3178,5689,64216,84626,8850,5440,23480,219749,1660,8970,4853,7702,6748,255403,7633,5073,56339,23521,51067,4849,129401,6137,6184,339500,6170,4609,92285,10419,58500,79902,26986,1936,79587,104,2976,7760,57459,2967,170959,340385,6154,79101,84775,9219,51639,6229,6746,7469,7458,148156,8175,219988,5685,167227,7582,6726,2058,5699,27153,5439,2957,10919,1025,51586,6223,9688,221785,9970,8892,4929,57472,9440,2101,388567,9534,7067,8664,10978,92595,6095,220988,79818,285971,23381,9112,56915,117608,10213,103,9572,90390,90075,25920,6881,902,8370,5441,29982,5725,10921,3183,6169,6232,10025,10155,4784,7421,27335,6191,5515,8427,122706,7514,162655,29927,1650,54487,11157,80139,10046,55718,27068,8243,6176,619279,100129543,197320,2521,7549,4306,3842,728927,9612,136051,57690,6908,442319,201514,51333,9422,6431,4799,10667,25804,1915,9491,168374,661,284119,3184,55802,23438,5600,54512,374655,7965,10499,6097,4851,7738,6258,7050,9439,440519,2648,1975,9328,6132,6895,1973,5710,148206,7316,9015,5917,6161,1968,23405,7027,126231,8570,1478,10197,51808,126961,8663,90576,9337,6256,9939,3646,8358,7692,1432,6621,83443,79943,9924,6745,10914,10992,58477,80108,23225,6427,5696,6141,84844,5701,284459,27257,1983,3192,7551,1977,55749,10498,79755,55176,80205,51520,7678,7561,7748,340252,6628,6160,85236,8575,4736,79970,199692,9969,7101,25929,1981,26974,10262,55663,10224,55699,9128,93474,8106,27327,5442,7323,860,4092,10949,9887,677,3187,11097,8178,2961,84246,6940,6205,8932,7625,55657,4904,9443,9794,5686,342132,10352,5438,91975,56979,6921,80222,100131827,5704,25873,9261,2103,5434,80264,7534,6907,6625,79869,333932,126382,51123,285676,6181,51276,5721,6235,285596,6635,85456,6135,23478,5687,9441,2968,5518,55746,3191,7539,2107,10056,10794,3017,26152,147949,1477,79731,6159,5914,6923,142,207,26048,4677,5451,6142,11100,51585,6618,7697,10907,8021,53615,8666,286075,6203,3921,8667,6426,4088,57794,152687,25904,90592,5933,10236,5709,79230,1978,80818,55157,8662,6146,3020,8338,8891,96764,51385,9521,4089,23049,9785,6202,9150,7978,10250,27161,30832,7407,10644,7988,54815,6234,57209,9014,10189,3726,5580,653604,344787,441234,10302,6667,5692,2908,79718,3174,2104,3164,9971,79862,84265,4221,8890,2494,55422,6897,3304,6189,7175,80778,58492,5976,57335,6418,6874,22916,4782,3516,6206,169270	ZNF496,PSMA3,CNOT1,LSM11,EIF1AX,AARS2,HIST2H2BE,PRKCA,POLR3K,ZNF543,SARS2,SKI,HELZ2,SNRPD1,CPSF1,NR5A1,TEAD4,SEH1L,UBA52,NR6A1,HSPA8,TCEB3,HNRNPF,H3F3B,CD2BP2,SUPT4H1,SMAD2,ZNF211,CCNT1,PSMD8,ZNF689,RPS14,BRF2,DARS,SERPINE1,POLR2H,HIST2H2AA3,SMG9,BRF1,HIST3H2BB,TFDP2,RPS3,HSPB1,LZTS1,HNF4A,HDAC2,AAAS,ZNF720,CARS,SNRPA1,HNRNPA1,PSMB1,TFB2M,KRBA1,KAT2B,POLR2K,SEC61G,ZNF25,DHX9,HIST1H2BJ,NOTCH2,ZNF143,SSR4,ZNF718,ZNF79,PARN,METTL3,RPL13A,YARS2,CNOT3,NUP35,RPL13,RPN1,ZNF678,RPL39,MYC,ZNF585B,PRMT5,ZNF250,NUP85,PABPC1,EEF1D,CARS2,ADARB1,GTF3C2,ZNF213,GATAD2B,GTF2H3,ZNF431,ZNF517,RPL26,TAF1D,ZNF607,MTA2,SF3B14,RPS24,SSR2,NELFA,EIF4H,ZNF558,SF3A2,PATL1,PSMA4,DCP2,ZNF33B,SRP9,EPRS,PSMB10,ZNF777,POLR2J,GTF2A1,EHMT2,CDK9,MED15,RPS19,NUP93,ZSCAN25,NR1I3,EIF2B2,NR4A2,CNOT6,MED17,ESRRA,ZNF749,ZNF254,THRA,EIF3D,CLP1,ZNF764,RORA,HNRNPA3,ZNF552,ZNF775,SMG5,MTA1,EXOSC5,ZNF354B,PSMD14,ADAR,NR1D1,MED30,ZNF30,NELFB,TAF10,CCNH,HIST2H4A,POLR2L,NRBF2,PTBP1,RNPS1,HNRNPC,RPL38,RPS27,MED16,TRIM28,NFIX,VDR,EIF3K,RPS4X,PPP2CA,ZNF282,PSMB11,XPO1,ZNF519,SEC61A1,DDOST,DGCR8,LSM6,ZNF703,MAMLD1,POLR3E,PPA2,SMC1A,RPLP1,ZNF704,ZNF730,ZNF778,FUS,ZNF2,NR3C2,TNPO1,ZNF736,NCOR2,ZNF786,TNRC6C,TBP,ZNF727,ZNF584,ZNF771,ZNF264,SRSF6,NFX1,FARS2,LSM4,EEF1A1,PSMF1,ZNF92,POLR3D,PTRF,HNRNPD,DCP1A,HARS2,MAPK11,EXOSC4,ZNF710,AIMP2,NCOA2,RORC,NOTCH1,ZNF184,RXRG,TGIF1,MED23,ZNF724P,KAT2A,EIF4B,GTF3C5,RPL8,TARBP2,EIF4A1,PSMD4,ZNF714,UBC,TAF1A,RARS,RPL32,EIF2S3,DICER1,TFDP1,ZNF573,KHSRP,CSTF2,PSME3,PHAX,HIST2H3C,EIF3C,ZNF799,CNOT8,RXRA,RBM8A,EIF3E,HIST1H3B,ZNF133,MAPK14,SNAPC4,SF3B5,ZNF696,PAN2,SSR1,PAPOLA,SF3B2,SRPRB,ZFP2,NUP210,SRSF2,PSMB8,RPL18,PHF5A,PSMC2,HKR1,LSM1,EIF5,HNRNPU,ZNF3,EIF4E,CCAR1,CARM1,ZNF750,SEC61A2,CHD9,LARS,ZNF124,ZNF14,ZNF195,ZNF680,SNRPB,RPL31,HIST1H2BK,PRKRA,RPL10A,ZNF767,ZNF627,MED13,NR2E1,GEMIN5,EIF4G1,ZNF285,SF3B4,ZNF446,ZNF443,IARS2,PRPF4,ZNF670,PABPN1,TNRC6A,POLRMT,UBE2D3,RUNX2,SMAD7,HNRNPA0,SMG7,ZFP36L1,HNRNPH1,NUPL2,ELL,GTF2E2,MED10,ZNF354A,RPS11,MBD2,ZNF74,ZNF692,YBX1,MED7,MAML1,PSMA5,ZNF774,WARS2,POLR2I,ZNF300,PRDM9,TCEB1,TARS2,ZNF717,PSMC4,RPL36,MAPKAPK2,ESRRB,POLR2E,ZNF430,YWHAZ,TBL1X,SNRNP70,CPSF7,HIST2H3A,NR2C2AP,ZNF706,ZNF454,RPLP2,ZNF571,PSME2,RPS29,FAM153A,SNRPE,TNKS1BP1,RPL11,SEC11A,PSMA6,MED26,GTF2H4,PPP2R1A,NUP133,HNRNPL,ZFP37,ETF1,FARSB,ZNF460,HIST1H2BD,ZNF337,ZNF583,CSTF1,NARS2,RPL29,RARA,TCEB2,PARP1,AKT1,ZNF500,NARS,POU2F1,RPL18A,HNRNPUL1,PCF11,SNAPC2,ZNF138,TXNL4A,NUP214,MBD3,EIF3G,ZNF707,RPS9,RPSA,EIF3H,SRSF1,SMAD3,SUGP1,ZNF595,CNOT10,ZNF700,RBL1,HNRNPR,PSMD3,ZNF557,EIF4EBP1,ZNF436,DARS2,EIF3B,RPL22,H3F3A,HIST2H2AC,EIF2B3,TGS1,ZNF589,EEF1E1,SMAD4,SMG1,DHX38,RPS8,CTDP1,MTERF,SRRM1,AGO2,ZNF354C,VARS,IGF2BP2,ZNF212,GATAD2A,RPS28,ZNF248,TAF1B,ALYREF,JUNB,PRKCD,HIST2H3D,ZNF860,ZNF716,SNAPC5,SP1,PSMB4,NR3C1,TBL1XR1,HNF4G,ESRRG,NR4A1,NR1H4,ZNF669,POLR3GL,MEN1,EIF2B4,NR5A2,ZNF331,TARS,HSPA1B,RPS3A,TPR,ZNF34,ZNF77,UPF1,ZNF286A,SET,TAF4,NCBP2,NFIC,RBPJ,RPS12,ZNF596
REACT_1986	Eukaryotic Translation Termination	0.999999732938195	-2.67061840901232e-07	140	34	0.0107492886500158	3163	7167	6202,6181,6235,285596,23521,6135,6137,6234,6141,6205,6170,2107,6154,6159,7311,6160,6169,6132,6229,6142,6232,4736,6203,3921,25873,6189,6191,6161,6208,6223,6176,6206,6188,6146	RPS8,RPLP2,RPS29,FAM153A,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,ETF1,RPL26,RPL29,UBA52,RPL31,RPL38,RPL8,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL36,RPS3A,RPS4X,RPL32,RPS14,RPS19,RPLP1,RPS12,RPS3,RPL22
REACT_9491	Viral mRNA Translation	0.999999732938195	-2.67061840901232e-07	140	34	0.0107492886500158	3163	7167	6202,6181,5611,6235,285596,23521,6135,6137,6234,6141,6205,6170,6154,6159,7311,6160,6169,6132,6229,6142,6232,4736,6203,3921,25873,6189,6191,6161,6208,6223,6176,6206,6188,6146	RPS8,RPLP2,DNAJC3,RPS29,FAM153A,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,RPL26,RPL29,UBA52,RPL31,RPL38,RPL8,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL36,RPS3A,RPS4X,RPL32,RPS14,RPS19,RPLP1,RPS12,RPS3,RPL22
REACT_1404	Peptide chain elongation	0.999999732938195	-2.67061840901232e-07	140	34	0.0107492886500158	3163	7167	6202,6181,6235,285596,1915,23521,6135,6137,6234,6141,6205,6170,6154,6159,7311,6160,6169,6132,6229,6142,6232,4736,6203,3921,25873,6189,6191,6161,6208,6223,6176,6206,6188,6146	RPS8,RPLP2,RPS29,FAM153A,EEF1A1,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,RPL26,RPL29,UBA52,RPL31,RPL38,RPL8,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL36,RPS3A,RPS4X,RPL32,RPS14,RPS19,RPLP1,RPS12,RPS3,RPL22
REACT_1477	Eukaryotic Translation Elongation	0.999999929254527	-7.07454751980406e-08	147	35	0.0110654441985457	3163	7167	6202,6181,6235,285596,1915,23521,6135,6137,6234,6141,6205,6170,1936,6154,6159,7311,6160,6132,6169,6229,6142,6232,4736,6203,3921,25873,6189,6191,6161,6208,6223,6176,6206,6188,6146	RPS8,RPLP2,RPS29,FAM153A,EEF1A1,RPL13A,RPL11,RPL13,RPS28,RPL18,RPS11,RPL39,EEF1D,RPL26,RPL29,UBA52,RPL31,RPL8,RPL38,RPS24,RPL18A,RPS27,RPL10A,RPS9,RPSA,RPL36,RPS3A,RPS4X,RPL32,RPS14,RPS19,RPLP1,RPS12,RPS3,RPL22
REACT_160163	Scavenging of Heme from Plasma	0.999999995790542	-4.20945805990115e-09	33	1	0.000316155548529877	3163	7167	259	AMBP
REACT_14797	Signaling by GPCR	0.999999999855316	-1.44683831900038e-10	1068	349	0.110338286436927	3163	7167	4544,343563,2782,6361,5578,5143,26683,23566,391196,1020,6002,2642,27199,5290,3362,5499,846,7074,391192,343169,8386,2740,2788,403244,5577,79334,29,7478,56670,1233,114,8786,728458,391114,3972,402317,83756,151306,2245,5032,401427,2869,1908,57007,389,1609,7410,7204,343172,7200,23620,391211,81469,65012,5880,1816,23533,80326,6351,23596,504189,2587,2771,4543,127066,1131,2912,1903,154,5605,2767,127385,388,441911,553,747,64407,6865,3708,57113,259287,5332,976,441932,346528,6870,5321,391,1839,2840,6195,6375,5894,552,6344,8601,338662,338442,1241,5566,2783,351,5139,5331,9340,127064,56923,26476,283092,5144,8111,113,8321,152,56477,285659,53637,1894,107,81399,7481,127074,3710,3363,5515,284532,2779,10636,119749,127059,3358,8325,7472,284383,284521,5028,136,51052,6000,10267,3274,26575,57449,1395,727758,23263,9138,5539,1385,623,7484,84432,5170,401992,10451,3354,9568,5295,1906,26696,2786,3360,81448,2768,8787,391195,183,9290,10000,2914,2863,2852,7855,7201,165140,1234,6370,5731,5724,29933,2769,9002,80834,440153,4992,3352,431704,3814,403239,10268,6196,5136,401993,57121,5296,109,6754,343171,148,5567,6453,718,2147,391194,1604,10287,7476,983,9630,343173,59345,3576,5540,5533,6093,144124,5528,64857,403257,7433,11255,4887,2832,2492,5997,79541,147,390199,6846,127068,10846,112,254879,89780,81472,5330,5029,339403,23370,256144,6755,7483,347148,391189,84033,10316,7477,8698,5151,3845,1956,54361,2652,10161,121512,117,143496,1812,5999,5745,343406,26693,4923,11211,5137,1606,57105,8527,5732,2532,27237,5364,283694,7409,5518,2781,4157,8620,26245,127062,89846,8503,85397,256933,283869,207,26682,5727,1132,11214,3973,548645,2015,2916,1907,7475,26188,59350,9162,346562,6001,81466,393,9170,8525,9826,1236,8874,2774,2520,1128,504191,64106,5996,8323,1815,5583,134,2793,5580,81061,441933,9181,11251,51764,10381,150,81470,6364,5739,5575,127623,23365,5138,2913,391191,221955,2917,111,6469,4987,594857,401994,7434,3265,94233,3269,2847,50649	MTNR1B,OR2T29,GNB1,CCL17,PRKCA,PDE4C,OR4F3,LPAR3,OR2M7,CDK5,RGS12,GCGR,OXGR1,PIK3CA,HTR6,PPP1CA,CASR,TIAM1,OR2L3,OR6F1,OR1D5,GLP1R,GNG7,OR2T35,PRKAR2B,OR11H2,ABR,WNT8A,SUCNR1,CCR4,ADCY8,RGS11,OPN1MW2,OR6K3,LHB,OR2A42,TAS1R3,GPBAR1,FGD1,P2RY11,OR2A7,GRK5,EDN3,ACKR3,RHOC,DGKQ,VAV2,TRIO,OR2T8,TRH,NTSR2,OR2G6,OR2G3,SLC26A10,RAC2,DRD5,PIK3R5,WNT10A,CCL4,OPN3,OR8U8,GALR1,GNAI2,MTNR1A,OR14C36,CHRM3,GRM2,S1PR3,ADRB2,MAP2K2,GNA11,OR10J5,RHOB,OR10J3,AVPR1B,DAGLA,RGS18,TACR2,ITPR1,TRPC7,TAS2R41,PLCB4,CD97,OR2W5,OR2A1,TACR3,PLA2G4A,RHOG,HBEGF,GPR17,RPS6KA1,XCL1,RAF1,AVPR1A,SCTR,RGS20,OR8D4,HCAR2,LTB4R,PRKACA,GNB2,APP,PDE3A,PLCB3,GLP2R,OR2T12,NMUR2,OR10J1,OR4C13,PDE4D,GPR68,ADCY7,FZD1,ADRA2C,CCL28,OR2V2,S1PR5,ECT2,ADCY1,OR4F16,WNT11,OR2T4,ITPR3,HTR7,PPP2CA,OR14A16,GNAT1,RGS14,OR4C46,OR2M5,HTR2C,FZD8,WNT2,OR2Z1,OR2L13,P2RY1,ADORA2B,PRLH,RGS7,RAMP1,HRH2,RGS17,PLEKHG5,CRHR2,ROCK1P1,MCF2L,ARHGEF1,PPY,CREB1,BDKRB1,WNT9B,PROK1,PDPK1,OR2T2,VAV3,HTR1E,GABBR2,PIK3R1,EDN1,OR2T1,GNG4,HTR4,OR6K2,GNA12,RGS9,OR2T33,AGT,GPR55,AKT3,GRM4,GPR39,GPER1,FZD5,TRHR,OXER1,CCR5,CCL25,PTGER1,PTAFR,GPR132,GNA15,F2RL3,TAS1R2,OR11H12,OR1F1,HTR1D,RGS21,KISS1,OR2T27,RAMP3,RPS6KA2,PDE1A,OR2T5,LPAR5,PIK3R2,ADCY3,SSTR4,OR2W3,ADRA1A,PRKACB,ITSN1,C3,F2,OR2M2,CD55,RGS19,WNT7A,CDK1,GNA14,OR2T3,GNB4,IL8,NPY4R,PPP3CC,ROCK1,OR10A5,PPP2R5D,PLEKHG2,OR4C45,VIPR1,HRH3,NPY2R,NPBWR2,FSHR,RGS2,OR2A4,ADRA1B,OR4D9,XCL2,OR2T34,PDE10A,ADCY6,OR2T6,WNT3A,OR2C3,PLCB2,P2RY2,RXFP4,ARHGEF18,OR4C3,SSTR5,WNT9A,QRFP,OR11L1,OBSCN,NMUR1,WNT7B,S1PR4,PDE8A,KRAS,EGFR,WNT4,OPN1MW,LPAR6,FGD4,ADCYAP1R1,OR52B4,DRD1,RGS4,PTH1R,OR10R2,OR2V1,NTSR1,FZD10,PDE1C,DGKA,CYSLTR2,DGKD,PTGER2,DARC,ARHGEF16,PLXNB1,OR4N4,VAV1,PPP2R1A,GNAZ,MC1R,NPFF,OR2M4,OR2M3,FGD3,PIK3R3,RGS8,NPB,NPW,AKT1,OR4F4,PTCH1,CHRM4,AKAP13,LHCGR,DNAJC25,EMR1,GRM6,EDN2,WNT6,OR1C1,RXFP1,DGKI,GNAT3,RGS10,OR2L5,ARHGAP4,LPAR2,DGKZ,ARHGEF11,CCR7,ARHGEF7,GNAL,GAST,CHRM1,OR9G9,NPFFR1,RGS1,FZD6,DRD4,PRKCH,ADORA1,GNGT2,PRKCD,OR11H1,OR13G1,ARHGEF2,PTGDR2,GNG13,TUBB3,ADRA2A,OR2G2,CCL20,PTGIR,PRKAR1B,OR2B11,ARHGEF12,PDE2A,GRM3,OR2AK2,DAGLB,GRM7,ADCY5,SHH,OPRL1,NPS,OR14I1,VIPR2,HRAS,OPN4,HRH1,MCHR1,ARHGEF4
REACT_19184	GPCR downstream signaling	0.999999999864693	-1.35307348639767e-10	959	299	0.0945305090104331	3163	7167	4544,343563,2782,5578,5143,26683,23566,391196,6002,2642,27199,5290,3362,846,7074,391192,343169,8386,2740,2788,403244,79334,29,56670,1233,114,8786,728458,391114,3972,402317,151306,2245,5032,401427,2869,1908,57007,389,1609,7410,7204,343172,7200,23620,391211,81469,5880,65012,1816,23533,23596,504189,2587,2771,4543,127066,1131,2912,1903,154,2767,127385,388,441911,553,747,64407,6865,3708,57113,259287,5332,441932,346528,6870,391,2840,6375,552,6344,8601,338662,338442,1241,2783,351,5139,5331,9340,127064,56923,26476,283092,5144,8111,113,152,56477,285659,53637,1894,107,81399,127074,3710,3363,284532,2779,10636,119749,127059,3358,284383,284521,5028,136,6000,10267,3274,26575,57449,1395,727758,23263,9138,5539,623,84432,5170,401992,10451,3354,9568,5295,1906,26696,2786,3360,81448,2768,8787,391195,183,9290,10000,2914,2852,7201,165140,1234,6370,5731,5724,29933,2769,9002,440153,4992,3352,431704,3814,403239,10268,5136,401993,57121,5296,109,6754,343171,148,6453,718,2147,391194,10287,9630,343173,59345,3576,5540,6093,144124,64857,403257,7433,11255,4887,2832,2492,5997,79541,147,390199,6846,127068,10846,112,254879,81472,5330,5029,339403,23370,256144,6755,347148,391189,84033,10316,8698,5151,2652,10161,121512,117,143496,1812,5999,5745,343406,26693,4923,1606,57105,8527,5732,27237,5364,283694,7409,2781,4157,8620,26245,127062,89846,8503,85397,256933,283869,207,26682,1132,11214,3973,548645,2916,1907,26188,59350,9162,346562,6001,81466,393,9170,8525,9826,1236,8874,2774,2520,1128,504191,64106,5996,1815,5583,134,2793,5580,81061,441933,9181,11251,51764,10381,150,81470,6364,5739,127623,23365,5138,2913,391191,221955,2917,111,4987,594857,401994,7434,94233,3269,2847,50649	MTNR1B,OR2T29,GNB1,PRKCA,PDE4C,OR4F3,LPAR3,OR2M7,RGS12,GCGR,OXGR1,PIK3CA,HTR6,CASR,TIAM1,OR2L3,OR6F1,OR1D5,GLP1R,GNG7,OR2T35,OR11H2,ABR,SUCNR1,CCR4,ADCY8,RGS11,OPN1MW2,OR6K3,LHB,OR2A42,GPBAR1,FGD1,P2RY11,OR2A7,GRK5,EDN3,ACKR3,RHOC,DGKQ,VAV2,TRIO,OR2T8,TRH,NTSR2,OR2G6,OR2G3,RAC2,SLC26A10,DRD5,PIK3R5,OPN3,OR8U8,GALR1,GNAI2,MTNR1A,OR14C36,CHRM3,GRM2,S1PR3,ADRB2,GNA11,OR10J5,RHOB,OR10J3,AVPR1B,DAGLA,RGS18,TACR2,ITPR1,TRPC7,TAS2R41,PLCB4,OR2W5,OR2A1,TACR3,RHOG,GPR17,XCL1,AVPR1A,SCTR,RGS20,OR8D4,HCAR2,LTB4R,GNB2,APP,PDE3A,PLCB3,GLP2R,OR2T12,NMUR2,OR10J1,OR4C13,PDE4D,GPR68,ADCY7,ADRA2C,CCL28,OR2V2,S1PR5,ECT2,ADCY1,OR4F16,OR2T4,ITPR3,HTR7,OR14A16,GNAT1,RGS14,OR4C46,OR2M5,HTR2C,OR2Z1,OR2L13,P2RY1,ADORA2B,RGS7,RAMP1,HRH2,RGS17,PLEKHG5,CRHR2,ROCK1P1,MCF2L,ARHGEF1,PPY,BDKRB1,PROK1,PDPK1,OR2T2,VAV3,HTR1E,GABBR2,PIK3R1,EDN1,OR2T1,GNG4,HTR4,OR6K2,GNA12,RGS9,OR2T33,AGT,GPR55,AKT3,GRM4,GPER1,TRHR,OXER1,CCR5,CCL25,PTGER1,PTAFR,GPR132,GNA15,F2RL3,OR11H12,OR1F1,HTR1D,RGS21,KISS1,OR2T27,RAMP3,PDE1A,OR2T5,LPAR5,PIK3R2,ADCY3,SSTR4,OR2W3,ADRA1A,ITSN1,C3,F2,OR2M2,RGS19,GNA14,OR2T3,GNB4,IL8,NPY4R,ROCK1,OR10A5,PLEKHG2,OR4C45,VIPR1,HRH3,NPY2R,NPBWR2,FSHR,RGS2,OR2A4,ADRA1B,OR4D9,XCL2,OR2T34,PDE10A,ADCY6,OR2T6,OR2C3,PLCB2,P2RY2,RXFP4,ARHGEF18,OR4C3,SSTR5,QRFP,OR11L1,OBSCN,NMUR1,S1PR4,PDE8A,OPN1MW,LPAR6,FGD4,ADCYAP1R1,OR52B4,DRD1,RGS4,PTH1R,OR10R2,OR2V1,NTSR1,DGKA,CYSLTR2,DGKD,PTGER2,ARHGEF16,PLXNB1,OR4N4,VAV1,GNAZ,MC1R,NPFF,OR2M4,OR2M3,FGD3,PIK3R3,RGS8,NPB,NPW,AKT1,OR4F4,CHRM4,AKAP13,LHCGR,DNAJC25,GRM6,EDN2,OR1C1,RXFP1,DGKI,GNAT3,RGS10,OR2L5,ARHGAP4,LPAR2,DGKZ,ARHGEF11,CCR7,ARHGEF7,GNAL,GAST,CHRM1,OR9G9,NPFFR1,RGS1,DRD4,PRKCH,ADORA1,GNGT2,PRKCD,OR11H1,OR13G1,ARHGEF2,PTGDR2,GNG13,TUBB3,ADRA2A,OR2G2,CCL20,PTGIR,OR2B11,ARHGEF12,PDE2A,GRM3,OR2AK2,DAGLB,GRM7,ADCY5,OPRL1,NPS,OR14I1,VIPR2,OPN4,HRH1,MCHR1,ARHGEF4
REACT_15488	Olfactory Signaling Pathway	0.999999999903386	-9.66144950219565e-11	425	70	0.0221308883970914	3163	7167	343406,343563,26693,2782,338662,26683,440153,283694,4992,391196,127064,403239,26476,401993,127062,26245,283092,343171,391192,343169,391194,285659,8386,26682,81399,403244,127074,79334,343173,284532,26188,391114,402317,144124,81466,119749,403257,401427,127059,284383,2774,284521,343172,504191,391211,81469,79541,390199,127068,81061,441933,254879,504189,81472,127066,256144,401992,81470,391189,26696,127623,441911,127385,391191,81448,391195,441932,346528,401994,143496	OR10R2,OR2T29,OR2V1,GNB1,OR8D4,OR4F3,OR11H12,OR4N4,OR1F1,OR2M7,OR2T12,OR2T27,OR10J1,OR2T5,OR2M3,OR2M4,OR4C13,OR2W3,OR2L3,OR6F1,OR2M2,OR2V2,OR1D5,OR4F4,OR4F16,OR2T35,OR2T4,OR11H2,OR2T3,OR14A16,OR1C1,OR6K3,OR2A42,OR10A5,OR2L5,OR4C46,OR4C45,OR2A7,OR2M5,OR2Z1,GNAL,OR2L13,OR2T8,OR9G9,OR2G6,OR2G3,OR2A4,OR4D9,OR2T34,OR11H1,OR13G1,OR2T6,OR8U8,OR2C3,OR14C36,OR4C3,OR2T2,OR2G2,OR11L1,OR2T1,OR2B11,OR10J3,OR10J5,OR2AK2,OR6K2,OR2T33,OR2W5,OR2A1,OR14I1,OR52B4
REACT_13532	Stimulation of the cell death response by PAK-2p34	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_13528	Regulation of PAK-2p34 activity by PS-GAP/RHG10	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_11050	Transport of connexons to the plasma membrane	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_167	mRNA Editing: C to U Conversion	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_6213	Influenza Virus Induced Apoptosis	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
5709828	Developmental Biology	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_24020	GABA synthesis	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_23964	Degradation of GABA	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_822	Translesion synthesis by Pol zeta	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_1451	PDE3B signalling	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
5710226	Signaling by Robo receptor	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_120823	Synthesis of PS	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_6732	Acetylation	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_6800	Conjugation of phenylacetate with glutamine	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_1390	Formation of the Editosome	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
5710289	Role of Abl in Robo-Slit signaling	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_21343	Activation of Na-permeable Kainate Receptors	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
5709827	Axon guidance	1.00000000000266	2.65851229919178e-12	2	0	0	3163	7167
REACT_1287	Translesion synthesis by Pol eta	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_121079	PI and PC transport between ER and Golgi membranes	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
5417076	Extracellular matrix organization	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_121255	Signaling by FGFR2 amplification mutants	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_22346	Synthesis of dolichyl-phosphate-glucose	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
5416967	Cytokine Signaling in Immune system	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_163938	Acrosome Reaction	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_13721	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
1222499	Response of Mtb to phagocytosis	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_16904	NADPH regeneration	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
5417708	Interleukin-7 signaling	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_526	ABH2 mediated Reversal of Alkylation Damage	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_75880	Tandem pore domain halothane-inhibited K+ channel (THIK)	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_150292	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_11039	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_120920	Synthesis of CL	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_75801	TWIK-related spinal cord K+ channel (TRESK)	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
1222449	Mtb iron assimilation by chelation	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_150253	Synthesis of IPs in the ER lumen	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_11240	BoNT Light Chain Types A, C1, E cleave SNAP-25	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_160194	Biosynthesis of A2E, implicated in retinal degradation	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_160183	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_163796	Interaction With Cumulus Cells	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
5417075	Integrin cell surface interactions	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
5416966	Signaling by Interleukins	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_6350	Inhibition of PKR	1.00000000000317	3.16657811083587e-12	1	0	0	3163	7167
REACT_2108	Beta oxidation of myristoyl-CoA to lauroyl-CoA	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_9398	Oligomerization of connexins into connexons	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_75892	The IPAF inflammasome	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_6341	Mitochondrial Uncoupling Proteins	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_1650	Activation of BIM and translocation to mitochondria	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_25396	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_9392	Transport of connexins along the secretory pathway	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_6258	The fatty acid cycling model	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_850	5-Phosphoribose 1-diphosphate biosynthesis	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_6196	The proton buffering model	1.00000000001186	1.18567655693624e-11	3	0	0	3163	7167
REACT_6933	Conjugation of benzoate with glycine	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_21268	Free fatty acid receptors	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_666	SMAC-mediated apoptotic response	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_1767	SMAC-mediated dissociation of IAP:caspase complexes	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_9037	Plus-strand DNA synthesis	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_6965	Uncoating of the HIV Virion	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_6880	Reverse Transcription of HIV RNA	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_9055	Minus-strand DNA synthesis	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_2190	SMAC binds to IAPs	1.00000000002214	2.21441927295007e-11	5	0	0	3163	7167
REACT_20652	Activation of CaMK IV	1.00000000002371	2.37058775387489e-11	4	0	0	3163	7167
REACT_17003	Alpha-oxidation of phytanate	1.00000000002371	2.37058775387489e-11	4	0	0	3163	7167
REACT_150417	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	1.00000000002571	2.57131629356755e-11	8	0	0	3163	7167
REACT_6889	Conjugation of carboxylic acids	1.00000000002571	2.57131629356755e-11	8	0	0	3163	7167
REACT_6971	Amino Acid conjugation	1.00000000002571	2.57131629356755e-11	8	0	0	3163	7167
REACT_150134	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	1.00000000002629	2.62943129726231e-11	9	0	0	3163	7167
REACT_22151	Transport of nucleotide sugars	1.00000000002629	2.62943129726231e-11	9	0	0	3163	7167
REACT_6812	Conjugation of salicylate with glycine	1.00000000002796	2.7963266251152e-11	7	0	0	3163	7167