TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-HSA-112316 Neuronal System 9.63498056840814e-09 -18.4578655518535 349 67 0.0690010298661174 971 10287 10368,9495,2898,91683,57596,18,9378,5578,785,23136,6196,10497,3781,7881,1138,8499,3790,8825,5567,9312,27133,22941,107,8973,57502,3752,10052,2770,27345,5579,5924,59345,3755,4128,5802,321,27012,55970,5789,2561,2566,6507,2570,320,3749,3761,590,783,27094,112,23426,4646,6812,9229,57669,217,3786,777,9455,8497,6616,23236,9454,2900,1740,2906,781 CACNG3,AKAP5,GRIK2,SYT12,BEGAIN,ABAT,NRXN1,PRKCA,CACNB4,EPB41L3,RPS6KA2,UNC13B,KCNN2,KCNAB1,CHRNA5,PPFIA2,KCNS3,LIN7A,PRKACB,KCNB2,KCNH5,SHANK2,ADCY1,CHRNA6,NLGN4X,KCND3,GJC1,GNAI1,KCNMB4,PRKCB,RASGRF2,GNB4,KCNG1,MAOA,PTPRS,APBA2,KCNV1,GNG12,PTPRD,GABRB2,GABRG2,SLC1A3,GABRR2,APBA1,KCNC4,KCNJ4,BCHE,CACNB2,KCNMB3,ADCY6,GRIP1,MYO6,STXBP1,DLGAP1,EPB41L5,ALDH2,KCNQ3,CACNA1E,HOMER2,PPFIA4,SNAP25,PLCB1,HOMER3,GRIK4,DLG2,GRIN2D,CACNA2D1 R-HSA-422475 Axon guidance 3.44765328999204e-07 -14.8804018571594 549 88 0.0906282183316169 971 10287 2042,685,26052,9462,1850,1793,5362,55740,5578,785,57556,6196,3690,7220,153090,2051,6326,4233,9353,10125,5567,6328,5159,9846,1292,51466,1285,1630,10486,287,5588,8822,2260,8660,10718,5924,3912,3673,2887,3082,219699,8829,1272,1948,1299,6331,6092,2335,9826,57144,6334,1287,2047,5217,55816,4756,3983,6324,783,57522,4684,2674,1298,2242,1843,2264,5058,56896,9260,54756,8633,10451,64283,3786,4651,9693,1286,1944,1852,22821,116986,5788,6456,2906,399473,7222,10371,57698 EPHA3,BTC,DNM3,RASAL2,DUSP8,DOCK1,PLXNA2,ENAH,PRKCA,CACNB4,SEMA6A,RPS6KA2,ITGB3,TRPC1,DAB2IP,EPHB6,SCN2A,MET,SLIT2,RASGRP1,PRKACB,SCN3A,PDGFRB,GAB2,COL6A2,EVL,COL4A3,DCC,CAP2,ANK2,PRKCQ,FGF17,FGFR1,IRS2,NRG3,RASGRF2,LAMB1,ITGA2,GRB10,HGF,UNC5B,NRP1,CNTN1,EFNB2,COL9A3,SCN5A,ROBO2,FN1,ARHGEF11,PAK5,SCN8A,COL4A5,EPHB1,PFN2,DOK5,NEO1,ABLIM1,SCN1B,CACNB2,SRGAP1,NCAM1,GFRA1,COL9A2,FES,DUSP1,FGFR4,PAK1,DPYSL5,PDLIM7,IL17RD,UNC5C,VAV3,ARHGEF28,KCNQ3,MYO10,RAPGEF2,COL4A4,EFNA3,DUSP9,RASA3,AGAP2,PTPRC,SH3GL2,GRIN2D,SPRED3,TRPC3,SEMA3A,SHTN1 R-HSA-1650814 Collagen biosynthesis and modifying enzymes 1.02931038403235e-06 -13.7866215100238 70 21 0.0216271884654995 971 10287 1299,1292,1285,1286,23127,80781,1287,7373,85301,169044,5352,9508,84570,8974,649,5033,1310,26577,871,1298,7093 COL9A3,COL6A2,COL4A3,COL4A4,COLGALT2,COL18A1,COL4A5,COL14A1,COL27A1,COL22A1,PLOD2,ADAMTS3,COL25A1,P4HA2,BMP1,P4HA1,COL19A1,PCOLCE2,SERPINH1,COL9A2,TLL2 R-HSA-1474290 Collagen formation 3.56838865685632e-06 -12.5433964206877 93 24 0.0247167868177137 971 10287 1299,1292,1285,1286,3655,23127,80781,1287,7373,85301,169044,9508,5352,84570,8974,1515,649,5033,1310,26577,84171,871,1298,7093 COL9A3,COL6A2,COL4A3,COL4A4,ITGA6,COLGALT2,COL18A1,COL4A5,COL14A1,COL27A1,COL22A1,ADAMTS3,PLOD2,COL25A1,P4HA2,CTSV,BMP1,P4HA1,COL19A1,PCOLCE2,LOXL4,SERPINH1,COL9A2,TLL2 R-HSA-112315 Transmission across Chemical Synapses 2.59008348653136e-05 -10.5612353555963 217 40 0.0411946446961895 971 10287 55970,10368,9495,2898,2561,2566,18,2570,6507,320,5578,785,3761,6196,10497,1138,590,783,8499,8825,112,23426,4646,6812,5567,217,777,107,8973,8497,6616,23236,2770,2900,5579,59345,5924,4128,2906,781 GNG12,CACNG3,AKAP5,GRIK2,GABRB2,GABRG2,ABAT,GABRR2,SLC1A3,APBA1,PRKCA,CACNB4,KCNJ4,RPS6KA2,UNC13B,CHRNA5,BCHE,CACNB2,PPFIA2,LIN7A,ADCY6,GRIP1,MYO6,STXBP1,PRKACB,ALDH2,CACNA1E,ADCY1,CHRNA6,PPFIA4,SNAP25,PLCB1,GNAI1,GRIK4,PRKCB,GNB4,RASGRF2,MAOA,GRIN2D,CACNA2D1 R-HSA-191273 Cholesterol biosynthesis 3.0623670887782e-05 -10.3937372896238 24 10 0.0102986611740474 971 10287 1595,3422,4598,3157,6307,4597,1718,6713,1717,3156 CYP51A1,IDI1,MVK,HMGCS1,MSMO1,MVD,DHCR24,SQLE,DHCR7,HMGCR R-HSA-6794361 Interactions of neurexins and neuroligins at synapses 6.20710661888079e-05 -9.68723060048618 58 16 0.0164778578784758 971 10287 9229,57669,91683,22941,9455,57596,57502,9378,320,9454,23136,8825,1740,2906,6812,321 DLGAP1,EPB41L5,SYT12,SHANK2,HOMER2,BEGAIN,NLGN4X,NRXN1,APBA1,HOMER3,EPB41L3,LIN7A,DLG2,GRIN2D,STXBP1,APBA2 R-HSA-6794362 Protein-protein interactions at synapses 9.09913730263609e-05 -9.30474585784953 72 18 0.0185375901132853 971 10287 9229,57669,5789,91683,22941,9455,57596,57502,320,9378,9454,23136,8825,5802,2906,1740,321,6812 DLGAP1,EPB41L5,PTPRD,SYT12,SHANK2,HOMER2,BEGAIN,NLGN4X,APBA1,NRXN1,HOMER3,EPB41L3,LIN7A,PTPRS,GRIN2D,DLG2,APBA2,STXBP1 R-HSA-422356 Regulation of insulin secretion 0.000123241044693608 -9.00136840736807 80 19 0.01956745623069 971 10287 55970,9495,777,11069,402,5577,3709,6616,5578,23236,2770,59345,783,3790,112,4082,6812,1131,5567 GNG12,AKAP5,CACNA1E,RAPGEF4,ARL2,PRKAR2B,ITPR2,SNAP25,PRKCA,PLCB1,GNAI1,GNB4,CACNB2,KCNS3,ADCY6,MARCKS,STXBP1,CHRM3,PRKACB R-HSA-1474244 Extracellular matrix organization 0.000127596366165449 -8.9666386657863 296 48 0.0494335736354274 971 10287 1299,2335,3655,4038,10319,80781,1287,9378,63827,5578,780,7373,85301,2202,169044,84570,3690,1310,85007,84171,26577,871,4684,58494,1298,3695,1292,1285,1286,726,23127,9672,83700,4324,9508,2200,5352,8974,1515,3673,3912,649,5033,5802,652,50859,4325,7093 COL9A3,FN1,ITGA6,LRP4,LAMC3,COL18A1,COL4A5,NRXN1,BCAN,PRKCA,DDR1,COL14A1,COL27A1,EFEMP1,COL22A1,COL25A1,ITGB3,COL19A1,PHYKPL,LOXL4,PCOLCE2,SERPINH1,NCAM1,JAM2,COL9A2,ITGB7,COL6A2,COL4A3,COL4A4,CAPN5,COLGALT2,SDC3,JAM3,MMP15,ADAMTS3,FBN1,PLOD2,P4HA2,CTSV,ITGA2,LAMB1,BMP1,P4HA1,PTPRS,BMP4,SPOCK3,MMP16,TLL2 R-HSA-373752 Netrin-1 signaling 0.00035629761653484 -7.9397441748645 42 12 0.0123583934088568 971 10287 8633,3983,1793,4651,1630,7220,5588,116986,219699,7222,9353,4756 UNC5C,ABLIM1,DOCK1,MYO10,DCC,TRPC1,PRKCQ,AGAP2,UNC5B,TRPC3,SLIT2,NEO1 R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.00035629761653484 -7.9397441748645 42 12 0.0123583934088568 971 10287 1595,3422,4598,3157,4597,6720,2194,6604,6713,6319,1717,3156 CYP51A1,IDI1,MVK,HMGCS1,MVD,SREBF1,FASN,SMARCD3,SQLE,SCD,DHCR7,HMGCR R-HSA-352230 Amino acid transport across the plasma membrane 0.000375041280200547 -7.88847445751749 31 10 0.0102986611740474 971 10287 6541,6520,23657,206358,8140,55117,6542,6510,117247,8501 SLC7A1,SLC3A2,SLC7A11,SLC36A1,SLC7A5,SLC6A15,SLC7A2,SLC1A5,SLC16A10,SLC43A1 R-HSA-2028269 Signaling by Hippo 0.000406569411794305 -7.8077558888318 21 8 0.0082389289392379 971 10287 10413,23286,92597,26524,7082,154810,60485,25937 YAP1,WWC1,MOB1B,LATS2,TJP1,AMOTL1,SAV1,WWTR1 R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.00044139495523896 -7.72557049320795 55 14 0.0144181256436663 971 10287 1595,3422,4598,3157,3638,9871,4597,6720,2194,6604,6713,6319,1717,3156 CYP51A1,IDI1,MVK,HMGCS1,INSIG1,SEC24D,MVD,SREBF1,FASN,SMARCD3,SQLE,SCD,DHCR7,HMGCR R-HSA-163685 Integration of energy metabolism 0.000598452425557942 -7.42116352558612 111 22 0.0226570545829042 971 10287 5563,55970,9495,777,11069,107,2194,402,5577,3709,6616,5578,23236,2770,783,59345,3790,112,4082,6812,1131,5567 PRKAA2,GNG12,AKAP5,CACNA1E,RAPGEF4,ADCY1,FASN,ARL2,PRKAR2B,ITPR2,SNAP25,PRKCA,PLCB1,GNAI1,CACNB2,GNB4,KCNS3,ADCY6,MARCKS,STXBP1,CHRM3,PRKACB R-HSA-194840 Rho GTPase cycle 0.000800183952177748 -7.13066891650636 143 26 0.0267765190525232 971 10287 23092,10451,116984,23433,9826,9886,29984,58504,57580,4983,84033,9743,10144,5881,26230,9912,26084,84144,55160,1123,57584,1124,23263,5924,57522,79822 ARHGAP26,VAV3,ARAP2,RHOQ,ARHGEF11,RHOBTB1,RHOD,ARHGAP22,PREX1,OPHN1,OBSCN,ARHGAP32,FAM13A,RAC3,TIAM2,ARHGAP44,ARHGEF26,SYDE2,ARHGEF10L,CHN1,ARHGAP21,CHN2,MCF2L,RASGRF2,SRGAP1,ARHGAP28 R-HSA-109582 Hemostasis 0.00104875088710777 -6.86015545431168 632 83 0.0854788877445932 971 10287 5321,5153,1793,3798,3512,2625,3709,23046,3937,1795,5578,57406,1794,5099,2152,4072,3690,5627,5874,10125,5567,81704,9846,6520,10257,5777,5577,5588,481,2161,5919,80005,83700,2770,27345,2995,5579,59345,226,3673,3082,55970,2335,2888,3655,6402,3046,5028,2621,6414,23657,2624,10846,30845,5580,5592,27094,5593,58494,6850,490,4846,7424,5768,3048,10451,11069,9672,9749,23414,2977,747,2268,85440,5547,10000,8140,55605,7222,57572,23095,493,23348 PLA2G4A,PDE1B,DOCK1,KIF5A,JCHAIN,GATA3,ITPR2,KIF21B,LCP2,DOCK3,PRKCA,ABHD6,DOCK2,PCDH7,F3,EPCAM,ITGB3,PROS1,RAB27B,RASGRP1,PRKACB,DOCK8,GAB2,SLC3A2,ABCC4,PTPN6,PRKAR2B,PRKCQ,ATP1B1,F12,RARRES2,DOCK5,JAM3,GNAI1,KCNMB4,GYPC,PRKCB,GNB4,ALDOA,ITGA2,HGF,GNG12,FN1,GRB14,ITGA6,SELL,HBE1,P2RY1,GAS6,SELENOP,SLC7A11,GATA2,PDE10A,EHD3,PRKCD,PRKG1,KCNMB3,PRKG2,JAM2,SYK,ATP2B1,NOS3,VEGFC,QSOX1,HBG2,VAV3,RAPGEF4,SDC3,PHACTR2,ZFPM2,GUCY1A2,DAGLA,FGR,DOCK7,PRCP,AKT3,SLC7A5,KIF21A,TRPC3,DOCK6,KIF1B,ATP2B4,DOCK9 R-HSA-8948216 Collagen chain trimerization 0.00108260912266917 -6.82838129700733 47 12 0.0123583934088568 971 10287 169044,1299,1292,1285,84570,1286,80781,1310,1287,7373,1298,85301 COL22A1,COL9A3,COL6A2,COL4A3,COL25A1,COL4A4,COL18A1,COL19A1,COL4A5,COL14A1,COL9A2,COL27A1 R-HSA-112043 PLC beta mediated events 0.00108260912266917 -6.82838129700733 47 12 0.0123583934088568 971 10287 5321,5153,2775,5580,107,112,5577,3709,5578,23236,5567,2770 PLA2G4A,PDE1B,GNAO1,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PRKCA,PLCB1,PRKACB,GNAI1 R-HSA-201451 Signaling by BMP 0.00113710790557047 -6.7792671649609 24 8 0.0082389289392379 971 10287 4093,659,91851,92,657,93,4091,6497 SMAD9,BMPR2,CHRDL1,ACVR2A,BMPR1A,ACVR2B,SMAD6,SKI R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.00113710790557047 -6.7792671649609 24 8 0.0082389289392379 971 10287 27345,5153,10846,27094,5592,5593,2977,4846 KCNMB4,PDE1B,PDE10A,KCNMB3,PRKG1,PRKG2,GUCY1A2,NOS3 R-HSA-112040 G-protein mediated events 0.00132175385430051 -6.62879574679433 48 12 0.0123583934088568 971 10287 5321,5153,2775,5580,107,112,5577,3709,5578,23236,5567,2770 PLA2G4A,PDE1B,GNAO1,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PRKCA,PLCB1,PRKACB,GNAI1 R-HSA-419037 NCAM1 interactions 0.0017469970349587 -6.34985694505049 37 10 0.0102986611740474 971 10287 1299,1292,1285,783,1286,1287,4684,785,2674,1298 COL9A3,COL6A2,COL4A3,CACNB2,COL4A4,COL4A5,NCAM1,CACNB4,GFRA1,COL9A2 R-HSA-70171 Glycolysis 0.00217846987553184 -6.1291325405805 32 9 0.00926879505664264 971 10287 5210,2597,3098,2026,2023,5208,230,226,3099 PFKFB4,GAPDH,HK1,ENO2,ENO1,PFKFB2,ALDOC,ALDOA,HK2 R-HSA-376176 Signaling by Robo receptor 0.00217846987553184 -6.1291325405805 32 9 0.00926879505664264 971 10287 5058,51466,6092,57144,10486,57522,55740,5217,9353 PAK1,EVL,ROBO2,PAK5,CAP2,SRGAP1,ENAH,PFN2,SLIT2 R-HSA-373760 L1CAM interactions 0.00259159308559831 -5.95548250139701 101 19 0.01956745623069 971 10287 5058,6331,26052,3786,287,6334,2260,6196,6456,6324,3673,3912,3690,6326,8829,4684,6328,57698,1272 PAK1,SCN5A,DNM3,KCNQ3,ANK2,SCN8A,FGFR1,RPS6KA2,SH3GL2,SCN1B,ITGA2,LAMB1,ITGB3,SCN2A,NRP1,NCAM1,SCN3A,SHTN1,CNTN1 R-HSA-111465 Apoptotic cleavage of cellular proteins 0.00268090927101952 -5.92159926177073 39 10 0.0102986611740474 971 10287 2934,1829,5580,5588,7082,7431,6304,1832,8428,100506658 GSN,DSG2,PRKCD,PRKCQ,TJP1,VIM,SATB1,DSP,STK24,OCLN R-HSA-397014 Muscle contraction 0.00279460415093662 -5.88006480997708 204 32 0.0329557157569516 971 10287 6331,30818,10580,5829,10368,2258,6334,2257,6262,7431,10174,3709,3752,481,785,444,60598,3761,6324,783,25937,59,7220,29767,6326,7168,4703,493,781,490,6328,478 SCN5A,KCNIP3,SORBS1,PXN,CACNG3,FGF13,SCN8A,FGF12,RYR2,VIM,SORBS3,ITPR2,KCND3,ATP1B1,CACNB4,ASPH,KCNK15,KCNJ4,SCN1B,CACNB2,WWTR1,ACTA2,TRPC1,TMOD2,SCN2A,TPM1,NEB,ATP2B4,CACNA2D1,ATP2B1,SCN3A,ATP1A3 R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.00338004525980627 -5.68986617910163 60 13 0.0133882595262616 971 10287 1299,1292,1285,1286,3655,1515,649,80781,1287,84171,1298,85301,7093 COL9A3,COL6A2,COL4A3,COL4A4,ITGA6,CTSV,BMP1,COL18A1,COL4A5,LOXL4,COL9A2,COL27A1,TLL2 R-HSA-5576891 Cardiac conduction 0.00343106451404992 -5.6748847120037 142 24 0.0247167868177137 971 10287 6331,30818,10368,2258,6334,2257,6262,3709,3752,481,785,444,60598,3761,6324,783,25937,7220,6326,6328,781,490,493,478 SCN5A,KCNIP3,CACNG3,FGF13,SCN8A,FGF12,RYR2,ITPR2,KCND3,ATP1B1,CACNB4,ASPH,KCNK15,KCNJ4,SCN1B,CACNB2,WWTR1,TRPC1,SCN2A,SCN3A,CACNA2D1,ATP2B1,ATP2B4,ATP1A3 R-HSA-5576892 Phase 0 - rapid depolarisation 0.00363348625992048 -5.61756268941453 47 11 0.0113285272914521 971 10287 6331,10368,2258,6324,783,6334,2257,6326,785,781,6328 SCN5A,CACNG3,FGF13,SCN1B,CACNB2,SCN8A,FGF12,SCN2A,CACNB4,CACNA2D1,SCN3A R-HSA-977347 Serine biosynthesis 0.00404789675209493 -5.50955785322766 8 4 0.00411946446961895 971 10287 256987,26227,5723,347735 SERINC5,PHGDH,PSPH,SERINC2 R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.00414217308007162 -5.48653473028796 23 7 0.00720906282183316 971 10287 8497,8825,6616,10497,320,6812,8499 PPFIA4,LIN7A,SNAP25,UNC13B,APBA1,STXBP1,PPFIA2 R-HSA-418597 G alpha (z) signalling events 0.00432075805623359 -5.44432441614023 48 11 0.0113285272914521 971 10287 26575,55970,5579,59345,5580,107,8601,112,5588,5578,2770 RGS17,GNG12,PRKCB,GNB4,PRKCD,ADCY1,RGS20,ADCY6,PRKCQ,PRKCA,GNAI1 R-HSA-418346 Platelet homeostasis 0.00457872007559821 -5.38633577938849 91 17 0.0175077239958805 971 10287 5321,55970,5153,5777,3709,2977,27345,2268,59345,10846,5592,27094,5593,7222,490,493,4846 PLA2G4A,GNG12,PDE1B,PTPN6,ITPR2,GUCY1A2,KCNMB4,FGR,GNB4,PDE10A,PRKG1,KCNMB3,PRKG2,TRPC3,ATP2B1,ATP2B4,NOS3 R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.00478262060991787 -5.34276663795733 18 6 0.00617919670442842 971 10287 8497,4128,6616,10497,6812,8499 PPFIA4,MAOA,SNAP25,UNC13B,STXBP1,PPFIA2 R-HSA-418457 cGMP effects 0.00478262060991787 -5.34276663795733 18 6 0.00617919670442842 971 10287 5593,27345,5153,10846,27094,5592 PRKG2,KCNMB4,PDE1B,PDE10A,KCNMB3,PRKG1 R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.00493454846245841 -5.31149410725171 146 24 0.0247167868177137 971 10287 55970,10368,9495,2898,2561,107,2566,8973,2570,5578,23236,2770,2900,3761,6196,1138,5579,5924,59345,112,23426,2906,4646,5567 GNG12,CACNG3,AKAP5,GRIK2,GABRB2,ADCY1,GABRG2,CHRNA6,GABRR2,PRKCA,PLCB1,GNAI1,GRIK4,KCNJ4,RPS6KA2,CHRNA5,PRKCB,RASGRF2,GNB4,ADCY6,GRIP1,GRIN2D,MYO6,PRKACB R-HSA-71240 Tryptophan catabolism 0.00500527050734333 -5.29726382025422 13 5 0.00514933058702369 971 10287 6520,51166,6999,8564,8140 SLC3A2,AADAT,TDO2,KMO,SLC7A5 R-HSA-111996 Ca-dependent events 0.00543668739223504 -5.21458533884157 30 8 0.0082389289392379 971 10287 5321,5153,5580,107,112,5577,5578,5567 PLA2G4A,PDE1B,PRKCD,ADCY1,ADCY6,PRKAR2B,PRKCA,PRKACB R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 0.00724685570091583 -4.92718760061445 5 3 0.00308959835221421 971 10287 10765,4609,7020 KDM5B,MYC,TFAP2A R-HSA-1430728 Metabolism 0.0073877523807196 -4.90793173362269 2158 234 0.240988671472709 971 10287 349565,7368,4598,2180,161823,10157,7358,3949,79626,445,3709,79094,5578,63827,63874,23475,1595,1890,51166,29841,158584,3790,4714,347735,2947,5360,2023,5567,2731,1545,6520,160428,284161,8612,9200,10413,5577,81894,59338,10082,377677,2770,5831,57491,5167,203,10855,3638,133121,57089,59345,226,56898,649,5287,22876,92126,10891,51084,266722,5125,10090,5563,84706,55034,55970,3636,241,1962,9871,1573,79993,55301,1718,285440,9481,6319,51477,22856,26227,122622,23521,760,6307,590,783,6205,6720,222537,112,9443,57552,55711,6812,178,6228,29967,1131,4846,3156,337876,3992,6154,4860,84725,11001,2948,4259,7436,11069,2194,2274,6604,9672,64077,10577,6616,23236,144193,26035,9261,6158,119391,84879,3099,6713,5337,1717,114880,79646,270,6296,5321,170685,6785,9495,54947,54477,64131,64900,83594,10560,26230,1592,1040,8611,3422,440,8564,230,2172,134429,10840,4082,51121,2628,1491,57110,6207,8875,2597,5163,7390,5208,51700,4597,53354,107,9446,64850,27010,953,5903,6999,10400,25937,8821,4128,3248,113612,9953,129642,5723,6224,23324,256987,2026,23464,645,875,402,3628,81544,6164,3157,8435,5593,85007,79603,9896,5106,2098,85414,9331,5046,23491,83666,5210,26873,2946,217,123688,5783,56895,777,6144,83401,205,4141,9227,57761,23576,6136,340485,79644,114879,8140,6206,3098,6124,10715,9536,11285,9619 NMNAT3,UGT8,MVK,ACSL1,ADAL,AASS,UGDH,LDLR,TNFAIP8L2,ASS1,ITPR2,CHAC1,PRKCA,BCAN,ABHD4,QPRT,CYP51A1,TYMP,AADAT,GRHL1,FAAH2,KCNS3,NDUFB8,SERINC2,GSTM3,PLTP,ENO1,PRKACB,GLDC,CYP1B1,SLC3A2,ALDH1L2,GDPD1,PLPP2,HACD1,YAP1,PRKAR2B,SLC25A28,PLEKHA1,GPC6,CA13,GNAI1,PYCR1,AHRR,ENPP1,AK1,HPSE,INSIG1,ENPP6,ENTPD7,GNB4,ALDOA,BDH2,BMP1,PIK3C2B,INPP5F,DSEL,PPARGC1A,CRYL1,HS6ST3,PCSK5,UST,PRKAA2,GPT2,MOCOS,GNG12,INPPL1,ALOX5AP,EHHADH,SEC24D,CYP2J2,ELOVL7,OLAH,DHCR24,CYP4V2,SLC25A27,SCD,ISYNA1,CHSY1,PHGDH,ADSSL1,RPL13A,CA2,MSMO1,BCHE,CACNB2,RPS11,SREBF1,HS3ST5,ADCY6,MED7,NCEH1,FAR2,STXBP1,AGL,RPS23,LRP12,CHRM3,NOS3,HMGCR,CHSY3,FADS1,RPL26,PNP,PLEKHA8,SLC27A2,GSTM4,MGST3,VLDLR,RAPGEF4,FASN,FHL2,SMARCD3,SDC3,LHPP,NPC2,SNAP25,PLCB1,AMDHD1,GLCE,MAPKAPK2,RPL28,GSTO2,MFSD2A,HK2,SQLE,PLD1,DHCR7,OSBPL6,PANK3,AMPD1,ACSM3,PLA2G4A,NUDT10,ELOVL4,AKAP5,LPCAT2,PLEKHA5,XYLT1,LPIN3,NUDT12,SLC19A2,TIAM2,CYP26A1,CDS1,PLPP1,IDI1,ASNS,KMO,ALDOC,FABP6,STARD4,ALDH1L1,MARCKS,RPL26L1,GATM,CTH,HRASLS,RPS13,VNN2,GAPDH,PDK1,UROS,PFKFB2,CYB5R2,MVD,PANK1,ADCY1,GSTO1,ETNPPL,TPK1,ENTPD1,RANBP2,TDO2,PEMT,WWTR1,INPP4B,MAOA,HPGD,CYP2U1,HS3ST3B1,MBOAT2,PSPH,RPS20,MAN2B2,SERINC5,ENO2,GCAT,BLVRB,CBS,ARL2,INPP1,GDPD5,RPL34,HMGCS1,SOAT2,PRKG2,PHYKPL,CERS4,FIG4,PCK2,ESD,SLC45A3,B4GALT6,PCSK6,CES3,PARP9,PFKFB4,OPLAH,GSTM2,ALDH2,HYKK,PTPN13,AGPAT4,CACNA1E,RPL21,ELOVL3,AK4,MARS,LRAT,TRIB3,DDAH1,RPL12,ACER2,SRD5A3,OSBPL5,SLC7A5,RPS12,HK1,RPL4,CERS1,PTGES,B4GALT7,ABCG1 R-HSA-156590 Glutathione conjugation 0.00757518751548022 -4.88287717337425 38 9 0.00926879505664264 971 10287 26873,2946,119391,4259,2948,2947,9446,79094,2098 OPLAH,GSTM2,GSTO2,MGST3,GSTM4,GSTM3,GSTO1,CHAC1,ESD R-HSA-1614603 Cysteine formation from homocysteine 0.00890134644544796 -4.72155272768123 2 2 0.00205973223480947 971 10287 875,1491 CBS,CTH R-HSA-380612 Metabolism of serotonin 0.00890134644544796 -4.72155272768123 2 2 0.00205973223480947 971 10287 4128,217 MAOA,ALDH2 R-HSA-216083 Integrin cell surface interactions 0.0101626388628004 -4.58903713996536 68 13 0.0133882595262616 971 10287 1299,3695,1285,2335,2200,1286,3655,3690,3673,80781,58494,1298,83700 COL9A3,ITGB7,COL4A3,FN1,FBN1,COL4A4,ITGA6,ITGB3,ITGA2,COL18A1,JAM2,COL9A2,JAM3 R-HSA-399997 Acetylcholine regulates insulin secretion 0.0104112420189636 -4.56486909329314 10 4 0.00411946446961895 971 10287 4082,5578,23236,1131 MARCKS,PRKCA,PLCB1,CHRM3 R-HSA-4086398 Ca2+ pathway 0.0105887376120667 -4.54796433213381 61 12 0.0123583934088568 971 10287 55970,83439,8322,59345,2775,5592,5593,192670,7481,3709,5578,23236 GNG12,TCF7L1,FZD4,GNB4,GNAO1,PRKG1,PRKG2,AGO4,WNT11,ITPR2,PRKCA,PLCB1 R-HSA-114508 Effects of PIP2 hydrolysis 0.0107557405090217 -4.53231566609695 27 7 0.00720906282183316 971 10287 747,5588,3709,7222,57406,10125,5580 DAGLA,PRKCQ,ITPR2,TRPC3,ABHD6,RASGRP1,PRKCD R-HSA-194138 Signaling by VEGF 0.0110542795566591 -4.50493763580047 338 45 0.0463439752832132 971 10287 10810,685,2335,9462,1850,1793,3709,5578,5580,3690,153090,4684,4233,2674,10125,5567,5159,4846,1843,2264,5058,7424,54756,10451,5829,9047,9693,1852,22821,8822,2260,10458,9261,8660,57761,10718,3071,5579,5924,10000,2906,3082,5603,399473,8829 WASF3,BTC,FN1,RASAL2,DUSP8,DOCK1,ITPR2,PRKCA,PRKCD,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PRKACB,PDGFRB,NOS3,DUSP1,FGFR4,PAK1,VEGFC,IL17RD,VAV3,PXN,SH2D2A,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,BAIAP2,MAPKAPK2,IRS2,TRIB3,NRG3,NCKAP1L,PRKCB,RASGRF2,AKT3,GRIN2D,HGF,MAPK13,SPRED3,NRP1 R-HSA-1266738 Developmental Biology 0.0115609597150642 -4.46012139884963 1075 123 0.126673532440783 971 10287 2042,685,26052,10368,9462,1850,6768,1793,5362,5318,55740,1050,5578,785,57556,1496,55203,6196,23254,3690,92,7220,153090,2051,6326,4233,9353,10125,64065,5567,6328,5159,9846,1292,51466,1285,130399,2649,1630,10486,287,100271849,5588,93,8822,1832,2260,4088,8660,10718,5924,3912,3673,688,2887,3082,219699,8829,10891,1272,4208,1948,1299,6331,6092,2335,9826,57144,6334,1287,2047,5217,11005,55816,4756,4825,3983,6324,783,1829,6720,57522,9443,4684,1298,2674,1052,2242,5046,1843,2264,56896,9260,5058,54756,10451,8633,64283,3786,4651,3174,9693,1286,1944,1852,6604,22821,9935,116986,3198,1051,5788,1879,6456,10000,5608,7703,2906,399473,1000,7222,10371,57698 EPHA3,BTC,DNM3,CACNG3,RASAL2,DUSP8,ST14,DOCK1,PLXNA2,PKP2,ENAH,CEBPA,PRKCA,CACNB4,SEMA6A,CTNNA2,LGI2,RPS6KA2,KAZN,ITGB3,ACVR2A,TRPC1,DAB2IP,EPHB6,SCN2A,MET,SLIT2,RASGRP1,PERP,PRKACB,SCN3A,PDGFRB,GAB2,COL6A2,EVL,COL4A3,ACVR1C,NR6A1,DCC,CAP2,ANK2,MEF2B,PRKCQ,ACVR2B,FGF17,DSP,FGFR1,SMAD3,IRS2,NRG3,RASGRF2,LAMB1,ITGA2,KLF5,GRB10,HGF,UNC5B,NRP1,PPARGC1A,CNTN1,MEF2C,EFNB2,COL9A3,SCN5A,ROBO2,FN1,ARHGEF11,PAK5,SCN8A,COL4A5,EPHB1,PFN2,SPINK5,DOK5,NEO1,NKX6-1,ABLIM1,SCN1B,CACNB2,DSG2,SREBF1,SRGAP1,MED7,NCAM1,COL9A2,GFRA1,CEBPD,FES,PCSK6,DUSP1,FGFR4,DPYSL5,PDLIM7,PAK1,IL17RD,VAV3,UNC5C,ARHGEF28,KCNQ3,MYO10,HNF4G,RAPGEF2,COL4A4,EFNA3,DUSP9,SMARCD3,RASA3,MAFB,AGAP2,HOXA1,CEBPB,PTPRC,EBF1,SH3GL2,AKT3,MAP2K6,PCGF2,GRIN2D,SPRED3,CDH2,TRPC3,SEMA3A,SHTN1 R-HSA-1489509 DAG and IP3 signaling 0.01203948382601 -4.41956371161433 34 8 0.0082389289392379 971 10287 5153,5580,107,112,5577,3709,5578,5567 PDE1B,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PRKCA,PRKACB R-HSA-111885 Opioid Signalling 0.012596616942111 -4.37432699773424 85 15 0.0154479917610711 971 10287 5321,55970,5153,59345,2775,5580,107,112,5577,3709,5144,5578,23236,5567,2770 PLA2G4A,GNG12,PDE1B,GNB4,GNAO1,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PDE4D,PRKCA,PLCB1,PRKACB,GNAI1 R-HSA-111933 Calmodulin induced events 0.0132010696766692 -4.32745741656176 28 7 0.00720906282183316 971 10287 112,5577,5153,5578,5580,5567,107 ADCY6,PRKAR2B,PDE1B,PRKCA,PRKCD,PRKACB,ADCY1 R-HSA-111997 CaM pathway 0.0132010696766692 -4.32745741656176 28 7 0.00720906282183316 971 10287 112,5577,5153,5578,5580,5567,107 ADCY6,PRKAR2B,PDE1B,PRKCA,PRKCD,PRKACB,ADCY1 R-HSA-399956 CRMPs in Sema3A signaling 0.0133787662613747 -4.31408643620349 16 5 0.00514933058702369 971 10287 56896,8829,10371,2242,5362 DPYSL5,NRP1,SEMA3A,FES,PLXNA2 R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.0133787662613747 -4.31408643620349 16 5 0.00514933058702369 971 10287 5058,8829,10371,2242,5362 PAK1,NRP1,SEMA3A,FES,PLXNA2 R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.0147473531412859 -4.21669166034745 42 9 0.00926879505664264 971 10287 55970,9495,59345,11069,3790,112,5577,3709,5567 GNG12,AKAP5,GNB4,RAPGEF4,KCNS3,ADCY6,PRKAR2B,ITPR2,PRKACB R-HSA-556833 Metabolism of lipids and lipoproteins 0.0150136938571693 -4.19879257053014 813 95 0.0978372811534501 971 10287 5321,7368,4598,2180,6785,54947,54477,3949,79626,64900,63874,26230,1040,1595,8611,3422,29841,158584,134429,2172,5360,5567,57110,1545,4597,284161,8612,9200,10413,59338,64850,57491,3638,133121,10400,25937,8821,56898,649,3248,5287,22876,113612,10891,129642,5125,5563,3636,241,1962,9871,1573,79993,1718,55301,6319,81544,3157,8435,6307,590,6720,9443,9896,79603,57552,55711,3156,23491,5046,3992,11001,84725,56895,5783,83401,7436,2194,2274,6604,10577,9261,57761,84879,340485,114879,79644,6713,5337,10715,1717,114880,9536,6296,9619 PLA2G4A,UGT8,MVK,ACSL1,ELOVL4,LPCAT2,PLEKHA5,LDLR,TNFAIP8L2,LPIN3,ABHD4,TIAM2,CDS1,CYP51A1,PLPP1,IDI1,GRHL1,FAAH2,STARD4,FABP6,PLTP,PRKACB,HRASLS,CYP1B1,MVD,GDPD1,PLPP2,HACD1,YAP1,PLEKHA1,ETNPPL,AHRR,INSIG1,ENPP6,PEMT,WWTR1,INPP4B,BDH2,BMP1,HPGD,PIK3C2B,INPP5F,CYP2U1,PPARGC1A,MBOAT2,PCSK5,PRKAA2,INPPL1,ALOX5AP,EHHADH,SEC24D,CYP2J2,ELOVL7,DHCR24,OLAH,SCD,GDPD5,HMGCS1,SOAT2,MSMO1,BCHE,SREBF1,MED7,FIG4,CERS4,NCEH1,FAR2,HMGCR,CES3,PCSK6,FADS1,SLC27A2,PLEKHA8,AGPAT4,PTPN13,ELOVL3,VLDLR,FASN,FHL2,SMARCD3,NPC2,MAPKAPK2,TRIB3,MFSD2A,ACER2,OSBPL5,SRD5A3,SQLE,PLD1,CERS1,DHCR7,OSBPL6,PTGES,ACSM3,ABCG1 R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.0151552468895128 -4.18940847764414 11 4 0.00411946446961895 971 10287 7082,1832,1829,100506658 TJP1,DSP,DSG2,OCLN R-HSA-167021 PLC-gamma1 signalling 0.016967983433111 -4.07642703808097 36 8 0.0082389289392379 971 10287 5153,5580,107,112,5577,3709,5578,5567 PDE1B,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PRKCA,PRKACB R-HSA-212718 EGFR interacts with phospholipase C-gamma 0.016967983433111 -4.07642703808097 36 8 0.0082389289392379 971 10287 5153,5580,107,112,5577,3709,5578,5567 PDE1B,PRKCD,ADCY1,ADCY6,PRKAR2B,ITPR2,PRKCA,PRKACB R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.0175111416966686 -4.04491793225894 17 5 0.00514933058702369 971 10287 8875,5167,79646,53354,2194 VNN2,ENPP1,PANK3,PANK1,FASN R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.0175111416966686 -4.04491793225894 17 5 0.00514933058702369 971 10287 8497,6616,10497,6812,8499 PPFIA4,SNAP25,UNC13B,STXBP1,PPFIA2 R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.0180519214494652 -4.01450314837489 330 43 0.0442842430484037 971 10287 10810,685,2335,9462,1850,1793,3709,5578,5580,3690,153090,4684,4233,2674,10125,5567,5159,4846,1843,2264,5058,54756,10451,5829,9047,9693,1852,22821,8822,10458,2260,9261,8660,57761,10718,3071,5579,5924,10000,2906,3082,5603,399473 WASF3,BTC,FN1,RASAL2,DUSP8,DOCK1,ITPR2,PRKCA,PRKCD,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PRKACB,PDGFRB,NOS3,DUSP1,FGFR4,PAK1,IL17RD,VAV3,PXN,SH2D2A,RAPGEF2,DUSP9,RASA3,FGF17,BAIAP2,FGFR1,MAPKAPK2,IRS2,TRIB3,NRG3,NCKAP1L,PRKCB,RASGRF2,AKT3,GRIN2D,HGF,MAPK13,SPRED3 R-HSA-112310 Neurotransmitter Release Cycle 0.0192014070286941 -3.95277171988896 51 10 0.0102986611740474 971 10287 10497,8499,4128,8825,8497,18,6616,6507,320,6812 UNC13B,PPFIA2,MAOA,LIN7A,PPFIA4,ABAT,SNAP25,SLC1A3,APBA1,STXBP1 R-HSA-5669034 TNFs bind their physiological receptors 0.0192421318474817 -3.9506530369991 30 7 0.00720906282183316 971 10287 9966,1896,608,60401,7292,7132,10673 TNFSF15,EDA,TNFRSF17,EDA2R,TNFSF4,TNFRSF1A,TNFSF13B R-HSA-445095 Interaction between L1 and Ankyrins 0.0192421318474817 -3.9506530369991 30 7 0.00720906282183316 971 10287 6331,6326,3786,6324,287,6334,6328 SCN5A,SCN2A,KCNQ3,SCN1B,ANK2,SCN8A,SCN3A R-HSA-1296072 Voltage gated Potassium channels 0.0197955375829836 -3.92229874127911 44 9 0.00926879505664264 971 10287 27012,7881,3786,27133,3755,3790,3752,3749,9312 KCNV1,KCNAB1,KCNQ3,KCNH5,KCNG1,KCNS3,KCND3,KCNC4,KCNB2 R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.0197955375829836 -3.92229874127911 44 9 0.00926879505664264 971 10287 85007,6520,123688,51166,10157,6999,8564,144193,8140 PHYKPL,SLC3A2,HYKK,AADAT,AASS,TDO2,KMO,AMDHD1,SLC7A5 R-HSA-5173105 O-linked glycosylation 0.0202142417191004 -3.90136788739679 114 18 0.0185375901132853 971 10287 145173,79875,11226,79695,6480,64409,114805,11174,256435,79623,170691,2591,2589,9508,80731,55901,374378,9331 B3GLCT,THSD4,GALNT6,GALNT12,ST6GAL1,GALNT17,GALNT13,ADAMTS6,ST6GALNAC3,GALNT14,ADAMTS17,GALNT3,GALNT1,ADAMTS3,THSD7B,THSD1,GALNT18,B4GALT6 R-HSA-71064 Lysine catabolism 0.0210644206292872 -3.86016988787969 12 4 0.00411946446961895 971 10287 85007,123688,51166,10157 PHYKPL,HYKK,AADAT,AASS R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.0212778527581869 -3.85008852382041 24 6 0.00617919670442842 971 10287 8497,6507,6616,10497,6812,8499 PPFIA4,SLC1A3,SNAP25,UNC13B,STXBP1,PPFIA2 R-HSA-6814848 Glycerophospholipid catabolism 0.0219513330597929 -3.81892740965161 7 3 0.00308959835221421 971 10287 81544,133121,284161 GDPD5,ENPP6,GDPD1 R-HSA-983712 Ion channel transport 0.0221987653348483 -3.80771860719788 209 29 0.0298661174047374 971 10287 54795,55129,285335,10079,2561,10396,55283,90423,94015,2566,6262,2570,23250,481,10110,444,57205,255231,540,41,23678,6446,7220,7222,150159,490,493,478,2040 TRPM4,ANO10,SLC9C1,ATP9A,GABRB2,ATP8A1,MCOLN3,ATP6V1E2,TTYH2,GABRG2,RYR2,GABRR2,ATP11A,ATP1B1,SGK2,ASPH,ATP10D,MCOLN2,ATP7B,ASIC1,SGK3,SGK1,TRPC1,TRPC3,SLC9B1,ATP2B1,ATP2B4,ATP1A3,STOM R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.0224067267297242 -3.79839406476818 18 5 0.00514933058702369 971 10287 8497,6616,10497,6812,8499 PPFIA4,SNAP25,UNC13B,STXBP1,PPFIA2 R-HSA-3000171 Non-integrin membrane-ECM interactions 0.0227405369820872 -3.78360617695055 45 9 0.00926879505664264 971 10287 3655,3690,3912,3673,10319,9672,5578,9378,780 ITGA6,ITGB3,LAMB1,ITGA2,LAMC3,SDC3,PRKCA,NRXN1,DDR1 R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.0227405369820872 -3.78360617695055 45 9 0.00926879505664264 971 10287 5366,27166,665,604,27113,55240,8794,64065,3486 PMAIP1,PRELID1,BNIP3L,BCL6,BBC3,STEAP3,TNFRSF10C,PERP,IGFBP3 R-HSA-70614 Amino acid synthesis and interconversion (transamination) 0.022890282571107 -3.77704280035349 31 7 0.00720906282183316 971 10287 84706,256987,440,26227,5723,347735,5831 GPT2,SERINC5,ASNS,PHGDH,PSPH,SERINC2,PYCR1 R-HSA-75153 Apoptotic execution phase 0.0247100453786529 -3.70054542253438 53 10 0.0102986611740474 971 10287 2934,1829,5580,5588,7082,7431,6304,1832,8428,100506658 GSN,DSG2,PRKCD,PRKCQ,TJP1,VIM,SATB1,DSP,STK24,OCLN R-HSA-8875791 MET activates STAT3 0.0250267608326273 -3.68780959331406 3 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-380615 Serotonin clearance from the synaptic cleft 0.0250267608326273 -3.68780959331406 3 2 0.00205973223480947 971 10287 4128,217 MAOA,ALDH2 R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E) 0.0250267608326273 -3.68780959331406 3 2 0.00205973223480947 971 10287 9899,6616 SV2B,SNAP25 R-HSA-70263 Gluconeogenesis 0.0269887892485595 -3.61233371221892 32 7 0.00720906282183316 971 10287 2597,5106,2026,2023,230,226,5567 GAPDH,PCK2,ENO2,ENO1,ALDOC,ALDOA,PRKACB R-HSA-186797 Signaling by PDGF 0.0273277012471134 -3.59985439355249 376 47 0.0484037075180227 971 10287 1299,685,5153,2335,9462,1850,1287,1147,6777,3709,5578,118788,5580,3690,112,153090,4684,4233,1298,2674,10125,5567,5159,1843,2264,54756,1292,1285,3164,9693,1286,107,1852,22821,192670,5577,8822,2260,8660,57761,10718,5924,10000,7060,2906,3082,399473 COL9A3,BTC,PDE1B,FN1,RASAL2,DUSP8,COL4A5,CHUK,STAT5B,ITPR2,PRKCA,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,COL9A2,GFRA1,RASGRP1,PRKACB,PDGFRB,DUSP1,FGFR4,IL17RD,COL6A2,COL4A3,NR4A1,RAPGEF2,COL4A4,ADCY1,DUSP9,RASA3,AGO4,PRKAR2B,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,THBS4,GRIN2D,HGF,SPRED3 R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.0278535606320368 -3.58079447043857 54 10 0.0102986611740474 971 10287 10855,64131,222537,9672,9953,63827,10082,11285,26035,266722 HPSE,XYLT1,HS3ST5,SDC3,HS3ST3B1,BCAN,GPC6,B4GALT7,GLCE,HS6ST3 R-HSA-1502540 Signaling by Activin 0.0282018206833061 -3.56836873988438 13 4 0.00411946446961895 971 10287 4088,92,93,130399 SMAD3,ACVR2A,ACVR2B,ACVR1C R-HSA-112308 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 0.0282018206833061 -3.56836873988438 13 4 0.00411946446961895 971 10287 785,777,783,781 CACNB4,CACNA1E,CACNB2,CACNA2D1 R-HSA-1442490 Collagen degradation 0.0308901517997083 -3.47731785786144 40 8 0.0082389289392379 971 10287 4324,1299,84570,80781,1310,85007,7373,1298 MMP15,COL9A3,COL25A1,COL18A1,COL19A1,PHYKPL,COL14A1,COL9A2 R-HSA-1483255 PI Metabolism 0.0328098646111724 -3.41702605846774 79 13 0.0133882595262616 971 10287 3636,84725,133121,5783,54477,284161,79626,8821,22876,5287,59338,9896,81544 INPPL1,PLEKHA8,ENPP6,PTPN13,PLEKHA5,GDPD1,TNFAIP8L2,INPP4B,INPP5F,PIK3C2B,PLEKHA1,FIG4,GDPD5 R-HSA-2672351 Stimuli-sensing channels 0.0340916618890389 -3.37870244397543 104 16 0.0164778578784758 971 10287 255231,54795,55129,285335,41,55283,23678,94015,6262,6446,7220,10110,444,7222,150159,2040 MCOLN2,TRPM4,ANO10,SLC9C1,ASIC1,MCOLN3,SGK3,TTYH2,RYR2,SGK1,TRPC1,SGK2,ASPH,TRPC3,SLC9B1,STOM R-HSA-8874081 MET activates PTK2 signaling 0.0346522450698815 -3.36239276266361 20 5 0.00514933058702369 971 10287 10319,3082,4233,3912,3673 LAMC3,HGF,MET,LAMB1,ITGA2 R-HSA-3000170 Syndecan interactions 0.0346522450698815 -3.36239276266361 20 5 0.00514933058702369 971 10287 9672,5578,3655,3690,3673 SDC3,PRKCA,ITGA6,ITGB3,ITGA2 R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 0.0367547843046401 -3.30348687663637 27 6 0.00617919670442842 971 10287 22821,153090,5829,399473,9462,1793 RASA3,DAB2IP,PXN,SPRED3,RASAL2,DOCK1 R-HSA-913709 O-linked glycosylation of mucins 0.0395492207972027 -3.23020928667677 65 11 0.0113285272914521 971 10287 2591,2589,11226,79695,6480,64409,114805,256435,79623,374378,9331 GALNT3,GALNT1,GALNT6,GALNT12,ST6GAL1,GALNT17,GALNT13,ST6GALNAC3,GALNT14,GALNT18,B4GALT6 R-HSA-1181150 Signaling by NODAL 0.0420618123753544 -3.16861501939927 21 5 0.00514933058702369 971 10287 4088,92,93,130399,5046 SMAD3,ACVR2A,ACVR2B,ACVR1C,PCSK6 R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.0420618123753544 -3.16861501939927 21 5 0.00514933058702369 971 10287 27113,55240,5366,27166,665 BBC3,STEAP3,PMAIP1,PRELID1,BNIP3L R-HSA-445144 Signal transduction by L1 0.0420618123753544 -3.16861501939927 21 5 0.00514933058702369 971 10287 5058,4684,8829,2260,3690 PAK1,NCAM1,NRP1,FGFR1,ITGB3 R-HSA-174824 Lipoprotein metabolism 0.0433700437646991 -3.13798631203463 74 12 0.0123583934088568 971 10287 8435,7436,3949,649,10577,57552,5360,5567,9619,5125,23491,5046 SOAT2,VLDLR,LDLR,BMP1,NPC2,NCEH1,PLTP,PRKACB,ABCG1,PCSK5,CES3,PCSK6 R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation 0.045667333590737 -3.08637203775204 9 3 0.00308959835221421 971 10287 4040,8322,8325 LRP6,FZD4,FZD8 R-HSA-2243919 Crosslinking of collagen fibrils 0.045667333590737 -3.08637203775204 9 3 0.00308959835221421 971 10287 84171,649,7093 LOXL4,BMP1,TLL2 R-HSA-1296052 Ca2+ activated K+ channels 0.045667333590737 -3.08637203775204 9 3 0.00308959835221421 971 10287 27345,3781,27094 KCNMB4,KCNN2,KCNMB3 R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.0462978159711168 -3.07266049025272 15 4 0.00411946446961895 971 10287 8829,10371,2242,5362 NRP1,SEMA3A,FES,PLXNA2 R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A) 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 9899,6616 SV2B,SNAP25 R-HSA-69560 Transcriptional activation of p53 responsive genes 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 57060,25946 PCBP4,ZNF385A R-HSA-428542 Regulation of Commissural axon pathfinding by Slit and Robo 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 6092,9353 ROBO2,SLIT2 R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 57060,25946 PCBP4,ZNF385A R-HSA-6807062 Cholesterol biosynthesis via lathosterol 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 1717,1718 DHCR7,DHCR24 R-HSA-6807047 Cholesterol biosynthesis via desmosterol 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 1717,1718 DHCR7,DHCR24 R-HSA-167060 NGF processing 0.0469357799431741 -3.05897499581396 4 2 0.00205973223480947 971 10287 5046,5125 PCSK6,PCSK5 R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.0471692262862805 -3.05401358448573 51 9 0.00926879505664264 971 10287 10090,337876,64131,9672,92126,22856,63827,11285,10082 UST,CHSY3,XYLT1,SDC3,DSEL,CHSY1,BCAN,B4GALT7,GPC6 R-HSA-192823 Viral mRNA Translation 0.0491556032354447 -3.01276443613104 92 14 0.0144181256436663 971 10287 6224,6154,6136,6158,6205,5611,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,DNAJC3,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-156902 Peptide chain elongation 0.0491556032354447 -3.01276443613104 92 14 0.0144181256436663 971 10287 6224,6154,6136,1938,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,EEF2,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-166520 Signalling by NGF 0.0496566612186241 -3.00262273397297 477 56 0.0576725025746653 971 10287 685,26052,5153,2335,9462,1850,9826,1147,3709,5578,26230,55160,6196,118788,23263,5580,3690,112,153090,4684,4233,2674,10125,5567,5159,5046,1843,2264,54756,10451,3164,9693,57580,107,1852,22821,84033,192670,5577,8822,2260,26084,9261,8660,57761,10718,6456,27018,10000,5924,2906,5603,3082,399473,4208,5125 BTC,DNM3,PDE1B,FN1,RASAL2,DUSP8,ARHGEF11,CHUK,ITPR2,PRKCA,TIAM2,ARHGEF10L,RPS6KA2,PIK3AP1,MCF2L,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PRKACB,PDGFRB,PCSK6,DUSP1,FGFR4,IL17RD,VAV3,NR4A1,RAPGEF2,PREX1,ADCY1,DUSP9,RASA3,OBSCN,AGO4,PRKAR2B,FGF17,FGFR1,ARHGEF26,MAPKAPK2,IRS2,TRIB3,NRG3,SH3GL2,BEX3,AKT3,RASGRF2,GRIN2D,MAPK13,HGF,SPRED3,MEF2C,PCSK5 R-HSA-375170 CDO in myogenesis 0.0502631324435405 -2.99048342402686 29 6 0.00617919670442842 971 10287 100271849,1000,5608,1496,4756,4208 MEF2B,CDH2,MAP2K6,CTNNA2,NEO1,MEF2C R-HSA-525793 Myogenesis 0.0502631324435405 -2.99048342402686 29 6 0.00617919670442842 971 10287 100271849,1000,5608,1496,4756,4208 MEF2B,CDH2,MAP2K6,CTNNA2,NEO1,MEF2C R-HSA-1483257 Phospholipid metabolism 0.0520662919732339 -2.95523752668732 207 27 0.0278063851699279 971 10287 5321,3636,84725,54947,5783,54477,56895,284161,79626,59338,64900,63874,81544,64850,1040,590,133121,84879,10400,114879,8821,22876,5287,5337,9896,129642,57110 PLA2G4A,INPPL1,PLEKHA8,LPCAT2,PTPN13,PLEKHA5,AGPAT4,GDPD1,TNFAIP8L2,PLEKHA1,LPIN3,ABHD4,GDPD5,ETNPPL,CDS1,BCHE,ENPP6,MFSD2A,PEMT,OSBPL5,INPP4B,INPP5F,PIK3C2B,PLD1,FIG4,MBOAT2,HRASLS R-HSA-76002 Platelet activation, signaling and aggregation 0.0558530558253348 -2.8850310400965 282 35 0.0360453141091658 971 10287 5321,55970,2335,3709,2621,5028,3937,5578,6414,57406,5099,5580,3690,5627,5874,6850,10125,9846,7424,10451,5768,10257,5777,11069,9749,5588,5919,2770,747,5579,59345,10000,226,3082,7222 PLA2G4A,GNG12,FN1,ITPR2,GAS6,P2RY1,LCP2,PRKCA,SELENOP,ABHD6,PCDH7,PRKCD,ITGB3,PROS1,RAB27B,SYK,RASGRP1,GAB2,VEGFC,VAV3,QSOX1,ABCC4,PTPN6,RAPGEF4,PHACTR2,PRKCQ,RARRES2,GNAI1,DAGLA,PRKCB,GNB4,AKT3,ALDOA,HGF,TRPC3 R-HSA-1474228 Degradation of the extracellular matrix 0.0567899163602959 -2.86839649788318 111 16 0.0164778578784758 971 10287 4324,1299,84570,1515,3912,726,649,80781,1310,85007,63827,7373,1298,4325,50859,7093 MMP15,COL9A3,COL25A1,CTSV,LAMB1,CAPN5,BMP1,COL18A1,COL19A1,PHYKPL,BCAN,COL14A1,COL9A2,MMP16,SPOCK3,TLL2 R-HSA-392517 Rap1 signalling 0.0572708325401447 -2.85996381557457 16 4 0.00411946446961895 971 10287 10125,5567,11069,5592 RASGRP1,PRKACB,RAPGEF4,PRKG1 R-HSA-163615 PKA activation 0.0572708325401447 -2.85996381557457 16 4 0.00411946446961895 971 10287 112,5577,5567,107 ADCY6,PRKAR2B,PRKACB,ADCY1 R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.0591524820678869 -2.82763672717462 86 13 0.0133882595262616 971 10287 5058,10810,10451,2268,3071,1793,4651,644150,5580,5337,3709,6850,10458 PAK1,WASF3,VAV3,FGR,NCKAP1L,DOCK1,MYO10,WIPF3,PRKCD,PLD1,ITPR2,SYK,BAIAP2 R-HSA-418886 Netrin mediated repulsion signals 0.0607770871196841 -2.80054241762245 10 3 0.00308959835221421 971 10287 8633,219699,1630 UNC5C,UNC5B,DCC R-HSA-112311 Neurotransmitter Clearance In The Synaptic Cleft 0.0607770871196841 -2.80054241762245 10 3 0.00308959835221421 971 10287 4128,217,590 MAOA,ALDH2,BCHE R-HSA-2046105 Linoleic acid (LA) metabolism 0.0607770871196841 -2.80054241762245 10 3 0.00308959835221421 971 10287 3992,2180,83401 FADS1,ACSL1,ELOVL3 R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.0607770871196841 -2.80054241762245 10 3 0.00308959835221421 971 10287 79047,284252,7020 KCTD15,KCTD1,TFAP2A R-HSA-418890 Role of second messengers in netrin-1 signaling 0.0607770871196841 -2.80054241762245 10 3 0.00308959835221421 971 10287 7220,7222,1630 TRPC1,TRPC3,DCC R-HSA-156842 Eukaryotic Translation Elongation 0.0660709539437095 -2.71702605466544 96 14 0.0144181256436663 971 10287 6224,6154,6136,1938,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,EEF2,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-8875878 MET promotes cell motility 0.066449126597462 -2.71131863766454 31 6 0.00617919670442842 971 10287 10319,3082,85440,4233,3912,3673 LAMC3,HGF,DOCK7,MET,LAMB1,ITGA2 R-HSA-2022928 HS-GAG biosynthesis 0.066449126597462 -2.71131863766454 31 6 0.00617919670442842 971 10287 9672,9953,10082,222537,266722,26035 SDC3,HS3ST3B1,GPC6,HS3ST5,HS6ST3,GLCE R-HSA-111931 PKA-mediated phosphorylation of CREB 0.0695045835706099 -2.66636257792978 17 4 0.00411946446961895 971 10287 112,5577,5567,107 ADCY6,PRKAR2B,PRKACB,ADCY1 R-HSA-164378 PKA activation in glucagon signalling 0.0695045835706099 -2.66636257792978 17 4 0.00411946446961895 971 10287 112,5577,5567,107 ADCY6,PRKAR2B,PRKACB,ADCY1 R-HSA-171052 LDL-mediated lipid transport 0.0696016162353815 -2.66496749013866 24 5 0.00514933058702369 971 10287 10577,57552,8435,3949,23491 NPC2,NCEH1,SOAT2,LDLR,CES3 R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 0.069745974947084 -2.66289556679761 39 7 0.00720906282183316 971 10287 170691,11174,145173,9508,55901,79875,80731 ADAMTS17,ADAMTS6,B3GLCT,ADAMTS3,THSD1,THSD4,THSD7B R-HSA-74713 IRS activation 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 8660,2887 IRS2,GRB10 R-HSA-114516 Disinhibition of SNARE formation 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 5578,5579 PRKCA,PRKCB R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 4869,7020 NPM1,TFAP2A R-HSA-196819 Vitamin B1 (thiamin) metabolism 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 10560,27010 SLC19A2,TPK1 R-HSA-8875513 MET interacts with TNS proteins 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-426048 Arachidonate production from DAG 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 747,57406 DAGLA,ABHD6 R-HSA-8865999 MET activates PTPN11 0.0733950627706253 -2.61189861032942 5 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-399719 Trafficking of AMPA receptors 0.0755553582948045 -2.58288966895567 32 6 0.00617919670442842 971 10287 23426,10368,4646,5578,5579,9495 GRIP1,CACNG3,MYO6,PRKCA,PRKCB,AKAP5 R-HSA-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 0.0755553582948045 -2.58288966895567 32 6 0.00617919670442842 971 10287 23426,10368,4646,5578,5579,9495 GRIP1,CACNG3,MYO6,PRKCA,PRKCB,AKAP5 R-HSA-2424491 DAP12 signaling 0.0757423682362394 -2.58041758902479 356 42 0.043254376930999 971 10287 685,5153,2335,9462,1850,1147,3709,3937,5578,118788,5580,3690,112,153090,4684,4233,6850,2674,10125,5567,5159,1843,2264,54756,10451,3164,9693,107,1852,22821,5577,192670,8822,2260,8660,57761,10718,5924,10000,2906,3082,399473 BTC,PDE1B,FN1,RASAL2,DUSP8,CHUK,ITPR2,LCP2,PRKCA,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,SYK,GFRA1,RASGRP1,PRKACB,PDGFRB,DUSP1,FGFR4,IL17RD,VAV3,NR4A1,RAPGEF2,ADCY1,DUSP9,RASA3,PRKAR2B,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,GRIN2D,HGF,SPRED3 R-HSA-70326 Glucose metabolism 0.0768803580152381 -2.56550485752504 81 12 0.0123583934088568 971 10287 5210,2597,2026,5208,230,226,3099,3098,5106,178,2023,5567 PFKFB4,GAPDH,ENO2,PFKFB2,ALDOC,ALDOA,HK2,HK1,PCK2,AGL,ENO1,PRKACB R-HSA-2022923 Dermatan sulfate biosynthesis 0.0778852772066641 -2.5525183400308 11 3 0.00308959835221421 971 10287 10090,92126,63827 UST,DSEL,BCAN R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.0778852772066641 -2.5525183400308 11 3 0.00308959835221421 971 10287 468,7494,1649 ATF4,XBP1,DDIT3 R-HSA-376172 DSCAM interactions 0.0778852772066641 -2.5525183400308 11 3 0.00308959835221421 971 10287 5058,5603,1630 PAK1,MAPK13,DCC R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.0778852772066641 -2.5525183400308 11 3 0.00308959835221421 971 10287 51477,3628,8821 ISYNA1,INPP1,INPP4B R-HSA-8875555 MET activates RAP1 and RAC1 0.0778852772066641 -2.5525183400308 11 3 0.00308959835221421 971 10287 3082,85440,4233 HGF,DOCK7,MET R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.0779881192514858 -2.55119878118265 40 7 0.00720906282183316 971 10287 4869,79047,10765,7039,4609,284252,7020 NPM1,KCTD15,KDM5B,TGFA,MYC,KCTD1,TFAP2A R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.0792689829344234 -2.53490836261246 90 13 0.0133882595262616 971 10287 2264,8660,685,10718,118788,3164,10000,1147,3082,8822,4233,5159,2260 FGFR4,IRS2,BTC,NRG3,PIK3AP1,NR4A1,AKT3,CHUK,HGF,FGF17,MET,PDGFRB,FGFR1 R-HSA-3000157 Laminin interactions 0.080545444284795 -2.51893372856511 25 5 0.00514933058702369 971 10287 10319,80781,3655,3912,3673 LAMC3,COL18A1,ITGA6,LAMB1,ITGA2 R-HSA-3295583 TRP channels 0.080545444284795 -2.51893372856511 25 5 0.00514933058702369 971 10287 255231,7220,54795,7222,55283 MCOLN2,TRPC1,TRPM4,TRPC3,MCOLN3 R-HSA-187037 NGF signalling via TRKA from the plasma membrane 0.0817470588976464 -2.50412544663915 387 45 0.0463439752832132 971 10287 685,26052,5153,2335,9462,1850,1147,3709,5578,6196,118788,5580,3690,112,153090,4684,4233,2674,10125,5567,5159,1843,2264,54756,3164,9693,107,1852,22821,192670,5577,8822,2260,8660,9261,57761,10718,6456,5924,10000,2906,3082,5603,399473,4208 BTC,DNM3,PDE1B,FN1,RASAL2,DUSP8,CHUK,ITPR2,PRKCA,RPS6KA2,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PRKACB,PDGFRB,DUSP1,FGFR4,IL17RD,NR4A1,RAPGEF2,ADCY1,DUSP9,RASA3,AGO4,PRKAR2B,FGF17,FGFR1,IRS2,MAPKAPK2,TRIB3,NRG3,SH3GL2,RASGRF2,AKT3,GRIN2D,HGF,MAPK13,SPRED3,MEF2C R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.0824408982043795 -2.4956736277696 65 10 0.0102986611740474 971 10287 2264,8660,685,10718,118788,3082,8822,4233,5159,2260 FGFR4,IRS2,BTC,NRG3,PIK3AP1,HGF,FGF17,MET,PDGFRB,FGFR1 R-HSA-3000178 ECM proteoglycans 0.0847103521508312 -2.4685174634132 57 9 0.00926879505664264 971 10287 1299,4038,3690,3912,3673,5802,63827,4684,1298 COL9A3,LRP4,ITGB3,LAMB1,ITGA2,PTPRS,BCAN,NCAM1,COL9A2 R-HSA-163359 Glucagon signaling in metabolic regulation 0.0853323435383591 -2.46120172239781 33 6 0.00617919670442842 971 10287 112,5577,55970,59345,5567,107 ADCY6,PRKAR2B,GNG12,GNB4,PRKACB,ADCY1 R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.0863051077742499 -2.44986649638405 49 8 0.0082389289392379 971 10287 5325,10769,57060,8900,4869,85456,25946,2810 PLAGL1,PLK2,PCBP4,CCNA1,NPM1,TNKS1BP1,ZNF385A,SFN R-HSA-1296071 Potassium Channels 0.0864722666390063 -2.44793153334299 100 14 0.0144181256436663 971 10287 27012,55970,3761,27345,3781,7881,3786,27133,3755,3790,27094,3752,3749,9312 KCNV1,GNG12,KCNJ4,KCNMB4,KCNN2,KCNAB1,KCNQ3,KCNH5,KCNG1,KCNS3,KCNMB3,KCND3,KCNC4,KCNB2 R-HSA-202733 Cell surface interactions at the vascular wall 0.0886347643287783 -2.42323112441564 136 18 0.0185375901132853 971 10287 6520,2335,2888,5777,3655,3512,6402,9672,481,2621,83700,4072,23657,2995,3690,8140,5627,58494 SLC3A2,FN1,GRB14,PTPN6,ITGA6,JCHAIN,SELL,SDC3,ATP1B1,GAS6,JAM3,EPCAM,SLC7A11,GYPC,ITGB3,SLC7A5,PROS1,JAM2 R-HSA-375165 NCAM signaling for neurite out-growth 0.092185152820219 -2.38395619370535 276 33 0.0339855818743563 971 10287 1299,685,2335,9462,1850,1287,785,783,3690,153090,4684,4233,1298,2674,10125,5159,1843,2264,54756,1292,1285,9693,1286,1852,22821,8822,2260,8660,10718,5924,3082,2906,399473 COL9A3,BTC,FN1,RASAL2,DUSP8,COL4A5,CACNB4,CACNB2,ITGB3,DAB2IP,NCAM1,MET,COL9A2,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,COL6A2,COL4A3,RAPGEF2,COL4A4,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,HGF,GRIN2D,SPRED3 R-HSA-936837 Ion transport by P-type ATPases 0.0923212911675765 -2.38248049053617 58 9 0.00926879505664264 971 10287 10079,540,10396,23250,481,57205,490,493,478 ATP9A,ATP7B,ATP8A1,ATP11A,ATP1B1,ATP10D,ATP2B1,ATP2B4,ATP1A3 R-HSA-379716 Cytosolic tRNA aminoacylation 0.0923474026803991 -2.3821976974709 26 5 0.00514933058702369 971 10287 833,4141,2617,16,7453 CARS,MARS,GARS,AARS,WARS R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 0.0923474026803991 -2.3821976974709 26 5 0.00514933058702369 971 10287 9672,63827,10082,64131,11285 SDC3,BCAN,GPC6,XYLT1,B4GALT7 R-HSA-210991 Basigin interactions 0.0923474026803991 -2.3821976974709 26 5 0.00514933058702369 971 10287 6520,481,23657,3655,8140 SLC3A2,ATP1B1,SLC7A11,ITGA6,SLC7A5 R-HSA-418555 G alpha (s) signalling events 0.0931960654131834 -2.37304977477848 146 19 0.01956745623069 971 10287 11245,55970,5153,79924,107,10203,5151,2870,157,2770,285601,3363,2838,59345,10846,153,112,5144,7253 GPR176,GNG12,PDE1B,ADM2,ADCY1,CALCRL,PDE8A,GRK6,GRK3,GNAI1,GPR150,HTR7,GPR15,GNB4,PDE10A,ADRB1,ADCY6,PDE4D,TSHR R-HSA-5602410 TLR3 deficiency - HSE 0.0943909789051214 -2.36030977284281 1 1 0.00102986611740474 971 10287 7098 TLR3 R-HSA-1839128 FGFR4 mutant receptor activation 0.0943909789051214 -2.36030977284281 1 1 0.00102986611740474 971 10287 2264 FGFR4 R-HSA-5657655 MGMT-mediated DNA damage reversal 0.0943909789051214 -2.36030977284281 1 1 0.00102986611740474 971 10287 4255 MGMT R-HSA-1839120 Signaling by FGFR1 amplification mutants 0.0943909789051214 -2.36030977284281 1 1 0.00102986611740474 971 10287 2260 FGFR1 R-HSA-5602415 UNC93B1 deficiency - HSE 0.0943909789051214 -2.36030977284281 1 1 0.00102986611740474 971 10287 7098 TLR3 R-HSA-8848021 Signaling by PTK6 0.0966594282072731 -2.33656152808784 67 10 0.0102986611740474 971 10287 685,10718,5829,9462,1793,120892,22821,153090,399473,202559 BTC,NRG3,PXN,RASAL2,DOCK1,LRRK2,RASA3,DAB2IP,SPRED3,KHDRBS2 R-HSA-879518 Transport of organic anions 0.0968255627338935 -2.33484424173254 12 3 0.00308959835221421 971 10287 353189,28232,6567 SLCO4C1,SLCO3A1,SLC16A2 R-HSA-1433617 Regulation of signaling by NODAL 0.0968255627338935 -2.33484424173254 12 3 0.00308959835221421 971 10287 92,93,130399 ACVR2A,ACVR2B,ACVR1C R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.0974000680370183 -2.32892836980188 156 20 0.0205973223480947 971 10287 3048,1793,3798,2625,5577,3046,23414,23046,1795,80005,1794,85440,2624,30845,55605,57572,23095,81704,5567,23348 HBG2,DOCK1,KIF5A,GATA3,PRKAR2B,HBE1,ZFPM2,KIF21B,DOCK3,DOCK5,DOCK2,DOCK7,GATA2,EHD3,KIF21A,DOCK6,KIF1B,DOCK8,PRKACB,DOCK9 R-HSA-3928664 Ephrin signaling 0.0975883588450631 -2.32699706680527 19 4 0.00411946446961895 971 10287 1948,5058,2051,2047 EFNB2,PAK1,EPHB6,EPHB1 R-HSA-177929 Signaling by EGFR 0.0985584242593008 -2.31710576695358 364 42 0.043254376930999 971 10287 685,5153,2335,9462,1850,1147,3709,5578,118788,5580,3690,112,153090,4684,4233,10253,2674,10125,5567,5159,1843,2264,54756,5829,3164,9693,107,1852,22821,5577,192670,8822,2260,8660,57761,10718,6456,5924,10000,2906,3082,399473 BTC,PDE1B,FN1,RASAL2,DUSP8,CHUK,ITPR2,PRKCA,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,SPRY2,GFRA1,RASGRP1,PRKACB,PDGFRB,DUSP1,FGFR4,IL17RD,PXN,NR4A1,RAPGEF2,ADCY1,DUSP9,RASA3,PRKAR2B,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,SH3GL2,RASGRF2,AKT3,GRIN2D,HGF,SPRED3 R-HSA-2142753 Arachidonic acid metabolism 0.100319674522382 -2.29939344649691 59 9 0.00926879505664264 971 10287 9261,5321,3248,113612,241,1573,158584,9536,1545 MAPKAPK2,PLA2G4A,HPGD,CYP2U1,ALOX5AP,CYP2J2,FAAH2,PTGES,CYP1B1 R-HSA-8851907 MET activates PI3K/AKT signaling 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-2142700 Synthesis of Lipoxins (LX) 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 3248,241 HPGD,ALOX5AP R-HSA-5626978 TNFR1-mediated ceramide production 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 10399,7132 RACK1,TNFRSF1A R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-6806942 MET Receptor Activation 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-446199 Synthesis of Dolichyl-phosphate 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 4597,79644 MVD,SRD5A3 R-HSA-5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 0.103352184558674 -2.26961285559663 6 2 0.00205973223480947 971 10287 83999,22943 KREMEN1,DKK1 R-HSA-373755 Semaphorin interactions 0.104277651316092 -2.26069821303112 68 10 0.0102986611740474 971 10287 5788,5058,56896,9826,5362,4233,8829,10371,57556,2242 PTPRC,PAK1,DPYSL5,ARHGEF11,PLXNA2,MET,NRP1,SEMA3A,SEMA6A,FES R-HSA-2408522 Selenoamino acid metabolism 0.104539010959379 -2.25819496662427 121 16 0.0164778578784758 971 10287 6224,6154,6136,6158,6205,6144,875,4141,6206,6124,51121,6228,23521,1491,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,CBS,MARS,RPS12,RPL4,RPL26L1,RPS23,RPL13A,CTH,RPS13,RPL34 R-HSA-1433557 Signaling by SCF-KIT 0.104715391980967 -2.25650916158618 337 39 0.0401647785787848 971 10287 685,2335,9462,1850,1147,6777,5578,118788,3690,153090,4684,4233,2674,10125,5159,2242,9846,1843,2264,54756,2241,10076,3164,5777,9693,1852,22821,192670,8822,2260,8660,57761,10718,5924,10000,2906,3082,2887,399473 BTC,FN1,RASAL2,DUSP8,CHUK,STAT5B,PRKCA,PIK3AP1,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,FES,GAB2,DUSP1,FGFR4,IL17RD,FER,PTPRU,NR4A1,PTPN6,RAPGEF2,DUSP9,RASA3,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,GRIN2D,HGF,GRB10,SPRED3 R-HSA-977606 Regulation of Complement cascade 0.104982088676497 -2.25396552740908 27 5 0.00514933058702369 971 10287 1604,5627,3075,720,725 CD55,PROS1,CFH,C4A,C4BPB R-HSA-380994 ATF4 activates genes 0.104982088676497 -2.25396552740908 27 5 0.00514933058702369 971 10287 467,440,468,9709,1649 ATF3,ASNS,ATF4,HERPUD1,DDIT3 R-HSA-4791275 Signaling by WNT in cancer 0.10685715819931 -2.23626230648655 35 6 0.00617919670442842 971 10287 4040,1488,8322,83999,8325,22943 LRP6,CTBP2,FZD4,KREMEN1,FZD8,DKK1 R-HSA-193648 NRAGE signals death through JNK 0.108702407410288 -2.21914133781146 60 9 0.00926879505664264 971 10287 55160,10451,9826,5924,23263,57580,84033,26230,26084 ARHGEF10L,VAV3,ARHGEF11,RASGRF2,MCF2L,PREX1,OBSCN,TIAM2,ARHGEF26 R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.109871930517375 -2.20843985950013 131 17 0.0175077239958805 971 10287 2264,685,3164,192670,1147,8822,2260,8660,57761,10718,118788,10000,3082,4233,6850,5159,9846 FGFR4,BTC,NR4A1,AGO4,CHUK,FGF17,FGFR1,IRS2,TRIB3,NRG3,PIK3AP1,AKT3,HGF,MET,SYK,PDGFRB,GAB2 R-HSA-2408557 Selenocysteine synthesis 0.109917233387247 -2.20802762015484 95 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.110366267590364 -2.20395073901693 122 16 0.0164778578784758 971 10287 8875,55034,349565,160428,53354,2194,9446,83594,10560,27010,23475,5167,119391,10840,79646,83666 VNN2,MOCOS,NMNAT3,ALDH1L2,PANK1,FASN,GSTO1,NUDT12,SLC19A2,TPK1,QPRT,ENPP1,GSTO2,ALDH1L1,PANK3,PARP9 R-HSA-194223 HDL-mediated lipid transport 0.113322387291301 -2.17751853742826 20 4 0.00411946446961895 971 10287 5360,5567,9619,649 PLTP,PRKACB,ABCG1,BMP1 R-HSA-72764 Eukaryotic Translation Termination 0.116784722935769 -2.14742301392546 96 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-74217 Purine salvage 0.117412685346285 -2.14206032507201 13 3 0.00308959835221421 971 10287 161823,4860,270 ADAL,PNP,AMPD1 R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.117412685346285 -2.14206032507201 13 3 0.00308959835221421 971 10287 57060,8900,25946 PCBP4,CCNA1,ZNF385A R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.117412685346285 -2.14206032507201 13 3 0.00308959835221421 971 10287 468,7494,1649 ATF4,XBP1,DDIT3 R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.117464961308886 -2.14161519149537 61 9 0.00926879505664264 971 10287 5058,10810,10451,3071,1793,4651,644150,6850,10458 PAK1,WASF3,VAV3,NCKAP1L,DOCK1,MYO10,WIPF3,SYK,BAIAP2 R-HSA-354192 Integrin alphaIIb beta3 signaling 0.118417646070224 -2.13353752988198 28 5 0.00514933058702369 971 10287 2335,6850,10125,3690,11069 FN1,SYK,RASGRP1,ITGB3,RAPGEF4 R-HSA-264876 Insulin processing 0.118417646070224 -2.13353752988198 28 5 0.00514933058702369 971 10287 3800,56605,25924,1363,3798 KIF5C,ERO1B,MYRIP,CPE,KIF5A R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.118417646070224 -2.13353752988198 28 5 0.00514933058702369 971 10287 112,55970,783,59345,2770 ADCY6,GNG12,CACNB2,GNB4,GNAI1 R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 0.118417646070224 -2.13353752988198 28 5 0.00514933058702369 971 10287 2180,6785,79993,83401,9200 ACSL1,ELOVL4,ELOVL7,ELOVL3,HACD1 R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.118573777639392 -2.13221991602649 36 6 0.00617919670442842 971 10287 6446,639,9099,900,10000,8900 SGK1,PRDM1,USP2,CCNG1,AKT3,CCNA1 R-HSA-2172127 DAP12 interactions 0.121973536989831 -2.10395116769666 371 42 0.043254376930999 971 10287 685,5153,2335,9462,1850,1147,3709,3937,5578,118788,5580,3690,112,153090,4684,4233,6850,2674,10125,5567,5159,1843,2264,54756,10451,3164,9693,107,1852,22821,5577,192670,8822,2260,8660,57761,10718,5924,10000,2906,3082,399473 BTC,PDE1B,FN1,RASAL2,DUSP8,CHUK,ITPR2,LCP2,PRKCA,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,SYK,GFRA1,RASGRP1,PRKACB,PDGFRB,DUSP1,FGFR4,IL17RD,VAV3,NR4A1,RAPGEF2,ADCY1,DUSP9,RASA3,PRKAR2B,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,GRIN2D,HGF,SPRED3 R-HSA-186763 Downstream signal transduction 0.123602154625619 -2.09068730186438 352 40 0.0411946446961895 971 10287 685,5153,2335,9462,1850,1147,6777,3709,5578,118788,5580,3690,112,153090,4684,4233,2674,10125,5159,5567,1843,2264,54756,3164,9693,107,1852,22821,5577,192670,8822,2260,8660,57761,10718,5924,10000,2906,3082,399473 BTC,PDE1B,FN1,RASAL2,DUSP8,CHUK,STAT5B,ITPR2,PRKCA,PIK3AP1,PRKCD,ITGB3,ADCY6,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,PRKACB,DUSP1,FGFR4,IL17RD,NR4A1,RAPGEF2,ADCY1,DUSP9,RASA3,PRKAR2B,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,GRIN2D,HGF,SPRED3 R-HSA-166658 Complement cascade 0.127199955210992 -2.06199498019102 45 7 0.00720906282183316 971 10287 715,1604,5627,10584,3075,720,725 C1R,CD55,PROS1,COLEC10,CFH,C4A,C4BPB R-HSA-6807004 Negative regulation of MET activity 0.130089581387426 -2.03953197824282 21 4 0.00411946446961895 971 10287 3082,5795,4233,6456 HGF,PTPRJ,MET,SH3GL2 R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.130089581387426 -2.03953197824282 21 4 0.00411946446961895 971 10287 4869,5325,85456,10769 NPM1,PLAGL1,TNKS1BP1,PLK2 R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 0.130899306894111 -2.03332690100688 37 6 0.00617919670442842 971 10287 170691,11174,9508,55901,79875,80731 ADAMTS17,ADAMTS6,ADAMTS3,THSD1,THSD4,THSD7B R-HSA-5218920 VEGFR2 mediated vascular permeability 0.13261650307449 -2.02029375139924 29 5 0.00514933058702369 971 10287 5058,57761,10451,10000,4846 PAK1,TRIB3,VAV3,AKT3,NOS3 R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 5567,107 PRKACB,ADCY1 R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-199920 CREB phosphorylation 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 9261,6196 MAPKAPK2,RPS6KA2 R-HSA-171319 Telomere Extension By Telomerase 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 55651,7015 NHP2,TERT R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 30818,3752 KCNIP3,KCND3 R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.135912525159497 -1.99574379754289 7 2 0.00205973223480947 971 10287 83439,4609 TCF7L1,MYC R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.138837112417992 -1.97445388611615 99 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-428540 Activation of Rac 0.139450564899779 -1.97004511400412 14 3 0.00308959835221421 971 10287 5058,57144,9353 PAK1,PAK5,SLIT2 R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.139450564899779 -1.97004511400412 14 3 0.00308959835221421 971 10287 22876,9896,8821 INPP5F,FIG4,INPP4B R-HSA-418885 DCC mediated attractive signaling 0.139450564899779 -1.97004511400412 14 3 0.00308959835221421 971 10287 3983,1793,1630 ABLIM1,DOCK1,DCC R-HSA-75105 Fatty Acyl-CoA Biosynthesis 0.143253379706185 -1.94314033060323 55 8 0.0082389289392379 971 10287 2180,6785,79993,55301,83401,9200,2194,6319 ACSL1,ELOVL4,ELOVL7,OLAH,ELOVL3,HACD1,FASN,SCD R-HSA-196854 Metabolism of vitamins and cofactors 0.143777460292027 -1.93948858942978 174 21 0.0216271884654995 971 10287 8875,55034,349565,160428,3949,53354,2194,9672,9446,83594,10560,9227,10082,27010,23475,5167,119391,10840,79646,29967,83666 VNN2,MOCOS,NMNAT3,ALDH1L2,LDLR,PANK1,FASN,SDC3,GSTO1,NUDT12,SLC19A2,LRAT,GPC6,TPK1,QPRT,ENPP1,GSTO2,ALDH1L1,PANK3,LRP12,PARP9 R-HSA-168255 Influenza Life Cycle 0.144980286672112 -1.93115749978957 146 18 0.0185375901132853 971 10287 6224,6154,5611,3843,6144,821,23521,6164,5903,6136,6158,6205,2963,6206,6124,51121,6228,6207 RPS20,RPL26,DNAJC3,IPO5,RPL21,CANX,RPL13A,RPL34,RANBP2,RPL12,RPL28,RPS11,GTF2F2,RPS12,RPL4,RPL26L1,RPS23,RPS13 R-HSA-8853659 RET signaling 0.145505279797032 -1.92754290576413 270 31 0.0319258496395469 971 10287 2264,9260,54756,685,2335,9462,1850,9693,1852,22821,8822,5578,55816,2260,8660,10718,5924,3690,2906,3082,153090,2887,399473,4684,4233,2674,10125,5159,5567,9846,1843 FGFR4,PDLIM7,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,PRKCA,DOK5,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,GRB10,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,PRKACB,GAB2,DUSP1 R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.147207006555791 -1.9159154749357 137 17 0.0175077239958805 971 10287 6224,6154,5611,3843,6144,23521,6164,5903,6136,6158,6205,2963,6206,6124,51121,6228,6207 RPS20,RPL26,DNAJC3,IPO5,RPL21,RPL13A,RPL34,RANBP2,RPL12,RPL28,RPS11,GTF2F2,RPS12,RPL4,RPL26L1,RPS23,RPS13 R-HSA-381042 PERK regulates gene expression 0.147536127168502 -1.91368220323676 30 5 0.00514933058702369 971 10287 467,440,468,9709,1649 ATF3,ASNS,ATF4,HERPUD1,DDIT3 R-HSA-4641263 Regulation of FZD by ubiquitination 0.147808702194825 -1.9118363940225 22 4 0.00411946446961895 971 10287 4040,55366,8322,8325 LRP6,LGR4,FZD4,FZD8 R-HSA-1250196 SHC1 events in ERBB2 signaling 0.147808702194825 -1.9118363940225 22 4 0.00411946446961895 971 10287 685,10718,5578,5580 BTC,NRG3,PRKCA,PRKCD R-HSA-180292 GAB1 signalosome 0.149337121300093 -1.90154896970813 128 16 0.0164778578784758 971 10287 2264,685,5829,3164,192670,1147,8822,2260,8660,57761,10718,118788,10000,3082,4233,5159 FGFR4,BTC,PXN,NR4A1,AGO4,CHUK,FGF17,FGFR1,IRS2,TRIB3,NRG3,PIK3AP1,AKT3,HGF,MET,PDGFRB R-HSA-382551 Transmembrane transport of small molecules 0.150887886934416 -1.89121818856804 677 72 0.0741503604531411 971 10287 10396,55283,119,6542,114134,28232,84679,51310,5002,6567,7220,154091,55240,5567,6520,10257,285335,64116,107,5577,1244,481,10110,444,57205,23516,6541,5903,540,59345,41,150159,55970,55129,6536,10079,2561,90423,2566,2570,9990,6507,255231,23657,23461,23678,112,6446,55117,353189,79815,85414,490,54795,30061,206358,6262,94015,23250,11182,8140,3099,3098,55356,6510,7222,117247,493,478,8501,2040,9619 ATP8A1,MCOLN3,ADD2,SLC7A2,SLC2A13,SLCO3A1,SLC9A7,SLC22A17,SLC22A18,SLC16A2,TRPC1,SLC2A12,STEAP3,PRKACB,SLC3A2,ABCC4,SLC9C1,SLC39A8,ADCY1,PRKAR2B,ABCC2,ATP1B1,SGK2,ASPH,ATP10D,SLC39A14,SLC7A1,RANBP2,ATP7B,GNB4,ASIC1,SLC9B1,GNG12,ANO10,SLC6A9,ATP9A,GABRB2,ATP6V1E2,GABRG2,GABRR2,SLC12A6,SLC1A3,MCOLN2,SLC7A11,ABCA5,SGK3,ADCY6,SGK1,SLC6A15,SLCO4C1,NIPAL2,SLC45A3,ATP2B1,TRPM4,SLC40A1,SLC36A1,RYR2,TTYH2,ATP11A,SLC2A6,SLC7A5,HK2,HK1,SLC22A15,SLC1A5,TRPC3,SLC16A10,ATP2B4,ATP1A3,SLC43A1,STOM,ABCG1 R-HSA-451927 Interleukin-2 signaling 0.153630546262684 -1.87320460914268 262 30 0.0308959835221421 971 10287 2264,54756,685,3636,2335,9462,1850,9693,5777,1852,22821,6777,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4684,4233,2674,6850,10125,5159,9846,1843 FGFR4,IL17RD,BTC,INPPL1,FN1,RASAL2,DUSP8,RAPGEF2,PTPN6,DUSP9,RASA3,STAT5B,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,GFRA1,SYK,RASGRP1,PDGFRB,GAB2,DUSP1 R-HSA-977443 GABA receptor activation 0.1542141943229 -1.8694127707087 56 8 0.0082389289392379 971 10287 2566,112,55970,3761,2570,2561,2770,107 GABRG2,ADCY6,GNG12,KCNJ4,GABRR2,GABRB2,GNAI1,ADCY1 R-HSA-5578775 Ion homeostasis 0.1542141943229 -1.8694127707087 56 8 0.0082389289392379 971 10287 6262,7220,3709,481,444,493,490,478 RYR2,TRPC1,ITPR2,ATP1B1,ASPH,ATP2B4,ATP2B1,ATP1A3 R-HSA-168254 Influenza Infection 0.15539825775899 -1.86176405244355 157 19 0.01956745623069 971 10287 6224,6154,5611,3843,6144,821,23521,6164,5903,6136,6158,3839,6205,2963,6206,6124,51121,6228,6207 RPS20,RPL26,DNAJC3,IPO5,RPL21,CANX,RPL13A,RPL34,RANBP2,RPL12,RPL28,KPNA3,RPS11,GTF2F2,RPS12,RPL4,RPL26L1,RPS23,RPS13 R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 3992,2180,83401 FADS1,ACSL1,ELOVL3 R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 3992,2180,83401 FADS1,ACSL1,ELOVL3 R-HSA-4419969 Depolymerisation of the Nuclear Lamina 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 64900,5578,5579 LPIN3,PRKCA,PRKCB R-HSA-170670 Adenylate cyclase inhibitory pathway 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 112,2770,107 ADCY6,GNAI1,ADCY1 R-HSA-997269 Inhibition of adenylate cyclase pathway 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 112,2770,107 ADCY6,GNAI1,ADCY1 R-HSA-975577 N-Glycan antennae elongation 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 6480,11282,9331 ST6GAL1,MGAT4B,B4GALT6 R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 4040,83999,22943 LRP6,KREMEN1,DKK1 R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.162738752133295 -1.81560911159792 15 3 0.00308959835221421 971 10287 5578,5579,8322 PRKCA,PRKCB,FZD4 R-HSA-5339562 Uptake and actions of bacterial toxins 0.163129781126255 -1.81320919174846 31 5 0.00514933058702369 971 10287 118429,9899,6616,1938,5608 ANTXR2,SV2B,SNAP25,EEF2,MAP2K6 R-HSA-3858494 Beta-catenin independent WNT signaling 0.16509916578955 -1.80120898082745 149 18 0.0185375901132853 971 10287 55970,8322,8325,144165,192670,7481,3709,4919,5578,23236,5881,83439,5579,2775,59345,5592,5593,8321 GNG12,FZD4,FZD8,PRICKLE1,AGO4,WNT11,ITPR2,ROR1,PRKCA,PLCB1,RAC3,TCF7L1,PRKCB,GNAO1,GNB4,PRKG1,PRKG2,FZD1 R-HSA-6802957 Oncogenic MAPK signaling 0.166752125992754 -1.79124684468594 75 10 0.0102986611740474 971 10287 80853,2335,9462,10827,54845,3690,22821,153090,57670,9715 KDM7A,FN1,RASAL2,FAM114A2,ESRP1,ITGB3,RASA3,DAB2IP,KIAA1549,FAM131B R-HSA-2871796 FCERI mediated MAPK activation 0.168955917926391 -1.77811743875615 265 30 0.0308959835221421 971 10287 2264,5058,54756,685,10451,2335,9462,1850,9693,1852,22821,8822,3937,2260,8660,10718,5924,3690,2906,3082,153090,399473,4684,4233,5602,2674,6850,10125,5159,1843 FGFR4,PAK1,IL17RD,BTC,VAV3,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,LCP2,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,MAPK10,GFRA1,SYK,RASGRP1,PDGFRB,DUSP1 R-HSA-196836 Vitamin C (ascorbate) metabolism 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 9446,119391 GSTO1,GSTO2 R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 5578,5580 PRKCA,PRKCD R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 953,57089 ENTPD1,ENTPD7 R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 875,1491 CBS,CTH R-HSA-196783 Coenzyme A biosynthesis 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 79646,53354 PANK3,PANK1 R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 1573,1545 CYP2J2,CYP1B1 R-HSA-5362798 Release of Hh-Np from the secreting cell 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 147111,85455 NOTUM,DISP2 R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.170318901928839 -1.77008270552409 8 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-199418 Negative regulation of the PI3K/AKT network 0.173683839401166 -1.75051864747745 94 12 0.0123583934088568 971 10287 2264,8660,57761,685,10718,118788,10000,3082,8822,4233,5159,2260 FGFR4,IRS2,TRIB3,BTC,NRG3,PIK3AP1,AKT3,HGF,FGF17,MET,PDGFRB,FGFR1 R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.176904332680191 -1.73214618585973 76 10 0.0102986611740474 971 10287 55160,10451,9826,27018,5924,23263,57580,84033,26230,26084 ARHGEF10L,VAV3,ARHGEF11,BEX3,RASGRF2,MCF2L,PREX1,OBSCN,TIAM2,ARHGEF26 R-HSA-451326 Activation of Kainate Receptors upon glutamate binding 0.179347266838793 -1.71843131437955 32 5 0.00514933058702369 971 10287 55970,2900,23236,2898,59345 GNG12,GRIK4,PLCB1,GRIK2,GNB4 R-HSA-1592389 Activation of Matrix Metalloproteinases 0.179347266838793 -1.71843131437955 32 5 0.00514933058702369 971 10287 80781,4324,4325,50859,1515 COL18A1,MMP15,MMP16,SPOCK3,CTSV R-HSA-916853 Degradation of GABA 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 18 ABAT R-HSA-168268 Virus Assembly and Release 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 821 CANX R-HSA-192905 vRNP Assembly 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 3843 IPO5 R-HSA-6804754 Regulation of TP53 Expression 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 639 PRDM1 R-HSA-190872 Transport of connexons to the plasma membrane 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 2706 GJB2 R-HSA-168316 Assembly of Viral Components at the Budding Site 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 821 CANX R-HSA-428559 Proton-coupled neutral amino acid transporters 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 206358 SLC36A1 R-HSA-203754 NOSIP mediated eNOS trafficking 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 4846 NOS3 R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 4128 MAOA R-HSA-5602566 TICAM1 deficiency - HSE 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 7098 TLR3 R-HSA-5602636 IKBKB deficiency causes SCID 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-8849175 Threonine catabolism 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 23464 GCAT R-HSA-111995 phospho-PLA2 pathway 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 5321 PLA2G4A R-HSA-451307 Activation of Na-permeable Kainate Receptors 0.179880611363538 -1.71546191835549 2 1 0.00102986611740474 971 10287 2898 GRIK2 R-HSA-5218921 VEGFR2 mediated cell proliferation 0.183906345935105 -1.69332864043539 258 29 0.0298661174047374 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,3709,8822,5578,2260,8660,10718,5579,5924,5580,3690,2906,3082,153090,399473,4684,4233,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,ITPR2,FGF17,PRKCA,FGFR1,IRS2,NRG3,PRKCB,RASGRF2,PRKCD,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.185751054976116 -1.68334791585199 24 4 0.00411946446961895 971 10287 1147,7098,7099,10333 CHUK,TLR3,TLR4,TLR6 R-HSA-5260271 Diseases of Immune System 0.185751054976116 -1.68334791585199 24 4 0.00411946446961895 971 10287 1147,7098,7099,10333 CHUK,TLR3,TLR4,TLR6 R-HSA-5620924 Intraflagellar transport 0.185751513488592 -1.68334544743043 41 6 0.00617919670442842 971 10287 92104,28981,79659,150737,57728,51626 TTC30A,IFT81,DYNC2H1,TTC30B,WDR19,DYNC2LI1 R-HSA-1170546 Prolactin receptor signaling 0.187077502805684 -1.67623229448335 16 3 0.00308959835221421 971 10287 6777,8945,2690 STAT5B,BTRC,GHR R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.188604704994314 -1.66810196214637 50 7 0.00720906282183316 971 10287 5287,3636,59338,84725,5783,54477,8821 PIK3C2B,INPPL1,PLEKHA1,PLEKHA8,PTPN13,PLEKHA5,INPP4B R-HSA-72689 Formation of a pool of free 40S subunits 0.189150439687544 -1.66521260336156 105 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-1630316 Glycosaminoglycan metabolism 0.190663129555299 -1.65724712772592 124 15 0.0154479917610711 971 10287 10090,337876,10855,64131,222537,9672,92126,9953,22856,63827,10082,11285,26035,266722,9331 UST,CHSY3,HPSE,XYLT1,HS3ST5,SDC3,DSEL,HS3ST3B1,CHSY1,BCAN,GPC6,B4GALT7,GLCE,HS6ST3,B4GALT6 R-HSA-1989781 PPARA activates gene expression 0.190663129555299 -1.65724712772592 124 15 0.0154479917610711 971 10287 57491,3992,57761,2180,3157,29841,25937,6720,2274,6604,10413,9443,10891,26230,3156 AHRR,FADS1,TRIB3,ACSL1,HMGCS1,GRHL1,WWTR1,SREBF1,FHL2,SMARCD3,YAP1,MED7,PPARGC1A,TIAM2,HMGCR R-HSA-392518 Signal amplification 0.196135646003552 -1.62894878767593 33 5 0.00514933058702369 971 10287 5321,55970,5028,59345,2770 PLA2G4A,GNG12,P2RY1,GNB4,GNAI1 R-HSA-1257604 PIP3 activates AKT signaling 0.199071638967625 -1.61409052422804 125 15 0.0154479917610711 971 10287 2264,8660,57761,685,10718,118788,3164,10000,192670,3082,1147,8822,4233,5159,2260 FGFR4,IRS2,TRIB3,BTC,NRG3,PIK3AP1,NR4A1,AKT3,AGO4,HGF,CHUK,FGF17,MET,PDGFRB,FGFR1 R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling 0.202027299008709 -1.59935244710454 271 30 0.0308959835221421 971 10287 2264,54756,685,3636,2335,9462,1850,9693,5777,1852,22821,6777,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4684,4233,2674,6850,10125,5159,9846,1843 FGFR4,IL17RD,BTC,INPPL1,FN1,RASAL2,DUSP8,RAPGEF2,PTPN6,DUSP9,RASA3,STAT5B,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,GFRA1,SYK,RASGRP1,PDGFRB,GAB2,DUSP1 R-HSA-416482 G alpha (12/13) signalling events 0.205613266988005 -1.5817582193312 88 11 0.0113285272914521 971 10287 55160,55970,10451,9826,5924,59345,23263,57580,84033,26230,26084 ARHGEF10L,GNG12,VAV3,ARHGEF11,RASGRF2,GNB4,MCF2L,PREX1,OBSCN,TIAM2,ARHGEF26 R-HSA-1251985 Nuclear signaling by ERBB4 0.205790218915226 -1.58089798384854 25 4 0.00411946446961895 971 10287 10413,685,10718,1447 YAP1,BTC,NRG3,CSN2 R-HSA-982772 Growth hormone receptor signaling 0.205790218915226 -1.58089798384854 25 4 0.00411946446961895 971 10287 8660,6777,5777,2690 IRS2,STAT5B,PTPN6,GHR R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.205790218915226 -1.58089798384854 25 4 0.00411946446961895 971 10287 5321,55970,5028,59345 PLA2G4A,GNG12,P2RY1,GNB4 R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 113612,1545 CYP2U1,CYP1B1 R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 5627,2621 PROS1,GAS6 R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 27113,5366 BBC3,PMAIP1 R-HSA-428890 Role of Abl in Robo-Slit signaling 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 10486,9353 CAP2,SLIT2 R-HSA-428543 Inactivation of Cdc42 and Rac 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 9353,57522 SLIT2,SRGAP1 R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 4088,9372 SMAD3,ZFYVE9 R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-2214320 Anchoring fibril formation 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 649,7093 BMP1,TLL2 R-HSA-447041 CHL1 interactions 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 8829,3673 NRP1,ITGA2 R-HSA-198693 AKT phosphorylates targets in the nucleus 0.205933635741113 -1.58020131869268 9 2 0.00205973223480947 971 10287 3164,10000 NR4A1,AKT3 R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.2076127556691 -1.5720806860852 107 13 0.0133882595262616 971 10287 6541,6520,23657,206358,8140,55117,6542,9990,6507,6510,84679,117247,8501 SLC7A1,SLC3A2,SLC7A11,SLC36A1,SLC7A5,SLC6A15,SLC7A2,SLC12A6,SLC1A3,SLC1A5,SLC9A7,SLC16A10,SLC43A1 R-HSA-109704 PI3K Cascade 0.208995495544714 -1.56544257966722 79 10 0.0102986611740474 971 10287 2264,8660,5563,57761,1978,55437,81617,8822,2260,58528 FGFR4,IRS2,PRKAA2,TRIB3,EIF4EBP1,STRADB,CAB39L,FGF17,FGFR1,RRAGD R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.211570924723515 -1.55319499522785 372 40 0.0411946446961895 971 10287 685,2335,9462,1850,1147,3709,3937,118788,3690,153090,4684,4233,6850,2674,10125,5159,9846,1843,5058,2264,54756,10451,3164,9693,1852,22821,5588,192670,8822,2260,8660,57761,10718,5924,10000,2906,3082,399473,5602,8945 BTC,FN1,RASAL2,DUSP8,CHUK,ITPR2,LCP2,PIK3AP1,ITGB3,DAB2IP,NCAM1,MET,SYK,GFRA1,RASGRP1,PDGFRB,GAB2,DUSP1,PAK1,FGFR4,IL17RD,VAV3,NR4A1,RAPGEF2,DUSP9,RASA3,PRKCQ,AGO4,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,AKT3,GRIN2D,HGF,SPRED3,MAPK10,BTRC R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 0.212271699791014 -1.54988822207417 17 3 0.00308959835221421 971 10287 23426,5578,5579 GRIP1,PRKCA,PRKCB R-HSA-432142 Platelet sensitization by LDL 0.212271699791014 -1.54988822207417 17 3 0.00308959835221421 971 10287 5321,2268,5777 PLA2G4A,FGR,PTPN6 R-HSA-73847 Purine metabolism 0.213439928821551 -1.54439984973717 34 5 0.00514933058702369 971 10287 64077,161823,4860,122622,270 LHPP,ADAL,PNP,ADSSL1,AMPD1 R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.216058722666685 -1.53220504404873 43 6 0.00617919670442842 971 10287 112,5577,55970,59345,5567,107 ADCY6,PRKAR2B,GNG12,GNB4,PRKACB,ADCY1 R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 0.216392413075704 -1.53066179234852 127 15 0.0154479917610711 971 10287 57491,3992,57761,2180,3157,29841,25937,6720,2274,6604,10413,9443,10891,26230,3156 AHRR,FADS1,TRIB3,ACSL1,HMGCS1,GRHL1,WWTR1,SREBF1,FHL2,SMARCD3,YAP1,MED7,PPARGC1A,TIAM2,HMGCR R-HSA-8856828 Clathrin-mediated endocytosis 0.219848170832127 -1.51481810346213 137 16 0.0164778578784758 971 10287 26052,8322,3949,8673,9829,29763,3092,51429,157,6456,115548,9856,2017,29993,54874,85439 DNM3,FZD4,LDLR,VAMP8,DNAJC6,PACSIN3,HIP1,SNX9,GRK3,SH3GL2,FCHO2,KIAA0319,CTTN,PACSIN1,FNBP1L,STON2 R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.219848170832127 -1.51481810346213 137 16 0.0164778578784758 971 10287 7424,5768,10257,2335,9749,5919,2621,5578,6414,5099,5579,3690,226,3082,5627,5874 VEGFC,QSOX1,ABCC4,FN1,PHACTR2,RARRES2,GAS6,PRKCA,SELENOP,PCDH7,PRKCB,ITGB3,ALDOA,HGF,PROS1,RAB27B R-HSA-912526 Interleukin receptor SHC signaling 0.224629290797529 -1.49330383201287 255 28 0.0288362512873326 971 10287 2264,54756,685,3636,2335,9462,1850,9693,5777,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4684,4233,2674,10125,5159,1843,9846 FGFR4,IL17RD,BTC,INPPL1,FN1,RASAL2,DUSP8,RAPGEF2,PTPN6,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,GAB2 R-HSA-198203 PI3K/AKT activation 0.22529355800889 -1.49035102490039 128 15 0.0154479917610711 971 10287 2264,8660,57761,685,10718,118788,3164,10000,192670,3082,1147,8822,4233,5159,2260 FGFR4,IRS2,TRIB3,BTC,NRG3,PIK3AP1,NR4A1,AKT3,AGO4,HGF,CHUK,FGF17,MET,PDGFRB,FGFR1 R-HSA-2029485 Role of phospholipids in phagocytosis 0.226416185504787 -1.48538044446292 26 4 0.00411946446961895 971 10287 3709,5337,6850,5580 ITPR2,PLD1,SYK,PRKCD R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 0.226416185504787 -1.48538044446292 26 4 0.00411946446961895 971 10287 6480,9486,11282,9331 ST6GAL1,CHST10,MGAT4B,B4GALT6 R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 0.226416185504787 -1.48538044446292 26 4 0.00411946446961895 971 10287 1147,10399,9099,7132 CHUK,RACK1,USP2,TNFRSF1A R-HSA-6804757 Regulation of TP53 Degradation 0.231203723928802 -1.46445603535514 35 5 0.00514933058702369 971 10287 6446,9099,900,10000,8900 SGK1,USP2,CCNG1,AKT3,CCNA1 R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.238133816927152 -1.43492250732091 18 3 0.00308959835221421 971 10287 958,8792,10673 CD40,TNFRSF11A,TNFSF13B R-HSA-199991 Membrane Trafficking 0.238439780791537 -1.43363849197517 610 63 0.0648815653964985 971 10287 5321,5563,26052,9871,23216,3798,3949,8673,7082,23046,22898,51429,1780,7164,81567,2589,662,89866,3257,9856,57186,10960,54732,22989,2017,83548,29993,134829,4646,79958,5874,54453,1604,23433,54885,51560,8322,287,7039,2706,9265,9829,29763,3092,23682,125058,157,55357,10052,155382,6456,115548,10000,11031,55605,54874,9882,85439,23095,2810,27314,92421,160518 PLA2G4A,PRKAA2,DNM3,SEC24D,TBC1D1,KIF5A,LDLR,VAMP8,TJP1,KIF21B,DENND3,SNX9,DYNC1I1,TPD52L1,TXNDC5,GALNT1,BNIP1,SEC16B,HPS1,KIAA0319,RALGAPA2,LMAN2,TMED9,MYH15,CTTN,COG3,PACSIN1,CLVS2,MYO6,DENND1C,RAB27B,RIN2,CD55,RHOQ,TBC1D8B,RAB6B,FZD4,ANK2,TGFA,GJB2,CYTH3,DNAJC6,PACSIN3,HIP1,RAB38,TBC1D16,GRK3,TBC1D2,GJC1,VPS37D,SH3GL2,FCHO2,AKT3,RAB31,KIF21A,FNBP1L,TBC1D4,STON2,KIF1B,SFN,RAB30,CHMP4C,DENND5B R-HSA-74751 Insulin receptor signalling cascade 0.238467312922437 -1.43352303078244 297 32 0.0329557157569516 971 10287 5563,685,2335,9462,1850,3690,153090,4684,4233,2674,10125,5159,1843,2264,54756,9693,55437,22821,1852,8822,2260,8660,57761,10718,5924,1978,2887,81617,3082,2906,399473,58528 PRKAA2,BTC,FN1,RASAL2,DUSP8,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,STRADB,RASA3,DUSP9,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,EIF4EBP1,GRB10,CAB39L,HGF,GRIN2D,SPRED3,RRAGD R-HSA-162582 Signal Transduction 0.240366420605618 -1.42559076741845 2548 250 0.257466529351184 971 10287 23092,57530,5153,1850,55366,3798,50865,3949,1488,6777,3709,5578,10144,92737,57406,5881,83999,6497,55160,6196,3690,91851,2017,7253,343171,10125,5567,5159,1604,1285,4093,130399,79971,120892,10413,192670,5577,93,8822,4919,60485,157,10082,26084,2770,285601,83439,3071,644150,5924,59345,7132,153,79822,5603,81617,5021,8829,58528,4208,5125,5563,26524,6004,55970,2335,9886,285440,4983,90423,10319,7082,5217,2619,1123,3480,118788,23767,10846,4609,57522,23596,5592,4040,112,4684,1298,114793,2674,29967,23432,1131,4846,2264,8643,5058,11245,54756,23433,9047,1286,11069,26086,1852,10203,9672,84033,23286,55437,5151,390442,202559,23236,10458,747,9261,6456,29941,56937,26508,7060,57728,399473,85455,7222,2810,643,5321,685,26052,154810,9462,1793,29984,23543,8477,58504,8601,85415,5596,79339,1147,2870,9372,26230,1592,2838,8555,51339,65055,92,153090,5144,4233,9846,8321,2735,27152,2241,1292,51466,5163,1447,10076,79924,8322,5777,57580,107,7481,25776,5588,26108,2260,3363,4088,8660,5903,57584,3627,10718,5795,27018,5579,1978,3912,25937,3673,6001,3082,2887,657,23462,1272,282763,10810,1299,9170,659,9826,8325,54845,1287,147111,5028,5585,6000,9912,4734,84144,26575,1124,23263,5580,2963,5593,79659,128239,4091,10253,6850,2242,5046,1843,7424,92597,10451,116984,9099,5829,3164,9693,144165,22821,10399,9743,3953,9227,22943,2861,2591,57761,85440,391195,7015,64748,10000,2775,2906,8945 ARHGAP26,CGN,PDE1B,DUSP8,LGR4,KIF5A,HEBP1,LDLR,CTBP2,STAT5B,ITPR2,PRKCA,FAM13A,DNER,ABHD6,RAC3,KREMEN1,SKI,ARHGEF10L,RPS6KA2,ITGB3,CHRDL1,CTTN,TSHR,OR2W3,RASGRP1,PRKACB,PDGFRB,CD55,COL4A3,SMAD9,ACVR1C,WLS,LRRK2,YAP1,AGO4,PRKAR2B,ACVR2B,FGF17,ROR1,SAV1,GRK3,GPC6,ARHGEF26,GNAI1,GPR150,TCF7L1,NCKAP1L,WIPF3,RASGRF2,GNB4,TNFRSF1A,ADRB1,ARHGAP28,MAPK13,CAB39L,OXTR,NRP1,RRAGD,MEF2C,PCSK5,PRKAA2,LATS2,RGS16,GNG12,FN1,RHOBTB1,CYP4V2,OPHN1,ATP6V1E2,LAMC3,TJP1,PFN2,GAS1,CHN1,IGF1R,PIK3AP1,FLRT3,PDE10A,MYC,SRGAP1,OPN3,PRKG1,LRP6,ADCY6,NCAM1,COL9A2,FMNL2,GFRA1,LRP12,GPR161,CHRM3,NOS3,FGFR4,PTCH2,PAK1,GPR176,IL17RD,RHOQ,SH2D2A,COL4A4,RAPGEF4,GPSM1,DUSP9,CALCRL,SDC3,OBSCN,WWC1,STRADB,PDE8A,OR11H4,KHDRBS2,PLCB1,BAIAP2,DAGLA,MAPKAPK2,SH3GL2,PKN3,PMEPA1,HEYL,THBS4,WDR19,SPRED3,DISP2,TRPC3,SFN,CXCR5,PLA2G4A,BTC,DNM3,AMOTL1,RASAL2,DOCK1,RHOD,RBFOX2,GPR65,ARHGAP22,RGS20,RHPN2,MAPK4,OR51B4,CHUK,GRK6,ZFYVE9,TIAM2,CYP26A1,GPR15,CDC14B,DACT1,REEP1,ACVR2A,DAB2IP,PDE4D,MET,GAB2,FZD1,GLI1,INTU,FER,COL6A2,EVL,PDK1,CSN2,PTPRU,ADM2,FZD4,PTPN6,PREX1,ADCY1,WNT11,CBY1,PRKCQ,PYGO1,FGFR1,HTR7,SMAD3,IRS2,RANBP2,ARHGAP21,CXCL10,NRG3,PTPRJ,BEX3,PRKCB,EIF4EBP1,LAMB1,WWTR1,ITGA2,RGS10,HGF,GRB10,BMPR1A,HEY1,CNTN1,OR51B5,WASF3,COL9A3,LPAR2,BMPR2,ARHGEF11,FZD8,ESRP1,COL4A5,NOTUM,P2RY1,PKN1,RGS7,ARHGAP44,NEDD4,SYDE2,RGS17,CHN2,MCF2L,PRKCD,GTF2F2,PRKG2,DYNC2H1,IQGAP3,SMAD6,SPRY2,SYK,FES,PCSK6,DUSP1,VEGFC,MOB1B,VAV3,ARAP2,USP2,PXN,NR4A1,RAPGEF2,PRICKLE1,RASA3,RACK1,ARHGAP32,LEPR,LRAT,DKK1,GPR37,GALNT3,TRIB3,DOCK7,OR2T33,TERT,PLPPR2,AKT3,GNAO1,GRIN2D,BTRC R-HSA-8875656 MET receptor recycling 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 5563,10891 PRKAA2,PPARGC1A R-HSA-168799 Neurotoxicity of clostridium toxins 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 9899,6616 SV2B,SNAP25 R-HSA-1250342 PI3K events in ERBB4 signaling 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-74749 Signal attenuation 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 8660,2887 IRS2,GRB10 R-HSA-442380 Zinc influx into cells by the SLC39 gene family 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 23516,64116 SLC39A14,SLC39A8 R-HSA-419812 Calcitonin-like ligand receptors 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 10203,79924 CALCRL,ADM2 R-HSA-2562578 TRIF-mediated programmed cell death 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 7098,7099 TLR3,TLR4 R-HSA-170660 Adenylate cyclase activating pathway 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 112,107 ADCY6,ADCY1 R-HSA-159740 Gamma-carboxylation of protein precursors 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 5627,2621 PROS1,GAS6 R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.242222772897487 -1.41789742710781 10 2 0.00205973223480947 971 10287 5627,2621 PROS1,GAS6 R-HSA-75109 Triglyceride Biosynthesis 0.243284889476308 -1.41352213767167 82 10 0.0102986611740474 971 10287 2180,6785,56895,79993,55301,83401,9200,2194,6319,64900 ACSL1,ELOVL4,AGPAT4,ELOVL7,OLAH,ELOVL3,HACD1,FASN,SCD,LPIN3 R-HSA-2428924 IGF1R signaling cascade 0.24453888827509 -1.40838093046482 298 32 0.0329557157569516 971 10287 5563,685,2335,9462,1850,3480,3690,153090,4684,4233,2674,10125,5159,1843,2264,54756,9693,55437,22821,1852,8822,2260,8660,57761,10718,5924,1978,81617,3082,2906,399473,58528 PRKAA2,BTC,FN1,RASAL2,DUSP8,IGF1R,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,STRADB,RASA3,DUSP9,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,EIF4EBP1,CAB39L,HGF,GRIN2D,SPRED3,RRAGD R-HSA-2428928 IRS-related events triggered by IGF1R 0.24453888827509 -1.40838093046482 298 32 0.0329557157569516 971 10287 5563,685,2335,9462,1850,3480,3690,153090,4684,4233,2674,10125,5159,1843,2264,54756,9693,55437,22821,1852,8822,2260,8660,57761,10718,5924,1978,81617,3082,2906,399473,58528 PRKAA2,BTC,FN1,RASAL2,DUSP8,IGF1R,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,STRADB,RASA3,DUSP9,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,EIF4EBP1,CAB39L,HGF,GRIN2D,SPRED3,RRAGD R-HSA-432720 Lysosome Vesicle Biogenesis 0.24936984429939 -1.38881816604039 36 5 0.00514933058702369 971 10287 134829,6456,8673,9829,81567 CLVS2,SH3GL2,VAMP8,DNAJC6,TXNDC5 R-HSA-445355 Smooth Muscle Contraction 0.24936984429939 -1.38881816604039 36 5 0.00514933058702369 971 10287 59,10174,10580,5829,7168 ACTA2,SORBS3,SORBS1,PXN,TPM1 R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.250678387628779 -1.38358448563622 299 32 0.0329557157569516 971 10287 5563,685,2335,9462,1850,3480,3690,153090,4684,4233,2674,10125,5159,1843,2264,54756,9693,55437,22821,1852,8822,2260,8660,57761,10718,5924,1978,81617,3082,2906,399473,58528 PRKAA2,BTC,FN1,RASAL2,DUSP8,IGF1R,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,STRADB,RASA3,DUSP9,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,EIF4EBP1,CAB39L,HGF,GRIN2D,SPRED3,RRAGD R-HSA-5683057 MAPK family signaling cascades 0.257057072669455 -1.3584571460976 290 31 0.0319258496395469 971 10287 2264,5058,54756,685,2335,9462,1850,9693,1852,22821,192670,5596,8822,2260,8660,10718,8555,4609,5924,3690,2906,3082,153090,399473,4684,4233,2674,10125,5159,5567,1843 FGFR4,PAK1,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,AGO4,MAPK4,FGF17,FGFR1,IRS2,NRG3,CDC14B,MYC,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,PRKACB,DUSP1 R-HSA-5627083 RHO GTPases regulate CFTR trafficking 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 23433 RHOQ R-HSA-191650 Regulation of gap junction activity 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 7082 TJP1 R-HSA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 7082 TJP1 R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2260 FGFR1 R-HSA-379397 Enzymatic degradation of dopamine by COMT 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 4128 MAOA R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 10644 IGF2BP2 R-HSA-3304347 Loss of Function of SMAD4 in Cancer 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 4088 SMAD3 R-HSA-190704 Oligomerization of connexins into connexons 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2706 GJB2 R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 7358 UGDH R-HSA-5339700 TCF7L2 mutants don't bind CTBP 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 1488 CTBP2 R-HSA-977442 GABA A (rho) receptor activation 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2570 GABRR2 R-HSA-190374 FGFR1c and Klotho ligand binding and activation 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2260 FGFR1 R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 4128 MAOA R-HSA-5602571 TRAF3 deficiency - HSE 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 7098 TLR3 R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 4088 SMAD3 R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-190827 Transport of connexins along the secretory pathway 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2706 GJB2 R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2735 GLI1 R-HSA-5250971 Toxicity of botulinum toxin type C (BoNT/C) 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 6616 SNAP25 R-HSA-1307965 betaKlotho-mediated ligand binding 0.257307536630942 -1.35748326890328 3 1 0.00102986611740474 971 10287 2264 FGFR4 R-HSA-416700 Other semaphorin interactions 0.26448609031438 -1.32996661767009 19 3 0.00308959835221421 971 10287 5788,57556,5362 PTPRC,SEMA6A,PLXNA2 R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 0.26448609031438 -1.32996661767009 19 3 0.00308959835221421 971 10287 9672,63827,10082 SDC3,BCAN,GPC6 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 0.26448609031438 -1.32996661767009 19 3 0.00308959835221421 971 10287 9672,63827,10082 SDC3,BCAN,GPC6 R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 0.26448609031438 -1.32996661767009 19 3 0.00308959835221421 971 10287 9672,63827,10082 SDC3,BCAN,GPC6 R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.26448609031438 -1.32996661767009 19 3 0.00308959835221421 971 10287 18,6616,6812 ABAT,SNAP25,STXBP1 R-HSA-438064 Post NMDA receptor activation events 0.267880865766429 -1.31721292802663 37 5 0.00514933058702369 971 10287 2906,6196,5924,5567,107 GRIN2D,RPS6KA2,RASGRF2,PRKACB,ADCY1 R-HSA-5576893 Phase 2 - plateau phase 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 10368,785,783,781 CACNG3,CACNB4,CACNB2,CACNA2D1 R-HSA-1483191 Synthesis of PC 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 64900,590,84879,10400 LPIN3,BCHE,MFSD2A,PEMT R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 7098,219699,7099,1630 TLR3,UNC5B,TLR4,DCC R-HSA-437239 Recycling pathway of L1 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 26052,6196,6456,57698 DNM3,RPS6KA2,SH3GL2,SHTN1 R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 5563,55437,81617,58528 PRKAA2,STRADB,CAB39L,RRAGD R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.269054744332273 -1.31284040955686 28 4 0.00411946446961895 971 10287 5321,2589,1780,51560 PLA2G4A,GALNT1,DYNC1I1,RAB6B R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism 0.277917288426296 -1.28043173320686 253 27 0.0278063851699279 971 10287 5563,3992,2180,6785,56895,79993,55301,83401,9200,2194,2274,6604,10413,6319,64900,26230,57491,57761,3157,29841,25937,6720,56898,9443,10891,6296,3156 PRKAA2,FADS1,ACSL1,ELOVL4,AGPAT4,ELOVL7,OLAH,ELOVL3,HACD1,FASN,FHL2,SMARCD3,YAP1,SCD,LPIN3,TIAM2,AHRR,TRIB3,HMGCS1,GRHL1,WWTR1,SREBF1,BDH2,MED7,PPARGC1A,ACSM3,HMGCR R-HSA-2586552 Signaling by Leptin 0.277917288426296 -1.28043173320686 253 27 0.0278063851699279 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,6777,8822,3953,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,STAT5B,FGF17,LEPR,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 1147,57161 CHUK,PELI2 R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 7099,10333 TLR4,TLR6 R-HSA-937039 IRAK1 recruits IKK complex 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 1147,57161 CHUK,PELI2 R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 7099,10333 TLR4,TLR6 R-HSA-549127 Organic cation transport 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 55356,5002 SLC22A15,SLC22A18 R-HSA-8851805 MET activates RAS signaling 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 3082,4233 HGF,MET R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-418889 Ligand-independent caspase activation via DCC 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 219699,1630 UNC5B,DCC R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.278742216386395 -1.27746787987518 11 2 0.00205973223480947 971 10287 5627,2621 PROS1,GAS6 R-HSA-1483249 Inositol phosphate metabolism 0.28096493373555 -1.26952540841212 47 6 0.00617919670442842 971 10287 170685,51477,3636,23236,3628,8821 NUDT10,ISYNA1,INPPL1,PLCB1,INPP1,INPP4B R-HSA-112399 IRS-mediated signalling 0.282952881991284 -1.26247488993113 294 31 0.0319258496395469 971 10287 2264,5563,54756,685,2335,9462,1850,9693,1852,22821,55437,8822,2260,8660,57761,10718,1978,5924,3690,2906,3082,81617,153090,399473,4684,4233,2674,10125,5159,58528,1843 FGFR4,PRKAA2,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,STRADB,FGF17,FGFR1,IRS2,TRIB3,NRG3,EIF4EBP1,RASGRF2,ITGB3,GRIN2D,HGF,CAB39L,DAB2IP,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,RRAGD,DUSP1 R-HSA-76009 Platelet Aggregation (Plug Formation) 0.286679635803019 -1.24938993825272 38 5 0.00514933058702369 971 10287 2335,6850,10125,3690,11069 FN1,SYK,RASGRP1,ITGB3,RAPGEF4 R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.288396081178706 -1.24342046180962 115 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-73923 Lipid digestion, mobilization, and transport 0.288396081178706 -1.24342046180962 115 13 0.0133882595262616 971 10287 8435,7436,3949,2172,649,10577,57552,5360,5567,9619,5125,23491,5046 SOAT2,VLDLR,LDLR,FABP6,BMP1,NPC2,NCEH1,PLTP,PRKACB,ABCG1,PCSK5,CES3,PCSK6 R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.289918606890768 -1.23815506128956 57 7 0.00720906282183316 971 10287 6456,54885,51429,7164,8673,9829,81567 SH3GL2,TBC1D8B,SNX9,TPD52L1,VAMP8,DNAJC6,TXNDC5 R-HSA-72737 Cap-dependent Translation Initiation 0.290160460112015 -1.23732119829047 125 14 0.0144181256436663 971 10287 6224,6154,6136,6158,6205,1978,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,EIF4EBP1,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-72613 Eukaryotic Translation Initiation 0.290160460112015 -1.23732119829047 125 14 0.0144181256436663 971 10287 6224,6154,6136,6158,6205,1978,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,EIF4EBP1,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-1482839 Acyl chain remodelling of PE 0.290884862924293 -1.23482775015871 29 4 0.00411946446961895 971 10287 5321,63874,129642,57110 PLA2G4A,ABHD4,MBOAT2,HRASLS R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.290884862924293 -1.23482775015871 29 4 0.00411946446961895 971 10287 6604,10413,860,25937 SMARCD3,YAP1,RUNX2,WWTR1 R-HSA-196807 Nicotinate metabolism 0.290884862924293 -1.23482775015871 29 4 0.00411946446961895 971 10287 349565,83594,83666,23475 NMNAT3,NUDT12,PARP9,QPRT R-HSA-202040 G-protein activation 0.290884862924293 -1.23482775015871 29 4 0.00411946446961895 971 10287 55970,59345,2775,2770 GNG12,GNB4,GNAO1,GNAI1 R-HSA-418217 G beta:gamma signalling through PLC beta 0.291162037911381 -1.23387533547308 20 3 0.00308959835221421 971 10287 55970,23236,59345 GNG12,PLCB1,GNB4 R-HSA-71387 Metabolism of carbohydrates 0.29625884542633 -1.21652172899936 296 31 0.0319258496395469 971 10287 10090,5210,337876,23324,2597,2026,5208,64131,9672,22856,63827,10082,26035,5903,10855,230,226,3099,222537,92126,9953,3098,5106,178,2023,85414,5567,11285,51084,9331,266722 UST,PFKFB4,CHSY3,MAN2B2,GAPDH,ENO2,PFKFB2,XYLT1,SDC3,CHSY1,BCAN,GPC6,GLCE,RANBP2,HPSE,ALDOC,ALDOA,HK2,HS3ST5,DSEL,HS3ST3B1,HK1,PCK2,AGL,ENO1,SLC45A3,PRKACB,B4GALT7,CRYL1,B4GALT6,HS6ST3 R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.297856799847369 -1.21114244539678 48 6 0.00617919670442842 971 10287 2042,1948,10451,2051,2047,1944 EPHA3,EFNB2,VAV3,EPHB6,EPHB1,EFNA3 R-HSA-167044 Signalling to RAS 0.299362548300267 -1.20609990399838 256 27 0.0278063851699279 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,9261,8660,10718,5924,3690,2906,3082,153090,5603,399473,4684,4233,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,MAPKAPK2,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,MAPK13,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.30431325234218 -1.18969767277386 87 10 0.0102986611740474 971 10287 2264,8660,685,10718,118788,3082,8822,4233,5159,2260 FGFR4,IRS2,BTC,NRG3,PIK3AP1,HGF,FGF17,MET,PDGFRB,FGFR1 R-HSA-165159 mTOR signalling 0.305709731483456 -1.18511921714925 39 5 0.00514933058702369 971 10287 5563,55437,81617,1978,58528 PRKAA2,STRADB,CAB39L,EIF4EBP1,RRAGD R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.305709731483456 -1.18511921714925 39 5 0.00514933058702369 971 10287 7220,3709,118788,6850,5777 TRPC1,ITPR2,PIK3AP1,SYK,PTPN6 R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.309979827008472 -1.17124805778658 117 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.309979827008472 -1.17124805778658 117 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-157858 Gap junction trafficking and regulation 0.312938514581087 -1.16174854677672 30 4 0.00411946446961895 971 10287 7082,4646,2706,10052 TJP1,MYO6,GJB2,GJC1 R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.312938514581087 -1.16174854677672 30 4 0.00411946446961895 971 10287 10451,3709,3937,6850 VAV3,ITPR2,LCP2,SYK R-HSA-1475029 Reversible hydration of carbon dioxide 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 760,377677 CA2,CA13 R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 64077,122622 LHPP,ADSSL1 R-HSA-203615 eNOS activation 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 23576,4846 DDAH1,NOS3 R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 8794,3486 TNFRSF10C,IGFBP3 R-HSA-190373 FGFR1c ligand binding and activation 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 2900,2898 GRIK4,GRIK2 R-HSA-3656237 Defective EXT2 causes exostoses 2 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 9672,10082 SDC3,GPC6 R-HSA-451306 Ionotropic activity of Kainate Receptors 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 2900,2898 GRIK4,GRIK2 R-HSA-210990 PECAM1 interactions 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 5777,3690 PTPN6,ITGB3 R-HSA-209822 Glycoprotein hormones 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 3626,83729 INHBC,INHBE R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 9672,10082 SDC3,GPC6 R-HSA-622323 Presynaptic nicotinic acetylcholine receptors 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 5593,4846 PRKG2,NOS3 R-HSA-4641265 Repression of WNT target genes 0.315125547116567 -1.15478415728653 12 2 0.00205973223480947 971 10287 1488,83439 CTBP2,TCF7L1 R-HSA-2024096 HS-GAG degradation 0.318007447328624 -1.14568047720378 21 3 0.00308959835221421 971 10287 9672,10855,10082 SDC3,HPSE,GPC6 R-HSA-2022870 Chondroitin sulfate biosynthesis 0.318007447328624 -1.14568047720378 21 3 0.00308959835221421 971 10287 337876,22856,63827 CHSY3,CHSY1,BCAN R-HSA-500657 Presynaptic function of Kainate receptors 0.318007447328624 -1.14568047720378 21 3 0.00308959835221421 971 10287 55970,23236,59345 GNG12,PLCB1,GNB4 R-HSA-8849932 SALM protein interactions at the synapses 0.318007447328624 -1.14568047720378 21 3 0.00308959835221421 971 10287 5802,2906,5789 PTPRS,GRIN2D,PTPRD R-HSA-210745 Regulation of gene expression in beta cells 0.318007447328624 -1.14568047720378 21 3 0.00308959835221421 971 10287 4825,3174,10000 NKX6-1,HNF4G,AKT3 R-HSA-977444 GABA B receptor activation 0.324915866697114 -1.12418900186665 40 5 0.00514933058702369 971 10287 112,55970,3761,2770,107 ADCY6,GNG12,KCNJ4,GNAI1,ADCY1 R-HSA-991365 Activation of GABAB receptors 0.324915866697114 -1.12418900186665 40 5 0.00514933058702369 971 10287 112,55970,3761,2770,107 ADCY6,GNG12,KCNJ4,GNAI1,ADCY1 R-HSA-109703 PKB-mediated events 0.324915866697114 -1.12418900186665 40 5 0.00514933058702369 971 10287 5563,55437,81617,1978,58528 PRKAA2,STRADB,CAB39L,EIF4EBP1,RRAGD R-HSA-6806834 Signaling by MET 0.325089468249819 -1.12365484761437 69 8 0.0082389289392379 971 10287 85440,5795,6456,3912,3673,10319,3082,4233 DOCK7,PTPRJ,SH3GL2,LAMB1,ITGA2,LAMC3,HGF,MET R-HSA-5653656 Vesicle-mediated transport 0.32664143199723 -1.11889224795756 650 65 0.0669412976313079 971 10287 5321,26052,3798,3949,8673,4481,3512,23046,22898,51429,81567,89866,3257,54732,22989,2017,83548,29993,134829,5874,1604,8322,287,7039,2706,9829,23682,125058,157,10052,85439,27314,92421,160518,5563,23216,9871,7082,7164,1780,2589,662,9856,57186,10960,79958,4646,54453,23433,51560,54885,9265,29763,3092,55357,155382,6456,115548,10000,11031,55605,9882,54874,23095,2810 PLA2G4A,DNM3,KIF5A,LDLR,VAMP8,MSR1,JCHAIN,KIF21B,DENND3,SNX9,TXNDC5,SEC16B,HPS1,TMED9,MYH15,CTTN,COG3,PACSIN1,CLVS2,RAB27B,CD55,FZD4,ANK2,TGFA,GJB2,DNAJC6,RAB38,TBC1D16,GRK3,GJC1,STON2,RAB30,CHMP4C,DENND5B,PRKAA2,TBC1D1,SEC24D,TJP1,TPD52L1,DYNC1I1,GALNT1,BNIP1,KIAA0319,RALGAPA2,LMAN2,DENND1C,MYO6,RIN2,RHOQ,RAB6B,TBC1D8B,CYTH3,PACSIN3,HIP1,TBC1D2,VPS37D,SH3GL2,FCHO2,AKT3,RAB31,KIF21A,TBC1D4,FNBP1L,KIF1B,SFN R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 5829 PXN R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 475 ATOX1 R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 6507 SLC1A3 R-HSA-379401 Dopamine clearance from the synaptic cleft 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 4128 MAOA R-HSA-1296053 Classical Kir channels 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 3761 KCNJ4 R-HSA-8848584 Wax biosynthesis 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 55711 FAR2 R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 8829 NRP1 R-HSA-6783984 Glycine degradation 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 2731 GLDC R-HSA-211163 AKT-mediated inactivation of FOXO1A 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 10000 AKT3 R-HSA-140179 Amine Oxidase reactions 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 4128 MAOA R-HSA-165158 Activation of AKT2 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 57761 TRIB3 R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 7020 TFAP2A R-HSA-112313 Neurotransmitter uptake and Metabolism In Glial Cells 0.327431455525215 -1.11647654191853 4 1 0.00102986611740474 971 10287 6507 SLC1A3 R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.329734378074607 -1.109467863565 89 10 0.0102986611740474 971 10287 54453,3257,51560,10000,11031,23682,5874,79958,22898,160518 RIN2,HPS1,RAB6B,AKT3,RAB31,RAB38,RAB27B,DENND1C,DENND3,DENND5B R-HSA-1483206 Glycerophospholipid biosynthesis 0.332001682312049 -1.10261524287352 129 14 0.0144181256436663 971 10287 5321,590,54947,84879,10400,56895,114879,5337,64900,63874,129642,64850,1040,57110 PLA2G4A,BCHE,LPCAT2,MFSD2A,PEMT,AGPAT4,OSBPL5,PLD1,LPIN3,ABHD4,MBOAT2,ETNPPL,CDS1,HRASLS R-HSA-74752 Signaling by Insulin receptor 0.334257617893423 -1.09584327225479 322 33 0.0339855818743563 971 10287 5563,685,2335,9462,1850,90423,3690,153090,4684,4233,2674,10125,5159,1843,2264,54756,9693,1852,55437,22821,8822,2260,8660,57761,10718,5924,1978,2887,81617,3082,2906,399473,58528 PRKAA2,BTC,FN1,RASAL2,DUSP8,ATP6V1E2,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,DUSP9,STRADB,RASA3,FGF17,FGFR1,IRS2,TRIB3,NRG3,RASGRF2,EIF4EBP1,GRB10,CAB39L,HGF,GRIN2D,SPRED3,RRAGD R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.335132401022153 -1.09322959830686 31 4 0.00411946446961895 971 10287 9261,6196,5602,4208 MAPKAPK2,RPS6KA2,MAPK10,MEF2C R-HSA-418360 Platelet calcium homeostasis 0.335132401022153 -1.09322959830686 31 4 0.00411946446961895 971 10287 3709,7222,493,490 ITPR2,TRPC3,ATP2B4,ATP2B1 R-HSA-114452 Activation of BH3-only proteins 0.335132401022153 -1.09322959830686 31 4 0.00411946446961895 971 10287 27113,5366,10000,2810 BBC3,PMAIP1,AKT3,SFN R-HSA-1839124 FGFR1 mutant receptor activation 0.335132401022153 -1.09322959830686 31 4 0.00411946446961895 971 10287 6777,8822,2260,9846 STAT5B,FGF17,FGFR1,GAB2 R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.343088923068636 -1.06976561448694 120 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.343088923068636 -1.06976561448694 120 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 0.344244249084241 -1.06640384715056 41 5 0.00514933058702369 971 10287 2906,6196,5924,5567,107 GRIN2D,RPS6KA2,RASGRF2,PRKACB,ADCY1 R-HSA-203765 eNOS activation and regulation 0.344880933400805 -1.06455604209597 22 3 0.00308959835221421 971 10287 5593,23576,4846 PRKG2,DDAH1,NOS3 R-HSA-166663 Initial triggering of complement 0.344880933400805 -1.06455604209597 22 3 0.00308959835221421 971 10287 715,10584,720 C1R,COLEC10,C4A R-HSA-202131 Metabolism of nitric oxide 0.344880933400805 -1.06455604209597 22 3 0.00308959835221421 971 10287 5593,23576,4846 PRKG2,DDAH1,NOS3 R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 2934,7431 GSN,VIM R-HSA-2029481 FCGR activation 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 2268,6850 FGR,SYK R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 9099,7132 USP2,TNFRSF1A R-HSA-977441 GABA A receptor activation 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 2566,2561 GABRG2,GABRB2 R-HSA-5210891 Uptake and function of anthrax toxins 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 118429,5608 ANTXR2,MAP2K6 R-HSA-198323 AKT phosphorylates targets in the cytosol 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 1147,10000 CHUK,AKT3 R-HSA-171007 p38MAPK events 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 9261,5603 MAPKAPK2,MAPK13 R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 760,51700 CA2,CYB5R2 R-HSA-190239 FGFR3 ligand binding and activation 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 2591,8822 GALNT3,FGF17 R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 760,51700 CA2,CYB5R2 R-HSA-391160 Signal regulatory protein (SIRP) family interactions 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 8935,5777 SKAP2,PTPN6 R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-190372 FGFR3c ligand binding and activation 0.35107334016293 -1.04676013100938 13 2 0.00205973223480947 971 10287 2591,8822 GALNT3,FGF17 R-HSA-187687 Signalling to ERKs 0.35136127483938 -1.04594031180791 263 27 0.0278063851699279 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,9261,8660,10718,5924,3690,2906,3082,153090,5603,399473,4684,4233,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,MAPKAPK2,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,MAPK13,SPRED3,NCAM1,MET,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-6802952 Signaling by BRAF and RAF fusions 0.352594836603082 -1.04243565290584 61 7 0.00720906282183316 971 10287 80853,2335,10827,57670,54845,3690,9715 KDM7A,FN1,FAM114A2,KIAA1549,ESRP1,ITGB3,FAM131B R-HSA-6809371 Formation of the cornified envelope 0.354360965894037 -1.03743920769973 71 8 0.0082389289392379 971 10287 6768,23254,1829,5318,11005,1832,64065,5046 ST14,KAZN,DSG2,PKP2,SPINK5,DSP,PERP,PCSK6 R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.355546938667115 -1.03409800282295 91 10 0.0102986611740474 971 10287 9261,6196,7098,57161,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-109581 Apoptosis 0.358295400358055 -1.02639749215789 172 18 0.0185375901132853 971 10287 1630,7431,5588,7082,1832,6304,8428,2934,7098,5366,10000,1829,5580,27113,219699,7099,100506658,2810 DCC,VIM,PRKCQ,TJP1,DSP,SATB1,STK24,GSN,TLR3,PMAIP1,AKT3,DSG2,PRKCD,BBC3,UNC5B,TLR4,OCLN,SFN R-HSA-3928662 EPHB-mediated forward signaling 0.363642888326253 -1.01158296894226 42 5 0.00514933058702369 971 10287 1948,5058,2051,64283,2047 EFNB2,PAK1,EPHB6,ARHGEF28,EPHB1 R-HSA-1566948 Elastic fibre formation 0.363642888326253 -1.01158296894226 42 5 0.00514933058702369 971 10287 2202,84171,652,2200,3690 EFEMP1,LOXL4,BMP4,FBN1,ITGB3 R-HSA-114608 Platelet degranulation 0.364225022501167 -1.00998340866387 132 14 0.0144181256436663 971 10287 7424,5768,10257,2335,226,3690,9749,3082,5919,2621,5627,5874,6414,5099 VEGFC,QSOX1,ABCC4,FN1,ALDOA,ITGB3,PHACTR2,HGF,RARRES2,GAS6,PROS1,RAB27B,SELENOP,PCDH7 R-HSA-445717 Aquaporin-mediated transport 0.366908429003364 -1.00264297431334 52 6 0.00617919670442842 971 10287 112,5577,55970,59345,5567,107 ADCY6,PRKAR2B,GNG12,GNB4,PRKACB,ADCY1 R-HSA-1445148 Translocation of GLUT4 to the plasma membrane 0.368515535297119 -0.99827241004024 62 7 0.00720906282183316 971 10287 57186,5563,22989,23433,9882,23216,2810 RALGAPA2,PRKAA2,MYH15,RHOQ,TBC1D4,TBC1D1,SFN R-HSA-373080 Class B/2 (Secretin family receptors) 0.368561154249831 -0.998148626576681 92 10 0.0102986611740474 971 10287 8643,55970,1604,8322,79924,59345,8325,10203,7481,8321 PTCH2,GNG12,CD55,FZD4,ADM2,GNB4,FZD8,CALCRL,WNT11,FZD1 R-HSA-381119 Unfolded Protein Response (UPR) 0.368561154249831 -0.998148626576681 92 10 0.0102986611740474 971 10287 440,468,5611,7466,7494,2081,467,55033,1649,9709 ASNS,ATF4,DNAJC3,WFS1,XBP1,ERN1,ATF3,FKBP14,DDIT3,HERPUD1 R-HSA-180336 SHC1 events in EGFR signaling 0.370838875403996 -0.991987608811873 245 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-5673001 RAF/MAP kinase cascade 0.370838875403996 -0.991987608811873 245 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-179812 GRB2 events in EGFR signaling 0.370838875403996 -0.991987608811873 245 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-112412 SOS-mediated signalling 0.370838875403996 -0.991987608811873 245 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.371654151142286 -0.989791558379642 23 3 0.00308959835221421 971 10287 55970,59345,2770 GNG12,GNB4,GNAI1 R-HSA-389977 Post-chaperonin tubulin folding pathway 0.371654151142286 -0.989791558379642 23 3 0.00308959835221421 971 10287 10382,402,7846 TUBB4A,ARL2,TUBA1A R-HSA-112409 RAF-independent MAPK1/3 activation 0.371654151142286 -0.989791558379642 23 3 0.00308959835221421 971 10287 1852,1850,1843 DUSP9,DUSP8,DUSP1 R-HSA-1500931 Cell-Cell communication 0.375079677117264 -0.980616803268068 133 14 0.0144181256436663 971 10287 5058,5829,8935,1630,9069,5777,3655,1015,10979,5603,253559,9863,1000,10207 PAK1,PXN,SKAP2,DCC,CLDN12,PTPN6,ITGA6,CDH17,FERMT2,MAPK13,CADM2,MAGI2,CDH2,PATJ R-HSA-425407 SLC-mediated transmembrane transport 0.377321564212585 -0.974657499622877 287 29 0.0298661174047374 971 10287 30061,6520,6536,206358,64116,6542,6507,9990,114134,28232,84679,23516,6541,5903,23657,5002,6567,11182,8140,3099,154091,55117,55356,3098,6510,353189,85414,117247,8501 SLC40A1,SLC3A2,SLC6A9,SLC36A1,SLC39A8,SLC7A2,SLC1A3,SLC12A6,SLC2A13,SLCO3A1,SLC9A7,SLC39A14,SLC7A1,RANBP2,SLC7A11,SLC22A18,SLC16A2,SLC2A6,SLC7A5,HK2,SLC2A12,SLC6A15,SLC22A15,HK1,SLC1A5,SLCO4C1,SLC45A3,SLC16A10,SLC43A1 R-HSA-202433 Generation of second messenger molecules 0.379629044226951 -0.968560702457425 33 4 0.00411946446961895 971 10287 5058,55740,51466,3937 PAK1,ENAH,EVL,LCP2 R-HSA-5357905 Regulation of TNFR1 signaling 0.379629044226951 -0.968560702457425 33 4 0.00411946446961895 971 10287 1147,10399,9099,7132 CHUK,RACK1,USP2,TNFRSF1A R-HSA-5663202 Diseases of signal transduction 0.379778387733424 -0.968167386558441 370 37 0.0381050463439753 971 10287 685,2335,9462,8325,54845,1147,6777,1488,83999,9372,9715,80853,118788,4609,3690,2963,4040,153090,4233,57670,5159,9846,2264,8322,3164,22821,8822,2260,22943,8660,4088,10718,10827,10000,26508,3082,23462 BTC,FN1,RASAL2,FZD8,ESRP1,CHUK,STAT5B,CTBP2,KREMEN1,ZFYVE9,FAM131B,KDM7A,PIK3AP1,MYC,ITGB3,GTF2F2,LRP6,DAB2IP,MET,KIAA1549,PDGFRB,GAB2,FGFR4,FZD4,NR4A1,RASA3,FGF17,FGFR1,DKK1,IRS2,SMAD3,NRG3,FAM114A2,AKT3,HEYL,HGF,HEY1 R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.381626784737408 -0.963312151259595 93 10 0.0102986611740474 971 10287 9261,6196,7098,57161,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.381626784737408 -0.963312151259595 93 10 0.0102986611740474 971 10287 9261,6196,7098,57161,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.38306185748915 -0.959558795037904 43 5 0.00514933058702369 971 10287 55970,6000,59345,2775,2770 GNG12,RGS7,GNB4,GNAO1,GNAI1 R-HSA-1236394 Signaling by ERBB4 0.38306185748915 -0.959558795037904 43 5 0.00514933058702369 971 10287 10413,685,10718,1447,4734 YAP1,BTC,NRG3,CSN2,NEDD4 R-HSA-421837 Clathrin derived vesicle budding 0.383914768456604 -0.957334708174804 73 8 0.0082389289392379 971 10287 6456,54885,8673,9829,134829,7164,51429,81567 SH3GL2,TBC1D8B,VAMP8,DNAJC6,CLVS2,TPD52L1,SNX9,TXNDC5 R-HSA-199992 trans-Golgi Network Vesicle Budding 0.383914768456604 -0.957334708174804 73 8 0.0082389289392379 971 10287 6456,54885,8673,9829,134829,7164,51429,81567 SH3GL2,TBC1D8B,VAMP8,DNAJC6,CLVS2,TPD52L1,SNX9,TXNDC5 R-HSA-1679131 Trafficking and processing of endosomal TLR 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 7098,1515 TLR3,CTSV R-HSA-1250347 SHC1 events in ERBB4 signaling 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-181431 Acetylcholine Binding And Downstream Events 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-428790 Facilitative Na+-independent glucose transporters 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 154091,11182 SLC2A12,SLC2A6 R-HSA-629602 Activation of Nicotinic Acetylcholine Receptors 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-174403 Glutathione synthesis and recycling 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 26873,79094 OPLAH,CHAC1 R-HSA-209952 Peptide hormone biosynthesis 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 3626,83729 INHBC,INHBE R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 64065,604 PERP,BCL6 R-HSA-418359 Reduction of cytosolic Ca++ levels 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 493,490 ATP2B4,ATP2B1 R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 8973,1138 CHRNA6,CHRNA5 R-HSA-190322 FGFR4 ligand binding and activation 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-419408 Lysosphingolipid and LPA receptors 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 9170,64748 LPAR2,PLPPR2 R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 10000,25946 AKT3,ZNF385A R-HSA-1483213 Synthesis of PE 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 64900,64850 LPIN3,ETNPPL R-HSA-177504 Retrograde neurotrophin signalling 0.38634380270754 -0.951027625348408 14 2 0.00205973223480947 971 10287 26052,6456 DNM3,SH3GL2 R-HSA-5357801 Programmed Cell Death 0.38679498616886 -0.949860477821911 175 18 0.0185375901132853 971 10287 1630,7431,5588,7082,1832,6304,8428,2934,7098,5366,10000,1829,5580,27113,219699,7099,100506658,2810 DCC,VIM,PRKCQ,TJP1,DSP,SATB1,STK24,GSN,TLR3,PMAIP1,AKT3,DSG2,PRKCD,BBC3,UNC5B,TLR4,OCLN,SFN R-HSA-71291 Metabolism of amino acids and derivatives 0.388783328308785 -0.944733087179457 361 36 0.0370751802265705 971 10287 6224,84706,256987,10157,23464,445,875,26227,23521,6164,440,51166,8564,6205,347735,85007,51121,2628,6228,1491,2731,6207,6154,6520,123688,6144,4141,144193,5831,6136,6158,6999,8140,6124,6206,5723 RPS20,GPT2,SERINC5,AASS,GCAT,ASS1,CBS,PHGDH,RPL13A,RPL34,ASNS,AADAT,KMO,RPS11,SERINC2,PHYKPL,RPL26L1,GATM,RPS23,CTH,GLDC,RPS13,RPL26,SLC3A2,HYKK,RPL21,MARS,AMDHD1,PYCR1,RPL12,RPL28,TDO2,SLC7A5,RPL4,RPS12,PSPH R-HSA-390648 Muscarinic acetylcholine receptors 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 1131 CHRM3 R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 2152 F3 R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 202559 KHDRBS2 R-HSA-2161541 Abacavir metabolism 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 161823 ADAL R-HSA-111448 Activation of NOXA and translocation to mitochondria 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 5366 PMAIP1 R-HSA-167827 The proton buffering model 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 9481 SLC25A27 R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 5567 PRKACB R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F) 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 9899 SV2B R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 6296 ACSM3 R-HSA-166187 Mitochondrial Uncoupling Proteins 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 9481 SLC25A27 R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D) 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 9899 SV2B R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 4245 MGAT1 R-HSA-8853383 Lysosomal oligosaccharide catabolism 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 23324 MAN2B2 R-HSA-389599 Alpha-oxidation of phytanate 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 11001 SLC27A2 R-HSA-112303 Electric Transmission Across Gap Junctions 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 10052 GJC1 R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 4846 NOS3 R-HSA-68911 G2 Phase 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-8866376 Reelin signalling pathway 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 7436 VLDLR R-HSA-1169092 Activation of RAS in B cells 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 10125 RASGRP1 R-HSA-112307 Transmission across Electrical Synapses 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 10052 GJC1 R-HSA-167826 The fatty acid cycling model 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 9481 SLC25A27 R-HSA-5661270 Catabolism of glucuronate to xylulose-5-phosphate 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 51084 CRYL1 R-HSA-1483226 Synthesis of PI 0.390940553717271 -0.939199767084215 5 1 0.00102986611740474 971 10287 1040 CDS1 R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.39258121522031 -0.935011845405448 104 11 0.0113285272914521 971 10287 1896,60401,7132,10673,9966,1147,7292,608,958,8792,8945 EDA,EDA2R,TNFRSF1A,TNFSF13B,TNFSF15,CHUK,TNFSF4,TNFRSF17,CD40,TNFRSF11A,BTRC R-HSA-937041 IKK complex recruitment mediated by RIP1 0.398211736302548 -0.920771414399763 24 3 0.00308959835221421 971 10287 1147,7098,7099 CHUK,TLR3,TLR4 R-HSA-8873719 RAB geranylgeranylation 0.400461670715662 -0.915137220634972 64 7 0.00720906282183316 971 10287 5865,23682,5874,51560,27314,25837,11031 RAB3B,RAB38,RAB27B,RAB6B,RAB30,RAB26,RAB31 R-HSA-450294 MAP kinase activation in TLR cascade 0.400461670715662 -0.915137220634972 64 7 0.00720906282183316 971 10287 9261,1147,6196,5602,5608,8945,4208 MAPKAPK2,CHUK,RPS6KA2,MAPK10,MAP2K6,BTRC,MEF2C R-HSA-390522 Striated Muscle Contraction 0.401787592937805 -0.911831705779391 34 4 0.00411946446961895 971 10287 7431,29767,7168,4703 VIM,TMOD2,TPM1,NEB R-HSA-114604 GPVI-mediated activation cascade 0.401799457937104 -0.911802175688564 54 6 0.00617919670442842 971 10287 10451,3937,6850,10000,5777,9846 VAV3,LCP2,SYK,AKT3,PTPN6,GAB2 R-HSA-975634 Retinoid metabolism and transport 0.402453509948319 -0.910175692028521 44 5 0.00514933058702369 971 10287 9672,9227,10082,29967,3949 SDC3,LRAT,GPC6,LRP12,LDLR R-HSA-1660661 Sphingolipid de novo biosynthesis 0.402453509948319 -0.910175692028521 44 5 0.00514933058702369 971 10287 8611,79603,10715,340485,8612 PLPP1,CERS4,CERS1,ACER2,PLPP2 R-HSA-170984 ARMS-mediated activation 0.40303924405558 -0.908721341986036 249 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-187706 Signalling to p38 via RIT and RIN 0.40303924405558 -0.908721341986036 249 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane 0.407851677924995 -0.896851705170221 95 10 0.0102986611740474 971 10287 9261,6196,57161,5608,1147,5602,10333,7099,8945,4208 MAPKAPK2,RPS6KA2,PELI2,MAP2K6,CHUK,MAPK10,TLR6,TLR4,BTRC,MEF2C R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.407851677924995 -0.896851705170221 95 10 0.0102986611740474 971 10287 9261,6196,57161,5608,1147,5602,10333,7099,8945,4208 MAPKAPK2,RPS6KA2,PELI2,MAP2K6,CHUK,MAPK10,TLR6,TLR4,BTRC,MEF2C R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.407851677924995 -0.896851705170221 95 10 0.0102986611740474 971 10287 9261,6196,57161,5608,1147,5602,10333,7099,8945,4208 MAPKAPK2,RPS6KA2,PELI2,MAP2K6,CHUK,MAPK10,TLR6,TLR4,BTRC,MEF2C R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.407851677924995 -0.896851705170221 95 10 0.0102986611740474 971 10287 9261,6196,57161,5608,1147,5602,10333,7099,8945,4208 MAPKAPK2,RPS6KA2,PELI2,MAP2K6,CHUK,MAPK10,TLR6,TLR4,BTRC,MEF2C R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.408880605035054 -0.894332084785744 229 23 0.023686920700309 971 10287 2264,685,3164,5966,5777,192670,1147,3709,8822,2260,8660,57761,10718,118788,5579,10000,7220,3082,4233,6850,10125,8945,5159 FGFR4,BTC,NR4A1,REL,PTPN6,AGO4,CHUK,ITPR2,FGF17,FGFR1,IRS2,TRIB3,NRG3,PIK3AP1,PRKCB,AKT3,TRPC1,HGF,MET,SYK,RASGRP1,BTRC,PDGFRB R-HSA-3781865 Diseases of glycosylation 0.410702388182444 -0.889886443129192 85 9 0.00926879505664264 971 10287 170691,9508,79875,80731,9672,11174,63827,55901,10082 ADAMTS17,ADAMTS3,THSD4,THSD7B,SDC3,ADAMTS6,BCAN,THSD1,GPC6 R-HSA-170968 Frs2-mediated activation 0.411146072091672 -0.88880672107877 250 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-194315 Signaling by Rho GTPases 0.412122406890525 -0.886434869656078 427 42 0.043254376930999 971 10287 23092,10810,9826,9886,29984,3798,58504,4983,85415,5585,10144,5217,5881,9912,26230,84144,55160,1123,1124,23263,57522,2017,128239,114793,5058,10451,116984,51466,23433,57580,84033,9743,10458,26084,5903,57584,29941,3071,644150,5924,79822,2810 ARHGAP26,WASF3,ARHGEF11,RHOBTB1,RHOD,KIF5A,ARHGAP22,OPHN1,RHPN2,PKN1,FAM13A,PFN2,RAC3,ARHGAP44,TIAM2,SYDE2,ARHGEF10L,CHN1,CHN2,MCF2L,SRGAP1,CTTN,IQGAP3,FMNL2,PAK1,VAV3,ARAP2,EVL,RHOQ,PREX1,OBSCN,ARHGAP32,BAIAP2,ARHGEF26,RANBP2,ARHGAP21,PKN3,NCKAP1L,WIPF3,RASGRF2,ARHGAP28,SFN R-HSA-5684996 MAPK1/MAPK3 signaling 0.419268582263042 -0.869243556630048 251 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 3248,9536 HPGD,PTGES R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 4233,6456 MET,SH3GL2 R-HSA-111447 Activation of BAD and translocation to mitochondria 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 10000,2810 AKT3,SFN R-HSA-6785631 ERBB2 Regulates Cell Motility 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-5682910 LGI-ADAM interactions 0.420744579722135 -0.865729328413368 15 2 0.00205973223480947 971 10287 55203,10368 LGI2,CACNG3 R-HSA-379724 tRNA Aminoacylation 0.421772654322129 -0.863288843949156 45 5 0.00514933058702369 971 10287 833,4141,2617,16,7453 CARS,MARS,GARS,AARS,WARS R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.42445103413153 -0.856958629397478 25 3 0.00308959835221421 971 10287 1147,3164,10000 CHUK,NR4A1,AKT3 R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.42445103413153 -0.856958629397478 25 3 0.00308959835221421 971 10287 9261,6196,4208 MAPKAPK2,RPS6KA2,MEF2C R-HSA-425410 Metal ion SLC transporters 0.42445103413153 -0.856958629397478 25 3 0.00308959835221421 971 10287 23516,30061,64116 SLC39A14,SLC40A1,SLC39A8 R-HSA-169893 Prolonged ERK activation events 0.427403278842648 -0.850027264524626 252 25 0.0257466529351184 971 10287 2264,54756,685,2335,9462,1850,9693,1852,22821,8822,2260,8660,10718,5924,3690,2906,3082,153090,399473,4233,4684,2674,10125,5159,1843 FGFR4,IL17RD,BTC,FN1,RASAL2,DUSP8,RAPGEF2,DUSP9,RASA3,FGF17,FGFR1,IRS2,NRG3,RASGRF2,ITGB3,GRIN2D,HGF,DAB2IP,SPRED3,MET,NCAM1,GFRA1,RASGRP1,PDGFRB,DUSP1 R-HSA-15869 Metabolism of nucleotides 0.434102800834803 -0.834473904647638 97 10 0.0102986611740474 971 10287 953,203,1890,161823,4860,57089,205,64077,122622,270 ENTPD1,AK1,TYMP,ADAL,PNP,ENTPD7,AK4,LHPP,ADSSL1,AMPD1 R-HSA-193704 p75 NTR receptor-mediated signalling 0.434102800834803 -0.834473904647638 97 10 0.0102986611740474 971 10287 55160,10451,9826,27018,5924,23263,57580,84033,26230,26084 ARHGEF10L,VAV3,ARHGEF11,BEX3,RASGRF2,MCF2L,PREX1,OBSCN,TIAM2,ARHGEF26 R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.434102800834803 -0.834473904647638 97 10 0.0102986611740474 971 10287 9261,6196,7098,57161,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-449147 Signaling by Interleukins 0.435277570539593 -0.831771358193887 525 51 0.0525231719876416 971 10287 685,3636,9235,2335,9462,1850,3600,2625,1147,3597,6777,8809,4609,3690,604,153090,4684,4233,6850,3556,2674,10125,1052,5159,9846,1843,2264,54756,5777,9693,1852,22821,7431,8822,10538,2260,8660,3627,10718,1435,5924,5608,57161,7132,4128,2906,3082,399473,3977,3581,8945 BTC,INPPL1,IL32,FN1,RASAL2,DUSP8,IL15,GATA3,CHUK,IL13RA1,STAT5B,IL18R1,MYC,ITGB3,BCL6,DAB2IP,NCAM1,MET,SYK,IL1RAP,GFRA1,RASGRP1,CEBPD,PDGFRB,GAB2,DUSP1,FGFR4,IL17RD,PTPN6,RAPGEF2,DUSP9,RASA3,VIM,FGF17,BATF,FGFR1,IRS2,CXCL10,NRG3,CSF1,RASGRF2,MAP2K6,PELI2,TNFRSF1A,MAOA,GRIN2D,HGF,SPRED3,LIFR,IL9R,BTRC R-HSA-446652 Interleukin-1 signaling 0.440976690416565 -0.818763261130494 46 5 0.00514933058702369 971 10287 1147,57161,5608,3556,8945 CHUK,PELI2,MAP2K6,IL1RAP,BTRC R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.445601986058847 -0.808329133334905 36 4 0.00411946446961895 971 10287 10810,3071,644150,10458 WASF3,NCKAP1L,WIPF3,BAIAP2 R-HSA-5336415 Uptake and function of diphtheria toxin 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 1938 EEF2 R-HSA-388479 Vasopressin-like receptors 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 5021 OXTR R-HSA-190370 FGFR1b ligand binding and activation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 2260 FGFR1 R-HSA-1482798 Acyl chain remodeling of CL 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 5321 PLA2G4A R-HSA-5676934 Protein repair 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 253827 MSRB3 R-HSA-1566977 Fibronectin matrix formation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 2335 FN1 R-HSA-947581 Molybdenum cofactor biosynthesis 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 55034 MOCOS R-HSA-5690714 CD22 mediated BCR regulation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 5777 PTPN6 R-HSA-173623 Classical antibody-mediated complement activation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 715 C1R R-HSA-205025 NADE modulates death signalling 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 27018 BEX3 R-HSA-111957 Cam-PDE 1 activation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 5153 PDE1B R-HSA-8857538 PTK6 promotes HIF1A stabilization 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 120892 LRRK2 R-HSA-211916 Vitamins 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 1592 CYP26A1 R-HSA-444257 RSK activation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 6196 RPS6KA2 R-HSA-189483 Heme degradation 0.448458227546913 -0.801939739954885 6 1 0.00102986611740474 971 10287 645 BLVRB R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.450281666558855 -0.797881966341205 26 3 0.00308959835221421 971 10287 9672,63827,10082 SDC3,BCAN,GPC6 R-HSA-975298 Ligand-gated ion channel transport 0.450281666558855 -0.797881966341205 26 3 0.00308959835221421 971 10287 2566,2570,2561 GABRG2,GABRR2,GABRB2 R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.452324168923757 -0.793356168321821 88 9 0.00926879505664264 971 10287 1051,1879,6720,6604,1050,688,9443,10891,1052 CEBPB,EBF1,SREBF1,SMARCD3,CEBPA,KLF5,MED7,PPARGC1A,CEBPD R-HSA-1963640 GRB2 events in ERBB2 signaling 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 1147,8945 CHUK,BTRC R-HSA-1433559 Regulation of KIT signaling 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 5578,5777 PRKCA,PTPN6 R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 2335,3690 FN1,ITGB3 R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 7039,7020 TGFA,TFAP2A R-HSA-5686938 Regulation of TLR by endogenous ligand 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 7099,10333 TLR4,TLR6 R-HSA-446353 Cell-extracellular matrix interactions 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 10979,5829 FERMT2,PXN R-HSA-549132 Organic cation/anion/zwitterion transport 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 55356,5002 SLC22A15,SLC22A18 R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 2335,3690 FN1,ITGB3 R-HSA-190242 FGFR1 ligand binding and activation 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 7098,7099 TLR3,TLR4 R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-1963642 PI3K events in ERBB2 signaling 0.454125590705398 -0.789381487686543 16 2 0.00205973223480947 971 10287 685,10718 BTC,NRG3 R-HSA-190236 Signaling by FGFR 0.466115520396492 -0.763321777731537 89 9 0.00926879505664264 971 10287 2264,2591,23543,23767,54845,2963,8822,10253,2260 FGFR4,GALNT3,RBFOX2,FLRT3,ESRP1,GTF2F2,FGF17,SPRY2,FGFR1 R-HSA-180024 DARPP-32 events 0.475624980025833 -0.743125592361807 27 3 0.00308959835221421 971 10287 5577,5144,5567 PRKAR2B,PDE4D,PRKACB R-HSA-1482788 Acyl chain remodelling of PC 0.475624980025833 -0.743125592361807 27 3 0.00308959835221421 971 10287 5321,129642,54947 PLA2G4A,MBOAT2,LPCAT2 R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.475624980025833 -0.743125592361807 27 3 0.00308959835221421 971 10287 4088,56937,9372 SMAD3,PMEPA1,ZFYVE9 R-HSA-5610787 Hedgehog 'off' state 0.486233357184214 -0.721066611505745 101 10 0.0102986611740474 971 10287 27152,57728,107,112,5577,79659,23432,8945,5567,2735 INTU,WDR19,ADCY1,ADCY6,PRKAR2B,DYNC2H1,GPR161,BTRC,PRKACB,GLI1 R-HSA-937072 TRAF6 mediated induction of TAK1 complex 0.486372776173249 -0.720779919935112 17 2 0.00205973223480947 971 10287 7098,7099 TLR3,TLR4 R-HSA-140534 Ligand-dependent caspase activation 0.486372776173249 -0.720779919935112 17 2 0.00205973223480947 971 10287 7098,7099 TLR3,TLR4 R-HSA-435354 Zinc transporters 0.486372776173249 -0.720779919935112 17 2 0.00205973223480947 971 10287 23516,64116 SLC39A14,SLC39A8 R-HSA-189445 Metabolism of porphyrins 0.486372776173249 -0.720779919935112 17 2 0.00205973223480947 971 10287 7390,645 UROS,BLVRB R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.486372776173249 -0.720779919935112 17 2 0.00205973223480947 971 10287 3709,7222 ITPR2,TRPC3 R-HSA-1280215 Cytokine Signaling in Immune system 0.48681002640437 -0.719881321523004 756 72 0.0741503604531411 971 10287 685,23321,9462,1850,3600,2625,1147,3597,6777,3690,604,153090,4233,3556,10125,5159,9846,317649,5777,7431,8822,10538,958,2260,3669,8660,5903,3627,10718,3839,53840,2633,5924,7132,4128,9966,3082,7292,3977,4281,3636,60401,2335,9235,10673,51191,8809,4734,4609,2690,5580,10612,4684,8792,2674,6850,1052,1843,2264,54756,9693,1852,22821,1896,1435,5608,57161,2906,608,399473,3581,8945 BTC,TRIM2,RASAL2,DUSP8,IL15,GATA3,CHUK,IL13RA1,STAT5B,ITGB3,BCL6,DAB2IP,MET,IL1RAP,RASGRP1,PDGFRB,GAB2,EIF4E3,PTPN6,VIM,FGF17,BATF,CD40,FGFR1,ISG20,IRS2,RANBP2,CXCL10,NRG3,KPNA3,TRIM34,GBP1,RASGRF2,TNFRSF1A,MAOA,TNFSF15,HGF,TNFSF4,LIFR,MID1,INPPL1,EDA2R,FN1,IL32,TNFSF13B,HERC5,IL18R1,NEDD4,MYC,GHR,PRKCD,TRIM3,NCAM1,TNFRSF11A,GFRA1,SYK,CEBPD,DUSP1,FGFR4,IL17RD,RAPGEF2,DUSP9,RASA3,EDA,CSF1,MAP2K6,PELI2,GRIN2D,TNFRSF17,SPRED3,IL9R,BTRC R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.487913902769437 -0.717616317445526 59 6 0.00617919670442842 971 10287 170691,11174,9508,55901,79875,80731 ADAMTS17,ADAMTS6,ADAMTS3,THSD1,THSD4,THSD7B R-HSA-5655302 Signaling by FGFR1 in disease 0.488375034656487 -0.716671654644045 38 4 0.00411946446961895 971 10287 6777,8822,2260,9846 STAT5B,FGF17,FGFR1,GAB2 R-HSA-2980736 Peptide hormone metabolism 0.493481389885812 -0.706270131284072 91 9 0.00926879505664264 971 10287 3800,3626,590,56605,25924,1363,3798,4311,83729 KIF5C,INHBC,BCHE,ERO1B,MYRIP,CPE,KIF5A,MME,INHBE R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.496467934506665 -0.700236380650634 197 19 0.01956745623069 971 10287 2264,685,3164,5966,192670,1147,8822,2260,8660,57761,10718,5579,118788,10000,3082,4233,10125,8945,5159 FGFR4,BTC,NR4A1,REL,AGO4,CHUK,FGF17,FGFR1,IRS2,TRIB3,NRG3,PRKCB,PIK3AP1,AKT3,HGF,MET,RASGRP1,BTRC,PDGFRB R-HSA-190828 Gap junction trafficking 0.500413408299142 -0.692320705586211 28 3 0.00308959835221421 971 10287 4646,2706,10052 MYO6,GJB2,GJC1 R-HSA-6803529 FGFR2 alternative splicing 0.500413408299142 -0.692320705586211 28 3 0.00308959835221421 971 10287 23543,54845,2963 RBFOX2,ESRP1,GTF2F2 R-HSA-211976 Endogenous sterols 0.500413408299142 -0.692320705586211 28 3 0.00308959835221421 971 10287 1595,285440,1545 CYP51A1,CYP4V2,CYP1B1 R-HSA-174800 Chylomicron-mediated lipid transport 0.500413408299142 -0.692320705586211 28 3 0.00308959835221421 971 10287 3949,5046,5125 LDLR,PCSK6,PCSK5 R-HSA-1368082 RORA activates gene expression 0.500413408299142 -0.692320705586211 28 3 0.00308959835221421 971 10287 6604,10891,6720 SMARCD3,PPARGC1A,SREBF1 R-HSA-174577 Activation of C3 and C5 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 720 C4A R-HSA-447043 Neurofascin interactions 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 1272 CNTN1 R-HSA-3595177 Defective CHSY1 causes TPBS 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 63827 BCAN R-HSA-162791 Attachment of GPI anchor to uPAR 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 80055 PGAP1 R-HSA-426117 Cation-coupled Chloride cotransporters 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 9990 SLC12A6 R-HSA-190371 FGFR3b ligand binding and activation 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-429593 Inositol transporters 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 114134 SLC2A13 R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 63827 BCAN R-HSA-196843 Vitamin B2 (riboflavin) metabolism 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 5167 ENPP1 R-HSA-5603029 IkBA variant leads to EDA-ID 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-3595172 Defective CHST3 causes SEDCJD 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 63827 BCAN R-HSA-426496 Post-transcriptional silencing by small RNAs 0.500549177958607 -0.692049427394275 7 1 0.00102986611740474 971 10287 192670 AGO4 R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.509251069292364 -0.674814124137881 39 4 0.00411946446961895 971 10287 5627,2161,5547,2152 PROS1,F12,PRCP,F3 R-HSA-5628897 TP53 Regulates Metabolic Genes 0.515879434641214 -0.661882194597971 82 8 0.0082389289392379 971 10287 5563,192670,83667,27244,10000,2810,58528,54541 PRKAA2,AGO4,SESN2,SESN1,AKT3,SFN,RRAGD,DDIT4 R-HSA-6802949 Signaling by RAS mutants 0.515885131038656 -0.661871152548979 50 5 0.00514933058702369 971 10287 22821,153090,2335,9462,3690 RASA3,DAB2IP,FN1,RASAL2,ITGB3 R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.517402646073543 -0.658933895069448 18 2 0.00205973223480947 971 10287 6777,9846 STAT5B,GAB2 R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 0.517402646073543 -0.658933895069448 18 2 0.00205973223480947 971 10287 7098,7099 TLR3,TLR4 R-HSA-197264 Nicotinamide salvaging 0.517402646073543 -0.658933895069448 18 2 0.00205973223480947 971 10287 83594,83666 NUDT12,PARP9 R-HSA-196757 Metabolism of folate and pterines 0.517402646073543 -0.658933895069448 18 2 0.00205973223480947 971 10287 160428,10840 ALDH1L2,ALDH1L1 R-HSA-1369062 ABC transporters in lipid homeostasis 0.517402646073543 -0.658933895069448 18 2 0.00205973223480947 971 10287 23461,9619 ABCA5,ABCG1 R-HSA-442742 CREB phosphorylation through the activation of Ras 0.524589778911892 -0.64513869532306 29 3 0.00308959835221421 971 10287 2906,6196,5924 GRIN2D,RPS6KA2,RASGRF2 R-HSA-166054 Activated TLR4 signalling 0.528379208980265 -0.637941054230976 115 11 0.0113285272914521 971 10287 9261,6196,7098,57161,5608,1147,5602,7099,10333,8945,4208 MAPKAPK2,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,MAPK10,TLR4,TLR6,BTRC,MEF2C R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.53187704718736 -0.631342930660995 126 12 0.0123583934088568 971 10287 9261,26052,6196,7098,57161,5608,1147,5602,7099,10333,8945,4208 MAPKAPK2,DNM3,RPS6KA2,TLR3,PELI2,MAP2K6,CHUK,MAPK10,TLR4,TLR6,BTRC,MEF2C R-HSA-383280 Nuclear Receptor transcription pathway 0.533970540119811 -0.627414609858731 51 5 0.00514933058702369 971 10287 2649,3174,3164,4306,2104 NR6A1,HNF4G,NR4A1,NR3C2,ESRRG R-HSA-397795 G-protein beta:gamma signalling 0.533970540119811 -0.627414609858731 51 5 0.00514933058702369 971 10287 55970,23236,59345,10000,9846 GNG12,PLCB1,GNB4,AKT3,GAB2 R-HSA-1227986 Signaling by ERBB2 0.533970540119811 -0.627414609858731 51 5 0.00514933058702369 971 10287 685,10718,5578,10000,5580 BTC,NRG3,PRKCA,AKT3,PRKCD R-HSA-391251 Protein folding 0.537182069835662 -0.621418191964426 105 10 0.0102986611740474 971 10287 10382,11328,55970,7846,59345,2775,26272,402,6000,2770 TUBB4A,FKBP9,GNG12,TUBA1A,GNB4,GNAO1,FBXO4,ARL2,RGS7,GNAI1 R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.544090033334721 -0.608640543366683 84 8 0.0082389289392379 971 10287 9261,1147,6196,5602,57161,5608,8945,4208 MAPKAPK2,CHUK,RPS6KA2,MAPK10,PELI2,MAP2K6,BTRC,MEF2C R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.544090033334721 -0.608640543366683 84 8 0.0082389289392379 971 10287 9261,1147,6196,5602,57161,5608,8945,4208 MAPKAPK2,CHUK,RPS6KA2,MAPK10,PELI2,MAP2K6,BTRC,MEF2C R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.544090033334721 -0.608640543366683 84 8 0.0082389289392379 971 10287 9261,1147,6196,5602,57161,5608,8945,4208 MAPKAPK2,CHUK,RPS6KA2,MAPK10,PELI2,MAP2K6,BTRC,MEF2C R-HSA-5358351 Signaling by Hedgehog 0.546094839375716 -0.604962619830747 138 13 0.0133882595262616 971 10287 27152,57728,107,112,5577,147111,79659,85455,2619,23432,8945,5567,2735 INTU,WDR19,ADCY1,ADCY6,PRKAR2B,NOTUM,DYNC2H1,DISP2,GAS1,GPR161,BTRC,PRKACB,GLI1 R-HSA-5576886 Phase 4 - resting membrane potential 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 60598,3761 KCNK15,KCNJ4 R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 55970,59345 GNG12,GNB4 R-HSA-190861 Gap junction assembly 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 2706,10052 GJB2,GJC1 R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 2810,25946 SFN,ZNF385A R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 55117,6536 SLC6A15,SLC6A9 R-HSA-442982 Ras activation uopn Ca2+ infux through NMDA receptor 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 2906,5924 GRIN2D,RASGRF2 R-HSA-5223345 Miscellaneous transport and binding events 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 119,79815 ADD2,NIPAL2 R-HSA-8876725 Protein methylation 0.547157534977544 -0.603018519892863 19 2 0.00205973223480947 971 10287 1938,399818 EEF2,EEF1AKMT2 R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 50865 HEBP1 R-HSA-70921 Histidine catabolism 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 144193 AMDHD1 R-HSA-164944 Nef and signal transduction 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 1794 DOCK2 R-HSA-1253288 Downregulation of ERBB4 signaling 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 4734 NEDD4 R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 4233 MET R-HSA-1483115 Hydrolysis of LPC 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 5321 PLA2G4A R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 7424 VEGFC R-HSA-400451 Free fatty acids regulate insulin secretion 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 23236 PLCB1 R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 23236 PLCB1 R-HSA-77111 Synthesis of Ketone Bodies 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 56898 BDH2 R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 57491 AHRR R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-5358493 Synthesis of diphthamide-EEF2 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 1938 EEF2 R-HSA-194313 VEGF ligand-receptor interactions 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 7424 VEGFC R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 5563 PRKAA2 R-HSA-73942 DNA Damage Reversal 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 4255 MGMT R-HSA-5632681 Ligand-receptor interactions 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 2619 GAS1 R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 4825 NKX6-1 R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 5829 PXN R-HSA-1483148 Synthesis of PG 0.547724931648877 -0.601982067598812 8 1 0.00102986611740474 971 10287 5337 PLD1 R-HSA-8863795 Downregulation of ERBB2 signaling 0.548106586063266 -0.601285510831367 30 3 0.00308959835221421 971 10287 685,10718,10000 BTC,NRG3,AKT3 R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.549647721131109 -0.598477713002229 106 10 0.0102986611740474 971 10287 23516,30061,6536,5002,64116,11182,154091,55117,114134,55356 SLC39A14,SLC40A1,SLC6A9,SLC22A18,SLC39A8,SLC2A6,SLC2A12,SLC6A15,SLC2A13,SLC22A15 R-HSA-156580 Phase II conjugation 0.549647721131109 -0.598477713002229 106 10 0.0102986611740474 971 10287 26873,2946,119391,4259,2948,7358,2947,9446,79094,2098 OPLAH,GSTM2,GSTO2,MGST3,GSTM4,UGDH,GSTM3,GSTO1,CHAC1,ESD R-HSA-1226099 Signaling by FGFR in disease 0.553800789619968 -0.590950242424753 63 6 0.00617919670442842 971 10287 2264,6777,8822,2260,9846,2963 FGFR4,STAT5B,FGF17,FGFR1,GAB2,GTF2F2 R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.553800789619968 -0.590950242424753 63 6 0.00617919670442842 971 10287 6224,6206,6205,1978,6228,6207 RPS20,RPS12,RPS11,EIF4EBP1,RPS23,RPS13 R-HSA-4086400 PCP/CE pathway 0.559985452843253 -0.579844472655972 96 9 0.00926879505664264 971 10287 5579,8322,8325,144165,7481,4919,5578,5881,8321 PRKCB,FZD4,FZD8,PRICKLE1,WNT11,ROR1,PRKCA,RAC3,FZD1 R-HSA-6806667 Metabolism of fat-soluble vitamins 0.569179522375991 -0.563559389562593 53 5 0.00514933058702369 971 10287 9672,9227,10082,29967,3949 SDC3,LRAT,GPC6,LRP12,LDLR R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.569179522375991 -0.563559389562593 53 5 0.00514933058702369 971 10287 6224,6206,6205,6228,6207 RPS20,RPS12,RPS11,RPS23,RPS13 R-HSA-983189 Kinesins 0.569379536826957 -0.563208042917189 42 4 0.00411946446961895 971 10287 55605,23046,23095,3798 KIF21A,KIF21B,KIF1B,KIF5A R-HSA-5654733 Negative regulation of FGFR4 signaling 0.570925248750439 -0.560496990767349 31 3 0.00308959835221421 971 10287 2264,8822,10253 FGFR4,FGF17,SPRY2 R-HSA-2129379 Molecules associated with elastic fibres 0.570925248750439 -0.560496990767349 31 3 0.00308959835221421 971 10287 2202,652,3690 EFEMP1,BMP4,ITGB3 R-HSA-418990 Adherens junctions interactions 0.570925248750439 -0.560496990767349 31 3 0.00308959835221421 971 10287 253559,1000,1015 CADM2,CDH2,CDH17 R-HSA-5654687 Downstream signaling of activated FGFR1 0.570925248750439 -0.560496990767349 31 3 0.00308959835221421 971 10287 8822,23767,2260 FGF17,FLRT3,FGFR1 R-HSA-72766 Translation 0.571355576426152 -0.559743537349266 162 15 0.0154479917610711 971 10287 6224,6154,6136,1938,6158,6205,1978,6144,6124,6206,51121,23521,6228,6164,6207 RPS20,RPL26,RPL12,EEF2,RPL28,RPS11,EIF4EBP1,RPL21,RPL4,RPS12,RPL26L1,RPL13A,RPS23,RPL34,RPS13 R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.57560147910631 -0.552339734294828 20 2 0.00205973223480947 971 10287 9261,5608 MAPKAPK2,MAP2K6 R-HSA-5654720 PI-3K cascade:FGFR4 0.57560147910631 -0.552339734294828 20 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-5654719 SHC-mediated cascade:FGFR4 0.57560147910631 -0.552339734294828 20 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-8876384 Listeria monocytogenes entry into host cells 0.57560147910631 -0.552339734294828 20 2 0.00205973223480947 971 10287 4233,6456 MET,SH3GL2 R-HSA-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 0.57560147910631 -0.552339734294828 20 2 0.00205973223480947 971 10287 5567,2172 PRKACB,FABP6 R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.578765401217754 -0.546858062760379 443 41 0.0422245108135942 971 10287 685,55970,9170,2335,9462,1850,8477,3709,5028,5578,57406,6196,5580,3690,153090,4684,4233,2674,10125,1131,5159,1843,2264,54756,9693,1852,22821,5588,8822,23236,2260,747,8660,10718,5924,59345,2906,3082,5021,399473,7222 BTC,GNG12,LPAR2,FN1,RASAL2,DUSP8,GPR65,ITPR2,P2RY1,PRKCA,ABHD6,RPS6KA2,PRKCD,ITGB3,DAB2IP,NCAM1,MET,GFRA1,RASGRP1,CHRM3,PDGFRB,DUSP1,FGFR4,IL17RD,RAPGEF2,DUSP9,RASA3,PRKCQ,FGF17,PLCB1,FGFR1,DAGLA,IRS2,NRG3,RASGRF2,GNB4,GRIN2D,HGF,OXTR,SPRED3,TRPC3 R-HSA-211945 Phase 1 - Functionalization of compounds 0.58623246068893 -0.534038877470593 109 10 0.0102986611740474 971 10287 1595,57491,217,1573,285440,4128,113612,1592,1545,23491 CYP51A1,AHRR,ALDH2,CYP2J2,CYP4V2,MAOA,CYP2U1,CYP26A1,CYP1B1,CES3 R-HSA-75893 TNF signaling 0.588489042393422 -0.530196972007535 43 4 0.00411946446961895 971 10287 1147,10399,9099,7132 CHUK,RACK1,USP2,TNFRSF1A R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.588489042393422 -0.530196972007535 43 4 0.00411946446961895 971 10287 25776,83439,26108,8945 CBY1,TCF7L1,PYGO1,BTRC R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 85415 RHPN2 R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 81894 SLC25A28 R-HSA-419771 Opsins 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 23596 OPN3 R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 760 CA2 R-HSA-425986 Sodium/Proton exchangers 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 84679 SLC9A7 R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 192670 AGO4 R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 241 ALOX5AP R-HSA-74182 Ketone body metabolism 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 56898 BDH2 R-HSA-2179392 EGFR Transactivation by Gastrin 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 5578 PRKCA R-HSA-390696 Adrenoceptors 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 153 ADRB1 R-HSA-1614558 Degradation of cysteine and homocysteine 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 1491 CTH R-HSA-2428933 SHC-related events triggered by IGF1R 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 3480 IGF1R R-HSA-163765 ChREBP activates metabolic gene expression 0.590448843658243 -0.526872279344347 9 1 0.00102986611740474 971 10287 2194 FASN R-HSA-168638 NOD1/2 Signaling Pathway 0.59301536894935 -0.522534963036363 32 3 0.00308959835221421 971 10287 5603,1147,5608 MAPK13,CHUK,MAP2K6 R-HSA-390466 Chaperonin-mediated protein folding 0.598096817700486 -0.514002635627128 99 9 0.00926879505664264 971 10287 10382,11328,55970,7846,59345,2775,26272,6000,2770 TUBB4A,FKBP9,GNG12,TUBA1A,GNB4,GNAO1,FBXO4,RGS7,GNAI1 R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling 0.598096817700486 -0.514002635627128 99 9 0.00926879505664264 971 10287 9261,6196,7098,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-166166 MyD88-independent TLR3/TLR4 cascade 0.598096817700486 -0.514002635627128 99 9 0.00926879505664264 971 10287 9261,6196,7098,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.598096817700486 -0.514002635627128 99 9 0.00926879505664264 971 10287 9261,6196,7098,5608,1147,7099,5602,8945,4208 MAPKAPK2,RPS6KA2,TLR3,MAP2K6,CHUK,TLR4,MAPK10,BTRC,MEF2C R-HSA-8856688 Golgi-to-ER retrograde transport 0.598127259935133 -0.513951738416108 110 10 0.0102986611740474 971 10287 5321,2589,662,51560,3798,54732,55605,23046,1780,23095 PLA2G4A,GALNT1,BNIP1,RAB6B,KIF5A,TMED9,KIF21A,KIF21B,DYNC1I1,KIF1B R-HSA-446728 Cell junction organization 0.598386467625334 -0.513518466840053 88 8 0.0082389289392379 971 10287 5829,9069,3655,1015,10979,253559,1000,10207 PXN,CLDN12,ITGA6,CDH17,FERMT2,CADM2,CDH2,PATJ R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.599128334610465 -0.512279455716929 77 7 0.00720906282183316 971 10287 4088,57530,56937,4609,9372,25937,6497 SMAD3,CGN,PMEPA1,MYC,ZFYVE9,WWTR1,SKI R-HSA-5654688 SHC-mediated cascade:FGFR1 0.60271664034563 -0.506308109208391 21 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 0.60271664034563 -0.506308109208391 21 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.60271664034563 -0.506308109208391 21 2 0.00205973223480947 971 10287 1147,7098 CHUK,TLR3 R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.60271664034563 -0.506308109208391 21 2 0.00205973223480947 971 10287 3489,3486 IGFBP6,IGFBP3 R-HSA-109606 Intrinsic Pathway for Apoptosis 0.607092595635586 -0.499073953204779 44 4 0.00411946446961895 971 10287 27113,5366,10000,2810 BBC3,PMAIP1,AKT3,SFN R-HSA-917937 Iron uptake and transport 0.607092595635586 -0.499073953204779 44 4 0.00411946446961895 971 10287 90423,55240,30061,51310 ATP6V1E2,STEAP3,SLC40A1,SLC22A17 R-HSA-6785807 Interleukin-4 and 13 signaling 0.609858694433239 -0.494527997119531 111 10 0.0102986611740474 971 10287 2335,4609,604,2625,4128,3082,3597,7431,10538,1052 FN1,MYC,BCL6,GATA3,MAOA,HGF,IL13RA1,VIM,BATF,CEBPD R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 0.613052615587021 -0.489304513797842 78 7 0.00720906282183316 971 10287 440138,256435,6489,4597,6480,79644,144245 ALG11,ST6GALNAC3,ST8SIA1,MVD,ST6GAL1,SRD5A3,ALG10B R-HSA-186712 Regulation of beta-cell development 0.614354001432618 -0.487183967411314 33 3 0.00308959835221421 971 10287 4825,3174,10000 NKX6-1,HNF4G,AKT3 R-HSA-4085001 Sialic acid metabolism 0.614354001432618 -0.487183967411314 33 3 0.00308959835221421 971 10287 256435,6489,6480 ST6GALNAC3,ST8SIA1,ST6GAL1 R-HSA-5654726 Negative regulation of FGFR1 signaling 0.614354001432618 -0.487183967411314 33 3 0.00308959835221421 971 10287 8822,10253,2260 FGF17,SPRY2,FGFR1 R-HSA-389356 CD28 co-stimulation 0.614354001432618 -0.487183967411314 33 3 0.00308959835221421 971 10287 5058,57761,10000 PAK1,TRIB3,AKT3 R-HSA-1643685 Disease 0.618768106748244 -0.480024702095897 859 79 0.0813594232749743 971 10287 685,9462,5611,4869,1147,11174,6777,1488,821,63827,1794,83999,9372,9715,7098,3690,153090,4233,51121,7099,55901,57670,5159,9846,6207,118429,8322,79875,8822,10082,2260,4088,8660,5903,10718,3839,10827,3082,92421,23462,6224,9899,2335,54845,8325,3843,23521,6164,80853,1938,118788,6205,4609,2963,4040,6228,2264,6154,3164,6144,9672,22821,6616,6875,10333,22943,170691,6136,155382,6158,6456,9508,5608,10000,26508,80731,6206,6124,8945 BTC,RASAL2,DNAJC3,NPM1,CHUK,ADAMTS6,STAT5B,CTBP2,CANX,BCAN,DOCK2,KREMEN1,ZFYVE9,FAM131B,TLR3,ITGB3,DAB2IP,MET,RPL26L1,TLR4,THSD1,KIAA1549,PDGFRB,GAB2,RPS13,ANTXR2,FZD4,THSD4,FGF17,GPC6,FGFR1,SMAD3,IRS2,RANBP2,NRG3,KPNA3,FAM114A2,HGF,CHMP4C,HEY1,RPS20,SV2B,FN1,ESRP1,FZD8,IPO5,RPL13A,RPL34,KDM7A,EEF2,PIK3AP1,RPS11,MYC,GTF2F2,LRP6,RPS23,FGFR4,RPL26,NR4A1,RPL21,SDC3,RASA3,SNAP25,TAF4B,TLR6,DKK1,ADAMTS17,RPL12,VPS37D,RPL28,SH3GL2,ADAMTS3,MAP2K6,AKT3,HEYL,THSD7B,RPS12,RPL4,BTRC R-HSA-211859 Biological oxidations 0.621895077762582 -0.474983885741079 222 20 0.0205973223480947 971 10287 26873,2946,217,1573,4259,2948,7358,285440,9446,79094,1592,57491,1595,119391,2947,4128,113612,2098,1545,23491 OPLAH,GSTM2,ALDH2,CYP2J2,MGST3,GSTM4,UGDH,CYP4V2,GSTO1,CHAC1,CYP26A1,AHRR,CYP51A1,GSTO2,GSTM3,MAOA,CYP2U1,ESD,CYP1B1,CES3 R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 5788,5795 PTPRC,PTPRJ R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 2161,5547 F12,PRCP R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 57761,10000 TRIB3,AKT3 R-HSA-5621575 CD209 (DC-SIGN) signaling 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 5058,5567 PAK1,PRKACB R-HSA-166208 mTORC1-mediated signalling 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 1978,58528 EIF4EBP1,RRAGD R-HSA-5654712 FRS-mediated FGFR4 signaling 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-1482801 Acyl chain remodelling of PS 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 5321,114879 PLA2G4A,OSBPL5 R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 9261,241 MAPKAPK2,ALOX5AP R-HSA-198753 ERK/MAPK targets 0.628500211036845 -0.464418915173299 22 2 0.00205973223480947 971 10287 6196,4208 RPS6KA2,MEF2C R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 134353 LSM11 R-HSA-74259 Purine catabolism 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 4860 PNP R-HSA-196108 Pregnenolone biosynthesis 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 134429 STARD4 R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 9896 FIG4 R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 9486 CHST10 R-HSA-70635 Urea cycle 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 445 ASS1 R-HSA-450341 Activation of the AP-1 family of transcription factors 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 5602 MAPK10 R-HSA-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 6296 ACSM3 R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 5608 MAP2K6 R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 27113 BBC3 R-HSA-190873 Gap junction degradation 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 4646 MYO6 R-HSA-2161522 Abacavir transport and metabolism 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 161823 ADAL R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.629140629301693 -0.463400471274753 10 1 0.00102986611740474 971 10287 170685 NUDT10 R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.630171388709113 -0.461763451024224 68 6 0.00617919670442842 971 10287 1595,113612,1573,1592,285440,1545 CYP51A1,CYP2U1,CYP2J2,CYP26A1,CYP4V2,CYP1B1 R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.634924944175469 -0.454248485224266 34 3 0.00308959835221421 971 10287 4088,4609,25937 SMAD3,MYC,WWTR1 R-HSA-5694530 Cargo concentration in the ER 0.634924944175469 -0.454248485224266 34 3 0.00308959835221421 971 10287 10960,9871,7039 LMAN2,SEC24D,TGFA R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.634924944175469 -0.454248485224266 34 3 0.00308959835221421 971 10287 4088,56937,9372 SMAD3,PMEPA1,ZFYVE9 R-HSA-1483166 Synthesis of PA 0.634924944175469 -0.454248485224266 34 3 0.00308959835221421 971 10287 5321,5337,56895 PLA2G4A,PLD1,AGPAT4 R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.642715056519984 -0.442053799899401 46 4 0.00411946446961895 971 10287 4088,4609,25937,6497 SMAD3,MYC,WWTR1,SKI R-HSA-70153 Glucose transport 0.642715056519984 -0.442053799899401 46 4 0.00411946446961895 971 10287 5903,3098,85414,3099 RANBP2,HK1,SLC45A3,HK2 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.649267140332333 -0.431911028583934 92 8 0.0082389289392379 971 10287 8875,152330,8434,51299,22854,80055,257194,2822 VNN2,CNTN4,RECK,NRN1,NTNG1,PGAP1,NEGR1,GPLD1 R-HSA-381070 IRE1alpha activates chaperones 0.65068311927201 -0.42973251523048 58 5 0.00514933058702369 971 10287 55033,5611,7466,7494,2081 FKBP14,DNAJC3,WFS1,XBP1,ERN1 R-HSA-5205685 Pink/Parkin Mediated Mitophagy 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 5071,9474 PRKN,ATG5 R-HSA-5627123 RHO GTPases activate PAKs 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 5058,2017 PAK1,CTTN R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 4088,6497 SMAD3,SKI R-HSA-428930 Thromboxane signalling through TP receptor 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 55970,59345 GNG12,GNB4 R-HSA-5654693 FRS-mediated FGFR1 signaling 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 8822,2260 FGF17,FGFR1 R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 9227,285440 LRAT,CYP4V2 R-HSA-5205647 Mitophagy 0.652961740556223 -0.426236741688304 23 2 0.00205973223480947 971 10287 5071,9474 PRKN,ATG5 R-HSA-195721 Signaling by Wnt 0.655495799502181 -0.422363383881018 336 30 0.0308959835221421 971 10287 55970,55366,8322,79971,8325,144165,192670,1488,25776,7481,3709,4919,26108,5578,23236,5881,83999,22943,83439,7015,5579,51339,4609,2775,59345,5592,4040,5593,8945,8321 GNG12,LGR4,FZD4,WLS,FZD8,PRICKLE1,AGO4,CTBP2,CBY1,WNT11,ITPR2,ROR1,PYGO1,PRKCA,PLCB1,RAC3,KREMEN1,DKK1,TCF7L1,TERT,PRKCB,DACT1,MYC,GNAO1,GNB4,PRKG1,LRP6,PRKG2,BTRC,FZD1 R-HSA-5625970 RHO GTPases activate KTN1 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 3798 KIF5A R-HSA-71288 Creatine metabolism 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 2628 GATM R-HSA-73614 Pyrimidine salvage reactions 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 1890 TYMP R-HSA-174490 Membrane binding and targetting of GAG proteins 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 155382 VPS37D R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 5563 PRKAA2 R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 155382 VPS37D R-HSA-446107 Type I hemidesmosome assembly 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 3655 ITGA6 R-HSA-193048 Androgen biosynthesis 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 79644 SRD5A3 R-HSA-5655291 Signaling by FGFR4 in disease 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 2264 FGFR4 R-HSA-189451 Heme biosynthesis 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 7390 UROS R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.66418047058992 -0.409201373377636 11 1 0.00102986611740474 971 10287 134353 LSM11 R-HSA-400253 Circadian Clock 0.672129209177002 -0.397304681380549 71 6 0.00617919670442842 971 10287 6604,1628,10891,8945,6720,4208 SMARCD3,DBP,PPARGC1A,BTRC,SREBF1,MEF2C R-HSA-877300 Interferon gamma signaling 0.673261000722294 -0.3956222076953 94 8 0.0082389289392379 971 10287 10612,23321,4684,53840,2633,4281,5777,5580 TRIM3,TRIM2,NCAM1,TRIM34,GBP1,MID1,PTPN6,PRKCD R-HSA-936440 Negative regulators of RIG-I/MDA5 signaling 0.673728608159104 -0.394927907676189 36 3 0.00308959835221421 971 10287 54941,51191,9474 RNF125,HERC5,ATG5 R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.676148219471968 -0.391342967399123 48 4 0.00411946446961895 971 10287 55970,59345,10000,9846 GNG12,GNB4,AKT3,GAB2 R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 0.676148219471968 -0.391342967399123 48 4 0.00411946446961895 971 10287 10910,5603,1147,5608 SUGT1,MAPK13,CHUK,MAP2K6 R-HSA-168249 Innate Immune System 0.684692645967465 -0.378785233430595 1285 117 0.120494335736354 971 10287 84443,685,26052,5153,9522,9462,1850,3075,1793,720,10396,5611,8673,1147,3709,10584,3937,5578,1794,963,81567,7098,6196,230,3690,153090,5627,4233,7099,10125,5567,5159,9846,25801,1604,5777,475,4033,107,54941,192670,5577,5588,23406,8822,2444,1832,725,2260,8660,2934,10718,5795,10855,3071,644150,5924,226,5603,3082,9474,5602,4208,10810,2335,3958,90423,6402,51191,1938,118788,5580,112,4684,353189,178,6850,2674,10970,1843,4846,2264,5058,54756,5768,10451,4860,11001,4651,3164,9693,1852,22821,715,10577,6616,23250,10333,10458,9261,5788,57761,10910,2268,5547,57161,10000,5608,1515,11031,5799,2906,5337,399473,8945,4311,2040 FRMPD3,BTC,DNM3,PDE1B,SCAMP1,RASAL2,DUSP8,CFH,DOCK1,C4A,ATP8A1,DNAJC3,VAMP8,CHUK,ITPR2,COLEC10,LCP2,PRKCA,DOCK2,CD53,TXNDC5,TLR3,RPS6KA2,ALDOC,ITGB3,DAB2IP,PROS1,MET,TLR4,RASGRP1,PRKACB,PDGFRB,GAB2,GCA,CD55,PTPN6,ATOX1,LRMP,ADCY1,RNF125,AGO4,PRKAR2B,PRKCQ,COTL1,FGF17,FRK,DSP,C4BPB,FGFR1,IRS2,GSN,NRG3,PTPRJ,HPSE,NCKAP1L,WIPF3,RASGRF2,ALDOA,MAPK13,HGF,ATG5,MAPK10,MEF2C,WASF3,FN1,LGALS3,ATP6V1E2,SELL,HERC5,EEF2,PIK3AP1,PRKCD,ADCY6,NCAM1,SLCO4C1,AGL,SYK,GFRA1,CKAP4,DUSP1,NOS3,FGFR4,PAK1,IL17RD,QSOX1,VAV3,PNP,SLC27A2,MYO10,NR4A1,RAPGEF2,DUSP9,RASA3,C1R,NPC2,SNAP25,ATP11A,TLR6,BAIAP2,MAPKAPK2,PTPRC,TRIB3,SUGT1,FGR,PRCP,PELI2,AKT3,MAP2K6,CTSV,RAB31,PTPRN2,GRIN2D,PLD1,SPRED3,BTRC,MME,STOM R-HSA-2682334 EPH-Ephrin signaling 0.68487545545077 -0.37851827411079 95 8 0.0082389289392379 971 10287 2042,1948,5058,10451,64283,1944,2051,2047 EPHA3,EFNB2,PAK1,VAV3,ARHGEF28,EFNA3,EPHB6,EPHB1 R-HSA-948021 Transport to the Golgi and subsequent modification 0.693967271371806 -0.365330478993991 164 14 0.0144181256436663 971 10287 1604,89866,9871,4245,7039,6480,287,11282,54732,10960,83548,1780,9486,9331 CD55,SEC16B,SEC24D,MGAT1,TGFA,ST6GAL1,ANK2,MGAT4B,TMED9,LMAN2,COG3,DYNC1I1,CHST10,B4GALT6 R-HSA-421270 Cell-cell junction organization 0.694599168439725 -0.364420335851508 61 5 0.00514933058702369 971 10287 253559,1000,9069,10207,1015 CADM2,CDH2,CLDN12,PATJ,CDH17 R-HSA-72702 Ribosomal scanning and start codon recognition 0.694599168439725 -0.364420335851508 61 5 0.00514933058702369 971 10287 6224,6206,6205,6228,6207 RPS20,RPS12,RPS11,RPS23,RPS13 R-HSA-1839130 Signaling by activated point mutants of FGFR3 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 2810 SFN R-HSA-8851680 Butyrophilin (BTN) family interactions 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 153579 BTNL9 R-HSA-5578768 Physiological factors 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 25937 WWTR1 R-HSA-390666 Serotonin receptors 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 3363 HTR7 R-HSA-73621 Pyrimidine catabolism 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 1890 TYMP R-HSA-71384 Ethanol oxidation 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 217 ALDH2 R-HSA-211958 Miscellaneous substrates 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 113612 CYP2U1 R-HSA-8866427 VLDLR internalisation and degradation 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 7436 VLDLR R-HSA-417957 P2Y receptors 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 5028 P2RY1 R-HSA-2033514 FGFR3 mutant receptor activation 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-166786 Creation of C4 and C2 activators 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 715 C1R R-HSA-1236977 Endosomal/Vacuolar pathway 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 1515 CTSV R-HSA-844456 The NLRP3 inflammasome 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 10910 SUGT1 R-HSA-5689877 Josephin domain DUBs 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 5071 PRKN R-HSA-389359 CD28 dependent Vav1 pathway 0.695912736368443 -0.362531005289266 12 1 0.00102986611740474 971 10287 5058 PAK1 R-HSA-168898 Toll-Like Receptors Cascades 0.696480211356671 -0.361715897714104 153 13 0.0133882595262616 971 10287 9261,26052,6196,7098,57161,5608,1515,1147,5602,7099,10333,8945,4208 MAPKAPK2,DNM3,RPS6KA2,TLR3,PELI2,MAP2K6,CTSV,CHUK,MAPK10,TLR4,TLR6,BTRC,MEF2C R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 55970,3761 GNG12,KCNJ4 R-HSA-1614635 Sulfur amino acid metabolism 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 875,1491 CBS,CTH R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 821,9871 CANX,SEC24D R-HSA-182971 EGFR downregulation 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 6456,10253 SH3GL2,SPRY2 R-HSA-977068 Termination of O-glycan biosynthesis 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 256435,6480 ST6GALNAC3,ST6GAL1 R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 1147,7098 CHUK,TLR3 R-HSA-1296059 G protein gated Potassium channels 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 55970,3761 GNG12,KCNJ4 R-HSA-162588 Budding and maturation of HIV virion 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 155382,92421 VPS37D,CHMP4C R-HSA-499943 Synthesis and interconversion of nucleotide di- and triphosphates 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 205,203 AK4,AK1 R-HSA-1296041 Activation of G protein gated Potassium channels 0.698005162086912 -0.359528780707123 25 2 0.00205973223480947 971 10287 55970,3761 GNG12,KCNJ4 R-HSA-5654736 Signaling by FGFR1 0.70734359294831 -0.346238743942052 50 4 0.00411946446961895 971 10287 8822,10253,23767,2260 FGF17,SPRY2,FLRT3,FGFR1 R-HSA-73887 Death Receptor Signalling 0.70734359294831 -0.346238743942052 50 4 0.00411946446961895 971 10287 1147,10399,9099,7132 CHUK,RACK1,USP2,TNFRSF1A R-HSA-72649 Translation initiation complex formation 0.708364444530346 -0.344796565566359 62 5 0.00514933058702369 971 10287 6224,6206,6205,6228,6207 RPS20,RPS12,RPS11,RPS23,RPS13 R-HSA-3238698 WNT ligand biogenesis and trafficking 0.718648786716015 -0.330382515268497 26 2 0.00205973223480947 971 10287 7481,79971 WNT11,WLS R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.718648786716015 -0.330382515268497 26 2 0.00205973223480947 971 10287 10382,7846 TUBB4A,TUBA1A R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.721688897531535 -0.326161122794535 63 5 0.00514933058702369 971 10287 256435,6489,4597,6480,79644 ST6GALNAC3,ST8SIA1,MVD,ST6GAL1,SRD5A3 R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 7020 TFAP2A R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 3958 LGALS3 R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-2168880 Scavenging of heme from plasma 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 3512 JCHAIN R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 2649 NR6A1 R-HSA-375281 Hormone ligand-binding receptors 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 7253 TSHR R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 4919 ROR1 R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 10000 AKT3 R-HSA-5626467 RHO GTPases activate IQGAPs 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 128239 IQGAP3 R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-2408517 SeMet incorporation into proteins 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 4141 MARS R-HSA-75892 Platelet Adhesion to exposed collagen 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 3673 ITGA2 R-HSA-190375 FGFR2c ligand binding and activation 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 3709 ITPR2 R-HSA-175474 Assembly Of The HIV Virion 0.724649352708342 -0.322067392561314 13 1 0.00102986611740474 971 10287 155382 VPS37D R-HSA-5674135 MAP2K and MAPK activation 0.726086142321349 -0.320086617860899 39 3 0.00308959835221421 971 10287 54756,2335,3690 IL17RD,FN1,ITGB3 R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 0.726086142321349 -0.320086617860899 39 3 0.00308959835221421 971 10287 5627,2621,1938 PROS1,GAS6,EEF2 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.728694160474339 -0.316501167959063 99 8 0.0082389289392379 971 10287 6456,115548,8322,85439,157,3949,8673,9856 SH3GL2,FCHO2,FZD4,STON2,GRK3,LDLR,VAMP8,KIAA0319 R-HSA-2980766 Nuclear Envelope Breakdown 0.736295049820076 -0.306124357677634 52 4 0.00411946446961895 971 10287 5903,64900,5578,5579 RANBP2,LPIN3,PRKCA,PRKCB R-HSA-5654716 Downstream signaling of activated FGFR4 0.738090691249512 -0.303688574059793 27 2 0.00205973223480947 971 10287 2264,8822 FGFR4,FGF17 R-HSA-901042 Calnexin/calreticulin cycle 0.738090691249512 -0.303688574059793 27 2 0.00205973223480947 971 10287 821,80267 CANX,EDEM3 R-HSA-400685 Sema4D in semaphorin signaling 0.738090691249512 -0.303688574059793 27 2 0.00205973223480947 971 10287 4233,9826 MET,ARHGEF11 R-HSA-5675221 Negative regulation of MAPK pathway 0.742006686965475 -0.298397023772515 40 3 0.00308959835221421 971 10287 1852,1850,1843 DUSP9,DUSP8,DUSP1 R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.742006686965475 -0.298397023772515 40 3 0.00308959835221421 971 10287 353189,28232,6567 SLCO4C1,SLCO3A1,SLC16A2 R-HSA-5654741 Signaling by FGFR3 0.742006686965475 -0.298397023772515 40 3 0.00308959835221421 971 10287 2591,8822,10253 GALNT3,FGF17,SPRY2 R-HSA-2187338 Visual phototransduction 0.748988632123206 -0.289031472985695 101 8 0.0082389289392379 971 10287 3949,285440,9672,5588,5578,9227,29967,10082 LDLR,CYP4V2,SDC3,PRKCQ,PRKCA,LRAT,LRP12,GPC6 R-HSA-2024101 CS/DS degradation 0.750672856555805 -0.286785332568794 14 1 0.00102986611740474 971 10287 63827 BCAN R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.750672856555805 -0.286785332568794 14 1 0.00102986611740474 971 10287 11001 SLC27A2 R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.750672856555805 -0.286785332568794 14 1 0.00102986611740474 971 10287 5163 PDK1 R-HSA-877312 Regulation of IFNG signaling 0.750672856555805 -0.286785332568794 14 1 0.00102986611740474 971 10287 5777 PTPN6 R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.75637355916324 -0.279219898965294 28 2 0.00205973223480947 971 10287 155382,92421 VPS37D,CHMP4C R-HSA-1266695 Interleukin-7 signaling 0.75637355916324 -0.279219898965294 28 2 0.00205973223480947 971 10287 6777,3082 STAT5B,HGF R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.75637355916324 -0.279219898965294 28 2 0.00205973223480947 971 10287 3636,23236 INPPL1,PLCB1 R-HSA-5654743 Signaling by FGFR4 0.757182038272771 -0.278151581174003 41 3 0.00308959835221421 971 10287 2264,8822,10253 FGFR4,FGF17,SPRY2 R-HSA-6798695 Neutrophil degranulation 0.757984643549388 -0.277092152714659 487 42 0.043254376930999 971 10287 84443,3958,9522,10396,5611,8673,6402,1794,963,81567,1938,230,5580,353189,178,10970,5768,25801,1604,4860,11001,5777,4033,23250,6616,10577,23406,2444,1832,5788,2934,2268,5795,10855,3071,5547,226,11031,5799,5337,4311,2040 FRMPD3,LGALS3,SCAMP1,ATP8A1,DNAJC3,VAMP8,SELL,DOCK2,CD53,TXNDC5,EEF2,ALDOC,PRKCD,SLCO4C1,AGL,CKAP4,QSOX1,GCA,CD55,PNP,SLC27A2,PTPN6,LRMP,ATP11A,SNAP25,NPC2,COTL1,FRK,DSP,PTPRC,GSN,FGR,PTPRJ,HPSE,NCKAP1L,PRCP,ALDOA,RAB31,PTPRN2,PLD1,MME,STOM R-HSA-189200 Hexose transport 0.763031374727867 -0.270456128323084 54 4 0.00411946446961895 971 10287 5903,3098,85414,3099 RANBP2,HK1,SLC45A3,HK2 R-HSA-1592230 Mitochondrial biogenesis 0.763031374727867 -0.270456128323084 54 4 0.00411946446961895 971 10287 5563,6604,10891,4208 PRKAA2,SMARCD3,PPARGC1A,MEF2C R-HSA-168256 Immune System 0.768625127693013 -0.263151908576771 2101 190 0.1956745623069 971 10287 23321,5153,1850,3798,10396,5611,8673,2625,10859,55740,6777,3709,5578,143279,81567,114907,6196,3690,7220,7099,3556,10125,5567,5159,3695,1604,317649,26249,475,4033,192670,5577,23406,8822,10538,114088,2934,10855,3071,644150,57630,5924,226,7132,5603,7292,4208,91694,3636,9902,3958,2335,9871,26272,90423,55008,1780,8809,1938,118788,4609,8139,5592,112,4684,353189,178,2674,10970,1052,4846,2264,5058,54756,5768,4860,153579,4651,11001,11069,1852,715,10577,6616,10458,9261,6456,57161,1435,374383,11031,5799,5337,399473,126433,4311,84443,5071,685,26052,3075,9462,9522,3600,1793,720,57520,3597,1147,10584,821,3937,1794,963,7098,230,604,153090,64219,5627,4233,9846,25801,51466,5777,107,54941,5588,7431,958,2444,1832,725,2260,3669,8660,5903,3627,10718,5795,154214,53840,3839,5579,2633,4128,9966,3082,55819,9474,5602,3977,4281,57531,10810,9235,60401,90293,5966,10673,6402,51191,4734,2690,5580,10612,8792,6850,80329,1843,10451,3164,9693,22821,23250,10333,5788,57761,10910,2268,1896,5547,10000,5608,1515,2906,608,3581,8945,2040 TRIM2,PDE1B,DUSP8,KIF5A,ATP8A1,DNAJC3,VAMP8,GATA3,LILRB1,ENAH,STAT5B,ITPR2,PRKCA,HECTD2,TXNDC5,FBXO32,RPS6KA2,ITGB3,TRPC1,TLR4,IL1RAP,RASGRP1,PRKACB,PDGFRB,ITGB7,CD55,EIF4E3,KLHL3,ATOX1,LRMP,AGO4,PRKAR2B,COTL1,FGF17,BATF,TRIM9,GSN,HPSE,NCKAP1L,WIPF3,SH3RF1,RASGRF2,ALDOA,TNFRSF1A,MAPK13,TNFSF4,MEF2C,LONRF1,INPPL1,MRC2,LGALS3,FN1,SEC24D,FBXO4,ATP6V1E2,HERC6,DYNC1I1,IL18R1,EEF2,PIK3AP1,MYC,GAN,PRKG1,ADCY6,NCAM1,SLCO4C1,AGL,GFRA1,CKAP4,CEBPD,NOS3,FGFR4,PAK1,IL17RD,QSOX1,PNP,BTNL9,MYO10,SLC27A2,RAPGEF4,DUSP9,C1R,NPC2,SNAP25,BAIAP2,MAPKAPK2,SH3GL2,PELI2,CSF1,NCR3LG1,RAB31,PTPRN2,PLD1,SPRED3,FBXO27,MME,FRMPD3,PRKN,BTC,DNM3,CFH,RASAL2,SCAMP1,IL15,DOCK1,C4A,HECW2,IL13RA1,CHUK,COLEC10,CANX,LCP2,DOCK2,CD53,TLR3,ALDOC,BCL6,DAB2IP,PJA1,PROS1,MET,GAB2,GCA,EVL,PTPN6,ADCY1,RNF125,PRKCQ,VIM,CD40,FRK,DSP,C4BPB,FGFR1,ISG20,IRS2,RANBP2,CXCL10,NRG3,PTPRJ,RNF217,TRIM34,KPNA3,PRKCB,GBP1,MAOA,TNFSF15,HGF,RNF130,ATG5,MAPK10,LIFR,MID1,HACE1,WASF3,IL32,EDA2R,KLHL13,REL,TNFSF13B,SELL,HERC5,NEDD4,GHR,PRKCD,TRIM3,TNFRSF11A,SYK,ULBP1,DUSP1,VAV3,NR4A1,RAPGEF2,RASA3,ATP11A,TLR6,PTPRC,TRIB3,SUGT1,FGR,EDA,PRCP,AKT3,MAP2K6,CTSV,GRIN2D,TNFRSF17,IL9R,BTRC,STOM R-HSA-1632852 Macroautophagy 0.770596429600124 -0.260590480073427 67 5 0.00514933058702369 971 10287 5563,9474,92421,58528,23710 PRKAA2,ATG5,CHMP4C,RRAGD,GABARAPL1 R-HSA-3700989 Transcriptional Regulation by TP53 0.77128057953904 -0.259703055227269 367 31 0.0319258496395469 971 10287 5563,9099,83667,665,4869,192670,639,900,8794,6875,85456,27244,54541,5325,5366,57060,10000,10769,5608,8900,27166,2963,604,6446,27113,55240,2810,64065,25946,3486,58528 PRKAA2,USP2,SESN2,BNIP3L,NPM1,AGO4,PRDM1,CCNG1,TNFRSF10C,TAF4B,TNKS1BP1,SESN1,DDIT4,PLAGL1,PMAIP1,PCBP4,AKT3,PLK2,MAP2K6,CCNA1,PRELID1,GTF2F2,BCL6,SGK1,BBC3,STEAP3,SFN,PERP,ZNF385A,IGFBP3,RRAGD R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.773542728060448 -0.25677437059753 29 2 0.00205973223480947 971 10287 10382,7846 TUBB4A,TUBA1A R-HSA-5654732 Negative regulation of FGFR3 signaling 0.773542728060448 -0.25677437059753 29 2 0.00205973223480947 971 10287 8822,10253 FGF17,SPRY2 R-HSA-390918 Peroxisomal lipid metabolism 0.773542728060448 -0.25677437059753 29 2 0.00205973223480947 971 10287 1962,11001 EHHADH,SLC27A2 R-HSA-156581 Methylation 0.774239162053107 -0.255874458220847 15 1 0.00102986611740474 971 10287 9446 GSTO1 R-HSA-3371568 Attenuation phase 0.774239162053107 -0.255874458220847 15 1 0.00102986611740474 971 10287 3306 HSPA2 R-HSA-211935 Fatty acids 0.774239162053107 -0.255874458220847 15 1 0.00102986611740474 971 10287 1573 CYP2J2 R-HSA-375280 Amine ligand-binding receptors 0.785363835196856 -0.241608184248208 43 3 0.00308959835221421 971 10287 3363,1131,153 HTR7,CHRM3,ADRB1 R-HSA-194068 Bile acid and bile salt metabolism 0.785363835196856 -0.241608184248208 43 3 0.00308959835221421 971 10287 11001,114880,2172 SLC27A2,OSBPL6,FABP6 R-HSA-381038 XBP1(S) activates chaperone genes 0.78760937774421 -0.238753025553401 56 4 0.00411946446961895 971 10287 55033,5611,7466,7494 FKBP14,DNAJC3,WFS1,XBP1 R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.789645309635468 -0.236171409485566 30 2 0.00205973223480947 971 10287 92737,1272 DNER,CNTN1 R-HSA-420092 Glucagon-type ligand receptors 0.789645309635468 -0.236171409485566 30 2 0.00205973223480947 971 10287 55970,59345 GNG12,GNB4 R-HSA-917977 Transferrin endocytosis and recycling 0.789645309635468 -0.236171409485566 30 2 0.00205973223480947 971 10287 90423,55240 ATP6V1E2,STEAP3 R-HSA-420029 Tight junction interactions 0.789645309635468 -0.236171409485566 30 2 0.00205973223480947 971 10287 9069,10207 CLDN12,PATJ R-HSA-5683826 Surfactant metabolism 0.789645309635468 -0.236171409485566 30 2 0.00205973223480947 971 10287 10970,29995 CKAP4,LMCD1 R-HSA-1295596 Spry regulation of FGF signaling 0.795580066799778 -0.228683786615106 16 1 0.00102986611740474 971 10287 10253 SPRY2 R-HSA-418038 Nucleotide-like (purinergic) receptors 0.795580066799778 -0.228683786615106 16 1 0.00102986611740474 971 10287 5028 P2RY1 R-HSA-159418 Recycling of bile acids and salts 0.795580066799778 -0.228683786615106 16 1 0.00102986611740474 971 10287 2172 FABP6 R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.798450910374762 -0.225081790518364 82 6 0.00617919670442842 971 10287 54732,55605,662,23046,23095,3798 TMED9,KIF21A,BNIP1,KIF21B,KIF1B,KIF5A R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.802769127064793 -0.219688119370437 70 5 0.00514933058702369 971 10287 9261,5903,9531,3306,116835 MAPKAPK2,RANBP2,BAG3,HSPA2,HSPA12B R-HSA-202403 TCR signaling 0.802818874130579 -0.219626151959414 119 9 0.00926879505664264 971 10287 5788,5058,51466,5795,55740,1147,5588,3937,8945 PTPRC,PAK1,EVL,PTPRJ,ENAH,CHUK,PRKCQ,LCP2,BTRC R-HSA-1296065 Inwardly rectifying K+ channels 0.804729451766953 -0.217249142814264 31 2 0.00205973223480947 971 10287 55970,3761 GNG12,KCNJ4 R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.804729451766953 -0.217249142814264 31 2 0.00205973223480947 971 10287 5608,10000 MAP2K6,AKT3 R-HSA-180786 Extension of Telomeres 0.804729451766953 -0.217249142814264 31 2 0.00205973223480947 971 10287 55651,7015 NHP2,TERT R-HSA-1280218 Adaptive Immune System 0.807220385348579 -0.214158555865466 810 70 0.0720906282183316 971 10287 5071,685,26052,3798,8673,10859,57520,55740,1147,3709,3937,821,143279,114907,7220,64219,4233,7099,10125,5567,5159,3695,51466,26249,5777,192670,5588,8822,958,2260,8660,114088,10718,5795,154214,57630,5579,3082,55819,57531,91694,9902,90293,9871,5966,26272,51191,6402,55008,1780,4734,118788,5592,8139,6850,80329,5058,2264,153579,3164,11069,10333,5788,57761,6456,10000,374383,1515,126433,8945 PRKN,BTC,DNM3,KIF5A,VAMP8,LILRB1,HECW2,ENAH,CHUK,ITPR2,LCP2,CANX,HECTD2,FBXO32,TRPC1,PJA1,MET,TLR4,RASGRP1,PRKACB,PDGFRB,ITGB7,EVL,KLHL3,PTPN6,AGO4,PRKCQ,FGF17,CD40,FGFR1,IRS2,TRIM9,NRG3,PTPRJ,RNF217,SH3RF1,PRKCB,HGF,RNF130,HACE1,LONRF1,MRC2,KLHL13,SEC24D,REL,FBXO4,HERC5,SELL,HERC6,DYNC1I1,NEDD4,PIK3AP1,PRKG1,GAN,SYK,ULBP1,PAK1,FGFR4,BTNL9,NR4A1,RAPGEF4,TLR6,PTPRC,TRIB3,SH3GL2,AKT3,NCR3LG1,CTSV,FBXO27,BTRC R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.810782035258516 -0.209756021459678 45 3 0.00308959835221421 971 10287 6604,10891,4208 SMARCD3,PPARGC1A,MEF2C R-HSA-6811438 Intra-Golgi traffic 0.810782035258516 -0.209756021459678 45 3 0.00308959835221421 971 10287 83548,9265,27314 COG3,CYTH3,RAB30 R-HSA-8854214 TBC/RABGAPs 0.810782035258516 -0.209756021459678 45 3 0.00308959835221421 971 10287 125058,51560,55357 TBC1D16,RAB6B,TBC1D2 R-HSA-2033519 Activated point mutants of FGFR2 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-1482922 Acyl chain remodelling of PI 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 5321 PLA2G4A R-HSA-442729 CREB phosphorylation through the activation of CaMKII 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 2906 GRIN2D R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 2906 GRIN2D R-HSA-622312 Inflammasomes 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 10910 SUGT1 R-HSA-3232118 SUMOylation of transcription factors 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 7020 TFAP2A R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 57530 CGN R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.814905522485801 -0.204683095791208 17 1 0.00102986611740474 971 10287 178 AGL R-HSA-416476 G alpha (q) signalling events 0.81528331381171 -0.204219601839759 192 15 0.0154479917610711 971 10287 747,55970,9170,8477,59345,5580,5588,5021,3709,5028,57406,7222,23236,10125,1131 DAGLA,GNG12,LPAR2,GPR65,GNB4,PRKCD,PRKCQ,OXTR,ITPR2,P2RY1,ABHD6,TRPC3,PLCB1,RASGRP1,CHRM3 R-HSA-5663205 Infectious disease 0.816843009743507 -0.202308357122894 388 32 0.0329557157569516 971 10287 6224,9899,5611,3843,4869,821,1794,23521,6164,1938,6205,2963,4233,51121,6228,6207,6154,118429,6144,6616,6875,5903,6136,155382,3839,6158,6456,5608,6206,6124,8945,92421 RPS20,SV2B,DNAJC3,IPO5,NPM1,CANX,DOCK2,RPL13A,RPL34,EEF2,RPS11,GTF2F2,MET,RPL26L1,RPS23,RPS13,RPL26,ANTXR2,RPL21,SNAP25,TAF4B,RANBP2,RPL12,VPS37D,KPNA3,RPL28,SH3GL2,MAP2K6,RPS12,RPL4,BTRC,CHMP4C R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.818843723963298 -0.199862026567855 32 2 0.00205973223480947 971 10287 4040,8321 LRP6,FZD1 R-HSA-196071 Metabolism of steroid hormones 0.818843723963298 -0.199862026567855 32 2 0.00205973223480947 971 10287 79644,134429 SRD5A3,STARD4 R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.818843723963298 -0.199862026567855 32 2 0.00205973223480947 971 10287 55970,59345 GNG12,GNB4 R-HSA-2559585 Oncogene Induced Senescence 0.818843723963298 -0.199862026567855 32 2 0.00205973223480947 971 10287 192670,3397 AGO4,ID1 R-HSA-1980143 Signaling by NOTCH1 0.831266090651143 -0.184805330025114 73 5 0.00514933058702369 971 10287 92737,26508,4609,1272,23462 DNER,HEYL,MYC,CNTN1,HEY1 R-HSA-3214841 PKMTs methylate histone lysines 0.831266090651143 -0.184805330025114 73 5 0.00514933058702369 971 10287 7468,64324,83852,64754,2122 NSD2,NSD1,SETDB2,SMYD3,MECOM R-HSA-1839126 FGFR2 mutant receptor activation 0.832036609303485 -0.18387883756228 33 2 0.00205973223480947 971 10287 8822,2963 FGF17,GTF2F2 R-HSA-1222556 ROS, RNS production in phagocytes 0.832036609303485 -0.18387883756228 33 2 0.00205973223480947 971 10287 90423,4846 ATP6V1E2,NOS3 R-HSA-180746 Nuclear import of Rev protein 0.832036609303485 -0.18387883756228 33 2 0.00205973223480947 971 10287 4869,5903 NPM1,RANBP2 R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 4311 MME R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 9261 MAPKAPK2 R-HSA-5654704 SHC-mediated cascade:FGFR3 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-912631 Regulation of signaling by CBL 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 6850 SYK R-HSA-5635838 Activation of SMO 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 2619 GAS1 R-HSA-5654710 PI-3K cascade:FGFR3 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-69205 G1/S-Specific Transcription 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-1482925 Acyl chain remodelling of PG 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 5321 PLA2G4A R-HSA-210993 Tie2 Signaling 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 2888 GRB14 R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.83240569167576 -0.183435346816933 18 1 0.00102986611740474 971 10287 9261 MAPKAPK2 R-HSA-4570464 SUMOylation of RNA binding proteins 0.844104803864217 -0.169478616900711 48 3 0.00308959835221421 971 10287 5903,7703,1911 RANBP2,PCGF2,PHC1 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.844104803864217 -0.169478616900711 48 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 0.844104803864217 -0.169478616900711 48 3 0.00308959835221421 971 10287 6604,1628,10891 SMARCD3,DBP,PPARGC1A R-HSA-5654727 Negative regulation of FGFR2 signaling 0.844356088352236 -0.169180967732723 34 2 0.00205973223480947 971 10287 8822,10253 FGF17,SPRY2 R-HSA-192105 Synthesis of bile acids and bile salts 0.844356088352236 -0.169180967732723 34 2 0.00205973223480947 971 10287 11001,114880 SLC27A2,OSBPL6 R-HSA-3928663 EPHA-mediated growth cone collapse 0.844356088352236 -0.169180967732723 34 2 0.00205973223480947 971 10287 2042,1944 EPHA3,EFNA3 R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.844356088352236 -0.169180967732723 34 2 0.00205973223480947 971 10287 10382,7846 TUBB4A,TUBA1A R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.844773995911759 -0.168686147858347 100 7 0.00720906282183316 971 10287 10382,27077,5577,91147,7846,79867,4867 TUBB4A,B9D1,PRKAR2B,TMEM67,TUBA1A,TCTN2,NPHP1 R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 0.848252811480324 -0.164576560875516 19 1 0.00102986611740474 971 10287 5602 MAPK10 R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.848252811480324 -0.164576560875516 19 1 0.00102986611740474 971 10287 590 BCHE R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.848252811480324 -0.164576560875516 19 1 0.00102986611740474 971 10287 9896 FIG4 R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.848252811480324 -0.164576560875516 19 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-5654738 Signaling by FGFR2 0.848333861023369 -0.16448101663434 75 5 0.00514933058702369 971 10287 8822,10253,23543,54845,2963 FGF17,SPRY2,RBFOX2,ESRP1,GTF2F2 R-HSA-6783783 Interleukin-10 signaling 0.854022927000801 -0.157797238948777 49 3 0.00308959835221421 971 10287 3627,1435,7132 CXCL10,CSF1,TNFRSF1A R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.855849302425809 -0.155660966906743 35 2 0.00205973223480947 971 10287 2335,3690 FN1,ITGB3 R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.855849302425809 -0.155660966906743 35 2 0.00205973223480947 971 10287 5588,5578 PRKCQ,PRKCA R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.856317103026153 -0.155114523978655 76 5 0.00514933058702369 971 10287 51191,5903,317649,3839,4734 HERC5,RANBP2,EIF4E3,KPNA3,NEDD4 R-HSA-1169408 ISG15 antiviral mechanism 0.856317103026153 -0.155114523978655 76 5 0.00514933058702369 971 10287 51191,5903,317649,3839,4734 HERC5,RANBP2,EIF4E3,KPNA3,NEDD4 R-HSA-190241 FGFR2 ligand binding and activation 0.862602881626897 -0.147800854144602 20 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-5654706 FRS-mediated FGFR3 signaling 0.862602881626897 -0.147800854144602 20 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.862602881626897 -0.147800854144602 20 1 0.00102986611740474 971 10287 3977 LIFR R-HSA-5687128 MAPK6/MAPK4 signaling 0.863991895210756 -0.146191890765186 90 6 0.00617919670442842 971 10287 5058,192670,5596,8555,4609,5567 PAK1,AGO4,MAPK4,CDC14B,MYC,PRKACB R-HSA-428157 Sphingolipid metabolism 0.863991895210756 -0.146191890765186 90 6 0.00617919670442842 971 10287 8611,7368,79603,10715,340485,8612 PLPP1,UGT8,CERS4,CERS1,ACER2,PLPP2 R-HSA-446203 Asparagine N-linked glycosylation 0.864114790095075 -0.146049660096708 284 22 0.0226570545829042 971 10287 1604,9871,7039,4597,6480,287,11282,80267,256435,821,1780,9486,89866,4245,79644,440138,10960,54732,83548,6489,9331,144245 CD55,SEC24D,TGFA,MVD,ST6GAL1,ANK2,MGAT4B,EDEM3,ST6GALNAC3,CANX,DYNC1I1,CHST10,SEC16B,MGAT1,SRD5A3,ALG11,LMAN2,TMED9,COG3,ST8SIA1,B4GALT6,ALG10B R-HSA-2132295 MHC class II antigen presentation 0.865377124444595 -0.14458988504593 103 7 0.00720906282183316 971 10287 26052,6456,821,9871,1780,3798,1515 DNM3,SH3GL2,CANX,SEC24D,DYNC1I1,KIF5A,CTSV R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.866562284442826 -0.143221291921784 36 2 0.00205973223480947 971 10287 821,80267 CANX,EDEM3 R-HSA-2514856 The phototransduction cascade 0.866562284442826 -0.143221291921784 36 2 0.00205973223480947 971 10287 5588,5578 PRKCQ,PRKCA R-HSA-177243 Interactions of Rev with host cellular proteins 0.866562284442826 -0.143221291921784 36 2 0.00205973223480947 971 10287 4869,5903 NPM1,RANBP2 R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.873566909522474 -0.135170553002769 191 14 0.0144181256436663 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,55651,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,NHP2,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.874217513248745 -0.134426063295862 179 13 0.0133882595262616 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.874217513248745 -0.134426063295862 179 13 0.0133882595262616 971 10287 5321,2589,662,51560,3798,9265,54732,55605,83548,23046,1780,23095,27314 PLA2G4A,GALNT1,BNIP1,RAB6B,KIF5A,CYTH3,TMED9,KIF21A,COG3,KIF21B,DYNC1I1,KIF1B,RAB30 R-HSA-5423646 Aflatoxin activation and detoxification 0.875597193690909 -0.132849118351232 21 1 0.00102986611740474 971 10287 4259 MGST3 R-HSA-3000480 Scavenging by Class A Receptors 0.875597193690909 -0.132849118351232 21 1 0.00102986611740474 971 10287 4481 MSR1 R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.875597193690909 -0.132849118351232 21 1 0.00102986611740474 971 10287 1272 CNTN1 R-HSA-5617833 Cilium Assembly 0.878151012590844 -0.129936704019523 192 14 0.0144181256436663 971 10287 10382,27077,28981,91147,7846,79867,57728,51626,92104,5577,79659,27241,4867,150737 TUBB4A,B9D1,IFT81,TMEM67,TUBA1A,TCTN2,WDR19,DYNC2LI1,TTC30A,PRKAR2B,DYNC2H1,BBS9,NPHP1,TTC30B R-HSA-6807878 COPI-mediated anterograde transport 0.878186199002513 -0.129896636074209 79 5 0.00514933058702369 971 10287 54732,1604,83548,1780,287 TMED9,CD55,COG3,DYNC1I1,ANK2 R-HSA-3214842 HDMs demethylate histones 0.880537537880771 -0.127222719494908 52 3 0.00308959835221421 971 10287 80853,10765,84159 KDM7A,KDM5B,ARID5B R-HSA-901032 ER Quality Control Compartment (ERQC) 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 80267 EDEM3 R-HSA-8853338 Signaling by FGFR3 point mutants in cancer 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-69273 Cyclin A/B1 associated events during G2/M transition 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-5655332 Signaling by FGFR3 in disease 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-373753 Nephrin interactions 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 9863 MAGI2 R-HSA-389513 CTLA4 inhibitory signaling 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 10000 AKT3 R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 6296 ACSM3 R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.887363716660946 -0.119500328115801 22 1 0.00102986611740474 971 10287 5627 PROS1 R-HSA-4608870 Asymmetric localization of PCP proteins 0.888383721178099 -0.118351510882449 67 4 0.00411946446961895 971 10287 144165,8322,8325,8321 PRICKLE1,FZD4,FZD8,FZD1 R-HSA-199977 ER to Golgi Anterograde Transport 0.891493126200084 -0.114857552084344 133 9 0.00926879505664264 971 10287 1604,89866,9871,7039,287,54732,10960,83548,1780 CD55,SEC16B,SEC24D,TGFA,ANK2,TMED9,LMAN2,COG3,DYNC1I1 R-HSA-6783310 Fanconi Anemia Pathway 0.894459456497084 -0.111535702385256 39 2 0.00205973223480947 971 10287 79008,199990 SLX1B,FAAP20 R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.894459456497084 -0.111535702385256 39 2 0.00205973223480947 971 10287 2335,3690 FN1,ITGB3 R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.894459456497084 -0.111535702385256 39 2 0.00205973223480947 971 10287 2335,3690 FN1,ITGB3 R-HSA-1169091 Activation of NF-kappaB in B cells 0.895048874137893 -0.110876954222944 68 4 0.00411946446961895 971 10287 1147,5579,5966,8945 CHUK,PRKCB,REL,BTRC R-HSA-73980 RNA Polymerase III Transcription Termination 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 4774 NFIA R-HSA-389948 PD-1 signaling 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 5777 PTPN6 R-HSA-379726 Mitochondrial tRNA aminoacylation 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 2617 GARS R-HSA-3371571 HSF1-dependent transactivation 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 3306 HSPA2 R-HSA-8855121 VLDL interactions 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 7436 VLDLR R-HSA-5654695 PI-3K cascade:FGFR2 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-5654699 SHC-mediated cascade:FGFR2 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-5365859 RA biosynthesis pathway 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 1592 CYP26A1 R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.898018351953506 -0.107564774414922 23 1 0.00102986611740474 971 10287 27241 BBS9 R-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport 0.901361832121033 -0.103848512509769 69 4 0.00411946446961895 971 10287 10960,89866,9871,7039 LMAN2,SEC16B,SEC24D,TGFA R-HSA-388841 Costimulation by the CD28 family 0.901361832121033 -0.103848512509769 69 4 0.00411946446961895 971 10287 5058,57761,10000,5777 PAK1,TRIB3,AKT3,PTPN6 R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.902483286479931 -0.102605108082393 40 2 0.00205973223480947 971 10287 11328,26272 FKBP9,FBXO4 R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.902483286479931 -0.102605108082393 40 2 0.00205973223480947 971 10287 5903,3839 RANBP2,KPNA3 R-HSA-5658442 Regulation of RAS by GAPs 0.90733714758428 -0.097241180644277 70 4 0.00411946446961895 971 10287 22821,153090,399473,9462 RASA3,DAB2IP,SPRED3,RASAL2 R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.907666070212964 -0.0968787321052777 24 1 0.00102986611740474 971 10287 9826 ARHGEF11 R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.907666070212964 -0.0968787321052777 24 1 0.00102986611740474 971 10287 11001 SLC27A2 R-HSA-156588 Glucuronidation 0.907666070212964 -0.0968787321052777 24 1 0.00102986611740474 971 10287 7358 UGDH R-HSA-913531 Interferon Signaling 0.913687098809564 -0.0902671087997333 201 14 0.0144181256436663 971 10287 5903,317649,23321,3839,53840,2633,5777,5580,10612,51191,4684,4281,4734,3669 RANBP2,EIF4E3,TRIM2,KPNA3,TRIM34,GBP1,PTPN6,PRKCD,TRIM3,HERC5,NCAM1,MID1,NEDD4,ISG20 R-HSA-72312 rRNA processing 0.913687098809564 -0.0902671087997333 201 14 0.0144181256436663 971 10287 6224,6154,6136,6158,6205,6144,6206,6124,55651,51121,6228,23521,6207,6164 RPS20,RPL26,RPL12,RPL28,RPS11,RPL21,RPS12,RPL4,NHP2,RPL26L1,RPS23,RPL13A,RPS13,RPL34 R-HSA-211981 Xenobiotics 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 1573 CYP2J2 R-HSA-429947 Deadenylation of mRNA 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 85456 TNKS1BP1 R-HSA-5654700 FRS-mediated FGFR2 signaling 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 2731 GLDC R-HSA-203927 MicroRNA (miRNA) biogenesis 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 192670 AGO4 R-HSA-933542 TRAF6 mediated NF-kB activation 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-1538133 G0 and Early G1 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-5654708 Downstream signaling of activated FGFR3 0.916401941389241 -0.0873002099095786 25 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.916849944936439 -0.086811457044293 42 2 0.00205973223480947 971 10287 9781,220441 RNF144A,RNF152 R-HSA-168253 Host Interactions with Influenza Factors 0.916849944936439 -0.086811457044293 42 2 0.00205973223480947 971 10287 5903,3839 RANBP2,KPNA3 R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.916849944936439 -0.086811457044293 42 2 0.00205973223480947 971 10287 1787,221078 TRDMT1,NSUN6 R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.921046088968856 -0.0822452016674435 58 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.921046088968856 -0.0822452016674435 58 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.921046088968856 -0.0822452016674435 58 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.921046088968856 -0.0822452016674435 58 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.921046088968856 -0.0822452016674435 58 3 0.00308959835221421 971 10287 26508,4609,23462 HEYL,MYC,HEY1 R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.92146919828462 -0.0817859280580161 373 28 0.0288362512873326 971 10287 91694,5071,9902,26249,9871,90293,26272,8673,51191,57520,1147,55008,821,10333,143279,4734,114088,114907,154214,57630,1515,8139,55819,64219,126433,7099,8945,57531 LONRF1,PRKN,MRC2,KLHL3,SEC24D,KLHL13,FBXO4,VAMP8,HERC5,HECW2,CHUK,HERC6,CANX,TLR6,HECTD2,NEDD4,TRIM9,FBXO32,RNF217,SH3RF1,CTSV,GAN,RNF130,PJA1,FBXO27,TLR4,BTRC,HACE1 R-HSA-168325 Viral Messenger RNA Synthesis 0.923263901500667 -0.0798401682269786 43 2 0.00205973223480947 971 10287 5903,2963 RANBP2,GTF2F2 R-HSA-5655253 Signaling by FGFR2 in disease 0.923263901500667 -0.0798401682269786 43 2 0.00205973223480947 971 10287 8822,2963 FGF17,GTF2F2 R-HSA-5362517 Signaling by Retinoic Acid 0.923263901500667 -0.0798401682269786 43 2 0.00205973223480947 971 10287 5163,1592 PDK1,CYP26A1 R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.923263901500667 -0.0798401682269786 43 2 0.00205973223480947 971 10287 3512,4481 JCHAIN,MSR1 R-HSA-912694 Regulation of IFNA signaling 0.924312067571136 -0.0787055288936397 26 1 0.00102986611740474 971 10287 5777 PTPN6 R-HSA-73848 Pyrimidine metabolism 0.924312067571136 -0.0787055288936397 26 1 0.00102986611740474 971 10287 1890 TYMP R-HSA-1236975 Antigen processing-Cross presentation 0.924378058429602 -0.0786341368765947 101 6 0.00617919670442842 971 10287 1147,9902,7099,10333,1515,8673 CHUK,MRC2,TLR4,TLR6,CTSV,VAMP8 R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.931474428203401 -0.0709865415949305 27 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-6783589 Interleukin-6 family signaling 0.931474428203401 -0.0709865415949305 27 1 0.00102986611740474 971 10287 3977 LIFR R-HSA-77387 Insulin receptor recycling 0.931474428203401 -0.0709865415949305 27 1 0.00102986611740474 971 10287 90423 ATP6V1E2 R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.931474428203401 -0.0709865415949305 27 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-3371556 Cellular response to heat stress 0.931741445698154 -0.070699921563058 89 5 0.00514933058702369 971 10287 9261,5903,9531,3306,116835 MAPKAPK2,RANBP2,BAG3,HSPA2,HSPA12B R-HSA-5610780 Degradation of GLI1 by the proteasome 0.936191750673124 -0.0659349616556033 61 3 0.00308959835221421 971 10287 5567,8945,2735 PRKACB,BTRC,GLI1 R-HSA-2022854 Keratan sulfate biosynthesis 0.937959645569615 -0.0640483526821697 28 1 0.00102986611740474 971 10287 9331 B4GALT6 R-HSA-70268 Pyruvate metabolism 0.937959645569615 -0.0640483526821697 28 1 0.00102986611740474 971 10287 5163 PDK1 R-HSA-5621480 Dectin-2 family 0.937959645569615 -0.0640483526821697 28 1 0.00102986611740474 971 10287 6850 SYK R-HSA-8852135 Protein ubiquitination 0.940612191662474 -0.061224347974843 62 3 0.00308959835221421 971 10287 7347,9781,220441 UCHL3,RNF144A,RNF152 R-HSA-1268020 Mitochondrial protein import 0.940612191662474 -0.061224347974843 62 3 0.00308959835221421 971 10287 79145,197257,134266 CHCHD7,LDHD,GRPEL2 R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.943831678325144 -0.0578074355941516 29 1 0.00102986611740474 971 10287 1147 CHUK R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.943831678325144 -0.0578074355941516 29 1 0.00102986611740474 971 10287 1794 DOCK2 R-HSA-72086 mRNA Capping 0.943831678325144 -0.0578074355941516 29 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.943831678325144 -0.0578074355941516 29 1 0.00102986611740474 971 10287 11022 TDRKH R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-73776 RNA Polymerase II Promoter Escape 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-167161 HIV Transcription Initiation 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-75953 RNA Polymerase II Transcription Initiation 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-167162 RNA Polymerase II HIV Promoter Escape 0.944538594745936 -0.0570587302540021 47 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-2871837 FCERI mediated NF-kB activation 0.948186360085327 -0.053204213678409 79 4 0.00411946446961895 971 10287 5588,1147,10125,8945 PRKCQ,CHUK,RASGRP1,BTRC R-HSA-380108 Chemokine receptors bind chemokines 0.94890528131209 -0.0524462942975097 48 2 0.00205973223480947 971 10287 643,3627 CXCR5,CXCL10 R-HSA-5633007 Regulation of TP53 Activity 0.948954335551503 -0.0523946000215081 162 10 0.0102986611740474 971 10287 5563,9099,5608,10000,8900,6446,639,900,6875,25946 PRKAA2,USP2,MAP2K6,AKT3,CCNA1,SGK1,PRDM1,CCNG1,TAF4B,ZNF385A R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.949148449661005 -0.0521900651441653 30 1 0.00102986611740474 971 10287 7347 UCHL3 R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.949148449661005 -0.0521900651441653 30 1 0.00102986611740474 971 10287 192670 AGO4 R-HSA-5654696 Downstream signaling of activated FGFR2 0.949148449661005 -0.0521900651441653 30 1 0.00102986611740474 971 10287 8822 FGF17 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.952227492263903 -0.04895131027567 65 3 0.00308959835221421 971 10287 57060,8900,25946 PCBP4,CCNA1,ZNF385A R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.952227492263903 -0.04895131027567 65 3 0.00308959835221421 971 10287 57060,8900,25946 PCBP4,CCNA1,ZNF385A R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.952942828318994 -0.0482003683982139 49 2 0.00205973223480947 971 10287 83548,51560 COG3,RAB6B R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.953962416261455 -0.0471310042622452 31 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.953962416261455 -0.0471310042622452 31 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.953962416261455 -0.0471310042622452 31 1 0.00102986611740474 971 10287 134353 LSM11 R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.953962416261455 -0.0471310042622452 31 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.958321083765574 -0.0425723966581502 32 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-69615 G1/S DNA Damage Checkpoints 0.95875341442138 -0.0421213649809322 67 3 0.00308959835221421 971 10287 57060,8900,25946 PCBP4,CCNA1,ZNF385A R-HSA-157118 Signaling by NOTCH 0.959837299118164 -0.0409914889688736 112 6 0.00617919670442842 971 10287 192670,92737,26508,4609,1272,23462 AGO4,DNER,HEYL,MYC,CNTN1,HEY1 R-HSA-1638074 Keratan sulfate/keratin metabolism 0.96226747360903 -0.038462827867511 33 1 0.00102986611740474 971 10287 9331 B4GALT6 R-HSA-1980145 Signaling by NOTCH2 0.96226747360903 -0.038462827867511 33 1 0.00102986611740474 971 10287 1272 CNTN1 R-HSA-180910 Vpr-mediated nuclear import of PICs 0.96226747360903 -0.038462827867511 33 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.962980442377839 -0.0377221764475233 84 4 0.00411946446961895 971 10287 54941,51191,1147,9474 RNF125,HERC5,CHUK,ATG5 R-HSA-1236974 ER-Phagosome pathway 0.965423351428986 -0.0351885677025289 85 4 0.00411946446961895 971 10287 1147,7099,10333,8673 CHUK,TLR4,TLR6,VAMP8 R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.96584054586572 -0.034756524786169 34 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-113510 E2F mediated regulation of DNA replication 0.96584054586572 -0.034756524786169 34 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.96584054586572 -0.034756524786169 34 1 0.00102986611740474 971 10287 79008 SLX1B R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.96584054586572 -0.034756524786169 34 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.967614090018016 -0.0329219385312699 101 5 0.00514933058702369 971 10287 1147,3709,6850,5580,8945 CHUK,ITPR2,SYK,PRKCD,BTRC R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.969075582449797 -0.0314126696690625 35 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-113418 Formation of the Early Elongation Complex 0.969075582449797 -0.0314126696690625 35 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.969075582449797 -0.0314126696690625 35 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-5693537 Resolution of D-Loop Structures 0.969075582449797 -0.0314126696690625 35 1 0.00102986611740474 971 10287 79008 SLX1B R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.969075582449797 -0.0314126696690625 35 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-73856 RNA Polymerase II Transcription Termination 0.969375149179445 -0.0311035911589456 71 3 0.00308959835221421 971 10287 8563,134353,84321 THOC5,LSM11,THOC3 R-HSA-109688 Cleavage of Growing Transcript in the Termination Region 0.969375149179445 -0.0311035911589456 71 3 0.00308959835221421 971 10287 8563,134353,84321 THOC5,LSM11,THOC3 R-HSA-212436 Generic Transcription Pathway 0.969736105232766 -0.0307313009598472 865 67 0.0690010298661174 971 10287 282890,4869,85456,6497,79047,5366,604,55240,10794,64065,3486,83667,2649,7039,665,147929,10413,192670,27244,148266,4088,7552,10781,90874,10769,8900,25937,619279,27113,4306,55762,284252,58528,5563,860,219749,7762,8794,54541,6940,126070,4609,57060,7020,2963,27166,6446,9443,25946,9099,10765,3174,3164,2104,100289635,6604,639,900,6875,148206,148156,5325,7761,10000,5608,2810,9310 ZNF311,NPM1,TNKS1BP1,SKI,KCTD15,PMAIP1,BCL6,STEAP3,ZNF460,PERP,IGFBP3,SESN2,NR6A1,TGFA,BNIP3L,ZNF565,YAP1,AGO4,SESN1,ZNF569,SMAD3,ZNF711,ZNF266,ZNF697,PLK2,CCNA1,WWTR1,ZNF704,BBC3,NR3C2,ZNF701,KCTD1,RRAGD,PRKAA2,RUNX2,ZNF25,ZNF215,TNFRSF10C,DDIT4,ZNF354A,ZNF440,MYC,PCBP4,TFAP2A,GTF2F2,PRELID1,SGK1,MED7,ZNF385A,USP2,KDM5B,HNF4G,NR4A1,ESRRG,ZNF605,SMARCD3,PRDM1,CCNG1,TAF4B,ZNF714,ZNF558,PLAGL1,ZNF214,AKT3,MAP2K6,SFN,ZNF235 R-HSA-69202 Cyclin E associated events during G1/S transition 0.971594420357657 -0.0288168246066557 72 3 0.00308959835221421 971 10287 10000,4609,8900 AKT3,MYC,CCNA1 R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.971594420357657 -0.0288168246066557 72 3 0.00308959835221421 971 10287 10382,5577,7846 TUBB4A,PRKAR2B,TUBA1A R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.971594420357657 -0.0288168246066557 72 3 0.00308959835221421 971 10287 10382,5577,7846 TUBB4A,PRKAR2B,TUBA1A R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.972004533822323 -0.0283948101063182 36 1 0.00102986611740474 971 10287 2649 NR6A1 R-HSA-176033 Interactions of Vpr with host cellular proteins 0.972004533822323 -0.0283948101063182 36 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.973660786689407 -0.0266923042851155 73 3 0.00308959835221421 971 10287 5452,26512,2963 POU2F2,INTS6,GTF2F2 R-HSA-418594 G alpha (i) signalling events 0.974000444175599 -0.0263435193072639 242 15 0.0154479917610711 971 10287 643,6004,55970,3627,9170,50865,59345,6001,26086,107,23596,8601,112,6000,2770 CXCR5,RGS16,GNG12,CXCL10,LPAR2,HEBP1,GNB4,RGS10,GPSM1,ADCY1,OPN3,RGS20,ADCY6,RGS7,GNAI1 R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.975539615095394 -0.024764509702128 90 4 0.00411946446961895 971 10287 10382,5577,7846,8945 TUBB4A,PRKAR2B,TUBA1A,BTRC R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.977057182244746 -0.0232101002541766 38 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.977057182244746 -0.0232101002541766 38 1 0.00102986611740474 971 10287 475 ATOX1 R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.977057182244746 -0.0232101002541766 38 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.97719650576886 -0.0230675153633769 91 4 0.00411946446961895 971 10287 83439,26108,7015,4609 TCF7L1,PYGO1,TERT,MYC R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 0.977373308647572 -0.0228866030440625 75 3 0.00308959835221421 971 10287 7468,2070,322 NSD2,EYA4,APBB1 R-HSA-8854518 AURKA Activation by TPX2 0.977373308647572 -0.0228866030440625 75 3 0.00308959835221421 971 10287 10382,5577,7846 TUBB4A,PRKAR2B,TUBA1A R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.977373308647572 -0.0228866030440625 75 3 0.00308959835221421 971 10287 5903,8563,84321 RANBP2,THOC5,THOC3 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.97856423493959 -0.0216688479648227 311 20 0.0205973223480947 971 10287 91694,5071,26249,90293,26272,51191,57520,55008,143279,4734,114088,114907,154214,57630,8139,55819,64219,126433,8945,57531 LONRF1,PRKN,KLHL3,KLHL13,FBXO4,HERC5,HECW2,HERC6,HECTD2,NEDD4,TRIM9,FBXO32,RNF217,SH3RF1,GAN,RNF130,PJA1,FBXO27,BTRC,HACE1 R-HSA-5693606 DNA Double Strand Break Response 0.979037373341428 -0.0211854621634937 76 3 0.00308959835221421 971 10287 7468,2070,322 NSD2,EYA4,APBB1 R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.980735525771922 -0.019452452327231 124 6 0.00617919670442842 971 10287 6402,10859,3695,958,374383,80329 SELL,LILRB1,ITGB7,CD40,NCR3LG1,ULBP1 R-HSA-167287 HIV elongation arrest and recovery 0.981198691727079 -0.0189802999383994 40 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-167290 Pausing and recovery of HIV elongation 0.981198691727079 -0.0189802999383994 40 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.981311822674523 -0.0188650078706736 60 2 0.00205973223480947 971 10287 1147,8945 CHUK,BTRC R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 0.982022090183179 -0.0181414757857946 78 3 0.00308959835221421 971 10287 5903,7703,1911 RANBP2,PCGF2,PHC1 R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.982841316656527 -0.0173075994787025 61 2 0.00205973223480947 971 10287 5567,8945 PRKACB,BTRC R-HSA-5610783 Degradation of GLI2 by the proteasome 0.982841316656527 -0.0173075994787025 61 2 0.00205973223480947 971 10287 5567,8945 PRKACB,BTRC R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.982841316656527 -0.0173075994787025 61 2 0.00205973223480947 971 10287 1147,8945 CHUK,BTRC R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.982980293193656 -0.0171662066517394 41 1 0.00102986611740474 971 10287 4774 NFIA R-HSA-5696400 Dual Incision in GG-NER 0.982980293193656 -0.0171662066517394 41 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-74158 RNA Polymerase III Transcription 0.982980293193656 -0.0171662066517394 41 1 0.00102986611740474 971 10287 4774 NFIA R-HSA-2559580 Oxidative Stress Induced Senescence 0.983023816636052 -0.0171219306075691 126 6 0.00617919670442842 971 10287 9261,192670,23043,5602,5608,1911 MAPKAPK2,AGO4,TNIK,MAPK10,MAP2K6,PHC1 R-HSA-201681 TCF dependent signaling in response to WNT 0.983081498929759 -0.0170632538995955 238 14 0.0144181256436663 971 10287 83439,55366,7015,8322,51339,4609,8325,4040,25776,26108,83999,8945,8321,22943 TCF7L1,LGR4,TERT,FZD4,DACT1,MYC,FZD8,LRP6,CBY1,PYGO1,KREMEN1,BTRC,FZD1,DKK1 R-HSA-72187 mRNA 3'-end processing 0.984248954168515 -0.0158764117257687 62 2 0.00205973223480947 971 10287 8563,84321 THOC5,THOC3 R-HSA-195258 RHO GTPase Effectors 0.985365855520299 -0.0147422798477908 294 18 0.0185375901132853 971 10287 5058,10810,23433,51466,29984,3798,85415,5585,5217,10458,5903,644150,3071,29941,2017,128239,114793,2810 PAK1,WASF3,RHOQ,EVL,RHOD,KIF5A,RHPN2,PKN1,PFN2,BAIAP2,RANBP2,WIPF3,NCKAP1L,PKN3,CTTN,IQGAP3,FMNL2,SFN R-HSA-5696395 Formation of Incision Complex in GG-NER 0.986053450589382 -0.0140447163260852 43 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-5621481 C-type lectin receptors (CLRs) 0.986058376513942 -0.0140397207426781 144 7 0.00720906282183316 971 10287 5058,1147,3709,6850,5580,5567,8945 PAK1,CHUK,ITPR2,SYK,PRKCD,PRKACB,BTRC R-HSA-380287 Centrosome maturation 0.986818298606632 -0.0132693511196237 82 3 0.00308959835221421 971 10287 10382,5577,7846 TUBB4A,PRKAR2B,TUBA1A R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.986818298606632 -0.0132693511196237 82 3 0.00308959835221421 971 10287 10382,5577,7846 TUBB4A,PRKAR2B,TUBA1A R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.987375404855591 -0.0127049624653893 44 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.987809804399532 -0.0122651054343536 83 3 0.00308959835221421 971 10287 1488,83439,8945 CTBP2,TCF7L1,BTRC R-HSA-75955 RNA Polymerase II Transcription Elongation 0.987830859509198 -0.0122437907185237 65 2 0.00205973223480947 971 10287 4300,2963 MLLT3,GTF2F2 R-HSA-112382 Formation of RNA Pol II elongation complex 0.987830859509198 -0.0122437907185237 65 2 0.00205973223480947 971 10287 4300,2963 MLLT3,GTF2F2 R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.988572171610319 -0.0114936277970822 45 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-5663220 RHO GTPases Activate Formins 0.988822423352171 -0.0112405151974775 117 5 0.00514933058702369 971 10287 5903,51466,29984,5217,114793 RANBP2,EVL,RHOD,PFN2,FMNL2 R-HSA-977225 Amyloid fiber formation 0.988863581549848 -0.0111988926167634 101 4 0.00411946446961895 971 10287 5071,2934,23621,6622 PRKN,GSN,BACE1,SNCA R-HSA-4615885 SUMOylation of DNA replication proteins 0.989655594897016 -0.0103982803215658 46 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-1660662 Glycosphingolipid metabolism 0.989655594897016 -0.0103982803215658 46 1 0.00102986611740474 971 10287 7368 UGT8 R-HSA-5358346 Hedgehog ligand biogenesis 0.989763674097759 -0.0102890773825591 67 2 0.00205973223480947 971 10287 147111,85455 NOTUM,DISP2 R-HSA-5632684 Hedgehog 'on' state 0.990372425034995 -0.00967421969001894 86 3 0.00308959835221421 971 10287 2619,23432,2735 GAS1,GPR161,GLI1 R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.990614281699768 -0.00943004171027564 68 2 0.00205973223480947 971 10287 1147,7098 CHUK,TLR3 R-HSA-1912422 Pre-NOTCH Expression and Processing 0.990636399258063 -0.0094077148452214 47 1 0.00102986611740474 971 10287 192670 AGO4 R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 0.991062912606851 -0.0089772627046574 104 4 0.00411946446961895 971 10287 5903,7703,7020,1911 RANBP2,PCGF2,TFAP2A,PHC1 R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.991104812475323 -0.00893498589029008 87 3 0.00308959835221421 971 10287 5903,8563,84321 RANBP2,THOC5,THOC3 R-HSA-909733 Interferon alpha/beta signaling 0.991395723570266 -0.00864150693102491 69 2 0.00205973223480947 971 10287 5777,3669 PTPN6,ISG20 R-HSA-2559583 Cellular Senescence 0.991529518792774 -0.00850655961193048 196 10 0.0102986611740474 971 10287 1051,9261,23043,3397,6196,5608,8900,192670,5602,1911 CEBPB,MAPKAPK2,TNIK,ID1,RPS6KA2,MAP2K6,CCNA1,AGO4,MAPK10,PHC1 R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.991783292129906 -0.0082506510763536 88 3 0.00308959835221421 971 10287 6875,4300,2963 TAF4B,MLLT3,GTF2F2 R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.992328075968648 -0.00770150463105635 49 1 0.00102986611740474 971 10287 5163 PDK1 R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.99277254278031 -0.00725370181955983 71 2 0.00205973223480947 971 10287 4609,8900 MYC,CCNA1 R-HSA-382556 ABC-family proteins mediated transport 0.99284303403237 -0.00718269990668957 107 4 0.00411946446961895 971 10287 1244,10257,23461,9619 ABCC2,ABCC4,ABCA5,ABCG1 R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.993055702272174 -0.00696852157349565 50 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.993055702272174 -0.00696852157349565 50 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-167169 HIV Transcription Elongation 0.993055702272174 -0.00696852157349565 50 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.993531984294562 -0.00648902395581227 91 3 0.00308959835221421 971 10287 9261,5578,5580 MAPKAPK2,PRKCA,PRKCD R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.993714382863874 -0.00630545479917621 51 1 0.00102986611740474 971 10287 9902 MRC2 R-HSA-6799198 Complex I biogenesis 0.993714382863874 -0.00630545479917621 51 1 0.00102986611740474 971 10287 4714 NDUFB8 R-HSA-2990846 SUMOylation 0.994280119518772 -0.00573630164559099 110 4 0.00411946446961895 971 10287 5903,7703,7020,1911 RANBP2,PCGF2,TFAP2A,PHC1 R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.994310644506961 -0.00570560152493965 52 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.994491403800475 -0.00552382446556324 93 3 0.00308959835221421 971 10287 5563,6875,8900 PRKAA2,TAF4B,CCNA1 R-HSA-5625740 RHO GTPases activate PKNs 0.994491403800475 -0.00552382446556324 93 3 0.00308959835221421 971 10287 5585,29941,2810 PKN1,PKN3,SFN R-HSA-191859 snRNP Assembly 0.994850396755732 -0.00516290814735812 53 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-194441 Metabolism of non-coding RNA 0.994850396755732 -0.00516290814735812 53 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-180534 Vpu mediated degradation of CD4 0.994850396755732 -0.00516290814735812 53 1 0.00102986611740474 971 10287 8945 BTRC R-HSA-72165 mRNA Splicing - Minor Pathway 0.994850396755732 -0.00516290814735812 53 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-5620920 Cargo trafficking to the periciliary membrane 0.994850396755732 -0.00516290814735812 53 1 0.00102986611740474 971 10287 27241 BBS9 R-HSA-167172 Transcription of the HIV genome 0.995732853426519 -0.00427627682609578 77 2 0.00205973223480947 971 10287 6875,2963 TAF4B,GTF2F2 R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.99618161973925 -0.00382568888532864 56 1 0.00102986611740474 971 10287 8945 BTRC R-HSA-202424 Downstream TCR signaling 0.996325086721716 -0.00368168236103543 98 3 0.00308959835221421 971 10287 5588,1147,8945 PRKCQ,CHUK,BTRC R-HSA-1221632 Meiotic synapsis 0.996424466947064 -0.00358194054927876 79 2 0.00205973223480947 971 10287 10388,3306 SYCP2,HSPA2 R-HSA-429914 Deadenylation-dependent mRNA decay 0.996544013178315 -0.00346197253916068 57 1 0.00102986611740474 971 10287 85456 TNKS1BP1 R-HSA-372790 Signaling by GPCR 0.996739390195037 -0.00326593717658492 1299 97 0.0998970133882595 971 10287 643,5321,685,5153,9462,1850,50865,8477,8601,79339,3709,2870,5578,57406,26230,55160,2838,6196,65055,3690,153090,5144,4233,7253,343171,10125,5567,5159,9846,8321,1604,79924,8322,57580,107,5577,5588,7481,8822,157,2260,26084,2770,285601,3363,8660,3627,10718,5579,5924,59345,6001,153,3082,5021,282763,55970,6004,9170,2335,9826,8325,5028,6000,26575,23263,10846,5580,23596,112,4684,2674,1131,1843,2264,8643,11245,54756,10451,9693,26086,1852,10203,22821,84033,5151,390442,23236,2861,747,391195,64748,2775,10000,2906,399473,7222 CXCR5,PLA2G4A,BTC,PDE1B,RASAL2,DUSP8,HEBP1,GPR65,RGS20,OR51B4,ITPR2,GRK6,PRKCA,ABHD6,TIAM2,ARHGEF10L,GPR15,RPS6KA2,REEP1,ITGB3,DAB2IP,PDE4D,MET,TSHR,OR2W3,RASGRP1,PRKACB,PDGFRB,GAB2,FZD1,CD55,ADM2,FZD4,PREX1,ADCY1,PRKAR2B,PRKCQ,WNT11,FGF17,GRK3,FGFR1,ARHGEF26,GNAI1,GPR150,HTR7,IRS2,CXCL10,NRG3,PRKCB,RASGRF2,GNB4,RGS10,ADRB1,HGF,OXTR,OR51B5,GNG12,RGS16,LPAR2,FN1,ARHGEF11,FZD8,P2RY1,RGS7,RGS17,MCF2L,PDE10A,PRKCD,OPN3,ADCY6,NCAM1,GFRA1,CHRM3,DUSP1,FGFR4,PTCH2,GPR176,IL17RD,VAV3,RAPGEF2,GPSM1,DUSP9,CALCRL,RASA3,OBSCN,PDE8A,OR11H4,PLCB1,GPR37,DAGLA,OR2T33,PLPPR2,GNAO1,AKT3,GRIN2D,SPRED3,TRPC3 R-HSA-1852241 Organelle biogenesis and maintenance 0.996854191440297 -0.00315076701708587 340 19 0.01956745623069 971 10287 5563,27077,91147,7846,79867,92104,6604,29093,5577,27241,150737,10382,28981,57728,51626,79659,10891,4867,4208 PRKAA2,B9D1,TMEM67,TUBA1A,TCTN2,TTC30A,SMARCD3,MRPL22,PRKAR2B,BBS9,TTC30B,TUBB4A,IFT81,WDR19,DYNC2LI1,DYNC2H1,PPARGC1A,NPHP1,MEF2C R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.997005634272604 -0.00299885780998402 81 2 0.00205973223480947 971 10287 8900,8945 CCNA1,BTRC R-HSA-4641258 Degradation of DVL 0.997168969641773 -0.00283504530408479 59 1 0.00102986611740474 971 10287 51339 DACT1 R-HSA-392499 Metabolism of proteins 0.997244357898978 -0.00275944587221181 1619 124 0.127703398558187 971 10287 5071,9781,8434,3798,11226,79695,5611,29995,2625,11174,51299,821,9486,10382,11328,440,89866,399818,56605,25837,54732,5627,83548,5874,51121,374378,25924,55901,1363,22854,144245,3486,6207,8875,1604,468,7846,79875,7039,4597,287,253827,467,23682,6622,2770,4088,5903,3626,2934,59345,1978,7466,8900,2081,440138,27314,6224,55970,3489,9871,79145,23621,6480,26272,402,3800,114805,2621,6000,84749,1780,80055,23521,134266,6164,2589,152330,1938,4245,590,6205,4609,7020,10960,6489,55033,6228,10970,220441,9331,6154,5865,145173,9099,51560,11282,6144,80267,64409,256435,7347,79623,197257,9709,2822,257194,170691,2591,6136,6158,9508,2775,80731,7494,79644,7703,83729,11031,6124,6206,4311,1649,1911 PRKN,RNF144A,RECK,KIF5A,GALNT6,GALNT12,DNAJC3,LMCD1,GATA3,ADAMTS6,NRN1,CANX,CHST10,TUBB4A,FKBP9,ASNS,SEC16B,EEF1AKMT2,ERO1B,RAB26,TMED9,PROS1,COG3,RAB27B,RPL26L1,GALNT18,MYRIP,THSD1,CPE,NTNG1,ALG10B,IGFBP3,RPS13,VNN2,CD55,ATF4,TUBA1A,THSD4,TGFA,MVD,ANK2,MSRB3,ATF3,RAB38,SNCA,GNAI1,SMAD3,RANBP2,INHBC,GSN,GNB4,EIF4EBP1,WFS1,CCNA1,ERN1,ALG11,RAB30,RPS20,GNG12,IGFBP6,SEC24D,CHCHD7,BACE1,ST6GAL1,FBXO4,ARL2,KIF5C,GALNT13,GAS6,RGS7,USP30,DYNC1I1,PGAP1,RPL13A,GRPEL2,RPL34,GALNT1,CNTN4,EEF2,MGAT1,BCHE,RPS11,MYC,TFAP2A,LMAN2,ST8SIA1,FKBP14,RPS23,CKAP4,RNF152,B4GALT6,RPL26,RAB3B,B3GLCT,USP2,RAB6B,MGAT4B,RPL21,EDEM3,GALNT17,ST6GALNAC3,UCHL3,GALNT14,LDHD,HERPUD1,GPLD1,NEGR1,ADAMTS17,GALNT3,RPL12,RPL28,ADAMTS3,GNAO1,THSD7B,XBP1,SRD5A3,PCGF2,INHBE,RAB31,RPL4,RPS12,MME,DDIT3,PHC1 R-HSA-157579 Telomere Maintenance 0.997260317648934 -0.00274344214943053 82 2 0.00205973223480947 971 10287 55651,7015 NHP2,TERT R-HSA-6784531 tRNA processing in the nucleus 0.997437734835971 -0.00256555338347505 60 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-162599 Late Phase of HIV Life Cycle 0.997662064570935 -0.00234067266725614 139 5 0.00514933058702369 971 10287 5903,155382,6875,92421,2963 RANBP2,VPS37D,TAF4B,CHMP4C,GTF2F2 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.997681008488031 -0.00232168453699213 61 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.997901206111847 -0.00210099944258822 62 1 0.00102986611740474 971 10287 55651 NHP2 R-HSA-73857 RNA Polymerase II Transcription 0.998160882314565 -0.00184081093874498 159 6 0.00617919670442842 971 10287 8563,6875,4300,134353,84321,2963 THOC5,TAF4B,MLLT3,LSM11,THOC3,GTF2F2 R-HSA-453276 Regulation of mitotic cell cycle 0.998246703623477 -0.0017548351995531 87 2 0.00205973223480947 971 10287 8900,8945 CCNA1,BTRC R-HSA-351202 Metabolism of polyamines 0.998246703623477 -0.0017548351995531 87 2 0.00205973223480947 971 10287 445,2628 ASS1,GATM R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.998246703623477 -0.0017548351995531 87 2 0.00205973223480947 971 10287 8900,8945 CCNA1,BTRC R-HSA-72306 tRNA processing 0.998514641470093 -0.00148646276848358 109 3 0.00308959835221421 971 10287 1787,5903,221078 TRDMT1,RANBP2,NSUN6 R-HSA-73886 Chromosome Maintenance 0.998514641470093 -0.00148646276848358 109 3 0.00308959835221421 971 10287 4869,55651,7015 NPM1,NHP2,TERT R-HSA-6782135 Dual incision in TC-NER 0.998591983463651 -0.00140900872308536 66 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.998633366375936 -0.00136756831948256 110 3 0.00308959835221421 971 10287 1051,6196,8900 CEBPB,RPS6KA2,CCNA1 R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.998725745708432 -0.00127506684390639 67 1 0.00102986611740474 971 10287 5585 PKN1 R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.998846812358476 -0.00115385307401996 68 1 0.00102986611740474 971 10287 79008 SLX1B R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.998956387167059 -0.00104415777598618 69 1 0.00102986611740474 971 10287 7468 NSD2 R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.998956387167059 -0.00104415777598618 69 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-162909 Host Interactions of HIV factors 0.999105887448281 -0.000894512508768549 134 4 0.00411946446961895 971 10287 4869,5903,1794,8945 NPM1,RANBP2,DOCK2,BTRC R-HSA-162587 HIV Life Cycle 0.999112662503341 -0.000887731413617796 152 5 0.00514933058702369 971 10287 5903,155382,6875,92421,2963 RANBP2,VPS37D,TAF4B,CHMP4C,GTF2F2 R-HSA-69473 G2/M DNA damage checkpoint 0.999146713275941 -0.000853650980400212 95 2 0.00205973223480947 971 10287 7468,2810 NSD2,SFN R-HSA-68949 Orc1 removal from chromatin 0.999226552410145 -0.000773746854762049 72 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.999226552410145 -0.000773746854762049 72 1 0.00102986611740474 971 10287 4869 NPM1 R-HSA-69052 Switching of origins to a post-replicative state 0.999226552410145 -0.000773746854762049 72 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-774815 Nucleosome assembly 0.999226552410145 -0.000773746854762049 72 1 0.00102986611740474 971 10287 4869 NPM1 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.99930007347107 -0.000700171591860724 73 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-5693607 Processing of DNA double-strand break ends 0.99934978252474 -0.00065042895832034 98 2 0.00205973223480947 971 10287 7468,8900 NSD2,CCNA1 R-HSA-69206 G1/S Transition 0.999358417614544 -0.00064178828750772 119 3 0.00308959835221421 971 10287 10000,4609,8900 AKT3,MYC,CCNA1 R-HSA-69300 Removal of licensing factors from origins 0.999366612410022 -0.000633588264638776 74 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.999366612410022 -0.000633588264638776 74 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-1500620 Meiosis 0.999458457950701 -0.000541688736155506 121 3 0.00308959835221421 971 10287 10388,56154,3306 SYCP2,TEX15,HSPA2 R-HSA-597592 Post-translational protein modification 0.999475831234095 -0.00052430619037695 1034 70 0.0720906282183316 971 10287 5071,9781,8434,11226,79695,2625,11174,51299,821,9486,89866,399818,25837,54732,5627,83548,5874,374378,55901,22854,144245,8875,1604,79875,7039,287,4597,23682,4088,5903,8900,440138,27314,9871,6480,114805,2621,84749,1780,80055,2589,1938,152330,4245,4609,7020,10960,6489,9331,220441,5865,145173,9099,51560,11282,80267,64409,256435,7347,79623,257194,2822,170691,2591,9508,80731,79644,11031,7703,1911 PRKN,RNF144A,RECK,GALNT6,GALNT12,GATA3,ADAMTS6,NRN1,CANX,CHST10,SEC16B,EEF1AKMT2,RAB26,TMED9,PROS1,COG3,RAB27B,GALNT18,THSD1,NTNG1,ALG10B,VNN2,CD55,THSD4,TGFA,ANK2,MVD,RAB38,SMAD3,RANBP2,CCNA1,ALG11,RAB30,SEC24D,ST6GAL1,GALNT13,GAS6,USP30,DYNC1I1,PGAP1,GALNT1,EEF2,CNTN4,MGAT1,MYC,TFAP2A,LMAN2,ST8SIA1,B4GALT6,RNF152,RAB3B,B3GLCT,USP2,RAB6B,MGAT4B,EDEM3,GALNT17,ST6GALNAC3,UCHL3,GALNT14,NEGR1,GPLD1,ADAMTS17,GALNT3,ADAMTS3,THSD7B,SRD5A3,RAB31,PCGF2,PHC1 R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.999481330950554 -0.000518803604766087 76 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-68875 Mitotic Prophase 0.999488910371034 -0.000511220279788309 141 4 0.00411946446961895 971 10287 5903,64900,5578,5579 RANBP2,LPIN3,PRKCA,PRKCB R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.999530653008485 -0.000469457169289566 77 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-69304 Regulation of DNA replication 0.999530653008485 -0.000469457169289566 77 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-6805567 Keratinization 0.999609905271125 -0.000390170835617332 214 8 0.0082389289392379 971 10287 6768,23254,1829,5318,11005,1832,64065,5046 ST14,KAZN,DSG2,PKP2,SPINK5,DSP,PERP,PCSK6 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.999615684417828 -0.000384389450331413 79 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.999615684417828 -0.000384389450331413 79 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-3214858 RMTs methylate histone arginines 0.999615684417828 -0.000384389450331413 79 1 0.00102986611740474 971 10287 6604 SMARCD3 R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.999646301101963 -0.000353761464245578 126 3 0.00308959835221421 971 10287 9935,3198,7703 MAFB,HOXA1,PCGF2 R-HSA-5619507 Activation of HOX genes during differentiation 0.999646301101963 -0.000353761464245578 126 3 0.00308959835221421 971 10287 9935,3198,7703 MAFB,HOXA1,PCGF2 R-HSA-500792 GPCR ligand binding 0.999662548746233 -0.000337508203253625 453 24 0.0247167868177137 971 10287 643,8643,55970,9170,1604,8322,79924,50865,8477,8325,10203,7481,5028,2861,3363,3627,64748,59345,153,23596,5021,7253,1131,8321 CXCR5,PTCH2,GNG12,LPAR2,CD55,FZD4,ADM2,HEBP1,GPR65,FZD8,CALCRL,WNT11,P2RY1,GPR37,HTR7,CXCL10,PLPPR2,GNB4,ADRB1,OPN3,OXTR,TSHR,CHRM3,FZD1 R-HSA-5693532 DNA Double-Strand Break Repair 0.999719407802196 -0.000280631571160016 167 5 0.00514933058702369 971 10287 7468,79008,2070,8900,322 NSD2,SLX1B,EYA4,CCNA1,APBB1 R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.999788676034105 -0.000211346297950671 132 3 0.00308959835221421 971 10287 7468,79008,8900 NSD2,SLX1B,CCNA1 R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.999789058234968 -0.000210964016375227 85 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-5419276 Mitochondrial translation termination 0.999827302932665 -0.00017271198119036 87 1 0.00102986611740474 971 10287 29093 MRPL22 R-HSA-5368286 Mitochondrial translation initiation 0.999827302932665 -0.00017271198119036 87 1 0.00102986611740474 971 10287 29093 MRPL22 R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999834976172487 -0.000165037445443087 113 2 0.00205973223480947 971 10287 9481,4714 SLC25A27,NDUFB8 R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.999840968799712 -0.000159043847090633 322 14 0.0144181256436663 971 10287 2861,643,3363,3627,9170,64748,50865,8477,23596,153,5021,5028,7253,1131 GPR37,CXCR5,HTR7,CXCL10,LPAR2,PLPPR2,HEBP1,GPR65,OPN3,ADRB1,OXTR,P2RY1,TSHR,CHRM3 R-HSA-912446 Meiotic recombination 0.999843743013255 -0.000156269196139858 88 1 0.00102986611740474 971 10287 56154 TEX15 R-HSA-5389840 Mitochondrial translation elongation 0.999843743013255 -0.000156269196139858 88 1 0.00102986611740474 971 10287 29093 MRPL22 R-HSA-211000 Gene Silencing by RNA 0.999862838291535 -0.000137171115992279 137 3 0.00308959835221421 971 10287 192670,5903,11022 AGO4,RANBP2,TDRKH R-HSA-5693538 Homology Directed Repair 0.999874236808672 -0.000125771100181078 138 3 0.00308959835221421 971 10287 7468,79008,8900 NSD2,SLX1B,CCNA1 R-HSA-611105 Respiratory electron transport 0.99989528414249 -0.000104721340598017 92 1 0.00102986611740474 971 10287 4714 NDUFB8 R-HSA-69275 G2/M Transition 0.999913963353249 -8.6040348115929e-05 182 5 0.00514933058702369 971 10287 10382,5577,7846,8900,8945 TUBB4A,PRKAR2B,TUBA1A,CCNA1,BTRC R-HSA-5368287 Mitochondrial translation 0.999914281992397 -8.57216816017057e-05 94 1 0.00102986611740474 971 10287 29093 MRPL22 R-HSA-162906 HIV Infection 0.999917981023731 -8.20223400090979e-05 236 8 0.0082389289392379 971 10287 4869,5903,155382,6875,1794,8945,92421,2963 NPM1,RANBP2,VPS37D,TAF4B,DOCK2,BTRC,CHMP4C,GTF2F2 R-HSA-453279 Mitotic G1-G1/S phases 0.999918622187973 -8.13811233809665e-05 143 3 0.00308959835221421 971 10287 10000,4609,8900 AKT3,MYC,CCNA1 R-HSA-453274 Mitotic G2-G2/M phases 0.999926663069757 -7.33396195271917e-05 184 5 0.00514933058702369 971 10287 10382,5577,7846,8900,8945 TUBB4A,PRKAR2B,TUBA1A,CCNA1,BTRC R-HSA-388396 GPCR downstream signaling 0.999928793419219 -7.12091160898598e-05 974 61 0.062821833161689 971 10287 282763,643,6004,55970,9170,5153,9826,50865,8477,8601,79339,3709,2870,5028,6000,5578,57406,26230,55160,2838,26575,10846,23263,5580,65055,23596,112,5144,7253,343171,10125,1131,9846,11245,10451,79924,57580,26086,107,10203,84033,5151,5588,390442,23236,157,26084,2770,285601,3363,747,3627,391195,5579,10000,59345,5924,6001,153,5021,7222 OR51B5,CXCR5,RGS16,GNG12,LPAR2,PDE1B,ARHGEF11,HEBP1,GPR65,RGS20,OR51B4,ITPR2,GRK6,P2RY1,RGS7,PRKCA,ABHD6,TIAM2,ARHGEF10L,GPR15,RGS17,PDE10A,MCF2L,PRKCD,REEP1,OPN3,ADCY6,PDE4D,TSHR,OR2W3,RASGRP1,CHRM3,GAB2,GPR176,VAV3,ADM2,PREX1,GPSM1,ADCY1,CALCRL,OBSCN,PDE8A,PRKCQ,OR11H4,PLCB1,GRK3,ARHGEF26,GNAI1,GPR150,HTR7,DAGLA,CXCL10,OR2T33,PRKCB,AKT3,GNB4,RASGRF2,RGS10,ADRB1,OXTR,TRPC3 R-HSA-6803157 Antimicrobial peptides 0.99993652132071 -6.34806941470248e-05 97 1 0.00102986611740474 971 10287 475 ATOX1 R-HSA-375276 Peptide ligand-binding receptors 0.99994678902517 -5.3212390584493e-05 188 5 0.00514933058702369 971 10287 2861,643,3627,5021,50865 GPR37,CXCR5,CXCL10,OXTR,HEBP1 R-HSA-69239 Synthesis of DNA 0.999957475496508 -4.25254076843439e-05 101 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.999965196881324 -3.48037243181451e-05 103 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-69242 S Phase 0.999965835943349 -3.41646402554017e-05 130 2 0.00205973223480947 971 10287 4609,8900 MYC,CCNA1 R-HSA-5689603 UCH proteinases 0.999971517440991 -2.84829646451081e-05 105 1 0.00102986611740474 971 10287 7347 UCHL3 R-HSA-5578749 Transcriptional regulation by small RNAs 0.999974233668399 -2.57666635584164e-05 106 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.999978255541953 -2.1744694461401e-05 158 3 0.00308959835221421 971 10287 5163,9481,4714 PDK1,SLC25A27,NDUFB8 R-HSA-69306 DNA Replication 0.999980925798138 -1.9074383777223e-05 109 1 0.00102986611740474 971 10287 8900 CCNA1 R-HSA-69620 Cell Cycle Checkpoints 0.999981465484115 -1.85346876516618e-05 201 5 0.00514933058702369 971 10287 7468,57060,2810,8900,25946 NSD2,PCBP4,SFN,CCNA1,ZNF385A R-HSA-68877 Mitotic Prometaphase 0.999984391795751 -1.56083260584894e-05 111 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-2262752 Cellular responses to stress 0.999984862821215 -1.51372933531199e-05 451 20 0.0205973223480947 971 10287 5563,23043,3397,475,192670,116835,23710,9261,1051,9531,5903,6196,5608,8900,9474,5602,3306,58528,1911,92421 PRKAA2,TNIK,ID1,ATOX1,AGO4,HSPA12B,GABARAPL1,MAPKAPK2,CEBPB,BAG3,RANBP2,RPS6KA2,MAP2K6,CCNA1,ATG5,MAPK10,HSPA2,RRAGD,PHC1,CHMP4C R-HSA-5689880 Ub-specific processing proteases 0.99998532836406 -1.46717435700159e-05 223 6 0.00617919670442842 971 10287 2625,4088,9099,84749,4609,8900 GATA3,SMAD3,USP2,USP30,MYC,CCNA1 R-HSA-5696398 Nucleotide Excision Repair 0.999985881133576 -1.41189660958483e-05 112 1 0.00102986611740474 971 10287 2073 ERCC5 R-HSA-4839726 Chromatin organization 0.99998752092338 -1.24791544841552e-05 279 9 0.00926879505664264 971 10287 80853,64324,83852,10765,84159,7468,6604,64754,2122 KDM7A,NSD1,SETDB2,KDM5B,ARID5B,NSD2,SMARCD3,SMYD3,MECOM R-HSA-3247509 Chromatin modifying enzymes 0.99998752092338 -1.24791544841552e-05 279 9 0.00926879505664264 971 10287 80853,64324,83852,10765,84159,7468,6604,64754,2122 KDM7A,NSD1,SETDB2,KDM5B,ARID5B,NSD2,SMARCD3,SMYD3,MECOM R-HSA-69481 G2/M Checkpoints 0.999999134775377 -8.65224997018174e-07 169 2 0.00205973223480947 971 10287 7468,2810 NSD2,SFN R-HSA-5688426 Deubiquitination 0.999999407613337 -5.92386838498837e-07 301 8 0.0082389289392379 971 10287 4088,5071,9099,4609,8900,2625,84749,7347 SMAD3,PRKN,USP2,MYC,CCNA1,GATA3,USP30,UCHL3 R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.999999657131668 -3.42868390347493e-07 149 1 0.00102986611740474 971 10287 4774 NFIA R-HSA-73894 DNA Repair 0.999999820318515 -1.79681501053191e-07 316 8 0.0082389289392379 971 10287 8900,322,199990,7468,79008,2073,4255,2070 CCNA1,APBB1,FAAP20,NSD2,SLX1B,ERCC5,MGMT,EYA4 R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.99999994231594 -5.76840620144439e-08 247 4 0.00411946446961895 971 10287 5903,8563,84321,2963 RANBP2,THOC5,THOC3,GTF2F2 R-HSA-2467813 Separation of Sister Chromatids 0.999999949482913 -5.05170880953406e-08 168 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-68882 Mitotic Anaphase 0.999999983379128 -1.66208720887945e-08 179 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-2555396 Mitotic Metaphase and Anaphase 0.999999984971969 -1.50280311040876e-08 180 1 0.00102986611740474 971 10287 5903 RANBP2 R-HSA-72163 mRNA Splicing - Major Pathway 0.99999999260901 -7.39099030197701e-09 187 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-72172 mRNA Splicing 0.999999996708372 -3.29162812211995e-09 195 1 0.00102986611740474 971 10287 2963 GTF2F2 R-HSA-1640170 Cell Cycle 0.999999999392004 -6.07996279782808e-10 621 21 0.0216271884654995 971 10287 7846,7468,4869,5577,64900,55651,5578,10382,5903,56154,10388,5579,7015,57060,4609,10000,8900,3306,2810,8945,25946 TUBA1A,NSD2,NPM1,PRKAR2B,LPIN3,NHP2,PRKCA,TUBB4A,RANBP2,TEX15,SYCP2,PRKCB,TERT,PCBP4,MYC,AKT3,CCNA1,HSPA2,SFN,BTRC,ZNF385A R-HSA-68886 M Phase 0.9999999997768 -2.2320037357897e-10 308 4 0.00411946446961895 971 10287 5903,64900,5578,5579 RANBP2,LPIN3,PRKCA,PRKCB R-HSA-74160 Gene Expression 0.99999999982811 -1.71890361393124e-10 1821 103 0.106076210092688 971 10287 8563,134353,282890,4869,11022,55651,5578,85456,16,6497,79047,5366,604,55240,5452,51121,10794,64065,3486,6207,1787,2617,83667,2649,7039,4774,147929,665,10413,192670,26512,27244,148266,7453,4088,7552,5903,10781,90874,1978,10769,8900,25937,619279,27113,4306,4300,55762,84321,284252,58528,6224,833,5563,860,219749,221078,10644,7762,8794,23521,54541,6164,1938,6940,126070,4609,57060,6205,5580,27166,7020,2963,6446,9443,6228,25946,6154,9099,10765,3174,3164,2104,6144,100289635,6604,4141,639,900,6875,148206,148156,9261,6136,5325,6158,7761,10000,5608,6124,6206,2810,9310 THOC5,LSM11,ZNF311,NPM1,TDRKH,NHP2,PRKCA,TNKS1BP1,AARS,SKI,KCTD15,PMAIP1,BCL6,STEAP3,POU2F2,RPL26L1,ZNF460,PERP,IGFBP3,RPS13,TRDMT1,GARS,SESN2,NR6A1,TGFA,NFIA,ZNF565,BNIP3L,YAP1,AGO4,INTS6,SESN1,ZNF569,WARS,SMAD3,ZNF711,RANBP2,ZNF266,ZNF697,EIF4EBP1,PLK2,CCNA1,WWTR1,ZNF704,BBC3,NR3C2,MLLT3,ZNF701,THOC3,KCTD1,RRAGD,RPS20,CARS,PRKAA2,RUNX2,ZNF25,NSUN6,IGF2BP2,ZNF215,TNFRSF10C,RPL13A,DDIT4,RPL34,EEF2,ZNF354A,ZNF440,MYC,PCBP4,RPS11,PRKCD,PRELID1,TFAP2A,GTF2F2,SGK1,MED7,RPS23,ZNF385A,RPL26,USP2,KDM5B,HNF4G,NR4A1,ESRRG,RPL21,ZNF605,SMARCD3,MARS,PRDM1,CCNG1,TAF4B,ZNF714,ZNF558,MAPKAPK2,RPL12,PLAGL1,RPL28,ZNF214,AKT3,MAP2K6,RPL4,RPS12,SFN,ZNF235 R-HSA-69278 Cell Cycle, Mitotic 0.999999999956951 -4.30487750449144e-11 514 11 0.0113285272914521 971 10287 10382,5903,7846,5579,10000,4609,8900,5577,64900,5578,8945 TUBB4A,RANBP2,TUBA1A,PRKCB,AKT3,MYC,CCNA1,PRKAR2B,LPIN3,PRKCA,BTRC R-HSA-381753 Olfactory Signaling Pathway 0.999999999967705 -3.22954114248587e-11 391 6 0.00617919670442842 971 10287 282763,79339,391195,390442,343171,65055 OR51B5,OR51B4,OR2T33,OR11H4,OR2W3,REEP1 R-HSA-1482883 Acyl chain remodeling of DAG and TAG 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-68952 DNA replication initiation 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-6787450 tRNA modification in the mitochondrion 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-73928 Depyrimidination 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-110329 Cleavage of the damaged pyrimidine 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-804914 Transport of fatty acids 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-5576890 Phase 3 - rapid repolarisation 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-444821 Relaxin receptors 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-448424 Interleukin-17 signaling 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-174430 Telomere C-strand synthesis initiation 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-177128 Conjugation of salicylate with glycine 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-72731 Recycling of eIF2:GDP 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-2142789 Ubiquinol biosynthesis 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.999999999970936 -2.90643253700112e-11 8 0 0 971 10287 R-HSA-5602680 MyD88 deficiency (TLR5) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-265473 Trafficking of dietary sterols 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5653890 Lactose synthesis 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-8849472 PTK6 Down-Regulation 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-77108 Utilization of Ketone Bodies 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-111458 Formation of apoptosome 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-163282 Mitochondrial transcription initiation 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-193681 Ceramide signalling 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-198745 Signalling to STAT3 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-2395516 Electron transport from NADPH to Ferredoxin 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-844455 The NLRP1 inflammasome 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-177539 Autointegration results in viral DNA circles 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-111446 Activation of BIM and translocation to mitochondria 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5357572 Lysosomal glycogen catabolism 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-350864 Regulation of thyroid hormone activity 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-110331 Cleavage of the damaged purine 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1299503 TWIK related potassium channel (TREK) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-3249367 STAT6-mediated induction of chemokines 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-352238 Breakdown of the nuclear lamina 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1296067 Potassium transport channels 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-6806664 Metabolism of vitamin K 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-351200 Interconversion of polyamines 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-175567 Integration of viral DNA into host genomic DNA 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-3296197 Hydroxycarboxylic acid-binding receptors 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-217271 FMO oxidises nucleophiles 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-139910 Activation of BMF and translocation to mitochondria 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1483248 Synthesis of PIPs at the ER membrane 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-427589 Type II Na+/Pi cotransporters 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-73927 Depurination 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-444411 Rhesus glycoproteins mediate ammonium transport. 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-844615 The AIM2 inflammasome 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G) 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-165181 Inhibition of TSC complex formation by PKB 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-162699 Synthesis of dolichyl-phosphate mannose 0.999999999988386 -1.16135914903989e-11 3 0 0 971 10287 R-HSA-425561 Sodium/Calcium exchangers 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-211227 Activation of DNA fragmentation factor 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-350054 Notch-HLH transcription pathway 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-75205 Dissolution of Fibrin Clot 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-3270619 IRF3-mediated induction of type I IFN 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-2995383 Initiation of Nuclear Envelope Reformation 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-140342 Apoptosis induced DNA fragmentation 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-2995410 Nuclear Envelope Reassembly 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-202670 ERKs are inactivated 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-1663150 The activation of arylsulfatases 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-432047 Passive transport by Aquaporins 0.999999999995557 -4.44278752929631e-12 13 0 0 971 10287 R-HSA-5083630 Defective LFNG causes SCDO3 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-447115 Interleukin-12 signaling 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-8847453 Synthesis of PIPs in the nucleus 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-8849474 PTK6 Activates STAT3 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-173736 Alternative complement activation 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-204626 Hypusine synthesis from eIF5A-lysine 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-176034 Interactions of Tat with host cellular proteins 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-4551638 SUMOylation of chromatin organization proteins 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-1296061 HCN channels 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-2473224 Antagonism of Activin by Follistatin 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-5603037 IRAK4 deficiency (TLR5) 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-888593 Reuptake of GABA 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-427975 Proton/oligopeptide cotransporters 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-1855191 Synthesis of IPs in the nucleus 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-1369007 Mitochondrial ABC transporters 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-3000497 Scavenging by Class H Receptors 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-399710 Activation of AMPA receptors 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-209905 Catecholamine biosynthesis 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-209563 Axonal growth stimulation 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-417973 Adenosine P1 receptors 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-3878781 Glycogen storage disease type IV (GBE1) 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-428776 Class II GLUTs 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-173107 Binding and entry of HIV virion 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-75944 Transcription from mitochondrial promoters 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-1251932 PLCG1 events in ERBB2 signaling 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-442745 Activation of CaMK IV 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-8935690 Miscellaneous digestion events 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-1296025 ATP sensitive Potassium channels 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-390650 Histamine receptors 0.999999999996062 -3.93819636732191e-12 4 0 0 971 10287 R-HSA-70350 Fructose catabolism 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-5683678 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-71262 Carnitine synthesis 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-3642278 Loss of Function of TGFBR2 in Cancer 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-75157 FasL/ CD95L signaling 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-3000471 Scavenging by Class B Receptors 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-446205 Synthesis of GDP-mannose 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-1300652 Sperm:Oocyte Membrane Binding 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2161517 Abacavir transmembrane transport 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-444209 Free fatty acid receptors 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-1614517 Sulfide oxidation to sulfate 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2142850 Hyaluronan biosynthesis and export 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-70370 Galactose catabolism 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-8852405 Signaling by MST1 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-427652 Sodium-coupled phosphate cotransporters 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-390651 Dopamine receptors 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-1606341 IRF3 mediated activation of type 1 IFN 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-1306955 GRB7 events in ERBB2 signaling 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-71032 Propionyl-CoA catabolism 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-187024 NGF-independant TRKA activation 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111461 Cytochrome c-mediated apoptotic response 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-380095 Tachykinin receptors bind tachykinins 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-157881 Cyclin B2 mediated events 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-6785470 tRNA processing in the mitochondrion 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111463 SMAC binds to IAPs 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-561048 Organic anion transport 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-69478 G2/M DNA replication checkpoint 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-8866423 VLDL biosynthesis 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-391906 Leukotriene receptors 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-8849473 PTK6 Expression 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-209931 Serotonin and melatonin biosynthesis 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-111469 SMAC-mediated apoptotic response 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-5662702 Melanin biosynthesis 0.999999999996426 -3.57435332247718e-12 5 0 0 971 10287 R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-110312 Translesion synthesis by REV1 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-5218859 Regulated Necrosis 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-918233 TRAF3-dependent IRF activation pathway 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-1834941 STING mediated induction of host immune responses 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-5213460 RIPK1-mediated regulated necrosis 0.999999999996965 -3.03541968789713e-12 16 0 0 971 10287 R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-176412 Phosphorylation of the APC/C 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-110320 Translesion Synthesis by POLH 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-71403 Citric acid cycle (TCA cycle) 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-156584 Cytosolic sulfonation of small molecules 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.999999999998271 -1.72847167944715e-12 19 0 0 971 10287 R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-162594 Early Phase of HIV Life Cycle 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-209560 NF-kB is activated and signals survival 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-4839744 truncated APC mutants destabilize the destruction complex 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-69166 Removal of the Flap Intermediate 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-209543 p75NTR recruits signalling complexes 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-5675482 Regulation of necroptotic cell death 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-69091 Polymerase switching 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-4839748 AMER1 mutants destabilize the destruction complex 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-69109 Leading Strand Synthesis 0.999999999998794 -1.20605001197274e-12 14 0 0 971 10287 R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 1.00000000000187 1.87223405282922e-12 30 0 0 971 10287 R-HSA-5663084 Diseases of carbohydrate metabolism 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-428643 Organic anion transporters 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-8868766 rRNA processing in the mitochondrion 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-209968 Thyroxine biosynthesis 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-73929 Base-Excision Repair, AP Site Formation 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-193692 Regulated proteolysis of p75NTR 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-167590 Nef Mediated CD4 Down-regulation 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-3229121 Glycogen storage diseases 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-425381 Bicarbonate transporters 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-389887 Beta-oxidation of pristanoyl-CoA 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-430116 GP1b-IX-V activation signalling 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-110056 MAPK3 (ERK1) activation 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-3785653 Myoclonic epilepsy of Lafora 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-1300644 Interaction With The Zona Pellucida 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-427601 Multifunctional anion exchangers 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-727802 Transport of nucleotide sugars 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-190377 FGFR2b ligand binding and activation 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-937042 IRAK2 mediated activation of TAK1 complex 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-174437 Removal of the Flap Intermediate from the C-strand 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-2465910 MASTL Facilitates Mitotic Progression 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-201688 WNT mediated activation of DVL 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-8853334 Signaling by FGFR3 fusions in cancer 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-3215018 Processing and activation of SUMO 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-390450 Folding of actin by CCT/TriC 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-5687613 Diseases associated with surfactant metabolism 1.0000000000023 2.30144800048648e-12 10 0 0 971 10287 R-HSA-68881 Mitotic Metaphase/Anaphase Transition 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-205017 NFG and proNGF binds to p75NTR 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-1483152 Hydrolysis of LPE 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-168277 Influenza Virus Induced Apoptosis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-1483101 Synthesis of PS 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-177162 Conjugation of phenylacetate with glutamine 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5652227 Fructose biosynthesis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-141334 PAOs oxidise polyamines to amines 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-75102 C6 deamination of adenosine 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-844623 The IPAF inflammasome 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-71737 Pyrophosphate hydrolysis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-75064 mRNA Editing: A to I Conversion 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-156582 Acetylation 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-141424 Amplification of signal from the kinetochores 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-888568 GABA synthesis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-75896 Plasmalogen biosynthesis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-111457 Release of apoptotic factors from the mitochondria 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-165160 PDE3B signalling 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359478 Defective MUT causes methylmalonic aciduria mut type 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5357609 Glycogen storage disease type II (GAA) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-198765 Signalling to ERK5 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-351143 Agmatine biosynthesis 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-70688 Proline catabolism 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359475 Defective MMAA causes methylmalonic aciduria type cblA 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-8942233 Intestinal infectious diseases 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-114294 Activation, translocation and oligomerization of BAX 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-211736 Stimulation of the cell death response by PAK-2p34 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-187042 TRKA activation by NGF 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-166020 Transfer of LPS from LBP carrier to CD14 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3814836 Glycogen storage disease type XV (GYG1) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359485 Defective CD320 causes methylmalonic aciduria 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-8854521 Interaction between PHLDA1 and AURKA 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5619107 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-77042 Formation of editosomes by ADAR proteins 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-3858516 Glycogen storage disease type 0 (liver GYS2) 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-111452 Activation and oligomerization of BAK protein 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 1.00000000000273 2.73093526959034e-12 2 0 0 971 10287 R-HSA-182218 Nef Mediated CD8 Down-regulation 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-3656225 Defective CHST6 causes MCDC1 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-5652084 Fructose metabolism 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-447038 NrCAM interactions 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-111471 Apoptotic factor-mediated response 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-75158 TRAIL signaling 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-196791 Vitamin D (calciferol) metabolism 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-174362 Transport and synthesis of PAPS 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-5619102 SLC transporter disorders 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-420597 Nectin/Necl trans heterodimerization 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-448706 Interleukin-1 processing 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-433692 Proton-coupled monocarboxylate transport 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-164843 2-LTR circle formation 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 1.00000000000355 3.55255625178479e-12 7 0 0 971 10287 R-HSA-5661231 Metallothioneins bind metals 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-71182 Phenylalanine and tyrosine catabolism 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-196780 Biotin transport and metabolism 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-75072 mRNA Editing 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-2485179 Activation of the phototransduction cascade 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-68689 CDC6 association with the ORC:origin complex 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-3371378 Regulation by c-FLIP 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-1980148 Signaling by NOTCH3 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-5218900 CASP8 activity is inhibited 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-2470946 Cohesin Loading onto Chromatin 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-174414 Processive synthesis on the C-strand of the telomere 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-1059683 Interleukin-6 signaling 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-5660526 Response to metal ions 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-3296469 Defects in cobalamin (B12) metabolism 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-211999 CYP2E1 reactions 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-69416 Dimerization of procaspase-8 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-2514853 Condensation of Prometaphase Chromosomes 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-1980150 Signaling by NOTCH4 1.00000000000369 3.68613101295999e-12 11 0 0 971 10287 R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-500753 Pyrimidine biosynthesis 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-6787639 GDP-fucose biosynthesis 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-6793080 rRNA modification in the mitochondrion 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-193144 Estrogen biosynthesis 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-3323169 Defects in biotin (Btn) metabolism 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5660668 CLEC7A/inflammasome pathway 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-390247 Beta-oxidation of very long chain fatty acids 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-176417 Phosphorylation of Emi1 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-1237112 Methionine salvage pathway 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-193993 Mineralocorticoid biosynthesis 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5693548 Sensing of DNA Double Strand Breaks 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5579029 Metabolic disorders of biological oxidation enzymes 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-68616 Assembly of the ORC complex at the origin of replication 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-8849470 PTK6 Regulates Cell Cycle 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-187015 Activation of TRKA receptors 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-3065679 SUMO is proteolytically processed 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-2187335 The retinoid cycle in cones (daylight vision) 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-442717 CREB phosphorylation through the activation of CaMKK 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-177135 Conjugation of benzoate with glycine 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-428808 Na+-dependent glucose transporters 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-166662 Lectin pathway of complement activation 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5624138 Trafficking of myristoylated proteins to the cilium 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-6798163 Choline catabolism 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-5674499 Negative feedback regulation of MAPK pathway 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-6799990 Metal sequestration by antimicrobial proteins 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-3000484 Scavenging by Class F Receptors 1.00000000000386 3.85603562558206e-12 6 0 0 971 10287 R-HSA-68874 M/G1 Transition 1.00000000000532 5.31615160530653e-12 86 0 0 971 10287 R-HSA-69002 DNA Replication Pre-Initiation 1.00000000000532 5.31615160530653e-12 86 0 0 971 10287 R-HSA-194002 Glucocorticoid biosynthesis 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-156587 Amino Acid conjugation 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-391908 Prostanoid ligand receptors 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-110357 Displacement of DNA glycosylase by APEX1 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-162592 Integration of provirus 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-8854691 Interleukin-19, 20, 22, 24 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-1300642 Sperm Motility And Taxes 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-166665 Terminal pathway of complement 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-2474795 Diseases associated with visual transduction 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-112411 MAPK1 (ERK2) activation 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-189085 Digestion of dietary carbohydrate 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-2453864 Retinoid cycle disease events 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-75094 Formation of the Editosome 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-193697 p75NTR regulates axonogenesis 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-159424 Conjugation of carboxylic acids 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-196025 Formation of annular gap junctions 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-71336 Pentose phosphate pathway (hexose monophosphate shunt) 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-72200 mRNA Editing: C to U Conversion 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-1462054 Alpha-defensins 1.00000000000583 5.82566233849705e-12 9 0 0 971 10287 R-HSA-73772 RNA Polymerase I Promoter Escape 1.00000000000613 6.12966279100407e-12 31 0 0 971 10287 R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 1.0000000000063 6.29667752758523e-12 22 0 0 971 10287 R-HSA-77595 Processing of Intronless Pre-mRNAs 1.0000000000063 6.29667752758523e-12 22 0 0 971 10287 R-HSA-5620916 VxPx cargo-targeting to cilium 1.0000000000063 6.29667752758523e-12 22 0 0 971 10287 R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-6809583 Retinoid metabolism disease events 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1222499 Response of Mtb to phagocytosis 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-389542 NADPH regeneration 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-112122 ALKBH2 mediated reversal of alkylation damage 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1299344 TWIK-related spinal cord K+ channel (TRESK) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-163316 Mitochondrial transcription termination 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2534343 Interaction With Cumulus Cells 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-3248023 Regulation by TREX1 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1222352 Latent infection of Homo sapiens with Mycobacterium tuberculosis 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-169131 Inhibition of PKR 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1855231 Synthesis of IPs in the ER lumen 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-162589 Reverse Transcription of HIV RNA 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1483076 Synthesis of CL 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-171286 Synthesis and processing of ENV and VPU 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-3359474 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-140180 COX reactions 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-8853333 Signaling by FGFR2 fusions 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-162585 Uncoating of the HIV Virion 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-164525 Plus-strand DNA synthesis 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5263617 Metabolism of ingested MeSeO2H into MeSeH 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-164516 Minus-strand DNA synthesis 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5250982 Toxicity of tetanus toxin (TeNT) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2023837 Signaling by FGFR2 amplification mutants 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2466712 Biosynthesis of A2E, implicated in retinal degradation 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1222449 Mtb iron assimilation by chelation 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1300645 Acrosome Reaction 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2408552 Methylation of MeSeH for excretion 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-3359457 Defective GIF causes intrinsic factor deficiency 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-975574 Reactions specific to the hybrid N-glycan synthesis pathway 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-1483196 PI and PC transport between ER and Golgi membranes 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-2033515 t(4;14) translocations of FGFR3 1.0000000000068 6.80365486172008e-12 1 0 0 971 10287 R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 1.00000000000722 7.22320523157875e-12 60 0 0 971 10287 R-HSA-5387390 Hh mutants abrogate ligand secretion 1.00000000000722 7.22320523157875e-12 60 0 0 971 10287 R-HSA-3322077 Glycogen synthesis 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-68884 Mitotic Telophase/Cytokinesis 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-391903 Eicosanoid ligand-binding receptors 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-205043 NRIF signals cell death from the nucleus 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-69298 Association of licensing factors with the pre-replicative complex 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-5358508 Mismatch Repair 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-69183 Processive synthesis on the lagging strand 1.00000000000879 8.78678091750996e-12 15 0 0 971 10287 R-HSA-209776 Amine-derived hormones 1.00000000000885 8.85433471785828e-12 18 0 0 971 10287 R-HSA-1912420 Pre-NOTCH Processing in Golgi 1.00000000000885 8.85433471785828e-12 18 0 0 971 10287 R-HSA-73780 RNA Polymerase III Chain Elongation 1.00000000000885 8.85433471785828e-12 18 0 0 971 10287 R-HSA-5656169 Termination of translesion DNA synthesis 1.00000000000928 9.27851955962815e-12 34 0 0 971 10287 R-HSA-2160916 Hyaluronan uptake and degradation 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-3371511 HSF1 activation 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-2022857 Keratan sulfate degradation 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-2468052 Establishment of Sister Chromatid Cohesion 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-1296346 Tandem pore domain potassium channels 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-176974 Unwinding of DNA 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-211979 Eicosanoids 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 1.0000000000108 1.08001184468737e-11 12 0 0 971 10287 R-HSA-427359 SIRT1 negatively regulates rRNA Expression 1.00000000001118 1.11754092915768e-11 69 0 0 971 10287 R-HSA-68867 Assembly of the pre-replicative complex 1.00000000001118 1.11754092915768e-11 69 0 0 971 10287 R-HSA-5619084 ABC transporter disorders 1.00000000001118 1.11754092915768e-11 69 0 0 971 10287 R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 1.00000000001364 1.36362118429397e-11 28 0 0 971 10287 R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 1.00000000001364 1.36362118429397e-11 28 0 0 971 10287 R-HSA-1474165 Reproduction 1.0000000000145 1.44989337837761e-11 26 0 0 971 10287 R-HSA-1187000 Fertilization 1.0000000000145 1.44989337837761e-11 26 0 0 971 10287 R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 1.00000000001464 1.46359021660191e-11 67 0 0 971 10287 R-HSA-70895 Branched-chain amino acid catabolism 1.00000000001603 1.60329577352596e-11 24 0 0 971 10287 R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1.00000000001603 1.60329577352596e-11 24 0 0 971 10287 R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 1.00000000001603 1.60329577352596e-11 24 0 0 971 10287 R-HSA-69190 DNA strand elongation 1.0000000000165 1.64959991439968e-11 32 0 0 971 10287 R-HSA-68962 Activation of the pre-replicative complex 1.0000000000165 1.64959991439968e-11 32 0 0 971 10287 R-HSA-73863 RNA Polymerase I Transcription Termination 1.0000000000165 1.64959991439968e-11 32 0 0 971 10287 R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 1.00000000001658 1.65832352796431e-11 41 0 0 971 10287 R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.00000000001701 1.70080024716389e-11 43 0 0 971 10287 R-HSA-73933 Resolution of Abasic Sites (AP sites) 1.00000000001736 1.7360280768532e-11 37 0 0 971 10287 R-HSA-73884 Base Excision Repair 1.00000000001736 1.7360280768532e-11 37 0 0 971 10287 R-HSA-5689896 Ovarian tumor domain proteases 1.00000000001736 1.7360280768532e-11 37 0 0 971 10287 R-HSA-176187 Activation of ATR in response to replication stress 1.00000000001736 1.7360280768532e-11 37 0 0 971 10287 R-HSA-5673000 RAF activation 1.00000000001766 1.76554589516325e-11 25 0 0 971 10287 R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 1.00000000001766 1.76554589516325e-11 25 0 0 971 10287 R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 1.00000000001766 1.76554589516325e-11 25 0 0 971 10287 R-HSA-5668914 Diseases of metabolism 1.00000000001784 1.78399064403754e-11 44 0 0 971 10287 R-HSA-427413 NoRC negatively regulates rRNA expression 1.00000000001809 1.8094820536295e-11 107 0 0 971 10287 R-HSA-69618 Mitotic Spindle Checkpoint 1.00000000001835 1.83504098417447e-11 21 0 0 971 10287 R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.00000000001835 1.83504098417447e-11 21 0 0 971 10287 R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 1.00000000001835 1.83504098417447e-11 21 0 0 971 10287 R-HSA-73893 DNA Damage Bypass 1.00000000001915 1.91454505444731e-11 50 0 0 971 10287 R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 1.0000000000196 1.96027153902737e-11 27 0 0 971 10287 R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 1.0000000000196 1.96027153902737e-11 27 0 0 971 10287 R-HSA-400508 Incretin synthesis, secretion, and inactivation 1.00000000002079 2.07948993616752e-11 23 0 0 971 10287 R-HSA-8863678 Neurodegenerative Diseases 1.00000000002079 2.07948993616752e-11 23 0 0 971 10287 R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 1.00000000002079 2.07948993616752e-11 23 0 0 971 10287 R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 1.00000000002079 2.07948993616752e-11 23 0 0 971 10287 R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 1.00000000002081 2.08062519625987e-11 73 0 0 971 10287 R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 1.00000000002081 2.08136943338598e-11 52 0 0 971 10287 R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 1.00000000002081 2.08136943338598e-11 52 0 0 971 10287 R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 1.00000000002081 2.08136943338598e-11 52 0 0 971 10287 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 1.00000000002081 2.08136943338598e-11 52 0 0 971 10287 R-HSA-5656121 Translesion synthesis by POLI 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-193639 p75NTR signals via NF-kB 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5655862 Translesion synthesis by POLK 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-156711 Polo-like kinase mediated events 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5627117 RHO GTPases Activate ROCKs 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5625900 RHO GTPases activate CIT 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-196299 Beta-catenin phosphorylation cascade 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-2142845 Hyaluronan metabolism 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-192456 Digestion of dietary lipid 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-3296482 Defects in vitamin and cofactor metabolism 1.00000000002113 2.11254793309697e-11 17 0 0 971 10287 R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 1.00000000002121 2.12102503205314e-11 56 0 0 971 10287 R-HSA-4641257 Degradation of AXIN 1.00000000002121 2.12102503205314e-11 56 0 0 971 10287 R-HSA-69541 Stabilization of p53 1.00000000002121 2.12102503205314e-11 56 0 0 971 10287 R-HSA-933541 TRAF6 mediated IRF7 activation 1.00000000002144 2.14374096451412e-11 35 0 0 971 10287 R-HSA-2262749 Cellular response to hypoxia 1.00000000002171 2.17057176479165e-11 77 0 0 971 10287 R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 1.00000000002171 2.17057176479165e-11 77 0 0 971 10287 R-HSA-73762 RNA Polymerase I Transcription Initiation 1.00000000002199 2.19872602607425e-11 48 0 0 971 10287 R-HSA-212165 Epigenetic regulation of gene expression 1.00000000002212 2.21153827038729e-11 151 0 0 971 10287 R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.00000000002271 2.27105442047221e-11 61 0 0 971 10287 R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 1.00000000002276 2.27600427048611e-11 39 0 0 971 10287 R-HSA-5696394 DNA Damage Recognition in GG-NER 1.00000000002276 2.27600427048611e-11 39 0 0 971 10287 R-HSA-69236 G1 Phase 1.00000000002276 2.27600427048611e-11 39 0 0 971 10287 R-HSA-69231 Cyclin D associated events in G1 1.00000000002276 2.27600427048611e-11 39 0 0 971 10287 R-HSA-76046 RNA Polymerase III Transcription Initiation 1.00000000002282 2.28192287618714e-11 36 0 0 971 10287 R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-6804760 Regulation of TP53 Activity through Methylation 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-69186 Lagging Strand Synthesis 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-1643713 Signaling by EGFR in Cancer 1.00000000002286 2.28632630644113e-11 20 0 0 971 10287 R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.00000000002323 2.32277127162986e-11 110 0 0 971 10287 R-HSA-73854 RNA Polymerase I Promoter Clearance 1.00000000002323 2.32277127162986e-11 110 0 0 971 10287 R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.00000000002332 2.33199194778772e-11 57 0 0 971 10287 R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 1.00000000002346 2.34632122883004e-11 64 0 0 971 10287 R-HSA-73728 RNA Polymerase I Promoter Opening 1.00000000002348 2.3476675061744e-11 63 0 0 971 10287 R-HSA-3214847 HATs acetylate histones 1.00000000002375 2.37470006665702e-11 143 0 0 971 10287 R-HSA-212300 PRC2 methylates histones and DNA 1.00000000002499 2.49941333415965e-11 74 0 0 971 10287 R-HSA-2299718 Condensation of Prophase Chromosomes 1.00000000002499 2.49941333415965e-11 74 0 0 971 10287 R-HSA-1461957 Beta defensins 1.00000000002573 2.57311077390596e-11 42 0 0 971 10287 R-HSA-169911 Regulation of Apoptosis 1.00000000002643 2.64258071472805e-11 54 0 0 971 10287 R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 1.00000000002643 2.64258071472805e-11 54 0 0 971 10287 R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1.00000000002643 2.64258071472805e-11 54 0 0 971 10287 R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 1.00000000002643 2.64258071472805e-11 54 0 0 971 10287 R-HSA-69610 p53-Independent DNA Damage Response 1.00000000002643 2.64258071472805e-11 54 0 0 971 10287 R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.00000000002693 2.6925546005733e-11 53 0 0 971 10287 R-HSA-5250924 B-WICH complex positively regulates rRNA expression 1.00000000002769 2.76870471500791e-11 93 0 0 971 10287 R-HSA-73864 RNA Polymerase I Transcription 1.00000000002775 2.7749582785647e-11 112 0 0 971 10287 R-HSA-73777 RNA Polymerase I Chain Elongation 1.00000000002805 2.80471478501144e-11 91 0 0 971 10287 R-HSA-3214815 HDACs deacetylate histones 1.00000000002807 2.80694513980807e-11 94 0 0 971 10287 R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 1.00000000002895 2.89537579304109e-11 58 0 0 971 10287 R-HSA-1461973 Defensins 1.00000000002961 2.9613036532527e-11 51 0 0 971 10287 R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 1.00000000002961 2.9613036532527e-11 51 0 0 971 10287 R-HSA-171306 Packaging Of Telomere Ends 1.00000000002961 2.9613036532527e-11 51 0 0 971 10287 R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.00000000002963 2.96271724868012e-11 40 0 0 971 10287 R-HSA-180585 Vif-mediated degradation of APOBEC3G 1.00000000002998 2.99814512229926e-11 55 0 0 971 10287 R-HSA-5334118 DNA methylation 1.00000000003357 3.35740513929941e-11 65 0 0 971 10287 R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 1.00000000003357 3.35740513929941e-11 65 0 0 971 10287 R-HSA-5678895 Defective CFTR causes cystic fibrosis 1.00000000003456 3.45585117698069e-11 62 0 0 971 10287 R-HSA-5250913 Positive epigenetic regulation of rRNA expression 1.00000000003508 3.50818874089715e-11 108 0 0 971 10287 R-HSA-5619115 Disorders of transmembrane transporters 1.00000000003627 3.62732956338087e-11 76 0 0 971 10287 R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 1.00000000003627 3.62732956338087e-11 76 0 0 971 10287 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.00000000003736 3.73616043165347e-11 68 0 0 971 10287 R-HSA-5689901 Metalloprotease DUBs 1.00000000004051 4.05102715143585e-11 38 0 0 971 10287 R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.00000000004051 4.05102715143585e-11 38 0 0 971 10287