TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols rac1_reg_pathway Regulation of RAC1 activity 0.00628543947842549 -5.06951951441631 39 11 0.039568345323741 278 2226 1123,10451,1124,1793,5924,2059,57580,221178,57572,1794,26230 CHN1,VAV3,CHN2,DOCK1,RASGRF2,EPS8,PREX1,SPATA13,DOCK6,DOCK2,TIAM2 arf6_pathway Arf6 signaling events 0.0199461979683728 -3.91471673183499 34 9 0.0323741007194245 278 2226 5829,116984,9265,3690,3082,51454,26034,4233,7253 PXN,ARAP2,CYTH3,ITGB3,HGF,GULP1,IPCEF1,MET,TSHR fgf_pathway FGF signaling pathway 0.0262097023948274 -3.64162561635351 47 11 0.039568345323741 278 2226 2264,54756,860,3082,6777,2017,4684,4233,1000,10253,2260 FGFR4,IL17RD,RUNX2,HGF,STAT5B,CTTN,NCAM1,MET,CDH2,SPRY2,FGFR1 p38gammadeltapathway Signaling mediated by p38-gamma and p38-delta 0.0270715263134297 -3.60927279299902 10 4 0.0143884892086331 278 2226 5603,5585,51776,5608 MAPK13,PKN1,MAP3K20,MAP2K6 mtor_4pathway mTOR signaling pathway 0.0300765015450853 -3.50401109168156 60 13 0.0467625899280576 278 2226 5829,1938,1978,6720,64798,6446,664,5337,5578,10891,8945,2810,54541 PXN,EEF2,EIF4EBP1,SREBF1,DEPTOR,SGK1,BNIP3,PLD1,PRKCA,PPARGC1A,BTRC,SFN,DDIT4 p53downstreampathway Direct p53 effectors 0.0328918543287648 -3.41453024065732 132 24 0.0863309352517986 278 2226 7039,665,80781,467,900,8794,639,27244,22943,54541,5366,57060,604,27113,3082,55240,4233,3169,25946,2810,6591,64065,1843,3486 TGFA,BNIP3L,COL18A1,ATF3,CCNG1,TNFRSF10C,PRDM1,SESN1,DKK1,DDIT4,PMAIP1,PCBP4,BCL6,BBC3,HGF,STEAP3,MET,FOXA1,ZNF385A,SFN,SNAI2,PERP,DUSP1,IGFBP3 myc_represspathway Validated targets of C-MYC transcriptional repression 0.0697115320067118 -2.66338952286817 61 12 0.0431654676258993 278 2226 4609,3655,84233,57447,1050,23671,81855,2672,1649,5159,1052,22943 MYC,ITGA6,TMEM126A,NDRG2,CEBPA,TMEFF2,SFXN3,GFI1,DDIT3,PDGFRB,CEBPD,DKK1 ptp1bpathway Signaling events mediated by PTP1B 0.0850929434176471 -2.46401116790268 50 10 0.0359712230215827 278 2226 2241,2268,1447,1435,3690,6777,1000,3953,10253,5159 FER,FGR,CSN2,CSF1,ITGB3,STAT5B,CDH2,LEPR,SPRY2,PDGFRB vegfr1_2_pathway Signaling events mediated by VEGFR1 and VEGFR2 0.0852088691640529 -2.46264975239507 63 12 0.0431654676258993 278 2226 7424,5058,5829,9047,5777,3690,2887,5578,8829,2242,4734,4846 VEGFC,PAK1,PXN,SH2D2A,PTPN6,ITGB3,GRB10,PRKCA,NRP1,FES,NEDD4,NOS3 botulinumtoxinpathway Effects of Botulinum toxin 0.0912942943329141 -2.39366698694942 9 3 0.0107913669064748 278 2226 6616,10497,6812 SNAP25,UNC13B,STXBP1 fcer1pathway Fc-epsilon receptor I signaling in mast cells 0.0992631472791724 -2.30998090189883 58 11 0.039568345323741 278 2226 5321,2241,8611,5829,5579,5783,1147,3937,6850,9846,1843 PLA2G4A,FER,PLPP1,PXN,PRKCB,PTPN13,CHUK,LCP2,SYK,GAB2,DUSP1 rhoa_reg_pathway Regulation of RhoA activity 0.110838111763574 -2.1996845948274 46 9 0.0323741007194245 278 2226 55160,10451,64283,10160,9826,23263,57522,4983,84033 ARHGEF10L,VAV3,ARHGEF28,FARP1,ARHGEF11,MCF2L,SRGAP1,OPHN1,OBSCN wnt_signaling_pathway Wnt signaling network 0.126904138334613 -2.06432329380366 28 6 0.0215827338129496 278 2226 4040,8322,8325,83999,22943,8321 LRP6,FZD4,FZD8,KREMEN1,DKK1,FZD1 igf1_pathway IGF1 pathway 0.126904138334613 -2.06432329380366 28 6 0.0215827338129496 278 2226 8660,2887,10399,5829,3480,5580 IRS2,GRB10,RACK1,PXN,IGF1R,PRKCD p38alphabetadownstreampathway Signaling mediated by p38-alpha and p38-beta 0.13732796860349 -1.98538328263054 35 7 0.0251798561151079 278 2226 1051,5321,9261,10891,1978,1649,4208 CEBPB,PLA2G4A,MAPKAPK2,PPARGC1A,EIF4EBP1,DDIT3,MEF2C alk2pathway ALK2 signaling events 0.148953811772293 -1.90411900919834 11 3 0.0107913669064748 278 2226 90,659,4093 ACVR1,BMPR2,SMAD9 nfkappabalternativepathway Alternative NF-kappaB pathway 0.166090232728581 -1.79522406765251 6 2 0.00719424460431655 278 2226 1147,8945 CHUK,BTRC ephrinb_ephbpathway EphrinB-EPHB pathway 0.166090232728581 -1.79522406765251 6 2 0.00719424460431655 278 2226 1948,2047 EFNB2,EPHB1 alk1pathway ALK1 signaling events 0.171383398676518 -1.76385213470593 24 5 0.0179856115107914 278 2226 92,3397,90,659,4093 ACVR2A,ID1,ACVR1,BMPR2,SMAD9 ret_pathway Signaling events regulated by Ret tyrosine kinase 0.187894851821127 -1.67187277144191 38 7 0.0251798561151079 278 2226 9260,8660,2887,5829,5578,2674,55816 PDLIM7,IRS2,GRB10,PXN,PRKCA,GFRA1,DOK5 avb3_opn_pathway Osteopontin-mediated events 0.201951458004229 -1.59972791736902 32 6 0.0215827338129496 278 2226 5058,10451,1147,2934,6850,3690 PAK1,VAV3,CHUK,GSN,SYK,ITGB3 alphasynuclein_pathway Alpha-synuclein signaling 0.201951458004229 -1.59972791736902 32 6 0.0215827338129496 278 2226 5071,5337,2268,6850,5580,6622 PRKN,PLD1,FGR,SYK,PRKCD,SNCA tcr_pathway TCR signaling in naive CD4+ T cells 0.208196254495569 -1.56927411289792 60 10 0.0359712230215827 278 2226 5788,5588,1147,6452,3937,5578,5579,5777,10125,9846 PTPRC,PRKCQ,CHUK,SH3BP2,LCP2,PRKCA,PRKCB,PTPN6,RASGRP1,GAB2 erbb_network_pathway ErbB receptor signaling network 0.215116167384021 -1.53657708335716 13 3 0.0107913669064748 278 2226 685,10718,7039 BTC,NRG3,TGFA ncadherinpathway N-cadherin signaling events 0.222852427471851 -1.50124548679787 33 6 0.0215827338129496 278 2226 747,2934,2241,2017,1000,2260 DAGLA,GSN,FER,CTTN,CDH2,FGFR1 s1p_s1p1_pathway S1P1 pathway 0.233531909563916 -1.45443655354868 20 4 0.0143884892086331 278 2226 2775,5159,3690,2770 GNAO1,PDGFRB,ITGB3,GNAI1 plk2_4pathway PLK2 and PLK4 events 0.234227565943257 -1.4514621321691 2 1 0.00359712230215827 278 2226 10769 PLK2 p38alphabetapathway Regulation of p38-alpha and p38-beta 0.241408962900721 -1.42126284217316 27 5 0.0179856115107914 278 2226 5058,2268,1850,5608,1843 PAK1,FGR,DUSP8,MAP2K6,DUSP1 ephrinbrevpathway Ephrin B reverse signaling 0.241408962900721 -1.42126284217316 27 5 0.0179856115107914 278 2226 1948,2268,2047,5783,3690 EFNB2,FGR,EPHB1,PTPN13,ITGB3 atf2_pathway ATF-2 transcription factor network 0.241720760605772 -1.41997210085393 55 9 0.0323741007194245 278 2226 1850,122953,8739,467,5578,10891,1466,1649,1843 DUSP8,JDP2,HRK,ATF3,PRKCA,PPARGC1A,CSRP2,DDIT3,DUSP1 cd8tcrpathway TCR signaling in naive CD8+ T cells 0.24375812828763 -1.41157882283913 48 8 0.0287769784172662 278 2226 5788,5588,1147,3937,5578,5579,5777,10125 PTPRC,PRKCQ,CHUK,LCP2,PRKCA,PRKCB,PTPN6,RASGRP1 nfkappabatypicalpathway Atypical NF-kappaB pathway 0.250204333185842 -1.38547736221104 14 3 0.0107913669064748 278 2226 6850,5966,8945 SYK,REL,BTRC s1p_s1p5_pathway S1P5 pathway 0.263253082616768 -1.33463941819134 8 2 0.00719424460431655 278 2226 2775,2770 GNAO1,GNAI1 s1p_s1p3_pathway S1P3 pathway 0.266301316067161 -1.32312684412729 28 5 0.0179856115107914 278 2226 2775,10000,5159,3690,2770 GNAO1,AKT3,PDGFRB,ITGB3,GNAI1 met_pathway Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 0.282295135695475 -1.26480217484715 72 11 0.039568345323741 278 2226 5058,54453,5829,3636,5795,6456,1978,64798,3082,4233,9846 PAK1,RIN2,PXN,INPPL1,PTPRJ,SH3GL2,EIF4EBP1,DEPTOR,HGF,MET,GAB2 bmppathway BMP receptor signaling 0.289232450387066 -1.24052458756815 36 6 0.0215827338129496 278 2226 659,4093,4091,654,91851,6497 BMPR2,SMAD9,SMAD6,BMP6,CHRDL1,SKI cdc42_reg_pathway Regulation of CDC42 activity 0.317572780652997 -1.14704825651552 30 5 0.0179856115107914 278 2226 10451,57572,23263,23348,221178 VAV3,DOCK6,MCF2L,DOCK9,SPATA13 il2_1pathway IL2-mediated signaling events 0.319889386477188 -1.13978001020385 52 8 0.0287769784172662 278 2226 8660,9261,22806,5579,4609,6777,6850,9846 IRS2,MAPKAPK2,IKZF3,PRKCB,MYC,STAT5B,SYK,GAB2 nfkappabcanonicalpathway Canonical NF-kappaB pathway 0.32158241080455 -1.13450143594495 23 4 0.0143884892086331 278 2226 1147,5578,8945,7132 CHUK,PRKCA,BTRC,TNFRSF1A txa2pathway Thromboxane A2 receptor signaling 0.327617009406481 -1.11591000708588 45 7 0.0251798561151079 278 2226 5588,2268,5578,6850,157,5580,4846 PRKCQ,FGR,PRKCA,SYK,GRK3,PRKCD,NOS3 alk1_2pathway ALK1 pathway 0.329949120202315 -1.10881681761386 3 1 0.00359712230215827 278 2226 90 ACVR1 a4b1_a4b7_pathway a4b1 and a4b7 Integrin signaling 0.329949120202315 -1.10881681761386 3 1 0.00359712230215827 278 2226 3695 ITGB7 hnf3pathway FOXA transcription factor networks 0.329949120202315 -1.10881681761386 3 1 0.00359712230215827 278 2226 3169 FOXA1 endothelinpathway Endothelins 0.339653006623511 -1.0798307512612 53 8 0.0287769784172662 278 2226 5321,5058,112,5588,5578,23236,5580,107 PLA2G4A,PAK1,ADCY6,PRKCQ,PRKCA,PLCB1,PRKCD,ADCY1 cxcr4_pathway CXCR4-mediated signaling events 0.347629901710347 -1.05661686595828 76 11 0.039568345323741 278 2226 5788,5058,2268,5829,3655,5777,3673,6777,2870,10399,23236 PTPRC,PAK1,FGR,PXN,ITGA6,PTPN6,ITGA2,STAT5B,GRK6,RACK1,PLCB1 avb3_integrin_pathway Integrins in angiogenesis 0.349044603397592 -1.05255556151438 46 7 0.0251798561151079 278 2226 10451,5829,3480,2335,1285,1435,3690 VAV3,PXN,IGF1R,FN1,COL4A3,CSF1,ITGB3 syndecan_1_pathway Syndecan-1-mediated signaling events 0.358509340256184 -1.02580056556865 17 3 0.0107913669064748 278 2226 3082,4233,10855 HGF,MET,HPSE epha2_fwdpathway EPHA2 forward signaling 0.358509340256184 -1.02580056556865 17 3 0.0107913669064748 278 2226 5058,10451,3636 PAK1,VAV3,INPPL1 pdgfrbpathway PDGFR-beta signaling pathway 0.359594771808335 -1.02277751539933 54 8 0.0287769784172662 278 2226 2241,2268,5795,4609,5580,6777,2887,5159 FER,FGR,PTPRJ,MYC,PRKCD,STAT5B,GRB10,PDGFRB fak_pathway Signaling events mediated by focal adhesion kinase 0.359594771808335 -1.02277751539933 54 8 0.0287769784172662 278 2226 5058,23092,11279,5829,64283,9826,1793,11099 PAK1,ARHGAP26,KLF8,PXN,ARHGEF28,ARHGEF11,DOCK1,PTPN21 erbb4_pathway ErbB4 signaling events 0.369924817025113 -0.994455491220646 32 5 0.0179856115107914 278 2226 10413,685,6777,10718,4734 YAP1,BTC,STAT5B,NRG3,NEDD4 erbb1_receptor_proximal_pathway EGF receptor (ErbB1) signaling pathway 0.381681504303591 -0.963168776512951 25 4 0.0143884892086331 278 2226 5058,2934,5777,2770 PAK1,GSN,PTPN6,GNAI1 ecadherin_stabilization_pathway Stabilization and expansion of the E-cadherin adherens junction 0.382711387398083 -0.960474131576173 40 6 0.0215827338129496 278 2226 3082,55740,4646,3480,4233,4026 HGF,ENAH,MYO6,IGF1R,MET,LPP angiopoietinreceptor_pathway Angiopoietin receptor Tie2-mediated signaling 0.392282944151471 -0.935771903256573 48 7 0.0251798561151079 278 2226 5058,6777,5829,2335,2888,2242,4846 PAK1,STAT5B,PXN,FN1,GRB14,FES,NOS3 pi3kcipathway Class I PI3K signaling events 0.406344052535042 -0.900555058200992 41 6 0.0215827338129496 278 2226 6446,2268,3636,59338,9265,57580 SGK1,FGR,INPPL1,PLEKHA1,CYTH3,PREX1 tcrraspathway Ras signaling in the CD4+ TCR pathway 0.407847135123971 -0.896862843597668 11 2 0.00719424460431655 278 2226 5578,5579 PRKCA,PRKCB syndecan_pathway Proteogylcan syndecan-mediated signaling events 0.413743157354234 -0.882509890544275 4 1 0.00359712230215827 278 2226 9672 SDC3 plk_pathway Polo-like kinase signaling events in the cell cycle 0.413743157354234 -0.882509890544275 4 1 0.00359712230215827 278 2226 10769 PLK2 hif1_tfpathway HIF-1-alpha transcription factor network 0.424781517475816 -0.856180318767853 65 9 0.0323741007194245 278 2226 4088,7015,2624,226,3099,4869,664,3098,2023 SMAD3,TERT,GATA2,ALDOA,HK2,NPM1,BNIP3,HK1,ENO1 a4b1_paxdep_pathway Paxillin-dependent events mediated by a4b1 0.429885104748719 -0.844237304257137 19 3 0.0107913669064748 278 2226 3695,5829,1793 ITGB7,PXN,DOCK1 insulin_pathway Insulin Pathway 0.453326011014007 -0.791143741225582 43 6 0.0215827338129496 278 2226 6446,2887,10580,23433,2888,1978 SGK1,GRB10,SORBS1,RHOQ,GRB14,EIF4EBP1 hnf3apathway FOXA1 transcription factor network 0.453326011014007 -0.791143741225582 43 6 0.0215827338129496 278 2226 1051,80781,3169,7494,725,4774 CEBPB,COL18A1,FOXA1,XBP1,C4BPB,NFIA p38_mk2pathway p38 signaling mediated by MAPKAP kinases 0.464535668604913 -0.766716934430073 20 3 0.0107913669064748 278 2226 9261,2115,2810 MAPKAPK2,ETV1,SFN tcptp_pathway Signaling events mediated by TCPTP 0.473971548941425 -0.74660798241886 36 5 0.0179856115107914 278 2226 3082,6777,4233,1435,5159 HGF,STAT5B,MET,CSF1,PDGFRB hnf3bpathway FOXA2 and FOXA3 transcription factor networks 0.476523032059588 -0.741239221149226 44 6 0.0215827338129496 278 2226 1051,1050,3157,3169,1052,7080 CEBPB,CEBPA,HMGCS1,FOXA1,CEBPD,NKX2-1 il4_2pathway IL4-mediated signaling events 0.479937250376434 -0.734099912008329 60 8 0.0287769784172662 278 2226 1051,8660,5777,3690,604,6777,3597,2242 CEBPB,IRS2,PTPN6,ITGB3,BCL6,STAT5B,IL13RA1,FES tcrjnkpathway JNK signaling in the CD4+ TCR pathway 0.496457148975096 -0.700258105414664 13 2 0.00719424460431655 278 2226 3937,5579 LCP2,PRKCB mapktrkpathway Trk receptor signaling mediated by the MAPK pathway 0.498906057973874 -0.695337461527264 29 4 0.0143884892086331 278 2226 9261,5608,5580,4208 MAPKAPK2,MAP2K6,PRKCD,MEF2C cdc42_pathway CDC42 signaling events 0.51806157397271 -0.657661175113789 70 9 0.0323741007194245 278 2226 5058,10188,55740,5337,8476,128239,5608,2059,10458 PAK1,TNK2,ENAH,PLD1,CDC42BPA,IQGAP3,MAP2K6,EPS8,BAIAP2 ps1pathway Presenilin action in Notch and Wnt signaling 0.521989708057944 -0.65010740765796 46 6 0.0215827338129496 278 2226 4040,4609,8945,4734,22943,8321 LRP6,MYC,BTRC,NEDD4,DKK1,FZD1 a4b1_paxindep_pathway Paxillin-independent events mediated by a4b1 and a4b7 0.530839911966607 -0.633294787251006 22 3 0.0107913669064748 278 2226 3695,5829,1793 ITGB7,PXN,DOCK1 s1p_s1p4_pathway S1P4 pathway 0.537499284939903 -0.620827849325571 14 2 0.00719424460431655 278 2226 2775,2770 GNAO1,GNAI1 syndecan_4_pathway Syndecan-4-mediated signaling events 0.553933041635105 -0.590711463013971 31 4 0.0143884892086331 278 2226 2335,5578,5580,2260 FN1,PRKCA,PRKCD,FGFR1 epha_fwdpathway EPHA forward signaling 0.553933041635105 -0.590711463013971 31 4 0.0143884892086331 278 2226 2042,10451,2268,1944 EPHA3,VAV3,FGR,EFNA3 a6b1_a6b4_integrin_pathway a6b1 and a6b4 Integrin signaling 0.553933041635105 -0.590711463013971 31 4 0.0143884892086331 278 2226 4233,5578,3655,2810 MET,PRKCA,ITGA6,SFN lymphangiogenesis_pathway VEGFR3 signaling in lymphatic endothelium 0.562228537143151 -0.575846862027127 23 3 0.0107913669064748 278 2226 7424,2335,3673 VEGFC,FN1,ITGA2 foxopathway FoxO family signaling 0.565834919551238 -0.569452904890712 48 6 0.0215827338129496 278 2226 6446,1147,114907,5602,2810,604 SGK1,CHUK,FBXO32,MAPK10,SFN,BCL6 lpa4_pathway LPA4-mediated signaling events 0.57618359615257 -0.551328925753671 15 2 0.00719424460431655 278 2226 112,107 ADCY6,ADCY1 pi3kplctrkpathway Trk receptor signaling mediated by PI3K and PLC-gamma 0.580219930866438 -0.544348056167436 32 4 0.0143884892086331 278 2226 116986,7222,5580,2810 AGAP2,TRPC3,PRKCD,SFN s1p_s1p2_pathway S1P2 pathway 0.592315154842755 -0.523716429596096 24 3 0.0107913669064748 278 2226 5058,2775,2770 PAK1,GNAO1,GNAI1 ephbfwdpathway EPHB forward signaling 0.60560368081581 -0.501529498912028 33 4 0.0143884892086331 278 2226 5058,1948,5829,2047 PAK1,EFNB2,PXN,EPHB1 ecadherin_nascentaj_pathway E-cadherin signaling in the nascent adherens junction 0.60560368081581 -0.501529498912028 33 4 0.0143884892086331 278 2226 7082,3695,55740,2017 TJP1,ITGB7,ENAH,CTTN syndecan_2_pathway Syndecan-2-mediated signaling events 0.60560368081581 -0.501529498912028 33 4 0.0143884892086331 278 2226 10399,2335,5580,3673 RACK1,FN1,PRKCD,ITGA2 ar_tf_pathway Regulation of Androgen receptor activity 0.607678957062048 -0.498108567621457 50 6 0.0215827338129496 278 2226 1050,10399,5585,2624,5608,5966 CEBPA,RACK1,PKN1,GATA2,MAP2K6,REL caspase_pathway Caspase cascade in apoptosis 0.607678957062048 -0.498108567621457 50 6 0.0215827338129496 278 2226 7431,2934,6304,7020,6720,7132 VIM,GSN,SATB1,TFAP2A,SREBF1,TNFRSF1A lkb1_pathway LKB1 signaling events 0.61724846468996 -0.48248363809901 42 5 0.0179856115107914 278 2226 6604,55437,4133,4609,2810 SMARCD3,STRADB,MAP2,MYC,SFN smad2_3nuclearpathway Regulation of nuclear SMAD2/3 signaling 0.62265664791771 -0.473760039058823 76 9 0.0323741007194245 278 2226 1051,4088,860,4609,2625,467,2290,6497,4208 CEBPB,SMAD3,RUNX2,MYC,GATA3,ATF3,FOXG1,SKI,MEF2C nfat_3pathway Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.627757069178195 -0.465602019871736 51 6 0.0215827338129496 278 2226 5588,5578,9495,3164,5580,2810 PRKCQ,PRKCA,AKAP5,NR4A1,PRKCD,SFN hdac_classii_pathway Signaling events mediated by HDAC Class II 0.630037131691992 -0.461976522139767 34 4 0.0143884892086331 278 2226 5903,2624,604,4208 RANBP2,GATA2,BCL6,MEF2C pi3kciaktpathway Class I PI3K signaling events mediated by Akt 0.630037131691992 -0.461976522139767 34 4 0.0143884892086331 278 2226 1147,9882,10000,2810 CHUK,TBC1D4,AKT3,SFN il6_7pathway IL6-mediated signaling events 0.638817208594438 -0.448136924064806 43 5 0.0179856115107914 278 2226 1051,5608,4609,1052,5580 CEBPB,MAP2K6,MYC,CEBPD,PRKCD syndecan_3_pathway Syndecan-3-mediated signaling events 0.64631687799838 -0.436465372249414 17 2 0.00719424460431655 278 2226 9672,2017 SDC3,CTTN glypican_1pathway Glypican 1 network 0.648357550857212 -0.433312958788056 26 3 0.0107913669064748 278 2226 2268,9353,2260 FGR,SLIT2,FGFR1 er_nongenomic_pathway Plasma membrane estrogen receptor signaling 0.648357550857212 -0.433312958788056 26 3 0.0107913669064748 278 2226 3480,23236,4846 IGF1R,PLCB1,NOS3 faspathway FAS (CD95) signaling pathway 0.653485362773101 -0.425435144373599 35 4 0.0143884892086331 278 2226 1147,5602,5608,6850 CHUK,MAPK10,MAP2K6,SYK wnt_beta_catenin_pathway Regulation of Wnt-mediated beta catenin signaling and target gene transcription 0.654805567152185 -0.423416931456265 78 9 0.0323741007194245 278 2226 23043,83439,7015,4609,25776,2810,6591,8945,22943 TNIK,TCF7L1,TERT,MYC,CBY1,SFN,SNAI2,BTRC,DKK1 ephrina_ephapathway EphrinA-EPHA pathway 0.65665647860179 -0.420594260858178 8 1 0.00359712230215827 278 2226 2042 EPHA3 glypican_3pathway Glypican 3 network 0.65665647860179 -0.420594260858178 8 1 0.00359712230215827 278 2226 652 BMP4 arf6_traffickingpathway Arf6 trafficking events 0.659624154305894 -0.416085069340289 44 5 0.0179856115107914 278 2226 5337,1363,7253,3655,3673 PLD1,CPE,TSHR,ITGA6,ITGA2 plk1_pathway PLK1 signaling events 0.659624154305894 -0.416085069340289 44 5 0.0179856115107914 278 2226 5058,55857,8555,8945,7178 PAK1,KIZ,CDC14B,BTRC,TPT1 myc_activpathway Validated targets of C-MYC transcriptional activation 0.699994064171357 -0.356683423729891 81 9 0.0323741007194245 278 2226 4088,2597,7015,5366,4609,4869,5274,6875,2023 SMAD3,GAPDH,TERT,PMAIP1,MYC,NPM1,SERPINI1,TAF4B,ENO1 reg_gr_pathway Glucocorticoid receptor regulatory network 0.714203199747594 -0.336587763647571 82 9 0.0323741007194245 278 2226 1447,3164,2625,6446,6777,5106,5602,5567,2810 CSN2,NR4A1,GATA3,SGK1,STAT5B,PCK2,MAPK10,PRKACB,SFN trkrpathway Neurotrophic factor-mediated Trk receptor signaling 0.718744729196234 -0.330249020189662 56 6 0.0215827338129496 278 2226 5058,4916,627,1793,23263,9846 PAK1,NTRK3,BDNF,DOCK1,MCF2L,GAB2 rb_1pathway Regulation of retinoblastoma protein 0.718744729196234 -0.330249020189662 56 6 0.0215827338129496 278 2226 1051,1050,860,4233,1052,4208 CEBPB,CEBPA,RUNX2,MET,CEBPD,MEF2C lysophospholipid_pathway LPA receptor mediated events 0.721263520703218 -0.326750715126568 65 7 0.0251798561151079 278 2226 112,5829,9170,2775,5580,2770,107 ADCY6,PXN,LPAR2,GNAO1,PRKCD,GNAI1,ADCY1 vegfr1_pathway VEGFR1 specific signals 0.721781140644761 -0.326033315343169 29 3 0.0107913669064748 278 2226 8829,5578,4846 NRP1,PRKCA,NOS3 insulin_glucose_pathway Insulin-mediated glucose transport 0.721781140644761 -0.326033315343169 29 3 0.0107913669064748 278 2226 23433,9882,2810 RHOQ,TBC1D4,SFN ar_pathway Coregulation of Androgen receptor activity 0.734967754260208 -0.307928652486514 57 6 0.0215827338129496 278 2226 6840,3092,10451,26524,2934,2274 SVIL,HIP1,VAV3,LATS2,GSN,FHL2 cd40_pathway CD40/CD40L signaling 0.743445324579498 -0.296460053675012 30 3 0.0107913669064748 278 2226 958,5602,4609 CD40,MAPK10,MYC il2_stat5pathway IL2 signaling events mediated by STAT5 0.743445324579498 -0.296460053675012 30 3 0.0107913669064748 278 2226 6777,4609,9846 STAT5B,MYC,GAB2 erbb1_downstream_pathway ErbB1 downstream signaling 0.747710591065371 -0.290739286217191 102 11 0.039568345323741 278 2226 1124,9047,4609,5580,2059,5337,5578,10458,2810,1843,4208 CHN2,SH2D2A,MYC,PRKCD,EPS8,PLD1,PRKCA,BAIAP2,SFN,DUSP1,MEF2C notch_pathway Notch signaling pathway 0.750520645324299 -0.286988119527087 58 6 0.0215827338129496 278 2226 2625,2023,92737,4609,8945,1272 GATA3,ENO1,DNER,MYC,BTRC,CNTN1 s1p_meta_pathway Sphingosine 1-phosphate (S1P) pathway 0.758707269950089 -0.276139254569756 21 2 0.00719424460431655 278 2226 2775,2770 GNAO1,GNAI1 cd8tcrdownstreampathway Downstream signaling in naive CD8+ T cells 0.767715484417333 -0.264336077471098 50 5 0.0179856115107914 278 2226 5588,8320,5578,5579,6775 PRKCQ,EOMES,PRKCA,PRKCB,STAT4 ranbp2pathway Sumoylation by RanBP2 regulates transcriptional repression 0.770297787810198 -0.260978101482205 11 1 0.00359712230215827 278 2226 5903 RANBP2 cmyb_pathway C-MYB transcription factor network 0.777958892493177 -0.25108159361206 78 8 0.0287769784172662 278 2226 1051,4609,8900,2625,1050,1052,490,6497 CEBPB,MYC,CCNA1,GATA3,CEBPA,CEBPD,ATP2B1,SKI hedgehog_2pathway Signaling events mediated by the Hedgehog family 0.781494005750318 -0.246547799335156 22 2 0.00719424460431655 278 2226 8643,2619 PTCH2,GAS1 anthraxpathway Cellular roles of Anthrax toxin 0.781494005750318 -0.246547799335156 22 2 0.00719424460431655 278 2226 118429,5608 ANTXR2,MAP2K6 tgfbrpathway TGF-beta receptor signaling 0.782928355636365 -0.244714087003542 51 5 0.0179856115107914 278 2226 4088,10413,7049,100506658,9372 SMAD3,YAP1,TGFBR3,OCLN,ZFYVE9 kitpathway Signaling events mediated by Stem cell factor receptor (c-Kit) 0.797363952941856 -0.226444050798032 52 5 0.0179856115107914 278 2226 2887,2241,5287,5777,6591 GRB10,FER,PIK3C2B,PTPN6,SNAI2 epopathway EPO signaling pathway 0.800449345428814 -0.222582027212364 33 3 0.0107913669064748 278 2226 8660,6777,5777 IRS2,STAT5B,PTPN6 erbb1_internalization_pathway Internalization of ErbB1 0.816940849985724 -0.202188585781353 34 3 0.0107913669064748 278 2226 6456,57732,10253 SH3GL2,ZFYVE28,SPRY2 tnfpathway TNF receptor signaling pathway 0.819085852466102 -0.199566374656989 44 4 0.0143884892086331 278 2226 23043,1147,10399,7132 TNIK,CHUK,RACK1,TNFRSF1A hedgehog_glipathway Hedgehog signaling events mediated by Gli proteins 0.819085852466102 -0.199566374656989 44 4 0.0143884892086331 278 2226 3958,8945,5580,2735 LGALS3,BTRC,PRKCD,GLI1 il1pathway IL1-mediated signaling events 0.832264801911369 -0.18360461727048 35 3 0.0107913669064748 278 2226 1147,5608,100302736 CHUK,MAP2K6,TMED7-TICAM2 nectin_pathway Nectin adhesion pathway 0.83890204020184 -0.175661337136374 25 2 0.00719424460431655 278 2226 5159,3690 PDGFRB,ITGB3 trail_pathway TRAIL signaling pathway 0.83890204020184 -0.175661337136374 25 2 0.00719424460431655 278 2226 1147,8794 CHUK,TNFRSF10C rxr_vdr_pathway RXR and RAR heterodimerization with other nuclear receptor 0.8464151564126 -0.166745311123732 14 1 0.00359712230215827 278 2226 3164 NR4A1 il27pathway IL27-mediated signaling events 0.854780747646262 -0.15691027843203 26 2 0.00719424460431655 278 2226 2625,6775 GATA3,STAT4 nephrin_neph1_pathway Nephrin/Neph1 signaling in the kidney podocyte 0.854780747646262 -0.15691027843203 26 2 0.00719424460431655 278 2226 7082,5602 TJP1,MAPK10 il2_pi3kpathway IL2 signaling events mediated by PI3K 0.859636650690242 -0.15124547820991 37 3 0.0107913669064748 278 2226 7015,4609,9846 TERT,MYC,GAB2 foxm1pathway FOXM1 transcription factor network 0.859636650690242 -0.15124547820991 37 3 0.0107913669064748 278 2226 4609,7039,2619 MYC,TGFA,GAS1 arf6downstreampathway Arf6 downstream pathway 0.865717410719417 -0.144196739238704 15 1 0.00359712230215827 278 2226 5337 PLD1 hif1apathway Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.865717410719417 -0.144196739238704 15 1 0.00359712230215827 278 2226 10399 RACK1 nfat_tfpathway Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.868485095514259 -0.141004854629281 48 4 0.0143884892086331 278 2226 2625,5588,6520,55509 GATA3,PRKCQ,SLC3A2,BATF3 amb2_neutrophils_pathway amb2 Integrin signaling 0.868485095514259 -0.141004854629281 48 4 0.0143884892086331 278 2226 2268,2335,58494,83700 FGR,FN1,JAM2,JAM3 hes_heypathway Notch-mediated HES/HEY network 0.868485095514259 -0.141004854629281 48 4 0.0143884892086331 278 2226 3397,860,2690,23462 ID1,RUNX2,GHR,HEY1 tcrcalciumpathway Calcium signaling in the CD4+ TCR pathway 0.882338078010626 -0.125179988017174 28 2 0.00719424460431655 278 2226 9495,55509 AKAP5,BATF3 il12_stat4pathway IL12 signaling mediated by STAT4 0.882338078010626 -0.125179988017174 28 2 0.00719424460431655 278 2226 6775,8809 STAT4,IL18R1 aurora_b_pathway Aurora B signaling 0.88302556054988 -0.124401131402037 39 3 0.0107913669064748 278 2226 4869,7431,90293 NPM1,VIM,KLHL13 reelinpathway Reelin signaling pathway 0.894231184481924 -0.111790941621342 29 2 0.00719424460431655 278 2226 7436,4131 VLDLR,MAP1B rhoa_pathway RhoA signaling pathway 0.902889050857783 -0.102155600381081 41 3 0.0107913669064748 278 2226 5585,6456,5608 PKN1,SH3GL2,MAP2K6 wnt_canonical_pathway Canonical Wnt signaling pathway 0.91474307828872 -0.0891120418906569 31 2 0.00719424460431655 278 2226 4040,8945 LRP6,BTRC lis1pathway Lissencephaly gene (LIS1) in neuronal migration and development 0.91474307828872 -0.0891120418906569 31 2 0.00719424460431655 278 2226 7436,4131 VLDLR,MAP1B aurora_a_pathway Aurora A signaling 0.91474307828872 -0.0891120418906569 31 2 0.00719424460431655 278 2226 5058,64506 PAK1,CPEB1 rac1_pathway RAC1 signaling pathway 0.920775065990989 -0.0825395005781639 54 4 0.0143884892086331 278 2226 5058,128239,5608,10458 PAK1,IQGAP3,MAP2K6,BAIAP2 smad2_3pathway Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.921580789704768 -0.0816648337621346 19 1 0.00359712230215827 278 2226 4088 SMAD3 ceramide_pathway Ceramide signaling pathway 0.927024804160238 -0.0757749563198459 44 3 0.0107913669064748 278 2226 4609,5580,7132 MYC,PRKCD,TNFRSF1A bcr_5pathway BCR signaling pathway 0.930020800771787 -0.0725483266636839 66 5 0.0179856115107914 278 2226 5788,1147,5452,6850,5777 PTPRC,CHUK,POU2F2,SYK,PTPN6 cxcr3pathway CXCR3-mediated signaling events 0.938644120355204 -0.0633188701687374 34 2 0.00719424460431655 278 2226 3627,5608 CXCL10,MAP2K6 erbb2erbb3pathway ErbB2/ErbB3 signaling events 0.94509135177527 -0.0564736876152376 35 2 0.00719424460431655 278 2226 85440,5602 DOCK7,MAPK10 hivnefpathway HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.94509135177527 -0.0564736876152376 35 2 0.00719424460431655 278 2226 1147,7132 CHUK,TNFRSF1A myc_pathway C-MYC pathway 0.947648756585984 -0.0537713553132748 22 1 0.00359712230215827 278 2226 4609 MYC pdgfrapathway PDGFR-alpha signaling pathway 0.947648756585984 -0.0537713553132748 22 1 0.00359712230215827 278 2226 90525 SHF cone_pathway Visual signal transduction: Cones 0.954252044101293 -0.0468274452566106 23 1 0.00359712230215827 278 2226 9227 LRAT rhodopsin_pathway Visual signal transduction: Rods 0.954252044101293 -0.0468274452566106 23 1 0.00359712230215827 278 2226 9227 LRAT il23pathway IL23-mediated signaling events 0.956106764480532 -0.0448856938393799 37 2 0.00719424460431655 278 2226 6775,8809 STAT4,IL18R1 il12_2pathway IL12-mediated signaling events 0.957728350071237 -0.0431911006464482 61 4 0.0143884892086331 278 2226 8320,5608,6775,8809 EOMES,MAP2K6,STAT4,IL18R1 p75ntrpathway p75(NTR)-mediated signaling 0.957728350071237 -0.0431911006464482 61 4 0.0143884892086331 278 2226 1147,627,5602,27018 CHUK,BDNF,MAPK10,BEX3 hdac_classiii_pathway Signaling events mediated by HDAC Class III 0.964993977626065 -0.0356334184646298 39 2 0.00719424460431655 278 2226 10891,2274 PPARGC1A,FHL2 retinoic_acid_pathway Retinoic acid receptors-mediated signaling 0.965071841958304 -0.0355527327890526 25 1 0.00359712230215827 278 2226 5578 PRKCA ifngpathway IFN-gamma pathway 0.968763660802157 -0.0317345969408112 40 2 0.00719424460431655 278 2226 1051,5580 CEBPB,PRKCD hdac_classi_pathway Signaling events mediated by HDAC Class I 0.973566995783692 -0.0267886370373819 66 4 0.0143884892086331 278 2226 5903,2624,8945,7132 RANBP2,GATA2,BTRC,TNFRSF1A p38_mkk3_6pathway p38 MAPK signaling pathway 0.97965576782516 -0.0205540263440877 29 1 0.00359712230215827 278 2226 5608 MAP2K6 bard1pathway BARD1 signaling events 0.97965576782516 -0.0205540263440877 29 1 0.00359712230215827 278 2226 4869 NPM1 wnt_noncanonical_pathway Noncanonical Wnt signaling pathway 0.982230049373028 -0.0179297318997243 30 1 0.00359712230215827 278 2226 5602 MAPK10 fra_pathway Validated transcriptional targets of AP1 family members Fra1 and Fra2 0.989663366832199 -0.0103904271808311 34 1 0.00359712230215827 278 2226 4846 NOS3 telomerasepathway Regulation of Telomerase 0.992528755966544 -0.00749929357446926 66 3 0.0107913669064748 278 2226 4088,7015,4609 SMAD3,TERT,MYC e2f_pathway E2F transcription factor network 0.99615352947197 -0.00385388722062631 72 3 0.0107913669064748 278 2226 1050,4609,23491 CEBPA,MYC,CES3 p53regulationpathway p53 pathway 0.99669622600251 -0.00330924350881243 59 2 0.00719424460431655 278 2226 900,5580 CCNG1,PRKCD ecadherin_1_pathway E-cadherin signaling events 0.999999999996497 -3.50311793462232e-12 2 0 0 278 2226 glypican_2pathway Glypican 2 network 0.999999999996497 -3.50311793462232e-12 2 0 0 278 2226 glypicanpathway Glypican pathway 0.999999999998769 -1.23105583886562e-12 3 0 0 278 2226 aurora_kinase_pathway Signaling by Aurora kinases 0.999999999998769 -1.23105583886562e-12 3 0 0 278 2226 aurora_c_pathway Aurora C signaling 0.999999999998769 -1.23105583886562e-12 3 0 0 278 2226 ephrinarevpathway Ephrin A reverse signaling 0.999999999998769 -1.23105583886562e-12 3 0 0 278 2226 pi3kcibpathway Class IB PI3K non-lipid kinase events 0.999999999998769 -1.23105583886562e-12 3 0 0 278 2226 plk3_pathway PLK3 signaling events 1.0000000000008 7.96226925131637e-13 5 0 0 278 2226 rapid_gr_pathway Rapid glucocorticoid signaling 1.00000000000622 6.21555828703145e-12 7 0 0 278 2226 et_egfrpathway EGFR-dependent Endothelin signaling events 1.00000000000799 7.99221539593221e-12 8 0 0 278 2226 circadianpathway Circadian rhythm pathway 1.00000000001461 1.46117702165754e-11 14 0 0 278 2226 ar_nongenomic_pathway Nongenotropic Androgen signaling 1.00000000001959 1.95936710463786e-11 18 0 0 278 2226 arf_3pathway Arf1 pathway 1.00000000001959 1.95936710463786e-11 18 0 0 278 2226 ecadherin_keratinocyte_pathway E-cadherin signaling in keratinocytes 1.0000000000198 1.97979713529411e-11 19 0 0 278 2226 prlsignalingeventspathway Signaling events mediated by PRL 1.00000000002672 2.67163971019506e-11 23 0 0 278 2226 hif2pathway HIF-2-alpha transcription factor network 1.00000000003187 3.18709467117024e-11 34 0 0 278 2226