TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols SMP00070 Riboflavin Metabolism 0.0283721083647092 -3.56234871622519 5 5 0.0102249488752556 489 995 52,80308,7299,5167,55312 ACP1,FLAD1,TYR,ENPP1,RFK SMP00496 Galactosemia III 0.0310594580506747 -3.4718519098789 8 7 0.0143149284253579 489 995 80146,5236,2584,2645,7360,7358,2582 UXS1,PGM1,GALK1,GCK,UGP2,UGDH,GALE SMP00495 Galactosemia II (GALK) 0.0310594580506747 -3.4718519098789 8 7 0.0143149284253579 489 995 80146,5236,2584,2645,7360,7358,2582 UXS1,PGM1,GALK1,GCK,UGP2,UGDH,GALE SMP00010 Nucleotide Sugars Metabolism 0.0310594580506747 -3.4718519098789 8 7 0.0143149284253579 489 995 80146,5236,2584,2645,7360,7358,2582 UXS1,PGM1,GALK1,GCK,UGP2,UGDH,GALE SMP00358 Fc Epsilon Receptor I Signaling in Mast Cells 0.0435008376888748 -3.1349750838574 41 26 0.0531697341513292 489 995 3562,5321,10451,27040,207,5609,2207,5894,5295,3596,3565,3845,1437,3937,5578,4067,1432,5605,5606,5335,2534,5290,2205,3265,6850,3567 IL3,PLA2G4A,VAV3,LAT,AKT1,MAP2K7,FCER1G,RAF1,PIK3R1,IL13,IL4,KRAS,CSF2,LCP2,PRKCA,LYN,MAPK14,MAP2K2,MAP2K3,PLCG1,FYN,PIK3CA,FCER1A,HRAS,SYK,IL5 SMP00518 Glucose-6-phosphate dehydrogenase deficiency 0.0505029266147786 -2.98572399161213 15 11 0.0224948875255624 489 995 5236,25796,5211,226,7086,51071,2821,6120,6888,22934,5226 PGM1,PGLS,PFKL,ALDOA,TKT,DERA,GPI,RPE,TALDO1,RPIA,PGD SMP00031 Pentose Phosphate Pathway 0.0505029266147786 -2.98572399161213 15 11 0.0224948875255624 489 995 5236,25796,5211,226,7086,51071,2821,6120,6888,22934,5226 PGM1,PGLS,PFKL,ALDOA,TKT,DERA,GPI,RPE,TALDO1,RPIA,PGD SMP00519 Ribose-5-phosphate isomerase deficiency 0.0505029266147786 -2.98572399161213 15 11 0.0224948875255624 489 995 5236,25796,5211,226,7086,51071,2821,6120,6888,22934,5226 PGM1,PGLS,PFKL,ALDOA,TKT,DERA,GPI,RPE,TALDO1,RPIA,PGD SMP00520 Transaldolase deficiency 0.0505029266147786 -2.98572399161213 15 11 0.0224948875255624 489 995 5236,25796,5211,226,7086,51071,2821,6120,6888,22934,5226 PGM1,PGLS,PFKL,ALDOA,TKT,DERA,GPI,RPE,TALDO1,RPIA,PGD SMP00092 Rosuvastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00508 Cholesteryl ester storage disease 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00510 Mevalonic aciduria 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00387 CHILD Syndrome 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00095 Alendronate pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,10654,9453,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,PMVK,GGPS1,FDFT1,HMGCR SMP00107 Zoledronate Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,10654,9453,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,PMVK,GGPS1,FDFT1,HMGCR SMP00389 Smith-Lemli-Opitz Syndrome (SLOS) 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00112 Risedronate Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,10654,9453,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,PMVK,GGPS1,FDFT1,HMGCR SMP00119 Fluvastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00079 Ibandronate Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,10654,9453,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,PMVK,GGPS1,FDFT1,HMGCR SMP00209 Hypercholesterolemia 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00388 Chondrodysplasia Punctata II- X Linked Dominant (CDPX2) 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00386 Desmosterolosis 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00511 Wolman disease 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00023 Steroid Biosynthesis 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00099 Lovastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00509 Hyper-IgD syndrome 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00131 Atorvastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00082 Simvastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00117 Pamidronate Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,10654,9453,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,PMVK,GGPS1,FDFT1,HMGCR SMP00319 Lysosomal Acid Lipase Deficiency (Wolman Disease) 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00089 Pravastatin Pathway 0.0550880391957314 -2.89882266087498 22 15 0.0306748466257669 489 995 6646,4047,3157,3422,4598,6307,2224,6713,7108,51478,3988,9453,10654,2222,3156 SOAT1,LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SQLE,TM7SF2,HSD17B7,LIPA,GGPS1,PMVK,FDFT1,HMGCR SMP00076 Thiamine Metabolism 0.0579726997719983 -2.84778307283295 4 4 0.0081799591002045 489 995 84284,79178,10560,27010 NTPCR,THTPA,SLC19A2,TPK1 SMP00467 Trehalose Degradation 0.063928547869961 -2.74998925883718 12 9 0.0184049079754601 489 995 476,2645,486,480,11181,481,6523,477,478 ATP1A1,GCK,FXYD2,ATP1A4,TREH,ATP1B1,SLC5A1,ATP1A2,ATP1A3 SMP00368 Labetalol Pathway 0.0695458414765025 -2.66576915425503 59 35 0.0715746421267894 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,148,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ADRA1A,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00367 Carvedilol Pathway 0.0695458414765025 -2.66576915425503 59 35 0.0715746421267894 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,148,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ADRA1A,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00306 Pindolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00323 Quinidine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,481,3752,3784,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,ATP1B1,KCND3,KCNQ1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00379 Nifedipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00325 Disopyramide Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,481,3752,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,ATP1B1,KCND3,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00380 Nimodipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00381 Nisoldipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00324 Procainamide (Antiarrhythmic) Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,481,3752,3784,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,ATP1B1,KCND3,KCNQ1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00366 Nebivolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00377 Felodipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00296 Acebutolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00305 Penbutolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00327 Phenytoin (Antiarrhythmic) Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00588 Muscle/Heart Contraction 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00298 Atenolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00304 Oxprenolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00332 Ibutilide Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00378 Isradipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00303 Nadolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00297 Alprenolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00331 Flecainide Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00359 Diltiazem Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00375 Verapamil Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00382 Nitrendipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00329 Mexiletine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00302 Metoprolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00300 Bisoprolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00376 Amlodipine Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00299 Betaxolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00330 Tocainide Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00307 Propranolol Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,6641,3757,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,SNTB1,KCNH2,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway 0.0880439655444883 -2.42991898080659 58 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 0.102685212807737 -2.27608715675968 38 23 0.0470347648261759 489 995 5058,5170,5609,207,9693,6195,8874,2782,136,5605,3725,4792,3551,4790,5590,5290,5600,10411,1385,4791,1386,3265,5567 PAK1,PDPK1,MAP2K7,AKT1,RAPGEF2,RPS6KA1,ARHGEF7,GNB1,ADORA2B,MAP2K2,JUN,NFKBIA,IKBKB,NFKB1,PRKCZ,PIK3CA,MAPK11,RAPGEF3,CREB1,NFKB2,ATF2,HRAS,PRKACB SMP00459 Pyruvaldehyde Degradation 0.118331107353467 -2.13426858944922 3 3 0.00613496932515337 489 995 2739,3029,197257 GLO1,HAGH,LDHD SMP00128 Gluconeogenesis 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00581 Glycogenosis- Type IA. Von gierke disease 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00574 Glycogenosis- Type IC 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00563 Triosephosphate isomerase 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00562 Fructose-1-6-diphosphatase deficiency 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00560 Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1) 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00573 Glycogenosis- Type IB 0.123022933791342 -2.09538448740188 22 14 0.0286298568507157 489 995 5236,2597,5091,2542,669,226,53354,3099,5105,8402,5224,2821,2023,51660 PGM1,GAPDH,PC,SLC37A4,BPGM,ALDOA,PANK1,HK2,PCK1,SLC25A11,PGAM2,GPI,ENO1,MPC1 SMP00328 Lidocaine (Antiarrhythmic) Pathway 0.142538332323127 -1.94814431668833 60 34 0.0695296523517382 489 995 7140,7134,8912,9254,7135,10021,5566,6833,1739,30819,477,144245,3753,7125,7136,7169,3759,480,6262,3784,3752,481,3757,6641,3762,476,5350,486,3775,4638,7139,3767,7168,478 TNNT3,TNNC1,CACNA1H,CACNA2D2,TNNI1,HCN4,PRKACA,ABCC8,DLG1,KCNIP2,ATP1A2,ALG10B,KCNE1,TNNC2,TNNI2,TPM2,KCNJ2,ATP1A4,RYR2,KCNQ1,KCND3,ATP1B1,KCNH2,SNTB1,KCNJ5,ATP1A1,PLN,FXYD2,KCNK1,MYLK,TNNT2,KCNJ11,TPM1,ATP1A3 SMP00078 Chlorothiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00088 Bumetanide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00115 Furosemide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00197 Lysinuric Protein Intolerance 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00105 Metolazone Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00245 Glucose Transporter Defect (SGLT2) 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00090 Bendroflumethiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00100 Hydrochlorothiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00583 Blue diaper syndrome 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00135 Eplerenone Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,4306,477,23428,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,NR3C2,ATP1A2,SLC7A8,SLC22A6,ATP1A3 SMP00483 Kidney Function 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00081 Methyclothiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00108 Hydroflumethiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00134 Spironolactone Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,4306,477,23428,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,NR3C2,ATP1A2,SLC7A8,SLC22A6,ATP1A3 SMP00118 Torsemide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00189 Hartnup Disorder 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00584 Iminoglycinuria 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00133 Amiloride Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00184 Renal Glucosuria 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00097 Ethacrynic Acid pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00091 Quinethazone Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,6339,11136,8140,6338,4306,477,23428,478,9356 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SCNN1D,SLC7A9,SLC7A5,SCNN1B,NR3C2,ATP1A2,SLC7A8,ATP1A3,SLC22A6 SMP00585 Lysinuric protein intolerance (LPI) 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00132 Triamterene Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00103 Cyclothiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00110 Indapamide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00193 Iminoglycinuria 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00121 Trichlormethiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00080 Polythiazide Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00122 Chlorthalidone Pathway 0.159447741840265 -1.8360390478072 32 19 0.0388548057259714 489 995 6582,6559,480,358,360,481,9057,6337,476,486,11136,6339,8140,6338,23428,477,4306,9356,478 SLC22A2,SLC12A3,ATP1A4,AQP1,AQP3,ATP1B1,SLC7A6,SCNN1A,ATP1A1,FXYD2,SLC7A9,SCNN1D,SLC7A5,SCNN1B,SLC7A8,ATP1A2,NR3C2,SLC22A6,ATP1A3 SMP00320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 0.175051759130625 -1.74267358232819 38 22 0.0449897750511247 489 995 5058,5170,207,5609,9693,6195,8874,2782,5605,3725,4792,3551,4790,5590,5290,5600,10411,4791,1385,1386,3265,5567 PAK1,PDPK1,AKT1,MAP2K7,RAPGEF2,RPS6KA1,ARHGEF7,GNB1,MAP2K2,JUN,NFKBIA,IKBKB,NFKB1,PRKCZ,PIK3CA,MAPK11,RAPGEF3,NFKB2,CREB1,ATF2,HRAS,PRKACB SMP00055 Alanine Metabolism 0.176375065401001 -1.7351424980027 5 4 0.0081799591002045 489 995 189,5091,2875,57505 AGXT,PC,GPT,AARS2 SMP00352 Primary Hyperoxaluria Type I 0.176375065401001 -1.7351424980027 5 4 0.0081799591002045 489 995 189,5091,2875,57505 AGXT,PC,GPT,AARS2 SMP00350 Pyruvate Carboxylase Deficiency 0.176375065401001 -1.7351424980027 5 4 0.0081799591002045 489 995 189,5091,2875,57505 AGXT,PC,GPT,AARS2 SMP00313 Lactic Acidemia 0.176375065401001 -1.7351424980027 5 4 0.0081799591002045 489 995 189,5091,2875,57505 AGXT,PC,GPT,AARS2 SMP00455 Homocysteine Degradation 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 875,1491 CBS,CTH SMP00612 Esomeprazole Pathway 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 495,496 ATP4A,ATP4B SMP00616 Rabeprazole Pathway 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 495,496 ATP4A,ATP4B SMP00613 Omeprazole Pathway 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 495,496 ATP4A,ATP4B SMP00515 Homocystinuria- cystathionine beta-synthase deficiency 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 875,1491 CBS,CTH SMP00614 Lansoprazole Pathway 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 495,496 ATP4A,ATP4B SMP00615 Pantoprazole Pathway 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 495,496 ATP4A,ATP4B SMP00514 Gamma-cystathionase deficiency (CTH) 0.2412788287517 -1.42180204848592 2 2 0.00408997955010225 489 995 875,1491 CBS,CTH SMP00228 Pantoprazole Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00232 Cimetidine Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00225 Esomeprazole Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00230 Ranitidine Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00226 Omeprazole Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00029 Selenoamino Acid Metabolism 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 27430,875,2678,191,9061,51540,1491 MAT2B,CBS,GGT1,AHCY,PAPSS1,SCLY,CTH SMP00589 Gastric Acid Production 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00229 Rabeprazole Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00233 Nizatidine Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00458 Lactose Intolerance 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 476,481,486,6523,477,480,478 ATP1A1,ATP1B1,FXYD2,SLC5A1,ATP1A2,ATP1A4,ATP1A3 SMP00227 Lansoprazole Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00231 Famotidine Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00246 Pirenzepine Pathway 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 495,6754,496,1193,1131,3274,2520 ATP4A,SSTR4,ATP4B,CLIC2,CHRM3,HRH2,GAST SMP00457 Lactose Degradation 0.254281983667606 -1.36931145582903 11 7 0.0143149284253579 489 995 476,481,486,6523,477,480,478 ATP1A1,ATP1B1,FXYD2,SLC5A1,ATP1A2,ATP1A4,ATP1A3 SMP00203 Molybdenium Cofactor Deficiency 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00167 Adenylosuccinate Lyase Deficiency 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00365 Gout or Kelley-Seegmiller Syndrome 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00537 Myoadenylate deaminase deficiency 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00050 Purine Metabolism 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00144 Adenosine Deaminase Deficiency 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00536 Mitochondrial DNA depletion syndrome 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00535 Adenine phosphoribosyltransferase deficiency (APRT) 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00512 Xanthinuria type I 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00513 Xanthinuria type II 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00210 Purine Nucleoside Phosphorylase Deficiency 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00364 Lesch-Nyhan Syndrome (LNS) 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00168 AICA-Ribosiduria 0.269773108074605 -1.31017401373217 36 20 0.0408997955010225 489 995 2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,55811,1716 GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,ADCY10,DGUOK SMP00040 Glycolysis 0.27903838643563 -1.27640592083404 15 9 0.0184049079754601 489 995 2597,669,5313,226,53354,3099,5224,2821,2023 GAPDH,BPGM,PKLR,ALDOA,PANK1,HK2,PGAM2,GPI,ENO1 SMP00531 Glycogenosis- Type VII. Tarui disease 0.27903838643563 -1.27640592083404 15 9 0.0184049079754601 489 995 2597,669,5313,226,53354,3099,5224,2821,2023 GAPDH,BPGM,PKLR,ALDOA,PANK1,HK2,PGAM2,GPI,ENO1 SMP00572 Fanconi-bickel syndrome 0.27903838643563 -1.27640592083404 15 9 0.0184049079754601 489 995 2597,669,5313,226,53354,3099,5224,2821,2023 GAPDH,BPGM,PKLR,ALDOA,PANK1,HK2,PGAM2,GPI,ENO1 SMP00442 Etoposide Pathway 0.287973149173927 -1.24488803522754 17 10 0.0204498977505112 489 995 5743,5479,64714,3309,5742,23753,10961,4353,10130,9601 PTGS2,PPIB,PDIA2,HSPA5,PTGS1,SDF2L1,ERP29,MPO,PDIA6,PDIA4 SMP00601 Etoposide Pathway 0.287973149173927 -1.24488803522754 17 10 0.0204498977505112 489 995 5743,5479,64714,3309,5742,23753,10961,4353,10130,9601 PTGS2,PPIB,PDIA2,HSPA5,PTGS1,SDF2L1,ERP29,MPO,PDIA6,PDIA4 SMP00153 Quinapril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00165 Valsartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00150 Lisinopril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00164 Telmisartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00145 Benazepril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00152 Perindopril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00163 Olmesartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00154 Ramipril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00148 Enalapril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00162 Losartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00155 Rescinnamine Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00161 Irbesartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00146 Captopril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00160 Forasartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00587 Angiotensin metabolism 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00159 Eprosartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00147 Cilazapril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00151 Moexipril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00158 Candesartan Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00157 Trandolapril Pathway 0.299406330097835 -1.20595366460877 4 3 0.00613496932515337 489 995 183,1636,5972 AGT,ACE,REN SMP00582 Joubert syndrome 0.301654232802848 -1.1984738420279 21 12 0.0245398773006135 489 995 56623,5295,8821,5290,2064,10423,8394,8867,5305,1956,5286,55697 INPP5E,PIK3R1,INPP4B,PIK3CA,ERBB2,CDIPT,PIP5K1A,SYNJ1,PIP4K2A,EGFR,PIK3C2A,VAC14 SMP00463 Phosphatidylinositol Phosphate Metabolism 0.301654232802848 -1.1984738420279 21 12 0.0245398773006135 489 995 56623,5295,8821,5290,2064,10423,8394,8867,5305,1956,5286,55697 INPP5E,PIK3R1,INPP4B,PIK3CA,ERBB2,CDIPT,PIP5K1A,SYNJ1,PIP4K2A,EGFR,PIK3C2A,VAC14 SMP00004 Glycine and Serine Metabolism 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00484 Dimethylglycinuria 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00244 Sarcosinemia 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00242 Dimethylglycine Dehydrogenase Deficiency 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00223 Non Ketotic Hyperglycinemia 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00485 Hyperglycinemia- non-ketotic 0.311609813256341 -1.16600347236096 25 14 0.0286298568507157 489 995 1757,189,6470,29968,10993,23464,2593,4128,875,275,5723,132158,2731,1491 SARDH,AGXT,SHMT1,PSAT1,SDS,GCAT,GAMT,MAOA,CBS,AMT,PSPH,GLYCTK,GLDC,CTH SMP00445 Spermidine and Spermine Biosynthesis 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 27430,6723,4953,262 MAT2B,SRM,ODC1,AMD1 SMP00454 Repaglinide Pathway 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 6833,3630,773,9254 ABCC8,INS,CACNA1A,CACNA2D2 SMP00453 Nateglinide Pathway 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 6833,3630,773,9254 ABCC8,INS,CACNA1A,CACNA2D2 SMP00460 Glibenclamide Pathway 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 6833,3630,773,9254 ABCC8,INS,CACNA1A,CACNA2D2 SMP00643 Pancreas Function 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 6833,3630,773,9254 ABCC8,INS,CACNA1A,CACNA2D2 SMP00461 Gliclazide Pathway 0.327367981169134 -1.11667041611183 6 4 0.0081799591002045 489 995 6833,3630,773,9254 ABCC8,INS,CACNA1A,CACNA2D2 SMP00335 Intracellular Signalling Through Histamine H2 Receptor and Histamine 0.344151427590893 -1.06667352198163 8 5 0.0102249488752556 489 995 2782,5499,1385,5567,3274 GNB1,PPP1CA,CREB1,PRKACB,HRH2 SMP00354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 0.344151427590893 -1.06667352198163 8 5 0.0102249488752556 489 995 2782,5739,4638,5567,4634 GNB1,PTGIR,MYLK,PRKACB,MYL3 SMP00309 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 0.344151427590893 -1.06667352198163 8 5 0.0102249488752556 489 995 2782,5499,1385,3360,5567 GNB1,PPP1CA,CREB1,HTR4,PRKACB SMP00311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 0.344151427590893 -1.06667352198163 8 5 0.0102249488752556 489 995 2782,5499,1385,3360,5567 GNB1,PPP1CA,CREB1,HTR4,PRKACB SMP00338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin 0.355412371098848 -1.03447655492298 10 6 0.0122699386503067 489 995 2782,5499,3973,1385,3972,5567 GNB1,PPP1CA,LHCGR,CREB1,LHB,PRKACB SMP00187 Glycerol Kinase Deficiency 0.363490469120248 -1.01200220210403 12 7 0.0143149284253579 489 995 57678,3990,132158,218,8612,2819,1606 GPAM,LIPC,GLYCTK,ALDH3A1,PPAP2C,GPD1,DGKA SMP00530 Familial lipoprotein lipase deficiency 0.363490469120248 -1.01200220210403 12 7 0.0143149284253579 489 995 57678,3990,132158,218,8612,2819,1606 GPAM,LIPC,GLYCTK,ALDH3A1,PPAP2C,GPD1,DGKA SMP00529 D-glyceric acidura 0.363490469120248 -1.01200220210403 12 7 0.0143149284253579 489 995 57678,3990,132158,218,8612,2819,1606 GPAM,LIPC,GLYCTK,ALDH3A1,PPAP2C,GPD1,DGKA SMP00039 Glycerolipid Metabolism 0.363490469120248 -1.01200220210403 12 7 0.0143149284253579 489 995 57678,3990,132158,218,8612,2819,1606 GPAM,LIPC,GLYCTK,ALDH3A1,PPAP2C,GPD1,DGKA SMP00048 Nicotinate and Nicotinamide Metabolism 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 5167,55191,4837,4860,23057,83594,65220,10135 ENPP1,NADSYN1,NNMT,PNP,NMNAT2,NUDT12,NADK,NAMPT SMP00043 Galactose Metabolism 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 2683,5236,2584,2548,3098,2645,7360,2582 B4GALT1,PGM1,GALK1,GAA,HK1,GCK,UGP2,GALE SMP00067 Aspartate Metabolism 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 790,440,4677,1615,435,445,339983,122622 CAD,ASNS,NARS,DARS,ASL,ASS1,NAT8L,ADSSL1 SMP00175 Canavan Disease 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 790,440,4677,1615,435,445,339983,122622 CAD,ASNS,NARS,DARS,ASL,ASS1,NAT8L,ADSSL1 SMP00182 Galactosemia 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 2683,5236,2584,2548,3098,2645,7360,2582 B4GALT1,PGM1,GALK1,GAA,HK1,GCK,UGP2,GALE SMP00192 Hypoacetylaspartia 0.369547121698793 -0.995477018446724 14 8 0.016359918200409 489 995 790,440,4677,1615,435,445,339983,122622 CAD,ASNS,NARS,DARS,ASL,ASS1,NAT8L,ADSSL1 SMP00561 Fructosuria 0.37793520263085 -0.973032519668421 18 10 0.0204498977505112 489 995 5372,197258,7264,5211,226,29925,3098,2762,3795,29085 PMM1,FUK,TSTA3,PFKL,ALDOA,GMPPB,HK1,GMDS,KHK,PHPT1 SMP00064 Fructose and Mannose Degradation 0.37793520263085 -0.973032519668421 18 10 0.0204498977505112 489 995 5372,197258,7264,5211,226,29925,3098,2762,3795,29085 PMM1,FUK,TSTA3,PFKL,ALDOA,GMPPB,HK1,GMDS,KHK,PHPT1 SMP00650 Doxorubicin Pathway 0.383338938641975 -0.958835723855577 22 12 0.0245398773006135 489 995 847,873,6647,1728,10928,85413,1244,4843,2876,4720,5447,374291 CAT,CBR1,SOD1,NQO1,RALBP1,SLC22A16,ABCC2,NOS2,GPX1,NDUFS2,POR,NDUFS7 SMP00423 Desipramine Pathway 0.389480314725236 -0.942941954806703 30 16 0.032719836400818 489 995 1565,6531,480,773,2902,9254,1141,481,476,1137,486,30819,148,477,478,1812 CYP2D6,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,CHRNA4,FXYD2,KCNIP2,ADRA1A,ATP1A2,ATP1A3,DRD1 SMP00411 Hydrocodone Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00417 Sufentanil Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00404 Ropivacaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00425 Escitalopram Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00392 Benzocaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00410 Hydromorphone Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00399 Mepivacaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00416 Remifentanil Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00393 Bupivacaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00396 Dibucaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00415 Fentanyl Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00401 Prilocaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00400 Oxybuprocaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00394 Chloroprocaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00414 Carfentanil Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00397 Levobupivacaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00413 Alfentanil Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00395 Cocaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,480,773,6531,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,ATP1A4,CACNA1A,SLC6A3,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00412 Oxymorphone Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00403 Proparacaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00402 Procaine Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00409 Oxycodone Pathway 0.462496380589696 -0.771116547812287 29 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00506 Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00507 L-arginine:glycine amidinotransferase deficiency 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00505 Hyperornithinemia with gyrate atrophy (HOGA) 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00362 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00504 Creatine deficiency- guanidinoacetate methyltransferase deficiency 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00207 Prolidase Deficiency (PD) 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00360 Hyperprolinemia Type II 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00208 Prolinemia Type II 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00361 Hyperprolinemia Type I 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00020 Arginine and Proline Metabolism 0.471270833091056 -0.752322333046285 17 9 0.0184049079754601 489 995 8659,2058,5625,2593,435,445,1152,29920,4942 ALDH4A1,EPRS,PRODH,GAMT,ASL,ASS1,CKB,PYCR2,OAT SMP00044 Histidine Metabolism 0.472985676285962 -0.74869017364226 15 8 0.016359918200409 489 995 4128,84735,57571,23438,10841,131669,10196,218 MAOA,CNDP1,CARNS1,HARS2,FTCD,UROC1,PRMT3,ALDH3A1 SMP00191 Histidinemia 0.472985676285962 -0.74869017364226 15 8 0.016359918200409 489 995 4128,84735,57571,23438,10841,131669,10196,218 MAOA,CNDP1,CARNS1,HARS2,FTCD,UROC1,PRMT3,ALDH3A1 SMP00603 Gemcitabine Pathway 0.474809800172371 -0.744840975827013 13 7 0.0143149284253579 489 995 6241,1635,30833,50484,1633,1503,9154 RRM2,DCTD,NT5C,RRM2B,DCK,CTPS1,SLC28A1 SMP00446 Gemcitabine Pathway 0.474809800172371 -0.744840975827013 13 7 0.0143149284253579 489 995 6241,1635,30833,50484,1633,1503,9154 RRM2,DCTD,NT5C,RRM2B,DCK,CTPS1,SLC28A1 SMP00566 17-alpha-hydroxylase deficiency (CYP17) 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00575 11-beta-hydroxylase deficiency (CYP11B1) 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00576 21-hydroxylase deficiency (CYP21) 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00577 Corticosterone methyl oxidase I deficiency (CMO I) 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00578 Corticosterone methyl oxidase II deficiency - CMO II 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 2782,5499,1385,3360,5567 GNB1,PPP1CA,CREB1,HTR4,PRKACB SMP00466 Transfer of Acetyl Groups into Mitochondria 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 8402,5091,51660,47,6576 SLC25A11,PC,MPC1,ACLY,SLC25A1 SMP00373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00130 Steroidogenesis 0.478900096246621 -0.736263270659234 9 5 0.0102249488752556 489 995 1584,1583,1589,3290,1585 CYP11B1,CYP11A1,CYP21A2,HSD11B1,CYP11B2 SMP00449 Ethanol Degradation 0.481261670849421 -0.731344142558516 7 4 0.0081799591002045 489 995 847,219,84532,55902 CAT,ALDH1B1,ACSS1,ACSS2 SMP00041 Sulfate/Sulfite Metabolism 0.481261670849421 -0.731344142558516 7 4 0.0081799591002045 489 995 10380,50515,6821,6820 BPNT1,CHST11,SUOX,SULT2B1 SMP00532 Sulfite oxidase deficiency 0.481261670849421 -0.731344142558516 7 4 0.0081799591002045 489 995 10380,50515,6821,6820 BPNT1,CHST11,SUOX,SULT2B1 SMP00123 Betaine Metabolism 0.481261670849421 -0.731344142558516 7 4 0.0081799591002045 489 995 191,501,10400,4548 AHCY,ALDH7A1,PEMT,MTR SMP00468 Degradation of Superoxides 0.483953227148007 -0.725767015059221 5 3 0.00613496932515337 489 995 847,6647,7306 CAT,SOD1,TYRP1 SMP00018 Alpha Linolenic Acid and Linoleic Acid Metabolism 0.483953227148007 -0.725767015059221 5 3 0.00613496932515337 489 995 60481,9415,6785 ELOVL5,FADS2,ELOVL4 SMP00503 Hypophosphatasia 0.483953227148007 -0.725767015059221 5 3 0.00613496932515337 489 995 55163,57026,8566 PNPO,PDXP,PDXK SMP00017 Vitamin B6 Metabolism 0.483953227148007 -0.725767015059221 5 3 0.00613496932515337 489 995 55163,57026,8566 PNPO,PDXP,PDXK SMP00420 Bevacizumab Pathway 0.487174271546621 -0.719133372793238 3 2 0.00408997955010225 489 995 7422,2321 VEGFA,FLT1 SMP00124 Glycerol Phosphate Shuttle 0.487174271546621 -0.719133372793238 3 2 0.00408997955010225 489 995 2597,2819 GAPDH,GPD1 SMP00456 Fatty Acid Biosynthesis 0.487174271546621 -0.719133372793238 3 2 0.00408997955010225 489 995 55301,2194 OLAH,FASN SMP00476 Trastuzumab Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1956 EGFR SMP00593 Enalapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00473 Gefitinib Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1956 EGFR SMP00632 Prednisolone Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 2908 NR3C1 SMP00595 Moexipril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00475 Panitumumab Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1956 EGFR SMP00474 Cetuximab Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1956 EGFR SMP00591 Benazepril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00597 Ramipril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00596 Quinapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00617 Cimetidine Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 3274 HRH2 SMP00592 Cilazapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00036 D-Arginine and D-Ornithine Metabolism 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1610 DAO SMP00149 Fosinopril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00599 Trandolapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00263 Cilostazol Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 5144 PDE4D SMP00594 Fosinopril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00598 Spirapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00156 Spirapril Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1636 ACE SMP00264 Dipyridamole (Antiplatelet) Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 5144 PDE4D SMP00441 Prednisolone Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 2908 NR3C1 SMP00472 Erlotinib Pathway 0.491457286432449 -0.710380247683133 1 1 0.00204498977505112 489 995 1956 EGFR SMP00428 Mercaptopurine Pathway 0.512557109781777 -0.668343140457308 46 23 0.0470347648261759 489 995 10257,2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,9153,55811,132,1716 ABCC4,GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,SLC28A2,ADCY10,ADK,DGUOK SMP00430 Thioguanine Pathway 0.512557109781777 -0.668343140457308 46 23 0.0470347648261759 489 995 10257,2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,9153,55811,132,1716 ABCC4,GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,SLC28A2,ADCY10,ADK,DGUOK SMP00406 Morphine Pathway 0.514920578775718 -0.663742606180387 44 22 0.0449897750511247 489 995 5479,6531,3309,773,480,2902,9254,1141,481,23753,10961,9601,64714,476,1137,486,30819,10130,477,148,1812,478 PPIB,SLC6A3,HSPA5,CACNA1A,ATP1A4,GRIN1,CACNA2D2,CHRNB2,ATP1B1,SDF2L1,ERP29,PDIA4,PDIA2,ATP1A1,CHRNA4,FXYD2,KCNIP2,PDIA6,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00405 Codeine Pathway 0.531995802118813 -0.631119680425735 32 16 0.032719836400818 489 995 1565,773,480,6531,2902,9254,1141,481,476,486,1137,30819,148,477,1812,478 CYP2D6,CACNA1A,ATP1A4,SLC6A3,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,KCNIP2,ADRA1A,ATP1A2,DRD1,ATP1A3 SMP00407 Heroin Pathway 0.531995802118813 -0.631119680425735 32 16 0.032719836400818 489 995 773,480,6531,1066,2902,9254,1141,481,476,486,1137,30819,148,477,1812,478 CACNA1A,ATP1A4,SLC6A3,CES1,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,KCNIP2,ADRA1A,ATP1A2,DRD1,ATP1A3 SMP00649 Lamivudine Pathway 0.564606463553002 -0.571626315206665 18 9 0.0184049079754601 489 995 6582,6581,10257,5230,1633,30833,1244,8714,56994 SLC22A2,SLC22A3,ABCC4,PGK1,DCK,NT5C,ABCC2,ABCC3,CHPT1 SMP00555 Glycogenosis- Type VI. Hers disease 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 2632,5236,2821,2645,7360,7358,3099,6476 GBE1,PGM1,GPI,GCK,UGP2,UGDH,HK2,SI SMP00058 Starch and Sucrose Metabolism 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 2632,5236,2821,2645,7360,7358,3099,6476 GBE1,PGM1,GPI,GCK,UGP2,UGDH,HK2,SI SMP00557 Sucrase-isomaltase deficiency 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 2632,5236,2821,2645,7360,7358,3099,6476 GBE1,PGM1,GPI,GCK,UGP2,UGDH,HK2,SI SMP00390 Tay-Sachs Disease 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00045 Amino Sugar Metabolism 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00240 Salla Disease/Infantile Sialic Acid Storage Disease 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00534 G(M2)-Gangliosidosis: Variant B- Tay-sachs disease 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00556 Mucopolysaccharidosis VI. Sly syndrome 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 2632,5236,2821,2645,7360,7358,3099,6476 GBE1,PGM1,GPI,GCK,UGP2,UGDH,HK2,SI SMP00216 Sialuria or French Type Sialuria 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00552 Glycogen synthetase deficiency 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 2632,5236,2821,2645,7360,7358,3099,6476 GBE1,PGM1,GPI,GCK,UGP2,UGDH,HK2,SI SMP00217 Sjogren Larsson Syndrome 0.571740469792214 -0.559070114705769 16 8 0.016359918200409 489 995 55907,6675,10007,5973,80896,3098,1118,140838 CMAS,UAP1,GNPDA1,RENBP,NPL,HK1,CHIT1,NANP SMP00345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3145,210,7390,5498,3162,1352,94033 HMBS,ALAD,UROS,PPOX,HMOX1,COX10,FTMT SMP00344 Acute Intermittent Porphyria 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3145,210,7390,5498,3162,1352,94033 HMBS,ALAD,UROS,PPOX,HMOX1,COX10,FTMT SMP00024 Porphyrin Metabolism 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3145,210,7390,5498,3162,1352,94033 HMBS,ALAD,UROS,PPOX,HMOX1,COX10,FTMT SMP00342 Hereditary Coproporphyria (HCP) 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3145,210,7390,5498,3162,1352,94033 HMBS,ALAD,UROS,PPOX,HMOX1,COX10,FTMT SMP00462 Inositol Phosphate Metabolism 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3612,64768,51477,3631,9807,11165,8821 IMPA1,IPPK,ISYNA1,INPP4A,IP6K1,NUDT3,INPP4B SMP00346 Porphyria Variegata (PV) 0.580072478648055 -0.544602220062618 14 7 0.0143149284253579 489 995 3145,210,7390,5498,3162,1352,94033 HMBS,ALAD,UROS,PPOX,HMOX1,COX10,FTMT SMP00543 Homocystinuria due to defect of N(5-10)-methylene THF deficiency 0.590047202915656 -0.527552740340806 12 6 0.0122699386503067 489 995 6573,10841,10797,25902,10588,2356 SLC19A1,FTCD,MTHFD2,MTHFD1L,MTHFS,FPGS SMP00432 Methotrexate Pathway 0.590047202915656 -0.527552740340806 12 6 0.0122699386503067 489 995 6573,10841,10797,25902,10588,2356 SLC19A1,FTCD,MTHFD2,MTHFD1L,MTHFS,FPGS SMP00053 Folate Metabolism 0.590047202915656 -0.527552740340806 12 6 0.0122699386503067 489 995 6573,10841,10797,25902,10588,2356 SLC19A1,FTCD,MTHFD2,MTHFD1L,MTHFS,FPGS SMP00424 Citalopram Pathway 0.594797053932419 -0.519535017447376 35 17 0.0347648261758691 489 995 1565,773,480,6531,2902,9254,1141,481,476,486,1137,4128,30819,148,477,478,1812 CYP2D6,CACNA1A,ATP1A4,SLC6A3,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,MAOA,KCNIP2,ADRA1A,ATP1A2,ATP1A3,DRD1 SMP00422 Imipramine Pathway 0.599793738097266 -0.511169452706277 33 16 0.032719836400818 489 995 1565,773,480,6531,2902,9254,1141,481,476,486,1137,30819,148,477,478,1812 CYP2D6,CACNA1A,ATP1A4,SLC6A3,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,KCNIP2,ADRA1A,ATP1A2,ATP1A3,DRD1 SMP00436 Vinblastine Pathway 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 8714,1244,1026,10928,10376 ABCC3,ABCC2,CDKN1A,RALBP1,TUBA1B SMP00015 Glutathione Metabolism 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00500 5-oxoprolinase deficiency 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00516 Adrenoleukodystrophy- X-linked 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 5194,215,2180,5195,1384 PEX13,ABCD1,ACSL1,PEX14,CRAT SMP00333 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2782,5499,1385,2492,5567 GNB1,PPP1CA,CREB1,FSHR,PRKACB SMP00439 Vinorelbine Pathway 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 8714,1244,1026,10928,10376 ABCC3,ABCC2,CDKN1A,RALBP1,TUBA1B SMP00052 Beta Oxidation of Very Long Chain Fatty Acids 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 5194,215,2180,5195,1384 PEX13,ABCD1,ACSL1,PEX14,CRAT SMP00337 Glutathione Synthetase Deficiency 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00143 5-Oxoprolinuria 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00501 Gamma-glutamyl-transpeptidase deficiency 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00437 Vincristine Pathway 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 8714,1244,1026,10928,10376 ABCC3,ABCC2,CDKN1A,RALBP1,TUBA1B SMP00438 Vindesine Pathway 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 8714,1244,1026,10928,10376 ABCC3,ABCC2,CDKN1A,RALBP1,TUBA1B SMP00517 Carnitine-acylcarnitine translocase deficiency 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 5194,215,2180,5195,1384 PEX13,ABCD1,ACSL1,PEX14,CRAT SMP00183 Gamma-Glutamyltransferase Deficiency 0.602387821396694 -0.506853819505772 10 5 0.0102249488752556 489 995 2678,26873,79017,2876,290 GGT1,OPLAH,GGCT,GPX1,ANPEP SMP00398 Lidocaine (Local Anaesthetic) Pathway 0.60517090825551 -0.502244367860612 31 15 0.0306748466257669 489 995 476,486,1137,6531,480,773,2902,9254,1141,481,30819,477,148,1812,478 ATP1A1,FXYD2,CHRNA4,SLC6A3,ATP1A4,CACNA1A,GRIN1,CACNA2D2,CHRNB2,ATP1B1,KCNIP2,ATP1A2,ADRA1A,DRD1,ATP1A3 SMP00025 Phospholipid Biosynthesis 0.617318580288685 -0.482370050750174 27 13 0.0265848670756646 489 995 8611,10400,9489,1103,1606,5338,57678,10423,56994,43,23761,1040,2819 PPAP2A,PEMT,PGS1,CHAT,DGKA,PLD2,GPAM,CDIPT,CHPT1,ACHE,PISD,CDS1,GPD1 SMP00127 Glucose-Alanine Cycle 0.618371914110522 -0.480665199767278 8 4 0.0081799591002045 489 995 84706,79751,2875,6509 GPT2,SLC25A22,GPT,SLC1A4 SMP00640 Acetaminophen Pathway 0.624255007429183 -0.471196328341918 25 12 0.0245398773006135 489 995 5479,64714,1565,1548,3309,54578,23753,10961,2950,10130,6818,9601 PPIB,PDIA2,CYP2D6,CYP2A6,HSPA5,UGT1A6,SDF2L1,ERP29,GSTP1,PDIA6,SULT1A3,PDIA4 SMP00355 Mitochondrial Electron Transport Chain 0.640452290558443 -0.445580648228535 21 10 0.0204498977505112 489 995 6390,2597,2542,291,517,6391,54205,498,514,2819 SDHB,GAPDH,SLC37A4,SLC25A4,ATP5G2,SDHC,CYCS,ATP5A1,ATP5E,GPD1 SMP00308 Dopamine Activation of Neurological Reward System 0.640538473130052 -0.445446092111221 6 3 0.00613496932515337 489 995 2782,5567,1812 GNB1,PRKACB,DRD1 SMP00027 Pantothenate and CoA Biosynthesis 0.640538473130052 -0.445446092111221 6 3 0.00613496932515337 489 995 5167,53354,60490 ENPP1,PANK1,PPCDC SMP00063 Tryptophan Metabolism 0.650070184137521 -0.430674946325214 19 9 0.0184049079754601 489 995 847,10352,8564,8942,130013,23498,15,125061,1644 CAT,WARS2,KMO,KYNU,ACMSD,HAAO,AANAT,AFMID,DDC SMP00431 Nicotine Pathway 0.656677211972463 -0.42056268720584 36 17 0.0347648261758691 489 995 6531,773,480,2902,9254,1141,481,476,486,1137,1548,30819,148,477,2328,478,1812 SLC6A3,CACNA1A,ATP1A4,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,CYP2A6,KCNIP2,ADRA1A,ATP1A2,FMO3,ATP1A3,DRD1 SMP00426 Fluoxetine Pathway 0.662975494441791 -0.411017251105631 34 16 0.032719836400818 489 995 1565,773,480,6531,2902,9254,1141,481,476,486,1137,30819,148,477,478,1812 CYP2D6,CACNA1A,ATP1A4,SLC6A3,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,KCNIP2,ADRA1A,ATP1A2,ATP1A3,DRD1 SMP00429 Disulfiram Pathway 0.669737178377229 -0.400869914634314 32 15 0.0306748466257669 489 995 847,53905,2954,55902,23498,1103,218,4128,7299,2805,50506,7173,219,84532,1644 CAT,DUOX1,GSTZ1,ACSS2,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,ALDH1B1,ACSS1,DDC SMP00469 Capecitabine Pathway 0.674942213002353 -0.393128202141269 4 2 0.00408997955010225 489 995 1890,1066 TYMP,CES1 SMP00433 Irinotecan Pathway 0.674942213002353 -0.393128202141269 4 2 0.00408997955010225 489 995 1066,7150 CES1,TOP1 SMP00600 Irinotecan Pathway 0.674942213002353 -0.393128202141269 4 2 0.00408997955010225 489 995 1066,7150 CES1,TOP1 SMP00607 Capecitabine Pathway 0.674942213002353 -0.393128202141269 4 2 0.00408997955010225 489 995 1890,1066 TYMP,CES1 SMP00427 Azathioprine Pathway 0.678056694730002 -0.38852437399202 49 23 0.0470347648261759 489 995 10257,2987,4860,5471,6241,377841,353,318,100,159,2618,957,10606,471,10846,2983,3614,8833,5144,9153,55811,132,1716 ABCC4,GUK1,PNP,PPAT,RRM2,ENTPD8,APRT,NUDT2,ADA,ADSS,GART,ENTPD5,PAICS,ATIC,PDE10A,GUCY1B3,IMPDH1,GMPS,PDE4D,SLC28A2,ADCY10,ADK,DGUOK SMP00102 Bromfenac Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00098 Ketorolac Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00106 Meloxicam Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00085 Ketoprofen Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00353 Leukotriene C4 Synthesis Deficiency 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00094 Sulindac Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00114 Nabumetone Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00109 Mefanamic Acid Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00113 Oxaprozin Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00289 Diflunisal Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00077 Piroxicam Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00083 Acetylsalicylic Acid Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00084 Etodolac Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00075 Arachidonic Acid Metabolism 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00093 Diclofenac Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00101 Suprofen Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00087 Rofecoxib Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00116 Valdecoxib Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00120 Naproxen Pathway 0.684932610945416 -0.378434823741237 28 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00590 Ibuprofen Pathway 0.713445585580055 -0.337649109051907 22 10 0.0204498977505112 489 995 5743,5479,64714,7363,3309,5742,23753,10961,10130,9601 PTGS2,PPIB,PDIA2,UGT2B4,HSPA5,PTGS1,SDF2L1,ERP29,PDIA6,PDIA4 SMP00408 Methadone Pathway 0.720388918029303 -0.32796404887847 35 16 0.032719836400818 489 995 1565,6531,773,480,2902,9254,1141,481,476,486,1137,30819,148,477,478,1812 CYP2D6,SLC6A3,CACNA1A,ATP1A4,GRIN1,CACNA2D2,CHRNB2,ATP1B1,ATP1A1,FXYD2,CHRNA4,KCNIP2,ADRA1A,ATP1A2,ATP1A3,DRD1 SMP00499 Beta-mercaptolactate-cysteine disulfiduria 0.729949368404392 -0.314780105595249 9 4 0.0081799591002045 489 995 833,2805,1497,1491 CARS,GOT1,CTNS,CTH SMP00013 Cysteine Metabolism 0.729949368404392 -0.314780105595249 9 4 0.0081799591002045 489 995 833,2805,1497,1491 CARS,GOT1,CTNS,CTH SMP00452 Threonine and 2-Oxobutanoate Degradation 0.729949368404392 -0.314780105595249 9 4 0.0081799591002045 489 995 5096,4594,10993,594 PCCB,MUT,SDS,BCKDHB SMP00628 Nicotine Pathway 0.729949368404392 -0.314780105595249 9 4 0.0081799591002045 489 995 1137,1548,2328,1141 CHRNA4,CYP2A6,FMO3,CHRNB2 SMP00464 Vitamin K Metabolism 0.741635744105605 -0.298897067259856 2 1 0.00204498977505112 489 995 1728 NQO1 SMP00104 Indomethacin Pathway 0.745012606644467 -0.294354139075322 29 13 0.0265848670756646 489 995 240,2678,5743,127281,873,4056,5740,5730,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,LTC4S,PTGIS,PTGDS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00622 Morphine Pathway 0.753132400325135 -0.283514236193537 16 7 0.0143149284253579 489 995 5479,64714,23753,10130,10961,3309,9601 PPIB,PDIA2,SDF2L1,PDIA6,ERP29,HSPA5,PDIA4 SMP00648 Sorafenib Pathway 0.753132400325135 -0.283514236193537 16 7 0.0143149284253579 489 995 5479,64714,23753,10130,10961,3309,9601 PPIB,PDIA2,SDF2L1,PDIA6,ERP29,HSPA5,PDIA4 SMP00218 Tyrosinemia Type I 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00498 Dopamine beta-hydroxylase deficiency 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00533 Monoamine oxidase-a deficiency (MAO-A) 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00190 Hawkinsinuria 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00006 Tyrosine Metabolism 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00169 Alkaptonuria 0.764870026261374 -0.268049359902223 25 11 0.0224948875255624 489 995 53905,2954,23498,1103,218,4128,7299,2805,50506,7173,1644 DUOX1,GSTZ1,HAAO,CHAT,ALDH3A1,MAOA,TYR,GOT1,DUOX2,TPO,DDC SMP00198 Malonic Aciduria 0.770384350238017 -0.260865732518131 14 6 0.0122699386503067 489 995 23417,5096,26275,4594,4329,84532 MLYCD,PCCB,HIBCH,MUT,ALDH6A1,ACSS1 SMP00201 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 0.770384350238017 -0.260865732518131 14 6 0.0122699386503067 489 995 23417,5096,26275,4594,4329,84532 MLYCD,PCCB,HIBCH,MUT,ALDH6A1,ACSS1 SMP00502 Malonyl-coa decarboxylase deficiency 0.770384350238017 -0.260865732518131 14 6 0.0122699386503067 489 995 23417,5096,26275,4594,4329,84532 MLYCD,PCCB,HIBCH,MUT,ALDH6A1,ACSS1 SMP00016 Propanoate Metabolism 0.770384350238017 -0.260865732518131 14 6 0.0122699386503067 489 995 23417,5096,26275,4594,4329,84532 MLYCD,PCCB,HIBCH,MUT,ALDH6A1,ACSS1 SMP00219 UMP Synthase Deiciency (Orotic Aciduria) 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 790,1890,50484,54963,1807,1503,1723,6241,1635,50808 CAD,TYMP,RRM2B,UCKL1,DPYS,CTPS1,DHODH,RRM2,DCTD,AK3 SMP00202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 790,1890,50484,54963,1807,1503,1723,6241,1635,50808 CAD,TYMP,RRM2B,UCKL1,DPYS,CTPS1,DHODH,RRM2,DCTD,AK3 SMP00172 Beta Ureidopropionase Deficiency 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 790,1890,50484,54963,1807,1503,1723,6241,1635,50808 CAD,TYMP,RRM2B,UCKL1,DPYS,CTPS1,DHODH,RRM2,DCTD,AK3 SMP00525 Fabry disease 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00046 Pyrimidine Metabolism 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 790,1890,50484,54963,1807,1503,1723,6241,1635,50808 CAD,TYMP,RRM2B,UCKL1,DPYS,CTPS1,DHODH,RRM2,DCTD,AK3 SMP00526 Krabbe disease 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00349 Gaucher Disease 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00034 Sphingolipid Metabolism 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00178 Dihydropyrimidinase Deficiency 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 790,1890,50484,54963,1807,1503,1723,6241,1635,50808 CAD,TYMP,RRM2B,UCKL1,DPYS,CTPS1,DHODH,RRM2,DCTD,AK3 SMP00347 Metachromatic Leukodystrophy (MLD) 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00348 Globoid Cell Leukodystrophy 0.77616130463362 -0.253394913604325 23 10 0.0204498977505112 489 995 2531,8611,2581,2629,64781,123099,56848,9517,130367,410 KDSR,PPAP2A,GALC,GBA,CERK,DEGS2,SPHK2,SPTLC2,SGPP2,ARSA SMP00086 Ibuprofen Pathway 0.781091742244179 -0.247062668379036 47 21 0.0429447852760736 489 995 2678,127281,5479,7363,3309,6916,23753,10961,9601,240,5743,64714,873,4056,5740,5730,5742,4048,10130,2876,9536 GGT1,FAM213B,PPIB,UGT2B4,HSPA5,TBXAS1,SDF2L1,ERP29,PDIA4,ALOX5,PTGS2,PDIA2,CBR1,LTC4S,PTGIS,PTGDS,PTGS1,LTA4H,PDIA6,GPX1,PTGES SMP00060 Pyruvate Metabolism 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00196 Leigh Syndrome 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00212 Pyruvate Dehydrogenase Complex Deficiency 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00558 Primary hyperoxaluria II- PH2 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00559 Pyruvate kinase deficiency 0.788567851705439 -0.23753682465738 21 9 0.0184049079754601 489 995 9380,5091,55902,5313,5105,2739,4200,3029,197257 GRHPR,PC,ACSS2,PKLR,PCK1,GLO1,ME2,HAGH,LDHD SMP00030 Oxidation of Branched Chain Fatty Acids 0.79065824228576 -0.234889462371315 12 5 0.0102249488752556 489 995 5194,215,2180,5195,1384 PEX13,ABCD1,ACSL1,PEX14,CRAT SMP00479 Plasmalogen Synthesis 0.802268203575802 -0.220312308597306 5 2 0.00408997955010225 489 995 8611,8443 PPAP2A,GNPAT SMP00465 Carnitine Synthesis 0.802268203575802 -0.220312308597306 5 2 0.00408997955010225 489 995 6470,80854 SHMT1,SETD7 SMP00340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00221 Methionine Adenosyltransferase Deficiency 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00177 Cystathionine Beta-Synthase Deficiency 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00341 Hypermethioninemia 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00033 Methionine Metabolism 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00222 Glycine N-methyltransferase Deficiency 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00570 Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism- cblG complementation type 0.80229284578612 -0.220281593392884 19 8 0.016359918200409 489 995 27430,875,6723,191,6470,4548,262,1491 MAT2B,CBS,SRM,AHCY,SHMT1,MTR,AMD1,CTH SMP00609 Mercaptopurine Pathway 0.834791629920592 -0.180573130278096 15 6 0.0122699386503067 489 995 3614,8833,9153,10257,132,5471 IMPDH1,GMPS,SLC28A2,ABCC4,ADK,PPAT SMP00009 Ammonia Recycling 0.844970571283982 -0.168453479114295 8 3 0.00613496932515337 489 995 440,10993,2752 ASNS,SDS,GLUL SMP00644 Celecoxib Pathway 0.844970571283982 -0.168453479114295 8 3 0.00613496932515337 489 995 5743,5742,1565 PTGS2,PTGS1,CYP2D6 SMP00037 Lysine Degradation 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00186 Glutaric Aciduria Type III 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00528 Hyperlysinemia II or Saccharopinuria 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00527 Hyperlysinemia I- Familial 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00239 Saccharopinuria/Hyperlysinemia II 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00571 Pyridoxine dependency with seizures 0.854305818995138 -0.157466047428894 13 5 0.0102249488752556 489 995 501,4967,3033,2639,1743 ALDH7A1,OGDH,HADH,GCDH,DLST SMP00602 Teniposide Pathway 0.868866480394417 -0.14056581293896 3 1 0.00204498977505112 489 995 4353 MPO SMP00619 Felodipine Pathway 0.868866480394417 -0.14056581293896 3 1 0.00204498977505112 489 995 9254 CACNA2D2 SMP00635 Valproic Acid Pathway 0.868866480394417 -0.14056581293896 3 1 0.00204498977505112 489 995 1548 CYP2A6 SMP00443 Teniposide Pathway 0.868866480394417 -0.14056581293896 3 1 0.00204498977505112 489 995 4353 MPO SMP00626 Desipramine Pathway 0.868866480394417 -0.14056581293896 3 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00096 Celecoxib Pathway 0.868883580746422 -0.140546131913032 34 14 0.0286298568507157 489 995 240,2678,5743,127281,873,1565,4056,5730,5740,6916,5742,4048,2876,9536 ALOX5,GGT1,PTGS2,FAM213B,CBR1,CYP2D6,LTC4S,PTGDS,PTGIS,TBXAS1,PTGS1,LTA4H,GPX1,PTGES SMP00434 Paclitaxel Pathway 0.883133068801824 -0.124279388937583 6 2 0.00408997955010225 489 995 1244,10376 ABCC2,TUBA1B SMP00322 Vasopressin Regulation of Water Homeostasis 0.883133068801824 -0.124279388937583 6 2 0.00408997955010225 489 995 2782,5567 GNB1,PRKACB SMP00343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 0.883133068801824 -0.124279388937583 6 2 0.00408997955010225 489 995 2782,5567 GNB1,PRKACB SMP00435 Docetaxel Pathway 0.883133068801824 -0.124279388937583 6 2 0.00408997955010225 489 995 1244,10376 ABCC2,TUBA1B SMP00275 Ardeparin Pathway 0.893880787073886 -0.112182860492304 21 8 0.016359918200409 489 995 2165,2147,2159,1277,2162,462,2155,2153 F13B,F2,F10,COL1A1,F13A1,SERPINC1,F7,F5 SMP00273 Fondaparinux Pathway 0.893880787073886 -0.112182860492304 21 8 0.016359918200409 489 995 2165,2147,2159,1277,2162,462,2155,2153 F13B,F2,F10,COL1A1,F13A1,SERPINC1,F7,F5 SMP00274 Heparin Pathway 0.893880787073886 -0.112182860492304 21 8 0.016359918200409 489 995 2165,2147,2159,1277,2162,462,2155,2153 F13B,F2,F10,COL1A1,F13A1,SERPINC1,F7,F5 SMP00272 Enoxaparin Pathway 0.893880787073886 -0.112182860492304 21 8 0.016359918200409 489 995 2165,2147,2159,1277,2162,462,2155,2153 F13B,F2,F10,COL1A1,F13A1,SERPINC1,F7,F5 SMP00136 2-Hydroxyglutric Aciduria (D And L Form) 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00567 Succinic semialdehyde dehydrogenase deficiency 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00339 Hyperinsulinism-Hyperammonemia Syndrome 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00243 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00351 GABA-Transaminase Deficiency 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 84735,4329,1807 CNDP1,ALDH6A1,DPYS SMP00492 Ureidopropionase deficiency 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 84735,4329,1807 CNDP1,ALDH6A1,DPYS SMP00385 Homocarnosinosis 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00493 Carnosinuria- carnosinemia 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 84735,4329,1807 CNDP1,ALDH6A1,DPYS SMP00072 Glutamate Metabolism 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 8659,79944,2752 ALDH4A1,L2HGDH,GLUL SMP00007 Beta-Alanine Metabolism 0.902481172726671 -0.102607450237385 9 3 0.00613496932515337 489 995 84735,4329,1807 CNDP1,ALDH6A1,DPYS SMP00011 Inositol Metabolism 0.919893453098457 -0.0834974274952638 17 6 0.0122699386503067 489 995 3612,113026,51477,3631,55586,5290 IMPA1,PLCD3,ISYNA1,INPP4A,MIOX,PIK3CA SMP00627 Citalopram Pathway 0.932387866387302 -0.0700063852178407 7 2 0.00408997955010225 489 995 4128,1565 MAOA,CYP2D6 SMP00480 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 0.932387866387302 -0.0700063852178407 7 2 0.00408997955010225 489 995 35,3033 ACADS,HADH SMP00568 Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (SCHAD) 0.932387866387302 -0.0700063852178407 7 2 0.00408997955010225 489 995 35,3033 ACADS,HADH SMP00310 Corticotropin Activation of Cortisol Production 0.932387866387302 -0.0700063852178407 7 2 0.00408997955010225 489 995 2782,5567 GNB1,PRKACB SMP00418 Adefovir Dipivoxil Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 204 AK2 SMP00623 Heroin Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1066 CES1 SMP00618 Fosphenytoin (Antiarrhythmic) Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 6641 SNTB1 SMP00633 Felbamate Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 218 ALDH3A1 SMP00419 Tenofovir Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 204 AK2 SMP00170 Aromatic L-Aminoacid Decarboxylase Deficiency 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1644 DDC SMP00621 Codeine Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00450 Phytanic Acid Peroxisomal Oxidation 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 224 ALDH3A2 SMP00012 Catecholamine Biosynthesis 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1644 DDC SMP00065 Ubiquinone Biosynthesis 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 10229 COQ7 SMP00629 Adefovir Dipivoxil Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 204 AK2 SMP00497 Tyrosine hydroxylase deficiency 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1644 DDC SMP00451 Refsum Disease 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 224 ALDH3A2 SMP00639 Clomipramine Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00129 Malate-Aspartate Shuttle 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 8402 SLC25A11 SMP00630 Tenofovir Pathway 0.933507902867243 -0.0688058501901928 4 1 0.00204498977505112 489 995 204 AK2 SMP00282 Streptokinase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,2153,1277,2162 F13B,F2,F10,F7,F5,COL1A1,F13A1 SMP00276 Argatroban Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00288 Aprotinin Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00548 Mitochondrial complex II deficiency 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00279 Ximelagatran Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00281 Anistreplase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00057 Citric Acid Cycle 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00283 Tenecteplase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00269 Acenocoumarol Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00280 Alteplase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00277 Bivalirudin Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00271 Phenprocoumon Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00285 Reteplase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00551 Pyruvate dehydrogenase deficiency (E2) 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00278 Lepirudin Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00586 Coagulation 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00284 Urokinase Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00287 Tranexamic Acid Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00546 Congenital lactic acidosis 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00270 Dicumarol Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00286 Aminocaproic Acid Pathway 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 2165,2147,2159,2155,1277,2153,2162 F13B,F2,F10,F7,COL1A1,F5,F13A1 SMP00549 2-ketoglutarate dehydrogenase complex deficiency 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00547 Fumarase deficiency 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00550 Pyruvate dehydrogenase deficiency (E3) 0.934915584256641 -0.0672990379868117 20 7 0.0143149284253579 489 995 6390,4967,5091,1743,6391,51660,2271 SDHB,OGDH,PC,DLST,SDHC,MPC1,FH SMP00580 GLUT-1 deficiency syndrome 0.939977218292832 -0.0618996398704698 10 3 0.00613496932515337 489 995 2683,7360,6513 B4GALT1,UGP2,SLC2A1 SMP00444 Lactose Synthesis 0.939977218292832 -0.0618996398704698 10 3 0.00613496932515337 489 995 2683,7360,6513 B4GALT1,UGP2,SLC2A1 SMP00606 Tamoxifen Pathway 0.939977218292832 -0.0618996398704698 10 3 0.00613496932515337 489 995 1565,2326,2328 CYP2D6,FMO1,FMO3 SMP00471 Tamoxifen Pathway 0.939977218292832 -0.0618996398704698 10 3 0.00613496932515337 489 995 1565,2326,2328 CYP2D6,FMO1,FMO3 SMP00579 Congenital disorder of glycosylation CDG-IId 0.939977218292832 -0.0618996398704698 10 3 0.00613496932515337 489 995 2683,7360,6513 B4GALT1,UGP2,SLC2A1 SMP00002 Carbamoyl Phosphate Synthetase Deficiency 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00003 Argininosuccinic Aciduria 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00357 Argininemia 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00001 Citrullinemia Type I 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00059 Urea Cycle 0.948705455101634 -0.0526569025190596 13 4 0.0081799591002045 489 995 445,2875,6509,435 ASS1,GPT,SLC1A4,ASL SMP00487 Hyperphenylalaniemia due to guanosine triphosphate cyclohydrolase deficiency 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00005 Pterine Biosynthesis 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00488 Hyperphenylalaninemia due to 6-pyruvoyltetrahydropterin synthase deficiency (ptps) 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00605 Ifosfamide Pathway 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 1548,218 CYP2A6,ALDH3A1 SMP00073 Butyrate Metabolism 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 35,3033 ACADS,HADH SMP00448 Ifosfamide Pathway 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 1548,218 CYP2A6,ALDH3A1 SMP00490 Segawa syndrome 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00491 Sepiapterin reductase deficiency 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00486 Dopa-responsive dystonia 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00489 Hyperphenylalaninemia due to dhpr-deficiency 0.961526964757965 -0.0392326698764788 8 2 0.00408997955010225 489 995 5805,873 PTS,CBR1 SMP00336 Vitamin A Deficiency 0.961916774571359 -0.0388273449784745 36 13 0.0265848670756646 489 995 54884,5479,64714,1548,3309,23753,8694,9249,10961,10130,9227,1592,9601 RETSAT,PPIB,PDIA2,CYP2A6,HSPA5,SDF2L1,DGAT1,DHRS3,ERP29,PDIA6,LRAT,CYP26A1,PDIA4 SMP00074 Retinol Metabolism 0.961916774571359 -0.0388273449784745 36 13 0.0265848670756646 489 995 54884,5479,64714,1548,3309,23753,8694,9249,10961,10130,9227,1592,9601 RETSAT,PPIB,PDIA2,CYP2A6,HSPA5,SDF2L1,DGAT1,DHRS3,ERP29,PDIA6,LRAT,CYP26A1,PDIA4 SMP00370 Tyrosinemia Type 3 (TYRO3) 0.963721541563464 -0.0369528833982083 11 3 0.00613496932515337 489 995 2954,2805,10056 GSTZ1,GOT1,FARSB SMP00008 Phenylalanine and Tyrosine Metabolism 0.963721541563464 -0.0369528833982083 11 3 0.00613496932515337 489 995 2954,2805,10056 GSTZ1,GOT1,FARSB SMP00206 Phenylketonuria 0.963721541563464 -0.0369528833982083 11 3 0.00613496932515337 489 995 2954,2805,10056 GSTZ1,GOT1,FARSB SMP00369 Tyrosinemia Type 2 (or Richner-Hanhart syndrome) 0.963721541563464 -0.0369528833982083 11 3 0.00613496932515337 489 995 2954,2805,10056 GSTZ1,GOT1,FARSB SMP00021 Taurine and Hypotaurine Metabolism 0.966317827695528 -0.0342624847053496 5 1 0.00204498977505112 489 995 51380 CSAD SMP00641 Doxepin Pathway 0.966317827695528 -0.0342624847053496 5 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00637 Tramadol Pathway 0.966317827695528 -0.0342624847053496 5 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00569 Succinyl CoA: 3-ketoacid CoA transferase deficiency 0.966317827695528 -0.0342624847053496 5 1 0.00204498977505112 489 995 622 BDH1 SMP00071 Ketone Body Metabolism 0.966317827695528 -0.0342624847053496 5 1 0.00204498977505112 489 995 622 BDH1 SMP00185 Glutaric Aciduria Type I 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00540 Very-long-chain acyl coa dehydrogenase deficiency (VLCAD) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00545 Trifunctional protein deficiency 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00542 Medium chain acyl-coa dehydrogenase deficiency (MCAD) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00235 Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00181 Ethylmalonic Encephalopathy 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00538 Carnitine palmitoyl transferase deficiency (I) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00541 Carnitine palmitoyl transferase deficiency (II) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00051 Fatty acid Metabolism 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00539 Long chain acyl-CoA dehydrogenase deficiency (LCAD) 0.967816094266581 -0.0327131950168423 14 4 0.0081799591002045 489 995 35,2180,2639,37 ACADS,ACSL1,GCDH,ACADVL SMP00642 Nevirapine Pathway 0.978397191055438 -0.0218395655705344 9 2 0.00408997955010225 489 995 1565,7015 CYP2D6,TERT SMP00068 Androgen and Estrogen Metabolism 0.978408917679312 -0.0218275800970405 12 3 0.00613496932515337 489 995 3292,1588,6820 HSD17B1,CYP19A1,SULT2B1 SMP00565 Aromatase deficiency 0.978408917679312 -0.0218275800970405 12 3 0.00613496932515337 489 995 3292,1588,6820 HSD17B1,CYP19A1,SULT2B1 SMP00356 17-Beta Hydroxysteroid Dehydrogenase III Deficiency 0.978408917679312 -0.0218275800970405 12 3 0.00613496932515337 489 995 3292,1588,6820 HSD17B1,CYP19A1,SULT2B1 SMP00646 Fluoxetine Pathway 0.9829547794784 -0.0171921624583295 6 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00636 Venlafaxine Pathway 0.9829547794784 -0.0171921624583295 6 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00625 Imipramine Pathway 0.9829547794784 -0.0171921624583295 6 1 0.00204498977505112 489 995 1565 CYP2D6 SMP00482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 0.988002184248825 -0.01207037045855 10 2 0.00408997955010225 489 995 2180,3033 ACSL1,HADH SMP00624 Methadone Pathway 0.988002184248825 -0.01207037045855 10 2 0.00408997955010225 489 995 1565,2902 CYP2D6,GRIN1 SMP00522 3-hydroxyisobutyric aciduria 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00524 Isovaleric acidemia 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00523 Isobutyryl-coa dehydrogenase deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00237 3-Methylcrotonyl Coa Carboxylase Deficiency Type I 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00238 Isovaleric Aciduria 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00199 Maple Syrup Urine Disease 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00521 3-hydroxyisobutyric acid dehydrogenase deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00236 Propionic Acidemia 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00200 Methylmalonic Aciduria 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00140 3-Methylglutaconic Aciduria Type III 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00139 3-Methylglutaconic Aciduria Type I 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00032 Valine- Leucine and Isoleucine Degradation 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00173 Beta-Ketothiolase Deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00141 3-Methylglutaconic Aciduria Type IV 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00137 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00138 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency 0.990567495091873 -0.00947727272002042 30 9 0.0184049079754601 489 995 35,5096,4594,4329,594,56922,26275,64087,11112 ACADS,PCCB,MUT,ALDH6A1,BCKDHB,MCCC1,HIBCH,MCCC2,HIBADH SMP00634 Carbamazepine Pathway 0.991382598329084 -0.00865474617319077 7 1 0.00204498977505112 489 995 2052 EPHX1 SMP00317 Familial Hypercholanemia (FHCA) 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00316 Zellweger Syndrome 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00315 Cerebrotendinous Xanthomatosis (CTX) 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00314 Congenital Bile Acid Synthesis Defect Type II 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00035 Bile Acid Biosynthesis 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00318 Congenital Bile Acid Synthesis Defect Type III 0.992700322560414 -0.00732645045409299 17 4 0.0081799591002045 489 995 3295,3988,10858,80270 HSD17B4,LIPA,CYP46A1,HSD3B7 SMP00604 Cyclophosphamide Pathway 0.993397882624598 -0.0066240077540835 11 2 0.00408997955010225 489 995 1548,218 CYP2A6,ALDH3A1 SMP00447 Cyclophosphamide Pathway 0.993397882624598 -0.0066240077540835 11 2 0.00408997955010225 489 995 1548,218 CYP2A6,ALDH3A1 SMP00481 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 0.995647688842302 -0.00436181003530519 8 1 0.00204498977505112 489 995 3033 HADH SMP00028 Caffeine Metabolism 0.995647688842302 -0.00436181003530519 8 1 0.00204498977505112 489 995 1548 CYP2A6 SMP00652 Mycophenolic Acid Pathway 0.998640026405619 -0.00136089919776271 17 3 0.00613496932515337 489 995 3614,1244,1066 IMPDH1,ABCC2,CES1 SMP00265 Abciximab Pathway 0.99999999999322 -6.78035405599076e-12 2 0 0 489 995 SMP00267 Tirofiban Pathway 0.99999999999322 -6.78035405599076e-12 2 0 0 489 995 SMP00266 Eptifibatide Pathway 0.99999999999322 -6.78035405599076e-12 2 0 0 489 995 SMP00653 Rosiglitazone Pathway 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00126 Phenylacetate Metabolism 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00564 Multiple carboxylase deficiency- neonatal or early onset form 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00645 Azathioprine Pathway 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00174 Biotinidase Deficiency 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00066 Biotin Metabolism 0.999999999998782 -1.21849752510172e-12 3 0 0 489 995 SMP00631 Prednisone Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00268 Warfarin Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00261 Ticlopidine Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00647 Thioguanine Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00391 Insulin Signalling 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00421 Vatalanib Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00611 Ticlopidine Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00470 Fluorouracil Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00301 Esmolol Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00440 Prednisone Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00638 Levomethadyl Acetate Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00608 Fluorouracil Pathway 1.00000000000052 5.16031661845773e-13 1 0 0 489 995 SMP00651 Artemether Pathway 1.00000000000542 5.41694467059983e-12 4 0 0 489 995 SMP00620 Lidocaine (Local Anaesthetic) Pathway 1.00000000000542 5.41694467059983e-12 4 0 0 489 995 SMP00054 Fatty Acid Elongation In Mitochondria 1.000000000015 1.50009822272312e-11 7 0 0 489 995 SMP00544 Long-chain-3-hydroxyacyl-coa dehydrogenase deficiency (LCHAD) 1.000000000015 1.50009822272312e-11 7 0 0 489 995 SMP00610 Clopidogrel Pathway 1.00000000002017 2.01741334141664e-11 9 0 0 489 995 SMP00260 Clopidogrel Pathway 1.00000000002017 2.01741334141664e-11 9 0 0 489 995