TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols WP197 Cholesterol Biosynthesis 4.82860818675633e-06 -12.2409522919177 15 9 0.015817223198594 569 5312 1595,3157,3422,4598,6307,4597,6713,1717,3156 CYP51A1,HMGCS1,IDI1,MVK,MSMO1,MVD,SQLE,DHCR7,HMGCR WP2857 Mesodermal Commitment Pathway 0.00042904598636748 -7.75394645045137 156 31 0.054481546572935 569 5312 57669,10451,90,659,8322,8325,11166,84159,10413,2625,7546,1488,93,27244,2260,22943,4088,23576,83439,8320,85416,6001,92,154091,9760,688,657,652,4091,3169,1466 EPB41L5,VAV3,ACVR1,BMPR2,FZD4,FZD8,SOX21,ARID5B,YAP1,GATA3,ZIC2,CTBP2,ACVR2B,SESN1,FGFR1,DKK1,SMAD3,DDAH1,TCF7L1,EOMES,ZIC5,RGS10,ACVR2A,SLC2A12,TOX,KLF5,BMPR1A,BMP4,SMAD6,FOXA1,CSRP2 WP3613 Photodynamic therapy-induced unfolded protein response 0.00055490478883527 -7.49671401058267 29 10 0.0175746924428823 569 5312 57761,468,440,5611,2081,7494,27113,467,1649,7453 TRIB3,ATF4,ASNS,DNAJC3,ERN1,XBP1,BBC3,ATF3,DDIT3,WARS WP3850 Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling 0.00100801130946392 -6.89977588968963 31 10 0.0175746924428823 569 5312 4088,114907,3480,5163,2660,7132,93,5337,10891,4703 SMAD3,FBXO32,IGF1R,PDK1,MSTN,TNFRSF1A,ACVR2B,PLD1,PPARGC1A,NEB WP536 Calcium Regulation in the Cardiac Cell 0.0011555563674341 -6.76317334758408 151 29 0.0509666080843585 569 5312 6004,55970,777,2706,107,8601,6262,5588,5577,3709,481,2870,6000,5578,10052,2770,26575,5579,59345,2775,5580,6001,153,112,5569,490,2810,5567,1131 RGS16,GNG12,CACNA1E,GJB2,ADCY1,RGS20,RYR2,PRKCQ,PRKAR2B,ITPR2,ATP1B1,GRK6,RGS7,PRKCA,GJC1,GNAI1,RGS17,PRKCB,GNB4,GNAO1,PRKCD,RGS10,ADRB1,ADCY6,PKIA,ATP2B1,SFN,PRKACB,CHRM3 WP3859 TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 0.00172353681778418 -6.36337681001667 18 7 0.0123022847100176 569 5312 4088,7431,3397,860,2335,1000,6591 SMAD3,VIM,ID1,RUNX2,FN1,CDH2,SNAI2 WP289 Myometrial Relaxation and Contraction Pathways 0.00238577789480028 -6.03823004647904 158 29 0.0509666080843585 569 5312 6004,55970,468,3489,107,8601,6262,9446,5588,467,5577,2870,3709,6000,5578,26575,5579,59345,5580,6001,59,112,5021,5144,5569,5567,2810,3486,4846 RGS16,GNG12,ATF4,IGFBP6,ADCY1,RGS20,RYR2,GSTO1,PRKCQ,ATF3,PRKAR2B,GRK6,ITPR2,RGS7,PRKCA,RGS17,PRKCB,GNB4,PRKCD,RGS10,ACTA2,ADCY6,OXTR,PDE4D,PKIA,PRKACB,SFN,IGFBP3,NOS3 WP2011 SREBF and miR33 in cholesterol and lipid homeostasis 0.00248045750826585 -5.99931225667997 19 7 0.0123022847100176 569 5312 6319,3157,10891,3949,2194,3156,6720 SCD,HMGCS1,PPARGC1A,LDLR,FASN,HMGCR,SREBF1 WP236 Adipogenesis 0.0027099878807203 -5.91081111615946 131 25 0.0439367311072056 569 5312 2625,6777,1050,6319,64900,1592,1051,1879,8660,4088,3399,57761,2624,25937,649,6720,688,652,5106,10891,3977,1649,1052,4208,8321 GATA3,STAT5B,CEBPA,SCD,LPIN3,CYP26A1,CEBPB,EBF1,IRS2,SMAD3,ID3,TRIB3,GATA2,WWTR1,BMP1,SREBF1,KLF5,BMP4,PCK2,PPARGC1A,LIFR,DDIT3,CEBPD,MEF2C,FZD1 WP2858 Ectoderm Differentiation 0.00448099452204954 -5.4079102656628 143 26 0.0456942003514939 569 5312 10257,60401,6785,8322,5783,8325,10486,5362,2274,8495,9935,51222,1496,57462,25987,6622,83439,1896,4609,7020,8848,657,652,5452,10253,1501 ABCC4,EDA2R,ELOVL4,FZD4,PTPN13,FZD8,CAP2,PLXNA2,FHL2,PPFIBP2,MAFB,ZNF219,CTNNA2,MYORG,TSKU,SNCA,TCF7L1,EDA,MYC,TFAP2A,TSC22D1,BMPR1A,BMP4,POU2F2,SPRY2,CTNND2 WP481 Insulin Signaling 0.00616900207936139 -5.08821819168849 161 28 0.0492091388400703 569 5312 5563,10580,23433,3636,2888,9265,5588,5596,6616,5578,10110,8660,57761,5167,6196,3480,5579,5608,1978,7494,5580,23678,6446,5603,2887,9882,5602,6812 PRKAA2,SORBS1,RHOQ,INPPL1,GRB14,CYTH3,PRKCQ,MAPK4,SNAP25,PRKCA,SGK2,IRS2,TRIB3,ENPP1,RPS6KA2,IGF1R,PRKCB,MAP2K6,EIF4EBP1,XBP1,PRKCD,SGK3,SGK1,MAPK13,GRB10,TBC1D4,MAPK10,STXBP1 WP474 Endochondral Ossification 0.00771973372309198 -4.86397540736777 65 14 0.0246045694200351 569 5312 5167,3157,860,3480,579,1515,2690,6777,657,871,654,2260,4208,85477 ENPP1,HMGCS1,RUNX2,IGF1R,NKX3-2,CTSV,GHR,STAT5B,BMPR1A,SERPINH1,BMP6,FGFR1,MEF2C,SCIN WP3679 Cell-type Dependent Selectivity of CCK2R Signaling 0.00857143825823557 -4.75931973568851 13 5 0.00878734622144113 569 5312 7220,747,6262,23236,2770 TRPC1,DAGLA,RYR2,PLCB1,GNAI1 WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy 0.0134215676539817 -4.31089233950818 76 15 0.0263620386643234 569 5312 83439,3695,10368,783,3655,1829,3673,3690,6262,5318,1000,1832,785,781,1496 TCF7L1,ITGB7,CACNG3,CACNB2,ITGA6,DSG2,ITGA2,ITGB3,RYR2,PKP2,CDH2,DSP,CACNB4,CACNA2D1,CTNNA2 WP2853 Endoderm Differentiation 0.0192534223628553 -3.95006644896684 145 24 0.0421792618629174 569 5312 57669,10451,1112,11166,23286,1488,23682,6875,27244,3198,22943,4088,23576,83439,8320,85416,6001,51460,9760,154091,5083,657,3169,7080 EPB41L5,VAV3,FOXN3,SOX21,WWC1,CTBP2,RAB38,TAF4B,SESN1,HOXA1,DKK1,SMAD3,DDAH1,TCF7L1,EOMES,ZIC5,RGS10,SFMBT1,TOX,SLC2A12,PAX9,BMPR1A,FOXA1,NKX2-1 WP3599 Transcription factor regulation in adipogenesis 0.0245542603981036 -3.70686990016025 22 6 0.0105448154657293 569 5312 1051,8660,1050,5106,10891,1052 CEBPB,IRS2,CEBPA,PCK2,PPARGC1A,CEBPD WP3874 Canonical and Non-Canonical TGF-B signaling 0.0287421766652215 -3.54938966476135 17 5 0.00878734622144113 569 5312 4088,657,84171,659,649 SMAD3,BMPR1A,LOXL4,BMPR2,BMP1 WP3584 MECP2 and Associated Rett Syndrome 0.0293886478500782 -3.5271468067523 62 12 0.0210896309314587 569 5312 627,114787,1750,4354,2894,604,6446,2570,4661,1052,26084,4208 BDNF,GPRIN1,DLX6,MPP1,GRID1,BCL6,SGK1,GABRR2,MYT1,CEBPD,ARHGEF26,MEF2C WP1425 Bone Morphogenic Protein (BMP) Signalling and Regulation 0.0319960445179247 -3.44214299263746 12 4 0.0070298769771529 569 5312 860,657,659,4091 RUNX2,BMPR1A,BMPR2,SMAD6 WP428 Wnt Signaling Pathway 0.0326838980126322 -3.4208727378711 70 13 0.0228471001757469 569 5312 5579,8325,4609,5580,3949,4040,7481,5588,4919,5578,5602,83999,8321 PRKCB,FZD8,MYC,PRKCD,LDLR,LRP6,WNT11,PRKCQ,ROR1,PRKCA,MAPK10,KREMEN1,FZD1 WP2012 miRs in Muscle Cell Differentiation 0.0333270048671121 -3.40138725367334 36 8 0.0140597539543058 569 5312 5579,5580,100271849,5577,5588,5578,5567,4208 PRKCB,PRKCD,MEF2B,PRKAR2B,PRKCQ,PRKCA,PRKACB,MEF2C WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling 0.0442288073736328 -3.11837895166095 73 13 0.0228471001757469 569 5312 5563,1595,3422,3157,3638,9871,4597,3949,2194,6720,6713,6319,3156 PRKAA2,CYP51A1,IDI1,HMGCS1,INSIG1,SEC24D,MVD,LDLR,FASN,SREBF1,SQLE,SCD,HMGCR WP2895 Differentiation of white and brown adipocyte 0.0442906635922681 -3.11698137826769 25 6 0.0105448154657293 569 5312 1051,1050,652,10891,4093,7545 CEBPB,CEBPA,BMP4,PPARGC1A,SMAD9,ZIC1 WP185 Integrin-mediated Cell Adhesion 0.0453086833093354 -3.09425658032949 103 17 0.0298769771528998 569 5312 5058,10451,3695,5829,10580,1793,3655,726,7145,5596,6414,5881,5608,10000,3690,3673,5602 PAK1,VAV3,ITGB7,PXN,SORBS1,DOCK1,ITGA6,CAPN5,TNS1,MAPK4,SELENOP,RAC3,MAP2K6,AKT3,ITGB3,ITGA2,MAPK10 WP3407 FTO Obesity Variant Mechanism 0.0453848957230811 -3.09257592261374 8 3 0.00527240773286467 569 5312 10265,10891,84159 IRX5,PPARGC1A,ARID5B WP1589 Folate-Alcohol and Cancer Pathway 0.0453848957230811 -3.09257592261374 8 3 0.00527240773286467 569 5312 1051,875,10840 CEBPB,CBS,ALDH1L1 WP2485 NAD Biosynthesis II (from tryptophan) 0.0453848957230811 -3.09257592261374 8 3 0.00527240773286467 569 5312 6999,8564,23475 TDO2,KMO,QPRT WP35 G Protein Signaling Pathways 0.0473565676711554 -3.05004976419242 96 16 0.0281195079086116 569 5312 55970,5153,5579,9495,9465,2775,5580,107,112,5588,5577,5151,5144,5578,5567,2770 GNG12,PDE1B,PRKCB,AKAP5,AKAP7,GNAO1,PRKCD,ADCY1,ADCY6,PRKCQ,PRKAR2B,PDE8A,PDE4D,PRKCA,PRKACB,GNAI1 WP23 B Cell Receptor Signaling Pathway 0.0555648424598058 -2.89020460759005 98 16 0.0281195079086116 569 5312 6452,5966,5777,1380,5596,1147,5788,118788,5579,4609,5608,5580,604,6850,9846,4208 SH3BP2,REL,PTPN6,CR2,MAPK4,CHUK,PTPRC,PIK3AP1,PRKCB,MYC,MAP2K6,PRKCD,BCL6,SYK,GAB2,MEF2C WP399 Wnt Signaling Pathway and Pluripotency 0.0570709983988554 -2.86345920030136 106 17 0.0298769771528998 569 5312 8322,8325,120892,3949,5588,1488,7481,5578,5523,83439,5579,4609,5580,4040,5521,5602,8321 FZD4,FZD8,LRRK2,LDLR,PRKCQ,CTBP2,WNT11,PRKCA,PPP2R3A,TCF7L1,PRKCB,MYC,PRKCD,LRP6,PPP2R2B,MAPK10,FZD1 WP437 EGF/EGFR Signaling Pathway 0.0610149041083555 -2.79663711500728 162 24 0.0421792618629174 569 5312 5058,10451,10188,3636,9047,2059,5596,6777,5578,4734,6196,6456,5579,1978,5580,2887,5287,5337,54206,6812,10253,4846,4208,9846 PAK1,VAV3,TNK2,INPPL1,SH2D2A,EPS8,MAPK4,STAT5B,PRKCA,NEDD4,RPS6KA2,SH3GL2,PRKCB,EIF4EBP1,PRKCD,GRB10,PIK3C2B,PLD1,ERRFI1,STXBP1,SPRY2,NOS3,MEF2C,GAB2 WP51 Regulation of Actin Cytoskeleton 0.0727735783065565 -2.62040232500597 149 22 0.0386643233743409 569 5312 2264,5058,54961,55970,5829,2335,2258,57144,1793,2257,5596,55740,8822,5881,2260,10458,2934,138429,5287,22800,5159,1131 FGFR4,PAK1,SSH3,GNG12,PXN,FN1,FGF13,PAK5,DOCK1,FGF12,MAPK4,ENAH,FGF17,RAC3,FGFR1,BAIAP2,GSN,PIP5KL1,PIK3C2B,RRAS2,PDGFRB,CHRM3 WP1424 Globo Sphingolipid Metabolism 0.0785171418311665 -2.54443831075643 22 5 0.00878734622144113 569 5312 256435,26301,6489,10690,6480 ST6GALNAC3,GBGT1,ST8SIA1,FUT9,ST6GAL1 WP2884 NRF2 pathway 0.0818850054010156 -2.50243938912176 143 21 0.0369068541300527 569 5312 2042,6536,2946,10257,2258,64116,2948,4259,7039,645,1244,114134,114112,23516,23657,11182,2947,3082,55117,154091,23491 EPHA3,SLC6A9,GSTM2,ABCC4,FGF13,SLC39A8,GSTM4,MGST3,TGFA,BLVRB,ABCC2,SLC2A13,TXNRD3,SLC39A14,SLC7A11,SLC2A6,GSTM3,HGF,SLC6A15,SLC2A12,CES3 WP2874 Liver X Receptor Pathway 0.0827874679494628 -2.49147858231334 10 3 0.00527240773286467 569 5312 6319,2194,6720 SCD,FASN,SREBF1 WP2542 Sulindac Metabolic Pathway 0.0919938977121274 -2.38603303334898 5 2 0.00351493848857645 569 5312 253827,1545 MSRB3,CYP1B1 WP1471 Target Of Rapamycin (TOR) Signaling 0.0941577319238539 -2.36278390378991 37 7 0.0123022847100176 569 5312 5563,3422,5578,1978,3156,54541,58528 PRKAA2,IDI1,PRKCA,EIF4EBP1,HMGCR,DDIT4,RRAGD WP382 MAPK Signaling Pathway 0.0944503944119846 -2.35968050916208 170 24 0.0421792618629174 569 5312 5058,627,468,130399,3164,120892,5596,2260,9261,5579,5608,10000,5924,4609,5580,5603,140738,5602,51776,1649,5159,10125,1843,4208 PAK1,BDNF,ATF4,ACVR1C,NR4A1,LRRK2,MAPK4,FGFR1,MAPKAPK2,PRKCB,MAP2K6,AKT3,RASGRF2,MYC,PRKCD,MAPK13,TMEM37,MAPK10,MAP3K20,DDIT3,PDGFRB,RASGRP1,DUSP1,MEF2C WP2261 Signaling Pathways in Glioblastoma 0.102252883671333 -2.28030628229227 83 13 0.0228471001757469 569 5312 3480,5579,5608,10000,5580,5287,5588,4233,5578,54206,10253,2260,5159 IGF1R,PRKCB,MAP2K6,AKT3,PRKCD,PIK3C2B,PRKCQ,MET,PRKCA,ERRFI1,SPRY2,FGFR1,PDGFRB WP3527 Preimplantation Embryo 0.102908371233815 -2.27391628635282 60 10 0.0175746924428823 569 5312 83439,10265,2624,2625,1746,4306,678,1649,55509,7080 TCF7L1,IRX5,GATA2,GATA3,DLX2,NR3C2,ZFP36L2,DDIT3,BATF3,NKX2-1 WP1403 AMP-activated Protein Kinase (AMPK) Signaling 0.106108504485865 -2.24329308119403 68 11 0.0193321616871705 569 5312 5563,1938,1978,8900,2194,6720,55437,23236,3953,5567,3156 PRKAA2,EEF2,EIF4EBP1,CCNA1,FASN,SREBF1,STRADB,PLCB1,LEPR,PRKACB,HMGCR WP366 TGF-beta Signaling Pathway 0.11593696476749 -2.15470864275177 133 19 0.0333919156414763 569 5312 860,5163,2335,10413,467,5596,9372,6497,4088,7049,7015,5608,4609,3690,3673,64219,4233,8945,4208 RUNX2,PDK1,FN1,YAP1,ATF3,MAPK4,ZFYVE9,SKI,SMAD3,TGFBR3,TERT,MAP2K6,MYC,ITGB3,ITGA2,PJA1,MET,BTRC,MEF2C WP2355 Corticotropin-releasing hormone signaling pathway 0.118247780091676 -2.1349730247954 93 14 0.0246045694200351 569 5312 5563,5579,3164,2775,5580,2081,7020,5588,2870,5578,7099,157,4846,2770 PRKAA2,PRKCB,NR4A1,GNAO1,PRKCD,ERN1,TFAP2A,PRKCQ,GRK6,PRKCA,TLR4,GRK3,NOS3,GNAI1 WP3893 Development and heterogeneity of the ILC family 0.120611551234046 -2.11518021789896 32 6 0.0105448154657293 569 5312 64919,2625,9760,8320,3600,2672 BCL11B,GATA3,TOX,EOMES,IL15,GFI1 WP395 IL-4 Signaling Pathway 0.128480885168976 -2.0519751392606 55 9 0.015817223198594 569 5312 1051,8660,5777,2625,6777,1050,1147,2242,9846 CEBPB,IRS2,PTPN6,GATA3,STAT5B,CEBPA,CHUK,FES,GAB2 WP585 Interferon type I signaling pathways 0.128480885168976 -2.0519751392606 55 9 0.015817223198594 569 5312 5788,8660,5608,5966,1978,5777,6775,10399,9846 PTPRC,IRS2,MAP2K6,REL,EIF4EBP1,PTPN6,STAT4,RACK1,GAB2 WP2007 Iron metabolism in placenta 0.129483608848972 -2.04420097844834 12 3 0.00527240773286467 569 5312 55240,30061,48 STEAP3,SLC40A1,ACO1 WP3301 MFAP5-mediated ovarian cancer cell motility and invasiveness 0.129483608848972 -2.04420097844834 12 3 0.00527240773286467 569 5312 5588,9586,3690 PRKCQ,CREB5,ITGB3 WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 0.133961372098871 -2.01020378850729 144 20 0.0351493848857645 569 5312 5563,10451,627,4916,6777,1147,10399,1795,55816,8660,3781,1938,1978,5580,23426,4082,4684,1000,5602,4208 PRKAA2,VAV3,BDNF,NTRK3,STAT5B,CHUK,RACK1,DOCK3,DOK5,IRS2,KCNN2,EEF2,EIF4EBP1,PRKCD,GRIP1,MARCKS,NCAM1,CDH2,MAPK10,MEF2C WP2197 Endothelin Pathways 0.134873215155337 -2.00342008881605 33 6 0.0105448154657293 569 5312 10203,5578,23236,4846,153,2770 CALCRL,PRKCA,PLCB1,NOS3,ADRB1,GNAI1 WP581 EPO Receptor Signaling 0.138426459456052 -1.9774160730305 26 5 0.00878734622144113 569 5312 5788,8660,6777,5163,10076 PTPRC,IRS2,STAT5B,PDK1,PTPRU WP26 Signal Transduction of S1P Receptor 0.138426459456052 -1.9774160730305 26 5 0.00878734622144113 569 5312 5596,5287,23236,10000,2770 MAPK4,PIK3C2B,PLCB1,AKT3,GNAI1 WP306 Focal Adhesion 0.139034177128661 -1.97303549745118 195 26 0.0456942003514939 569 5312 7424,5058,3695,10188,5829,1292,2335,57144,1793,1286,3655,10319,5596,6414,5881,2268,3480,5608,10000,7060,3673,3690,3912,3082,4233,5159 VEGFC,PAK1,ITGB7,TNK2,PXN,COL6A2,FN1,PAK5,DOCK1,COL4A4,ITGA6,LAMC3,MAPK4,SELENOP,RAC3,FGR,IGF1R,MAP2K6,AKT3,THBS4,ITGA2,ITGB3,LAMB1,HGF,MET,PDGFRB WP3892 Development of pulmonary dendritic cells and macrophage subsets 0.15560659731574 -1.86042426893525 13 3 0.00527240773286467 569 5312 860,1435,55509 RUNX2,CSF1,BATF3 WP2035 Follicle Stimulating Hormone (FSH) signaling pathway 0.155857033321578 -1.85881614499927 27 5 0.00878734622144113 569 5312 6446,627,2870,5578,1978 SGK1,BDNF,GRK6,PRKCA,EIF4EBP1 WP477 Cytoplasmic Ribosomal Proteins 0.161810989950367 -1.82132635360899 90 13 0.0228471001757469 569 5312 6224,6154,6136,6196,6158,6205,6144,6124,6206,23521,6228,6207,6164 RPS20,RPL26,RPL12,RPS6KA2,RPL28,RPS11,RPL21,RPL4,RPS12,RPL13A,RPS23,RPS13,RPL34 WP2572 Primary Focal Segmental Glomerulosclerosis FSGS 0.163644813697406 -1.81005696996759 74 11 0.0193321616871705 569 5312 1285,2195,1286,3690,4040,1287,7431,1000,7099,4311,22943 COL4A3,FAT1,COL4A4,ITGB3,LRP6,COL4A5,VIM,CDH2,TLR4,MME,DKK1 WP2324 AGE/RAGE pathway 0.163683892334825 -1.80981819691234 66 10 0.0175746924428823 569 5312 4088,5321,3958,5579,5580,4481,6777,1147,5578,4846 SMAD3,PLA2G4A,LGALS3,PRKCB,PRKCD,MSR1,STAT5B,CHUK,PRKCA,NOS3 WP244 Alpha 6 Beta 4 signaling pathway 0.165615847160883 -1.79808434619353 35 6 0.0105448154657293 569 5312 8660,5578,1978,3655,5580,3912 IRS2,PRKCA,EIF4EBP1,ITGA6,PRKCD,LAMB1 WP3924 Hfe effect on hepcidin production 0.167522777358701 -1.78663595273098 7 2 0.00351493848857645 569 5312 3397,654 ID1,BMP6 WP3303 Rac1/Pak1/p38/MMP-2 pathway 0.187149218023646 -1.67584902298055 68 10 0.0175746924428823 569 5312 5058,5829,2335,2888,1978,4609,10413,6777,5603,1147 PAK1,PXN,FN1,GRB14,EIF4EBP1,MYC,YAP1,STAT5B,MAPK13,CHUK WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway 0.187149218023646 -1.67584902298055 68 10 0.0175746924428823 569 5312 30818,3480,5608,2775,4609,5144,5337,7253,23236,2770 KCNIP3,IGF1R,MAP2K6,GNAO1,MYC,PDE4D,PLD1,TSHR,PLCB1,GNAI1 WP2643 Nanoparticle-mediated activation of receptor signaling 0.193183947699035 -1.64411244709951 29 5 0.00878734622144113 569 5312 5603,5829,2335,5602,10000 MAPK13,PXN,FN1,MAPK10,AKT3 WP3614 Photodynamic therapy-induced HIF-1 survival signaling 0.199009239308041 -1.6144040266518 37 6 0.0105448154657293 569 5312 664,3098,5366,7039,3486,665 BNIP3,HK1,PMAIP1,TGFA,IGFBP3,BNIP3L WP2431 Spinal Cord Injury 0.200976051078268 -1.60456952688619 119 16 0.0281195079086116 569 5312 1948,3627,627,3958,3164,4609,64131,10673,5362,7431,900,63827,5578,7099,57556,9353 EFNB2,CXCL10,BDNF,LGALS3,NR4A1,MYC,XYLT1,TNFSF13B,PLXNA2,VIM,CCNG1,BCAN,PRKCA,TLR4,SEMA6A,SLIT2 WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 0.205159982255296 -1.5839652029531 162 21 0.0369068541300527 569 5312 627,6331,2597,720,6262,2625,5577,6616,6507,9722,1051,2624,4133,226,4128,1746,5452,10891,5567,4208,478 BDNF,SCN5A,GAPDH,C4A,RYR2,GATA3,PRKAR2B,SNAP25,SLC1A3,NOS1AP,CEBPB,GATA2,MAP2,ALDOA,MAOA,DLX2,POU2F2,PPARGC1A,PRKACB,MEF2C,ATP1A3 WP3 Transcriptional activation by NRF2 0.211915607953288 -1.55156715925533 15 3 0.00527240773286467 569 5312 1051,23657,5578 CEBPB,SLC7A11,PRKCA WP2870 Extracellular vesicle-mediated signaling in recipient cells 0.212921348384066 -1.54683243787748 30 5 0.00878734622144113 569 5312 4088,3082,7049,4233,7039 SMAD3,HGF,TGFBR3,MET,TGFA WP673 ErbB Signaling Pathway 0.216480954862726 -1.53025270371053 54 8 0.0140597539543058 569 5312 685,10718,5163,10000,1978,4609,7039,5578 BTC,NRG3,PDK1,AKT3,EIF4EBP1,MYC,TGFA,PRKCA WP465 Tryptophan metabolism 0.217358199670655 -1.52620859660604 46 7 0.0123022847100176 569 5312 217,51166,6999,1573,1718,7453,1545 ALDH2,AADAT,TDO2,CYP2J2,DHCR24,WARS,CYP1B1 WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 0.23370010015473 -1.45371660887631 47 7 0.0123022847100176 569 5312 6777,7292,1978,6775,4609,2242,9846 STAT5B,TNFSF4,EIF4EBP1,STAT4,MYC,FES,GAB2 WP710 DNA Damage Response (only ATM dependent) 0.235614037748786 -1.44556024600523 114 15 0.0263620386643234 569 5312 4088,83439,5163,5366,10000,4609,638,3949,604,27113,5287,7481,5106,5602,5881 SMAD3,TCF7L1,PDK1,PMAIP1,AKT3,MYC,BIK,LDLR,BCL6,BBC3,PIK3C2B,WNT11,PCK2,MAPK10,RAC3 WP2291 Deregulation of Rab and Rab Effector Genes in Bladder Cancer 0.24152752773849 -1.42077182589069 16 3 0.00527240773286467 569 5312 23086,5874,25924 EXPH5,RAB27B,MYRIP WP53 ID signaling pathway 0.24152752773849 -1.42077182589069 16 3 0.00527240773286467 569 5312 3399,3397,6720 ID3,ID1,SREBF1 WP3593 miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma 0.249790180508326 -1.38713399147752 9 2 0.00351493848857645 569 5312 7424,23462 VEGFC,HEY1 WP288 NLR Proteins 0.249790180508326 -1.38713399147752 9 2 0.00351493848857645 569 5312 1147,958 CHUK,CD40 WP3674 Tgif disruption of Shh signaling 0.249790180508326 -1.38713399147752 9 2 0.00351493848857645 569 5312 2290,7080 FOXG1,NKX2-1 WP3858 Toll-like Receptor Signaling 0.254125000706694 -1.36992900425273 32 5 0.00878734622144113 569 5312 1147,7098,10333,7099,5966 CHUK,TLR3,TLR6,TLR4,REL WP534 Glycolysis and Gluconeogenesis 0.267516362718929 -1.3185745454741 49 7 0.0123022847100176 569 5312 3098,2597,2026,2023,230,226,3099 HK1,GAPDH,ENO2,ENO1,ALDOC,ALDOA,HK2 WP3676 BDNF-TrkB Signaling 0.275419962410283 -1.2894582101646 33 5 0.00878734622144113 569 5312 627,7222,1978,107,9846 BDNF,TRPC3,EIF4EBP1,ADCY1,GAB2 WP3668 Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 0.276413954067115 -1.2858557033155 25 4 0.0070298769771529 569 5312 4088,860,7049,2200 SMAD3,RUNX2,TGFBR3,FBN1 WP560 TGF-beta Receptor Signaling 0.27838087910324 -1.27876503426259 58 8 0.0140597539543058 569 5312 4088,860,7049,4093,652,4091,9372,6497 SMAD3,RUNX2,TGFBR3,SMAD9,BMP4,SMAD6,ZFYVE9,SKI WP3408 Evolocumab Mechanism 0.288203676083249 -1.24408784017798 3 1 0.00175746924428822 569 5312 3949 LDLR WP2846 Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation 0.288203676083249 -1.24408784017798 3 1 0.00175746924428822 569 5312 3949 LDLR WP2333 Trans-sulfuration pathway 0.291540858644012 -1.23257511613922 10 2 0.00351493848857645 569 5312 875,1491 CBS,CTH WP2037 Prolactin Signaling Pathway 0.293616690657865 -1.22548013556785 76 10 0.0175746924428823 569 5312 5058,8660,6196,5829,1978,5777,4609,116986,6777,9846 PAK1,IRS2,RPS6KA2,PXN,EIF4EBP1,PTPN6,MYC,AGAP2,STAT5B,GAB2 WP2064 Neural Crest Differentiation 0.294989093480077 -1.22081689457975 102 13 0.0228471001757469 569 5312 83439,4487,3397,4609,85416,7020,1488,652,1000,3198,6591,2260,7545 TCF7L1,MSX1,ID1,MYC,ZIC5,TFAP2A,CTBP2,BMP4,CDH2,HOXA1,SNAI2,FGFR1,ZIC1 WP400 p38 MAPK Signaling Pathway 0.297063230576487 -1.21381026527498 34 5 0.00878734622144113 569 5312 9261,5321,5608,4609,1649 MAPKAPK2,PLA2G4A,MAP2K6,MYC,DDIT3 WP313 Signaling of Hepatocyte Growth Factor Receptor 0.297063230576487 -1.21381026527498 34 5 0.00878734622144113 569 5312 5058,3082,5829,4233,1793 PAK1,HGF,PXN,MET,DOCK1 WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways 0.302063183799884 -1.19711906560987 68 9 0.015817223198594 569 5312 5058,2335,8322,8325,4609,7039,7481,5217,8321 PAK1,FN1,FZD4,FZD8,MYC,TGFA,WNT11,PFN2,FZD1 WP1455 Serotonin Transporter Activity 0.332969556616791 -1.0997042147521 11 2 0.00351493848857645 569 5312 4128,3690 MAOA,ITGB3 WP2513 Nanoparticle triggered regulated necrosis 0.332969556616791 -1.0997042147521 11 2 0.00351493848857645 569 5312 5321,7132 PLA2G4A,TNFRSF1A WP3877 Simplified Depiction of MYD88 Distinct Input-Output Pathway 0.333084871207254 -1.0993579529849 19 3 0.00527240773286467 569 5312 92610,10333,7099 TIFA,TLR6,TLR4 WP2406 Cardiac Progenitor Differentiation 0.338453899758157 -1.08336738568836 53 7 0.0123022847100176 569 5312 6331,652,91807,4684,22943,4208,649 SCN5A,BMP4,MYLK3,NCAM1,DKK1,MEF2C,BMP1 WP3298 Melatonin metabolism and effects 0.341062230335387 -1.0756903246964 36 5 0.00878734622144113 569 5312 4128,5578,4133,1545,153 MAOA,PRKCA,MAP2,CYP1B1,ADRB1 WP516 Hypertrophy Model 0.363765702926749 -1.01124529187014 20 3 0.00527240773286467 569 5312 467,2660,1978 ATF3,MSTN,EIF4EBP1 WP1742 TP53 Network 0.363765702926749 -1.01124529187014 20 3 0.00527240773286467 569 5312 27113,5366,4609 BBC3,PMAIP1,MYC WP1422 Sphingolipid Metabolism 0.363765702926749 -1.01124529187014 20 3 0.00527240773286467 569 5312 8611,79603,9331 PLPP1,CERS4,B4GALT6 WP497 Urea cycle and metabolism of amino groups 0.363765702926749 -1.01124529187014 20 3 0.00527240773286467 569 5312 445,2628,5831 ASS1,GATM,PYCR1 WP2889 Oxytocin signaling 0.364491509631926 -1.00925202099559 4 1 0.00175746924428822 569 5312 5021 OXTR WP897 Androgen receptor signaling pathway 0.364491509631926 -1.00925202099559 4 1 0.00175746924428822 569 5312 8611 PLPP1 WP1133 Androgen receptor signaling pathway 0.364491509631926 -1.00925202099559 4 1 0.00175746924428822 569 5312 8611 PLPP1 WP1591 Heart Development 0.370211570800002 -0.993680623793631 46 6 0.0105448154657293 569 5312 7424,652,657,659,23462,4208 VEGFC,BMP4,BMPR1A,BMPR2,HEY1,MEF2C WP3849 MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ 0.373666746174136 -0.984390931801654 12 2 0.00351493848857645 569 5312 1147,5608 CHUK,MAP2K6 WP106 Alanine and aspartate metabolism 0.373666746174136 -0.984390931801654 12 2 0.00351493848857645 569 5312 445,18 ASS1,ABAT WP2290 RalA downstream regulated genes 0.373666746174136 -0.984390931801654 12 2 0.00351493848857645 569 5312 8531,5881 YBX3,RAC3 WP2583 T-Cell Receptor and Co-stimulatory Signaling 0.377737377451662 -0.97355609347253 29 4 0.0070298769771529 569 5312 5163,5578,5777,10125 PDK1,PRKCA,PTPN6,RASGRP1 WP422 MAPK Cascade 0.377737377451662 -0.97355609347253 29 4 0.0070298769771529 569 5312 22821,5602,4133,5608 RASA3,MAPK10,MAP2,MAP2K6 WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 0.383024928402731 -0.959655204706175 91 11 0.0193321616871705 569 5312 5058,10451,5966,5580,2625,1147,7431,5588,3937,8631,9846 PAK1,VAV3,REL,PRKCD,GATA3,CHUK,VIM,PRKCQ,LCP2,SKAP1,GAB2 WP3925 Amino Acid metabolism 0.383024928402731 -0.959655204706175 91 11 0.0193321616871705 569 5312 84706,440,1962,6999,8974,4128,875,445,7453,1491,5831 GPT2,ASNS,EHHADH,TDO2,P4HA2,MAOA,CBS,ASS1,WARS,CTH,PYCR1 WP1602 Nicotine Activity on Dopaminergic Neurons 0.394209477746017 -0.930872841564171 21 3 0.00527240773286467 569 5312 8973,1138,2770 CHRNA6,CHRNA5,GNAI1 WP3670 Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 0.394209477746017 -0.930872841564171 21 3 0.00527240773286467 569 5312 84171,2335,780 LOXL4,FN1,DDR1 WP2855 Dopaminergic Neurogenesis 0.403093689617135 -0.908586263615304 30 4 0.0070298769771529 569 5312 4825,4487,63973,2735 NKX6-1,MSX1,NEUROG2,GLI1 WP3844 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 0.403093689617135 -0.908586263615304 30 4 0.0070298769771529 569 5312 2887,5163,1978,4846 GRB10,PDK1,EIF4EBP1,NOS3 WP3651 Pathways Affected in Adenoid Cystic Carcinoma 0.412071834483914 -0.886557589287292 66 8 0.0140597539543058 569 5312 93986,2264,54756,64324,4609,84159,1050,9863 FOXP2,FGFR4,IL17RD,NSD1,MYC,ARID5B,CEBPA,MAGI2 WP2374 Oncostatin M Signaling Pathway 0.412071834483914 -0.886557589287292 66 8 0.0140597539543058 569 5312 1051,5829,5579,5580,3949,6777,5578,3977 CEBPB,PXN,PRKCB,PRKCD,LDLR,STAT5B,PRKCA,LIFR WP3871 Valproic acid pathway 0.413314045972783 -0.883547573108988 13 2 0.00351493848857645 569 5312 18,1962 ABAT,EHHADH WP1991 SRF and miRs in Smooth Muscle Differentiation and Proliferation 0.413314045972783 -0.883547573108988 13 2 0.00351493848857645 569 5312 100271849,4208 MEF2B,MEF2C WP3876 BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation 0.413314045972783 -0.883547573108988 13 2 0.00351493848857645 569 5312 4093,22943 SMAD9,DKK1 WP1434 Osteopontin Signaling 0.413314045972783 -0.883547573108988 13 2 0.00351493848857645 569 5312 1147,3690 CHUK,ITGB3 WP1423 Ganglio Sphingolipid Metabolism 0.413314045972783 -0.883547573108988 13 2 0.00351493848857645 569 5312 8708,6489 B3GALT1,ST8SIA1 WP545 Complement Activation 0.424258354754578 -0.857412682063289 22 3 0.00527240773286467 569 5312 715,1604,720 C1R,CD55,C4A WP357 Fatty Acid Biosynthesis 0.424258354754578 -0.857412682063289 22 3 0.00527240773286467 569 5312 6319,2180,2194 SCD,ACSL1,FASN WP2112 IL17 signaling pathway 0.428253714121915 -0.848039469026456 31 4 0.0070298769771529 569 5312 1051,53342,54756,1052 CEBPB,IL17D,IL17RD,CEBPD WP524 G13 Signaling Pathway 0.429742141599273 -0.844569920868281 40 5 0.00878734622144113 569 5312 85415,10188,5585,5602,57630 RHPN2,TNK2,PKN1,MAPK10,SH3RF1 WP410 Diurnally Regulated Genes with Circadian Orthologs 0.430056767835219 -0.843838060786729 49 6 0.0105448154657293 569 5312 1051,2947,687,3422,2674,9709 CEBPB,GSTM3,KLF9,IDI1,GFRA1,HERPUD1 WP3596 miR-517 relationship with ARCN1 and USP1 0.432615912608323 -0.837904982486599 5 1 0.00175746924428822 569 5312 3397 ID1 WP688 Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) 0.432615912608323 -0.837904982486599 5 1 0.00175746924428822 569 5312 2329 FMO4 WP2637 Structural Pathway of Interleukin 1 (IL-1) 0.449850350065485 -0.798840306936618 50 6 0.0105448154657293 569 5312 9261,1147,5602,5608,3556,4609 MAPKAPK2,CHUK,MAPK10,MAP2K6,IL1RAP,MYC WP322 Osteoblast Signaling 0.451669447837635 -0.794804676781303 14 2 0.00351493848857645 569 5312 5159,3690 PDGFRB,ITGB3 WP229 Irinotecan Pathway 0.451669447837635 -0.794804676781303 14 2 0.00351493848857645 569 5312 1244,590 ABCC2,BCHE WP2436 Dopamine metabolism 0.451669447837635 -0.794804676781303 14 2 0.00351493848857645 569 5312 4128,5567 MAOA,PRKACB WP727 Monoamine Transport 0.453129244606771 -0.791577886009025 32 4 0.0070298769771529 569 5312 114907,10497,6999,3690 FBXO32,UNC13B,TDO2,ITGB3 WP2525 Trans-sulfuration and one carbon metabolism 0.453129244606771 -0.791577886009025 32 4 0.0070298769771529 569 5312 875,26227,5723,1491 CBS,PHGDH,PSPH,CTH WP3612 Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling 0.45377555409223 -0.790152577430216 23 3 0.00527240773286467 569 5312 5603,1244,10257 MAPK13,ABCC2,ABCC4 WP558 Complement and Coagulation Cascades 0.466023372302556 -0.763519490958519 60 7 0.0123022847100176 569 5312 1380,715,5627,2161,1604,3075,2152 CR2,C1R,PROS1,F12,CD55,CFH,F3 WP304 Kit receptor signaling pathway 0.466023372302556 -0.763519490958519 60 7 0.0123022847100176 569 5312 2887,6777,5578,5579,5777,6591,9846 GRB10,STAT5B,PRKCA,PRKCB,PTPN6,SNAI2,GAB2 WP2636 Common Pathways Underlying Drug Addiction 0.473320711559057 -0.74798208313078 42 5 0.00878734622144113 569 5312 5578,5579,5567,107,2770 PRKCA,PRKCB,PRKACB,ADCY1,GNAI1 WP453 Inflammatory Response Pathway 0.47764086973782 -0.738896147412028 33 4 0.0070298769771529 569 5312 958,2335,3912,7132 CD40,FN1,LAMB1,TNFRSF1A WP430 Statin Pathway 0.47764086973782 -0.738896147412028 33 4 0.0070298769771529 569 5312 6713,5360,3949,3156 SQLE,PLTP,LDLR,HMGCR WP334 GPCRs, Class B Secretin-like 0.482644309967858 -0.728475314904715 24 3 0.00527240773286467 569 5312 10203,23266,22859 CALCRL,ADGRL2,ADGRL1 WP3658 Wnt/beta-catenin Signaling Pathway in Leukemia 0.482644309967858 -0.728475314904715 24 3 0.00527240773286467 569 5312 4040,26108,22943 LRP6,PYGO1,DKK1 WP3865 RIG-I-like Receptor Signaling 0.483971063531611 -0.725730160144477 61 7 0.0123022847100176 569 5312 54941,3627,1147,9755,5603,9474,5602 RNF125,CXCL10,CHUK,TBKBP1,MAPK13,ATG5,MAPK10 WP1449 Regulation of toll-like receptor signaling pathway 0.489889138022232 -0.713576162409836 145 16 0.0281195079086116 569 5312 5777,1147,79004,958,10333,3627,7098,92610,57161,10000,5608,5603,4091,5602,7099,6850 PTPN6,CHUK,CUEDC2,CD40,TLR6,CXCL10,TLR3,TIFA,PELI2,AKT3,MAP2K6,MAPK13,SMAD6,MAPK10,TLR4,SYK WP1981 Thyroxine (Thyroid Hormone) Production 0.493449066128955 -0.7063356349002 6 1 0.00175746924428822 569 5312 7253 TSHR WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 0.501746241154112 -0.689660782805377 62 7 0.0123022847100176 569 5312 5058,5788,5588,1147,5163,3937,5777 PAK1,PTPRC,PRKCQ,CHUK,PDK1,LCP2,PTPN6 WP3624 Lung fibrosis 0.519319241249027 -0.655236476538239 63 7 0.0123022847100176 569 5312 1051,3082,23250,10144,7015,1832,7039 CEBPB,HGF,ATP11A,FAM13A,TERT,DSP,TGFA WP43 Oxidation by Cytochrome P450 0.519319241249027 -0.655236476538239 63 7 0.0123022847100176 569 5312 1595,113612,51700,1573,1592,285440,1545 CYP51A1,CYP2U1,CYB5R2,CYP2J2,CYP26A1,CYP4V2,CYP1B1 WP12 Osteoclast Signaling 0.523844243436686 -0.646560884197086 16 2 0.00351493848857645 569 5312 8792,3690 TNFRSF11A,ITGB3 WP1946 Cori Cycle 0.523844243436686 -0.646560884197086 16 2 0.00351493848857645 569 5312 3098,2597 HK1,GAPDH WP47 Hedgehog Signaling Pathway 0.523844243436686 -0.646560884197086 16 2 0.00351493848857645 569 5312 8643,2735 PTCH2,GLI1 WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer 0.527085351735932 -0.640392785801324 54 6 0.0105448154657293 569 5312 7431,10451,8531,5585,27018,2081 VIM,VAV3,YBX3,PKN1,BEX3,ERN1 WP325 Triacylglyceride Synthesis 0.538061941022495 -0.619781593435462 26 3 0.00527240773286467 569 5312 8611,56895,8612 PLPP1,AGPAT4,PLPP2 WP2878 PPAR Alpha Pathway 0.538061941022495 -0.619781593435462 26 3 0.00527240773286467 569 5312 1962,5360,4609 EHHADH,PLTP,MYC WP2272 Pathogenic Escherichia coli infection 0.545723642927375 -0.605642579858277 55 6 0.0105448154657293 569 5312 10382,2017,7846,5578,7099,100506658 TUBB4A,CTTN,TUBA1A,PRKCA,TLR4,OCLN WP2018 RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway 0.545723642927375 -0.605642579858277 55 6 0.0105448154657293 569 5312 1147,5608,6850,8792,9846,2274 CHUK,MAP2K6,SYK,TNFRSF11A,GAB2,FHL2 WP1310 Selenium Micronutrient Network 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 114112 TXNRD3 WP1272 Selenium Micronutrient Network 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 114112 TXNRD3 WP528 Acetylcholine Synthesis 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 10400 PEMT WP3595 mir-124 predicted interactions with cell cycle and differentiation 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 55437 STRADB WP678 Arachidonate Epoxygenase / Epoxide Hydrolase 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 1573 CYP2J2 WP1995 Effects of Nitric Oxide 0.547770114255595 -0.601899579582252 7 1 0.00175746924428822 569 5312 4846 NOS3 WP2289 Drug Induction of Bile Acid Pathway 0.557456422405134 -0.584370944792437 17 2 0.00351493848857645 569 5312 1244,10257 ABCC2,ABCC4 WP554 ACE Inhibitor Pathway 0.557456422405134 -0.584370944792437 17 2 0.00351493848857645 569 5312 4306,4846 NR3C2,NOS3 WP368 Mitochondrial LC-Fatty Acid Beta-Oxidation 0.557456422405134 -0.584370944792437 17 2 0.00351493848857645 569 5312 2180,1962 ACSL1,EHHADH WP3845 Canonical and Non-canonical Notch signaling 0.564465652231967 -0.571875743599761 27 3 0.00527240773286467 569 5312 1147,92737,23462 CHUK,DNER,HEY1 WP195 IL-1 signaling pathway 0.581978118590781 -0.541322428880538 57 6 0.0105448154657293 569 5312 9261,1147,5608,5966,3556,57161 MAPKAPK2,CHUK,MAP2K6,REL,IL1RAP,PELI2 WP254 Apoptosis 0.582053307942082 -0.541193241043007 86 9 0.015817223198594 569 5312 3480,5366,4609,7132,665,27113,8739,1147,5602 IGF1R,PMAIP1,MYC,TNFRSF1A,BNIP3L,BBC3,HRK,CHUK,MAPK10 WP3664 Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds 0.589345144037917 -0.528743283865151 18 2 0.00351493848857645 569 5312 8325,8321 FZD8,FZD1 WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 0.589345144037917 -0.528743283865151 18 2 0.00351493848857645 569 5312 5608,1978 MAP2K6,EIF4EBP1 WP2526 PDGF Pathway 0.592557561964533 -0.523307259696711 38 4 0.0070298769771529 569 5312 5058,5321,1147,5159 PAK1,PLA2G4A,CHUK,PDGFRB WP383 Striated Muscle Contraction 0.592557561964533 -0.523307259696711 38 4 0.0070298769771529 569 5312 59,7431,7168,4703 ACTA2,VIM,TPM1,NEB WP2873 Aryl Hydrocarbon Receptor Pathway 0.595914324076404 -0.517658373799689 48 5 0.00878734622144113 569 5312 57491,10486,8140,23491,1545 AHRR,CAP2,SLC7A5,CES3,CYP1B1 WP2849 Hematopoietic Stem Cell Differentiation 0.595914324076404 -0.517658373799689 48 5 0.00878734622144113 569 5312 4601,2624,3071,1435,3690 MXI1,GATA2,NCKAP1L,CSF1,ITGB3 WP2586 Aryl Hydrocarbon Receptor 0.595914324076404 -0.517658373799689 48 5 0.00878734622144113 569 5312 57491,5325,4609,135112,1545 AHRR,PLAGL1,MYC,NCOA7,CYP1B1 WP3635 Insulin signalling in human adipocytes (diabetic condition) 0.596275072792221 -0.517053186859132 8 1 0.00175746924428822 569 5312 9882 TBC1D4 WP136 Phase I biotransformations, non P450 0.596275072792221 -0.517053186859132 8 1 0.00175746924428822 569 5312 2098 ESD WP3634 Insulin signalling in human adipocytes (normal condition) 0.596275072792221 -0.517053186859132 8 1 0.00175746924428822 569 5312 9882 TBC1D4 WP1604 Codeine and Morphine Metabolism 0.596275072792221 -0.517053186859132 8 1 0.00175746924428822 569 5312 1244 ABCC2 WP3655 Hypothetical Craniofacial Development Pathway 0.596275072792221 -0.517053186859132 8 1 0.00175746924428822 569 5312 7020 TFAP2A WP22 IL-9 Signaling Pathway 0.61949341142598 -0.478853213278648 19 2 0.00351493848857645 569 5312 6777,3581 STAT5B,IL9R WP3287 Overview of nanoparticle effects 0.61949341142598 -0.478853213278648 19 2 0.00351493848857645 569 5312 2335,10000 FN1,AKT3 WP2879 Farnesoid X Receptor Pathway 0.61949341142598 -0.478853213278648 19 2 0.00351493848857645 569 5312 8660,10891 IRS2,PPARGC1A WP734 Serotonin Receptor 4/6/7 and NR3C Signaling 0.61949341142598 -0.478853213278648 19 2 0.00351493848857645 569 5312 3363,9261 HTR7,MAPKAPK2 WP384 Apoptosis Modulation by HSP70 0.61949341142598 -0.478853213278648 19 2 0.00351493848857645 569 5312 5602,7132 MAPK10,TNFRSF1A WP2359 Parkin-Ubiquitin Proteasomal System pathway 0.634616314212141 -0.454734692296889 70 7 0.0123022847100176 569 5312 2861,10382,5071,5413,7846,3306,6622 GPR37,TUBB4A,PRKN,SEPT5,TUBA1A,HSPA2,SNCA WP561 Heme Biosynthesis 0.639585684329127 -0.446934680497453 9 1 0.00175746924428822 569 5312 7390 UROS WP3297 EV release from cardiac cells and their functional effects 0.639585684329127 -0.446934680497453 9 1 0.00175746924428822 569 5312 6004 RGS16 WP696 Benzo(a)pyrene metabolism 0.639585684329127 -0.446934680497453 9 1 0.00175746924428822 569 5312 1545 CYP1B1 WP3594 Circadian rythm related genes 0.640352316494204 -0.44573675957275 207 21 0.0369068541300527 569 5312 5563,9099,468,55366,50865,107,4916,114781,3363,3399,23596,6720,5593,148523,687,1628,10891,5602,8792,8945,7080 PRKAA2,USP2,ATF4,LGR4,HEBP1,ADCY1,NTRK3,BTBD9,HTR7,ID3,OPN3,SREBF1,PRKG2,CIART,KLF9,DBP,PPARGC1A,MAPK10,TNFRSF11A,BTRC,NKX2-1 WP732 Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 0.647907601257043 -0.434007183449588 20 2 0.00351493848857645 569 5312 9261,10125 MAPKAPK2,RASGRP1 WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway 0.65385392351024 -0.424871311020207 41 4 0.0070298769771529 569 5312 10910,84674,1147,639 SUGT1,CARD6,CHUK,PRDM1 WP2267 Synaptic Vesicle Pathway 0.668094246332253 -0.40332602807364 52 5 0.00878734622144113 569 5312 26052,6616,6507,10497,6812 DNM3,SNAP25,SLC1A3,UNC13B,STXBP1 WP3915 Angiopoietin Like Protein 8 Regulatory Pathway 0.669507365621375 -0.401213112236483 132 13 0.0228471001757469 569 5312 5563,8660,23433,6196,5608,1978,6567,2194,6720,6319,5603,5596,5602 PRKAA2,IRS2,RHOQ,RPS6KA2,MAP2K6,EIF4EBP1,SLC16A2,FASN,SREBF1,SCD,MAPK13,MAPK4,MAPK10 WP49 IL-2 Signaling Pathway 0.672857419505107 -0.396221829872985 42 4 0.0070298769771529 569 5312 6777,6850,4609,9846 STAT5B,SYK,MYC,GAB2 WP75 Toll-like Receptor Signaling Pathway 0.677711925476596 -0.3890329700101 103 10 0.0175746924428823 569 5312 3627,7098,5608,10000,5603,1147,958,7099,5602,10333 CXCL10,TLR3,MAP2K6,AKT3,MAPK13,CHUK,CD40,TLR4,MAPK10,TLR6 WP3601 Composition of Lipid Particles 0.678257331615071 -0.388228517895811 10 1 0.00175746924428822 569 5312 3949 LDLR WP3656 Interleukin-1 Induced Activation of NF-kappa-B 0.678257331615071 -0.388228517895811 10 1 0.00175746924428822 569 5312 92610 TIFA WP1531 Vitamin D Metabolism 0.678257331615071 -0.388228517895811 10 1 0.00175746924428822 569 5312 1717 DHCR7 WP2875 Constitutive Androstane Receptor Pathway 0.681788927803155 -0.383035159065296 32 3 0.00527240773286467 569 5312 1244,10891,1962 ABCC2,PPARGC1A,EHHADH WP363 Wnt Signaling Pathway Netpath 0.684755650509234 -0.378693218942754 53 5 0.00878734622144113 569 5312 4040,4919,5578,5579,4609 LRP6,ROR1,PRKCA,PRKCB,MYC WP1772 Apoptosis Modulation and Signaling 0.690022520393467 -0.371031043672046 94 9 0.015817223198594 569 5312 27113,664,8739,9531,8794,5366,5783,638,7132 BBC3,BNIP3,HRK,BAG3,TNFRSF10C,PMAIP1,PTPN13,BIK,TNFRSF1A WP3872 Regulation of Apoptosis by Parathyroid Hormone-related Protein 0.699648098101668 -0.357177787340906 22 2 0.00351493848857645 569 5312 4609,3655 MYC,ITGA6 WP167 Eicosanoid Synthesis 0.699648098101668 -0.357177787340906 22 2 0.00351493848857645 569 5312 241,9536 ALOX5AP,PTGES WP100 Glutathione metabolism 0.699648098101668 -0.357177787340906 22 2 0.00351493848857645 569 5312 26873,2946 OPLAH,GSTM2 WP3645 NAD+ biosynthetic pathways 0.699648098101668 -0.357177787340906 22 2 0.00351493848857645 569 5312 6999,23475 TDO2,QPRT WP3286 Copper homeostasis 0.700844456499149 -0.355469304586667 54 5 0.00878734622144113 569 5312 55240,26872,23621,540,475 STEAP3,STEAP1,BACE1,ATP7B,ATOX1 WP58 Monoamine GPCRs 0.702203733609263 -0.353531698245047 33 3 0.00527240773286467 569 5312 3363,1131,153 HTR7,CHRM3,ADRB1 WP2332 Interleukin-11 Signaling Pathway 0.708663988602781 -0.344373787773207 44 4 0.0070298769771529 569 5312 1147,860,3673,2242 CHUK,RUNX2,ITGA2,FES WP80 Nucleotide GPCRs 0.712786109119553 -0.338573890782607 11 1 0.00175746924428822 569 5312 5028 P2RY1 WP2034 Leptin signaling pathway 0.719646379328394 -0.328995327442378 76 7 0.0123022847100176 569 5312 5563,1147,6777,3953,5966,1978,4846 PRKAA2,CHUK,STAT5B,LEPR,REL,EIF4EBP1,NOS3 WP702 Metapathway biotransformation 0.72188208822351 -0.325893466136104 177 17 0.0298769771528998 569 5312 2946,2948,4259,1573,285440,9446,1592,9486,1595,7881,119391,2329,2947,113612,9953,266722,1545 GSTM2,GSTM4,MGST3,CYP2J2,CYP4V2,GSTO1,CYP26A1,CHST10,CYP51A1,KCNAB1,GSTO2,FMO4,GSTM3,CYP2U1,HS3ST3B1,HS6ST3,CYP1B1 WP15 Selenium Micronutrient Network 0.728505098237218 -0.316760655104766 87 8 0.0140597539543058 569 5312 241,8564,3949,140606,875,6414,114112,1491 ALOX5AP,KMO,LDLR,SELENOM,CBS,SELENOP,TXNRD3,CTH WP3617 Photodynamic therapy-induced NF-kB survival signaling 0.740009415313174 -0.301092369468682 35 3 0.00527240773286467 569 5312 1147,5966,7132 CHUK,REL,TNFRSF1A WP299 Nuclear Receptors in Lipid Metabolism and Toxicity 0.740009415313174 -0.301092369468682 35 3 0.00527240773286467 569 5312 1244,1592,9619 ABCC2,CYP26A1,ABCG1 WP28 Selenium Metabolism and Selenoproteins 0.741533365227839 -0.299035121480758 46 4 0.0070298769771529 569 5312 140606,6414,1491,114112 SELENOM,SELENOP,CTH,TXNRD3 WP3672 LncRNA-mediated mechanisms of therapeutic resistance 0.743615142123671 -0.296231660077423 12 1 0.00175746924428822 569 5312 401491 VLDLR-AS1 WP262 EBV LMP1 signaling 0.744920914586451 -0.294477221154926 24 2 0.00351493848857645 569 5312 9260,1147 PDLIM7,CHUK WP2795 Cardiac Hypertrophic Response 0.745647464214801 -0.293502358550534 57 5 0.00878734622144113 569 5312 1147,5578,5608,7132,5592 CHUK,PRKCA,MAP2K6,TNFRSF1A,PRKG1 WP500 Glycogen Metabolism 0.757435034788046 -0.277817507932485 36 3 0.00527240773286467 569 5312 5521,178,5523 PPP2R2B,AGL,PPP2R3A WP1528 Physiological and Pathological Hypertrophy of the Heart 0.765282156618863 -0.267510680975949 25 2 0.00351493848857645 569 5312 5579,3977 PRKCB,LIFR WP205 IL-7 Signaling Pathway 0.765282156618863 -0.267510680975949 25 2 0.00351493848857645 569 5312 6777,4609 STAT5B,MYC WP2881 Estrogen Receptor Pathway 0.771140233477329 -0.25988503677331 13 1 0.00175746924428822 569 5312 1545 CYP1B1 WP2848 Differentiation Pathway 0.771512509122706 -0.259402393282233 48 4 0.0070298769771529 569 5312 3082,652,1435,22943 HGF,BMP4,CSF1,DKK1 WP3529 Zinc homeostasis 0.773906336788602 -0.256304424615972 37 3 0.00527240773286467 569 5312 23516,7782,64116 SLC39A14,SLC30A4,SLC39A8 WP619 Type II interferon signaling (IFNG) 0.773906336788602 -0.256304424615972 37 3 0.00527240773286467 569 5312 3627,2633,5580 CXCL10,GBP1,PRKCD WP1544 MicroRNAs in cardiomyocyte hypertrophy 0.778891781868148 -0.249883162057912 102 9 0.015817223198594 569 5312 4040,1147,5596,91807,3480,5579,5608,8321,5592 LRP6,CHUK,MAPK4,MYLK3,IGF1R,PRKCB,MAP2K6,FZD1,PRKG1 WP698 Glucuronidation 0.784217174581704 -0.24306928859644 26 2 0.00351493848857645 569 5312 3098,7358 HK1,UGDH WP530 Cytokines and Inflammatory Response 0.784217174581704 -0.24306928859644 26 2 0.00351493848857645 569 5312 3600,1435 IL15,CSF1 WP286 IL-3 Signaling Pathway 0.785445907829322 -0.241503687019431 49 4 0.0070298769771529 569 5312 6777,6850,5777,9846 STAT5B,SYK,PTPN6,GAB2 WP3853 ERK Pathway in Huntington's Disease 0.795714909286994 -0.228514311452343 14 1 0.00175746924428822 569 5312 627 BDNF WP615 Senescence and Autophagy in Cancer 0.81577216807097 -0.203620168798605 106 9 0.015817223198594 569 5312 1051,4088,2934,3480,2335,9966,9474,3486,23710 CEBPB,SMAD3,GSN,IGF1R,FN1,TNFSF15,ATG5,IGFBP3,GABARAPL1 WP206 Fatty Acid Omega Oxidation 0.817654927518836 -0.201314880381688 15 1 0.00175746924428822 569 5312 217 ALDH2 WP127 IL-5 Signaling Pathway 0.817878841224679 -0.201041069211878 40 3 0.00527240773286467 569 5312 6777,6850,4609 STAT5B,SYK,MYC WP550 Biogenic Amine Synthesis 0.837242306469277 -0.177641756398383 16 1 0.00175746924428822 569 5312 4128 MAOA WP501 GPCRs, Class C Metabotropic glutamate, pheromone 0.837242306469277 -0.177641756398383 16 1 0.00175746924428822 569 5312 51704 GPRC5B WP3644 NAD+ metabolism 0.837242306469277 -0.177641756398383 16 1 0.00175746924428822 569 5312 349565 NMNAT3 WP2453 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) 0.837242306469277 -0.177641756398383 16 1 0.00175746924428822 569 5312 48 ACO1 WP3851 TLR4 Signaling and Tolerance 0.847132046134928 -0.165898697856538 30 2 0.00351493848857645 569 5312 1147,7099 CHUK,TLR4 WP129 Matrix Metalloproteinases 0.847132046134928 -0.165898697856538 30 2 0.00351493848857645 569 5312 4324,4325 MMP15,MMP16 WP98 Prostaglandin Synthesis and Regulation 0.847132046134928 -0.165898697856538 30 2 0.00351493848857645 569 5312 3248,5321 HPGD,PLA2G4A WP3678 Amplification and Expansion of Oncogenic Pathways as Metastatic Traits 0.854728924225054 -0.156970908005616 17 1 0.00175746924428822 569 5312 83439 TCF7L1 WP408 Oxidative Stress 0.860013422939577 -0.150807281787113 31 2 0.00351493848857645 569 5312 4128,5602 MAOA,MAPK10 WP34 Ovarian Infertility Genes 0.871895055947486 -0.137086210999718 32 2 0.00351493848857645 569 5312 1051,4088 CEBPB,SMAD3 WP2828 Bladder Cancer 0.871895055947486 -0.137086210999718 32 2 0.00351493848857645 569 5312 1890,4609 TYMP,MYC WP707 DNA Damage Response 0.875794454761131 -0.132623856261819 69 5 0.00878734622144113 569 5312 27113,27244,5366,4609,2810 BBC3,SESN1,PMAIP1,MYC,SFN WP2363 Gastric Cancer Network 2 0.882842883194773 -0.124608029437286 33 2 0.00351493848857645 569 5312 1299,4609 COL9A3,MYC WP697 Estrogen metabolism 0.884275641679952 -0.122986453092558 19 1 0.00175746924428822 569 5312 1545 CYP1B1 WP1971 Integrated Cancer Pathway 0.884310458610801 -0.122947080476378 46 3 0.00527240773286467 569 5312 4088,27113,4609 SMAD3,BBC3,MYC WP1601 Fluoropyrimidine Activity 0.892920214047779 -0.11325804806836 34 2 0.00351493848857645 569 5312 1890,10257 TYMP,ABCC4 WP2371 Parkinsons Disease Pathway 0.8930200275548 -0.113146271084113 83 6 0.0105448154657293 569 5312 2861,5071,5603,5413,120892,6622 GPR37,PRKN,MAPK13,SEPT5,LRRK2,SNCA WP391 Mitochondrial Gene Expression 0.896716064855426 -0.109016005654979 20 1 0.00175746924428822 569 5312 10891 PPARGC1A WP2533 Glycerophospholipid Biosynthetic Pathway 0.907821234747649 -0.0967077977950906 21 1 0.00175746924428822 569 5312 10400 PEMT WP691 Tamoxifen metabolism 0.907821234747649 -0.0967077977950906 21 1 0.00175746924428822 569 5312 1545 CYP1B1 WP2377 Integrated Pancreatic Cancer Pathway 0.909954532358754 -0.0943606451604354 197 16 0.0281195079086116 569 5312 5058,5563,5321,627,5163,1630,4609,7132,27113,5596,1147,5578,4091,4661,2260,3486 PAK1,PRKAA2,PLA2G4A,BDNF,PDK1,DCC,MYC,TNFRSF1A,BBC3,MAPK4,CHUK,PRKCA,SMAD6,MYT1,FGFR1,IGFBP3 WP61 Notch Signaling Pathway 0.911453204476037 -0.0927150252092473 62 4 0.0070298769771529 569 5312 2625,9253,4609,23462 GATA3,NUMBL,MYC,HEY1 WP1984 Integrated Breast Cancer Pathway 0.911730780597236 -0.0924105292004888 154 12 0.0210896309314587 569 5312 5058,2241,23077,659,4609,1147,657,4661,4091,5569,27145,3156 PAK1,FER,MYCBP2,BMPR2,MYC,CHUK,BMPR1A,MYT1,SMAD6,PKIA,FILIP1,HMGCR WP272 Blood Clotting Cascade 0.917734241261504 -0.0858474278106354 22 1 0.00175746924428822 569 5312 2161 F12 WP1584 Type II diabetes mellitus 0.917734241261504 -0.0858474278106354 22 1 0.00175746924428822 569 5312 5580 PRKCD WP3646 Hepatitis C and Hepatocellular Carcinoma 0.922182313108169 -0.0810123384130033 51 3 0.00527240773286467 569 5312 4088,2017,4609 SMAD3,CTTN,MYC WP3611 Photodynamic therapy-induced AP-1 survival signaling. 0.922182313108169 -0.0810123384130033 51 3 0.00527240773286467 569 5312 5603,5608,7132 MAPK13,MAP2K6,TNFRSF1A WP2447 Amyotrophic lateral sclerosis (ALS) 0.925689793574356 -0.0772160965997037 38 2 0.00351493848857645 569 5312 5608,7132 MAP2K6,TNFRSF1A WP2029 Cell Differentiation - Index 0.925689793574356 -0.0772160965997037 38 2 0.00351493848857645 569 5312 100271849,4208 MEF2B,MEF2C WP712 Estrogen signaling pathway 0.926582864468758 -0.076251799081487 23 1 0.00175746924428822 569 5312 1147 CHUK WP138 Androgen receptor signaling pathway 0.931051184035162 -0.0714410257348994 90 6 0.0105448154657293 569 5312 4088,8611,10399,860,11034,2274 SMAD3,PLPP1,RACK1,RUNX2,DSTN,FHL2 WP170 Nuclear Receptors 0.932262355291476 -0.0701410068155603 39 2 0.00351493848857645 569 5312 4919,3164 ROR1,NR4A1 WP107 Translation Factors 0.933865934317931 -0.0684223903302059 53 3 0.00527240773286467 569 5312 1938,1978,10209 EEF2,EIF4EBP1,EIF1 WP1533 Vitamin B12 Metabolism 0.933865934317931 -0.0684223903302059 53 3 0.00527240773286467 569 5312 875,3949,1491 CBS,LDLR,CTH WP2509 Nanoparticle triggered autophagic cell death 0.934481210112727 -0.0677637591771334 24 1 0.00175746924428822 569 5312 9474 ATG5 WP1539 Angiogenesis 0.934481210112727 -0.0677637591771334 24 1 0.00175746924428822 569 5312 4846 NOS3 WP2328 Allograft Rejection 0.940516434459252 -0.0613261562212063 80 5 0.00878734622144113 569 5312 643,7431,958,720,120892 CXCR5,VIM,CD40,C4A,LRRK2 WP1530 miRNA Regulation of DNA Damage Response 0.943312525268718 -0.058357635275272 93 6 0.0105448154657293 569 5312 27113,900,27244,5366,4609,2810 BBC3,CCNG1,SESN1,PMAIP1,MYC,SFN WP231 TNF alpha Signaling Pathway 0.946944613274283 -0.0545146740172503 94 6 0.0105448154657293 569 5312 1147,5790,5608,5966,8945,7132 CHUK,PTPRCAP,MAP2K6,REL,BTRC,TNFRSF1A WP176 Folate Metabolism 0.94733944456688 -0.0540978080285617 69 4 0.0070298769771529 569 5312 875,1435,3949,1491 CBS,CSF1,LDLR,CTH WP2369 Histone Modifications 0.94733944456688 -0.0540978080285617 69 4 0.0070298769771529 569 5312 26040,64324,83852,64754 SETBP1,NSD1,SETDB2,SMYD3 WP117 GPCRs, Other 0.950366848213521 -0.0509072129123634 95 6 0.0105448154657293 569 5312 3363,11245,9620,1951,23266,1131 HTR7,GPR176,CELSR1,CELSR3,ADGRL2,CHRM3 WP2911 miRNA targets in ECM and membrane receptors 0.953441735099266 -0.0476769621545466 43 2 0.00351493848857645 569 5312 1292,2335 COL6A2,FN1 WP364 IL-6 signaling pathway 0.953441735099266 -0.0476769621545466 43 2 0.00351493848857645 569 5312 639,5580 PRDM1,PRKCD WP314 Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation 0.957651821360753 -0.0432710103287827 44 2 0.00351493848857645 569 5312 9261,5058 MAPKAPK2,PAK1 WP716 Vitamin A and Carotenoid Metabolism 0.957651821360753 -0.0432710103287827 44 2 0.00351493848857645 569 5312 9227,1592 LRAT,CYP26A1 WP2249 Metastatic brain tumor 0.958452916130205 -0.042434840154519 28 1 0.00175746924428822 569 5312 4609 MYC WP2361 Gastric Cancer Network 1 0.958452916130205 -0.042434840154519 28 1 0.00175746924428822 569 5312 8900 CCNA1 WP2059 Alzheimers Disease 0.963691756236378 -0.0369837904456193 148 10 0.0175746924428823 569 5312 2597,23621,322,2081,7132,2906,3709,23236,4311,6622 GAPDH,BACE1,APBB1,ERN1,TNFRSF1A,GRIN2D,ITPR2,PLCB1,MME,SNCA WP24 Peptide GPCRs 0.964211643762299 -0.0364444609973459 74 4 0.0070298769771529 569 5312 643,5021,7253,10396 CXCR5,OXTR,TSHR,ATP8A1 WP268 Notch Signaling Pathway 0.965004583057377 -0.0356224283721731 46 2 0.00351493848857645 569 5312 9253,1488 NUMBL,CTBP2 WP241 One Carbon Metabolism 0.966919779001705 -0.0336397456032911 30 1 0.00175746924428822 569 5312 10840 ALDH1L1 WP143 Fatty Acid Beta Oxidation 0.979034511499213 -0.0211883852862219 34 1 0.00175746924428822 569 5312 2180 ACSL1 WP45 G1 to S cell cycle control 0.981618899916294 -0.0185521315773414 68 3 0.00527240773286467 569 5312 4661,4609,8900 MYT1,MYC,CCNA1 WP623 Oxidative phosphorylation 0.983900080405324 -0.0162309313893878 54 2 0.00351493848857645 569 5312 56901,4714 NDUFA4L2,NDUFB8 WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway 0.991587971223144 -0.00844760956920087 42 1 0.00175746924428822 569 5312 1147 CHUK WP405 Eukaryotic Transcription Initiation 0.991587971223144 -0.00844760956920087 42 1 0.00175746924428822 569 5312 2963 GTF2F2 WP183 Proteasome Degradation 0.995137812052864 -0.00487404683867429 66 2 0.00351493848857645 569 5312 7347,4734 UCHL3,NEDD4 WP1545 miRNAs involved in DNA damage response 0.996629779889254 -0.00337591209496784 50 1 0.00175746924428822 569 5312 4609 MYC WP179 Cell Cycle 0.997355392621705 -0.00264811053005819 105 4 0.0070298769771529 569 5312 4088,8555,8900,11138 SMAD3,CDC14B,CCNA1,TBC1D8 WP111 Electron Transport Chain 0.997980633136309 -0.00202140853400621 92 3 0.00527240773286467 569 5312 93974,9481,4714 ATP5IF1,SLC25A27,NDUFB8 WP2446 Retinoblastoma (RB) in Cancer 0.999496298290762 -0.00050382860955944 88 2 0.00351493848857645 569 5312 5603,4609 MAPK13,MYC WP455 GPCRs, Class A Rhodopsin-like 0.999706355037237 -0.000293688084886887 259 13 0.0228471001757469 569 5312 2861,643,81491,3363,2838,8477,23596,153,5028,5021,2842,23432,1131 GPR37,CXCR5,GPR63,HTR7,GPR15,GPR65,OPN3,ADRB1,P2RY1,OXTR,GPR19,GPR161,CHRM3 WP1438 Influenza A virus infection 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2816 Felbamate Metabolism 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP1273 Folic Acid Network 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP1311 Folic Acid Network 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2646 Lidocaine metabolism 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2901 Gonadotropin-releasing hormone (GnRH) signaling 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2866 mir34a and TGIF2 in osteoclastogenesis 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2943 Hypoxia-mediated EMT and Stemness 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP2366 Butyrate-induced histone acetylation 0.9999999999886 -1.13999747142213e-11 2 0 0 569 5312 WP704 Methylation Pathways 0.99999999999018 -9.8200511665248e-12 10 0 0 569 5312 WP2113 Type III interferon signaling 0.99999999999018 -9.8200511665248e-12 10 0 0 569 5312 WP496 Steroid Biosynthesis 0.99999999999018 -9.8200511665248e-12 10 0 0 569 5312 WP311 Synthesis and Degradation of Ketone Bodies 0.9999999999904 -9.59950922835892e-12 5 0 0 569 5312 WP2868 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer 0.9999999999904 -9.59950922835892e-12 5 0 0 569 5312 WP2597 Secretion of Hydrochloric Acid in Parietal Cells 0.9999999999904 -9.59950922835892e-12 5 0 0 569 5312 WP2190 One carbon donor 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP1 Statin Pathway 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP188 Focal Adhesion 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP3191 TSLP Signaling Pathway 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP3627 Gut-Liver Indole Metabolism 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP108 Selenium metabolism/Selenoproteins 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP661 Glucose Homeostasis 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP2536 Colchicine Metabolic Pathway 0.999999999991739 -8.26086421490402e-12 1 0 0 569 5312 WP2596 Gastric acid production 0.999999999993369 -6.63107331823835e-12 7 0 0 569 5312 WP134 Pentose Phosphate Pathway 0.999999999993369 -6.63107331823835e-12 7 0 0 569 5312 WP699 Aflatoxin B1 metabolism 0.999999999993369 -6.63107331823835e-12 7 0 0 569 5312 WP2805 RNA interference 0.999999999993369 -6.63107331823835e-12 7 0 0 569 5312 WP438 Non-homologous end joining 0.999999999993369 -6.63107331823835e-12 7 0 0 569 5312 WP2491 Diclofenac Metabolic Pathway 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP3633 Caffeine and Theobromine metabolism 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP1941 Peroxisomal beta-oxidation of tetracosanoyl-CoA 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP690 Polyol Pathway 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP733 Serotonin Receptor 2 and STAT3 Signaling 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP3302 eIF5A regulation in response to inhibition of the nuclear export system 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP521 Amino acid conjugation of benzoic acid 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP2253 Pilocytic astrocytoma 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP1603 Nicotine Activity on Chromaffin Cells 0.999999999993733 -6.26661721646327e-12 4 0 0 569 5312 WP694 Arylamine metabolism 0.999999999995581 -4.41917448501763e-12 6 0 0 569 5312 WP1600 Nicotine Metabolism 0.999999999995581 -4.41917448501763e-12 6 0 0 569 5312 WP3891 Benzene metabolism 0.999999999995581 -4.41917448501763e-12 6 0 0 569 5312 WP2854 Gene regulatory network modelling somitogenesis 0.999999999997225 -2.77470032900637e-12 11 0 0 569 5312 WP3630 NAD metabolism, sirtuins and aging 0.999999999997225 -2.77470032900637e-12 11 0 0 569 5312 WP2435 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis 0.999999999999311 -6.89360304776664e-13 15 0 0 569 5312 WP2507 Nanomaterial induced apoptosis 1.00000000000161 1.61182805975352e-12 21 0 0 569 5312 WP3875 ATR Signaling 1.00000000000482 4.81809830737899e-12 9 0 0 569 5312 WP3300 Dual hijack model of Vif in HIV infection 1.00000000000482 4.81809830737899e-12 9 0 0 569 5312 WP2942 DDX1 as a regulatory component of the Drosha microprocessor 1.00000000000482 4.81809830737899e-12 9 0 0 569 5312 WP531 Mismatch repair 1.00000000000482 4.81809830737899e-12 9 0 0 569 5312 WP3585 Cytosine methylation 1.00000000000482 4.81809830737899e-12 9 0 0 569 5312 WP1559 TFs Regulate miRNAs related to cardiac hypertrophy 1.00000000000576 5.76058774067443e-12 12 0 0 569 5312 WP2276 Glial Cell Differentiation 1.00000000000705 7.04508861328727e-12 8 0 0 569 5312 WP2338 miRNA Biogenesis 1.00000000000705 7.04508861328727e-12 8 0 0 569 5312 WP237 Glucocorticoid & Mineralcorticoid Metabolism 1.00000000000705 7.04508861328727e-12 8 0 0 569 5312 WP3657 Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex 1.00000000000889 8.8886539825309e-12 22 0 0 569 5312 WP78 TCA Cycle 1.00000000001287 1.28716813804377e-11 17 0 0 569 5312 WP2916 Interactome of polycomb repressive complex 2 (PRC2) 1.00000000001287 1.28716813804377e-11 17 0 0 569 5312 WP404 Nucleotide Metabolism 1.00000000001301 1.30143108353913e-11 19 0 0 569 5312 WP1992 TarBasePathway 1.00000000001301 1.30143108353913e-11 19 0 0 569 5312 WP247 Small Ligand GPCRs 1.00000000001301 1.30143108353913e-11 19 0 0 569 5312 WP186 Homologous recombination 1.00000000001428 1.42795587202827e-11 13 0 0 569 5312 WP2516 ATM Signaling Pathway 1.00000000001619 1.61898933879232e-11 40 0 0 569 5312 WP411 mRNA Processing 1.00000000001641 1.64056849764016e-11 132 0 0 569 5312 WP3413 NOTCH1 regulation of human endothelial cell calcification 1.00000000001657 1.65734689299003e-11 18 0 0 569 5312 WP692 Sulfation Biotransformation Reaction 1.00000000001657 1.65734689299003e-11 18 0 0 569 5312 WP2865 IL1 and megakaryocytes in obesity 1.0000000000166 1.66045051146674e-11 25 0 0 569 5312 WP3878 ATM Signaling Network in Development and Disease 1.000000000021 2.10016139184148e-11 46 0 0 569 5312 WP3414 Initiation of transcription and translation elongation at the HIV-1 LTR 1.00000000002397 2.39652657138289e-11 37 0 0 569 5312 WP466 DNA Replication 1.00000000002787 2.78684903104446e-11 42 0 0 569 5312