TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
WP1982	SREBP signalling	0.000150364240914535	-8.80244993459466	64	45	0.0210970464135021	2133	4508	6396,51141,2475,133522,3949,693120,5566,10483,23175,3422,3157,56681,5290,6720,1385,3837,6667,51360,2222,3156,10802,207,2931,267,2194,820,3630,22872,51128,4047,4800,3638,22937,2224,51586,1622,47,6713,22926,949,57678,7528,84532,8720,11236	SEC13,INSIG2,MTOR,PPARGC1B,LDLR,MIR33B,PRKACA,SEC23B,LPIN1,IDI1,HMGCS1,SAR1A,PIK3CA,SREBF1,CREB1,KPNB1,SP1,MBTPS2,FDFT1,HMGCR,SEC24A,AKT1,GSK3A,AMFR,FASN,CAMP,INS,SEC31A,SAR1B,LSS,NFYA,INSIG1,SCAP,FDPS,MED15,DBI,ACLY,SQLE,ATF6,SCARB1,GPAM,YY1,ACSS1,MBTPS1,RNF139
WP363	Wnt Signaling Pathway NetPath	0.000301508349727737	-8.1067128482245	115	73	0.0342240975152368	2133	4508	5894,51701,324,1488,5578,23002,595,999,1499,5300,2516,1739,815,1856,8321,207,1454,7476,995,57216,983,4088,5515,644172,817,8607,6299,28996,8312,85407,6500,2932,1855,4089,1453,51588,860,3728,6908,100500905,8325,6662,5076,7472,6929,1452,8323,3725,56998,1601,5601,7020,29117,6422,89780,6885,283106,7484,818,7483,607,2274,2011,9479,59343,22943,54361,816,408,1740,7855,1487,8945	RAF1,NLK,APC,CTBP2,PRKCA,DAAM1,CCND1,CDH1,CTNNB1,PIN1,NR5A1,DLG1,CAMK2A,DVL2,FZD1,AKT1,CSNK1E,WNT7A,CDC25C,VANGL2,CDK1,SMAD3,PPP2CA,LOC644172,CAMK2D,RUVBL1,SALL1,HIPK2,AXIN1,NKD1,SKP1,GSK3B,DVL1,SMAD4,CSNK1D,PIAS4,RUNX2,JUP,TBP,MIR3661,FZD8,SOX9,PAX2,WNT2,TCF3,CSNK1A1,FZD6,JUN,CTNNBIP1,DAB2,MAPK9,TFAP2A,BRD7,SFRP1,WNT3A,MAP3K7,CSNK2A3,WNT9B,CAMK2G,WNT9A,BCL9,FHL2,MARK2,MAPK8IP1,SENP2,DKK1,WNT4,CAMK2B,ARRB1,DLG2,FZD5,CTBP1,BTRC
WP127	IL-5 Signaling Pathway	0.000354941856565939	-7.94355656622427	69	47	0.0220346929207689	2133	4508	5321,5894,6195,4067,1432,3383,25759,240,1399,7409,3725,9094,6464,8651,1499,896,5580,5296,4790,5601,5781,1785,3717,6386,5292,6774,1386,6850,2889,2931,207,5777,5295,3845,3560,867,5605,3689,10603,4792,2932,2185,6776,7534,5909,3265,3567	PLA2G4A,RAF1,RPS6KA1,LYN,MAPK14,ICAM1,SHC2,ALOX5,CRKL,VAV1,JUN,UNC119,SHC1,SOCS1,CTNNB1,CCND3,PRKCD,PIK3R2,NFKB1,MAPK9,PTPN11,DNM2,JAK2,SDCBP,PIM1,STAT3,ATF2,SYK,RAPGEF1,GSK3A,AKT1,PTPN6,PIK3R1,KRAS,IL2RB,CBL,MAP2K2,ITGB2,SH2B2,NFKBIA,GSK3B,PTK2B,STAT5A,YWHAZ,RAP1GAP,HRAS,IL5
WP2018	RANKL/RANK Signaling Pathway	0.0012627243657351	-6.67448369717053	54	37	0.0173464603844351	2133	4508	7189,2475,7186,4067,1432,6714,3383,3725,8878,3551,4286,4790,5296,5601,5971,4791,6885,6688,6850,8792,207,5609,5295,2274,5747,867,1513,2353,4772,8517,5335,7185,23118,4792,7187,4982,7188	TRAF6,MTOR,TRAF2,LYN,MAPK14,SRC,ICAM1,JUN,SQSTM1,IKBKB,MITF,NFKB1,PIK3R2,MAPK9,RELB,NFKB2,MAP3K7,SPI1,SYK,TNFRSF11A,AKT1,MAP2K7,PIK3R1,FHL2,PTK2,CBL,CTSK,FOS,NFATC1,IKBKG,PLCG1,TRAF1,TAB2,NFKBIA,TRAF3,TNFRSF11B,TRAF5
WP585	Interferon type I	0.00140629840259314	-6.5667942729821	49	34	0.0159399906235349	2133	4508	2475,3276,79109,1432,9252,5606,7409,57521,1399,8554,8651,5296,10379,5781,8986,1385,6774,1977,64223,2889,1975,6775,5777,5295,10399,3454,867,7297,9021,5788,10401,2534,1978,6776	MTOR,PRMT1,MAPKAP1,MAPK14,RPS6KA5,MAP2K3,VAV1,RPTOR,CRKL,PIAS1,SOCS1,PIK3R2,IRF9,PTPN11,RPS6KA4,CREB1,STAT3,EIF4E,MLST8,RAPGEF1,EIF4B,STAT4,PTPN6,PIK3R1,GNB2L1,IFNAR1,CBL,TYK2,SOCS3,PTPRC,PIAS3,FYN,EIF4EBP1,STAT5A
WP366	TGF-beta Receptor Signaling Pathway	0.00188609868971589	-6.27324476861293	154	91	0.0426629160806376	2133	4508	10755,1026,1432,898,5606,6497,595,2022,7161,64682,8554,7049,1499,51343,5296,2354,10393,6935,51434,1386,815,9978,1019,3312,467,8928,857,8697,8021,983,4088,7421,817,7514,8881,4800,4087,1616,5933,8312,6500,6093,1855,7029,4089,3172,56288,9839,4208,7323,51433,860,8850,4092,10664,7046,4205,7042,2113,7048,3725,2280,114790,1601,6678,4609,3726,5580,55802,960,6885,4091,818,3837,6667,7050,57559,993,6643,5295,5575,2353,9146,996,94,10131,816,7027,7322,8945,29945	GIPC1,CDKN1A,MAPK14,CCNE1,MAP2K3,SKI,CCND1,ENG,TP73,ANAPC1,PIAS1,TGFBR3,CTNNB1,FZR1,PIK3R2,FOSB,ANAPC10,ZEB1,ANAPC7,ATF2,CAMK2A,RBX1,CDK4,HSPA8,ATF3,FOXH1,CAV1,CDC23,NUP214,CDK1,SMAD3,VDR,CAMK2D,XPO1,CDC16,NFYA,SMAD2,DAXX,RBL1,AXIN1,SKP1,ROCK1,DVL1,TFDP2,SMAD4,HNF4A,PARD3,ZEB2,MEF2C,UBE2D3,ANAPC5,RUNX2,KAT2B,SMAD7,CTCF,TGFBR1,MEF2A,TGFB2,ETS1,TGFBR2,JUN,FKBP1A,STK11IP,DAB2,SPARC,MYC,JUNB,PRKCD,DCP1A,CD44,MAP3K7,SMAD6,CAMK2G,KPNB1,SP1,TGIF1,STAMBPL1,CDC25A,SNX2,PIK3R1,PRKAR1B,FOS,HGS,CDC27,ACVRL1,TRAP1,CAMK2B,TFDP1,UBE2D2,BTRC,ANAPC4
WP244	Alpha6-Beta4 Integrin Signaling Pathway	0.0019298347422778	-6.25032090549424	69	45	0.0210970464135021	2133	4508	2475,3655,977,2064,1026,7531,5578,284217,6714,3914,25,7161,667,3692,3909,6464,5580,5296,5290,8503,3913,4233,9423,1977,5058,3915,207,5295,10971,7431,5747,5339,1832,1956,3921,4088,2534,4087,4486,1978,7534,3691,3911,3918,2810	MTOR,ITGA6,CD151,ERBB2,CDKN1A,YWHAE,PRKCA,LAMA1,SRC,LAMB3,ABL1,TP73,DST,EIF6,LAMA3,SHC1,PRKCD,PIK3R2,PIK3CA,PIK3R3,LAMB2,MET,NTN1,EIF4E,PAK1,LAMC1,AKT1,PIK3R1,YWHAQ,VIM,PTK2,PLEC,DSP,EGFR,RPSA,SMAD3,FYN,SMAD2,MST1R,EIF4EBP1,YWHAZ,ITGB4,LAMA5,LAMC2,SFN
WP2037	Prolactin Signaling Pathway	0.00248707182094138	-5.99664923603286	75	48	0.0225035161744023	2133	4508	5479,2475,5894,8835,7410,2064,1432,6714,140885,7409,3725,1154,5770,6196,8651,6464,4609,5618,4790,5296,5601,5781,5290,3717,1509,6774,5058,5829,207,5295,5747,2316,867,2353,5605,9021,10401,2534,1978,4792,3688,2932,7534,6198,6776,3265,4843,3659	PPIB,MTOR,RAF1,SOCS2,VAV2,ERBB2,MAPK14,SRC,SIRPA,VAV1,JUN,CISH,PTPN1,RPS6KA2,SOCS1,SHC1,MYC,PRLR,NFKB1,PIK3R2,MAPK9,PTPN11,PIK3CA,JAK2,CTSD,STAT3,PAK1,PXN,AKT1,PIK3R1,PTK2,FLNA,CBL,FOS,MAP2K2,SOCS3,PIAS3,FYN,EIF4EBP1,NFKBIA,ITGB1,GSK3B,YWHAZ,RPS6KB1,STAT5A,HRAS,NOS2,IRF1
WP286	IL-3 Signaling Pathway	0.00410811225269785	-5.4947916619002	104	63	0.029535864978903	2133	4508	4318,3397,6403,3635,5894,100500905,6513,8835,619571,6256,22808,1111,5578,4067,5566,1432,6714,1399,7409,5880,1154,6464,4313,5601,5296,4790,5781,5290,3717,1385,6774,1386,6688,7414,6850,2242,6199,3562,5058,5829,5914,30818,2889,207,2931,5777,5295,10971,3845,5747,10399,867,7297,9021,5515,9261,2534,6778,2932,6776,7534,3315,3265	MMP9,ID1,SELP,INPP5D,RAF1,MIR3661,SLC2A1,SOCS2,SNORD96A,RXRA,MRAS,CHEK1,PRKCA,LYN,PRKACA,MAPK14,SRC,CRKL,VAV1,RAC2,CISH,SHC1,MMP2,MAPK9,PIK3R2,NFKB1,PTPN11,PIK3CA,JAK2,CREB1,STAT3,ATF2,SPI1,VCL,SYK,FES,RPS6KB2,IL3,PAK1,PXN,RARA,KCNIP3,RAPGEF1,AKT1,GSK3A,PTPN6,PIK3R1,YWHAQ,KRAS,PTK2,GNB2L1,CBL,TYK2,SOCS3,PPP2CA,MAPKAPK2,FYN,STAT6,GSK3B,STAT5A,YWHAZ,HSPB1,HRAS
WP69	TCR Signaling Pathway	0.00411795260935437	-5.49239917861314	91	56	0.0262541022034693	2133	4508	7189,920,3601,5894,1326,2625,29851,1432,1399,7409,10019,3725,3662,6464,919,5580,3551,5601,5296,4790,5781,1385,6885,9020,1386,5170,5058,10451,27040,207,4690,5295,868,10892,4773,7431,3578,867,2353,4772,5605,9308,355,925,8517,5335,2534,7454,3972,4792,3708,2185,3265,940,1234,9051	TRAF6,CD4,IL15RA,RAF1,MAP3K8,GATA3,ICOS,MAPK14,CRKL,VAV1,SH2B3,JUN,IRF4,SHC1,CD247,PRKCD,IKBKB,MAPK9,PIK3R2,NFKB1,PTPN11,CREB1,MAP3K7,MAP3K14,ATF2,PDPK1,PAK1,VAV3,LAT,AKT1,NCK1,PIK3R1,CBLB,MALT1,NFATC2,VIM,IL9,CBL,FOS,NFATC1,MAP2K2,CD83,FAS,CD8A,IKBKG,PLCG1,FYN,WAS,LHB,NFKBIA,ITPR1,PTK2B,HRAS,CD28,CCR5,PSTPIP1
WP481	Insulin Signaling	0.00444626329208807	-5.41569124520075	163	94	0.0440693858415377	2133	4508	5607,10580,7249,2475,5894,6195,6513,5506,5596,6813,6236,5578,115703,1432,25759,10638,5606,6196,6464,8651,10487,3631,53358,3551,5867,5296,5290,2997,8503,57381,100500810,8986,4294,1977,4215,207,2931,868,867,9064,6009,9021,5167,1978,5590,6722,2932,2887,6198,6300,5563,50488,3636,1958,2888,1326,5562,375,9252,5583,3725,5880,5770,11183,5211,30846,5580,5601,5781,4293,6446,5600,6885,9020,6199,5170,5871,2889,5609,5295,2353,8471,5605,5286,5792,57761,3643,10603,8773,11127,4217,9882,3265,10938	MAP2K5,SORBS1,TSC2,MTOR,RAF1,RPS6KA1,SLC2A1,PPP1R3A,MAPK4,STXBP2,RRAD,PRKCA,ARHGAP33,MAPK14,SHC2,SPHAR,MAP2K3,RPS6KA2,SHC1,SOCS1,CAP1,INPP4A,SHC3,IKBKB,RAB4A,PIK3R2,PIK3CA,GYS1,PIK3R3,RHOJ,MIR3620,RPS6KA4,MAP3K10,EIF4E,MAP3K3,AKT1,GSK3A,CBLB,CBL,MAP3K6,RHEB,SOCS3,ENPP1,EIF4EBP1,PRKCZ,SRF,GSK3B,GRB10,RPS6KB1,MAPK12,PRKAA2,MINK1,INPPL1,EGR1,GRB14,MAP3K8,PRKAA1,ARF1,RPS6KA5,PRKCH,JUN,RAC2,PTPN1,MAP4K5,PFKL,EHD2,PRKCD,MAPK9,PTPN11,MAP3K9,SGK1,MAPK11,MAP3K7,MAP3K14,RPS6KB2,PDPK1,MAP4K2,RAPGEF1,MAP2K7,PIK3R1,FOS,IRS4,MAP2K2,PIK3C2A,PTPRF,TRIB3,INSR,SH2B2,SNAP23,KIF3A,MAP3K5,TBC1D4,HRAS,EHD1
WP2380	BDNF signaling pathway	0.00457380592754847	-5.38740961376389	144	84	0.0393811533052039	2133	4508	391,7189,5607,7249,2475,5894,6195,324,1432,4688,25759,84894,1020,1499,3781,6464,6792,53358,1808,4790,5296,1739,4082,1977,7074,815,1072,207,4690,4914,1959,5515,5335,2534,1978,2185,2932,6198,23373,4208,5563,399694,1958,100500905,619571,7410,5562,4205,9252,6714,140885,3725,650,2890,8878,5580,5601,5864,5781,3717,4904,1385,6774,283106,5170,23191,10451,5923,6868,5295,2902,10399,4804,2353,5605,8851,5792,10603,4792,6776,4776,4915,1000,3265	RHOG,TRAF6,MAP2K5,TSC2,MTOR,RAF1,RPS6KA1,APC,MAPK14,NCF2,SHC2,LINGO1,CDK5,CTNNB1,KCNN2,SHC1,CDKL5,SHC3,DPYSL2,NFKB1,PIK3R2,DLG1,MARCKS,EIF4E,TIAM1,CAMK2A,CFL1,AKT1,NCK1,NTRK1,EGR2,PPP2CA,PLCG1,FYN,EIF4EBP1,PTK2B,GSK3B,RPS6KB1,CRTC1,MEF2C,PRKAA2,SHC4,EGR1,MIR3661,SNORD96A,VAV2,PRKAA1,MEF2A,RPS6KA5,SRC,SIRPA,JUN,BMP2,GRIA1,SQSTM1,PRKCD,MAPK9,RAB3A,PTPN11,JAK2,YBX1,CREB1,STAT3,CSNK2A3,PDPK1,CYFIP1,VAV3,RASGRF1,ADAM17,PIK3R1,GRIN1,GNB2L1,NGFR,FOS,MAP2K2,CDK5R1,PTPRF,SH2B2,NFKBIA,STAT5A,NFATC4,NTRK2,CDH2,HRAS
WP400	p38 MAPK Signaling Pathway	0.00502612392693243	-5.29310618299551	34	24	0.0112517580872011	2133	4508	5321,5923,3150,4149,7186,8550,8737,7046,4209,7042,1432,9252,9261,6464,1616,4609,4293,4217,6885,1385,3315,1386,3265,1649	PLA2G4A,RASGRF1,HMGN1,MAX,TRAF2,MAPKAPK5,RIPK1,TGFBR1,MEF2D,TGFB2,MAPK14,RPS6KA5,MAPKAPK2,SHC1,DAXX,MYC,MAP3K9,MAP3K5,MAP3K7,CREB1,HSPB1,ATF2,HRAS,DDIT3
WP98	Prostaglandin Synthesis and Regulation	0.00649438486097534	-5.0368173429714	31	22	0.0103141115799344	2133	4508	5321,309,5739,307,6916,1906,7356,5732,244,5743,6281,1583,3290,5740,5730,3291,3248,308,5742,302,6277,5731	PLA2G4A,ANXA6,PTGIR,ANXA4,TBXAS1,EDN1,SCGB1A1,PTGER2,ANXA8L2,PTGS2,S100A10,CYP11A1,HSD11B1,PTGIS,PTGDS,HSD11B2,HPGD,ANXA5,PTGS1,ANXA2,S100A6,PTGER1
WP289	Myometrial Relaxation and Contraction Pathways	0.0102414300689169	-4.58131401395398	155	88	0.0412564463197375	2133	4508	5999,71,8601,2782,2870,7531,5578,5566,2783,22809,5331,11318,10268,5998,5336,4790,109,8490,5144,1386,815,5567,3486,113,468,5333,3484,2551,10287,2788,107,10971,467,5577,3710,817,5335,59350,59345,8786,114,58,6001,5590,27297,60,784,10636,23764,3487,5570,6004,2869,8525,3489,1388,57007,489,6000,10267,5997,5996,5583,3725,26575,800,5580,112,3485,51764,1385,818,6667,5575,2786,6262,2353,8787,64407,2114,816,111,3708,3488,408,7534,2980,2810	RGS4,ACTG1,RGS20,GNB1,GRK6,YWHAE,PRKCA,PRKACA,GNB2,ATF5,PLCB3,GPR182,RAMP3,RGS3,PLCG2,NFKB1,ADCY3,RGS5,PDE4D,ATF2,CAMK2A,PRKACB,IGFBP3,ADCY7,ATF4,PLCD1,IGFBP1,GABPA,RGS19,GNG7,ADCY1,YWHAQ,ATF3,PRKAR2B,ITPR3,CAMK2D,PLCG1,RXFP1,GNB4,RGS11,ADCY8,ACTA1,RGS10,PRKCZ,CRCP,ACTB,CACNB3,RGS14,MAFF,IGFBP4,PKIB,RGS16,GRK5,DGKZ,IGFBP6,ATF6B,ACKR3,ATP2A3,RGS7,RAMP1,RGS2,RGS1,PRKCH,JUN,RGS17,CALD1,PRKCD,ADCY6,IGFBP2,GNG13,CREB1,CAMK2G,SP1,PRKAR1B,GNG4,RYR2,FOS,RGS9,RGS18,ETS2,CAMK2B,ADCY5,ITPR1,IGFBP5,ARRB1,YWHAZ,GUCA2A,SFN
WP236	Adipogenesis	0.0105187702130195	-4.55459397840899	132	76	0.0356305672761369	2133	4508	2034,6256,2625,1026,64900,6095,1592,23175,8651,1499,3572,8321,3976,5914,4209,3630,1959,9021,10269,4088,10555,5933,83881,5740,6778,4616,1675,649,28999,688,5054,1855,4208,9612,6695,4205,2688,4154,4000,10135,650,5618,6720,5105,3952,10658,1385,8204,6774,1052,10499,8788,6667,56603,6258,55847,2908,2662,2626,1316,8471,355,1051,1879,3399,57761,1647,183,3091,81029,651,6776,3159,196,1649,8609	EPAS1,RXRA,GATA3,CDKN1A,LPIN3,RORA,CYP26A1,LPIN1,SOCS1,CTNNB1,IL6ST,FZD1,LIF,RARA,MEF2D,INS,EGR2,SOCS3,ZMPSTE24,SMAD3,AGPAT2,RBL1,MIXL1,PTGIS,STAT6,GADD45B,CFD,BMP1,KLF15,KLF5,SERPINE1,DVL1,MEF2C,NCOR2,SPOCK1,MEF2A,GH1,MBNL1,LMNA,NAMPT,BMP2,PRLR,SREBF1,PCK1,LEP,CELF1,CREB1,NRIP1,STAT3,CEBPD,NCOA2,DLK1,SP1,CYP26B1,RXRG,CISD1,NR3C1,GDF10,GATA4,KLF6,IRS4,FAS,CEBPB,EBF1,ID3,TRIB3,GADD45A,AGT,HIF1A,WNT5B,BMP3,STAT5A,HMGA1,AHR,DDIT3,KLF7
WP268	Notch Signaling Pathway	0.0106592171435413	-4.54133030163338	46	30	0.0140646976090014	2133	4508	3280,4851,9612,6868,54567,2648,8850,51107,3955,4242,1488,3714,4853,9253,3762,51763,182,28514,5986,1840,5664,388585,113878,3516,1855,9794,1487,1856,8650,3066	HES1,NOTCH1,NCOR2,ADAM17,DLL4,KAT2A,KAT2B,APH1A,LFNG,MFNG,CTBP2,JAG2,NOTCH2,NUMBL,KCNJ5,INPP5K,JAG1,DLL1,RFNG,DTX1,PSEN2,HES5,DTX2,RBPJ,DVL1,MAML1,CTBP1,DVL2,NUMB,HDAC2
WP1471	TOR signaling	0.0132025671715041	-4.32734398560942	34	23	0.0107829348335677	2133	4508	5563,25989,5564,207,7249,2475,5565,5562,79109,8408,5578,9706,6009,54541,53632,57521,2280,51422,1978,6198,55615,79899,64223	PRKAA2,ULK3,PRKAB1,AKT1,TSC2,MTOR,PRKAB2,PRKAA1,MAPKAP1,ULK1,PRKCA,ULK2,RHEB,DDIT4,PRKAG3,RPTOR,FKBP1A,PRKAG2,EIF4EBP1,RPS6KB1,PRR5,PRR5L,MLST8
WP536	Calcium Regulation in the Cardiac Cell	0.0150735250856862	-4.19481537958416	149	84	0.0393811533052039	2133	4508	5999,8601,2782,2870,7531,5578,844,5566,2783,5331,2781,5998,109,2707,8490,779,148,815,5567,113,2700,57165,492,10287,2788,480,107,10971,2703,1132,5577,481,3710,817,3762,59345,114,8786,6001,5590,784,774,10636,2709,5570,2702,6004,2869,309,489,1128,6000,5997,5996,5583,811,2280,147,26575,5580,112,51764,2771,818,1131,777,773,491,5575,6262,2786,154,2767,8787,5350,64407,486,111,816,3708,408,7534,127534,2810	RGS4,RGS20,GNB1,GRK6,YWHAE,PRKCA,CASQ1,PRKACA,GNB2,PLCB3,GNAZ,RGS3,ADCY3,GJB3,RGS5,CACNA1S,ADRA1A,CAMK2A,PRKACB,ADCY7,GJA3,GJC2,ATP2B3,RGS19,GNG7,ATP1A4,ADCY1,YWHAQ,GJA8,CHRM4,PRKAR2B,ATP1B1,ITPR3,CAMK2D,KCNJ5,GNB4,ADCY8,RGS11,RGS10,PRKCZ,CACNB3,CACNA1B,RGS14,GJB5,PKIB,GJA5,RGS16,GRK5,ANXA6,ATP2A3,CHRM1,RGS7,RGS2,RGS1,PRKCH,CALR,FKBP1A,ADRA1B,RGS17,PRKCD,ADCY6,GNG13,GNAI2,CAMK2G,CHRM3,CACNA1E,CACNA1A,ATP2B2,PRKAR1B,RYR2,GNG4,ADRB2,GNA11,RGS9,PLN,RGS18,FXYD2,ADCY5,CAMK2B,ITPR1,ARRB1,YWHAZ,GJB4,SFN
WP2377	Integrated Pancreatic Cancer Pathway	0.0153624638674768	-4.17582815608775	194	107	0.0501640881387717	2133	4508	5321,1677,4052,10637,92335,3732,5894,6256,2064,324,5596,1026,5578,1432,637,3925,351,898,5154,595,8554,5111,1499,4790,5290,100500810,7159,10411,4661,175,815,3486,3562,5914,9052,207,2931,4690,1630,1019,3326,4914,701,672,820,7422,995,1605,2287,6009,2260,2246,5743,4087,10555,1616,5933,7132,27113,2972,4089,3172,5563,1958,6908,7186,3978,7046,1111,375,641,4485,6714,2280,3725,25,10811,4609,3726,5601,1471,1385,4091,6667,7150,5058,9821,3845,5893,1956,8772,355,7031,3554,5308,5350,1647,10111,4792,6469,356,472,6776,10848,317,4217,43	PLA2G4A,DFFB,LTBP1,LEFTY1,STRADA,CD82,RAF1,RXRA,ERBB2,APC,MAPK4,CDKN1A,PRKCA,MAPK14,BID,STMN1,APP,CCNE1,PDGFA,CCND1,PIAS1,PCNA,CTNNB1,NFKB1,PIK3CA,MIR3620,TP53BP2,RAPGEF3,MYT1,AGA,CAMK2A,IGFBP3,IL3,RARA,GPRC5A,AKT1,GSK3A,NCK1,DCC,CDK4,HSP90AB1,NTRK1,BUB1B,BRCA1,CAMP,VEGFA,CDC25C,DAG1,FKBP3,RHEB,FGFR1,FGF1,PTGS2,SMAD2,AGPAT2,DAXX,RBL1,TNFRSF1A,BBC3,BRF1,SMAD4,HNF4A,PRKAA2,EGR1,TBP,TRAF2,LIG1,TGFBR1,CHEK1,ARF1,BLM,MST1,SRC,FKBP1A,JUN,ABL1,NOXA1,MYC,JUNB,MAPK9,CST3,CREB1,SMAD6,SP1,TOP1,PAK1,RB1CC1,KRAS,RAD52,EGFR,FADD,FAS,TFF1,IL1R1,PITX2,PLN,GADD45A,RAD50,NFKBIA,SHH,FASLG,ATM,STAT5A,PPP1R13L,APAF1,MAP3K5,ACHE
WP1591	Heart Development	0.0163127584045598	-4.11580775313213	47	30	0.0140646976090014	2133	4508	4851,2626,27302,50805,4773,8928,6909,8553,7422,4772,1482,2296,406937,5308,650,4775,3170,9421,1499,2627,406935,6899,6469,5781,6722,4776,2065,657,4089,4208	NOTCH1,GATA4,BMP10,IRX4,NFATC2,FOXH1,TBX2,BHLHE40,VEGFA,NFATC1,NKX2-5,FOXC1,MIR145,PITX2,BMP2,NFATC3,FOXA2,HAND1,CTNNB1,GATA6,MIR143,TBX1,SHH,PTPN11,SRF,NFATC4,ERBB3,BMPR1A,SMAD4,MEF2C
WP138	Androgen receptor signaling pathway	0.0167196444853461	-4.09117093438979	88	52	0.0243788091889358	2133	4508	51588,9612,860,90427,8850,2119,619571,166,64800,1026,7329,6714,11315,898,595,811,3725,56924,8611,8554,7337,1499,5296,6047,1385,6774,10499,10498,6667,207,23598,11143,11034,5295,2274,5747,10399,2316,857,672,5052,1956,388,4088,10401,6049,1616,2932,6093,57178,9604,4089	PIAS4,NCOR2,RUNX2,BMF,KAT2B,ETV5,SNORD96A,AES,EFCAB6,CDKN1A,UBE2I,SRC,PARK7,CCNE1,CCND1,CALR,JUN,PAK6,PPAP2A,PIAS1,UBE3A,CTNNB1,PIK3R2,RNF4,CREB1,STAT3,NCOA2,CARM1,SP1,AKT1,PATZ1,KAT7,DSTN,PIK3R1,FHL2,PTK2,GNB2L1,FLNA,CAV1,BRCA1,PRDX1,EGFR,RHOB,SMAD3,PIAS3,RNF6,DAXX,GSK3B,ROCK1,ZMIZ1,RNF14,SMAD4
WP437	EGFR1 Signaling Pathway	0.0173940519498123	-4.05162697316775	177	98	0.0459446788560713	2133	4508	2005,5753,5607,5894,6195,10928,8737,9712,28964,25942,5578,8290,51079,1432,30011,5606,1399,7409,6196,6464,8651,5899,5336,5296,5290,8503,634,815,4215,10188,207,3855,10318,4690,5777,868,5868,857,867,378,9021,4088,5335,4087,5590,2185,2887,8462,5287,84867,6004,3636,2888,3856,6457,7410,29924,5900,5338,9252,1915,6714,1999,3725,50807,4609,5781,3717,1385,9020,54206,6774,10253,83481,1843,6667,5058,7050,10451,5829,5609,9219,5295,58513,3845,5339,2353,9564,5605,1956,1051,160,2886,6776,5306,5337,9046,3265	ELK4,PTK6,MAP2K5,RAF1,RPS6KA1,RALBP1,RIPK1,USP6NL,GIT1,SIN3A,PRKCA,HIST3H3,NDUFA13,MAPK14,SH3KBP1,MAP2K3,CRKL,VAV1,RPS6KA2,SHC1,SOCS1,RALB,PLCG2,PIK3R2,PIK3CA,PIK3R3,CEACAM1,CAMK2A,MAP3K3,TNK2,AKT1,KRT7,TNIP1,NCK1,PTPN6,CBLB,RAB5A,CAV1,CBL,ARF4,SOCS3,SMAD3,PLCG1,SMAD2,PRKCZ,PTK2B,GRB10,KLF11,PIK3C2B,PTPN5,RGS16,INPPL1,GRB14,KRT8,SH3GL3,VAV2,EPN1,RALGDS,PLD2,RPS6KA5,EEF1A1,SRC,ELF3,JUN,ASAP1,MYC,PTPN11,JAK2,CREB1,MAP3K14,ERRFI1,STAT3,SPRY2,EPPK1,DUSP1,SP1,PAK1,TGIF1,VAV3,PXN,MAP2K7,MTA2,PIK3R1,EPS15L1,KRAS,PLEC,FOS,BCAR1,MAP2K2,EGFR,CEBPB,AP2A1,GRB7,STAT5A,PITPNA,PLD1,DOK2,HRAS
WP51	Regulation of Actin Cytoskeleton	0.0224645178258925	-3.79581820003812	147	82	0.0384435067979372	2133	4508	10163,71,54434,1793,5894,324,5596,22808,55740,28964,4628,5881,5154,7409,56924,55845,5216,5296,5290,8503,7414,1072,5159,54961,2147,2249,2257,87,1132,929,2260,2246,2934,7454,3984,4638,5287,60,6093,2245,4659,2335,8874,1128,5305,10298,23396,2261,5880,23533,10092,9138,6548,5962,623,3672,22800,1131,4634,2264,5058,2254,5829,6237,27006,5295,79837,3845,5747,26999,8394,9564,5605,10458,5286,1956,2248,2768,8817,26281,4478,50649	WASF2,ACTG1,SSH1,DOCK1,RAF1,APC,MAPK4,MRAS,ENAH,GIT1,MYH10,RAC3,PDGFA,VAV1,PAK6,BRK1,PFN1,PIK3R2,PIK3CA,PIK3R3,VCL,CFL1,PDGFRB,SSH3,F2,FGF4,FGF12,ACTN1,CHRM4,CD14,FGFR1,FGF1,GSN,WAS,LIMK1,MYLK,PIK3C2B,ACTB,ROCK1,FGD1,PPP1R12A,FN1,ARHGEF7,CHRM1,PIP4K2A,PAK4,PIP5K1C,FGFR3,RAC2,PIK3R5,ARPC5,ARHGEF1,SLC9A1,RDX,BDKRB1,ITGA1,RRAS2,CHRM3,MYL3,FGFR4,PAK1,FGF9,PXN,RRAS,FGF22,PIK3R1,PIP4K2C,KRAS,PTK2,CYFIP2,PIP5K1A,BCAR1,MAP2K2,BAIAP2,PIK3C2A,EGFR,FGF3,GNA12,FGF18,FGF20,MSN,ARHGEF4
WP2035	FSH signaling pathway	0.0226684623025181	-3.78678064638308	28	19	0.00890764181903422	2133	4508	1588,207,7249,2475,5894,2870,2492,5578,8290,1432,5566,6714,6009,374,1978,6446,6198,1385,6199	CYP19A1,AKT1,TSC2,MTOR,RAF1,GRK6,FSHR,PRKCA,HIST3H3,MAPK14,PRKACA,SRC,RHEB,AREG,EIF4EBP1,SGK1,RPS6KB1,CREB1,RPS6KB2
WP364	IL-6 Signaling Pathway	0.024693764884287	-3.70120450104952	99	57	0.0267229254571027	2133	4508	3636,3635,5894,100500905,2064,51701,4067,1432,7409,3725,1020,6196,6464,5518,3572,5580,5296,4790,5781,6446,3717,2065,3320,5521,6885,6774,1977,2242,5829,28227,207,5295,3570,5747,2353,5605,7297,8851,9021,1051,5515,9261,5529,5335,2268,2534,5525,1616,1978,1025,2185,2932,6198,5522,3315,3265,5528	INPPL1,INPP5D,RAF1,MIR3661,ERBB2,NLK,LYN,MAPK14,VAV1,JUN,CDK5,RPS6KA2,SHC1,PPP2R1A,IL6ST,PRKCD,PIK3R2,NFKB1,PTPN11,SGK1,JAK2,ERBB3,HSP90AA1,PPP2R2B,MAP3K7,STAT3,EIF4E,FES,PXN,PPP2R3B,AKT1,PIK3R1,IL6R,PTK2,FOS,MAP2K2,TYK2,CDK5R1,SOCS3,CEBPB,PPP2CA,MAPKAPK2,PPP2R5E,PLCG1,FGR,FYN,PPP2R5A,DAXX,EIF4EBP1,CDK9,PTK2B,GSK3B,RPS6KB1,PPP2R2C,HSPB1,HRAS,PPP2R5D
WP304	Kit Receptor Signaling Pathway	0.0272397510386783	-3.60307793729185	67	40	0.0187529301453352	2133	4508	200734,10750,3635,5894,6195,7410,5578,4067,6714,30011,25,1399,7409,1154,6464,8651,5296,4286,5781,9306,3717,6774,3815,2242,2057,207,10076,5777,5295,868,867,5335,2268,2534,10603,2886,4254,6776,2887,3265	SPRED2,GRAP,INPP5D,RAF1,RPS6KA1,VAV2,PRKCA,LYN,SRC,SH3KBP1,ABL1,CRKL,VAV1,CISH,SHC1,SOCS1,PIK3R2,MITF,PTPN11,SOCS6,JAK2,STAT3,KIT,FES,EPOR,AKT1,PTPRU,PTPN6,PIK3R1,CBLB,CBL,PLCG1,FGR,FYN,SH2B2,GRB7,KITLG,STAT5A,GRB10,HRAS
WP3	Keap1-Nrf2 Pathway	0.0300223126283626	-3.50581441948938	13	10	0.0046882325363338	2133	4508	1051,9817,2048,1728,5578,7965,4094,3162,4780,5290	CEBPB,KEAP1,EPHB2,NQO1,PRKCA,AIMP2,MAF,HMOX1,NFE2L2,PIK3CA
WP306	Focal Adhesion	0.0304538558485157	-3.4915426639919	184	100	0.046882325363338	2133	4508	5753,8711,5607,1284,71,1793,5894,7148,2064,10420,5596,5881,329,5606,595,5154,7409,56924,7791,3909,6464,53358,7448,1289,5296,1280,5290,22801,3687,4233,8515,1311,3694,7414,5159,10188,1292,207,330,1277,87,2316,857,5228,3689,2534,2321,4638,3681,3688,2932,3082,60,6093,6725,3911,3918,6300,4659,2335,7094,3655,7059,859,284217,6714,10298,3914,23396,640,3725,5880,3696,3675,23533,896,5601,3913,63923,9855,5170,5058,56034,5829,2889,7143,3915,7058,5295,5747,9564,5605,1956,388,29780,2268,10000,7450,3685,3691	PTK6,TNK1,MAP2K5,COL4A2,ACTG1,DOCK1,RAF1,TNXB,ERBB2,TESK2,MAPK4,RAC3,BIRC2,MAP2K3,CCND1,PDGFA,VAV1,PAK6,ZYX,LAMA3,SHC1,SHC3,VTN,COL5A1,PIK3R2,COL2A1,PIK3CA,ITGA11,ITGAX,MET,ITGA10,COMP,ITGB6,VCL,PDGFRB,TNK2,COL6A2,AKT1,BIRC3,COL1A1,ACTN1,FLNA,CAV1,PGF,ITGB2,FYN,FLT1,MYLK,ITGAD,ITGB1,GSK3B,HGF,ACTB,ROCK1,SRMS,LAMA5,LAMC2,MAPK12,PPP1R12A,FN1,TLN1,ITGA6,THBS3,CAV3,LAMA1,SRC,PAK4,LAMB3,PIP5K1C,BLK,JUN,RAC2,ITGB8,ITGA3,PIK3R5,CCND3,MAPK9,LAMB2,TNN,FARP2,PDPK1,PAK1,PDGFC,PXN,RAPGEF1,TNR,LAMC1,THBS2,PIK3R1,PTK2,BCAR1,MAP2K2,EGFR,RHOB,PARVB,FGR,AKT3,VWF,ITGAV,ITGB4
WP61	Delta-Notch Signaling Pathway	0.0346932173955214	-3.36121107524093	85	49	0.0229723394280356	2133	4508	59269,9612,54567,8850,3955,6929,1270,55502,3714,161882,4853,25942,351,3725,4856,9253,182,28514,5296,5664,3717,55294,9794,6774,3280,4851,6868,207,51107,9978,5295,5045,4242,4100,1956,4088,4792,1840,6500,7088,388585,2932,2273,3516,7528,4089,3066,8650,4208	HIVEP3,NCOR2,DLL4,KAT2B,LFNG,TCF3,CNTF,HES6,JAG2,ZFPM1,NOTCH2,SIN3A,APP,JUN,NOV,NUMBL,JAG1,DLL1,PIK3R2,PSEN2,JAK2,FBXW7,MAML1,STAT3,HES1,NOTCH1,ADAM17,AKT1,APH1A,RBX1,PIK3R1,FURIN,MFNG,MAGEA1,EGFR,SMAD3,NFKBIA,DTX1,SKP1,TLE1,HES5,GSK3B,FHL1,RBPJ,YY1,SMAD4,HDAC2,NUMB,MEF2C
WP1403	AMPK signaling	0.0365059754465872	-3.31027932092745	68	40	0.0187529301453352	2133	4508	5563,5564,7249,2475,5565,84254,92335,133522,5562,56731,1026,891,29904,147,57521,5296,6720,5290,2997,8503,3952,148,5567,6199,3156,10645,207,5295,2194,5209,55437,53632,200186,51422,3643,1978,6198,51094,723961,3172	PRKAA2,PRKAB1,TSC2,MTOR,PRKAB2,CAMKK1,STRADA,PPARGC1B,PRKAA1,SLC2A4RG,CDKN1A,CCNB1,EEF2K,ADRA1B,RPTOR,PIK3R2,SREBF1,PIK3CA,GYS1,PIK3R3,LEP,ADRA1A,PRKACB,RPS6KB2,HMGCR,CAMKK2,AKT1,PIK3R1,FASN,PFKFB3,STRADB,PRKAG3,CRTC2,PRKAG2,INSR,EIF4EBP1,RPS6KB1,ADIPOR1,INS-IGF2,HNF4A
WP673	ErbB signaling pathway	0.0391819200944295	-3.23953986066222	55	33	0.0154711673699015	2133	4508	685,1839,2475,2064,9542,1026,5578,6714,10298,25759,25,595,3725,23533,4609,2065,815,5609,4690,7039,3845,5747,1956,5335,10718,374,1978,10000,2932,6198,3084,6776,3265	BTC,HBEGF,MTOR,ERBB2,NRG2,CDKN1A,PRKCA,SRC,PAK4,SHC2,ABL1,CCND1,JUN,PIK3R5,MYC,ERBB3,CAMK2A,MAP2K7,NCK1,TGFA,KRAS,PTK2,EGFR,PLCG1,NRG3,AREG,EIF4EBP1,AKT3,GSK3B,RPS6KB1,NRG1,STAT5A,HRAS
WP560	TGF Beta Signaling Pathway	0.0391819200944295	-3.23953986066222	55	33	0.0154711673699015	2133	4508	4052,860,10637,4092,7046,4090,7048,6497,2022,3725,2280,7049,1499,5601,9241,4790,23090,4091,6774,3694,3976,7050,7044,8928,864,2353,4088,4087,25805,5054,3265,4089,9839	LTBP1,RUNX2,LEFTY1,SMAD7,TGFBR1,SMAD5,TGFBR2,SKI,ENG,JUN,FKBP1A,TGFBR3,CTNNB1,MAPK9,NOG,NFKB1,ZNF423,SMAD6,STAT3,ITGB6,LIF,TGIF1,LEFTY2,FOXH1,RUNX3,FOS,SMAD3,SMAD2,BAMBI,SERPINE1,HRAS,SMAD4,ZEB2
WP2038	Regulation of Microtubule Cytoskeleton	0.0422807229901034	-3.16342401807655	44	27	0.0126582278481013	2133	4508	5058,4139,22919,207,7204,10420,324,11004,5578,3925,5566,983,2011,6714,9261,25,2048,3984,1808,5290,2932,1855,6093,89780,6774,7074,11076	PAK1,MARK1,MAPRE1,AKT1,TRIO,TESK2,APC,KIF2C,PRKCA,STMN1,PRKACA,CDK1,MARK2,SRC,MAPKAPK2,ABL1,EPHB2,LIMK1,DPYSL2,PIK3CA,GSK3B,DVL1,ROCK1,WNT3A,STAT3,TIAM1,TPPP
WP197	Cholesterol biosynthesis	0.0456102543701523	-3.08762271120431	17	12	0.00562587904360056	2133	4508	4047,3157,3422,4598,6307,2224,6720,6713,10654,1717,3156,2222	LSS,HMGCS1,IDI1,MVK,MSMO1,FDPS,SREBF1,SQLE,PMVK,DHCR7,HMGCR,FDFT1
WP23	B Cell Receptor Signaling Pathway	0.0485048302660287	-3.02609189288377	159	86	0.0403187998124707	2133	4508	3635,5894,6195,10096,5596,3937,4067,1432,898,921,7409,1399,5164,1499,6464,3551,5336,5296,5911,2969,1386,26469,207,2931,4690,5777,1019,868,1380,4773,59338,1846,867,4772,79930,8517,5335,2534,7454,51363,2185,2932,6198,54923,4739,7410,54205,5305,123920,23396,3725,640,973,4775,10092,84174,933,51564,5580,896,27071,5781,6885,1385,6774,59339,6850,5170,2213,2889,6452,974,5295,79837,5747,8394,9564,29760,5605,9261,5788,10603,4792,3708,975,493	INPP5D,RAF1,RPS6KA1,ACTR3,MAPK4,LCP2,LYN,MAPK14,CCNE1,CD5,VAV1,CRKL,PDK2,CTNNB1,SHC1,IKBKB,PLCG2,PIK3R2,RAP2A,GTF2I,ATF2,PTPN18,AKT1,GSK3A,NCK1,PTPN6,CDK4,CBLB,CR2,NFATC2,PLEKHA1,DUSP4,CBL,NFATC1,DOK3,IKBKG,PLCG1,FYN,WAS,CHST15,PTK2B,GSK3B,RPS6KB1,LIME1,NEDD9,VAV2,CYCS,PIP4K2A,CMTM3,PIP5K1C,JUN,BLK,CD79A,NFATC3,ARPC5,SLA2,CD22,HDAC7,PRKCD,CCND3,DAPP1,PTPN11,MAP3K7,CREB1,STAT3,PLEKHA2,SYK,PDPK1,FCGR2B,RAPGEF1,SH3BP2,CD79B,PIK3R1,PIP4K2C,PTK2,PIP5K1A,BCAR1,BLNK,MAP2K2,MAPKAPK2,PTPRC,SH2B2,NFKBIA,ITPR1,CD81,ATP2B4
WP53	Id Signaling Pathway	0.0497513920760404	-3.00071683434106	52	31	0.0145335208626348	2133	4508	2005,3280,7050,3397,2004,4656,6929,5076,3398,467,4090,3400,5710,7422,898,6934,650,4088,3399,1499,94,7015,7849,5933,2321,4790,6720,4654,5079,4089,3428	ELK4,HES1,TGIF1,ID1,ELK3,MYOG,TCF3,PAX2,ID2,ATF3,SMAD5,ID4,PSMD4,VEGFA,CCNE1,TCF7L2,BMP2,SMAD3,ID3,CTNNB1,ACVRL1,TERT,PAX8,RBL1,FLT1,NFKB1,SREBF1,MYOD1,PAX5,SMAD4,IFI16
WP2064	Neural Crest Differentiation	0.0601455925183652	-2.81098711408633	101	56	0.0262541022034693	2133	4508	3397,54567,79885,3975,6662,1488,83933,4853,10013,5081,2113,2637,9734,2261,127343,1499,28514,999,51564,4609,64211,1280,4286,4790,85416,7020,4791,89780,1856,4762,6591,3280,4851,4487,4155,8929,7021,8841,6663,6911,388,2260,7478,83439,4488,9421,9759,4359,8312,3688,388585,2932,3516,1855,1000,3066	ID1,DLL4,HDAC11,LHX1,SOX9,CTBP2,HDAC10,NOTCH2,HDAC6,PAX7,ETS1,GBX2,HDAC9,FGFR3,DMBX1,CTNNB1,DLL1,CDH1,HDAC7,MYC,LHX5,COL2A1,MITF,NFKB1,ZIC5,TFAP2A,NFKB2,WNT3A,DVL2,NEUROG1,SNAI2,HES1,NOTCH1,MSX1,MBP,PHOX2B,TFAP2B,HDAC3,SOX10,TBX6,RHOB,FGFR1,WNT8A,TCF7L1,MSX2,HAND1,HDAC4,MPZ,AXIN1,ITGB1,HES5,GSK3B,RBPJ,DVL1,CDH2,HDAC2
WP334	GPCRs, Class B Secretin-like	0.064681738703567	-2.73827636300858	23	15	0.0070323488045007	2133	4508	7433,9340,1395,5745,2740,2642,22859,6344,976,64123,7434,23266,117,23284,2015	VIPR1,GLP2R,CRHR2,PTH1R,GLP1R,GCGR,LPHN1,SCTR,CD97,ELTD1,VIPR2,LPHN2,ADCYAP1R1,LPHN3,EMR1
WP382	MAPK signaling pathway	0.0781108340709063	-2.54962651125914	166	88	0.0412564463197375	2133	4508	7189,5607,4149,5894,51701,5596,22808,3925,5495,5566,1432,3303,1399,3551,4790,11221,994,140738,1386,5159,1849,468,207,2249,4914,4909,3312,3309,8550,929,2316,1846,9064,8399,8517,2645,1616,23118,5590,5778,6722,5533,5536,3315,6300,4208,84867,9344,50488,839,7186,5922,1326,23162,7046,7042,7048,1847,5583,3725,5880,6788,4609,5580,5601,6885,9020,1843,5058,5609,3164,51295,3845,2353,5605,1956,3304,355,9261,3554,2768,1647,10000,356,408,4217,51776,1649	TRAF6,MAP2K5,MAX,RAF1,NLK,MAPK4,MRAS,STMN1,PPM1B,PRKACA,MAPK14,HSPA1A,CRKL,IKBKB,NFKB1,DUSP10,CDC25B,TMEM37,ATF2,PDGFRB,DUSP7,ATF4,AKT1,FGF4,NTRK1,NTF4,HSPA8,HSPA5,MAPKAPK5,CD14,FLNA,DUSP4,MAP3K6,PLA2G10,IKBKG,GCK,DAXX,TAB2,PRKCZ,PTPN7,SRF,PPP3CC,PPP5C,HSPB1,MAPK12,MEF2C,PTPN5,TAOK2,MINK1,CASP6,TRAF2,RASA2,MAP3K8,MAPK8IP3,TGFBR1,TGFB2,TGFBR2,DUSP5,PRKCH,JUN,RAC2,STK3,MYC,PRKCD,MAPK9,MAP3K7,MAP3K14,DUSP1,PAK1,MAP2K7,NR4A1,ECSIT,KRAS,FOS,MAP2K2,EGFR,HSPA1B,FAS,MAPKAPK2,IL1R1,GNA12,GADD45A,AKT3,FASLG,ARRB1,MAP3K5,ZAK,DDIT3
WP1772	Apoptosis Modulation and Signaling	0.0821248304551703	-2.49951486665231	79	44	0.0206282231598687	2133	4508	7189,1677,90427,57448,839,2021,54205,8718,637,329,8837,640,3725,8771,9531,3654,5366,3551,4790,664,9020,578,330,5783,8743,826,4170,2353,54472,8772,355,3554,1616,4792,7132,356,27113,4982,7187,317,8793,4217,666,10017	TRAF6,DFFB,BMF,BIRC6,CASP6,ENDOG,CYCS,TNFRSF25,BID,BIRC2,CFLAR,BLK,JUN,TNFRSF6B,BAG3,IRAK1,PMAIP1,IKBKB,NFKB1,BNIP3,MAP3K14,BAK1,BIRC3,PTPN13,TNFSF10,CAPNS1,MCL1,FOS,TOLLIP,FADD,FAS,IL1R1,DAXX,NFKBIA,TNFRSF1A,FASLG,BBC3,TNFRSF11B,TRAF3,APAF1,TNFRSF10D,MAP3K5,BOK,BCL2L10
WP2112	IL17 signaling pathway	0.0832400410014785	-2.4860267848874	31	19	0.00890764181903422	2133	4508	7189,207,27190,84818,10758,1051,132014,8517,4790,3551,2932,7187,3717,27189,6885,9020,6774,1052,6667	TRAF6,AKT1,IL17B,IL17RC,TRAF3IP2,CEBPB,IL17RE,IKBKG,NFKB1,IKBKB,GSK3B,TRAF3,JAK2,IL17C,MAP3K7,MAP3K14,STAT3,CEBPD,SP1
WP185	Integrin-mediated cell adhesion	0.0877873222148869	-2.43283818267476	99	54	0.0253164556962025	2133	4508	5607,10580,1793,7094,8874,5894,3655,7410,5596,859,6714,10298,5881,5606,824,56924,7791,5880,3696,6464,3675,53358,5296,22801,3672,3687,8515,3694,7414,10753,5170,5058,10451,5829,2889,207,826,7145,5747,857,9564,5605,3689,2534,10000,3681,3688,11132,11131,3685,6093,3691,3265,6300	MAP2K5,SORBS1,DOCK1,TLN1,ARHGEF7,RAF1,ITGA6,VAV2,MAPK4,CAV3,SRC,PAK4,RAC3,MAP2K3,CAPN2,PAK6,ZYX,RAC2,ITGB8,SHC1,ITGA3,SHC3,PIK3R2,ITGA11,ITGA1,ITGAX,ITGA10,ITGB6,VCL,CAPN9,PDPK1,PAK1,VAV3,PXN,RAPGEF1,AKT1,CAPNS1,TNS1,PTK2,CAV1,BCAR1,MAP2K2,ITGB2,FYN,AKT3,ITGAD,ITGB1,CAPN10,CAPN11,ITGAV,ROCK1,ITGB4,HRAS,MAPK12
WP615	Senescence and Autophagy	0.089130253221361	-2.41765645980954	107	58	0.0271917487107361	2133	4508	3916,7405,2335,2475,5894,8408,1026,1432,6714,27173,5055,5606,3490,650,3725,55630,5111,8878,7448,6678,3572,11009,4323,994,960,3486,64223,440738,3562,3621,9821,8804,1277,55054,11345,9140,3570,84557,3630,23710,1051,4088,2934,3576,3488,83734,9547,2932,3665,5054,3159,6041,9474,29985,3265,4089,3428,3659	LAMP1,UVRAG,FN1,MTOR,RAF1,ULK1,CDKN1A,MAPK14,SRC,SLC39A1,SERPINB2,MAP2K3,IGFBP7,BMP2,JUN,SLC39A4,PCNA,SQSTM1,VTN,SPARC,IL6ST,IL24,MMP14,CDC25B,CD44,IGFBP3,MLST8,MAP1LC3C,IL3,ING1,RB1CC1,CREG1,COL1A1,ATG16L1,GABARAPL2,ATG12,IL6R,MAP1LC3A,INS,GABARAPL1,CEBPB,SMAD3,GSN,IL8,IGFBP5,ATG10,CXCL14,GSK3B,IRF7,SERPINE1,HMGA1,RNASEL,ATG5,SLC39A3,HRAS,SMAD4,IFI16,IRF1
WP262	EBV LMP1 signaling	0.0928207174621902	-2.37708541559124	22	14	0.00656352555086732	2133	4508	9260,4215,8517,7189,3654,7185,6364,3551,3576,4790,3320,6885,9020,4791	PDLIM7,MAP3K3,IKBKG,TRAF6,IRAK1,TRAF1,CCL20,IKBKB,IL8,NFKB1,HSP90AA1,MAP3K7,MAP3K14,NFKB2
WP395	IL-4 signaling Pathway	0.0942029565657989	-2.36230371184353	64	36	0.0168776371308017	2133	4508	126961,3635,3565,2113,1432,6714,8651,6464,5580,5296,4790,5781,5290,653604,3717,5600,3566,6688,1386,2242,207,5777,5295,5747,867,7297,9021,5335,2534,6778,5590,6198,6776,3159,9046,333932	HIST2H3C,INPP5D,IL4,ETS1,MAPK14,SRC,SOCS1,SHC1,PRKCD,PIK3R2,NFKB1,PTPN11,PIK3CA,HIST2H3D,JAK2,MAPK11,IL4R,SPI1,ATF2,FES,AKT1,PTPN6,PIK3R1,PTK2,CBL,TYK2,SOCS3,PLCG1,FYN,STAT6,PRKCZ,RPS6KB1,STAT5A,HMGA1,DOK2,HIST2H3A
WP2324	AGE/RAGE pathway	0.0952945653734713	-2.35078249645937	66	37	0.0173464603844351	2133	4508	4318,5321,5894,54205,5578,1432,6714,3725,6464,3625,5580,3551,653361,4790,5601,4313,4323,3717,6774,1386,6667,6647,207,1729,3630,1956,4088,4087,3643,1650,3091,4792,5590,6776,6093,4478,4843	MMP9,PLA2G4A,RAF1,CYCS,PRKCA,MAPK14,SRC,JUN,SHC1,INHBB,PRKCD,IKBKB,NCF1,NFKB1,MAPK9,MMP2,MMP14,JAK2,STAT3,ATF2,SP1,SOD1,AKT1,DIAPH1,INS,EGFR,SMAD3,SMAD2,INSR,DDOST,HIF1A,NFKBIA,PRKCZ,STAT5A,ROCK1,MSN,NOS2
WP2436	Dopamine metabolism	0.095361156111374	-2.35008395208743	13	9	0.00421940928270042	2133	4508	5515,6647,1728,4128,7299,1312,5566,1644,5567	PPP2CA,SOD1,NQO1,MAOA,TYR,COMT,PRKACA,DDC,PRKACB
WP325	Triacylglyceride Synthesis	0.098656950094901	-2.31610659694343	24	15	0.0070323488045007	2133	4508	8611,10555,55326,346606,56895,57104,8443,84649,8612,80168,56894,57678,8694,3990,2819	PPAP2A,AGPAT2,AGPAT5,MOGAT3,AGPAT4,PNPLA2,GNPAT,DGAT2,PPAP2C,MOGAT2,AGPAT3,GPAM,DGAT1,LIPC,GPD1
WP179	Cell cycle	0.105491376957777	-2.24912606440388	102	55	0.0257852789498359	2133	4508	9134,55388,10926,1111,375,1026,10013,7531,891,898,25,4173,7465,5111,999,4174,51564,896,8379,100500810,699,545,994,993,4999,9184,902,5591,1019,8841,991,1871,10971,701,990,9088,4221,4171,995,983,4088,1647,9759,5933,7027,8243,84515,472,2932,4254,7534,1870,4089,4172,3066	CCNE2,MCM10,DBF4,CHEK1,ARF1,CDKN1A,HDAC6,YWHAE,CCNB1,CCNE1,ABL1,MCM4,WEE1,PCNA,CDH1,MCM5,HDAC7,CCND3,MAD1L1,MIR3620,BUB1,ATR,CDC25B,CDC25A,ORC2,BUB3,CCNH,PRKDC,CDK4,HDAC3,CDC20,E2F3,YWHAQ,BUB1B,CDC6,PKMYT1,MEN1,MCM2,CDC25C,CDK1,SMAD3,GADD45A,HDAC4,RBL1,TFDP1,SMC1A,MCM8,ATM,GSK3B,KITLG,YWHAZ,E2F2,SMAD4,MCM3,HDAC2
WP2516	ATM Signaling Pathway	0.105851947490662	-2.24571388298136	3	3	0.00140646976090014	2133	4508	1647,1385,891	GADD45A,CREB1,CCNB1
WP2276	Glial Cell Differentiation	0.111891453933431	-2.19022603893617	8	6	0.00281293952180028	2133	4508	4155,4099,1267,4478,2596,11076	MBP,MAG,CNP,MSN,GAP43,TPPP
WP134	Pentose Phosphate Pathway	0.111891453933431	-2.19022603893617	8	6	0.00281293952180028	2133	4508	6120,25796,6888,7086,22934,5226	RPE,PGLS,TALDO1,TKT,RPIA,PGD
WP107	Translation Factors	0.113309950346108	-2.17762829180255	57	32	0.0150023441162682	2133	4508	8663,8664,1964,9451,8672,3646,1915,29904,3692,23277,10209,2107,1983,1977,26986,1936,1984,1975,27102,1973,8890,7458,8666,8667,1981,1968,1978,8892,8891,8662,8637,100500804	EIF3C,EIF3D,EIF1AX,EIF2AK3,EIF4G3,EIF3E,EEF1A1,EEF2K,EIF6,CLUH,EIF1,ETF1,EIF5,EIF4E,PABPC1,EEF1D,EIF5A,EIF4B,EIF2AK1,EIF4A1,EIF2B4,EIF4H,EIF3G,EIF3H,EIF4G1,EIF2S3,EIF4EBP1,EIF2B2,EIF2B3,EIF3B,EIF4EBP3,MIR3654
WP408	Oxidative Stress	0.116357582200842	-2.15108722418186	32	19	0.00890764181903422	2133	4508	7296,6647,2878,1728,100129518,3162,2353,1432,4784,847,653689,4790,3726,4128,54578,25828,2876,4780,6667	TXNRD1,SOD1,GPX3,NQO1,LOC100129518,HMOX1,FOS,MAPK14,NFIX,CAT,GSTT2B,NFKB1,JUNB,MAOA,UGT1A6,TXN2,GPX1,NFE2L2,SP1
WP1991	SRF and miRs in Smooth Muscle Differentiation and Proliferation	0.123881670748631	-2.08842843713703	19	12	0.00562587904360056	2133	4508	817,406923,406935,9314,6722,4205,100422882,4209,1482,406937,406976,4208	CAMK2D,MIR133A2,MIR143,KLF4,SRF,MEF2A,MIR3120,MEF2D,NKX2-5,MIR145,MIR199A1,MEF2C
WP2203	TSLP Signaling Pathway	0.125413492899218	-2.07613905769432	38	22	0.0103141115799344	2133	4508	207,2475,6775,1432,5605,55361,1154,1978,6778,4609,5601,4790,3576,4792,5290,5781,5971,3717,6776,7292,4791,6774	AKT1,MTOR,STAT4,MAPK14,MAP2K2,PI4K2A,CISH,EIF4EBP1,STAT6,MYC,MAPK9,NFKB1,IL8,NFKBIA,PIK3CA,PTPN11,RELB,JAK2,STAT5A,TNFSF4,NFKB2,STAT3
WP2332	Interleukin-11 Signaling Pathway	0.127856016586239	-2.0568505186241	40	23	0.0107829348335677	2133	4508	5170,860,3590,207,632,5894,6195,5295,7297,6714,3383,9021,10401,8554,2534,3572,5296,3551,5781,3717,1385,6774,3265	PDPK1,RUNX2,IL11RA,AKT1,BGLAP,RAF1,RPS6KA1,PIK3R1,TYK2,SRC,ICAM1,SOCS3,PIAS3,PIAS1,FYN,IL6ST,PIK3R2,IKBKB,PTPN11,JAK2,CREB1,STAT3,HRAS
WP167	Eicosanoid Synthesis	0.130711807127404	-2.03476032480856	21	13	0.00609470229723394	2133	4508	240,2678,5743,4056,5740,5730,6916,1800,5742,50640,4048,9536,8398	ALOX5,GGT1,PTGS2,LTC4S,PTGIS,PTGDS,TBXAS1,DPEP1,PTGS1,PNPLA8,LTA4H,PTGES,PLA2G6
WP2333	Trans-sulfuration pathway	0.131104991053625	-2.03175681835267	10	7	0.00328176277543366	2133	4508	27430,875,51380,2805,191,4548,1491	MAT2B,CBS,CSAD,GOT1,AHCY,MTR,CTH
WP2272	Pathogenic Escherichia coli infection	0.140519185916858	-1.96241124496268	56	31	0.0145335208626348	2133	4508	7280,81873,71,4690,10383,10971,4691,929,84617,112714,5578,10552,10376,25,7454,7278,2534,999,1499,10092,51807,3688,9181,7534,60,6093,2017,347688,7100,10381,7277	TUBB2A,ARPC5L,ACTG1,NCK1,TUBB4B,YWHAQ,NCL,CD14,TUBB6,TUBA3E,PRKCA,ARPC1A,TUBA1B,ABL1,WAS,TUBA3C,FYN,CDH1,CTNNB1,ARPC5,TUBA8,ITGB1,ARHGEF2,YWHAZ,ACTB,ROCK1,CTTN,TUBB8,TLR5,TUBB3,TUBA4A
WP428	Wnt Signaling Pathway	0.142341036560667	-1.94952943485098	60	33	0.0154711673699015	2133	4508	8325,7472,11211,3949,324,5578,8323,5583,595,3725,1499,80326,4609,896,5580,5601,89780,1856,8321,1454,7476,7477,7481,5529,54361,7475,8312,81029,5590,2932,1855,7855,8061	FZD8,WNT2,FZD10,LDLR,APC,PRKCA,FZD6,PRKCH,CCND1,JUN,CTNNB1,WNT10A,MYC,CCND3,PRKCD,MAPK9,WNT3A,DVL2,FZD1,CSNK1E,WNT7A,WNT7B,WNT11,PPP2R5E,WNT4,WNT6,AXIN1,WNT5B,PRKCZ,GSK3B,DVL1,FZD5,FOSL1
WP2032	TSH signaling pathway	0.143792719551432	-1.93938246396553	64	35	0.0164088138771683	2133	4508	2475,5894,6195,5900,2782,1432,6714,898,5606,3725,4609,5296,896,5290,8458,109,3717,5144,1385,6774,2771,5170,30818,207,1019,5295,23513,2353,2768,7849,6198,5337,5909,3265,103910	MTOR,RAF1,RPS6KA1,RALGDS,GNB1,MAPK14,SRC,CCNE1,MAP2K3,JUN,MYC,PIK3R2,CCND3,PIK3CA,TTF2,ADCY3,JAK2,PDE4D,CREB1,STAT3,GNAI2,PDPK1,KCNIP3,AKT1,CDK4,PIK3R1,SCRIB,FOS,GNA12,PAX8,RPS6KB1,PLD1,RAP1GAP,HRAS,MYL12B
WP1425	BMP signalling and regulation	0.14583230836788	-1.92529789021181	12	8	0.00375058602906704	2133	4508	650,860,9241,10766,657,4091,10140,4089	BMP2,RUNX2,NOG,TOB2,BMPR1A,SMAD6,TOB1,SMAD4
WP391	Mitochondrial Gene Expression	0.14583230836788	-1.92529789021181	12	8	0.00375058602906704	2133	4508	3054,51106,64216,133522,51001,2101,6667,5442	HCFC1,TFB1M,TFB2M,PPARGC1B,MTERFD1,ESRRA,SP1,POLRMT
WP688	Catalytic cycle of mammalian FMOs	0.155609956411085	-1.86040268206717	5	4	0.00187529301453352	2133	4508	2326,2327,2329,2328	FMO1,FMO2,FMO4,FMO3
WP313	Signaling of Hepatocyte Growth Factor Receptor	0.15630326447582	-1.85595715581108	33	19	0.00890764181903422	2133	4508	5058,5829,2889,1793,5894,5747,2353,6714,5605,3725,1399,5290,3688,5781,2185,3082,3672,6774,3265	PAK1,PXN,RAPGEF1,DOCK1,RAF1,PTK2,FOS,SRC,MAP2K2,JUN,CRKL,PIK3CA,ITGB1,PTPN11,PTK2B,HGF,ITGA1,STAT3,HRAS
WP58	Monoamine GPCRs	0.15630326447582	-1.85595715581108	33	19	0.00890764181903422	2133	4508	152,3354,3358,1128,1132,154,3360,1815,3274,3352,147,3363,1816,3362,148,1131,3269,1812,150	ADRA2C,HTR1E,HTR2C,CHRM1,CHRM4,ADRB2,HTR4,DRD4,HRH2,HTR1D,ADRA1B,HTR7,DRD5,HTR6,ADRA1A,CHRM3,HRH1,DRD1,ADRA2A
WP2036	TWEAK Signaling Pathway	0.166509390731721	-1.79270357036098	43	24	0.0112517580872011	2133	4508	4318,207,330,7186,5894,8737,1432,329,8772,3725,7185,1499,3551,5601,4790,4792,6469,2932,5971,7187,51330,4791,6885,7188	MMP9,AKT1,BIRC3,TRAF2,RAF1,RIPK1,MAPK14,BIRC2,FADD,JUN,TRAF1,CTNNB1,IKBKB,MAPK9,NFKB1,NFKBIA,SHH,GSK3B,RELB,TRAF3,TNFRSF12A,NFKB2,MAP3K7,TRAF5
WP2374	Oncostatin M Signaling Pathway	0.174103399032879	-1.74810590894723	63	34	0.0159399906235349	2133	4508	1958,2475,5894,3949,5578,1432,6714,5583,6464,3491,3572,3726,5580,4790,5601,5781,3717,1385,6774,5829,207,5295,3845,2353,5605,7297,9021,10401,1051,4792,9180,2185,5054,3265	EGR1,MTOR,RAF1,LDLR,PRKCA,MAPK14,SRC,PRKCH,SHC1,CYR61,IL6ST,JUNB,PRKCD,NFKB1,MAPK9,PTPN11,JAK2,CREB1,STAT3,PXN,AKT1,PIK3R1,KRAS,FOS,MAP2K2,TYK2,SOCS3,PIAS3,CEBPB,NFKBIA,OSMR,PTK2B,SERPINE1,HRAS
WP707	DNA damage response	0.174500919764548	-1.74582526649654	67	36	0.0168776371308017	2133	4508	9134,63970,1111,54205,1026,891,637,898,25,6118,595,1020,5366,4609,896,545,1385,1643,993,1019,5893,672,27244,995,983,355,1647,50484,4616,10111,8243,472,27113,317,5981,2810	CCNE2,TP53AIP1,CHEK1,CYCS,CDKN1A,CCNB1,BID,CCNE1,ABL1,RPA2,CCND1,CDK5,PMAIP1,MYC,CCND3,ATR,CREB1,DDB2,CDC25A,CDK4,RAD52,BRCA1,SESN1,CDC25C,CDK1,FAS,GADD45A,RRM2B,GADD45B,RAD50,SMC1A,ATM,BBC3,APAF1,RFC1,SFN
WP516	Hypertrophy Model	0.180334068668236	-1.71294421116937	20	12	0.00562587904360056	2133	4508	3554,3475,1839,4656,3491,1978,9948,6935,467,3606,7422,1977	IL1R1,IFRD1,HBEGF,MYOG,CYR61,EIF4EBP1,WDR1,ZEB1,ATF3,IL18,VEGFA,EIF4E
WP712	Estrogen signaling pathway	0.180334068668236	-1.71294421116937	20	12	0.00562587904360056	2133	4508	3725,207,5601,4790,5290,2782,2852,1385,2353,1432,5566,6667	JUN,AKT1,MAPK9,NFKB1,PIK3CA,GNB1,GPER1,CREB1,FOS,MAPK14,PRKACA,SP1
WP528	Acetylcholine Synthesis	0.184737477729991	-1.68881950099093	7	5	0.0023441162681669	2133	4508	5161,5160,10400,43,1103	PDHA2,PDHA1,PEMT,ACHE,CHAT
WP34	Ovarian Infertility Genes	0.200895111212555	-1.60497234188961	32	18	0.00843881856540084	2133	4508	1588,1958,1019,23224,6609,4439,5732,7784,3973,2492,1051,7421,4088,2516,5618,472,8204,2661	CYP19A1,EGR1,CDK4,SYNE2,SMPD1,MSH5,PTGER2,ZP3,LHCGR,FSHR,CEBPB,VDR,SMAD3,NR5A1,PRLR,ATM,NRIP1,GDF9
WP2355	Corticotropin-releasing hormone	0.201746012580017	-1.60074573619088	90	47	0.0220346929207689	2133	4508	5563,3728,1589,5894,8912,2782,3606,2870,2355,5578,1432,2783,3713,1395,1499,2781,3726,5580,5336,4790,2354,5601,7020,3320,1889,1385,2771,815,10499,6667,142,207,3164,5747,2353,2767,10155,9095,5335,1584,1583,4792,408,2932,4929,4217,8061	PRKAA2,JUP,CYP21A2,RAF1,CACNA1H,GNB1,IL18,GRK6,FOSL2,PRKCA,MAPK14,GNB2,IVL,CRHR2,CTNNB1,GNAZ,JUNB,PRKCD,PLCG2,NFKB1,FOSB,MAPK9,TFAP2A,HSP90AA1,ECE1,CREB1,GNAI2,CAMK2A,NCOA2,SP1,PARP1,AKT1,NR4A1,PTK2,FOS,GNA11,TRIM28,TBX19,PLCG1,CYP11B1,CYP11A1,NFKBIA,ARRB1,GSK3B,NR4A2,MAP3K5,FOSL1
WP2290	RalA downstream regulated genes	0.203752987945515	-1.59084686220543	9	6	0.00281293952180028	2133	4508	5898,5880,55770,10928,5881,149371	RALA,RAC2,EXOC2,RALBP1,RAC3,EXOC8
WP45	G1 to S cell cycle control	0.207768058987415	-1.57133292249058	68	36	0.0168776371308017	2133	4508	9134,1028,1388,1026,891,898,6118,595,4173,7465,5111,4609,4174,896,1385,1032,4661,901,993,4999,148327,5558,902,1019,1871,90993,4171,983,1647,5426,5933,7027,472,7029,1870,4172	CCNE2,CDKN1C,ATF6B,CDKN1A,CCNB1,CCNE1,RPA2,CCND1,MCM4,WEE1,PCNA,MYC,MCM5,CCND3,CREB1,CDKN2D,MYT1,CCNG2,CDC25A,ORC2,CREB3L4,PRIM2,CCNH,CDK4,E2F3,CREB3L1,MCM2,CDK1,GADD45A,POLE,RBL1,TFDP1,ATM,TFDP2,E2F2,MCM3
WP1984	Integrated Breast Cancer Pathway	0.223218980028128	-1.49960201612202	154	78	0.0365682137834037	2133	4508	1588,4149,7249,2475,6597,5284,637,580,595,8554,7465,1499,999,4790,5296,994,221002,4661,140739,1263,578,2241,207,2931,10557,1019,672,7422,1605,27005,6009,5898,4087,10913,28996,55526,7517,657,4089,1453,9958,5245,64781,4092,7046,1111,8438,641,7048,152789,3725,25,10811,4609,84640,58515,545,1385,4091,79902,6667,3156,5058,3612,993,6237,3845,364,8772,1956,7175,1647,10111,472,23613,57178,55671,196	CYP19A1,MAX,TSC2,MTOR,SMARCA4,PIGR,BID,BARD1,CCND1,PIAS1,WEE1,CTNNB1,CDH1,NFKB1,PIK3R2,CDC25B,RASGEF1A,MYT1,UBE2F,PLK3,BAK1,FER,AKT1,GSK3A,RPP38,CDK4,BRCA1,VEGFA,DAG1,USP21,RHEB,RALA,SMAD2,EDAR,HIPK2,DHTKD1,XRCC3,BMPR1A,SMAD4,CSNK1D,USP15,PHB,CERK,SMAD7,TGFBR1,CHEK1,RAD54L,BLM,TGFBR2,JAKMIP1,JUN,ABL1,NOXA1,MYC,USP38,SELK,ATR,CREB1,SMAD6,NUP85,SP1,HMGCR,PAK1,IMPA1,CDC25A,RRAS,KRAS,AQP7,FADD,EGFR,TPR,GADD45A,RAD50,ATM,ZMYND8,ZMIZ1,SMEK1,AHR
WP399	Wnt Signaling Pathway and Pluripotency	0.227079232070327	-1.48245628244362	101	52	0.0243788091889358	2133	4508	8325,100500905,7472,11211,3949,85409,51701,324,1488,5578,8323,5583,595,3725,1499,5518,4609,80326,896,5580,5601,5521,960,6885,89780,7484,1856,8321,28227,1454,7476,7481,7477,6932,6934,5515,2103,5529,83439,4800,54361,7475,81029,8312,85407,5590,2932,1855,7855,5522,8061,1487	FZD8,MIR3661,WNT2,FZD10,LDLR,NKD2,NLK,APC,CTBP2,PRKCA,FZD6,PRKCH,CCND1,JUN,CTNNB1,PPP2R1A,MYC,WNT10A,CCND3,PRKCD,MAPK9,PPP2R2B,CD44,MAP3K7,WNT3A,WNT9B,DVL2,FZD1,PPP2R3B,CSNK1E,WNT7A,WNT11,WNT7B,TCF7,TCF7L2,PPP2CA,ESRRB,PPP2R5E,TCF7L1,NFYA,WNT4,WNT6,WNT5B,AXIN1,NKD1,PRKCZ,GSK3B,DVL1,FZD5,PPP2R2C,FOSL1,CTBP1
WP710	DNA damage response (only ATM dependent)	0.23246486168569	-1.45901619791106	91	47	0.0220346929207689	2133	4508	3146,7472,3949,2064,324,1026,100129518,5881,25,595,7161,3725,5880,6464,1499,5366,4609,80326,896,5601,4790,6885,4791,89780,1856,901,578,207,7476,7477,7481,4088,847,5529,54361,3643,7475,10000,81029,8312,356,472,2932,27113,1855,8061,4089	HMGB1,WNT2,LDLR,ERBB2,APC,CDKN1A,LOC100129518,RAC3,ABL1,CCND1,TP73,JUN,RAC2,SHC1,CTNNB1,PMAIP1,MYC,WNT10A,CCND3,MAPK9,NFKB1,MAP3K7,NFKB2,WNT3A,DVL2,CCNG2,BAK1,AKT1,WNT7A,WNT7B,WNT11,SMAD3,CAT,PPP2R5E,WNT4,INSR,WNT6,AKT3,WNT5B,AXIN1,FASLG,ATM,GSK3B,BBC3,DVL1,FOSL1,SMAD4
WP231	TNF-alpha/NF-kB Signaling Pathway	0.242935570537223	-1.41495901262002	196	98	0.0459446788560713	2133	4508	7189,23291,1540,5607,9462,943,6597,8737,10013,7531,7329,5566,8290,329,10914,6598,3551,10270,5701,4790,5134,5971,4791,2969,4215,207,330,5441,10318,3326,10971,57805,2316,857,7763,5515,10401,8517,3839,7185,23118,5709,10293,5590,7132,6500,2932,2289,6198,7187,5437,79155,9618,7188,3315,86,3066,7323,4794,1611,7186,100500905,1326,619571,5585,9252,6714,10788,8837,222643,6205,4174,10010,5781,3320,2091,9020,8792,283106,64425,9099,29110,7128,6132,3784,5747,10399,2011,8439,8772,9641,4792,2734,4163,7322,7534,10848,8945	TRAF6,FBXW11,CYLD,MAP2K5,RASAL2,TNFRSF8,SMARCA4,RIPK1,HDAC6,YWHAE,UBE2I,PRKACA,HIST3H3,BIRC2,PAPOLA,SMARCB1,IKBKB,AKAP8,PSMC2,NFKB1,PDCD2,RELB,NFKB2,GTF2I,MAP3K3,AKT1,BIRC3,POLR2L,TNIP1,HSP90AB1,YWHAQ,CCAR2,FLNA,CAV1,ZFAND5,PPP2CA,PIAS3,IKBKG,KPNA3,TRAF1,TAB2,PSMD3,TRAIP,PRKCZ,TNFRSF1A,SKP1,GSK3B,FKBP5,RPS6KB1,TRAF3,POLR2H,TNIP2,TRAF4,TRAF5,HSPB1,ACTL6A,HDAC2,UBE2D3,NFKBIE,DAP,TRAF2,MIR3661,MAP3K8,SNORD96A,PKN1,RPS6KA5,SRC,IQGAP2,CFLAR,UNC5CL,RPS11,MCM5,TANK,PTPN11,HSP90AA1,FBL,MAP3K14,TNFRSF11A,CSNK2A3,POLR1E,USP2,TBK1,TNFAIP3,RPL8,KCNQ1,PTK2,GNB2L1,MARK2,NSMAF,FADD,IKBKE,NFKBIA,GLG1,MCC,UBE2D2,YWHAZ,PPP1R13L,BTRC
WP734	Serotonin Receptor 4/6/7 and NR3C Signaling	0.243304297640044	-1.41344236539452	19	11	0.00515705578996718	2133	4508	3363,2005,9261,1958,2908,3362,6722,1385,3360,9252,5605	HTR7,ELK4,MAPKAPK2,EGR1,NR3C1,HTR6,SRF,CREB1,HTR4,RPS6KA5,MAP2K2
WP1742	TP53 network	0.243304297640044	-1.41344236539452	19	11	0.00515705578996718	2133	4508	25,7161,1647,5366,4609,8743,27113,472,1026,666,637	ABL1,TP73,GADD45A,PMAIP1,MYC,TNFSF10,BBC3,ATM,CDKN1A,BOK,BID
WP384	Apoptosis Modulation by HSP70	0.243304297640044	-1.41344236539452	19	11	0.00515705578996718	2133	4508	839,4790,7132,8737,54205,317,637,3303,8772,3304,355	CASP6,NFKB1,TNFRSF1A,RIPK1,CYCS,APAF1,BID,HSPA1A,FADD,HSPA1B,FAS
WP1602	Nicotine Activity on Dopaminergic Neurons	0.246497084055153	-1.40040511496022	21	12	0.00562587904360056	2133	4508	1020,51305,1137,1141,2782,8973,5499,3777,6571,5566,1815,1644	CDK5,KCNK9,CHRNA4,CHRNB2,GNB1,CHRNA6,PPP1CA,KCNK3,SLC18A2,PRKACA,DRD4,DDC
WP1422	Sphingolipid Metabolism	0.246497084055153	-1.40040511496022	21	12	0.00562587904360056	2133	4508	2531,8611,204219,91012,64781,8877,166929,79603,56848,9517,130367,29956	KDSR,PPAP2A,CERS3,CERS5,CERK,SPHK1,SGMS2,CERS4,SPHK2,SPTLC2,SGPP2,CERS2
WP558	Complement and Coagulation Cascades	0.251766962769915	-1.37925137022966	51	27	0.0126582278481013	2133	4508	2165,718,2147,5329,729,3053,336,1380,2153,733,5104,4179,713,2159,5265,712,1378,714,5624,7450,5054,5627,623,5345,2155,462,10747	F13B,C3,F2,PLAUR,C6,SERPIND1,APOA2,CR2,F5,C8G,SERPINA5,CD46,C1QB,F10,SERPINA1,C1QA,CR1,C1QC,PROC,VWF,SERPINE1,PROS1,BDKRB1,SERPINF2,F7,SERPINC1,MASP2
WP2100	AhR pathway	0.253242670108151	-1.37340707957665	29	16	0.00750117205813408	2133	4508	3280,1728,3484,1026,9049,6714,1956,57491,3725,218,54578,3320,2312,405,196,4780	HES1,NQO1,IGFBP1,CDKN1A,AIP,SRC,EGFR,AHRR,JUN,ALDH3A1,UGT1A6,HSP90AA1,FLG,ARNT,AHR,NFE2L2
WP28	Selenium Metabolism and Selenoproteins	0.254011037378288	-1.37037755866248	43	23	0.0107829348335677	2133	4508	7296,85465,54952,2878,1735,83642,2353,54938,8991,3725,60678,4790,140606,58515,51714,2876,2168,4780,57190,6667,51540,2879,1491	TXNRD1,EPT1,TRNAU1AP,GPX3,DIO3,SELO,FOS,SARS2,SELENBP1,JUN,EEFSEC,NFKB1,SELM,SELK,SELT,GPX1,FABP1,NFE2L2,SEPN1,SP1,SCLY,GPX4,CTH
WP2263	Prostate Cancer	0.284670783815774	-1.2564219109132	109	55	0.0257852789498359	2133	4508	3292,253314,7249,1793,2475,5894,10397,6597,1111,51478,641,1432,580,57492,3817,595,1399,57521,3725,10811,4609,5781,5290,545,994,6774,10253,6667,5058,2165,993,2889,5829,207,10257,5591,1019,3294,3295,672,2353,5605,983,6009,4088,4087,1978,10111,472,2185,2289,3082,6603,3265,86	HSD17B1,EIF4E1B,TSC2,DOCK1,MTOR,RAF1,NDRG1,SMARCA4,CHEK1,HSD17B7,BLM,MAPK14,BARD1,ARID1B,KLK2,CCND1,CRKL,RPTOR,JUN,NOXA1,MYC,PTPN11,PIK3CA,ATR,CDC25B,STAT3,SPRY2,SP1,PAK1,F13B,CDC25A,RAPGEF1,PXN,AKT1,ABCC4,PRKDC,CDK4,HSD17B2,HSD17B4,BRCA1,FOS,MAP2K2,CDK1,RHEB,SMAD3,SMAD2,EIF4EBP1,RAD50,ATM,PTK2B,FKBP5,HGF,SMARCD2,HRAS,ACTL6A
WP1981	Thyroxine (Thyroid Hormone) Production	0.294742159043149	-1.22165434197737	6	4	0.00187529301453352	2133	4508	7038,7200,7173,6528	TG,TRH,TPO,SLC5A5
WP410	Diurnally regulated genes with circadian orthologs	0.299490314833437	-1.20567319973436	50	26	0.0121894045944679	2133	4508	7122,7360,3312,6612,2950,1982,5685,51663,5281,9709,8864,1051,694,3422,23118,5187,50486,406,9218,51582,1408,687,11030,5813,10140,10381	CLDN5,UGP2,HSPA8,SUMO3,GSTP1,EIF4G2,PSMA4,ZFR,PIGF,HERPUD1,PER2,CEBPB,BTG1,IDI1,TAB2,PER1,G0S2,ARNTL,VAPA,AZIN1,CRY2,KLF9,RBPMS,PURA,TOB1,TUBB3
WP237	Glucocorticoid & Mineralcorticoid Metabolism	0.306147517395401	-1.18368821020292	8	5	0.0023441162681669	2133	4508	1583,1589,3290,3291,1585	CYP11A1,CYP21A2,HSD11B1,HSD11B2,CYP11B2
WP49	IL-2 Signaling pathway	0.30622399377104	-1.18343843902761	42	22	0.0103141115799344	2133	4508	207,5894,5295,3560,867,2353,5605,9021,3725,1399,1154,2534,6464,4609,5781,2185,6776,6198,6774,3265,6850,6199	AKT1,RAF1,PIK3R1,IL2RB,CBL,FOS,MAP2K2,SOCS3,JUN,CRKL,CISH,FYN,SHC1,MYC,PTPN11,PTK2B,STAT5A,RPS6KB1,STAT3,HRAS,SYK,RPS6KB2
WP106	Alanine and aspartate metabolism	0.316608075475364	-1.1500906249895	12	7	0.00328176277543366	2133	4508	445,189,2805,5091,2875,1615,435	ASS1,AGXT,GOT1,PC,GPT,DARS,ASL
WP12	Osteoclast Signaling	0.319985057752098	-1.13948097880328	16	9	0.00421940928270042	2133	4508	56302,6548,4982,3454,8111,1513,7965,8792,9550	TRPV5,SLC9A1,TNFRSF11B,IFNAR1,GPR68,CTSK,AIMP2,TNFRSF11A,ATP6V1G1
WP2359	Parkin-Ubiquitin Proteasomal System pathway	0.360082987954405	-1.02142075200255	76	38	0.0178152836380684	2133	4508	5071,7280,7317,10383,2812,84617,3303,898,51182,6477,5701,10213,7326,55294,25897,347688,3306,7327,10381,7277,3312,3309,3311,118424,5710,112714,3304,10376,3310,5704,3313,3308,7278,5709,5714,51807,6478,9627	PARK2,TUBB2A,UBA1,TUBB4B,GP1BB,TUBB6,HSPA1A,CCNE1,HSPA14,SIAH1,PSMC2,PSMD14,UBE2G1,FBXW7,RNF19A,TUBB8,HSPA2,UBE2G2,TUBB3,TUBA4A,HSPA8,HSPA5,HSPA7,UBE2J2,PSMD4,TUBA3E,HSPA1B,TUBA1B,HSPA6,PSMC4,HSPA9,HSPA4,TUBA3C,PSMD3,PSMD8,TUBA8,SIAH2,SNCAIP
WP2118	Arrhythmogenic right ventricular cardiomyopathy	0.363028746012426	-1.01327325773578	74	37	0.0173464603844351	2133	4508	3728,71,1495,3655,6444,9254,5318,88,4000,786,1499,3696,3675,2010,1829,22801,779,3672,8515,3694,10369,27092,6262,87,6932,93589,1832,1605,6934,83439,3688,81,60,784,3685,3691,1000	JUP,ACTG1,CTNNA1,ITGA6,SGCD,CACNA2D2,PKP2,ACTN2,LMNA,CACNG1,CTNNB1,ITGB8,ITGA3,EMD,DSG2,ITGA11,CACNA1S,ITGA1,ITGA10,ITGB6,CACNG2,CACNG4,RYR2,ACTN1,TCF7,CACNA2D4,DSP,DAG1,TCF7L2,TCF7L1,ITGB1,ACTN4,ACTB,CACNB3,ITGAV,ITGB4,CDH2
WP2371	Parkinsons Disease Pathway	0.367274626458671	-1.00164540978785	39	20	0.00937646507266761	2133	4508	9134,5071,7317,839,6531,2812,54205,118424,1432,11315,898,2058,5600,7326,23208,317,9627,7327,1644,6300	CCNE2,PARK2,UBA1,CASP6,SLC6A3,GP1BB,CYCS,UBE2J2,MAPK14,PARK7,CCNE1,EPRS,MAPK11,UBE2G1,SYT11,APAF1,SNCAIP,UBE2G2,DDC,MAPK12
WP2525	Trans-sulfuration and one carbon metabolism	0.381120845825462	-0.964638773502325	31	16	0.00750117205813408	2133	4508	6470,1788,29947,29968,875,25902,275,4548,23382,27430,10797,191,10768,441024,5723,1491	SHMT1,DNMT3A,DNMT3L,PSAT1,CBS,MTHFD1L,AMT,MTR,AHCYL2,MAT2B,MTHFD2,AHCY,AHCYL1,MTHFD2L,PSPH,CTH
WP422	MAPK Cascade	0.384870524059148	-0.954848302401336	29	15	0.0070323488045007	2133	4508	4215,3725,4155,5609,6237,4133,5894,22821,3845,1432,3265,5605,5606,6300,5331	MAP3K3,JUN,MBP,MAP2K7,RRAS,MAP2,RAF1,RASA3,KRAS,MAPK14,HRAS,MAP2K2,MAP2K3,MAPK12,PLCB3
WP706	SIDS Susceptibility Pathways	0.385739174226598	-0.952593852354068	160	78	0.0365682137834037	2133	4508	4152,133522,3596,5979,5087,2625,7531,5566,6095,9722,7161,1499,4790,1889,3557,4791,23171,5567,11076,1139,2597,8929,10971,5577,3586,3757,7422,406992,2554,4800,2645,291,4133,3576,226,4128,388585,1746,30012,4208,7433,1958,6929,1141,10664,401,859,8553,9734,3725,2019,4904,4150,1385,5316,2328,1644,6667,3280,2908,5575,2902,6262,864,3784,3570,1051,1137,3091,1103,6550,4010,7534,4915,7434,55800,117,478	MBD1,PPARGC1B,IL13,RET,PBX1,GATA3,YWHAE,PRKACA,RORA,NOS1AP,TP73,CTNNB1,NFKB1,ECE1,IL1RN,NFKB2,GPD1L,PRKACB,TPPP,CHRNA7,GAPDH,PHOX2B,YWHAQ,PRKAR2B,IL10,KCNH2,VEGFA,MIR210,GABRA1,NFYA,GCK,SLC25A4,MAP2,IL8,ALDOA,MAOA,HES5,DLX2,TLX3,MEF2C,VIPR1,EGR1,TCF3,CHRNB2,CTCF,PHOX2A,CAV3,BHLHE40,HDAC9,JUN,EN1,YBX1,MAZ,CREB1,PKNOX1,FMO3,DDC,SP1,HES1,NR3C1,PRKAR1B,GRIN1,RYR2,RUNX3,KCNQ1,IL6R,CEBPB,CHRNA4,HIF1A,CHAT,SLC9A3,LMX1B,YWHAZ,NTRK2,VIPR2,SCN3B,ADCYAP1R1,ATP1A3
WP1038	Vitamin A and Carotenoid Metabolism	0.392799044776082	-0.934457134337569	25	13	0.00609470229723394	2133	4508	56603,6258,5914,29881,5959,6256,157506,220,6017,949,948,6820,1592	CYP26B1,RXRG,RARA,NPC1L1,RDH5,RXRA,RDH10,ALDH1A3,RLBP1,SCARB1,CD36,SULT2B1,CYP26A1
WP1584	Type II diabetes mellitus	0.401415820272451	-0.912757430660012	21	11	0.00515705578996718	2133	4508	3643,3651,2475,23533,773,5580,3551,5590,389692,3767,723961	INSR,PDX1,MTOR,PIK3R5,CACNA1A,PRKCD,IKBKB,PRKCZ,MAFA,KCNJ11,INS-IGF2
WP1541	Energy Metabolism	0.408583521540856	-0.89505892648465	48	24	0.0112517580872011	2133	4508	5563,5564,51106,64216,2551,133522,5565,6256,5562,3276,4205,4209,1432,53632,10514,51422,2932,5533,23082,2101,1385,1386,818,4208	PRKAA2,PRKAB1,TFB1M,TFB2M,GABPA,PPARGC1B,PRKAB2,RXRA,PRKAA1,PRMT1,MEF2A,MEF2D,MAPK14,PRKAG3,MYBBP1A,PRKAG2,GSK3B,PPP3CC,PPRC1,ESRRA,CREB1,ATF2,CAMK2G,MEF2C
WP732	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling	0.410920184532454	-0.889356281562691	17	9	0.00421940928270042	2133	4508	2005,9261,5923,2626,3358,5894,3708,6722,5605	ELK4,MAPKAPK2,RASGRF1,GATA4,HTR2C,RAF1,ITPR1,SRF,MAP2K2
WP501	GPCRs, Class C Metabotropic glutamate, pheromone	0.416098137627871	-0.876834138783428	15	8	0.00375058602906704	2133	4508	2914,2916,9052,2913,846,2917,9568,2912	GRM4,GRM6,GPRC5A,GRM3,CASR,GRM7,GABBR2,GRM2
WP466	DNA Replication	0.421890195779387	-0.86301019837882	42	21	0.00984528832630099	2133	4508	55388,5983,4999,7311,5558,81620,10926,990,4171,5424,7316,6118,4173,5111,5426,4174,29935,5981,57804,5425,4172	MCM10,RFC3,ORC2,UBA52,PRIM2,CDT1,DBF4,CDC6,MCM2,POLD1,UBC,RPA2,MCM4,PCNA,POLE,MCM5,RPA4,RFC1,POLD4,POLD2,MCM3
WP1423	Ganglio Sphingolipid Metabolism	0.42760830961804	-0.84954766686282	11	6	0.00281293952180028	2133	4508	6483,6489,6482,8705,2523,9197	ST3GAL2,ST8SIA1,ST3GAL1,B3GALT4,FUT1,SLC33A1
WP80	Nucleotide GPCRs	0.42760830961804	-0.84954766686282	11	6	0.00281293952180028	2133	4508	136,5028,134,1241,10161,5029	ADORA2B,P2RY1,ADORA1,LTB4R,LPAR6,P2RY2
WP383	Striated Muscle Contraction	0.431675445518545	-0.840081256614806	38	19	0.00890764181903422	2133	4508	7140,7134,7136,7125,7169,7170,71,7171,7431,88,7135,4607,58,4621,81,8557,7139,7168,4634	TNNT3,TNNC1,TNNI2,TNNC2,TPM2,TPM3,ACTG1,TPM4,VIM,ACTN2,TNNI1,MYBPC3,ACTA1,MYH3,ACTN4,TCAP,TNNT2,TPM1,MYL3
WP314	FAS pathway and Stress induction of HSP regulation	0.431675445518545	-0.840081256614806	38	19	0.00890764181903422	2133	4508	5058,1677,142,839,7867,5591,54205,8772,4000,8837,355,3725,9261,4001,1616,356,317,6885,3315	PAK1,DFFB,PARP1,CASP6,MAPKAPK3,PRKDC,CYCS,FADD,LMNA,CFLAR,FAS,JUN,MAPKAPK2,LMNB1,DAXX,FASLG,APAF1,MAP3K7,HSPB1
WP531	Mismatch repair	0.434140679213068	-0.834386651753353	9	5	0.0023441162681669	2133	4508	9156,3978,5981,5111,5424	EXO1,LIG1,RFC1,PCNA,POLD1
WP2261	Signaling Pathways in Glioblastoma	0.441161935083975	-0.818343271199711	80	39	0.0182841068917018	2133	4508	5607,7249,5894,4194,2064,1026,5578,6714,898,5606,5583,595,5580,5336,5296,5290,2065,4233,54206,10253,5159,5170,207,5609,1019,5295,3845,672,867,5605,2260,5286,1956,5335,10000,5590,472,5287,3265	MAP2K5,TSC2,RAF1,MDM4,ERBB2,CDKN1A,PRKCA,SRC,CCNE1,MAP2K3,PRKCH,CCND1,PRKCD,PLCG2,PIK3R2,PIK3CA,ERBB3,MET,ERRFI1,SPRY2,PDGFRB,PDPK1,AKT1,MAP2K7,CDK4,PIK3R1,KRAS,BRCA1,CBL,MAP2K2,FGFR1,PIK3C2A,EGFR,PLCG1,AKT3,PRKCZ,ATM,PIK3C2B,HRAS
WP2406	Cardiac Progenitor Differentiation	0.452569503398522	-0.792813928966458	53	26	0.0121894045944679	2133	4508	4851,91807,2626,50805,1482,1432,140885,3630,22943,290,7070,6862,3170,132625,83881,9241,649,145873,2932,7139,3084,55897,89780,64321,3815,4208	NOTCH1,MYLK3,GATA4,IRX4,NKX2-5,MAPK14,SIRPA,INS,DKK1,ANPEP,THY1,T,FOXA2,ZFP42,MIXL1,NOG,BMP1,MESP2,GSK3B,TNNT2,NRG1,MESP1,WNT3A,SOX17,KIT,MEF2C
WP2267	Synaptic Vesicle Pathway	0.457654740354021	-0.781640221171515	51	25	0.0117205813408345	2133	4508	2054,26052,6581,81539,8224,773,112755,11315,161,291,10059,6804,160,23025,5864,1785,10814,10815,1211,774,6571,2055,8775,477,594855	STX2,DNM3,SLC22A3,SLC38A1,SYN3,CACNA1A,STX1B,PARK7,AP2A2,SLC25A4,DNM1L,STX1A,AP2A1,UNC13A,RAB3A,DNM2,CPLX2,CPLX1,CLTA,CACNA1B,SLC18A2,CLN8,NAPA,ATP1A2,CPLX3
WP534	Glycolysis and Gluconeogenesis	0.462931049698156	-0.770177156724021	49	24	0.0112517580872011	2133	4508	5160,2597,5313,6513,3939,5161,5315,51660,92483,25874,5091,2645,5230,5211,226,5105,3099,5224,2805,3098,2821,2023,3101,3945	PDHA1,GAPDH,PKLR,SLC2A1,LDHA,PDHA2,PKM,MPC1,LDHAL6B,MPC2,PC,GCK,PGK1,PFKL,ALDOA,PCK1,HK2,PGAM2,GOT1,HK1,GPI,ENO1,HK3,LDHB
WP581	EPO Receptor Signaling	0.467637263362317	-0.76006236187861	26	13	0.00609470229723394	2133	4508	5788,1154,207,6464,8651,2057,10076,5894,6776,3717,6774,5605,6714	PTPRC,CISH,AKT1,SHC1,SOCS1,EPOR,PTPRU,RAF1,STAT5A,JAK2,STAT3,MAP2K2,SRC
WP2446	RB in Cancer	0.470315771703571	-0.754350955182907	87	42	0.019690576652602	2133	4508	9134,3146,5894,81620,1111,1026,25942,891,3925,580,898,4173,25,6118,595,7465,5111,4609,896,10733,994,6595,993,5983,5591,1019,1871,6241,5877,10592,3275,2189,983,5426,8030,1633,7027,8243,3148,7029,1870,4172	CCNE2,HMGB1,RAF1,CDT1,CHEK1,CDKN1A,SIN3A,CCNB1,STMN1,BARD1,CCNE1,MCM4,ABL1,RPA2,CCND1,WEE1,PCNA,MYC,CCND3,PLK4,CDC25B,SMARCA2,CDC25A,RFC3,PRKDC,CDK4,E2F3,RRM2,RABIF,SMC2,PRMT2,FANCG,CDK1,POLE,CCDC6,DCK,TFDP1,SMC1A,HMGB2,TFDP2,E2F2,MCM3
WP1946	Cori Cycle	0.473158828750816	-0.748324156684248	1	1	0.00046882325363338	2133	4508	3098	HK1
WP22	IL-9 Signaling Pathway	0.475052633479193	-0.744329673761557	24	12	0.00562587904360056	2133	4508	207,6464,5295,5781,6776,3578,6774,3581,5605,7297,7415,9021	AKT1,SHC1,PIK3R1,PTPN11,STAT5A,IL9,STAT3,IL9R,MAP2K2,TYK2,VCP,SOCS3
WP1528	Physiological and Pathological Hypertrophy  of the Heart	0.475052633479193	-0.744329673761557	24	12	0.00562587904360056	2133	4508	3725,817,2626,183,3572,1906,5600,4776,2353,1432,6774,5606	JUN,CAMK2D,GATA4,AGT,IL6ST,EDN1,MAPK11,NFATC4,FOS,MAPK14,STAT3,MAP2K3
WP26	Signal Transduction of S1P Receptor	0.475052633479193	-0.744329673761557	24	12	0.00562587904360056	2133	4508	207,53637,10000,1903,8877,5287,5596,56848,5330,2771,6300,5331	AKT1,S1PR5,AKT3,S1PR3,SPHK1,PIK3C2B,MAPK4,SPHK2,PLCB2,GNAI2,MAPK12,PLCB3
WP254	Apoptosis	0.479096982257712	-0.735852233886198	83	40	0.0187529301453352	2133	4508	1677,4794,839,7186,27242,8737,54205,3661,8718,637,329,8837,7161,3725,3662,5366,4609,3551,4790,5551,578,330,207,5295,8743,4170,3664,8772,355,8517,7185,4792,7132,356,27113,7187,3665,317,666,3659	DFFB,NFKBIE,CASP6,TRAF2,TNFRSF21,RIPK1,CYCS,IRF3,TNFRSF25,BID,BIRC2,CFLAR,TP73,JUN,IRF4,PMAIP1,MYC,IKBKB,NFKB1,PRF1,BAK1,BIRC3,AKT1,PIK3R1,TNFSF10,MCL1,IRF6,FADD,FAS,IKBKG,TRAF1,NFKBIA,TNFRSF1A,FASLG,BBC3,TRAF3,IRF7,APAF1,BOK,IRF1
WP2034	Leptin signaling pathway	0.487635282843965	-0.718187523771474	60	29	0.013595874355368	2133	4508	207,2475,5894,5295,8835,2064,1432,6714,5605,9021,595,1154,5335,8517,5770,2534,6464,3551,4790,5296,5781,3717,3952,6198,3557,1385,6774,3265,6667	AKT1,MTOR,RAF1,PIK3R1,SOCS2,ERBB2,MAPK14,SRC,MAP2K2,SOCS3,CCND1,CISH,PLCG1,IKBKG,PTPN1,FYN,SHC1,IKBKB,NFKB1,PIK3R2,PTPN11,JAK2,LEP,RPS6KB1,IL1RN,CREB1,STAT3,HRAS,SP1
WP411	mRNA processing	0.488957098080711	-0.715480527342392	136	65	0.0304735114861697	2133	4508	3182,10978,56853,1659,6635,83443,10992,10914,29894,6632,6427,84844,6434,3191,3192,1653,1477,6421,58155,5725,6433,6628,3183,10921,9129,10907,10421,6426,57794,10262,1198,10236,100302196,8243,9128,2521,100126351,9785,8106,8899,6627,3178,10659,1195,6431,10250,3276,1660,3187,56339,57396,3184,4904,10658,10898,55660,1196,10147,3275,8175,23405,1478,22916,6625,9584	HNRNPAB,CLP1,CELF4,DHX8,SNRPE,SF3B5,SF3B2,PAPOLA,CPSF1,SNRPD1,SRSF2,PHF5A,TRA2B,HNRNPL,HNRNPU,DDX1,CSTF1,SFPQ,PTBP2,PTBP1,SFSWAP,SNRPB,HNRNPC,RNPS1,PRPF3,TXNL4A,CD2BP2,SRSF1,SUGP1,SF3B4,CLK3,HNRNPR,MIR1234,SMC1A,PRPF4,FUS,MIR939,DHX38,PABPN1,PRPF4B,SNRPA1,HNRNPA1,CELF2,CLK1,SRSF6,SRRM1,PRMT1,DHX9,HNRNPH1,METTL3,CLK4,HNRNPD,YBX1,CELF1,CPSF4,PRPF40A,CLK2,SUGP2,PRMT2,SF3A2,DICER1,CSTF2,NCBP2,SNRNP70,RBM39
WP497	Urea cycle and metabolism of amino groups	0.491813750486562	-0.709655190081831	20	10	0.0046882325363338	2133	4508	384,6723,95,65263,2593,435,445,1152,4942,4953	ARG2,SRM,ACY1,PYCRL,GAMT,ASL,ASS1,CKB,OAT,ODC1
WP500	Glycogen Metabolism	0.49973021175585	-0.693686902672025	37	18	0.00843881856540084	2133	4508	2632,5236,28227,2931,7360,100500905,5257,5834,5515,5529,5525,5518,2932,2997,5521,5522,5261,5528	GBE1,PGM1,PPP2R3B,GSK3A,UGP2,MIR3661,PHKB,PYGB,PPP2CA,PPP2R5E,PPP2R5A,PPP2R1A,GSK3B,GYS1,PPP2R2B,PPP2R2C,PHKG2,PPP2R5D
WP2011	SREBF and miR33 in cholesterol and lipid homeostasis	0.501450345256814	-0.690250688931228	18	9	0.00421940928270042	2133	4508	693120,3157,2475,51586,5562,3949,2194,3156,6720	MIR33B,HMGCS1,MTOR,MED15,PRKAA1,LDLR,FASN,HMGCR,SREBF1
WP2291	Deregulation of Rab and Rab Effector Genes in Bladder Cancer	0.512211217507032	-0.669018204818043	16	8	0.00375058602906704	2133	4508	201294,9648,79083,9501,83874,84958,5874,94120	UNC13D,GCC2,MLPH,RPH3AL,TBC1D10A,SYTL1,RAB27B,SYTL3
WP35	G Protein Signaling Pathways	0.536502997650524	-0.622683129507564	95	45	0.0210970464135021	2133	4508	2769,2774,5137,2782,5578,5566,5143,2783,5331,5583,9472,5136,2781,2793,5580,9138,10270,109,6548,112,51764,5144,2771,5567,113,6237,2788,5575,107,2786,9590,5577,5151,3845,11214,2767,9630,8165,2768,111,114,3708,5590,5533,3265	GNA15,GNAL,PDE1C,GNB1,PRKCA,PRKACA,PDE4C,GNB2,PLCB3,PRKCH,AKAP6,PDE1A,GNAZ,GNGT2,PRKCD,ARHGEF1,AKAP8,ADCY3,SLC9A1,ADCY6,GNG13,PDE4D,GNAI2,PRKACB,ADCY7,RRAS,GNG7,PRKAR1B,ADCY1,GNG4,AKAP12,PRKAR2B,PDE8A,KRAS,AKAP13,GNA11,GNA14,AKAP1,GNA12,ADCY5,ADCY8,ITPR1,PRKCZ,PPP3CC,HRAS
WP195	IL-1 Signaling Pathway	0.538608543766113	-0.618766235815279	12	6	0.00281293952180028	2133	4508	3554,7189,3557,3654,3556,140885	IL1R1,TRAF6,IL1RN,IRAK1,IL1RAP,SIRPA
WP2361	Gastric cancer network 1	0.544891594697043	-0.60716841291664	42	20	0.00937646507266761	2133	4508	4851,8370,1063,1894,22974,4605,3021,9585,324,64094,54891,286826,4173,8607,352954,55125,3020,11065,86,8209	NOTCH1,HIST2H4A,CENPF,ECT2,TPX2,MYBL2,H3F3B,KIF20B,APC,SMOC2,INO80D,LIN9,MCM4,RUVBL1,GATS,CEP192,H3F3A,UBE2C,ACTL6A,C21orf33
WP2012	miRs in Muscle Cell Differentiation	0.544891594697043	-0.60716841291664	42	20	0.00937646507266761	2133	4508	5575,3398,4205,5577,4209,5081,5578,407007,407006,5566,5583,406923,5580,5590,4654,6722,100422882,5567,4208,407015	PRKAR1B,ID2,MEF2A,PRKAR2B,MEF2D,PAX7,PRKCA,MIR222,MIR221,PRKACA,PRKCH,MIR133A2,PRKCD,PRKCZ,MYOD1,SRF,MIR3120,PRKACB,MEF2C,MIR26A1
WP496	Steroid Biosynthesis	0.555556375139655	-0.587785189651828	10	5	0.0023441162681669	2133	4508	2165,3292,51478,3295,3294	F13B,HSD17B1,HSD17B7,HSD17B4,HSD17B2
WP170	Nuclear Receptors	0.560979501376413	-0.578070913563005	38	18	0.00843881856540084	2133	4508	6097,6258,5914,2908,3164,7067,6256,2494,6095,7101,2103,7421,2516,9970,4929,7026,2101,3172	RORC,RXRG,RARA,NR3C1,NR4A1,THRA,RXRA,NR5A2,RORA,NR2E1,ESRRB,VDR,NR5A1,NR1I3,NR4A2,NR2F2,ESRRA,HNF4A
WP1539	Angiogenesis	0.561957697505633	-0.576328703263765	23	11	0.00515705578996718	2133	4508	4318,5335,207,3091,2321,5290,5747,7422,6714,284,405	MMP9,PLCG1,AKT1,HIF1A,FLT1,PIK3CA,PTK2,VEGFA,SRC,ANGPT1,ARNT
WP1531	Vitamin D synthesis	0.57668261752002	-0.550463220101623	8	4	0.00187529301453352	2133	4508	7421,1591,6256,120227	VDR,CYP24A1,RXRA,CYP2R1
WP288	NLR proteins	0.57668261752002	-0.550463220101623	8	4	0.00187529301453352	2133	4508	8517,6885,2048,3551	IKBKG,MAP3K7,EPHB2,IKBKB
WP1544	MicroRNAs in cardiomyocyte hypertrophy	0.581955749600636	-0.541360865755277	109	51	0.0239099859353024	2133	4508	407010,5607,2475,5894,5596,1432,5606,9734,1154,406923,1499,3572,51564,3551,5296,4790,406971,5290,8503,9020,89780,406961,6774,5330,406911,8321,5170,3976,91807,5609,207,2626,5295,1906,406991,5605,406976,817,8517,9641,9759,183,1025,4638,2932,3084,4776,100422882,1855,6093,406884	MIR23A,MAP2K5,MTOR,RAF1,MAPK4,MAPK14,MAP2K3,HDAC9,CISH,MIR133A2,CTNNB1,IL6ST,HDAC7,IKBKB,PIK3R2,NFKB1,MIR195,PIK3CA,PIK3R3,MAP3K14,WNT3A,MIR185,STAT3,PLCB2,MIR125B1,FZD1,PDPK1,LIF,MYLK3,MAP2K7,AKT1,GATA4,PIK3R1,EDN1,MIR21,MAP2K2,MIR199A1,CAMK2D,IKBKG,IKBKE,HDAC4,AGT,CDK9,MYLK,GSK3B,NRG1,NFATC4,MIR3120,DVL1,ROCK1,MIRLET7B
WP453	Inflammatory Response Pathway	0.588697174626201	-0.529843362303414	32	15	0.0070323488045007	2133	4508	3915,2335,7448,942,1277,3565,7132,3913,3566,7059,3560,3911,940,3918,3567	LAMC1,FN1,VTN,CD86,COL1A1,IL4,TNFRSF1A,LAMB2,IL4R,THBS3,IL2RB,LAMA5,CD28,LAMC2,IL5
WP430	Statin Pathway	0.588697174626201	-0.529843362303414	32	15	0.0070323488045007	2133	4508	6646,3931,4547,64714,341,3949,336,693120,6713,949,8694,3990,84532,3156,2222	SOAT1,LCAT,MTTP,PDIA2,APOC1,LDLR,APOA2,MIR33B,SQLE,SCARB1,DGAT1,LIPC,ACSS1,HMGCR,FDFT1
WP438	Non-homologous end joining	0.604752221806583	-0.502936455573023	6	3	0.00140646976090014	2133	4508	79840,10111,7520	NHEJ1,RAD50,XRCC5
WP176	Folate Metabolism	0.635492751684333	-0.453354594107158	24	11	0.00515705578996718	2133	4508	847,6647,2878,55312,191,949,4791,4353,2876,3630,2879	CAT,SOD1,GPX3,RFK,AHCY,SCARB1,NFKB2,MPO,GPX1,INS,GPX4
WP733	Serotonin Receptor 2 and STAT3 Signaling	0.646271166856938	-0.436536100338913	4	2	0.00093764650726676	2133	4508	3717,6774	JAK2,STAT3
WP357	Fatty Acid Biosynthesis	0.649763332139208	-0.431147086795774	22	10	0.0046882325363338	2133	4508	51703,1666,2180,3033,5091,55902,2181,23305,47,2194	ACSL5,DECR1,ACSL1,HADH,PC,ACSS2,ACSL3,ACSL6,ACLY,FASN
WP205	IL-7 Signaling Pathway	0.654429301341889	-0.423991718806816	44	20	0.00937646507266761	2133	4508	207,5894,1019,5295,868,4170,867,4067,5605,640,4582,2534,6464,10254,2185,2932,6776,6774,3265,3659	AKT1,RAF1,CDK4,PIK3R1,CBLB,MCL1,CBL,LYN,MAP2K2,BLK,MUC1,FYN,SHC1,STAM2,PTK2B,GSK3B,STAT5A,STAT3,HRAS,IRF1
WP404	Nucleotide Metabolism	0.665459492139319	-0.407277511310086	20	9	0.00421940928270042	2133	4508	159,6723,10797,50484,5428,6303,6241,3614,5424	ADSS,SRM,MTHFD2,RRM2B,POLG,SAT1,RRM2,IMPDH1,POLD1
WP716	Vitamin A and carotenoid metabolism	0.673894765193226	-0.394681314988277	40	18	0.00843881856540084	2133	4508	56603,6258,5914,29881,157506,6256,6017,5948,1382,948,9249,9227,1592,54884,220,5959,949,6820	CYP26B1,RXRG,RARA,NPC1L1,RDH10,RXRA,RLBP1,RBP2,CRABP2,CD36,DHRS3,LRAT,CYP26A1,RETSAT,ALDH1A3,RDH5,SCARB1,SULT2B1
WP524	G13 Signaling Pathway	0.673894765193226	-0.394681314988277	40	18	0.00843881856540084	2133	4508	398,10188,11113,5585,1729,5305,10788,4608,7454,57630,5216,3984,5296,9138,5290,6198,6093,1072	ARHGDIG,TNK2,CIT,PKN1,DIAPH1,PIP4K2A,IQGAP2,MYBPH,WAS,SH3RF1,PFN1,LIMK1,PIK3R2,ARHGEF1,PIK3CA,RPS6KB1,ROCK1,CFL1
WP241	One Carbon Metabolism	0.674386432439724	-0.3939519904688	29	13	0.00609470229723394	2133	4508	27430,10841,2618,10797,1788,6470,10588,471,191,25902,4548,275,23382	MAT2B,FTCD,GART,MTHFD2,DNMT3A,SHMT1,MTHFS,ATIC,AHCY,MTHFD1L,MTR,AMT,AHCYL2
WP15	Selenium Pathway	0.676950907931789	-0.39015652283239	88	40	0.0187529301453352	2133	4508	2678,2878,1735,3949,875,100129518,4353,3383,240,80308,8564,4790,5742,51714,58515,4791,1491,2879,7296,55163,2147,85465,6647,55312,83642,7001,4548,5052,3630,847,5743,3643,8942,12,140606,5054,949,2155,2876,57190	GGT1,GPX3,DIO3,LDLR,CBS,LOC100129518,MPO,ICAM1,ALOX5,FLAD1,KMO,NFKB1,PTGS1,SELT,SELK,NFKB2,CTH,GPX4,TXNRD1,PNPO,F2,EPT1,SOD1,RFK,SELO,PRDX2,MTR,PRDX1,INS,CAT,PTGS2,INSR,KYNU,SERPINA3,SELM,SERPINE1,SCARB1,F7,GPX1,SEPN1
WP561	Heme Biosynthesis	0.690716168172342	-0.37002629477499	9	4	0.00187529301453352	2133	4508	3145,210,7390,5498	HMBS,ALAD,UROS,PPOX
WP2363	Gastric cancer network 2	0.706838133587013	-0.346953587548551	34	15	0.0070323488045007	2133	4508	1299,5983,25909,29028,1499,29089,255488,4609,79075,27101,157769,11065,3930,6277,1956	COL9A3,RFC3,AHCTF1,ATAD2,CTNNB1,UBE2T,RNF144B,MYC,DSCC1,CACYBP,FAM91A1,UBE2C,LBR,S100A6,EGFR
WP2447	Amyotrophic lateral sclerosis (ALS)	0.706838133587013	-0.346953587548551	34	15	0.0070323488045007	2133	4508	847,79139,2890,6647,1616,7132,5533,5868,317,4217,1432,637,2876,5605,5630	CAT,DERL1,GRIA1,SOD1,DAXX,TNFRSF1A,PPP3CC,RAB5A,APAF1,MAP3K5,MAPK14,BID,GPX1,MAP2K2,PRPH
WP2526	PDGF Pathway	0.722493689686428	-0.325046593031715	2	1	0.00046882325363338	2133	4508	5154	PDGFA
WP1495	Glycine Metabolism	0.722493689686428	-0.325046593031715	2	1	0.00046882325363338	2133	4508	6470	SHMT1
WP186	Homologous recombination	0.724705130052014	-0.32199042402896	14	6	0.00281293952180028	2133	4508	472,5893,5424,57804,10111,5425	ATM,RAD52,POLD1,POLD4,RAD50,POLD2
WP678	Arachidonate Epoxygenase / Epoxide Hydrolase	0.7272550875602	-0.318477986017407	7	3	0.00140646976090014	2133	4508	9377,2950,1351	COX5A,GSTP1,COX8A
WP2431	Spinal Cord Injury	0.748065331697518	-0.290264962980135	112	50	0.023441162681669	2133	4508	4318,1948,50515,1958,6403,389,6662,3565,5362,358,6586,57142,63827,5578,1241,57556,3383,713,595,2280,4609,1280,2596,3952,9423,8398,1464,4155,3164,7832,1019,2902,7431,900,4099,4804,2353,983,1956,388,3554,1647,1462,3576,176,2212,2668,65078,4843,56963	MMP9,EFNB2,CHST11,EGR1,SELP,RHOC,SOX9,IL4,PLXNA2,AQP1,SLIT3,RTN4,BCAN,PRKCA,LTB4R,SEMA6A,ICAM1,C1QB,CCND1,FKBP1A,MYC,COL2A1,GAP43,LEP,NTN1,PLA2G6,CSPG4,MBP,NR4A1,BTG2,CDK4,GRIN1,VIM,CCNG1,MAG,NGFR,FOS,CDK1,EGFR,RHOB,IL1R1,GADD45A,VCAN,IL8,ACAN,FCGR2A,GDNF,RTN4R,NOS2,RGMA
WP474	Endochondral Ossification	0.750481269018546	-0.287040586223346	66	29	0.013595874355368	2133	4508	4318,860,50515,207,1028,9507,5745,7067,6662,4921,5727,864,7042,7422,5566,2688,2260,2261,5167,3157,9759,1515,8817,1280,176,11127,657,55553,4208	MMP9,RUNX2,CHST11,AKT1,CDKN1C,ADAMTS4,PTH1R,THRA,SOX9,DDR2,PTCH1,RUNX3,TGFB2,VEGFA,PRKACA,GH1,FGFR1,FGFR3,ENPP1,HMGCS1,HDAC4,CTSV,FGF18,COL2A1,ACAN,KIF3A,BMPR1A,SOX6,MEF2C
WP247	Small Ligand GPCRs	0.752388593304908	-0.284502342083648	19	8	0.00375058602906704	2133	4508	8698,5724,5732,4544,4543,5739,5731,1903	S1PR4,PTAFR,PTGER2,MTNR1B,MTNR1A,PTGIR,PTGER1,S1PR3
WP1971	Integrated Cancer pathway	0.757366101866801	-0.277908520435214	35	15	0.0070323488045007	2133	4508	4088,993,4087,207,10811,1019,10111,472,545,1111,994,672,641,580,983	SMAD3,CDC25A,SMAD2,AKT1,NOXA1,CDK4,RAD50,ATM,ATR,CHEK1,CDC25B,BRCA1,BLM,BARD1,CDK1
WP2289	Drug Induction of Bile Acid Pathway	0.772588568389787	-0.258008625144968	17	7	0.00328176277543366	2133	4508	7421,200931,9970,8714,1244,10257,9971	VDR,SLC51A,NR1I3,ABCC3,ABCC2,ABCC4,NR1H4
WP554	ACE Inhibitor Pathway	0.772588568389787	-0.258008625144968	17	7	0.00328176277543366	2133	4508	623,183,1636,4306,5972,1585,10159	BDKRB1,AGT,ACE,NR3C2,REN,CYP11B2,ATP6AP2
WP1995	Effects of nitric oxide	0.777287151149262	-0.251945432987743	5	2	0.00093764650726676	2133	4508	4843,4151	NOS2,MB
WP47	Hedgehog Signaling Pathway	0.792417278607719	-0.232667158984422	22	9	0.00421940928270042	2133	4508	1859,2736,6469,5727,25942,891,983,2619,6497	DYRK1A,GLI2,SHH,PTCH1,SIN3A,CCNB1,CDK1,GAS1,SKI
WP1559	TFs Regulate miRNAs related to cardiac hypertrophy	0.795028867285685	-0.229376853935859	15	6	0.00281293952180028	2133	4508	5923,207,6774,406911,4790,406991	RASGRF1,AKT1,STAT3,MIR125B1,NFKB1,MIR21
WP550	Biogenic Amine Synthesis	0.795028867285685	-0.229376853935859	15	6	0.00281293952180028	2133	4508	4128,1312,43,1103,1644,15	MAOA,COMT,ACHE,CHAT,DDC,AANAT
WP143	Fatty Acid Beta Oxidation	0.813521536174143	-0.20638287919572	34	14	0.00656352555086732	2133	4508	51703,35,1666,2180,3033,55902,1384,57104,2181,23305,1120,2639,3990,37	ACSL5,ACADS,DECR1,ACSL1,HADH,ACSS2,CRAT,PNPLA2,ACSL3,ACSL6,CHKB,GCDH,LIPC,ACADVL
WP1604	Codeine and morphine metabolism	0.817598569592441	-0.201383809054236	8	3	0.00140646976090014	2133	4508	8714,1244,1565	ABCC3,ABCC2,CYP2D6
WP699	Aflatoxin B1 metabolism	0.817598569592441	-0.201383809054236	8	3	0.00140646976090014	2133	4508	22977,8574,2052	AKR7A3,AKR7A2,EPHX1
WP322	Osteoblast Signaling	0.820177534586887	-0.198234456564027	13	5	0.0023441162681669	2133	4508	4982,3685,5745,1277,5159	TNFRSF11B,ITGAV,PTH1R,COL1A1,PDGFRB
WP666	Hypothetical Network for Drug Addiction	0.825790863023558	-0.191413729985209	32	13	0.00609470229723394	2133	4508	54386,22882,2890,816,114,58,2902,107,1385,5566,5605,1815,1812	TERF2IP,ZHX2,GRIA1,CAMK2B,ADCY8,ACTA1,GRIN1,ADCY1,CREB1,PRKACA,MAP2K2,DRD4,DRD1
WP1434	Osteopontin Signaling	0.848618659007802	-0.164145358466249	11	4	0.00187529301453352	2133	4508	4318,9020,3551,4790	MMP9,MAP3K14,IKBKB,NFKB1
WP1601	Fluoropyrimidine Activity	0.850958492379555	-0.161391926710464	35	14	0.00656352555086732	2133	4508	1890,2356,10257,5471,1548,7378,1807,7371,1066,83549,6241,7517,8714,100500832	TYMP,FPGS,ABCC4,PPAT,CYP2A6,UPP1,DPYS,UCK2,CES1,UCK1,RRM2,XRCC3,ABCC3,MIR3658
WP530	Cytokines and Inflammatory Response	0.851754767632336	-0.16045662500168	28	11	0.00515705578996718	2133	4508	3123,5154,1440,920,3600,1435,3596,3565,3586,1437,3567	HLA-DRB1,PDGFA,CSF3,CD4,IL15,CSF1,IL13,IL4,IL10,CSF2,IL5
WP259	Nifedipine Activity	0.863554615825863	-0.146698134031504	6	2	0.00093764650726676	2133	4508	2185,5111	PTK2B,PCNA
WP1600	Nicotine metabolism	0.863554615825863	-0.146698134031504	6	2	0.00093764650726676	2133	4508	1548,2328	CYP2A6,FMO3
WP129	Matrix Metalloproteinases	0.873970330474344	-0.134708850728501	31	12	0.00562587904360056	2133	4508	4318,4324,4320,79148,4326,4317,4313,8510,4323,682,4327,8511	MMP9,MMP15,MMP11,MMP28,MMP17,MMP8,MMP2,MMP23B,MMP14,BSG,MMP19,MMP23A
WP272	Blood Clotting Cascade	0.879678276866368	-0.128199032825873	24	9	0.00421940928270042	2133	4508	2165,7450,5054,2147,2159,5345,2155,2153,5055	F13B,VWF,SERPINE1,F2,F10,SERPINF2,F7,F5,SERPINB2
WP1530	miRNA Regulation of DNA Damage Response	0.881039770311097	-0.126652511827498	9	3	0.00140646976090014	2133	4508	5981,1385,4609	RFC1,CREB1,MYC
WP545	Complement Activation, Classical Pathway	0.893116551494364	-0.113038189831212	17	6	0.00281293952180028	2133	4508	713,718,1604,712,729,714	C1QB,C3,CD55,C1QA,C6,C1QC
WP78	TCA Cycle	0.893116551494364	-0.113038189831212	17	6	0.00281293952180028	2133	4508	6390,3418,4967,6391,1743,2271	SDHB,IDH2,OGDH,SDHC,DLST,FH
WP727	Monoamine Transport	0.902878010939808	-0.102167827780959	32	12	0.00562587904360056	2133	4508	3554,114907,11255,7249,183,6804,6531,10066,4982,1432,995,43	IL1R1,FBXO32,HRH3,TSC2,AGT,STX1A,SLC6A3,SCAMP2,TNFRSF11B,MAPK14,CDC25C,ACHE
WP2197	Endothelin	0.917091228694851	-0.0865483256382552	35	13	0.00609470229723394	2133	4508	790,2769,5739,284485,5894,4638,1906,51764,1889,5578,10267,55811,148	CAD,GNA15,PTGIR,RIIAD1,RAF1,MYLK,EDN1,GNG13,ECE1,PRKCA,RAMP1,ADCY10,ADRA1A
WP100	Glutathione metabolism	0.922963740513694	-0.0801653296347998	23	8	0.00375058602906704	2133	4508	653689,2678,26873,2878,2687,2876,290,2879	GSTT2B,GGT1,OPLAH,GPX3,GGT5,GPX1,ANPEP,GPX4
WP2253	pilocytic astrocytoma	0.923051651490036	-0.080070085600769	4	1	0.00046882325363338	2133	4508	5781	PTPN11
WP690	Polyol pathway	0.923051651490036	-0.080070085600769	4	1	0.00046882325363338	2133	4508	3795	KHK
WP2113	Type III interferon signaling	0.923989944640985	-0.0790540898228428	10	3	0.00140646976090014	2133	4508	3588,7297,10379	IL10RB,TYK2,IRF9
WP1455	Serotonin Transporter Activity	0.923989944640985	-0.0790540898228428	10	3	0.00140646976090014	2133	4508	4128,10066,6804	MAOA,SCAMP2,STX1A
WP692	Sulfation Biotransformation Reaction	0.924838679309523	-0.0781359574257519	18	6	0.00281293952180028	2133	4508	445329,6820,100526830,9061,6818,25830	SULT1A4,SULT2B1,SLX1A-SULT1A3,PAPSS1,SULT1A3,SULT4A1
WP75	Toll-like receptor signaling pathway	0.926135058367012	-0.0767352036029712	103	42	0.019690576652602	2133	4508	7189,942,1326,8737,3661,1432,5606,3725,3654,23533,5296,4790,6351,5601,3551,5290,8503,5600,54106,6885,4791,7100,100302736,29110,5609,207,5295,929,3454,2353,54472,5605,8772,8517,9641,23118,10000,4792,3576,7187,3665,6300	TRAF6,CD86,MAP3K8,RIPK1,IRF3,MAPK14,MAP2K3,JUN,IRAK1,PIK3R5,PIK3R2,NFKB1,CCL4,MAPK9,IKBKB,PIK3CA,PIK3R3,MAPK11,TLR9,MAP3K7,NFKB2,TLR5,TMED7-TICAM2,TBK1,MAP2K7,AKT1,PIK3R1,CD14,IFNAR1,FOS,TOLLIP,MAP2K2,FADD,IKBKG,IKBKE,TAB2,AKT3,NFKBIA,IL8,TRAF3,IRF7,MAPK12
WP368	Mitochondrial LC-Fatty Acid Beta-Oxidation	0.940373542649516	-0.0614780968575545	16	5	0.0023441162681669	2133	4508	35,2180,3033,37,2181	ACADS,ACSL1,HADH,ACADVL,ACSL3
WP1449	Regulation of toll-like receptor signaling pathway	0.940774553362719	-0.0610517500748342	102	41	0.0192217533989686	2133	4508	7189,942,1326,8737,3661,1432,5606,3725,3654,23533,3551,4790,5296,6351,5601,5290,8503,5600,54106,4791,6885,7100,64223,29110,207,5609,5295,929,3454,54472,2353,5605,8772,8517,9641,10000,3576,4792,3665,7187,6300	TRAF6,CD86,MAP3K8,RIPK1,IRF3,MAPK14,MAP2K3,JUN,IRAK1,PIK3R5,IKBKB,NFKB1,PIK3R2,CCL4,MAPK9,PIK3CA,PIK3R3,MAPK11,TLR9,NFKB2,MAP3K7,TLR5,MLST8,TBK1,AKT1,MAP2K7,PIK3R1,CD14,IFNAR1,TOLLIP,FOS,MAP2K2,FADD,IKBKG,IKBKE,AKT3,IL8,NFKBIA,IRF7,TRAF3,MAPK12
WP1001	Peptide GPCRs	0.952254176749303	-0.0489232874431739	11	3	0.00140646976090014	2133	4508	4987,4888,6754	OPRL1,NPY6R,SSTR4
WP229	Irinotecan Pathway	0.955740277144985	-0.0452690794681007	14	4	0.00187529301453352	2133	4508	54578,324,1244,1066	UGT1A6,APC,ABCC2,CES1
WP521	Amino acid conjugation of benzoic acid	0.959492776579167	-0.0413504918804201	5	1	0.00046882325363338	2133	4508	55902	ACSS2
WP311	Synthesis and Degradation of Ketone Bodies	0.959492776579167	-0.0413504918804201	5	1	0.00046882325363338	2133	4508	622	BDH1
WP1589	Folate-Alcohol and Cancer Pathway	0.959492776579167	-0.0413504918804201	5	1	0.00046882325363338	2133	4508	875	CBS
WP2059	Alzheimers Disease	0.96406270357453	-0.0365989412851446	79	30	0.0140646976090014	2133	4508	6868,2597,51107,489,322,2902,9451,54205,3710,637,351,8851,8772,5331,355,1020,824,51806,3708,7132,5664,5332,2932,5533,22926,779,317,5330,810,4311	ADAM17,GAPDH,APH1A,ATP2A3,APBB1,GRIN1,EIF2AK3,CYCS,ITPR3,BID,APP,CDK5R1,FADD,PLCB3,FAS,CDK5,CAPN2,CALML5,ITPR1,TNFRSF1A,PSEN2,PLCB4,GSK3B,PPP3CC,ATF6,CACNA1S,APAF1,PLCB2,CALML3,MME
WP183	Proteasome Degradation	0.966075807417668	-0.0345129722610192	65	24	0.0112517580872011	2133	4508	7323,5689,5684,5692,7317,5721,5710,7347,5685,7316,3105,5704,6184,5699,5696,5687,5709,5714,5701,7322,7320,3107,10197,5686	UBE2D3,PSMB1,PSMA3,PSMB4,UBA1,PSME2,PSMD4,UCHL3,PSMA4,UBC,HLA-A,PSMC4,RPN1,PSMB10,PSMB8,PSMA6,PSMD3,PSMD8,PSMC2,UBE2D2,UBE2B,HLA-C,PSME3,PSMA5
WP405	Eukaryotic Transcription Initiation	0.969270249117643	-0.0312118111170636	41	14	0.00656352555086732	2133	4508	661,2967,5438,2961,902,5439,2968,6908,5440,55718,5434,5437,64425,51728	POLR3D,GTF2H3,POLR2I,GTF2E2,CCNH,POLR2J,GTF2H4,TBP,POLR2K,POLR3E,POLR2E,POLR2H,POLR1E,POLR3K
WP465	Tryptophan metabolism	0.969587081125762	-0.0308849876773009	46	16	0.00750117205813408	2133	4508	1588,130013,3276,4967,2639,51366,847,7337,3033,8942,23498,15,66002,125061,224,1644	CYP19A1,ACMSD,PRMT1,OGDH,GCDH,UBR5,CAT,UBE3A,HADH,KYNU,HAAO,AANAT,CYP4F12,AFMID,ALDH3A2,DDC
WP2007	Iron metabolism in placenta	0.970437059454884	-0.0300087322063221	12	3	0.00140646976090014	2133	4508	55240,7037,48	STEAP3,TFRC,ACO1
WP696	Benzo(a)pyrene metabolism	0.971716839453384	-0.0286908343976549	9	2	0.00093764650726676	2133	4508	1646,2052	AKR1C2,EPHX1
WP43	cytochrome P450	0.978423235215614	-0.0218129467149371	62	22	0.0103141115799344	2133	4508	56603,1591,1588,1565,1589,10858,51167,57404,285440,80777,5447,1585,1592,1528,54905,1584,1583,57834,120227,51706,66002,1727	CYP26B1,CYP24A1,CYP19A1,CYP2D6,CYP21A2,CYP46A1,CYB5R4,CYP20A1,CYP4V2,CYB5B,POR,CYP11B2,CYP26A1,CYB5A,CYP2W1,CYP11B1,CYP11A1,CYP4F11,CYP2R1,CYB5R1,CYP4F12,CYB5R3
WP299	Nuclear receptors in lipid metabolism and toxicity	0.98154057832703	-0.0186319229444446	35	11	0.00515705578996718	2133	4508	693120,1591,7421,9970,8714,1244,5914,5825,9971,1592,9619	MIR33B,CYP24A1,VDR,NR1I3,ABCC3,ABCC2,RARA,ABCD3,NR1H4,CYP26A1,ABCG1
WP1533	Vitamin B12 Metabolism	0.982775590281185	-0.0173744755572851	19	5	0.0023441162681669	2133	4508	949,6647,4791,4353,3630	SCARB1,SOD1,NFKB2,MPO,INS
WP2328	Allograft Rejection	0.983888506272153	-0.0162426949835557	38	12	0.00562587904360056	2133	4508	3123,3113,942,3565,356,3586,3107,5551,940,3567,3105,355	HLA-DRB1,HLA-DPA1,CD86,IL4,FASLG,IL10,HLA-C,PRF1,CD28,IL5,HLA-A,FAS
WP1433	NOD pathway	0.988454359135426	-0.01161280927816	39	12	0.00562587904360056	2133	4508	10910,8517,9447,22861,114548,64170,3551,4792,64127,3606,50506,3320	SUGT1,IKBKG,AIM2,NLRP1,NLRP3,CARD9,IKBKB,NFKBIA,NOD2,IL18,DUOX2,HSP90AA1
WP1310	Selenium	0.988781405660547	-0.0112819974104749	7	1	0.00046882325363338	2133	4508	7296	TXNRD1
WP1272	Selenium	0.988781405660547	-0.0112819974104749	7	1	0.00046882325363338	2133	4508	7296	TXNRD1
WP136	Phase I, non P450	0.988781405660547	-0.0112819974104749	7	1	0.00046882325363338	2133	4508	3988	LIPA
WP623	Oxidative phosphorylation	0.988857146623857	-0.0112054000330016	62	21	0.00984528832630099	2133	4508	516,4729,4712,4726,537,521,4697,514,374291,4695,517,10476,126328,4728,4715,4731,498,4700,4713,4720,10159	ATP5G1,NDUFV2,NDUFB6,NDUFS6,ATP6AP1,ATP5I,NDUFA4,ATP5E,NDUFS7,NDUFA2,ATP5G2,ATP5H,NDUFA11,NDUFS8,NDUFB9,NDUFV3,ATP5A1,NDUFA6,NDUFB7,NDUFS2,ATP6AP2
WP619	Type II interferon signaling (IFNG)	0.99068379194326	-0.0093598753436441	50	16	0.00750117205813408	2133	4508	3662,8651,8370,3460,5580,10379,5781,6890,3717,3394,6688,4843,4261,3383,9021,3659	IRF4,SOCS1,HIST2H4A,IFNGR2,PRKCD,IRF9,PTPN11,TAP1,JAK2,IRF8,SPI1,NOS2,CIITA,ICAM1,SOCS3,IRF1
WP1545	miRNAs involved in DDR	0.994484045992472	-0.00553122305663515	72	24	0.0112517580872011	2133	4508	406881,407010,100616173,993,407026,406991,5893,1026,407007,406992,407006,406937,898,595,25,406935,4609,896,406971,406986,472,406884,1385,406955	MIRLET7A1,MIR23A,MIR3545,CDC25A,MIR29C,MIR21,RAD52,CDKN1A,MIR222,MIR210,MIR221,MIR145,CCNE1,CCND1,ABL1,MIR143,MYC,CCND3,MIR195,MIR203,ATM,MIRLET7B,CREB1,MIR181B1
WP698	Glucuronidation	0.997146052851048	-0.00285802742122033	26	6	0.00281293952180028	2133	4508	54578,5236,3098,7363,7360,7358	UGT1A6,PGM1,HK1,UGT2B4,UGP2,UGDH
WP697	Estrogen metabolism	0.997697887791076	-0.00230476614312049	17	3	0.00140646976090014	2133	4508	54578,1312,1728	UGT1A6,COMT,NQO1
WP702	metapathway biotransformation	0.99773406487948	-0.00226850623622719	182	68	0.0318799812470699	2133	4508	1591,4166,1588,26151,9196,2878,79829,10858,55226,64090,64711,1585,1592,54905,9951,7881,1646,57834,2941,1312,6820,8514,2879,2954,57404,3340,653689,9394,1584,1583,9953,166012,9955,266722,57106,50515,8534,7363,4837,9957,1589,285440,113189,2950,100526830,80218,54578,8574,2328,2052,56603,1565,2326,8509,4259,57016,25830,6818,119391,2327,22977,2329,120227,339983,9469,51126,445329,66002	CYP24A1,CHST6,CYP19A1,NAT9,KCNAB3,GPX3,NAA40,CYP46A1,NAT10,GAL3ST2,HS3ST6,CYP11B2,CYP26A1,CYP2W1,HS3ST4,KCNAB1,AKR1C2,CYP4F11,GSTA4,COMT,SULT2B1,KCNAB2,GPX4,GSTZ1,CYP20A1,NDST1,GSTT2B,HS6ST1,CYP11B1,CYP11A1,HS3ST3B1,CHST13,HS3ST3A1,HS6ST3,NAT14,CHST11,CHST1,UGT2B4,NNMT,HS3ST1,CYP21A2,CYP4V2,CHST14,GSTP1,SLX1A-SULT1A3,NAA50,UGT1A6,AKR7A2,FMO3,EPHX1,CYP26B1,CYP2D6,FMO1,NDST2,MGST3,AKR1B10,SULT4A1,SULT1A3,GSTO2,FMO2,AKR7A3,FMO4,CYP2R1,NAT8L,CHST3,NAA20,SULT1A4,CYP4F12
WP24	Peptide GPCRs	0.998801897832841	-0.00119882046534774	72	22	0.0103141115799344	2133	4508	6755,1236,4887,552,4923,23620,3973,2492,2532,553,1233,6865,4157,5540,4987,4888,2587,6754,623,7201,1234,6870	SSTR5,CCR7,NPY2R,AVPR1A,NTSR1,NTSR2,LHCGR,FSHR,DARC,AVPR1B,CCR4,TACR2,MC1R,NPY4R,OPRL1,NPY6R,GALR1,SSTR4,BDKRB1,TRHR,CCR5,TACR3
WP206	Fatty Acid Omega Oxidation	0.999047227901	-0.000953226274842842	15	2	0.00093764650726676	2133	4508	1565,1548	CYP2D6,CYP2A6
WP691	Tamoxifen metabolism	0.999212911814984	-0.000787398101553374	19	3	0.00140646976090014	2133	4508	1565,2326,2328	CYP2D6,FMO1,FMO3
WP117	GPCRs, Other	0.999499879555309	-0.000500245546632994	98	31	0.0145335208626348	2133	4508	29933,29929,9620,1952,9289,1951,2840,4923,154,2492,2532,1815,79541,4992,53831,3363,83873,401428,9290,59350,283383,26245,84059,144124,441295,23266,1234,1131,23284,59352,5032	GPR132,ALG6,CELSR1,CELSR2,GPR56,CELSR3,GPR17,NTSR1,ADRB2,FSHR,DARC,DRD4,OR2A4,OR1F1,GPR84,HTR7,GPR61,OR2A20P,GPR55,RXFP1,GPR133,OR2M4,GPR98,OR10A5,OR2A9P,LPHN2,CCR5,CHRM3,LPHN3,LGR6,P2RY11
WP477	Cytoplasmic Ribosomal Proteins	0.99954063226749	-0.000459473274189668	121	40	0.0187529301453352	2133	4508	6202,6181,6195,6235,23521,6135,6137,6234,6196,6141,6205,6170,26817,116938,6199,6154,6159,7311,6160,6132,6169,6229,6232,6142,4736,6203,3921,6189,25873,26795,6191,6161,6208,606500,6223,6176,6198,6206,6188,6146	RPS8,RPLP2,RPS6KA1,RPS29,RPL13A,RPL11,RPL13,RPS28,RPS6KA2,RPL18,RPS11,RPL39,SNORD34,SNORD83B,RPS6KB2,RPL26,RPL29,UBA52,RPL31,RPL8,RPL38,RPS24,RPS27,RPL18A,RPL10A,RPS9,RPSA,RPS3A,RPL36,SNORD54,RPS4X,RPL32,RPS14,SNORD68,RPS19,RPLP1,RPS6KB1,RPS12,RPS3,RPL22
WP111	Electron Transport Chain	0.999551866154249	-0.000448234287732061	106	34	0.0159399906235349	2133	4508	4729,4712,6391,1346,29796,4726,521,1327,4697,1345,374291,4695,517,10476,7385,4728,4715,4731,4700,4720,516,93974,1350,27089,514,6390,291,440567,9167,1351,9377,498,4713,1340	NDUFV2,NDUFB6,SDHC,COX7A1,UQCR10,NDUFS6,ATP5I,COX4I1,NDUFA4,COX6C,NDUFS7,NDUFA2,ATP5G2,ATP5H,UQCRC2,NDUFS8,NDUFB9,NDUFV3,NDUFA6,NDUFS2,ATP5G1,ATPIF1,COX7C,UQCRQ,ATP5E,SDHB,SLC25A4,UQCRHL,COX7A2L,COX8A,COX5A,ATP5A1,NDUFB7,COX6B1
WP455	GPCRs, Class A Rhodopsin-like	0.999998844403408	-1.1555972596393e-06	260	87	0.0407876230661041	2133	4508	5724,266747,54328,2848,4544,552,2840,4923,57105,5732,9002,1241,4992,3352,2859,56923,57121,26476,4157,3362,4888,6754,8111,148,152,8386,2827,1132,3973,56670,3363,1233,26188,728458,5540,144124,5032,11255,1236,57007,3358,4887,1128,2832,23620,5028,136,64106,2492,1815,3274,79541,147,1816,134,2843,23596,11251,2587,623,4543,1131,23432,150,5029,3354,6755,5739,9293,26696,10316,154,9283,3360,553,2652,10161,4987,2863,2852,7201,94233,1234,3269,2847,1812,5731	PTAFR,RGL4,GPR173,GPR25,MTNR1B,AVPR1A,GPR17,NTSR1,CYSLTR2,PTGER2,F2RL3,LTB4R,OR1F1,HTR1D,GPR35,NMUR2,LPAR5,OR10J1,MC1R,HTR6,NPY6R,SSTR4,GPR68,ADRA1A,ADRA2C,OR1D5,GPR3,CHRM4,LHCGR,SUCNR1,HTR7,CCR4,OR1C1,OPN1MW2,NPY4R,OR10A5,P2RY11,HRH3,CCR7,ACKR3,HTR2C,NPY2R,CHRM1,NPBWR2,NTSR2,P2RY1,ADORA2B,NPFFR1,FSHR,DRD4,HRH2,OR2A4,ADRA1B,DRD5,ADORA1,GPR20,OPN3,PTGDR2,GALR1,BDKRB1,MTNR1A,CHRM3,GPR161,ADRA2A,P2RY2,HTR1E,SSTR5,PTGIR,GPR52,OR2T1,NMUR1,ADRB2,GPR37L1,HTR4,AVPR1B,OPN1MW,LPAR6,OPRL1,GPR39,GPER1,TRHR,OPN4,CCR5,HRH1,MCHR1,DRD1,PTGER1
WP1273	Folic Acid Network	0.999999999992915	-7.08466618704051e-12	2	0	0	2133	4508
WP1075	Folic Acid Network	0.999999999992915	-7.08466618704051e-12	2	0	0	2133	4508
WP1311	Folic Acid Network	0.999999999992915	-7.08466618704051e-12	2	0	0	2133	4508
WP2435	Quercetin and Nf-kB/ AP-1 induced cell apoptosis	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP1438	Influenza A virus infection	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP2338	miRNA Biogenesis	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP1	Statin Pathway	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP222	Cytokines and Inflammatory Response (BioCarta)	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP1006	metapathway biotransformation	1.00000000000506	5.0558446318405e-12	1	0	0	2133	4508
WP694	Arylamine metabolism	1.00000000000548	5.48081111745313e-12	7	0	0	2133	4508
WP1603	Nicotine Activity on Chromaffin Cells	1.00000000000754	7.5410580557822e-12	4	0	0	2133	4508