TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols META_PWY66-398 TCA cycle III (animals) 0.000447649134616136 -7.71150081405668 16 9 0.0573248407643312 157 902 6390,8802,3419,4191,1431,8801,4190,4967,6389 SDHB,SUCLG1,IDH3A,MDH2,CS,SUCLG2,MDH1,OGDH,SDHA HUMAN_PWY66-398 TCA cycle 0.000447649134616136 -7.71150081405668 16 9 0.0573248407643312 157 902 6390,8802,3419,4191,1431,8801,4190,4967,6389 SDHB,SUCLG1,IDH3A,MDH2,CS,SUCLG2,MDH1,OGDH,SDHA META_PWY-841 superpathway of purine nucleotides de novo biosynthesis I 0.0149250732518511 -4.20471271171879 13 6 0.0382165605095541 157 902 3614,6241,2618,2987,471,6240 IMPDH1,RRM2,GART,GUK1,ATIC,RRM1 HUMAN_MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 0.0180934511149842 -4.01220522303357 4 3 0.0191082802547771 157 902 4190,2806,4191 MDH1,GOT2,MDH2 META_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.0301365076006086 -3.5020179650719 2 2 0.0127388535031847 157 902 54187,140838 NANS,NANP HUMAN_PWY-5481 lactate fermentation (reoxidation of cytosolic NADH) 0.0301365076006086 -3.5020179650719 2 2 0.0127388535031847 157 902 3939,3945 LDHA,LDHB HUMAN_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.0301365076006086 -3.5020179650719 2 2 0.0127388535031847 157 902 55907,54187 CMAS,NANS META_PWY-6145 superpathway of CMP-sialic acids biosynthesis 0.0301365076006086 -3.5020179650719 2 2 0.0127388535031847 157 902 54187,140838 NANS,NANP HUMAN_PWY-5667 CDP-diacylglycerol biosynthesis 0.0332824858570696 -3.40272397059423 19 7 0.0445859872611465 157 902 56894,8760,10555,253558,254531,51099,10554 AGPAT3,CDS2,AGPAT2,LCLAT1,LPCAT4,ABHD5,AGPAT1 META_PWY-7228 superpathway of guanosine nucleotides de novo biosynthesis I 0.0348247356268962 -3.35742735081971 8 4 0.0254777070063694 157 902 3614,6241,2987,6240 IMPDH1,RRM2,GUK1,RRM1 HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle 0.034856078161271 -3.35652774776444 36 11 0.0700636942675159 157 902 6390,8802,3419,4191,1431,8801,4190,4967,5315,6389,5214 SDHB,SUCLG1,IDH3A,MDH2,CS,SUCLG2,MDH1,OGDH,PKM,SDHA,PFKP META_PWY-5667 CDP-diacylglycerol biosynthesis I 0.0394743786337283 -3.23210345971851 5 3 0.0191082802547771 157 902 56894,10555,10554 AGPAT3,AGPAT2,AGPAT1 META_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.0543471694313217 -2.91236274715161 9 4 0.0254777070063694 157 902 6241,1635,84284,6240 RRM2,DCTD,NTPCR,RRM1 HUMAN_PWY-7527 methionine salvage cycle III 0.0543471694313217 -2.91236274715161 9 4 0.0254777070063694 157 902 27430,6723,84245,4144 MAT2B,SRM,MRI1,MAT2A META_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I 0.0543471694313217 -2.91236274715161 9 4 0.0254777070063694 157 902 6241,84284,1854,6240 RRM2,NTPCR,DUT,RRM1 META_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.0587846468986227 -2.83387456533825 13 5 0.0318471337579618 157 902 6241,84284,1854,1503,6240 RRM2,NTPCR,DUT,CTPS1,RRM1 HUMAN_PWY-7193 pyrimidine ribonucleosides salvage I 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 83549,7371 UCK1,UCK2 META_ARGININE-SYN4-PWY L-ornithine biosynthesis II 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 4942,5832 OAT,ALDH18A1 META_MALATE-ASPARTATE-SHUTTLE-PWY L-aspartate degradation II 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 4190,4191 MDH1,MDH2 HUMAN_PWY-7185 UTP and CTP dephosphorylation I 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 84284,1503 NTPCR,CTPS1 HUMAN_METHIONINE-DEG1-PWY methionine degradation 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 27430,4144 MAT2B,MAT2A META_PWY-2301 myo-inositol biosynthesis 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 54928,3613 IMPAD1,IMPA2 META_PWY-7193 pyrimidine ribonucleosides salvage I 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 83549,7371 UCK1,UCK2 HUMAN_GLUAMCAT-PWY N-acetylglucosamine degradation I 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 51005,10007 AMDHD2,GNPDA1 HUMAN_ARGININE-SYN4-PWY ornithine de novo biosynthesis 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 5832,4942 ALDH18A1,OAT HUMAN_SAM-PWY S-adenosyl-L-methionine biosynthesis 0.0800291701836229 -2.52536408347335 3 2 0.0127388535031847 157 902 27430,4144 MAT2B,MAT2A HUMAN_PWY-841 purine nucleotides de novo biosynthesis 0.0921206341887892 -2.38465631967657 37 10 0.0636942675159236 157 902 159,2618,2987,471,6240,3614,6241,498,506,9551 ADSS,GART,GUK1,ATIC,RRM1,IMPDH1,RRM2,ATP5F1A,ATP5F1B,ATP5MF HUMAN_PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 0.105656942692713 -2.24755782299762 7 3 0.0191082802547771 157 902 6675,64841,10007 UAP1,GNPNAT1,GNPDA1 HUMAN_PWY-7511 protein ubiquitylation 0.114185185253584 -2.1699337165013 29 8 0.0509554140127389 157 902 7323,55585,65264,92912,7325,55293,79876,134111 UBE2D3,UBE2Q1,UBE2Z,UBE2Q2,UBE2E2,UEVLD,UBA5,UBE2QL1 META_PWY66-368 ketolysis 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 38,622 ACAT1,BDH1 META_PWY66-423 fructose 2,6-bisphosphate biosynthesis 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 5209,57103 PFKFB3,TIGAR META_PWY-3781 aerobic respiration I (cytochrome c) 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 6390,6389 SDHB,SDHA HUMAN_PWY66-368 ketolysis 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 38,622 ACAT1,BDH1 HUMAN_PWY-7177 UTP and CTP dephosphorylation II 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 124583,1503 CANT1,CTPS1 HUMAN_PWY-6292 cysteine biosynthesis 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 27430,4144 MAT2B,MAT2A META_POLYAMINSYN3-PWY superpathway of polyamine biosynthesis II 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 6723,4953 SRM,ODC1 HUMAN_PWY66-423 fructose 2,6-bisphosphate synthesis 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 5209,57103 PFKFB3,TIGAR HUMAN_PWY-6517 N-acetylglucosamine degradation II 0.141964889254255 -1.95217551072722 4 2 0.0127388535031847 157 902 51005,10007 AMDHD2,GNPDA1 HUMAN_PWY-7434 terminal O-glycans residues modification 0.148156266932408 -1.90948770459225 8 3 0.0191082802547771 157 902 8128,8703,8704 ST8SIA2,B4GALT3,B4GALT2 META_PWY-7625 phosphatidylinositol biosynthesis II (eukaryotes) 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 10423 CDIPT HUMAN_PWY-6405 Rapoport-Luebering glycolytic shunt 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9562 MINPP1 META_PWY-46 putrescine biosynthesis III 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 4953 ODC1 HUMAN_PWY-5120 geranylgeranyldiphosphate biosynthesis 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9453 GGPS1 META_PWY-6938 NADH repair 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 128240 NAXE META_PWY-5120 geranylgeranyl diphosphate biosynthesis 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9453 GGPS1 HUMAN_PWY-7592 arachidonate biosynthesis III (metazoa) 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 60481 ELOVL5 HUMAN_PWY66-366 flavin biosynthesis 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 80308 FLAD1 HUMAN_PWY-6938 NADH repair 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 128240 NAXE HUMAN_BSUBPOLYAMSYN-PWY spermidine biosynthesis 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 6723 SRM META_PWY-7501 phosphatidylserine biosynthesis I 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9791 PTDSS1 HUMAN_PWY-46 putrescine biosynthesis I 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 4953 ODC1 HUMAN_PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 7264 TSTA3 META_PWY-5172 acetyl-CoA biosynthesis III (from citrate) 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 47 ACLY HUMAN_PWY-7501 phosphatidylserine biosynthesis I 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9791 PTDSS1 HUMAN_SERSYN-PWY serine biosynthesis (phosphorylated route) 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 51699 VPS29 META_PWY-5269 cardiolipin biosynthesis II 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 9489 PGS1 HUMAN_PWY-5172 acetyl-CoA biosynthesis from citrate 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 47 ACLY HUMAN_PWY66-11 BMP Signalling Pathway 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 4089 SMAD4 META_BSUBPOLYAMSYN-PWY spermidine biosynthesis I 0.174057649667532 -1.74836871471359 1 1 0.00636942675159236 157 902 6723 SRM META_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.17615758000533 -1.73637634358322 13 4 0.0254777070063694 157 902 10423,5305,23396,55361 CDIPT,PIP4K2A,PIP5K1C,PI4K2A META_PWY66-409 superpathway of purine nucleotide salvage 0.17615758000533 -1.73637634358322 13 4 0.0254777070063694 157 902 3614,6241,2987,6240 IMPDH1,RRM2,GUK1,RRM1 META_PWY66-5 superpathway of cholesterol biosynthesis 0.196800052926557 -1.62556702542826 23 6 0.0382165605095541 157 902 38,9453,10654,50814,2222,10682 ACAT1,GGPS1,PMVK,NSDHL,FDFT1,EBP HUMAN_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.196800052926557 -1.62556702542826 23 6 0.0382165605095541 157 902 10423,5305,55361,51259,79837,23396 CDIPT,PIP4K2A,PI4K2A,TMEM216,PIP4K2C,PIP5K1C META_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 6241,6240 RRM2,RRM1 META_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 7083,1633 TK1,DCK META_PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 60481,51 ELOVL5,ACOX1 META_CITRULBIO-PWY L-citrulline biosynthesis 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 4942,5832 OAT,ALDH18A1 HUMAN_COA-PWY-1 coenzyme A biosynthesis 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 79717,60490 PPCS,PPCDC HUMAN_PWY66-367 ketogenesis 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 38,622 ACAT1,BDH1 META_PWY-7726 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis (6-desaturase) 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 60481,51 ELOVL5,ACOX1 HUMAN_PLPSAL-PWY pyridoxal 5'-phosphate salvage 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 57026,8566 PDXP,PDXK HUMAN_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 6675,64841 UAP1,GNPNAT1 META_COA-PWY-1 coenzyme A biosynthesis II (mammalian) 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 79717,60490 PPCS,PPCDC META_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 6241,6240 RRM2,RRM1 HUMAN_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.210291896335366 -1.55925873084681 5 2 0.0127388535031847 157 902 7083,1633 TK1,DCK HUMAN_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis 0.215026636818482 -1.53699336634949 14 4 0.0254777070063694 157 902 6241,84284,1854,6240 RRM2,NTPCR,DUT,RRM1 HUMAN_PWY-7228 guanosine nucleotides de novo biosynthesis 0.215026636818482 -1.53699336634949 14 4 0.0254777070063694 157 902 3614,6241,2987,6240 IMPDH1,RRM2,GUK1,RRM1 HUMAN_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.215026636818482 -1.53699336634949 14 4 0.0254777070063694 157 902 6241,1635,84284,6240 RRM2,DCTD,NTPCR,RRM1 META_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.223588406032079 -1.49794839042263 19 5 0.0318471337579618 157 902 9562,3632,5728,54928,3613 MINPP1,INPP5A,PTEN,IMPAD1,IMPA2 HUMAN_PWY-7049 icosapentaenoate biosynthesis II (metazoa) 0.244966775328567 -1.40663268853721 10 3 0.0191082802547771 157 902 51703,60481,2181 ACSL5,ELOVL5,ACSL3 HUMAN_PWY66-5 superpathway of cholesterol biosynthesis 0.258358596091303 -1.35340675175699 25 6 0.0382165605095541 157 902 38,9453,10654,50814,2222,10682 ACAT1,GGPS1,PMVK,NSDHL,FDFT1,EBP HUMAN_TRIGLSYN-PWY triacylglycerol biosynthesis 0.258358596091303 -1.35340675175699 25 6 0.0382165605095541 157 902 56894,10555,253558,254531,51099,10554 AGPAT3,AGPAT2,LCLAT1,LPCAT4,ABHD5,AGPAT1 HUMAN_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.258963895140733 -1.35106662800085 20 5 0.0318471337579618 157 902 9562,3632,5728,54928,3613 MINPP1,INPP5A,PTEN,IMPAD1,IMPA2 HUMAN_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.258963895140733 -1.35106662800085 20 5 0.0318471337579618 157 902 6241,84284,1854,1503,6240 RRM2,NTPCR,DUT,CTPS1,RRM1 META_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.280942174002472 -1.2696064172934 6 2 0.0127388535031847 157 902 3614,2987 IMPDH1,GUK1 META_PWY66-367 ketogenesis 0.280942174002472 -1.2696064172934 6 2 0.0127388535031847 157 902 38,622 ACAT1,BDH1 HUMAN_PWY3O-450 phosphatidylcholine biosynthesis 0.280942174002472 -1.2696064172934 6 2 0.0127388535031847 157 902 56994,1119 CHPT1,CHKA HUMAN_PWY-5143 fatty acid activation 0.280942174002472 -1.2696064172934 6 2 0.0127388535031847 157 902 51703,2181 ACSL5,ACSL3 META_PWY-7229 superpathway of adenosine nucleotides de novo biosynthesis I 0.280942174002472 -1.2696064172934 6 2 0.0127388535031847 157 902 6241,6240 RRM2,RRM1 META_PWY66-341 cholesterol biosynthesis I 0.296579160723806 -1.21544111228679 11 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP META_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.296579160723806 -1.21544111228679 11 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP META_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.296579160723806 -1.21544111228679 11 3 0.0191082802547771 157 902 3632,54928,3613 INPP5A,IMPAD1,IMPA2 META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.296579160723806 -1.21544111228679 11 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP HUMAN_PWY0-662 PRPP biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 5634 PRPS2 META_PWY-4041 gamma-glutamyl cycle 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2730 GCLM HUMAN_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2618 GART META_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2618 GART META_PWY-7437 protein O-[N-acetyl]-glucosylation 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 8473 OGT HUMAN_PROSYN-PWY proline biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 5832 ALDH18A1 META_PWY66-366 flavin biosynthesis IV (mammalian) 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 80308 FLAD1 HUMAN_PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 55253 TYW1 META_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2618 GART HUMAN_PWY-5905 hypusine biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 1725 DHPS META_PLPSAL-PWY pyridoxal 5'-phosphate salvage I 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 8566 PDXK HUMAN_PWY-7437 protein O-[N-acetyl]-glucosylation 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 8473 OGT HUMAN_PWY-5386 methylglyoxal degradation I 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2739 GLO1 META_PWY-5806 all-trans-decaprenyl diphosphate biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 57107 PDSS2 META_PWY-6124 inosine-5'-phosphate biosynthesis II 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 471 ATIC HUMAN_PWY-6124 inosine-5'-phosphate biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 471 ATIC HUMAN_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2618 GART HUMAN_PWY-5670 epoxysqualene biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2222 FDFT1 META_PROSYN-PWY L-proline biosynthesis I 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 5832 ALDH18A1 HUMAN_PWY-5269 cardiolipin biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 9489 PGS1 META_PWY0-662 PRPP biosynthesis I 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 5634 PRPS2 META_PWY-5177 glutaryl-CoA degradation 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 38 ACAT1 META_PWY-5670 epoxysqualene biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 2222 FDFT1 META_PWY-5453 methylglyoxal degradation III 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 231 AKR1B1 META_PWY-7343 UDP-glucose biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 7360 UGP2 HUMAN_PWY-2301 myo-inositol de novo biosynthesis 0.317978791729795 -1.14577059109962 2 1 0.00636942675159236 157 902 3613 IMPA2 HUMAN_PWY66-409 superpathway of purine nucleotide salvage 0.335854243466155 -1.0910780123449 38 8 0.0509554140127389 157 902 159,2987,6240,6241,3614,506,498,9551 ADSS,GUK1,RRM1,RRM2,IMPDH1,ATP5F1B,ATP5F1A,ATP5MF HUMAN_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.341453404415545 -1.07454405315895 17 4 0.0254777070063694 157 902 8897,5305,51259,79837 MTMR3,PIP4K2A,TMEM216,PIP4K2C META_PWY66-391 fatty acid beta-oxidation VI (peroxisome) 0.348757937180172 -1.05337718716598 12 3 0.0191082802547771 157 902 51703,51,2181 ACSL5,ACOX1,ACSL3 HUMAN_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.348757937180172 -1.05337718716598 12 3 0.0191082802547771 157 902 38,9453,10654 ACAT1,GGPS1,PMVK META_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.348757937180172 -1.05337718716598 12 3 0.0191082802547771 157 902 38,9453,10654 ACAT1,GGPS1,PMVK META_PWY-7224 purine deoxyribonucleosides salvage 0.351056266526979 -1.04680876486784 7 2 0.0127388535031847 157 902 2987,1633 GUK1,DCK HUMAN_PWY-5067 glycogen biosynthesis 0.351056266526979 -1.04680876486784 7 2 0.0127388535031847 157 902 2992,7360 GYG1,UGP2 HUMAN_PWY-6371 superpathway of inositol phosphate compounds 0.356183549826074 -1.03230909160157 66 13 0.0828025477707006 157 902 8897,5728,3632,5296,79837,51259,51447,200576,10423,9562,5305,55361,23396 MTMR3,PTEN,INPP5A,PIK3R2,PIP4K2C,TMEM216,IP6K2,PIKFYVE,CDIPT,MINPP1,PIP4K2A,PI4K2A,PIP5K1C HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.40053804433371 -0.914946524891029 13 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP HUMAN_PWY66-341 cholesterol biosynthesis I 0.40053804433371 -0.914946524891029 13 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.40053804433371 -0.914946524891029 13 3 0.0191082802547771 157 902 50814,2222,10682 NSDHL,FDFT1,EBP HUMAN_PWY66-391 fatty acid beta-oxidation (peroxisome) 0.40053804433371 -0.914946524891029 13 3 0.0191082802547771 157 902 51703,51,2181 ACSL5,ACOX1,ACSL3 HUMAN_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.40053804433371 -0.914946524891029 13 3 0.0191082802547771 157 902 3632,54928,3613 INPP5A,IMPAD1,IMPA2 META_PWY-7426 mannosyl-glycoprotein N-acetylglucosaminyltransferases 0.418689599725507 -0.870625445707848 8 2 0.0127388535031847 157 902 4122,4249 MAN2A2,MGAT5 HUMAN_PWY-0 putrescine degradation III 0.418689599725507 -0.870625445707848 8 2 0.0127388535031847 157 902 221,112483 ALDH3B1,SAT2 HUMAN_PWY-2201 folate transformations I 0.418689599725507 -0.870625445707848 8 2 0.0127388535031847 157 902 10797,4548 MTHFD2,MTR HUMAN_PWY-7219 adenosine ribonucleotides de novo biosynthesis 0.427748908533826 -0.849218917858149 19 4 0.0254777070063694 157 902 159,498,506,9551 ADSS,ATP5F1A,ATP5F1B,ATP5MF META_ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 4548 MTR HUMAN_PWY-5331 taurine biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 84890 ADO META_PWY-5664 tetrahydrobiopterin biosynthesis II 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 6697 SPR META_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 4967 OGDH META_PWY-5331 taurine biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 84890 ADO HUMAN_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 9562 MINPP1 META_PWY-6405 Rapoport-Luebering glycolytic shunt 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 9562 MINPP1 HUMAN_ADENOSYLHOMOCYSCAT-PWY methionine salvage 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 4548 MTR META_PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 60481 ELOVL5 HUMAN_PWY-6100 L-carnitine biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 223 ALDH9A1 HUMAN_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 4967 OGDH META_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 9562 MINPP1 META_ARGASEDEG-PWY L-arginine degradation I (arginase pathway) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 4942 OAT META_PWY-6100 L-carnitine biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 223 ALDH9A1 META_PWY-5451 acetone degradation I (to methylglyoxal) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 231 AKR1B1 META_PWY-5663 tetrahydrobiopterin biosynthesis I 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 6697 SPR HUMAN_PWY66-385 dTMP de novo biosynthesis (mitochondrial) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 200895 DHFR2 HUMAN_PWY-5663 tetrahydrobiopterin de novo biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 6697 SPR META_PWY66-162 ethanol degradation IV 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 847 CAT META_PWY-7177 UTP and CTP dephosphorylation II 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 1503 CTPS1 META_PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 60481 ELOVL5 META_PWY-7527 L-methionine salvage cycle III 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 6723 SRM META_HEME-BIOSYNTHESIS-II heme biosynthesis I (aerobic) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 1371 CPOX META_PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 60481 ELOVL5 HUMAN_NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 7086 TKT META_PWY-7466 acetone degradation III (to propane-1,2-diol) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 231 AKR1B1 HUMAN_HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 1371 CPOX META_PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 60481 ELOVL5 HUMAN_PWY-5453 methylglyoxal degradation III 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 231 AKR1B1 HUMAN_PWY-7283 wybutosine biosynthesis 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 55253 TYW1 HUMAN_PWY-7606 docosahexaenoate biosynthesis III (mammals) 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 60481 ELOVL5 META_PWY-7185 UTP and CTP dephosphorylation I 0.436953602508759 -0.827928262272108 3 1 0.00636942675159236 157 902 1503 CTPS1 META_PWY-6352 3-phosphoinositide biosynthesis 0.446247331494325 -0.806881925750817 25 5 0.0318471337579618 157 902 200576,10423,5296,23396,55361 PIKFYVE,CDIPT,PIK3R2,PIP5K1C,PI4K2A HUMAN_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.446247331494325 -0.806881925750817 25 5 0.0318471337579618 157 902 56913,6483,2590,55568,51809 C1GALT1,ST3GAL2,GALNT2,GALNT10,GALNT7 META_FAO-PWY fatty acid beta-oxidation I 0.451132064565458 -0.79599515625716 14 3 0.0191082802547771 157 902 51703,2181,3032 ACSL5,ACSL3,HADHB HUMAN_FAO-PWY fatty acid beta-oxidation 0.451132064565458 -0.79599515625716 14 3 0.0191082802547771 157 902 51703,2181,3032 ACSL5,ACSL3,HADHB META_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.482583538023997 -0.72860123738834 9 2 0.0127388535031847 157 902 8897,5305 MTMR3,PIP4K2A HUMAN_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.499921868610611 -0.693303455549023 15 3 0.0191082802547771 157 902 9562,3632,5728 MINPP1,INPP5A,PTEN META_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.499921868610611 -0.693303455549023 15 3 0.0191082802547771 157 902 9562,3632,5728 MINPP1,INPP5A,PTEN HUMAN_PWY-6352 3-phosphoinositide biosynthesis 0.519351553107454 -0.65517425882958 27 5 0.0318471337579618 157 902 200576,10423,5296,55361,23396 PIKFYVE,CDIPT,PIK3R2,PI4K2A,PIP5K1C HUMAN_HYDROXYPRODEG-PWY 4-hydroxyproline degradation 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 2806 GOT2 HUMAN_PWY-6117 spermine and spermidine degradation I 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 112483 SAT2 HUMAN_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 9453 GGPS1 HUMAN_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 84245 MRI1 META_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 9453 GGPS1 HUMAN_PWY-5177 glutaryl-CoA degradation 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 38 ACAT1 META_PWY-5067 glycogen biosynthesis II (from UDP-D-Glucose) 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 2992 GYG1 META_HYDROXYPRODEG-PWY trans-4-hydroxy-L-proline degradation I 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 2806 GOT2 META_PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 60481 ELOVL5 HUMAN_PWY-6755 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 84245 MRI1 META_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 55191 NADSYN1 HUMAN_SER-GLYSYN-PWY serine and glycine biosynthesis 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 51699 VPS29 HUMAN_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 55191 NADSYN1 HUMAN_PWY66-162 ethanol degradation IV 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 847 CAT HUMAN_PWY-5872 ubiquinol-10 biosynthesis 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 57107 PDSS2 META_PWY-5872 ubiquinol-10 biosynthesis (eukaryotic) 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 57107 PDSS2 HUMAN_THIOREDOX-PWY thioredoxin pathway 0.535283173596861 -0.624959375671354 4 1 0.00636942675159236 157 902 25824 PRDX5 META_PWY-922 mevalonate pathway I 0.541987728698897 -0.61251191857574 10 2 0.0127388535031847 157 902 38,10654 ACAT1,PMVK HUMAN_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.541987728698897 -0.61251191857574 10 2 0.0127388535031847 157 902 6241,6240 RRM2,RRM1 META_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.541987728698897 -0.61251191857574 10 2 0.0127388535031847 157 902 7083,1633 TK1,DCK HUMAN_PWY-922 mevalonate pathway 0.541987728698897 -0.61251191857574 10 2 0.0127388535031847 157 902 38,10654 ACAT1,PMVK HUMAN_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis 0.541987728698897 -0.61251191857574 10 2 0.0127388535031847 157 902 6241,6240 RRM2,RRM1 META_PWY-5004 superpathway of L-citrulline metabolism 0.596522966026477 -0.516637536883601 11 2 0.0127388535031847 157 902 5832,4942 ALDH18A1,OAT HUMAN_PWY-5972 stearate biosynthesis 0.596522966026477 -0.516637536883601 11 2 0.0127388535031847 157 902 51703,2181 ACSL5,ACSL3 HUMAN_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.596522966026477 -0.516637536883601 11 2 0.0127388535031847 157 902 3614,2987 IMPDH1,GUK1 HUMAN_PWY-7224 purine deoxyribonucleosides salvage 0.596522966026477 -0.516637536883601 11 2 0.0127388535031847 157 902 2987,1633 GUK1,DCK META_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 56913 C1GALT1 HUMAN_PWY66-375 leukotriene biosynthesis 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 4048 LTA4H META_PWY66-375 leukotriene biosynthesis 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 4048 LTA4H HUMAN_PWY-7180 2'-deoxy-alpha-D-ribose 1-phosphate degradation 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 221 ALDH3B1 META_PWY-6111 mitochondrial L-carnitine shuttle 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 1384 CRAT HUMAN_PWY4FS-6 phosphatidylethanolamine biosynthesis II 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 5833 PCYT2 META_PWY-6074 zymosterol biosynthesis 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 50814 NSDHL HUMAN_PWY66-422 D-galactose degradation V (Leloir pathway) 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 2584 GALK1 HUMAN_PWY-6111 mitochondrial L-carnitine shuttle 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 1384 CRAT META_PWY-4081 glutathione-peroxide redox reactions 0.616530992914296 -0.483646685274285 5 1 0.00636942675159236 157 902 2879 GPX4 HUMAN_VALDEG-PWY valine degradation 0.646075971797489 -0.436838178712587 12 2 0.0127388535031847 157 902 27034,587 ACAD8,BCAT2 META_PWY-6857 retinol biosynthesis 0.646075971797489 -0.436838178712587 12 2 0.0127388535031847 157 902 157506,51109 RDH10,RDH11 HUMAN_LEU-DEG2-PWY leucine degradation 0.646075971797489 -0.436838178712587 12 2 0.0127388535031847 157 902 587,56922 BCAT2,MCCC1 HUMAN_ILEUDEG-PWY isoleucine degradation 0.646075971797489 -0.436838178712587 12 2 0.0127388535031847 157 902 38,587 ACAT1,BCAT2 HUMAN_PWY-6000 gamma-linolenate biosynthesis 0.646075971797489 -0.436838178712587 12 2 0.0127388535031847 157 902 51703,2181 ACSL5,ACSL3 HUMAN_PWY3DJ-12 ceramide de novo biosynthesis 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 171546 SPTSSA META_PWY3DJ-12 ceramide de novo biosynthesis 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 171546 SPTSSA META_ILEUDEG-PWY L-isoleucine degradation I 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 38 ACAT1 HUMAN_PWY-6074 zymosterol biosynthesis 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 50814 NSDHL META_PWY-7176 UTP and CTP de novo biosynthesis 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 1503 CTPS1 META_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 3614 IMPDH1 HUMAN_PENTOSE-P-PWY pentose phosphate pathway 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 7086 TKT HUMAN_PWY-4081 glutathione redox reactions I 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 2879 GPX4 META_PWY-7277 sphingolipid biosynthesis (mammals) 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 171546 SPTSSA META_PWY-5327 superpathway of L-lysine degradation 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 38 ACAT1 HUMAN_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.683648756698078 -0.380311006852151 6 1 0.00636942675159236 157 902 3614 IMPDH1 META_PWY-6861 the visual cycle I (vertebrates) 0.690719231337755 -0.370021860017616 13 2 0.0127388535031847 157 902 157506,51109 RDH10,RDH11 HUMAN_PWY-5328 superpathway of methionine degradation 0.690719231337755 -0.370021860017616 13 2 0.0127388535031847 157 902 27430,4144 MAT2B,MAT2A HUMAN_PWY3DJ-11281 sphingomyelin metabolism/ceramide salvage 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 142891 SAMD8 HUMAN_PWY66-374 C20 prostanoid biosynthesis 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 10728 PTGES3 META_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 1503 CTPS1 META_PWY66-374 C20 prostanoid biosynthesis 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 10728 PTGES3 HUMAN_PWY-6369 inositol pyrophosphates biosynthesis 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 51447 IP6K2 META_PWY-6369 inositol pyrophosphates biosynthesis 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 51447 IP6K2 META_DETOX1-PWY-1 reactive oxygen species degradation 0.739080838395233 -0.302347975118991 7 1 0.00636942675159236 157 902 847 CAT META_ANAEROFRUCAT-PWY homolactic fermentation 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 5315,5214 PKM,PFKP HUMAN_PWY66-399 gluconeogenesis 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 4190,4191 MDH1,MDH2 HUMAN_PWY-6861 the visual cycle I (vertebrates) 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 157506,51109 RDH10,RDH11 META_PWY66-399 gluconeogenesis III 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 4190,4191 MDH1,MDH2 HUMAN_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 7083,1633 TK1,DCK HUMAN_PWY66-400 glycolysis 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 5315,5214 PKM,PFKP META_ANAGLYCOLYSIS-PWY glycolysis III (from glucose) 0.766147126907399 -0.266381056004272 15 2 0.0127388535031847 157 902 5315,5214 PKM,PFKP META_PWY-5920 superpathway of heme biosynthesis from glycine 0.784851015349608 -0.242261368575566 8 1 0.00636942675159236 157 902 1371 CPOX META_LEU-DEG2-PWY L-leucine degradation I 0.784851015349608 -0.242261368575566 8 1 0.00636942675159236 157 902 56922 MCCC1 META_TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation III (eukaryotic) 0.784851015349608 -0.242261368575566 8 1 0.00636942675159236 157 902 38 ACAT1 HUMAN_PWY-5451 acetone degradation I (to methylglyoxal) 0.784851015349608 -0.242261368575566 8 1 0.00636942675159236 157 902 231 AKR1B1 HUMAN_PWY-5920 heme biosynthesis 0.784851015349608 -0.242261368575566 8 1 0.00636942675159236 157 902 1371 CPOX HUMAN_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis 0.82263445001753 -0.195243344634663 9 1 0.00636942675159236 157 902 10195 ALG3 META_NADSYN-PWY NAD biosynthesis II (from tryptophan) 0.82263445001753 -0.195243344634663 9 1 0.00636942675159236 157 902 55191 NADSYN1 META_PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 0.82263445001753 -0.195243344634663 9 1 0.00636942675159236 157 902 2806 GOT2 HUMAN_PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 0.82263445001753 -0.195243344634663 9 1 0.00636942675159236 157 902 427 ASAH1 META_PWY-6353 purine nucleotides degradation II (aerobic) 0.82263445001753 -0.195243344634663 9 1 0.00636942675159236 157 902 3614 IMPDH1 HUMAN_PWY-6857 retinol biosynthesis 0.825155064128444 -0.192183953789743 17 2 0.0127388535031847 157 902 157506,51109 RDH10,RDH11 HUMAN_PWY-6353 purine nucleotides degradation 0.853817419055049 -0.158037903068487 10 1 0.00636942675159236 157 902 3614 IMPDH1 HUMAN_DETOX1-PWY-1 reactive oxygen species degradation 0.853817419055049 -0.158037903068487 10 1 0.00636942675159236 157 902 847 CAT META_PWY-6368 3-phosphoinositide degradation 0.870500835905073 -0.138686559515798 19 2 0.0127388535031847 157 902 8897,5728 MTMR3,PTEN HUMAN_PWY-6309 L-kynurenine degradation 0.879546864358788 -0.128348430995265 11 1 0.00636942675159236 157 902 2806 GOT2 HUMAN_PWY-7176 UTP and CTP de novo biosynthesis 0.879546864358788 -0.128348430995265 11 1 0.00636942675159236 157 902 1503 CTPS1 HUMAN_NADSYN-PWY NAD de novo biosynthesis 0.879546864358788 -0.128348430995265 11 1 0.00636942675159236 157 902 55191 NADSYN1 HUMAN_PWY-6368 3-phosphoinositide degradation 0.888896276902778 -0.117774724175299 20 2 0.0127388535031847 157 902 8897,5728 MTMR3,PTEN HUMAN_LIPASYN-PWY phospholipases 0.905525770991522 -0.0992395415539739 29 3 0.0191082802547771 157 902 23646,50640,51259 PLD3,PNPLA8,TMEM216 HUMAN_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.918275845928751 -0.0852574477372842 13 1 0.00636942675159236 157 902 1503 CTPS1 META_PWY-5328 superpathway of L-methionine salvage and degradation 0.918275845928751 -0.0852574477372842 13 1 0.00636942675159236 157 902 4548 MTR HUMAN_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.944605816531799 -0.0569875638725541 15 1 0.00636942675159236 157 902 3632 INPP5A META_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.944605816531799 -0.0569875638725541 15 1 0.00636942675159236 157 902 3632 INPP5A META_PWY-6558 heparan sulfate biosynthesis (late stages) 0.962489123546235 -0.0382325130957496 17 1 0.00636942675159236 157 902 2132 EXT2 HUMAN_PWY-4061 glutathione-mediated detoxification 0.974623748727233 -0.0257037812036694 19 1 0.00636942675159236 157 902 373156 GSTK1 META_PWY-6564 heparan sulfate biosynthesis 0.988420465878921 -0.0116470990127244 23 1 0.00636942675159236 157 902 2132 EXT2 HUMAN_PWY66-401 superpathway of tryptophan utilization 0.998046873625063 -0.00195503621343148 32 1 0.00636942675159236 157 902 55191 NADSYN1 HUMAN_PWY0-1313 acetate conversion to acetyl-CoA 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PROPIONMET-PWY propionyl-CoA degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6076 vitamin D3 biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6620 guanine and guanosine salvage 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_CHOLINE-BETAINE-ANA-PWY choline degradation I 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6129 dolichol and dolichyl phosphate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6076 vitamin D3 biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6117 spermine and spermidine degradation I 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-7179-1 purine deoxyribonucleosides degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_GLYSYN-ALA-PWY glycine biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PROPIONMET-PWY propanoyl CoA degradation I 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY66-394 aspirin triggered resolvin E biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY66-397 resolvin D biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-5340 sulfate activation for sulfonation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-388 fatty acid alpha-oxidation III 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6118 glycerol-3-phosphate shuttle 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY6666-2 dopamine degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY0-1295 pyrimidine ribonucleosides degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6688 thyronamine and iodothyronamine metabolism 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-301 catecholamine biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_BETA-ALA-DEGRADATION-I-PWY beta-alanine degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6566 chondroitin biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-5874 heme degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY6666-1 anandamide degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY3O-4106 NAD salvage pathway III 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6620 guanine and guanosine salvage 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6118 glycerol-3-phosphate shuttle 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6370 ascorbate recycling (cytosolic) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-5686 UMP biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-397 resolvin D biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6241 thyroid hormone biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-5525 D-glucuronate degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-14 MAP kinase cascade 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-5340 sulfate activation for sulfonation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-0 putrescine degradation III 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_ASPARTATESYN-PWY aspartate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY0-1182 trehalose degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY0-1275 lipoate biosynthesis and incorporation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_GLUTAMINDEG-PWY glutamine degradation/glutamate biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-5030 L-histidine degradation III 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6688 thyronamine and iodothyronamine metabolism 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY66-395 aspirin triggered resolvin D biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_FASYN-ELONG-PWY fatty acid elongation -- saturated 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-4041 gamma-glutamyl cycle 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_LYSINE-DEG1-PWY L-lysine degradation XI (mammalian) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-394 aspirin triggered resolvin E biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY66-395 aspirin triggered resolvin D biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6012-1 acyl carrier protein metabolism 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6482 diphthamide biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_CYSTEINE-DEG-PWY L-cysteine degradation I 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6181 histamine degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_LYSINE-DEG1-PWY lysine degradation I (saccharopine pathway) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_SERDEG-PWY L-serine degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_GLUDEG-I-PWY GABA shunt 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-7179-1 purine deoxyribonucleosides degradation II 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-5505 L-glutamate and L-glutamine biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PROUT-PWY L-proline degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_GLYSYN-PWY glycine/serine biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-1801 formaldehyde oxidation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_PWY-5137 fatty acid beta-oxidation (unsaturated, odd number) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 HUMAN_CHOLINE-BETAINE-ANA-PWY choline degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6370 ascorbate recycling (cytosolic) 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY-6181 histamine degradation 0.99999999999625 -3.75022929377522e-12 2 0 0 157 902 META_PWY66-382 mineralocorticoid biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-5996 oleate biosynthesis II (animals and fungi) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY6666-2 dopamine degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-6609 adenine and adenosine salvage III 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY66-381 glucocorticoid biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_2PHENDEG-PWY phenylethylamine degradation I 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY0-1295 pyrimidine ribonucleosides degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_ASPARAGINE-DEG1-PWY-1 L-asparagine degradation III (mammalian) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-6000 gamma-linolenate biosynthesis II (animals) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6158 creatine-phosphate biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-4202 arsenate detoxification I (glutaredoxin) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_GLYCLEAV-PWY glycine cleavage 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-392 lipoxin biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY66-382 mineralocorticoid biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6430 thymine degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_OXIDATIVEPENT-PWY-1 pentose phosphate pathway (oxidative branch) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-381 glucocorticoid biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-21 ethanol degradation II 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-301 catecholamine biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-7511 protein ubiquitylation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-6875 retinoate biosynthesis II 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY0-1296 purine ribonucleosides degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-3982 uracil degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_NAD-BIOSYNTHESIS-III NAD salvage 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-6318 L-phenylalanine degradation IV (mammalian, via side chain) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-425 L-lysine degradation II (L-pipecolate pathway) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6609 adenine and adenosine salvage III 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-161 oxidative ethanol degradation III 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-5661 GDP-glucose biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-4202 arsenate detoxification I (glutaredoxin) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-3982 uracil degradation I (reductive) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY66-387 fatty acid alpha-oxidation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_GLYCLEAV-PWY glycine cleavage 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_GLUDEG-I-PWY GABA shunt 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-5661-1 GDP-glucose biosynthesis II 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PHENYLALANINE-DEG1-PWY phenylalanine degradation/tyrosine biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_GLYCINE-SYN2-PWY glycine biosynthesis II 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY0-1264 biotin-carboxyl carrier protein assembly 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-221 nicotine degradation V 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6307 tryptophan degradation via tryptamine 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY66-392 lipoxin biosynthesis 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-387 fatty acid alpha-oxidation II 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY66-422 D-galactose degradation V (Leloir pathway) 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 HUMAN_PWY-6608 guanosine nucleotides degradation 0.99999999999967 -3.29763993889287e-13 3 0 0 157 902 META_PWY-6756 S-methyl-5'-thioadenosine degradation II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6133 (S)-reticuline biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY66-421 homocarnosine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5329 L-cysteine degradation III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_P121-PWY adenine and adenosine salvage I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_ASPARTATESYN-PWY L-aspartate biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6273 phosphatidylethanolamine biosynthesis III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5686 UMP biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_ALANINE-SYN2-PWY L-alanine biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5148 acyl-CoA hydrolysis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6399 melatonin degradation II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_GLYCGREAT-PWY creatine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5905 hypusine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-7506 phosphatidylserine biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5966 fatty acid biosynthesis initiation II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6898 thiamin salvage III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6132 lanosterol biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY0-522 lipoate salvage 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6377 alpha-tocopherol degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_GLYCGREAT-PWY creatine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5326 sulfite oxidation IV 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_GLUT-REDOX-PWY glutathione-glutaredoxin redox reactions 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5754 4-hydroxybenzoate biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_BGALACT-PWY lactose degradation III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-40 putrescine biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7506 phosphatidylserine biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6012-1 acyl carrier protein activation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PROUT-PWY proline degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6502 oxidized GTP and dGTP detoxification 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_ARGSPECAT-PWY spermine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7219 adenosine ribonucleotides de novo biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_HOMOCYSDEGR-PWY cysteine biosynthesis/homocysteine degradation (trans-sulfuration) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5754 4-hydroxybenzoate biosynthesis I (eukaryotes) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5326 sulfite oxidation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY0-1305 glutamate dependent acid resistance 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_GLNSYN-PWY L-glutamine biosynthesis I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-4101 sorbitol degradation I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_SERDEG-PWY L-serine degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7112 4-hydroxy-2-nonenal detoxification 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-1722 formate assimilation into 5,10-methylenetetrahydrofolate 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-40 putrescine biosynthesis I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6619 adenine and adenosine salvage VI 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY66-421 homocarnosine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5766 L-glutamate degradation X 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6173 histamine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6756 S-methyl-5'-thioadenosine degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY66-241 bupropion degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_GLUTAMATE-SYN2-PWY glutamate biosynthesis/degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY66-420 carnosine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7344 UDP-D-galactose biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_GLUTAMATE-SYN2-PWY L-glutamate biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_HISHP-PWY L-histidine degradation VI 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_ARGSPECAT-PWY spermine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_ALANINE-DEG3-PWY L-alanine degradation III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and dephosphorylation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6132 lanosterol biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY66-426 hydrogen sulfide biosynthesis (trans-sulfuration) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY6666-1 anandamide degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY66-420 carnosine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_MANNCAT-PWY D-mannose degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6535 4-aminobutyrate degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY66-380 estradiol biosynthesis I (via estrone) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6173 histamine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6481 L-dopachrome biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5329 L-cysteine degradation II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_GLUT-REDOX-PWY glutathione redox reactions II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_MGLDLCTANA-PWY methylglyoxal degradation VI 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-5963 thio-molybdenum cofactor biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6502 oxidized GTP and dGTP detoxification 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-5886 4-hydroxyphenylpyruvate biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY0-1313 acetate conversion to acetyl-CoA 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6377 alpha-tocopherol degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY0-1021 L-alanine biosynthesis III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_ALANINE-DEG3-PWY alanine biosynthesis/degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6134 L-tyrosine biosynthesis IV 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_GLNSYN-PWY glutamine biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6307 L-tryptophan degradation X (mammalian, via tryptamine) 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY66-388 fatty acid alpha-oxidation III 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6481 L-dopachrome biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-7435 mucin core 3 and core 4 O-glycosylation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6241 thyroid hormone biosynthesis 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6535 4-aminobutanoate degradation I 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_MGLDLCTANA-PWY methylglyoxal degradation VI 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-7306 estradiol biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6619 adenine and adenosine salvage II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-6334 L-dopa degradation 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 HUMAN_PWY-2161B glutamate removal from folates 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6133 (S)-reticuline biosynthesis II 1.00000000000061 6.07736083679811e-13 1 0 0 157 902 META_PWY-6823 molybdenum cofactor biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY66-380 estradiol biosynthesis I 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6030 serotonin and melatonin biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-7434 terminal O-glycans residues modification 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-7205 CMP phosphorylation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-2161 folate polyglutamylation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-6875 retinoate biosynthesis II 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-6568 dermatan sulfate biosynthesis (late stages) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY66-373 sucrose degradation V (sucrose alpha-glucosidase) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-6030 serotonin and melatonin biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-5659 GDP-mannose biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6158 creatine-phosphate biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_ASPARAGINE-DEG1-PWY-1 asparagine degradation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6313 serotonin degradation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-7181 pyrimidine deoxyribonucleosides degradation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-4921 protein citrullination 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6608 guanosine nucleotides degradation III 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY66-21 ethanol degradation II 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-5874 heme degradation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6061 bile acid biosynthesis, neutral pathway 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-4984 urea cycle 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-6568 dermatan sulfate biosynthesis (late stages) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-7112 4-hydroxy-2-nonenal detoxification 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-6823 molybdenum cofactor biosynthesis 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY66-425 lysine degradation II (pipecolate pathway) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-5994 palmitate biosynthesis I (animals and fungi) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-4261 glycerol degradation 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 HUMAN_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 1.0000000000021 2.10076682612137e-12 4 0 0 157 902 META_PWY-5189 tetrapyrrole biosynthesis II (from glycine) 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-4983 citrulline-nitric oxide cycle 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-7181 pyrimidine deoxyribonucleosides degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-3661-1 glycine betaine degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-6566 chondroitin biosynthesis 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-3661-1 glycine betaine degradation II (mammalian) 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_TYRFUMCAT-PWY L-tyrosine degradation I 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_SALVADEHYPOX-PWY adenosine nucleotides degradation II 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-6342 noradrenaline and adrenaline degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_TYRFUMCAT-PWY tyrosine degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY66-378 androgen biosynthesis 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-6398 melatonin degradation I 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-4983 L-citrulline-nitric oxide cycle 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_VALDEG-PWY L-valine degradation I 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-6402 superpathway of melatonin degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY66-161 oxidative ethanol degradation III 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY66-378 androgen biosynthesis 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY66-201 nicotine degradation IV 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-4061 glutathione-mediated detoxification I 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY66-241 bupropion degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-5189 tetrapyrrole biosynthesis 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-5030 histidine degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-4921 protein citrullination 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-4984 urea cycle 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-7209 superpathway of pyrimidine ribonucleosides degradation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 HUMAN_PWY-5966-1 fatty acid biosynthesis initiation 1.00000000000386 3.85797402596526e-12 5 0 0 157 902 META_PWY66-428 L-threonine degradation V 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 META_PWY-5972 stearate biosynthesis I (animals and fungi) 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-5996 oleate biosynthesis 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 META_PWY-5130 2-oxobutanoate degradation I 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-7455 allopregnanolone biosynthesis 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 META_PWY-7455 allopregnanolone biosynthesis 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY66-373 sucrose degradation 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-7209 pyrimidine ribonucleosides degradation 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-6313 serotonin degradation 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY66-428 threonine degradation 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 HUMAN_PWY-5130 2-oxobutanoate degradation 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 META_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 1.00000000000462 4.61974411158851e-12 6 0 0 157 902 META_PWY-6872 retinoate biosynthesis I 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 HUMAN_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 HUMAN_PWY66-221 nicotine degradation III 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 HUMAN_PWY-5994 palmitate biosynthesis 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 META_PWY-6567 chondroitin sulfate biosynthesis (late stages) 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 HUMAN_PWY66-414 superpathway of choline degradation to L-serine 1.00000000000635 6.35221420209882e-12 7 0 0 157 902 HUMAN_PWY-6567 chondroitin sulfate biosynthesis (late stages) 1.00000000000775 7.7506199723742e-12 8 0 0 157 902 HUMAN_TRYPTOPHAN-DEGRADATION-1 tryptophan degradation 1.00000000000775 7.7506199723742e-12 8 0 0 157 902 HUMAN_SALVADEHYPOX-PWY adenosine nucleotides degradation 1.00000000000775 7.7506199723742e-12 8 0 0 157 902 HUMAN_PWY-6872 retinoate biosynthesis I 1.00000000000775 7.7506199723742e-12 8 0 0 157 902 META_PWY-7305 superpathway of steroid hormone biosynthesis 1.00000000000969 9.69119704082977e-12 9 0 0 157 902 HUMAN_PWY-6342 noradrenaline and adrenaline degradation 1.00000000000969 9.69119704082977e-12 9 0 0 157 902 HUMAN_PWY-7205 CMP phosphorylation 1.00000000000969 9.69119704082977e-12 9 0 0 157 902 HUMAN_PWY-6398 melatonin degradation I 1.00000000001189 1.18924835289125e-11 10 0 0 157 902 HUMAN_PWY66-201 nicotine degradation IV 1.00000000001189 1.18924835289125e-11 10 0 0 157 902 HUMAN_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 1.00000000001189 1.18924835289125e-11 10 0 0 157 902 HUMAN_PWY-6402 superpathway of melatonin degradation 1.00000000001246 1.24553063176547e-11 11 0 0 157 902 HUMAN_LIPAS-PWY triacylglycerol degradation 1.00000000001246 1.24553063176547e-11 11 0 0 157 902 HUMAN_PWY-6571 dermatan sulfate biosynthesis 1.00000000001509 1.50913797210971e-11 12 0 0 157 902 HUMAN_PWY-7305 superpathway of steroid hormone biosynthesis 1.00000000001509 1.50913797210971e-11 12 0 0 157 902 HUMAN_PWY-6061 bile acid biosynthesis, neutral pathway 1.00000000001509 1.50913797210971e-11 12 0 0 157 902 META_PWY-6571 dermatan sulfate biosynthesis 1.00000000002016 2.01580058806093e-11 15 0 0 157 902 HUMAN_PWY-6569 chondroitin sulfate biosynthesis 1.00000000002117 2.11698917799051e-11 16 0 0 157 902 META_PWY-6569 chondroitin sulfate biosynthesis 1.00000000002322 2.32175351720213e-11 18 0 0 157 902 HUMAN_PWY-6558 heparan sulfate biosynthesis (late stages) 1.0000000000251 2.51029639982923e-11 19 0 0 157 902 HUMAN_PWY-6564 heparan sulfate biosynthesis 1.0000000000316 3.1598920674246e-11 25 0 0 157 902