TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
R-HSA-74160	Gene Expression	1.797935411506e-27	-61.5831584978455	1821	463	0.272995283018868	1696	10287	84838,3015,7295,23511,7249,10713,891,7329,51728,6147,1020,27042,5707,10073,25926,6429,7752,6434,9972,30834,1786,5094,81929,64223,10772,988,1263,6731,84527,208,54888,79813,6924,3185,11218,9212,5982,1207,8661,55677,4087,6233,5714,115509,6208,25824,10785,9377,56006,7029,7627,8086,10285,3066,6749,11325,124411,1329,84626,5440,23480,5562,23708,1660,4697,54205,4853,10081,7633,5715,5073,56339,79577,133746,4849,6184,8894,23016,25896,9343,51493,4436,50628,10898,55178,26986,79902,387338,5464,1936,79587,9295,51386,22936,9219,54881,51639,55253,6204,79837,4605,6746,6229,5393,6430,7458,219988,8175,5691,221830,355,2058,27153,5439,5859,27316,51586,129450,57472,2821,7528,1017,9818,29959,1029,3735,55706,112858,1788,84324,23451,23512,8664,22974,116028,10308,79074,7626,147923,890,7586,51096,9112,57122,64859,57117,1027,7769,9716,7159,1386,58490,51755,29960,8819,10952,5983,5441,55726,6169,51340,10921,5433,7884,5698,54433,94239,10155,11198,6873,5515,27335,8427,29927,1650,54487,11157,10607,28996,115024,27068,6176,24140,3014,2521,6637,22984,1453,136051,9612,6187,353274,6431,51605,641,88745,56902,168374,2962,84991,6118,8812,5708,22826,5728,6139,55835,55802,79833,6143,26019,246175,374655,10370,2966,200916,10499,4670,5170,2648,57418,6132,9790,6157,10212,5052,5430,6117,11335,27340,7733,6161,7027,5371,10128,8570,1655,7533,6878,705,11056,6096,892,51202,9984,4839,9939,1457,6634,1432,6621,55215,79943,80153,6745,10914,11103,10992,200424,5111,23225,9775,26173,57721,55687,10248,26155,6917,1983,4603,55749,10498,54913,4234,84248,51520,23020,118460,11176,3035,6628,672,55840,57050,8575,1665,6009,25929,6167,54623,7343,1107,1874,23350,55699,10084,9031,27297,6794,9128,10795,60,11200,7596,5700,6231,79760,163050,7323,348180,6209,8649,6138,1327,8621,55571,7270,51593,23165,79622,57103,112950,84246,8932,155061,8896,9646,4904,79664,9794,7743,5438,6128,84135,5682,23168,388561,5704,25873,6257,7248,9167,389541,23636,7534,146198,6625,5928,116461,7874,9092,5564,6181,10523,56949,5395,8270,55659,64121,5093,10605,64769,6135,3181,79595,23478,2193,54700,4193,5687,25888,3376,27154,55900,10849,5300,51013,6185,26097,54989,84916,79685,147949,1477,27339,6159,29107,11224,5436,143471,26048,7832,10450,5695,51691,9631,9129,10907,53615,6203,8666,3921,8667,6426,57794,57693,90592,10236,5933,8449,5709,80818,8648,2197,3020,4089,5892,54883,57508,9150,51362,7978,839,8480,27161,53371,2971,80010,5305,84705,56259,10283,387893,79035,54920,8125,29117,84172,2091,112495,55197,7753,7156,117584,84265,23398,4221,8189,6626,6897,5595,9416,9125,5976,29028,332,1869,1351,124446,3516,6883,60559,6428	ZNF496,H2AFZ,TXN,NUP188,TSC2,USP39,CCNB1,UBE2I,POLR3K,RPL23A,CDK5,UTP25,PSMD1,SNUPN,NOL11,SRSF4,ZNF200,TRA2B,NUP153,ZNRD1,DNMT1,PCBP2,SEH1L,MLST8,SRSF10,CDC5L,PLK3,SRP72,ZNF559,AKT2,NSUN2,EHMT1,ELOA,HNRNPF,DDX20,AURKB,RFC2,CLNS1A,EIF3A,IWS1,SMAD2,RPS27A,PSMD8,ZNF689,RPS14,PRDX5,WDR4,COX5A,SMG9,TFDP2,ZNF75A,AAAS,SMNDC1,HDAC2,SSRP1,DDX42,ZNF720,COX5B,KRBA1,POLR2K,SEC61G,PRKAA1,GSPT2,DHX9,NDUFA4,CYCS,NOTCH2,PDCD7,ZNF79,PSMD9,PARN,METTL3,CDC73,JMY,CNOT3,RPN1,EIF2S2,EXOSC7,INTS7,EFTUD2,RTCB,MSH2,GEMIN4,CPSF4,MRM3,PABPC1,NUP85,NSUN4,PPA1,EEF1D,CARS2,SRSF11,EIF3L,ELL2,MTA2,TEX10,SF3B6,TYW1,RPS10,PIP4K2C,MYBL2,SSR2,RPS24,EXOSC9,SRSF5,EIF4H,PATL1,SF3A2,PSMB3,TWISTNB,FAS,EPRS,ZNF777,POLR2J,QARS,RBMX,MED15,TYW5,CNOT6,GPI,YY1,CDK2,NUP58,NRBP1,CDKN2A,KARS,NDC1,TP53RK,DNMT3A,SARNP,SF3B1,SUZ12,EIF3D,TPX2,RMI2,ZNF267,C2orf49,ZNF75D,ZNF420,CCNA2,ZKSCAN1,UTP18,MTA1,NUP107,NABP1,INTS12,CDKN1B,ZNF226,AQR,TP53BP2,ATF2,RPRD1B,CDK12,MRM2,SAP30,SEC61B,RFC3,POLR2L,INTS13,RPL38,CRNKL1,RNPS1,POLR2D,SLBP,PSMB9,GAR1,H2AFV,TRIM28,SUPT16H,TAF2,PPP2CA,EIF3K,ZNF282,SEC61A1,DDOST,DGCR8,LSM6,TBL3,HIPK2,NT5C3B,PPA2,RPLP1,FTSJ1,H2AFX,FUS,SNRPG,PDCD11,CSNK1D,ZNF786,NCOR2,RPS2,ZNF445,SRSF6,TRMT6,BLM,RRP36,PNO1,ZNF92,GTF2F1,RBM17,RPA2,CCNK,PSMD2,DNAJC8,PTEN,RPL17,CENPJ,DCP1A,GEMIN6,RPL19,UPF2,CNOT6L,ZNF710,CITED2,GTF2H2,RPL22L1,NCOA2,HNRNPM,PDPK1,KAT2A,WDR18,RPL8,BMS1,RPL27A,DDX39A,PRDX1,POLR2A,RPA1,CBX3,UTP20,ZNF180,RPL32,TFDP1,PML,LRPPRC,KHSRP,DDX5,YWHAH,TAF6,BYSL,DDX52,RORB,CCNC,DDX47,THOC1,NOP2,RBM8A,CSNK2A1,SNRPD3,MAPK14,SNAPC4,FANCI,ZNF696,EDC3,SSR1,PAPOLA,KRR1,SF3B2,TET3,PCNA,NUP210,EIF4A3,INTS1,METTL14,TRMU,POP7,NOC2L,TCEA1,EIF5,MYBL1,CCAR1,CARM1,RPP25,METTL1,FYTTD1,LARS,SNRNP200,EXOSC6,BAZ2A,HARS,SNRPB,BRCA1,EAF2,UTP3,PRKRA,DHX15,RHEB,GEMIN5,RPL37,PAF1,UBTF,CHD3,E2F4,U2SURP,IARS2,PQBP1,BAZ1B,CRCP,STK11,PRPF4,ZNF268,ACTB,CHEK2,ZNF45,PSMC1,RPS26,GEMIN7,ZNF564,UBE2D3,CTU2,RPS15,LAMTOR3,RPL15,COX4I1,CDK13,CNOT11,TTF1,SRRT,NUP205,SNRNP25,TIGAR,MED8,MED10,MBD2,ZNF746,BUD31,CTR9,YBX1,ICE2,MAML1,ZNF189,POLR2I,RPL6,UTP15,PSMA1,RTF1,ZNF761,PSMC4,RPL36,RXRB,TSC1,COX7A2L,LAMTOR4,NUP62,YWHAZ,ZFP90,SNRNP70,RBBP4,TSEN15,USP7,SART1,PRKAB1,RPLP2,CHERP,XAB2,PMS2,LAGE3,ZNF416,RRAGC,PCBP1,PAIP1,MEAF6,RPL11,HNRNPA2B1,SAP130,SEC11A,FARSA,RRN3,MDM2,PSMA6,ZNF473,IARS,BRPF3,ZNF302,CD3EAP,PIN1,EXOSC1,RPN2,CHTOP,ZNF770,UTP4,SAP30L,ZNF583,CSTF1,PRPF19,RPL29,NXT1,RPL35,POLR2G,PSMA8,ZNF500,BTG2,PPIE,PSMB7,LSM8,NUP155,PRPF3,TXNL4A,MBD3,RPS9,EIF3G,RPSA,EIF3H,SRSF1,SUGP1,ZNF317,ZNF700,HNRNPR,RBL1,DHX16,PSMD3,ZNF436,NCOA1,FAU,H3F3A,SMAD4,RAD51D,CWC25,INTS2,CTDP1,CDC40,MTERF1,CASP6,RAE1,AGO2,NUP54,GTF3A,RMI1,PIP4K2A,GTPBP3,CTNNBL1,CWC27,KMT5A,NABP2,DUS2,ANP32A,BRD7,POLR1B,FBL,GTF3C6,RPRD1A,ZNF202,TOP3A,RFFL,POLR3GL,PPWD1,MEN1,SYMPK,SNRPA,TARS,MAPK3,DDX23,CNOT9,UPF1,ATAD2,BIRC5,E2F1,COX8A,TMEM219,RBPJ,TAF12,SPCS3,SRSF3
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	6.08250570947183e-21	-46.548870218528	247	102	0.0601415094339623	1696	10287	9092,55706,84324,23511,9984,10523,56949,23451,9939,10713,6634,5093,10914,10992,3181,23225,9775,57721,6429,57122,6434,9972,9716,26097,55749,5094,81929,10772,1477,27339,988,84248,23020,29107,5436,5441,6628,10450,51340,10921,3185,5433,7884,51691,9631,9129,10907,1665,6426,57794,10236,11157,8449,23350,10084,9128,2521,6637,8086,10285,11325,54883,51362,5440,6431,8480,53371,1660,10081,56339,51593,23165,2962,84991,79622,22826,56259,10283,9343,8896,4904,10898,79902,4670,9295,5438,51639,6430,23398,10212,8189,8175,6626,5430,9416,5439,27316,23636,1655,6428,6625,9818	SART1,NDC1,SARNP,NUP188,THOC1,CHERP,XAB2,SF3B1,RBM8A,USP39,SNRPD3,PCBP1,PAPOLA,SF3B2,HNRNPA2B1,NUP210,EIF4A3,METTL14,SRSF4,NUP107,TRA2B,NUP153,AQR,CHTOP,CCAR1,PCBP2,SEH1L,SRSF10,CSTF1,PRPF19,CDC5L,FYTTD1,SNRNP200,NXT1,POLR2G,POLR2L,SNRPB,PPIE,CRNKL1,RNPS1,HNRNPF,POLR2D,SLBP,LSM8,NUP155,PRPF3,TXNL4A,DHX15,SRSF1,SUGP1,HNRNPR,LSM6,DHX16,U2SURP,PQBP1,PRPF4,FUS,SNRPG,AAAS,SMNDC1,DDX42,CWC25,CDC40,POLR2K,SRSF6,RAE1,NUP54,DHX9,PDCD7,METTL3,SRRT,NUP205,GTF2F1,RBM17,SNRNP25,DNAJC8,CTNNBL1,CWC27,EFTUD2,BUD31,YBX1,CPSF4,NUP85,HNRNPM,SRSF11,POLR2I,SF3B6,SRSF5,PPWD1,DDX39A,SYMPK,SF3A2,SNRPA,POLR2A,DDX23,POLR2J,RBMX,NUP62,DDX5,SRSF3,SNRNP70,NUP58
R-HSA-69278	Cell Cycle, Mitotic	9.31064541332654e-20	-43.8205434462551	514	166	0.097877358490566	1696	10287	23649,11116,4149,3015,23511,2029,8454,1457,11004,891,79003,286826,1031,4218,5111,5707,23225,10783,23047,9972,994,81929,5347,8615,9978,208,6241,990,9212,10592,4171,5982,84296,10133,5557,6233,5714,1874,7029,1870,5700,8086,22919,4659,64689,1063,9493,54930,11243,5715,55142,23165,4000,5925,9126,9738,4174,8815,23194,9735,79648,79902,5558,4605,5682,26003,5691,5704,93323,84930,5108,2801,996,4957,113130,23636,5928,54820,1017,9133,9818,1029,55706,2305,8655,9232,22974,83540,4998,5566,5687,25909,890,9663,57122,1027,51434,80254,1639,23141,5983,143471,57551,114791,5695,1871,9631,9088,8697,5861,94239,5698,79682,5515,3796,8881,5525,79980,5933,5709,3014,3020,5594,55844,203068,1453,55388,8480,81620,10540,10926,53371,55143,54908,984,64151,10844,26271,6118,5708,55835,387893,51512,79019,23595,10051,10726,9837,140609,29882,5905,79866,728642,5595,6117,221496,81930,5426,332,7027,1869,8636,80152,11065,9700,29945	POLA2,FGFR1OP,MAX,H2AFZ,NUP188,ENSA,CUL1,CSNK2A1,KIF2C,CCNB1,MIS12,LIN9,CDKN2C,RAB8A,PCNA,PSMD1,NUP210,NEK6,PDS5B,NUP153,CDC25B,SEH1L,PLK1,USO1,RBX1,AKT2,RRM2,CDC6,AURKB,SMC2,MCM2,RFC2,GINS4,OPTN,PRIM1,RPS27A,PSMD8,E2F4,TFDP2,E2F2,PSMC1,AAAS,MAPRE1,PPP1R12A,GORASP1,CENPF,KIF23,HAUS4,PMF1,PSMD9,HAUS2,NUP205,LMNA,RB1,SMC3,CCP110,MCM5,BANF1,FBXL7,KNTC1,MCPH1,NUP85,PRIM2,MYBL2,PSMA1,GORASP2,PSMB3,PSMC4,HAUS8,MASTL,PCM1,GOLGA2,CDC27,ODF2,CDCA5,NUP62,RBBP4,NDE1,CDK2,CCNB2,NUP58,CDKN2A,NDC1,FOXM1,DYNLL1,PTTG1,TPX2,NUF2,ORC1,PRKACA,PSMA6,AHCTF1,CCNA2,LPIN2,NUP107,CDKN1B,ANAPC7,CEP63,DCTN1,ANKLE2,RFC3,PSMA8,TAOK1,TUBGCP5,PSMB7,E2F3,NUP155,PKMYT1,CDC23,RAB1A,H2AFV,PSMB9,CENPU,PPP2CA,KIF2A,CDC16,PPP2R5A,DSN1,RBL1,PSMD3,H2AFX,H3F3A,MAPK1,PPP2R2D,TUBB,CSNK1D,MCM10,RAE1,CDT1,DCTN2,DBF4,NUP54,CDCA8,SPDL1,CDK11B,NCAPG,TUBGCP2,FBXO5,RPA2,PSMD2,CENPJ,KMT5A,GTSE1,CENPM,ORC3,SMC4,NUDC,GINS1,NEK7,ANAPC2,RANGAP1,BORA,CDK11A,MAPK3,RPA1,LEMD2,KIF18A,POLE,BIRC5,TFDP1,E2F1,SSNA1,CENPT,UBE2C,ESPL1,ANAPC4
R-HSA-1640170	Cell Cycle	3.33828811289146e-19	-42.5436586323428	621	189	0.111438679245283	1696	10287	23649,11116,4149,3015,23511,2029,8454,1457,11004,891,7329,79003,286826,1031,4218,5111,5707,23225,10783,23047,9972,994,81929,5347,8615,9978,208,6241,990,9212,672,10592,11083,4171,5982,84296,10133,5557,6233,5714,1874,11200,7029,1870,5700,25913,8086,22919,4659,55355,63967,64689,1063,9493,54930,11243,5715,55142,23165,4000,5925,9126,9738,4174,8815,23194,9735,79648,79902,7014,5558,4605,5682,26003,5691,5704,93323,84930,5108,2801,996,4957,113130,23636,7534,10856,5928,54820,1017,9133,9818,1029,55706,2305,8655,9232,116028,22974,83540,4998,5566,54386,11339,4193,25909,5687,890,9577,9663,57122,1027,51434,80254,1639,23141,84057,5983,143471,57551,114791,5695,1871,9631,9088,8697,5861,94239,5698,79682,5515,3796,5889,8881,5525,79980,5933,5709,3014,3020,5594,55844,203068,1453,55388,8480,81620,10540,29086,10926,53371,55143,54908,984,641,64151,80010,10844,26271,6118,5708,55835,387893,51512,79019,23595,10051,10726,9837,140609,7156,29882,5905,79866,728642,5595,6117,221496,81930,5426,332,7027,1869,8636,80152,11065,7533,7013,9700,29945	POLA2,FGFR1OP,MAX,H2AFZ,NUP188,ENSA,CUL1,CSNK2A1,KIF2C,CCNB1,UBE2I,MIS12,LIN9,CDKN2C,RAB8A,PCNA,PSMD1,NUP210,NEK6,PDS5B,NUP153,CDC25B,SEH1L,PLK1,USO1,RBX1,AKT2,RRM2,CDC6,AURKB,BRCA1,SMC2,DIDO1,MCM2,RFC2,GINS4,OPTN,PRIM1,RPS27A,PSMD8,E2F4,CHEK2,TFDP2,E2F2,PSMC1,POT1,AAAS,MAPRE1,PPP1R12A,HJURP,CLSPN,GORASP1,CENPF,KIF23,HAUS4,PMF1,PSMD9,HAUS2,NUP205,LMNA,RB1,SMC3,CCP110,MCM5,BANF1,FBXL7,KNTC1,MCPH1,NUP85,TERF2,PRIM2,MYBL2,PSMA1,GORASP2,PSMB3,PSMC4,HAUS8,MASTL,PCM1,GOLGA2,CDC27,ODF2,CDCA5,NUP62,YWHAZ,RUVBL2,RBBP4,NDE1,CDK2,CCNB2,NUP58,CDKN2A,NDC1,FOXM1,DYNLL1,PTTG1,RMI2,TPX2,NUF2,ORC1,PRKACA,TERF2IP,OIP5,MDM2,AHCTF1,PSMA6,CCNA2,BABAM2,LPIN2,NUP107,CDKN1B,ANAPC7,CEP63,DCTN1,ANKLE2,MND1,RFC3,PSMA8,TAOK1,TUBGCP5,PSMB7,E2F3,NUP155,PKMYT1,CDC23,RAB1A,H2AFV,PSMB9,CENPU,PPP2CA,KIF2A,RAD51C,CDC16,PPP2R5A,DSN1,RBL1,PSMD3,H2AFX,H3F3A,MAPK1,PPP2R2D,TUBB,CSNK1D,MCM10,RAE1,CDT1,DCTN2,BABAM1,DBF4,NUP54,CDCA8,SPDL1,CDK11B,BLM,NCAPG,RMI1,TUBGCP2,FBXO5,RPA2,PSMD2,CENPJ,KMT5A,GTSE1,CENPM,ORC3,SMC4,NUDC,GINS1,NEK7,TOP3A,ANAPC2,RANGAP1,BORA,CDK11A,MAPK3,RPA1,LEMD2,KIF18A,POLE,BIRC5,TFDP1,E2F1,SSNA1,CENPT,UBE2C,YWHAH,TERF1,ESPL1,ANAPC4
R-HSA-72163	mRNA Splicing - Major Pathway	5.18497847596401e-16	-35.1955957974442	187	77	0.0454009433962264	1696	10287	9092,10523,56949,23451,9939,10713,6634,5093,10914,10992,3181,9775,6429,6434,9716,55749,5094,10772,1477,27339,988,23020,5436,5441,6628,10450,51340,3185,5433,10921,51691,9129,10907,1665,6426,57794,10236,11157,8449,23350,10084,9128,2521,6637,10285,11325,54883,51362,5440,6431,1660,51593,2962,84991,22826,56259,10283,9343,8896,4904,10898,4670,9295,5438,51639,23398,6430,8189,8175,6626,5430,9416,5439,27316,1655,6428,6625	SART1,CHERP,XAB2,SF3B1,RBM8A,USP39,SNRPD3,PCBP1,PAPOLA,SF3B2,HNRNPA2B1,EIF4A3,SRSF4,TRA2B,AQR,CCAR1,PCBP2,SRSF10,CSTF1,PRPF19,CDC5L,SNRNP200,POLR2G,POLR2L,SNRPB,PPIE,CRNKL1,HNRNPF,POLR2D,RNPS1,LSM8,PRPF3,TXNL4A,DHX15,SRSF1,SUGP1,HNRNPR,LSM6,DHX16,U2SURP,PQBP1,PRPF4,FUS,SNRPG,SMNDC1,DDX42,CWC25,CDC40,POLR2K,SRSF6,DHX9,SRRT,GTF2F1,RBM17,DNAJC8,CTNNBL1,CWC27,EFTUD2,BUD31,YBX1,CPSF4,HNRNPM,SRSF11,POLR2I,SF3B6,PPWD1,SRSF5,SYMPK,SF3A2,SNRPA,POLR2A,DDX23,POLR2J,RBMX,DDX5,SRSF3,SNRNP70
R-HSA-72172	mRNA Splicing	6.48055191369663e-16	-34.9725558093007	195	79	0.0465801886792453	1696	10287	9092,10523,56949,23451,9939,10713,6634,5093,10914,10992,3181,9775,6429,6434,9716,55749,5094,10772,1477,27339,988,23020,5436,5441,6628,10450,51340,3185,5433,10921,51691,9129,10907,1665,6426,57794,10236,11157,8449,23350,10084,9128,2521,6637,10285,11325,54883,51362,5440,6431,1660,10081,51593,2962,84991,79622,22826,56259,10283,9343,8896,4904,10898,4670,9295,5438,51639,23398,6430,8189,8175,6626,5430,9416,5439,27316,1655,6428,6625	SART1,CHERP,XAB2,SF3B1,RBM8A,USP39,SNRPD3,PCBP1,PAPOLA,SF3B2,HNRNPA2B1,EIF4A3,SRSF4,TRA2B,AQR,CCAR1,PCBP2,SRSF10,CSTF1,PRPF19,CDC5L,SNRNP200,POLR2G,POLR2L,SNRPB,PPIE,CRNKL1,HNRNPF,POLR2D,RNPS1,LSM8,PRPF3,TXNL4A,DHX15,SRSF1,SUGP1,HNRNPR,LSM6,DHX16,U2SURP,PQBP1,PRPF4,FUS,SNRPG,SMNDC1,DDX42,CWC25,CDC40,POLR2K,SRSF6,DHX9,PDCD7,SRRT,GTF2F1,RBM17,SNRNP25,DNAJC8,CTNNBL1,CWC27,EFTUD2,BUD31,YBX1,CPSF4,HNRNPM,SRSF11,POLR2I,SF3B6,PPWD1,SRSF5,SYMPK,SF3A2,SNRPA,POLR2A,DDX23,POLR2J,RBMX,DDX5,SRSF3,SNRNP70
R-HSA-3700989	Transcriptional Regulation by TP53	3.84423536367909e-14	-30.8896165838383	367	118	0.0695754716981132	1696	10287	7874,5564,112858,7295,7249,5395,22974,116028,64121,1457,891,1432,55215,64769,1020,4193,5111,890,147923,27154,5300,26155,1027,6917,7159,1386,51755,10498,64223,1263,5983,5436,5441,208,7832,79813,6924,5433,9212,672,5982,53615,6009,11198,6873,5515,5933,1107,6233,1874,28996,25824,9377,6794,11200,7029,5892,3066,6749,9150,1329,839,5440,5562,27161,8649,4697,1327,8621,54205,641,55571,80010,5305,4849,133746,2962,8812,6118,57103,5728,55835,387893,4436,29117,246175,2966,5170,5438,9219,7156,79837,117584,5430,5052,6117,355,9125,7248,5439,332,9167,389541,7027,5371,10128,1869,1351,124446,57472,7534,2821,6883,5928,1017,6878,7533,1029	USP7,PRKAB1,TP53RK,TXN,TSC2,PMS2,TPX2,RMI2,RRAGC,CSNK2A1,CCNB1,MAPK14,FANCI,MEAF6,CDK5,MDM2,PCNA,CCNA2,ZNF420,BRPF3,PIN1,NOC2L,CDKN1B,TCEA1,TP53BP2,ATF2,CDK12,CARM1,MLST8,PLK3,RFC3,POLR2G,POLR2L,AKT2,BTG2,EHMT1,ELOA,POLR2D,AURKB,BRCA1,RFC2,MBD3,RHEB,SUPT16H,TAF2,PPP2CA,RBL1,CHD3,RPS27A,E2F4,HIPK2,PRDX5,COX5A,STK11,CHEK2,TFDP2,RAD51D,HDAC2,SSRP1,CTDP1,COX5B,CASP6,POLR2K,PRKAA1,AGO2,LAMTOR3,NDUFA4,COX4I1,CDK13,CYCS,BLM,CNOT11,RMI1,PIP4K2A,CNOT3,JMY,GTF2F1,CCNK,RPA2,TIGAR,PTEN,CENPJ,KMT5A,MSH2,BRD7,CNOT6L,GTF2H2,PDPK1,POLR2I,MTA2,TOP3A,PIP4K2C,RFFL,POLR2A,PRDX1,RPA1,FAS,CNOT9,TSC1,POLR2J,BIRC5,COX7A2L,LAMTOR4,TFDP1,PML,LRPPRC,E2F1,COX8A,TMEM219,CNOT6,YWHAZ,GPI,TAF12,RBBP4,CDK2,TAF6,YWHAH,CDKN2A
R-HSA-199991	Membrane Trafficking	4.1954887032598e-13	-28.4995963791832	610	169	0.0996462264150943	1696	10287	51552,51014,1314,7249,10618,3267,11004,29978,9919,81631,57589,3833,805,8774,4218,11021,5867,8907,1785,163,3835,10342,10920,80006,8615,22836,11070,208,56992,90411,8675,5869,378,10133,55707,4122,79735,146909,10972,6233,4253,27183,10980,409,9847,60592,64689,26088,51622,29924,3831,9493,29127,23423,5870,84313,26958,9276,2799,966,10092,112574,126432,23303,22920,22870,10959,10945,10113,2512,9648,9267,83696,154,10552,9527,22872,950,7248,2803,2590,2801,4905,8773,60412,7534,55291,57679,11336,5564,84079,27243,90196,9185,9322,9230,8655,11316,5879,288,10096,143187,22879,54662,162,351,85021,8027,23243,23011,57533,5537,1212,3998,60560,79571,1856,1639,7879,23299,25978,5861,23431,3796,29082,6836,1174,128866,1175,1453,1783,9371,27333,10540,11311,23647,56894,375,23062,1176,8766,7037,23396,4121,3799,156,9632,381,64708,4644,6709,6643,163486,55667,9382,117177,3832,8301,22931,9146,81930,11196,9342,221960,53407,91782,7533,5866,23557	RAB14,TMED7,COPA,TSC2,TGOLN2,AGFG1,KIF2C,UBQLN2,SEC16A,MAP1LC3B,RIC1,KIFC1,CALM2,NAPG,RAB8A,RAB35,RAB4A,AP1M1,DNM2,AP2B1,KIF22,TFG,COPS8,TRAPPC13,USO1,RHOBTB3,TMEM115,AKT2,KIF15,MCFD2,STX16,RAB5B,ARF4,OPTN,NECAP2,MAN2A2,TBC1D17,KIF18B,TMED10,RPS27A,MIA2,VPS4A,COPS6,ARRB2,C2CD5,SCOC,GORASP1,GGA1,CCZ1,EPN1,KLC1,KIF23,RACGAP1,TMED3,RAB6A,VPS25,COPG2,COPB2,GNS,CD59,ARPC5,SNX18,RINL,KIF13B,KIFAP3,PPP6R1,TMED2,KDELR1,PREB,FTL,GCC2,CYTH1,TRAPPC9,ADRB2,ARPC1A,GOSR1,SEC31A,SCARB2,TSC1,GOLGA4,GALNT2,GOLGA2,NSF,SNAP23,EXOC4,YWHAZ,PPP6R3,ALS2,EXOC3,PRKAB1,ANKRD27,CHMP2A,SYS1,REPS2,TRIP10,RAB11B,DYNLL1,COPE,RAC1,ANK3,ACTR3,VTI1A,MON1B,TBC1D13,AP1B1,APP,REPS1,STAM,ANKRD28,RAB21,TBC1D14,PPP6C,CLTB,LMAN1,NAA35,GCC1,DVL2,DCTN1,RAB7A,BICD2,CHMP2B,RAB1A,AP4E1,KIF2A,CHMP4A,SURF4,AP1S1,CHMP4B,AP2S1,CSNK1D,DYNC1LI2,KIF3B,GOLIM4,DCTN2,VPS45,ARFIP2,AGPAT3,ARF1,GGA2,AP3S1,RAB11A,TFRC,PIP5K1C,MAN1A1,KIF5B,GRK2,SEC24C,ARF5,COPS7B,MYO5A,SPTAN1,SNX2,DENND1B,DENND4C,COG1,RAB3IP,KIF11,PICALM,RAB18,HGS,KIF18A,SEC23IP,SNAP29,CCZ1B,STX18,CHMP7,YWHAH,RAB3IL1,SNAPIN
R-HSA-392499	Metabolism of proteins	1.10060004970089e-12	-27.535165585127	1619	367	0.216391509433962	1696	10287	51014,51552,3015,7295,23511,118,5589,9091,30827,54187,7329,6147,805,8774,5707,5867,5887,26190,9972,10342,29843,4249,81929,9736,6731,8615,11070,2788,9212,26503,51005,51809,23326,90411,23463,57403,8661,84932,378,4087,10972,3703,6233,5714,8312,6208,8473,6483,26224,4086,409,83752,29080,8086,8704,23586,63967,1725,26088,23480,23708,51715,2683,7155,23423,5715,5073,26958,79577,4000,57599,9276,966,6184,8894,23016,9126,1603,51564,54872,1537,56005,84282,2771,79902,26986,22870,10959,1936,1984,26521,51386,51604,221937,11253,30001,6204,6229,6746,9100,5393,154,4580,10452,9527,7458,10694,5691,22872,79139,5204,2801,4905,9063,7528,55291,11236,9818,1029,11336,55706,21,4287,9230,8664,288,283899,2783,8027,351,1912,23011,890,6464,6672,6477,51377,9112,57122,57506,1639,10576,10952,7417,6169,5861,5698,6901,27230,54927,27335,29927,1650,53917,286053,79823,6400,3014,6176,22926,8703,7518,1453,1783,8975,55593,6187,9334,29086,8604,506,641,8766,27430,5708,5728,6139,381,2530,8313,6143,8128,10651,200916,6709,7128,2648,84132,6132,23252,55288,6157,153642,6117,10897,9146,9817,6161,84061,5203,9797,5371,8570,439,51816,93183,1314,7841,65264,120526,1457,84196,8678,9919,329,7844,6745,4218,23225,5111,100287932,11021,9929,1983,92609,6670,118460,8813,25870,672,5869,27005,54623,10195,4122,6167,26517,4253,60,55568,55768,6231,5700,7323,6209,23556,54780,64689,51035,51142,6138,5870,8702,55252,7270,23165,56913,92912,116150,9738,9646,54764,9114,10945,10113,83696,7264,2629,6128,5682,23168,84447,79091,4061,25873,5704,2590,6675,60412,6478,79672,23636,5476,498,140838,7874,9804,1540,64841,6181,8655,6613,11316,6135,8078,5886,23243,23478,9577,4193,5687,23172,51013,1431,5537,6185,3998,10130,10106,6159,11224,330,143471,7879,5695,9631,221656,7416,55741,8666,2671,6203,3921,8667,3416,10440,5709,100188893,8237,2197,3020,4089,8535,55907,8480,10020,10540,55143,53371,29090,79677,285362,375,23062,4189,4121,3799,9632,6774,10559,6048,4644,7040,9761,53942,387,5591,9382,5905,4758,22931,11196,332,10868,114785,60559,11065	TMED7,RAB14,H2AFZ,TXN,NUP188,ADD1,PRKCSH,PIGQ,CXXC1,NANS,UBE2I,RPL23A,CALM2,NAPG,PSMD1,RAB4A,RAD23B,FBXW2,NUP153,TFG,SENP1,MGAT5,SEH1L,USP34,SRP72,USO1,TMEM115,GNG7,AURKB,SLC17A5,AMDHD2,GALNT7,USP22,MCFD2,ICMT,RAB22A,EIF3A,RAB2B,ARF4,SMAD2,TMED10,STT3A,RPS27A,PSMD8,AXIN1,RPS14,OGT,ST3GAL2,FBXL3,SMAD1,ARRB2,LONP2,CCDC59,AAAS,B4GALT2,DDX58,CLSPN,DHPS,GGA1,SEC61G,GSPT2,RAB23,B4GALT1,TOP2B,TMED3,PSMD9,PARN,COPG2,CDC73,LMNA,WDR48,COPB2,CD59,RPN1,EIF2S2,EXOSC7,SMC3,DAD1,HDAC7,PIGG,CYC1,MYDGF,RNF135,GNAI2,NUP85,PABPC1,PPP6R1,TMED2,EEF1D,EIF5A,TIMM8B,EIF3L,PIGT,FOXK1,MAN1B1,ERO1A,RPS10,RPS24,SSR2,USP10,EXOSC9,ADRB2,MTX1,TOMM40,GOSR1,EIF4H,CCT8,PSMB3,SEC31A,DERL1,PFDN5,GOLGA2,NSF,PIAS2,YY1,PPP6R3,RNF139,NUP58,CDKN2A,EXOC3,NDC1,ABCA3,ATXN3,RAB11B,EIF3D,ANK3,INO80E,GNB2,STAM,APP,PHC2,RAB21,CCNA2,SHC1,SP100,SIAH1,UCHL5,MTA1,NUP107,MAVS,DCTN1,CCT2,SEC61B,VDAC2,RPL38,RAB1A,PSMB9,TAZ,SERP1,CHCHD3,EIF3K,SEC61A1,DDOST,RAB24,NSMCE2,CAMKMT,SEL1L,H2AFX,RPLP1,ATF6,B4GALT3,XRCC4,CSNK1D,DYNC1LI2,USP13,OTUD5,RPS2,B4GALT5,BABAM1,SLC25A12,ATP5F1B,BLM,RAB11A,MAT2B,PSMD2,PTEN,RPL17,ARF5,FUT8,AXIN2,RPL19,ST8SIA2,MTX2,RPL22L1,SPTAN1,TNFAIP3,KAT2A,USP42,RPL8,OTUD3,RHOT1,RPL27A,ARSK,RPA1,YIF1A,HGS,KEAP1,RPL32,MAGT1,PFDN4,TATDN2,PML,KHSRP,ASNA1,ADA2,PIGM,COPA,MOGS,UBE2Z,DNAJC24,CSNK2A1,USP48,BECN1,SEC16A,BIRC2,RNF103,SSR1,RAB8A,NUP210,PCNA,TIMM23,RAB35,JOSD1,EIF5,TIMM50,SP3,EXOSC6,DPM1,SUMF2,BRCA1,RAB5B,USP21,PAF1,ALG3,MAN2A2,RPL37,TIMM13,MIA2,ACTB,GALNT10,NGLY1,RPS26,PSMC1,UBE2D3,RPS15,PIGN,NSMCE4A,GORASP1,UBXN1,CHCHD2,RPL15,RAB6A,B4GALT4,ASXL2,TTF1,NUP205,C1GALT1,UBE2Q2,NUS1,CCP110,CTR9,ZRANB1,ATP6V0D1,KDELR1,PREB,TRAPPC9,TSTA3,GBA,RPL6,PSMA1,RTF1,SYVN1,METTL22,LY6E,RPL36,PSMC4,GALNT2,UAP1,EXOC4,SIAH2,FN3KRP,NUP62,CTSA,ATP5F1A,NANP,USP7,TOMM20,CYLD,GNPNAT1,RPLP2,DYNLL1,SUMO2,COPE,RPL11,USP5,RAD23A,ANKRD28,SEC11A,BABAM2,MDM2,PSMA6,ABRAXAS2,EXOSC1,CS,PPP6C,RPN2,LMAN1,PDIA6,CTDSP2,RPL29,RPL35,BIRC3,PSMA8,RAB7A,PSMB7,NUP155,KDM1B,VDAC1,EDEM2,EIF3G,GFER,RPS9,RPSA,EIF3H,IDE,TIMM17A,PSMD3,TOMM6,USP11,FAU,H3F3A,SMAD4,CBX4,CMAS,RAE1,GNE,DCTN2,CDCA8,NUP54,TIMM21,SMC6,SUMF1,ARF1,GGA2,DNAJB9,MAN1A1,KIF5B,SEC24C,STAT3,SLC35A1,RNF5,MYO5A,TGFB1,MLEC,CNTN5,RHOA,PRKDC,COG1,RANGAP1,NEU1,RAB18,SEC23IP,BIRC5,USP20,MBD6,SPCS3,UBE2C
R-HSA-597592	Post-translational protein modification	2.32092301492207e-12	-26.7890561581126	1034	253	0.149174528301887	1696	10287	51014,51552,93183,23511,1314,5589,9091,7841,65264,120526,54187,84196,7329,8678,9919,329,7844,805,4218,8774,5111,5707,23225,11021,5867,5887,9929,9972,10342,29843,4249,81929,9736,6670,8615,11070,8813,25870,9212,26503,51005,51809,672,23326,90411,23463,5869,27005,57403,84932,378,54623,4122,10195,4087,3703,10972,6233,5714,8312,4253,8473,60,6483,55568,4086,409,55768,5700,8086,8704,23586,7323,23556,54780,63967,64689,1725,51035,51715,2683,7155,23423,5870,8702,55252,5715,26958,79577,23165,57599,9276,966,6184,56913,116150,9126,92912,9738,1603,51564,54872,9646,84282,54764,79902,22870,10959,10945,10113,1984,83696,51604,221937,7264,11253,5682,9100,23168,84447,154,4061,79091,9527,5691,5704,22872,79139,2590,6675,2801,4905,6478,9063,79672,23636,5476,140838,7528,55291,11236,9818,1029,7874,55706,9804,1540,4287,64841,9230,8655,6613,11316,288,283899,8027,5886,8078,23243,1912,23011,9577,4193,5687,890,6672,23172,51377,9112,57122,5537,6185,57506,3998,1639,330,143471,7879,5695,7417,9631,221656,5861,7416,55741,5698,3416,1650,53917,5709,286053,79823,6400,8237,8703,7518,4089,8535,1453,1783,8975,55593,55907,6187,9334,8480,29086,10020,10540,55143,53371,79677,285362,375,641,8766,4121,27430,5708,5728,381,9632,2530,8313,8128,10559,6048,6709,7040,9761,53942,387,7128,2648,5591,84132,9382,5905,23252,55288,153642,4758,6117,22931,9146,9817,11196,84061,332,5371,10868,114785,11065	TMED7,RAB14,PIGM,NUP188,COPA,PRKCSH,PIGQ,MOGS,UBE2Z,DNAJC24,NANS,USP48,UBE2I,BECN1,SEC16A,BIRC2,RNF103,CALM2,RAB8A,NAPG,PCNA,PSMD1,NUP210,RAB35,RAB4A,RAD23B,JOSD1,NUP153,TFG,SENP1,MGAT5,SEH1L,USP34,SP3,USO1,TMEM115,DPM1,SUMF2,AURKB,SLC17A5,AMDHD2,GALNT7,BRCA1,USP22,MCFD2,ICMT,RAB5B,USP21,RAB22A,RAB2B,ARF4,PAF1,MAN2A2,ALG3,SMAD2,STT3A,TMED10,RPS27A,PSMD8,AXIN1,MIA2,OGT,ACTB,ST3GAL2,GALNT10,SMAD1,ARRB2,NGLY1,PSMC1,AAAS,B4GALT2,DDX58,UBE2D3,PIGN,NSMCE4A,CLSPN,GORASP1,DHPS,UBXN1,RAB23,B4GALT1,TOP2B,TMED3,RAB6A,B4GALT4,ASXL2,PSMD9,COPG2,CDC73,NUP205,WDR48,COPB2,CD59,RPN1,C1GALT1,NUS1,SMC3,UBE2Q2,CCP110,DAD1,HDAC7,PIGG,CTR9,RNF135,ZRANB1,NUP85,PPP6R1,TMED2,KDELR1,PREB,EIF5A,TRAPPC9,PIGT,FOXK1,TSTA3,MAN1B1,PSMA1,USP10,RTF1,SYVN1,ADRB2,LY6E,METTL22,GOSR1,PSMB3,PSMC4,SEC31A,DERL1,GALNT2,UAP1,GOLGA2,NSF,SIAH2,PIAS2,FN3KRP,NUP62,CTSA,NANP,YY1,PPP6R3,RNF139,NUP58,CDKN2A,USP7,NDC1,TOMM20,CYLD,ATXN3,GNPNAT1,RAB11B,DYNLL1,SUMO2,COPE,ANK3,INO80E,STAM,RAD23A,USP5,ANKRD28,PHC2,RAB21,BABAM2,MDM2,PSMA6,CCNA2,SP100,ABRAXAS2,UCHL5,MTA1,NUP107,PPP6C,RPN2,MAVS,LMAN1,DCTN1,BIRC3,PSMA8,RAB7A,PSMB7,VDAC2,NUP155,KDM1B,RAB1A,VDAC1,EDEM2,PSMB9,IDE,DDOST,RAB24,PSMD3,NSMCE2,CAMKMT,SEL1L,USP11,B4GALT3,XRCC4,SMAD4,CBX4,CSNK1D,DYNC1LI2,USP13,OTUD5,CMAS,RPS2,B4GALT5,RAE1,BABAM1,GNE,DCTN2,CDCA8,NUP54,SMC6,SUMF1,ARF1,BLM,RAB11A,MAN1A1,MAT2B,PSMD2,PTEN,ARF5,SEC24C,FUT8,AXIN2,ST8SIA2,SLC35A1,RNF5,SPTAN1,TGFB1,MLEC,CNTN5,RHOA,TNFAIP3,KAT2A,PRKDC,USP42,COG1,RANGAP1,OTUD3,RHOT1,ARSK,NEU1,RPA1,RAB18,HGS,KEAP1,SEC23IP,MAGT1,BIRC5,PML,USP20,MBD6,UBE2C
R-HSA-5653656	Vesicle-mediated transport	1.78620867363468e-11	-24.748340708764	650	172	0.101415094339623	1696	10287	51552,51014,1314,7249,10618,3267,11004,29978,9919,81631,57589,3833,805,8774,4218,11021,5867,8907,1785,163,3835,10342,10920,80006,8615,22836,11070,208,56992,90411,8675,5869,378,10133,55707,4122,79735,146909,10972,6233,4253,27183,10980,409,9847,10808,60592,64689,26088,51622,29924,3831,9493,29127,23423,5870,84313,26958,9276,2799,966,10092,112574,126432,23303,22920,22870,10959,8542,10945,10113,2512,9648,9267,83696,154,10552,9527,22872,950,7248,2803,2590,2801,4905,8773,60412,7534,55291,57679,11336,5564,84079,27243,90196,9185,9322,9230,8655,10096,11316,5879,288,143187,22879,54662,162,8027,351,85021,23243,23011,57533,5537,1212,3998,60560,79571,1856,1639,7879,23299,25978,5861,23431,3796,29082,6836,1174,128866,949,1175,1453,1783,9371,27333,10540,11311,23647,56894,375,23062,1176,8766,7037,23396,4121,3799,156,9632,381,64708,4644,6709,6643,163486,55667,9382,117177,3832,8301,22931,9146,81930,11196,9342,221960,53407,91782,7533,5866,23557	RAB14,TMED7,COPA,TSC2,TGOLN2,AGFG1,KIF2C,UBQLN2,SEC16A,MAP1LC3B,RIC1,KIFC1,CALM2,NAPG,RAB8A,RAB35,RAB4A,AP1M1,DNM2,AP2B1,KIF22,TFG,COPS8,TRAPPC13,USO1,RHOBTB3,TMEM115,AKT2,KIF15,MCFD2,STX16,RAB5B,ARF4,OPTN,NECAP2,MAN2A2,TBC1D17,KIF18B,TMED10,RPS27A,MIA2,VPS4A,COPS6,ARRB2,C2CD5,HSPH1,SCOC,GORASP1,GGA1,CCZ1,EPN1,KLC1,KIF23,RACGAP1,TMED3,RAB6A,VPS25,COPG2,COPB2,GNS,CD59,ARPC5,SNX18,RINL,KIF13B,KIFAP3,PPP6R1,TMED2,APOL1,KDELR1,PREB,FTL,GCC2,CYTH1,TRAPPC9,ADRB2,ARPC1A,GOSR1,SEC31A,SCARB2,TSC1,GOLGA4,GALNT2,GOLGA2,NSF,SNAP23,EXOC4,YWHAZ,PPP6R3,ALS2,EXOC3,PRKAB1,ANKRD27,CHMP2A,SYS1,REPS2,TRIP10,RAB11B,DYNLL1,ACTR3,COPE,RAC1,ANK3,VTI1A,MON1B,TBC1D13,AP1B1,STAM,APP,REPS1,ANKRD28,RAB21,TBC1D14,PPP6C,CLTB,LMAN1,NAA35,GCC1,DVL2,DCTN1,RAB7A,BICD2,CHMP2B,RAB1A,AP4E1,KIF2A,CHMP4A,SURF4,AP1S1,CHMP4B,SCARB1,AP2S1,CSNK1D,DYNC1LI2,KIF3B,GOLIM4,DCTN2,VPS45,ARFIP2,AGPAT3,ARF1,GGA2,AP3S1,RAB11A,TFRC,PIP5K1C,MAN1A1,KIF5B,GRK2,SEC24C,ARF5,COPS7B,MYO5A,SPTAN1,SNX2,DENND1B,DENND4C,COG1,RAB3IP,KIF11,PICALM,RAB18,HGS,KIF18A,SEC23IP,SNAP29,CCZ1B,STX18,CHMP7,YWHAH,RAB3IL1,SNAPIN
R-HSA-68886	M Phase	2.97153525033292e-11	-24.2393572843726	308	97	0.0571933962264151	1696	10287	55706,3015,23511,9232,2029,1457,83540,11004,891,79003,5707,25909,23225,5687,10783,9663,57122,23047,51434,9972,81929,23141,5347,8615,143471,57551,5695,9631,9212,10592,8697,5861,5698,94239,79682,3796,5515,8881,5525,79980,6233,5714,5709,3014,3020,5594,5700,55844,8086,22919,64689,8480,1063,55143,53371,9493,11243,54908,5715,64151,23165,4000,26271,5925,5708,9126,387893,8815,9735,79019,79648,79902,10051,10726,140609,5682,29882,26003,5905,5691,5595,5704,84930,221496,81930,996,2801,332,113130,23636,80152,54820,9133,11065,9700,9818,29945	NDC1,H2AFZ,NUP188,PTTG1,ENSA,CSNK2A1,NUF2,KIF2C,CCNB1,MIS12,PSMD1,AHCTF1,NUP210,PSMA6,NEK6,LPIN2,NUP107,PDS5B,ANAPC7,NUP153,SEH1L,ANKLE2,PLK1,USO1,PSMA8,TAOK1,PSMB7,NUP155,AURKB,SMC2,CDC23,RAB1A,PSMB9,H2AFV,CENPU,KIF2A,PPP2CA,CDC16,PPP2R5A,DSN1,RPS27A,PSMD8,PSMD3,H2AFX,H3F3A,MAPK1,PSMC1,PPP2R2D,AAAS,MAPRE1,GORASP1,RAE1,CENPF,CDCA8,NUP54,KIF23,PMF1,SPDL1,PSMD9,NCAPG,NUP205,LMNA,FBXO5,RB1,PSMD2,SMC3,KMT5A,BANF1,KNTC1,CENPM,MCPH1,NUP85,SMC4,NUDC,NEK7,PSMA1,ANAPC2,GORASP2,RANGAP1,PSMB3,MAPK3,PSMC4,MASTL,LEMD2,KIF18A,CDC27,GOLGA2,BIRC5,CDCA5,NUP62,CENPT,NDE1,CCNB2,UBE2C,ESPL1,NUP58,ANAPC4
R-HSA-446203	Asparagine N-linked glycosylation	4.36908621298191e-11	-23.8538821402732	284	91	0.0536556603773585	1696	10287	51014,64841,1314,5589,8655,11316,288,7841,54187,9919,7844,23243,8774,5887,5537,6185,10342,3998,4249,1639,8615,11070,8813,26503,51005,90411,55741,5861,378,4122,10195,1650,3703,10972,6233,6400,4253,6483,8703,55768,5700,1453,8704,1783,55907,64689,9334,51035,10540,10020,2683,375,23423,8702,26958,9276,4121,966,6184,116150,1603,381,9632,2530,8128,22870,10559,10959,6048,10945,6709,10113,83696,9761,7264,11253,9382,84447,9527,4758,22872,79139,11196,2801,84061,6675,4905,5476,140838,55291,11236	TMED7,GNPNAT1,COPA,PRKCSH,DYNLL1,COPE,ANK3,MOGS,NANS,SEC16A,RNF103,ANKRD28,NAPG,RAD23B,PPP6C,RPN2,TFG,LMAN1,MGAT5,DCTN1,USO1,TMEM115,DPM1,SLC17A5,AMDHD2,MCFD2,EDEM2,RAB1A,ARF4,MAN2A2,ALG3,DDOST,STT3A,TMED10,RPS27A,SEL1L,MIA2,ST3GAL2,B4GALT3,NGLY1,PSMC1,CSNK1D,B4GALT2,DYNC1LI2,CMAS,GORASP1,B4GALT5,UBXN1,DCTN2,GNE,B4GALT1,ARF1,TMED3,B4GALT4,COPG2,COPB2,MAN1A1,CD59,RPN1,NUS1,DAD1,ARF5,SEC24C,FUT8,ST8SIA2,PPP6R1,SLC35A1,TMED2,RNF5,KDELR1,SPTAN1,PREB,TRAPPC9,MLEC,TSTA3,MAN1B1,COG1,SYVN1,GOSR1,NEU1,SEC31A,DERL1,SEC23IP,GOLGA2,MAGT1,UAP1,NSF,CTSA,NANP,PPP6R3,RNF139
R-HSA-168254	Influenza Infection	3.49556532721572e-09	-19.4717707212037	157	56	0.0330188679245283	1696	10287	6209,55706,6187,23511,6181,5440,8480,53371,6138,23165,2962,6135,6147,23225,6139,2926,57122,9972,6143,10898,79902,200916,81929,7040,6159,11224,5438,5441,5436,6132,6204,6169,5433,6128,6229,9631,6157,6203,9636,5430,3921,25873,6167,3840,3836,5439,6161,6233,6208,6176,23636,3838,2197,6231,9818,8086	RPS15,NDC1,RPS2,NUP188,RPLP2,POLR2K,RAE1,NUP54,RPL15,NUP205,GTF2F1,RPL11,RPL23A,NUP210,RPL17,GRSF1,NUP107,NUP153,RPL19,CPSF4,NUP85,RPL22L1,SEH1L,TGFB1,RPL29,RPL35,POLR2I,POLR2L,POLR2G,RPL8,RPS10,RPL38,POLR2D,RPL6,RPS24,NUP155,RPL27A,RPS9,ISG15,POLR2A,RPSA,RPL36,RPL37,KPNA4,KPNA1,POLR2J,RPL32,RPS27A,RPS14,RPLP1,NUP62,KPNA2,FAU,RPS26,NUP58,AAAS
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	5.38206851575779e-09	-19.0401930541843	179	61	0.0359669811320755	1696	10287	9371,51014,27333,90196,1314,60592,8655,11316,10540,11311,143187,3831,9493,23647,56894,29127,10618,11004,23423,5870,375,26958,57589,9276,4121,3833,3799,8774,381,23303,22920,3835,60560,79571,10959,10945,1639,9648,9267,22836,56992,9382,23299,5861,8675,9527,3832,378,3796,4122,22931,2803,2590,81930,6836,146909,4905,10972,9342,53407,1783	KIF3B,TMED7,GOLIM4,SYS1,COPA,SCOC,DYNLL1,COPE,DCTN2,VPS45,VTI1A,KLC1,KIF23,ARFIP2,AGPAT3,RACGAP1,TGOLN2,KIF2C,TMED3,RAB6A,ARF1,COPG2,RIC1,COPB2,MAN1A1,KIFC1,KIF5B,NAPG,ARF5,KIF13B,KIFAP3,KIF22,NAA35,GCC1,TMED2,KDELR1,DCTN1,GCC2,CYTH1,RHOBTB3,KIF15,COG1,BICD2,RAB1A,STX16,GOSR1,KIF11,ARF4,KIF2A,MAN2A2,RAB18,GOLGA4,GALNT2,KIF18A,SURF4,KIF18B,NSF,TMED10,SNAP29,STX18,DYNC1LI2
R-HSA-5663205	Infectious disease	6.91190881457312e-09	-18.7900199978677	388	108	0.0636792452830189	1696	10287	27243,55706,10015,23511,6181,5879,162,8027,6135,6147,805,5707,5687,23225,2926,57122,8907,163,9972,6917,81929,6159,11224,5441,5436,143471,9978,5695,6924,6169,5433,9631,25978,5698,292,6203,3921,11198,6873,6167,29082,6233,5714,5709,6208,6176,1174,3838,128866,27183,2197,7518,5700,6231,1175,8086,6749,6209,9150,6187,5440,8480,53371,79872,6138,375,5715,3105,23165,2962,8812,5708,6139,8815,6143,10898,2966,200916,79902,7040,5438,6132,6204,6128,5682,6229,5905,55690,6157,5605,9636,5430,5691,9397,5704,25873,7520,9146,3840,3836,5439,6161,9844,23636,6883,91782,6878,9818	CHMP2A,NDC1,PDCD6IP,NUP188,RPLP2,RAC1,AP1B1,STAM,RPL11,RPL23A,CALM2,PSMD1,PSMA6,NUP210,GRSF1,NUP107,AP1M1,AP2B1,NUP153,TCEA1,SEH1L,RPL29,RPL35,POLR2L,POLR2G,PSMA8,RBX1,PSMB7,ELOA,RPL38,POLR2D,NUP155,CHMP2B,PSMB9,SLC25A5,RPS9,RPSA,SUPT16H,TAF2,RPL37,CHMP4A,RPS27A,PSMD8,PSMD3,RPS14,RPLP1,AP1S1,KPNA2,CHMP4B,VPS4A,FAU,XRCC4,PSMC1,RPS26,AP2S1,AAAS,SSRP1,RPS15,CTDP1,RPS2,POLR2K,RAE1,NUP54,CBLL1,RPL15,ARF1,PSMD9,HLA-A,NUP205,GTF2F1,CCNK,PSMD2,RPL17,BANF1,RPL19,CPSF4,GTF2H2,RPL22L1,NUP85,TGFB1,POLR2I,RPL8,RPS10,RPL6,PSMA1,RPS24,RANGAP1,PACS1,RPL27A,MAP2K2,ISG15,POLR2A,PSMB3,NMT2,PSMC4,RPL36,XRCC5,HGS,KPNA4,KPNA1,POLR2J,RPL32,ELMO1,NUP62,TAF12,CHMP7,TAF6,NUP58
R-HSA-2262752	Cellular responses to stress	9.10722046923373e-09	-18.5141982798876	451	121	0.0713443396226415	1696	10287	27243,5564,55706,3015,7295,23511,6767,7249,29855,6195,23512,8655,64121,81631,1432,8678,1912,54386,1031,4193,5707,890,23225,5687,64422,57122,1027,51434,9972,81929,64223,143471,9978,2077,79065,7428,9448,79813,1871,5695,9631,8697,25978,5698,94239,6009,3308,29082,8881,6233,5714,5709,25824,3014,128866,7029,3020,1870,5594,5700,25913,8535,8086,7323,27000,10808,8480,5562,8649,53371,54205,84335,3337,2113,5715,23165,115201,6118,5925,5708,9776,10728,10370,6774,79902,818,7014,9821,7867,30001,5682,29882,5691,5052,3304,5595,5704,6117,8897,847,7248,996,2114,10935,389541,7027,1869,23636,23523,26100,4217,5928,1017,91782,56270,11065,9818,7013,29945,1029,54583	CHMP2A,PRKAB1,NDC1,H2AFZ,TXN,NUP188,ST13,TSC2,UBN1,RPS6KA1,SUZ12,DYNLL1,RRAGC,MAP1LC3B,MAPK14,BECN1,PHC2,TERF2IP,CDKN2C,MDM2,PSMD1,CCNA2,NUP210,PSMA6,ATG3,NUP107,CDKN1B,ANAPC7,NUP153,SEH1L,MLST8,PSMA8,RBX1,ERF,ATG9A,VHL,MAP4K4,EHMT1,E2F3,PSMB7,NUP155,CDC23,CHMP2B,PSMB9,H2AFV,RHEB,HSPA4,CHMP4A,CDC16,RPS27A,PSMD8,PSMD3,PRDX5,H2AFX,CHMP4B,TFDP2,H3F3A,E2F2,MAPK1,PSMC1,POT1,CBX4,AAAS,UBE2D3,DNAJC2,HSPH1,RAE1,PRKAA1,LAMTOR3,NUP54,CYCS,AKT1S1,DNAJB1,ETS1,PSMD9,NUP205,ATG4A,RPA2,RB1,PSMD2,ATG13,PTGES3,CITED2,STAT3,NUP85,CAMK2G,TERF2,RB1CC1,MAPKAPK3,ERO1A,PSMA1,ANAPC2,PSMB3,PRDX1,HSPA1B,MAPK3,PSMC4,RPA1,MTMR3,CAT,TSC1,CDC27,ETS2,PRDX3,LAMTOR4,TFDP1,E2F1,NUP62,CABIN1,WIPI2,MAP3K5,RBBP4,CDK2,CHMP7,WDR45B,UBE2C,NUP58,TERF1,ANAPC4,CDKN2A,EGLN1
R-HSA-168273	Influenza Viral RNA Transcription and Replication	1.00501800860203e-08	-18.4156752835949	137	50	0.0294811320754717	1696	10287	6209,55706,6187,23511,6181,5440,8480,53371,6138,23165,2962,6135,6147,23225,6139,2926,57122,9972,6143,200916,79902,81929,6159,11224,5438,5441,5436,6132,6169,5433,6128,6204,6229,9631,6157,6203,5430,3921,25873,6167,6161,5439,6233,6208,6176,23636,2197,6231,9818,8086	RPS15,NDC1,RPS2,NUP188,RPLP2,POLR2K,RAE1,NUP54,RPL15,NUP205,GTF2F1,RPL11,RPL23A,NUP210,RPL17,GRSF1,NUP107,NUP153,RPL19,RPL22L1,NUP85,SEH1L,RPL29,RPL35,POLR2I,POLR2L,POLR2G,RPL8,RPL38,POLR2D,RPL6,RPS10,RPS24,NUP155,RPL27A,RPS9,POLR2A,RPSA,RPL36,RPL37,RPL32,POLR2J,RPS27A,RPS14,RPLP1,NUP62,FAU,RPS26,NUP58,AAAS
R-HSA-453279	Mitotic G1-G1/S phases	1.75057356710118e-08	-17.8607372570869	143	51	0.0300707547169811	1696	10287	23649,4149,55388,81620,10926,8454,4998,891,5715,26271,286826,6118,1031,5925,5708,5111,5707,5687,890,4174,1027,23595,5558,208,4605,5695,1871,5682,6241,990,4171,5698,5691,5704,6117,5557,5515,5426,6233,5933,5714,5709,1874,7027,1869,7029,5928,1017,1870,5700,1029	POLA2,MAX,MCM10,CDT1,DBF4,CUL1,ORC1,CCNB1,PSMD9,FBXO5,LIN9,RPA2,CDKN2C,RB1,PSMD2,PCNA,PSMD1,PSMA6,CCNA2,MCM5,CDKN1B,ORC3,PRIM2,AKT2,MYBL2,PSMB7,E2F3,PSMA1,RRM2,CDC6,MCM2,PSMB9,PSMB3,PSMC4,RPA1,PRIM1,PPP2CA,POLE,RPS27A,RBL1,PSMD8,PSMD3,E2F4,TFDP1,E2F1,TFDP2,RBBP4,CDK2,E2F2,PSMC1,CDKN2A
R-HSA-73894	DNA Repair	1.88970589284958e-08	-17.7842595392386	316	91	0.0536556603773585	1696	10287	7874,9682,56949,6613,9557,5395,54890,116028,283899,7329,55215,8930,5886,55120,5111,9577,890,7516,5887,6917,9716,4968,23514,27339,10920,55775,2067,5983,5436,5441,9978,10635,10450,5433,672,64421,5982,2178,5889,56852,6233,80233,3014,9031,3838,7517,60,11200,10980,5536,348654,7518,2139,5892,10721,63967,5440,2138,29086,641,80010,10459,55666,252969,51514,6118,7507,4436,8914,64708,2966,2956,3150,5438,51426,5591,7156,9100,4350,5430,9636,6117,7520,79728,5426,5439,8505,7528,91603,1017,1642	USP7,KDM4A,XAB2,SUMO2,CHD1L,PMS2,ALKBH5,RMI2,INO80E,UBE2I,FANCI,MBD4,RAD23A,FANCL,PCNA,BABAM2,CCNA2,XRCC2,RAD23B,TCEA1,AQR,OGG1,SPIDR,PRPF19,COPS8,TDP1,ERCC1,RFC3,POLR2G,POLR2L,RBX1,RAD51AP1,PPIE,POLR2D,BRCA1,DCLRE1C,RFC2,FANCE,RAD51C,RAD18,RPS27A,FAAP100,H2AFX,BAZ1B,KPNA2,XRCC3,ACTB,CHEK2,COPS6,PPP5C,GEN1,XRCC4,EYA2,RAD51D,POLQ,CLSPN,POLR2K,EYA1,BABAM1,BLM,RMI1,MAD2L2,NPLOC4,NEIL2,DTL,RPA2,XPA,MSH2,TIMELESS,COPS7B,GTF2H2,MSH6,HMGN1,POLR2I,POLK,PRKDC,TOP3A,USP10,MPG,POLR2A,ISG15,RPA1,XRCC5,PALB2,POLE,POLR2J,PARG,YY1,ZNF830,CDK2,DDB1
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	3.61292527179832e-08	-17.1361629751454	158	54	0.0318396226415094	1696	10287	1329,4698,4729,4719,4712,8802,91942,29796,4191,4697,1327,54205,506,522,6389,374291,4724,137682,5164,4723,4695,4710,1431,8801,4715,4728,1537,4696,3945,51300,80219,3419,55863,3939,2739,4701,4967,9551,4707,3029,8050,51660,6390,518,126328,9167,10128,1351,6566,9377,7388,4725,498,3420	COX5B,NDUFA5,NDUFV2,NDUFS1,NDUFB6,SUCLG1,NDUFAF2,UQCR10,MDH2,NDUFA4,COX4I1,CYCS,ATP5F1B,ATP5PF,SDHA,NDUFS7,NDUFS4,NDUFAF6,PDK2,NDUFV1,NDUFA2,NDUFB4,CS,SUCLG2,NDUFB9,NDUFS8,CYC1,NDUFA3,LDHB,TIMMDC1,COQ10B,IDH3A,TMEM126B,LDHA,GLO1,NDUFA7,OGDH,ATP5MF,NDUFB1,HAGH,PDHX,MPC1,SDHB,ATP5MC3,NDUFA11,COX7A2L,LRPPRC,COX8A,SLC16A1,COX5A,UQCRH,NDUFS5,ATP5F1A,IDH3B
R-HSA-168255	Influenza Life Cycle	3.84242784516292e-08	-17.0745763257949	146	51	0.0300707547169811	1696	10287	6209,55706,6187,23511,6181,5440,8480,53371,6138,23165,2962,6135,6147,23225,6139,2926,57122,9972,6143,79902,200916,81929,6159,11224,5438,5441,5436,6132,6169,5433,6128,6204,6229,9631,6157,6203,5430,3921,25873,6167,3836,5439,6161,6233,6208,6176,23636,2197,6231,9818,8086	RPS15,NDC1,RPS2,NUP188,RPLP2,POLR2K,RAE1,NUP54,RPL15,NUP205,GTF2F1,RPL11,RPL23A,NUP210,RPL17,GRSF1,NUP107,NUP153,RPL19,NUP85,RPL22L1,SEH1L,RPL29,RPL35,POLR2I,POLR2L,POLR2G,RPL8,RPL38,POLR2D,RPL6,RPS10,RPS24,NUP155,RPL27A,RPS9,POLR2A,RPSA,RPL36,RPL37,KPNA1,POLR2J,RPL32,RPS27A,RPS14,RPLP1,NUP62,FAU,RPS26,NUP58,AAAS
R-HSA-453274	Mitotic G2-G2/M phases	4.54206916107795e-08	-16.9072980733753	184	60	0.035377358490566	1696	10287	11116,22919,4659,2305,8655,10540,1063,22974,8454,54930,891,984,5566,5715,55142,10844,286826,5708,4218,5707,5687,890,9738,55835,51512,23194,994,80254,1639,5347,143471,9978,4605,114791,5695,1871,5682,9088,79866,5698,728642,5691,5704,10133,93323,5515,5108,6233,5714,5709,4957,1869,8636,54820,5928,1017,9133,5700,203068,1453	FGFR1OP,MAPRE1,PPP1R12A,FOXM1,DYNLL1,DCTN2,CENPF,TPX2,CUL1,HAUS4,CCNB1,CDK11B,PRKACA,PSMD9,HAUS2,TUBGCP2,LIN9,PSMD2,RAB8A,PSMD1,PSMA6,CCNA2,CCP110,CENPJ,GTSE1,FBXL7,CDC25B,CEP63,DCTN1,PLK1,PSMA8,RBX1,MYBL2,TUBGCP5,PSMB7,E2F3,PSMA1,PKMYT1,BORA,PSMB9,CDK11A,PSMB3,PSMC4,OPTN,HAUS8,PPP2CA,PCM1,RPS27A,PSMD8,PSMD3,ODF2,E2F1,SSNA1,NDE1,RBBP4,CDK2,CCNB2,PSMC1,TUBB,CSNK1D
R-HSA-2555396	Mitotic Metaphase and Anaphase	4.77131282410607e-08	-16.8580592517401	180	59	0.0347877358490566	1696	10287	22919,9232,1063,55143,83540,11004,11243,54908,5715,4000,79003,26271,5708,5707,9126,25909,5687,8815,57122,23047,51434,9735,79019,79902,81929,10726,23141,5347,143471,57551,5695,5682,29882,5905,9212,8697,5698,5691,79682,5704,3796,5515,221496,8881,81930,5525,79980,996,332,6233,5714,5709,113130,80152,54820,11065,5700,9700,29945	MAPRE1,PTTG1,CENPF,CDCA8,NUF2,KIF2C,PMF1,SPDL1,PSMD9,LMNA,MIS12,FBXO5,PSMD2,PSMD1,SMC3,AHCTF1,PSMA6,BANF1,NUP107,PDS5B,ANAPC7,KNTC1,CENPM,NUP85,SEH1L,NUDC,ANKLE2,PLK1,PSMA8,TAOK1,PSMB7,PSMA1,ANAPC2,RANGAP1,AURKB,CDC23,PSMB9,PSMB3,CENPU,PSMC4,KIF2A,PPP2CA,LEMD2,CDC16,KIF18A,PPP2R5A,DSN1,CDC27,BIRC5,RPS27A,PSMD8,PSMD3,CDCA5,CENPT,NDE1,UBE2C,PSMC1,ESPL1,ANAPC4
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	5.65892181924413e-08	-16.6874473611827	104	40	0.0235849056603774	1696	10287	55706,54780,23511,8480,6613,53371,55143,79677,7155,641,7329,23165,1912,4193,5111,9126,23225,6672,51564,9112,57122,9972,79902,81929,6670,5905,9631,9212,672,6117,332,286053,9063,5371,23636,7518,9818,8535,1029,8086	NDC1,NSMCE4A,NUP188,RAE1,SUMO2,NUP54,CDCA8,SMC6,TOP2B,BLM,UBE2I,NUP205,PHC2,MDM2,PCNA,SMC3,NUP210,SP100,HDAC7,MTA1,NUP107,NUP153,NUP85,SEH1L,SP3,RANGAP1,NUP155,AURKB,BRCA1,RPA1,BIRC5,NSMCE2,PIAS2,PML,NUP62,XRCC4,NUP58,CBX4,CDKN2A,AAAS
R-HSA-5633007	Regulation of TP53 Activity	9.38785800352407e-08	-16.181263591395	162	54	0.0318396226415094	1696	10287	7874,5564,112858,5562,22974,116028,1457,641,1432,80010,5305,64769,133746,1020,6118,4193,890,27154,387893,5300,26155,29117,7159,64223,5170,1263,5983,208,9219,79813,7156,79837,117584,9212,672,5982,53615,6117,11198,6873,5515,1107,6233,28996,5371,6794,11200,6883,5928,1017,6878,1029,3066,6749	USP7,PRKAB1,TP53RK,PRKAA1,TPX2,RMI2,CSNK2A1,BLM,MAPK14,RMI1,PIP4K2A,MEAF6,JMY,CDK5,RPA2,MDM2,CCNA2,BRPF3,KMT5A,PIN1,NOC2L,BRD7,TP53BP2,MLST8,PDPK1,PLK3,RFC3,AKT2,MTA2,EHMT1,TOP3A,PIP4K2C,RFFL,AURKB,BRCA1,RFC2,MBD3,RPA1,SUPT16H,TAF2,PPP2CA,CHD3,RPS27A,HIPK2,PML,STK11,CHEK2,TAF12,RBBP4,CDK2,TAF6,CDKN2A,HDAC2,SSRP1
R-HSA-68882	Mitotic Anaphase	9.75418482321226e-08	-16.1429843383908	179	58	0.0341981132075472	1696	10287	22919,9232,1063,55143,83540,11004,11243,54908,5715,4000,79003,5708,5707,9126,25909,5687,8815,57122,23047,51434,9735,79019,79902,81929,10726,23141,5347,143471,57551,5695,5682,29882,5905,9212,8697,5698,5691,79682,5704,3796,5515,221496,8881,81930,5525,79980,996,332,6233,5714,5709,113130,80152,54820,11065,5700,9700,29945	MAPRE1,PTTG1,CENPF,CDCA8,NUF2,KIF2C,PMF1,SPDL1,PSMD9,LMNA,MIS12,PSMD2,PSMD1,SMC3,AHCTF1,PSMA6,BANF1,NUP107,PDS5B,ANAPC7,KNTC1,CENPM,NUP85,SEH1L,NUDC,ANKLE2,PLK1,PSMA8,TAOK1,PSMB7,PSMA1,ANAPC2,RANGAP1,AURKB,CDC23,PSMB9,PSMB3,CENPU,PSMC4,KIF2A,PPP2CA,LEMD2,CDC16,KIF18A,PPP2R5A,DSN1,CDC27,BIRC5,RPS27A,PSMD8,PSMD3,CDCA5,CENPT,NDE1,UBE2C,PSMC1,ESPL1,ANAPC4
R-HSA-8856688	Golgi-to-ER retrograde transport	1.08091114015642e-07	-16.0402913172004	110	41	0.0241745283018868	1696	10287	9371,51014,1314,8655,11316,10540,3831,9493,56894,29127,11004,23423,5870,375,26958,9276,3833,3799,8774,381,23303,22920,3835,10959,10945,1639,56992,23299,5861,3832,378,3796,22931,81930,2590,6836,146909,4905,10972,53407,1783	KIF3B,TMED7,COPA,DYNLL1,COPE,DCTN2,KLC1,KIF23,AGPAT3,RACGAP1,KIF2C,TMED3,RAB6A,ARF1,COPG2,COPB2,KIFC1,KIF5B,NAPG,ARF5,KIF13B,KIFAP3,KIF22,TMED2,KDELR1,DCTN1,KIF15,BICD2,RAB1A,KIF11,ARF4,KIF2A,RAB18,KIF18A,GALNT2,SURF4,KIF18B,NSF,TMED10,STX18,DYNC1LI2
R-HSA-2990846	SUMOylation	1.08091114015642e-07	-16.0402913172004	110	41	0.0241745283018868	1696	10287	55706,54780,23511,8480,6613,53371,55143,79677,7155,641,7329,23165,1912,4193,5111,9126,23225,6672,51564,9112,57122,9972,29843,79902,81929,6670,5905,9631,9212,672,6117,332,286053,9063,5371,23636,7518,9818,8535,1029,8086	NDC1,NSMCE4A,NUP188,RAE1,SUMO2,NUP54,CDCA8,SMC6,TOP2B,BLM,UBE2I,NUP205,PHC2,MDM2,PCNA,SMC3,NUP210,SP100,HDAC7,MTA1,NUP107,NUP153,SENP1,NUP85,SEH1L,SP3,RANGAP1,NUP155,AURKB,BRCA1,RPA1,BIRC5,NSMCE2,PIAS2,PML,NUP62,XRCC4,NUP58,CBX4,CDKN2A,AAAS
R-HSA-162906	HIV Infection	1.08626813500578e-07	-16.0353475584431	236	71	0.0418632075471698	1696	10287	27243,55706,10015,23511,5879,162,5707,23225,5687,57122,8907,163,9972,6917,81929,5441,5436,143471,9978,5695,6924,5433,9631,25978,5698,292,11198,6873,29082,6233,5714,5709,1174,128866,27183,7518,5700,1175,8086,6749,9150,5440,8480,53371,375,5715,3105,23165,2962,8812,5708,8815,2966,79902,5438,5682,5905,55690,5430,9397,5691,7520,5704,3836,5439,9844,23636,6883,6878,91782,9818	CHMP2A,NDC1,PDCD6IP,NUP188,RAC1,AP1B1,PSMD1,NUP210,PSMA6,NUP107,AP1M1,AP2B1,NUP153,TCEA1,SEH1L,POLR2L,POLR2G,PSMA8,RBX1,PSMB7,ELOA,POLR2D,NUP155,CHMP2B,PSMB9,SLC25A5,SUPT16H,TAF2,CHMP4A,RPS27A,PSMD8,PSMD3,AP1S1,CHMP4B,VPS4A,XRCC4,PSMC1,AP2S1,AAAS,SSRP1,CTDP1,POLR2K,RAE1,NUP54,ARF1,PSMD9,HLA-A,NUP205,GTF2F1,CCNK,PSMD2,BANF1,GTF2H2,NUP85,POLR2I,PSMA1,RANGAP1,PACS1,POLR2A,NMT2,PSMB3,XRCC5,PSMC4,KPNA1,POLR2J,ELMO1,NUP62,TAF12,TAF6,CHMP7,NUP58
R-HSA-168325	Viral Messenger RNA Synthesis	1.61309624498154e-07	-15.6399401852869	43	22	0.0129716981132075	1696	10287	55706,5438,23511,5436,5441,5440,8480,53371,5433,9631,5430,23165,2962,23225,5439,57122,23636,9972,9818,79902,81929,8086	NDC1,POLR2I,NUP188,POLR2G,POLR2L,POLR2K,RAE1,NUP54,POLR2D,NUP155,POLR2A,NUP205,GTF2F1,NUP210,POLR2J,NUP107,NUP62,NUP153,NUP58,NUP85,SEH1L,AAAS
R-HSA-69275	G2/M Transition	1.85808558771981e-07	-15.4985489471928	182	58	0.0341981132075472	1696	10287	11116,22919,4659,2305,8655,10540,1063,22974,8454,54930,891,984,5566,5715,55142,10844,286826,5708,4218,5707,5687,890,9738,55835,51512,23194,994,80254,1639,5347,143471,9978,4605,114791,5695,5682,9088,79866,5698,728642,5691,5704,10133,93323,5515,5108,6233,5714,5709,4957,8636,54820,5928,1017,9133,5700,203068,1453	FGFR1OP,MAPRE1,PPP1R12A,FOXM1,DYNLL1,DCTN2,CENPF,TPX2,CUL1,HAUS4,CCNB1,CDK11B,PRKACA,PSMD9,HAUS2,TUBGCP2,LIN9,PSMD2,RAB8A,PSMD1,PSMA6,CCNA2,CCP110,CENPJ,GTSE1,FBXL7,CDC25B,CEP63,DCTN1,PLK1,PSMA8,RBX1,MYBL2,TUBGCP5,PSMB7,PSMA1,PKMYT1,BORA,PSMB9,CDK11A,PSMB3,PSMC4,OPTN,HAUS8,PPP2CA,PCM1,RPS27A,PSMD8,PSMD3,ODF2,SSNA1,NDE1,RBBP4,CDK2,CCNB2,PSMC1,TUBB,CSNK1D
R-HSA-69306	DNA Replication	2.50385124034542e-07	-15.200265608293	109	40	0.0235849056603774	1696	10287	23649,55388,81620,10926,4998,5715,6118,5925,5708,5111,5707,5687,890,4174,1027,23595,9837,5983,5558,143471,5695,1871,5682,990,4171,5698,5982,5691,84296,5557,6117,5704,5426,6233,5709,5714,1869,1017,1870,5700	POLA2,MCM10,CDT1,DBF4,ORC1,PSMD9,RPA2,RB1,PSMD2,PCNA,PSMD1,PSMA6,CCNA2,MCM5,CDKN1B,ORC3,GINS1,RFC3,PRIM2,PSMA8,PSMB7,E2F3,PSMA1,CDC6,MCM2,PSMB9,RFC2,PSMB3,GINS4,PRIM1,RPA1,PSMC4,POLE,RPS27A,PSMD3,PSMD8,E2F1,CDK2,E2F2,PSMC1
R-HSA-1643685	Disease	3.19363024443238e-07	-14.9569373735424	859	196	0.115566037735849	1696	10287	142678,892,11116,10015,23511,375790,7249,4763,102,56922,8454,2992,27044,6147,805,1020,5906,5707,23225,5296,8907,163,9972,994,6917,26127,81929,11140,64223,4893,51107,9978,208,6924,4041,292,6167,4087,6233,5714,8312,6208,399687,3838,27183,409,5700,6231,29080,3066,8086,823,6749,6209,4594,57085,5440,6383,6138,4853,83464,5715,7270,4000,23165,2280,51564,8815,9794,10898,79902,5438,55109,10613,6204,6128,5682,6229,3845,84447,8087,5605,4548,9636,5691,9397,5704,25873,7520,79139,3836,5439,2801,1445,23636,9818,56829,25974,55706,27243,6181,831,5894,5879,162,8027,351,51293,7957,6135,7409,4193,5687,6464,2926,1185,57122,1027,6159,11224,5441,5436,143471,5695,5433,6169,9631,25978,5698,6203,3921,11198,5515,6873,29082,5525,5709,6400,6772,6176,1174,128866,148022,2197,7518,5594,1175,4089,9612,9150,6187,8480,53371,22906,8315,79872,375,84335,1452,2309,8323,3105,2962,8812,824,5708,2261,6139,5781,6143,1385,2966,6774,200916,6048,7040,5170,6868,2648,6132,5905,55690,6157,23499,5052,5430,5595,9146,3840,6161,9844,3516,6883,91782,6878,3265	MIB2,CCNC,FGFR1OP,PDCD6IP,NUP188,AGRN,TSC2,NF1,ADAM10,MCCC1,CUL1,GYG1,SND1,RPL23A,CALM2,CDK5,RAP1A,PSMD1,NUP210,PIK3R2,AP1M1,AP2B1,NUP153,CDC25B,TCEA1,FGFR1OP2,SEH1L,CDC37,MLST8,NRAS,APH1A,RBX1,AKT2,ELOA,LRP5,SLC25A5,RPL37,SMAD2,RPS27A,PSMD8,AXIN1,RPS14,MYO18A,KPNA2,VPS4A,ARRB2,PSMC1,RPS26,CCDC59,HDAC2,AAAS,CAPN1,SSRP1,RPS15,MUT,AGTRAP,POLR2K,SDC2,RPL15,NOTCH2,APH1B,PSMD9,TTF1,LMNA,NUP205,FKBP1A,HDAC7,BANF1,MAML1,CPSF4,NUP85,POLR2I,AGGF1,ERLIN1,RPS10,RPL6,PSMA1,RPS24,KRAS,SYVN1,FXR1,MAP2K2,MTR,ISG15,PSMB3,NMT2,PSMC4,RPL36,XRCC5,DERL1,KPNA1,POLR2J,GOLGA2,CSK,NUP62,NUP58,ZC3HAV1,MMACHC,NDC1,CHMP2A,RPLP2,CAST,RAF1,RAC1,AP1B1,STAM,APP,CD320,EPM2A,RPL11,VAV1,MDM2,PSMA6,SHC1,GRSF1,CLCN6,NUP107,CDKN1B,RPL29,RPL35,POLR2L,POLR2G,PSMA8,PSMB7,POLR2D,RPL38,NUP155,CHMP2B,PSMB9,RPS9,RPSA,SUPT16H,PPP2CA,TAF2,CHMP4A,PPP2R5A,PSMD3,SEL1L,STAT1,RPLP1,AP1S1,CHMP4B,TICAM1,FAU,XRCC4,MAPK1,AP2S1,SMAD4,NCOR2,CTDP1,RPS2,RAE1,NUP54,TRAK1,BRAP,CBLL1,ARF1,AKT1S1,CSNK1A1,FOXO3,FZD6,HLA-A,GTF2F1,CCNK,CAPN2,PSMD2,FGFR3,RPL17,PTPN11,RPL19,CREB1,GTF2H2,STAT3,RPL22L1,RNF5,TGFB1,PDPK1,ADAM17,KAT2A,RPL8,RANGAP1,PACS1,RPL27A,MACF1,PRDX1,POLR2A,MAPK3,HGS,KPNA4,RPL32,ELMO1,RBPJ,TAF12,CHMP7,TAF6,HRAS
R-HSA-2467813	Separation of Sister Chromatids	3.59109009384322e-07	-14.8396398472396	168	54	0.0318396226415094	1696	10287	22919,9232,1063,55143,83540,11004,11243,54908,5715,79003,5708,5707,9126,25909,5687,57122,23047,51434,9735,79019,79902,81929,10726,5347,143471,57551,5695,5682,29882,5905,9212,8697,5698,5691,79682,5704,5515,3796,81930,8881,5525,79980,996,332,6233,5714,5709,113130,80152,54820,11065,5700,9700,29945	MAPRE1,PTTG1,CENPF,CDCA8,NUF2,KIF2C,PMF1,SPDL1,PSMD9,MIS12,PSMD2,PSMD1,SMC3,AHCTF1,PSMA6,NUP107,PDS5B,ANAPC7,KNTC1,CENPM,NUP85,SEH1L,NUDC,PLK1,PSMA8,TAOK1,PSMB7,PSMA1,ANAPC2,RANGAP1,AURKB,CDC23,PSMB9,PSMB3,CENPU,PSMC4,PPP2CA,KIF2A,KIF18A,CDC16,PPP2R5A,DSN1,CDC27,BIRC5,RPS27A,PSMD8,PSMD3,CDCA5,CENPT,NDE1,UBE2C,PSMC1,ESPL1,ANAPC4
R-HSA-948021	Transport to the Golgi and subsequent modification	3.79499951917255e-07	-14.784411366811	164	53	0.03125	1696	10287	51014,1314,64689,8655,9334,11316,10540,288,2683,23423,375,8702,9919,26958,9276,4121,23243,966,8774,9632,381,2530,5537,10342,8128,3998,22870,4249,10959,10945,10113,1639,6709,8615,83696,11070,9382,90411,5861,9527,378,22872,4122,11196,2801,4905,10972,4253,8703,55291,1453,8704,1783	TMED7,COPA,GORASP1,DYNLL1,B4GALT5,COPE,DCTN2,ANK3,B4GALT1,TMED3,ARF1,B4GALT4,SEC16A,COPG2,COPB2,MAN1A1,ANKRD28,CD59,NAPG,SEC24C,ARF5,FUT8,PPP6C,TFG,ST8SIA2,LMAN1,PPP6R1,MGAT5,TMED2,KDELR1,PREB,DCTN1,SPTAN1,USO1,TRAPPC9,TMEM115,COG1,MCFD2,RAB1A,GOSR1,ARF4,SEC31A,MAN2A2,SEC23IP,GOLGA2,NSF,TMED10,MIA2,B4GALT3,PPP6R3,CSNK1D,B4GALT2,DYNC1LI2
R-HSA-69206	G1/S Transition	4.3644722638599e-07	-14.6445983707263	119	42	0.0247641509433962	1696	10287	23649,4149,55388,81620,10926,8454,4998,891,5715,26271,6118,5925,5708,5111,5707,5687,890,4174,1027,23595,5558,208,5695,5682,6241,990,4171,5698,5691,5704,5557,6117,5515,5426,6233,5714,5709,7027,1869,7029,1017,5700	POLA2,MAX,MCM10,CDT1,DBF4,CUL1,ORC1,CCNB1,PSMD9,FBXO5,RPA2,RB1,PSMD2,PCNA,PSMD1,PSMA6,CCNA2,MCM5,CDKN1B,ORC3,PRIM2,AKT2,PSMB7,PSMA1,RRM2,CDC6,MCM2,PSMB9,PSMB3,PSMC4,PRIM1,RPA1,PPP2CA,POLE,RPS27A,PSMD8,PSMD3,TFDP1,E2F1,TFDP2,CDK2,PSMC1
R-HSA-6782135	Dual incision in TC-NER	5.28315340796284e-07	-14.4535724951582	66	28	0.0165094339622642	1696	10287	7874,2067,3150,5983,5438,5436,5441,5440,9978,51426,56949,10450,5433,5982,5430,6117,6118,5111,5426,5439,6233,7507,6917,9716,91603,2966,1642,27339	USP7,ERCC1,HMGN1,RFC3,POLR2I,POLR2G,POLR2L,POLR2K,RBX1,POLK,XAB2,PPIE,POLR2D,RFC2,POLR2A,RPA1,RPA2,PCNA,POLE,POLR2J,RPS27A,XPA,TCEA1,AQR,ZNF830,GTF2H2,DDB1,PRPF19
R-HSA-4615885	SUMOylation of DNA replication proteins	7.30221199471059e-07	-14.1299183357291	46	22	0.0129716981132075	1696	10287	55706,23511,8480,6613,53371,55143,7155,5905,9631,9212,7329,23165,5111,23225,332,57122,23636,9972,79902,9818,81929,8086	NDC1,NUP188,RAE1,SUMO2,NUP54,CDCA8,TOP2B,RANGAP1,NUP155,AURKB,UBE2I,NUP205,PCNA,NUP210,BIRC5,NUP107,NUP62,NUP153,NUP85,NUP58,SEH1L,AAAS
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	7.5109614829953e-07	-14.101732166347	78	31	0.0182783018867925	1696	10287	55706,54780,23511,8480,6613,53371,79677,9631,672,641,7329,23165,6117,1912,9126,23225,6672,51564,286053,5371,57122,9063,23636,9972,7518,9818,79902,8535,81929,8086,1029	NDC1,NSMCE4A,NUP188,RAE1,SUMO2,NUP54,SMC6,NUP155,BRCA1,BLM,UBE2I,NUP205,RPA1,PHC2,SMC3,NUP210,SP100,HDAC7,NSMCE2,PML,NUP107,PIAS2,NUP62,NUP153,XRCC4,NUP58,NUP85,CBX4,SEH1L,AAAS,CDKN2A
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	8.11077340876958e-07	-14.0249024225481	82	32	0.0188679245283019	1696	10287	9371,51014,1314,11316,3831,9493,29127,11004,23423,375,26958,9276,3833,3799,8774,381,23303,3835,22920,10959,10945,56992,5861,3832,378,3796,81930,6836,146909,10972,4905,53407	KIF3B,TMED7,COPA,COPE,KLC1,KIF23,RACGAP1,KIF2C,TMED3,ARF1,COPG2,COPB2,KIFC1,KIF5B,NAPG,ARF5,KIF13B,KIF22,KIFAP3,TMED2,KDELR1,KIF15,RAB1A,KIF11,ARF4,KIF2A,KIF18A,SURF4,KIF18B,TMED10,NSF,STX18
R-HSA-191859	snRNP Assembly	8.12124654064261e-07	-14.0236119937095	53	24	0.0141509433962264	1696	10287	55706,23511,8480,6628,53371,11218,9631,6634,23165,1207,25929,23225,10073,57122,79833,23636,9972,50628,6637,79902,9818,8086,81929,79760	NDC1,NUP188,RAE1,SNRPB,NUP54,DDX20,NUP155,SNRPD3,NUP205,CLNS1A,GEMIN5,NUP210,SNUPN,NUP107,GEMIN6,NUP62,NUP153,GEMIN4,SNRPG,NUP85,NUP58,AAAS,SEH1L,GEMIN7
R-HSA-194441	Metabolism of non-coding RNA	8.12124654064261e-07	-14.0236119937095	53	24	0.0141509433962264	1696	10287	55706,23511,8480,6628,53371,11218,9631,6634,23165,1207,25929,23225,10073,57122,79833,23636,9972,50628,6637,79902,9818,8086,81929,79760	NDC1,NUP188,RAE1,SNRPB,NUP54,DDX20,NUP155,SNRPD3,NUP205,CLNS1A,GEMIN5,NUP210,SNUPN,NUP107,GEMIN6,NUP62,NUP153,GEMIN4,SNRPG,NUP85,NUP58,AAAS,SEH1L,GEMIN7
R-HSA-72165	mRNA Splicing - Minor Pathway	8.12124654064261e-07	-14.0236119937095	53	24	0.0141509433962264	1696	10287	23020,5438,5436,5441,5440,23451,6628,6431,51639,5433,6634,10081,10907,5430,6426,2962,9416,10992,79622,5439,9343,4904,6637,11325	SNRNP200,POLR2I,POLR2G,POLR2L,POLR2K,SF3B1,SNRPB,SRSF6,SF3B6,POLR2D,SNRPD3,PDCD7,TXNL4A,POLR2A,SRSF1,GTF2F1,DDX23,SF3B2,SNRNP25,POLR2J,EFTUD2,YBX1,SNRPG,DDX42
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	9.60720439549031e-07	-13.8555823760737	75	30	0.017688679245283	1696	10287	9295,84248,55706,51362,84324,29107,23511,9984,8480,6431,9939,10921,53371,9631,6430,10212,23165,6426,23225,9775,6429,57122,23636,9972,6428,26097,9818,79902,8086,81929	SRSF11,FYTTD1,NDC1,CDC40,SARNP,NXT1,NUP188,THOC1,RAE1,SRSF6,RBM8A,RNPS1,NUP54,NUP155,SRSF5,DDX39A,NUP205,SRSF1,NUP210,EIF4A3,SRSF4,NUP107,NUP62,NUP153,SRSF3,CHTOP,NUP58,NUP85,AAAS,SEH1L
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	1.04311790537024e-06	-13.7732963438762	79	31	0.0182783018867925	1696	10287	10920,7874,2067,3150,5983,5438,5436,5441,5440,9978,51426,56949,10450,5433,5982,5430,6117,6118,5111,5426,5439,6233,7507,64708,6917,9716,10980,91603,2966,1642,27339	COPS8,USP7,ERCC1,HMGN1,RFC3,POLR2I,POLR2G,POLR2L,POLR2K,RBX1,POLK,XAB2,PPIE,POLR2D,RFC2,POLR2A,RPA1,RPA2,PCNA,POLE,POLR2J,RPS27A,XPA,COPS7B,TCEA1,AQR,COPS6,ZNF830,GTF2H2,DDB1,PRPF19
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	1.17184584648373e-06	-13.6569304057643	87	33	0.0194575471698113	1696	10287	55706,51362,84324,23511,9984,8480,6431,9939,53371,23165,23225,9775,6429,57122,9972,10898,26097,79902,81929,84248,9295,29107,10921,7884,9631,6430,10212,8189,6426,23636,6428,9818,8086	NDC1,CDC40,SARNP,NUP188,THOC1,RAE1,SRSF6,RBM8A,NUP54,NUP205,NUP210,EIF4A3,SRSF4,NUP107,NUP153,CPSF4,CHTOP,NUP85,SEH1L,FYTTD1,SRSF11,NXT1,RNPS1,SLBP,NUP155,SRSF5,DDX39A,SYMPK,SRSF1,NUP62,SRSF3,NUP58,AAAS
R-HSA-611105	Respiratory electron transport	1.62894470656182e-06	-13.3275781720992	92	34	0.0200471698113208	1696	10287	1329,4698,4729,4719,4712,91942,29796,4697,1327,54205,6389,374291,4724,137682,4723,4695,4710,4715,4728,1537,4696,51300,55863,80219,4701,4707,6390,9167,126328,1351,10128,9377,7388,4725	COX5B,NDUFA5,NDUFV2,NDUFS1,NDUFB6,NDUFAF2,UQCR10,NDUFA4,COX4I1,CYCS,SDHA,NDUFS7,NDUFS4,NDUFAF6,NDUFV1,NDUFA2,NDUFB4,NDUFB9,NDUFS8,CYC1,NDUFA3,TIMMDC1,TMEM126B,COQ10B,NDUFA7,NDUFB1,SDHB,COX7A2L,NDUFA11,COX8A,LRPPRC,COX5A,UQCRH,NDUFS5
R-HSA-5696398	Nucleotide Excision Repair	1.64722871174441e-06	-13.3164162507483	112	39	0.0229952830188679	1696	10287	7874,5440,56949,6613,9557,283899,7329,5886,6118,5111,5887,7507,64708,6917,9716,2966,27339,10920,2067,3150,5438,5983,5441,5436,51426,9978,10450,5433,5982,5430,6117,5426,5439,6233,60,10980,7528,91603,1642	USP7,POLR2K,XAB2,SUMO2,CHD1L,INO80E,UBE2I,RAD23A,RPA2,PCNA,RAD23B,XPA,COPS7B,TCEA1,AQR,GTF2H2,PRPF19,COPS8,ERCC1,HMGN1,POLR2I,RFC3,POLR2L,POLR2G,POLK,RBX1,PPIE,POLR2D,RFC2,POLR2A,RPA1,POLE,POLR2J,RPS27A,ACTB,COPS6,YY1,ZNF830,DDB1
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	1.97572648910584e-06	-13.1345743846635	35	18	0.0106132075471698	1696	10287	55706,23511,140609,8480,53371,9631,891,23165,23225,10783,57122,23636,9972,9133,79902,9818,81929,8086	NDC1,NUP188,NEK7,RAE1,NUP54,NUP155,CCNB1,NUP205,NUP210,NEK6,NUP107,NUP62,NUP153,CCNB2,NUP85,NUP58,SEH1L,AAAS
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	2.12103852723634e-06	-13.0636047178903	113	39	0.0229952830188679	1696	10287	1329,4698,4729,4719,4712,91942,29796,4697,1327,54205,506,522,6389,374291,4724,137682,4723,4695,4710,4715,4728,1537,4696,51300,55863,80219,4701,9551,4707,6390,518,9167,126328,1351,10128,9377,7388,498,4725	COX5B,NDUFA5,NDUFV2,NDUFS1,NDUFB6,NDUFAF2,UQCR10,NDUFA4,COX4I1,CYCS,ATP5F1B,ATP5PF,SDHA,NDUFS7,NDUFS4,NDUFAF6,NDUFV1,NDUFA2,NDUFB4,NDUFB9,NDUFS8,CYC1,NDUFA3,TIMMDC1,TMEM126B,COQ10B,NDUFA7,ATP5MF,NDUFB1,SDHB,ATP5MC3,COX7A2L,NDUFA11,COX8A,LRPPRC,COX5A,UQCRH,ATP5F1A,NDUFS5
R-HSA-2980766	Nuclear Envelope Breakdown	2.27633618161359e-06	-12.9929433453962	52	23	0.013561320754717	1696	10287	5347,55706,23511,140609,8480,53371,9631,891,23165,4000,221496,23225,10783,8815,9663,57122,23636,9972,9133,79902,9818,8086,81929	PLK1,NDC1,NUP188,NEK7,RAE1,NUP54,NUP155,CCNB1,NUP205,LMNA,LEMD2,NUP210,NEK6,BANF1,LPIN2,NUP107,NUP62,NUP153,CCNB2,NUP85,NUP58,AAAS,SEH1L
R-HSA-168253	Host Interactions with Influenza Factors	2.54202594363942e-06	-12.882549179254	42	20	0.0117924528301887	1696	10287	7040,55706,23511,8480,53371,9631,9636,23165,3840,3836,23225,57122,23636,3838,9972,10898,9818,79902,81929,8086	TGFB1,NDC1,NUP188,RAE1,NUP54,NUP155,ISG15,NUP205,KPNA4,KPNA1,NUP210,NUP107,NUP62,KPNA2,NUP153,CPSF4,NUP58,NUP85,SEH1L,AAAS
R-HSA-68874	M/G1 Transition	2.76065050930523e-06	-12.8000442142289	86	32	0.0188679245283019	1696	10287	23649,55388,81620,10926,4998,5715,6118,5708,5707,5687,4174,23595,5558,143471,5695,1871,5682,990,4171,5698,5691,5557,6117,5704,5426,6233,5709,5714,1869,1870,1017,5700	POLA2,MCM10,CDT1,DBF4,ORC1,PSMD9,RPA2,PSMD2,PSMD1,PSMA6,MCM5,ORC3,PRIM2,PSMA8,PSMB7,E2F3,PSMA1,CDC6,MCM2,PSMB9,PSMB3,PRIM1,RPA1,PSMC4,POLE,RPS27A,PSMD3,PSMD8,E2F1,E2F2,CDK2,PSMC1
R-HSA-69002	DNA Replication Pre-Initiation	2.76065050930523e-06	-12.8000442142289	86	32	0.0188679245283019	1696	10287	23649,55388,81620,10926,4998,5715,6118,5708,5707,5687,4174,23595,5558,143471,5695,1871,5682,990,4171,5698,5691,5557,6117,5704,5426,6233,5709,5714,1869,1870,1017,5700	POLA2,MCM10,CDT1,DBF4,ORC1,PSMD9,RPA2,PSMD2,PSMD1,PSMA6,MCM5,ORC3,PRIM2,PSMA8,PSMB7,E2F3,PSMA1,CDC6,MCM2,PSMB9,PSMB3,PRIM1,RPA1,PSMC4,POLE,RPS27A,PSMD3,PSMD8,E2F1,E2F2,CDK2,PSMC1
R-HSA-72766	Translation	3.63752853763462e-06	-12.5242060800996	162	50	0.0294811320754717	1696	10287	6209,6187,6181,23480,8664,23708,6138,6135,6745,6147,23478,6184,8894,6139,6185,6143,1983,26986,200916,1936,6731,6159,51386,11224,10952,6132,6169,6128,6204,6746,6229,6157,7458,8666,6203,3921,8667,8661,25873,27335,6167,1650,6161,29927,6233,6208,6176,60559,2197,6231	RPS15,RPS2,RPLP2,SEC61G,EIF3D,GSPT2,RPL15,RPL11,SSR1,RPL23A,SEC11A,RPN1,EIF2S2,RPL17,RPN2,RPL19,EIF5,PABPC1,RPL22L1,EEF1D,SRP72,RPL29,EIF3L,RPL35,SEC61B,RPL8,RPL38,RPL6,RPS10,SSR2,RPS24,RPL27A,EIF4H,EIF3G,RPS9,RPSA,EIF3H,EIF3A,RPL36,EIF3K,RPL37,DDOST,RPL32,SEC61A1,RPS27A,RPS14,RPLP1,SPCS3,FAU,RPS26
R-HSA-199977	ER to Golgi Anterograde Transport	4.6169596042063e-06	-12.2857741638374	133	43	0.0253537735849057	1696	10287	51014,1314,64689,8655,11316,10540,288,23423,375,9919,26958,9276,23243,966,8774,9632,381,5537,10342,3998,22870,10959,10945,10113,1639,6709,8615,11070,83696,9382,90411,5861,9527,378,22872,11196,2801,4905,10972,4253,55291,1453,1783	TMED7,COPA,GORASP1,DYNLL1,COPE,DCTN2,ANK3,TMED3,ARF1,SEC16A,COPG2,COPB2,ANKRD28,CD59,NAPG,SEC24C,ARF5,PPP6C,TFG,LMAN1,PPP6R1,TMED2,KDELR1,PREB,DCTN1,SPTAN1,USO1,TMEM115,TRAPPC9,COG1,MCFD2,RAB1A,GOSR1,ARF4,SEC31A,SEC23IP,GOLGA2,NSF,TMED10,MIA2,PPP6R3,CSNK1D,DYNC1LI2
R-HSA-168276	NS1 Mediated Effects on Host Pathways	4.74706921207818e-06	-12.257983138329	40	19	0.0112028301886792	1696	10287	55706,23511,8480,53371,9631,9636,23165,3836,23225,3840,57122,23636,3838,9972,10898,9818,79902,81929,8086	NDC1,NUP188,RAE1,NUP54,NUP155,ISG15,NUP205,KPNA1,NUP210,KPNA4,NUP107,NUP62,KPNA2,NUP153,CPSF4,NUP58,NUP85,SEH1L,AAAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	5.00437378129344e-06	-12.2051982716478	54	23	0.013561320754717	1696	10287	10920,7874,3150,5438,5436,5441,5440,9978,56949,10450,5433,5430,5439,6233,7507,64708,6917,9716,10980,91603,2966,1642,27339	COPS8,USP7,HMGN1,POLR2I,POLR2G,POLR2L,POLR2K,RBX1,XAB2,PPIE,POLR2D,POLR2A,POLR2J,RPS27A,XPA,COPS7B,TCEA1,AQR,COPS6,ZNF830,GTF2H2,DDB1,PRPF19
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	5.03634370545251e-06	-12.1988301944184	65	26	0.0153301886792453	1696	10287	7874,3150,5983,5438,5436,5441,5440,9978,51426,56949,10450,5433,5982,5430,6117,6118,5111,5426,5439,6233,6917,9716,91603,2966,1642,27339	USP7,HMGN1,RFC3,POLR2I,POLR2G,POLR2L,POLR2K,RBX1,POLK,XAB2,PPIE,POLR2D,RFC2,POLR2A,RPA1,RPA2,PCNA,POLE,POLR2J,RPS27A,TCEA1,AQR,ZNF830,GTF2H2,DDB1,PRPF19
R-HSA-162909	Host Interactions of HIV factors	5.73188246684035e-06	-12.0694665529468	134	43	0.0253537735849057	1696	10287	55706,23511,8480,5879,53371,375,162,5715,23165,3105,5708,5707,23225,5687,8815,57122,8907,163,9972,79902,81929,9978,143471,5695,5682,9631,5905,55690,5698,292,5691,5704,3836,6233,9844,5714,5709,1174,23636,5700,9818,1175,8086	NDC1,NUP188,RAE1,RAC1,NUP54,ARF1,AP1B1,PSMD9,NUP205,HLA-A,PSMD2,PSMD1,NUP210,PSMA6,BANF1,NUP107,AP1M1,AP2B1,NUP153,NUP85,SEH1L,RBX1,PSMA8,PSMB7,PSMA1,NUP155,RANGAP1,PACS1,PSMB9,SLC25A5,PSMB3,PSMC4,KPNA1,RPS27A,ELMO1,PSMD8,PSMD3,AP1S1,NUP62,PSMC1,NUP58,AP2S1,AAAS
R-HSA-69239	Synthesis of DNA	6.28569436732828e-06	-11.9772342419405	101	35	0.0206367924528302	1696	10287	23649,81620,4998,5715,6118,5925,5708,5111,5707,5687,890,4174,1027,23595,9837,5983,5558,143471,5695,5682,990,4171,5698,5982,84296,5691,5557,6117,5704,5426,6233,5709,5714,1017,5700	POLA2,CDT1,ORC1,PSMD9,RPA2,RB1,PSMD2,PCNA,PSMD1,PSMA6,CCNA2,MCM5,CDKN1B,ORC3,GINS1,RFC3,PRIM2,PSMA8,PSMB7,PSMA1,CDC6,MCM2,PSMB9,RFC2,GINS4,PSMB3,PRIM1,RPA1,PSMC4,POLE,RPS27A,PSMD3,PSMD8,CDK2,PSMC1
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	7.62479220382139e-06	-11.7841054878	14	10	0.00589622641509434	1696	10287	5347,8615,2801,64689,26003,891,5861,9133,5594,5595	PLK1,USO1,GOLGA2,GORASP1,GORASP2,CCNB1,RAB1A,CCNB2,MAPK1,MAPK3
R-HSA-5688426	Deubiquitination	8.7880519805246e-06	-11.6421174885158	301	79	0.0465801886792453	1696	10287	7874,9804,1540,4287,283899,84196,8678,8027,329,8078,5886,4193,5707,9577,890,5687,23172,51377,5887,9929,57506,9736,330,143471,7417,5695,672,23326,7416,221656,5698,27005,3416,4087,6233,5714,8312,5709,8473,60,8237,4086,409,5700,4089,8975,23586,55593,63967,29086,55252,5715,57599,27430,5708,9738,5728,8313,84282,54764,7040,387,2648,221937,7128,84132,5682,9100,23252,154,55288,5691,5704,9146,9817,6478,10868,114785,7528	USP7,TOMM20,CYLD,ATXN3,INO80E,USP48,BECN1,STAM,BIRC2,USP5,RAD23A,MDM2,PSMD1,BABAM2,CCNA2,PSMA6,ABRAXAS2,UCHL5,RAD23B,JOSD1,MAVS,USP34,BIRC3,PSMA8,VDAC2,PSMB7,BRCA1,USP22,VDAC1,KDM1B,PSMB9,USP21,IDE,SMAD2,RPS27A,PSMD8,AXIN1,PSMD3,OGT,ACTB,USP11,SMAD1,ARRB2,PSMC1,SMAD4,USP13,DDX58,OTUD5,CLSPN,BABAM1,ASXL2,PSMD9,WDR48,MAT2B,PSMD2,CCP110,PTEN,AXIN2,RNF135,ZRANB1,TGFB1,RHOA,KAT2A,FOXK1,TNFAIP3,USP42,PSMA1,USP10,OTUD3,ADRB2,RHOT1,PSMB3,PSMC4,HGS,KEAP1,SIAH2,USP20,MBD6,YY1
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	9.22478940208174e-06	-11.5936161973409	115	38	0.0224056603773585	1696	10287	6209,6187,6181,23480,6138,6135,6745,6147,23478,6184,6139,6185,6143,200916,6731,6159,10952,11224,6132,6169,6128,6204,6746,6229,6157,6203,3921,25873,6167,6161,1650,29927,6233,6208,6176,60559,2197,6231	RPS15,RPS2,RPLP2,SEC61G,RPL15,RPL11,SSR1,RPL23A,SEC11A,RPN1,RPL17,RPN2,RPL19,RPL22L1,SRP72,RPL29,SEC61B,RPL35,RPL8,RPL38,RPL6,RPS10,SSR2,RPS24,RPL27A,RPS9,RPSA,RPL36,RPL37,RPL32,DDOST,SEC61A1,RPS27A,RPS14,RPLP1,SPCS3,FAU,RPS26
R-HSA-68877	Mitotic Prometaphase	9.61972843479697e-06	-11.5516945229162	111	37	0.0218160377358491	1696	10287	22919,1063,55143,1457,83540,11004,11243,891,54908,64151,79003,9126,25909,57122,23047,9735,79019,79902,81929,10051,10726,5347,57551,5905,10592,9212,79682,5515,3796,81930,5525,79980,332,113130,80152,54820,9133	MAPRE1,CENPF,CDCA8,CSNK2A1,NUF2,KIF2C,PMF1,CCNB1,SPDL1,NCAPG,MIS12,SMC3,AHCTF1,NUP107,PDS5B,KNTC1,CENPM,NUP85,SEH1L,SMC4,NUDC,PLK1,TAOK1,RANGAP1,SMC2,AURKB,CENPU,PPP2CA,KIF2A,KIF18A,PPP2R5A,DSN1,BIRC5,CDCA5,CENPT,NDE1,CCNB2
R-HSA-73857	RNA Polymerase II Transcription	1.1038445242791e-05	-11.4141263564901	159	48	0.0283018867924528	1696	10287	9150,51362,84324,9984,5440,6431,9939,6634,79577,10914,2962,8812,25888,9775,6429,9646,6917,10898,26097,2966,1477,84248,9295,5438,5436,5441,6628,6924,5433,10921,7884,23168,55840,6430,10212,8189,5430,6426,55677,11198,6873,54623,5439,6883,6428,6637,6878,6749	CTDP1,CDC40,SARNP,THOC1,POLR2K,SRSF6,RBM8A,SNRPD3,CDC73,PAPOLA,GTF2F1,CCNK,ZNF473,EIF4A3,SRSF4,CTR9,TCEA1,CPSF4,CHTOP,GTF2H2,CSTF1,FYTTD1,SRSF11,POLR2I,POLR2G,POLR2L,SNRPB,ELOA,POLR2D,RNPS1,SLBP,RTF1,EAF2,SRSF5,DDX39A,SYMPK,POLR2A,SRSF1,IWS1,SUPT16H,TAF2,PAF1,POLR2J,TAF12,SRSF3,SNRPG,TAF6,SSRP1
R-HSA-983169	Class I MHC mediated antigen processing & presentation	1.41659855094751e-05	-11.1646668535421	373	93	0.0548349056603774	1696	10287	142678,154881,90933,7325,84231,23304,81559,6890,8454,65264,55585,26263,5707,5687,6477,79876,26190,51434,6891,25897,140459,51132,10952,143471,9978,7428,64320,5695,8452,7335,8697,79754,899,5698,53339,89122,8881,29927,6233,5714,7174,5709,22954,57542,26224,57154,5700,7323,9320,23480,9903,3133,9354,3693,5715,3105,8916,5708,92912,1520,51320,51088,27252,10075,223082,9632,25793,26046,23194,89910,9690,90678,54620,9040,5682,26268,29882,5691,5704,1514,22872,3106,23014,150726,9817,996,8773,84078,6478,9604,11065,29945,55905	MIB2,KCTD7,TRIM41,UBE2E2,TRAF7,UBR2,TRIM11,TAP1,CUL1,UBE2Z,UBE2Q1,FBXO22,PSMD1,PSMA6,SIAH1,UBA5,FBXW2,ANAPC7,TAP2,RNF19A,ASB6,RLIM,SEC61B,PSMA8,RBX1,VHL,RNF25,PSMB7,CUL3,UBE2V1,CDC23,ASB13,CCNF,PSMB9,BTBD1,TRIM4,CDC16,SEC61A1,RPS27A,PSMD8,TPP2,PSMD3,TRIM32,KLHL42,FBXL3,SMURF1,PSMC1,UBE2D3,TRIP12,SEC61G,KLHL21,HLA-E,UBE4A,ITGB5,PSMD9,HLA-A,HERC3,PSMD2,UBE2Q2,CTSS,MEX3C,KLHL5,KLHL20,HUWE1,ZNRF2,SEC24C,FBXO7,LTN1,FBXL7,UBE3B,UBE3C,LRSAM1,FBXL19,UBE2M,PSMA1,FBXO9,ANAPC2,PSMB3,PSMC4,CTSL,SEC31A,HLA-B,FBXO21,FBXO41,KEAP1,CDC27,SNAP23,KBTBD7,SIAH2,RNF14,UBE2C,ANAPC4,RNF114
R-HSA-72312	rRNA processing	1.41964874288557e-05	-11.1625159881217	201	57	0.0336084905660377	1696	10287	6209,51202,6187,4839,6181,6138,88745,56902,6135,6147,11103,27042,23016,25926,6139,51096,51013,6143,2091,84916,55178,200916,387338,29960,54913,6159,118460,11224,54881,57418,6204,6128,84135,6132,6169,6229,5393,9790,57050,6157,54433,6203,3921,25873,27340,6167,6161,6233,6208,10607,6176,2197,22984,6231,1453,705,11056	RPS15,DDX47,RPS2,NOP2,RPLP2,RPL15,RRP36,PNO1,RPL11,RPL23A,KRR1,UTP25,EXOSC7,NOL11,RPL17,UTP18,EXOSC1,RPL19,FBL,UTP4,MRM3,RPL22L1,NSUN4,MRM2,RPP25,RPL29,EXOSC6,RPL35,TEX10,WDR18,RPS10,RPL6,UTP15,RPL8,RPL38,RPS24,EXOSC9,BMS1,UTP3,RPL27A,GAR1,RPS9,RPSA,RPL36,UTP20,RPL37,RPL32,RPS27A,RPS14,TBL3,RPLP1,FAU,PDCD11,RPS26,CSNK1D,BYSL,DDX52
R-HSA-69242	S Phase	1.50245083285882e-05	-11.1058278016333	130	41	0.0241745283018868	1696	10287	23649,4149,81620,8454,4998,5715,6118,5925,5708,5111,5707,9126,5687,890,4174,23047,1027,994,23595,9837,5983,5558,143471,5695,5682,990,4171,5698,5982,5691,84296,5557,6117,5704,5426,6233,5714,5709,113130,1017,5700	POLA2,MAX,CDT1,CUL1,ORC1,PSMD9,RPA2,RB1,PSMD2,PCNA,PSMD1,SMC3,PSMA6,CCNA2,MCM5,PDS5B,CDKN1B,CDC25B,ORC3,GINS1,RFC3,PRIM2,PSMA8,PSMB7,PSMA1,CDC6,MCM2,PSMB9,RFC2,PSMB3,GINS4,PRIM1,RPA1,PSMC4,POLE,RPS27A,PSMD8,PSMD3,CDCA5,CDK2,PSMC1
R-HSA-162587	HIV Life Cycle	1.55782796184466e-05	-11.0696329460547	152	46	0.027122641509434	1696	10287	9150,27243,55706,10015,23511,5440,8480,53371,23165,2962,8812,23225,8815,57122,9972,6917,2966,79902,81929,5438,5441,5436,6924,5433,9631,5905,25978,5430,9397,7520,11198,6873,3836,29082,5439,6233,23636,128866,6883,27183,91782,7518,6878,9818,8086,6749	CTDP1,CHMP2A,NDC1,PDCD6IP,NUP188,POLR2K,RAE1,NUP54,NUP205,GTF2F1,CCNK,NUP210,BANF1,NUP107,NUP153,TCEA1,GTF2H2,NUP85,SEH1L,POLR2I,POLR2L,POLR2G,ELOA,POLR2D,NUP155,RANGAP1,CHMP2B,POLR2A,NMT2,XRCC5,SUPT16H,TAF2,KPNA1,CHMP4A,POLR2J,RPS27A,NUP62,CHMP4B,TAF12,VPS4A,CHMP7,XRCC4,TAF6,NUP58,AAAS,SSRP1
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	1.61067485299606e-05	-11.0362722104467	61	24	0.0141509433962264	1696	10287	10163,23191,4690,10096,7410,5879,4627,7456,4650,10787,26999,10552,5595,7409,7454,998,9844,10092,3984,60,5594,10006,4644,1072	WASF2,CYFIP1,NCK1,ACTR3,VAV2,RAC1,MYH9,WIPF1,MYO9B,NCKAP1,CYFIP2,ARPC1A,MAPK3,VAV1,WAS,CDC42,ELMO1,ARPC5,LIMK1,ACTB,MAPK1,ABI1,MYO5A,CFL1
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	1.61109421104259e-05	-11.0360118826326	179	52	0.0306603773584906	1696	10287	6209,51202,6187,6181,6138,88745,56902,6135,6147,11103,27042,23016,25926,6139,51096,51013,6143,2091,84916,200916,54913,6159,118460,11224,54881,57418,6204,6128,84135,6132,6169,6229,5393,9790,57050,6157,6203,3921,25873,6167,27340,6161,6233,6208,10607,6176,2197,22984,6231,1453,705,11056	RPS15,DDX47,RPS2,RPLP2,RPL15,RRP36,PNO1,RPL11,RPL23A,KRR1,UTP25,EXOSC7,NOL11,RPL17,UTP18,EXOSC1,RPL19,FBL,UTP4,RPL22L1,RPP25,RPL29,EXOSC6,RPL35,TEX10,WDR18,RPS10,RPL6,UTP15,RPL8,RPL38,RPS24,EXOSC9,BMS1,UTP3,RPL27A,RPS9,RPSA,RPL36,RPL37,UTP20,RPL32,RPS27A,RPS14,TBL3,RPLP1,FAU,PDCD11,RPS26,CSNK1D,BYSL,DDX52
R-HSA-176033	Interactions of Vpr with host cellular proteins	1.65909161710966e-05	-11.0066552309892	36	17	0.0100235849056604	1696	10287	55706,23511,8480,53371,9631,292,23165,3836,23225,8815,57122,9972,23636,9818,79902,8086,81929	NDC1,NUP188,RAE1,NUP54,NUP155,SLC25A5,NUP205,KPNA1,NUP210,BANF1,NUP107,NUP153,NUP62,NUP58,NUP85,AAAS,SEH1L
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	1.82854365939082e-05	-10.9094056294859	93	32	0.0188679245283019	1696	10287	5564,112858,5562,22974,116028,1457,641,1432,80010,1020,6118,4193,890,5300,26155,1263,5983,7156,672,9212,5982,11198,6117,6873,6233,28996,6794,6883,11200,6878,1017,6749	PRKAB1,TP53RK,PRKAA1,TPX2,RMI2,CSNK2A1,BLM,MAPK14,RMI1,CDK5,RPA2,MDM2,CCNA2,PIN1,NOC2L,PLK3,RFC3,TOP3A,BRCA1,AURKB,RFC2,SUPT16H,RPA1,TAF2,RPS27A,HIPK2,STK11,TAF12,CHEK2,TAF6,CDK2,SSRP1
R-HSA-69304	Regulation of DNA replication	1.8845531526868e-05	-10.8792347264496	77	28	0.0165094339622642	1696	10287	55388,143471,81620,1871,5695,5682,990,4998,4171,5715,5698,5691,5704,5925,5708,5707,5687,890,6233,5714,4174,5709,1869,1027,23595,1017,1870,5700	MCM10,PSMA8,CDT1,E2F3,PSMB7,PSMA1,CDC6,ORC1,MCM2,PSMD9,PSMB9,PSMB3,PSMC4,RB1,PSMD2,PSMD1,PSMA6,CCNA2,RPS27A,PSMD8,MCM5,PSMD3,E2F1,CDKN1B,ORC3,CDK2,E2F2,PSMC1
R-HSA-180910	Vpr-mediated nuclear import of PICs	1.9395061814532e-05	-10.8504920699399	33	16	0.00943396226415094	1696	10287	55706,23511,8480,53371,9631,23165,3836,23225,8815,57122,9972,23636,9818,79902,8086,81929	NDC1,NUP188,RAE1,NUP54,NUP155,NUP205,KPNA1,NUP210,BANF1,NUP107,NUP153,NUP62,NUP58,NUP85,AAAS,SEH1L
R-HSA-68875	Mitotic Prophase	2.37253514814722e-05	-10.6489663987636	141	43	0.0253537735849057	1696	10287	55706,3015,23511,64689,8480,53371,2029,891,23165,4000,5925,23225,10783,387893,8815,9663,57122,9972,79648,79902,81929,10051,5347,8615,140609,26003,9631,10592,5861,94239,5595,84930,221496,5515,2801,3014,23636,3020,9133,5594,55844,9818,8086	NDC1,H2AFZ,NUP188,GORASP1,RAE1,NUP54,ENSA,CCNB1,NUP205,LMNA,RB1,NUP210,NEK6,KMT5A,BANF1,LPIN2,NUP107,NUP153,MCPH1,NUP85,SEH1L,SMC4,PLK1,USO1,NEK7,GORASP2,NUP155,SMC2,RAB1A,H2AFV,MAPK3,MASTL,LEMD2,PPP2CA,GOLGA2,H2AFX,NUP62,H3F3A,CCNB2,MAPK1,PPP2R2D,NUP58,AAAS
R-HSA-8868773	rRNA processing in the nucleus and cytosol	2.59879997645388e-05	-10.5578756740064	191	54	0.0318396226415094	1696	10287	6209,51202,6187,4839,6181,6138,88745,56902,6135,6147,11103,27042,23016,25926,6139,51096,51013,6143,2091,84916,200916,54913,6159,118460,11224,54881,57418,6204,6128,84135,6132,6169,6229,5393,9790,57050,6157,54433,6203,3921,25873,27340,6167,6161,6233,6208,10607,6176,2197,22984,6231,1453,705,11056	RPS15,DDX47,RPS2,NOP2,RPLP2,RPL15,RRP36,PNO1,RPL11,RPL23A,KRR1,UTP25,EXOSC7,NOL11,RPL17,UTP18,EXOSC1,RPL19,FBL,UTP4,RPL22L1,RPP25,RPL29,EXOSC6,RPL35,TEX10,WDR18,RPS10,RPL6,UTP15,RPL8,RPL38,RPS24,EXOSC9,BMS1,UTP3,RPL27A,GAR1,RPS9,RPSA,RPL36,UTP20,RPL37,RPL32,RPS27A,RPS14,TBL3,RPLP1,FAU,PDCD11,RPS26,CSNK1D,BYSL,DDX52
R-HSA-1852241	Organelle biogenesis and maintenance	2.96635211539756e-05	-10.4255925110393	340	85	0.0501179245283019	1696	10287	11336,11116,5564,261734,64960,8655,54148,1432,5566,9801,54534,23059,4899,4218,64981,23107,6102,80254,1386,64983,10498,78988,1639,5347,10576,2551,6182,84545,51259,4209,11232,63931,378,51069,7818,51668,128308,118487,51264,8648,28998,1453,203068,9371,65005,22919,28977,7978,51116,56652,10540,64949,54930,54205,506,11020,8766,55142,84340,9738,55835,116541,22920,51642,64976,65003,1385,219927,56912,10499,255758,7284,55173,54948,117177,10694,166379,93323,5108,4957,60412,8636,5311,54820,11222	EXOC3,FGFR1OP,PRKAB1,NPHP4,MRPS15,DYNLL1,MRPL39,MAPK14,PRKACA,MRPL19,MRPL50,CLUAP1,NRF1,RAB8A,MRPL34,MRPS27,RP2,CEP63,ATF2,MRPL32,CARM1,MRPL57,DCTN1,PLK1,CCT2,GABPA,MRPL12,MRPL43,TMEM216,MEF2D,POLG2,MRPS14,ARF4,MRPL2,DAP3,HSPB11,MRPL55,CHCHD1,MRPL27,NCOA1,MRPL13,CSNK1D,TUBB,KIF3B,MRPL9,MAPRE1,MRPL42,MTERF1,MRPS2,TWNK,DCTN2,MRPS26,HAUS4,CYCS,ATP5F1B,IFT27,RAB11A,HAUS2,GFM2,CCP110,CENPJ,MRPL54,KIFAP3,MRPL48,MRPL40,MRPL11,CREB1,MRPL21,IFT46,NCOA2,TCTEX1D2,TUFM,MRPS10,MRPL16,RAB3IP,CCT8,BBS12,HAUS8,PCM1,ODF2,EXOC4,SSNA1,PKD2,NDE1,MRPL3
R-HSA-113510	E2F mediated regulation of DNA replication	3.10571459387759e-05	-10.3796816331079	34	16	0.00943396226415094	1696	10287	23649,5558,81620,6241,990,4998,891,5557,26271,5515,5925,5111,7027,1869,23595,7029	POLA2,PRIM2,CDT1,RRM2,CDC6,ORC1,CCNB1,PRIM1,FBXO5,PPP2CA,RB1,PCNA,TFDP1,E2F1,ORC3,TFDP2
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	3.11255095404573e-05	-10.3774828325357	311	79	0.0465801886792453	1696	10287	142678,154881,90933,7325,84231,23304,81559,8454,65264,55585,26263,5707,5687,6477,79876,26190,51434,25897,140459,51132,143471,9978,7428,64320,8452,5695,7335,8697,79754,899,5698,53339,89122,8881,6233,5714,7174,5709,22954,57542,26224,57154,5700,7323,9320,9903,9354,5715,8916,5708,92912,51320,27252,51088,10075,223082,25793,26046,23194,89910,9690,90678,54620,9040,5682,26268,29882,5691,5704,23014,150726,9817,996,84078,6478,9604,11065,29945,55905	MIB2,KCTD7,TRIM41,UBE2E2,TRAF7,UBR2,TRIM11,CUL1,UBE2Z,UBE2Q1,FBXO22,PSMD1,PSMA6,SIAH1,UBA5,FBXW2,ANAPC7,RNF19A,ASB6,RLIM,PSMA8,RBX1,VHL,RNF25,CUL3,PSMB7,UBE2V1,CDC23,ASB13,CCNF,PSMB9,BTBD1,TRIM4,CDC16,RPS27A,PSMD8,TPP2,PSMD3,TRIM32,KLHL42,FBXL3,SMURF1,PSMC1,UBE2D3,TRIP12,KLHL21,UBE4A,PSMD9,HERC3,PSMD2,UBE2Q2,MEX3C,KLHL20,KLHL5,HUWE1,ZNRF2,FBXO7,LTN1,FBXL7,UBE3B,UBE3C,LRSAM1,FBXL19,UBE2M,PSMA1,FBXO9,ANAPC2,PSMB3,PSMC4,FBXO21,FBXO41,KEAP1,CDC27,KBTBD7,SIAH2,RNF14,UBE2C,ANAPC4,RNF114
R-HSA-1632852	Macroautophagy	3.14940470529252e-05	-10.3657120124389	67	25	0.0147405660377358	1696	10287	27243,5564,7249,79065,9821,8655,5562,8649,64121,25978,81631,8678,6009,115201,8897,7248,29082,64422,389541,9776,128866,26100,91782,56270,64223	CHMP2A,PRKAB1,TSC2,ATG9A,RB1CC1,DYNLL1,PRKAA1,LAMTOR3,RRAGC,CHMP2B,MAP1LC3B,BECN1,RHEB,ATG4A,MTMR3,TSC1,CHMP4A,ATG3,LAMTOR4,ATG13,CHMP4B,WIPI2,CHMP7,WDR45B,MLST8
R-HSA-5419276	Mitochondrial translation termination	3.15613379740219e-05	-10.3635776682711	87	30	0.017688679245283	1696	10287	65005,28977,51116,64960,54148,64949,6182,84545,55173,54948,63931,84340,9801,54534,51069,7818,128308,118487,51264,64981,23107,116541,51642,64976,65003,219927,28998,11222,64983,78988	MRPL9,MRPL42,MRPS2,MRPS15,MRPL39,MRPS26,MRPL12,MRPL43,MRPS10,MRPL16,MRPS14,GFM2,MRPL19,MRPL50,MRPL2,DAP3,MRPL55,CHCHD1,MRPL27,MRPL34,MRPS27,MRPL54,MRPL48,MRPL40,MRPL11,MRPL21,MRPL13,MRPL3,MRPL32,MRPL57
R-HSA-6807878	COPI-mediated anterograde transport	3.24920967858019e-05	-10.3345136740221	79	28	0.0165094339622642	1696	10287	51014,8615,11070,1314,64689,8655,288,11316,10540,9382,23423,375,5861,9527,26958,9276,378,966,8774,2801,4905,10972,381,1783,10959,10945,1639,6709	TMED7,USO1,TMEM115,COPA,GORASP1,DYNLL1,ANK3,COPE,DCTN2,COG1,TMED3,ARF1,RAB1A,GOSR1,COPG2,COPB2,ARF4,CD59,NAPG,GOLGA2,NSF,TMED10,ARF5,DYNC1LI2,TMED2,KDELR1,DCTN1,SPTAN1
R-HSA-5663220	RHO GTPases Activate Formins	3.61008409403562e-05	-10.22919439815	117	37	0.0218160377358491	1696	10287	22919,389,5879,1063,55143,83540,11004,11243,54908,79003,25909,998,57122,9735,79019,79902,1856,81929,10726,5347,387,57551,5905,9212,79682,388,5515,3796,81930,5525,79980,332,3688,60,1855,80152,54820	MAPRE1,RHOC,RAC1,CENPF,CDCA8,NUF2,KIF2C,PMF1,SPDL1,MIS12,AHCTF1,CDC42,NUP107,KNTC1,CENPM,NUP85,DVL2,SEH1L,NUDC,PLK1,RHOA,TAOK1,RANGAP1,AURKB,CENPU,RHOB,PPP2CA,KIF2A,KIF18A,PPP2R5A,DSN1,BIRC5,ITGB1,ACTB,DVL1,CENPT,NDE1
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	3.64428826698076e-05	-10.2197643814069	31	15	0.00884433962264151	1696	10287	55706,23511,23225,3836,8480,57122,53371,23636,9972,9631,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,KPNA1,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-162599	Late Phase of HIV Life Cycle	3.74639947623269e-05	-10.1921302258885	139	42	0.0247641509433962	1696	10287	9150,27243,55706,10015,23511,5440,8480,53371,23165,2962,8812,23225,57122,9972,6917,2966,79902,81929,5438,5441,5436,6924,5433,9631,5905,25978,5430,9397,11198,6873,29082,5439,6233,23636,128866,6883,27183,91782,6878,9818,8086,6749	CTDP1,CHMP2A,NDC1,PDCD6IP,NUP188,POLR2K,RAE1,NUP54,NUP205,GTF2F1,CCNK,NUP210,NUP107,NUP153,TCEA1,GTF2H2,NUP85,SEH1L,POLR2I,POLR2L,POLR2G,ELOA,POLR2D,NUP155,RANGAP1,CHMP2B,POLR2A,NMT2,SUPT16H,TAF2,CHMP4A,POLR2J,RPS27A,NUP62,CHMP4B,TAF12,VPS4A,CHMP7,TAF6,NUP58,AAAS,SSRP1
R-HSA-5357801	Programmed Cell Death	3.77999219314719e-05	-10.1832035206458	175	50	0.0294811320754717	1696	10287	118,63967,839,8655,9500,331,54205,598,5715,329,10134,4000,8837,5708,5707,5687,1612,596,7159,6709,578,330,143471,208,5695,5682,5339,5698,26060,5691,8772,1613,5704,355,3836,2339,6233,5714,5709,7027,5534,1869,3148,148022,7534,6093,2620,7029,7533,5700	ADD1,CLSPN,CASP6,DYNLL1,MAGED1,XIAP,CYCS,BCL2L1,PSMD9,BIRC2,BCAP31,LMNA,CFLAR,PSMD2,PSMD1,PSMA6,DAPK1,BCL2,TP53BP2,SPTAN1,BAK1,BIRC3,PSMA8,AKT2,PSMB7,PSMA1,PLEC,PSMB9,APPL1,PSMB3,FADD,DAPK3,PSMC4,FAS,KPNA1,FNTA,RPS27A,PSMD8,PSMD3,TFDP1,PPP3R1,E2F1,HMGB2,TICAM1,YWHAZ,ROCK1,GAS2,TFDP2,YWHAH,PSMC1
R-HSA-5389840	Mitochondrial translation elongation	4.04388298427787e-05	-10.1157200998692	88	30	0.017688679245283	1696	10287	65005,28977,51116,64960,54148,64949,6182,84545,7284,55173,54948,63931,9801,54534,51069,7818,128308,118487,51264,64981,23107,116541,51642,64976,65003,219927,28998,11222,64983,78988	MRPL9,MRPL42,MRPS2,MRPS15,MRPL39,MRPS26,MRPL12,MRPL43,TUFM,MRPS10,MRPL16,MRPS14,MRPL19,MRPL50,MRPL2,DAP3,MRPL55,CHCHD1,MRPL27,MRPL34,MRPS27,MRPL54,MRPL48,MRPL40,MRPL11,MRPL21,MRPL13,MRPL3,MRPL32,MRPL57
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	4.2626362455303e-05	-10.0630376591107	76	27	0.0159198113207547	1696	10287	23586,55706,23511,8480,53371,9631,3661,1982,23165,9636,5595,3840,3836,23225,3716,9775,6233,5300,6772,57122,23636,9972,3838,79902,9818,8086,81929	DDX58,NDC1,NUP188,RAE1,NUP54,NUP155,IRF3,EIF4G2,NUP205,ISG15,MAPK3,KPNA4,KPNA1,NUP210,JAK1,EIF4A3,RPS27A,PIN1,STAT1,NUP107,NUP62,NUP153,KPNA2,NUP85,NUP58,AAAS,SEH1L
R-HSA-1169408	ISG15 antiviral mechanism	4.2626362455303e-05	-10.0630376591107	76	27	0.0159198113207547	1696	10287	23586,55706,23511,8480,53371,9631,3661,1982,23165,9636,5595,3840,3836,23225,3716,9775,6233,5300,6772,57122,23636,9972,3838,79902,9818,8086,81929	DDX58,NDC1,NUP188,RAE1,NUP54,NUP155,IRF3,EIF4G2,NUP205,ISG15,MAPK3,KPNA4,KPNA1,NUP210,JAK1,EIF4A3,RPS27A,PIN1,STAT1,NUP107,NUP62,NUP153,KPNA2,NUP85,NUP58,AAAS,SEH1L
R-HSA-109581	Apoptosis	4.88716400592992e-05	-9.92631328761162	172	49	0.0288915094339623	1696	10287	118,63967,839,8655,9500,331,54205,598,5715,329,10134,4000,8837,5708,5707,5687,1612,596,7159,6709,578,143471,208,5695,5682,5339,5698,26060,5691,8772,1613,5704,355,3836,2339,6233,5714,5709,7027,5534,1869,3148,148022,7534,6093,2620,7029,7533,5700	ADD1,CLSPN,CASP6,DYNLL1,MAGED1,XIAP,CYCS,BCL2L1,PSMD9,BIRC2,BCAP31,LMNA,CFLAR,PSMD2,PSMD1,PSMA6,DAPK1,BCL2,TP53BP2,SPTAN1,BAK1,PSMA8,AKT2,PSMB7,PSMA1,PLEC,PSMB9,APPL1,PSMB3,FADD,DAPK3,PSMC4,FAS,KPNA1,FNTA,RPS27A,PSMD8,PSMD3,TFDP1,PPP3R1,E2F1,HMGB2,TICAM1,YWHAZ,ROCK1,GAS2,TFDP2,YWHAH,PSMC1
R-HSA-68962	Activation of the pre-replicative complex	5.81976178515871e-05	-9.75166613444966	32	15	0.00884433962264151	1696	10287	23649,6118,55388,5426,5558,4174,81620,10926,990,4998,4171,23595,1017,6117,5557	POLA2,RPA2,MCM10,POLE,PRIM2,MCM5,CDT1,DBF4,CDC6,ORC1,MCM2,ORC3,CDK2,RPA1,PRIM1
R-HSA-5368287	Mitochondrial translation	6.25101459291392e-05	-9.68018167953057	94	31	0.0182783018867925	1696	10287	65005,28977,51116,64960,54148,64949,6182,84545,7284,55173,54948,63931,84340,9801,54534,51069,7818,128308,118487,51264,64981,23107,116541,51642,64976,65003,219927,28998,11222,64983,78988	MRPL9,MRPL42,MRPS2,MRPS15,MRPL39,MRPS26,MRPL12,MRPL43,TUFM,MRPS10,MRPL16,MRPS14,GFM2,MRPL19,MRPL50,MRPL2,DAP3,MRPL55,CHCHD1,MRPL27,MRPL34,MRPS27,MRPL54,MRPL48,MRPL40,MRPL11,MRPL21,MRPL13,MRPL3,MRPL32,MRPL57
R-HSA-927802	Nonsense-Mediated Decay (NMD)	6.62944446352275e-05	-9.62140445560702	120	37	0.0218160377358491	1696	10287	6209,6187,6181,23708,9939,6138,6135,6147,9775,6139,55802,6143,26019,200916,26986,6159,11224,10921,6132,6169,6128,6204,6229,6157,6203,3921,25873,6167,5515,5976,6161,6233,6208,6176,56006,2197,6231	RPS15,RPS2,RPLP2,GSPT2,RBM8A,RPL15,RPL11,RPL23A,EIF4A3,RPL17,DCP1A,RPL19,UPF2,RPL22L1,PABPC1,RPL29,RPL35,RNPS1,RPL8,RPL38,RPL6,RPS10,RPS24,RPL27A,RPS9,RPSA,RPL36,RPL37,PPP2CA,UPF1,RPL32,RPS27A,RPS14,RPLP1,SMG9,FAU,RPS26
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	6.62944446352275e-05	-9.62140445560702	120	37	0.0218160377358491	1696	10287	6209,6187,6181,23708,9939,6138,6135,6147,9775,6139,55802,6143,26019,200916,26986,6159,11224,10921,6132,6169,6128,6204,6229,6157,6203,3921,25873,6167,5515,5976,6161,6233,6208,6176,56006,2197,6231	RPS15,RPS2,RPLP2,GSPT2,RBM8A,RPL15,RPL11,RPL23A,EIF4A3,RPL17,DCP1A,RPL19,UPF2,RPL22L1,PABPC1,RPL29,RPL35,RNPS1,RPL8,RPL38,RPL6,RPS10,RPS24,RPL27A,RPS9,RPSA,RPL36,RPL37,PPP2CA,UPF1,RPL32,RPS27A,RPS14,RPLP1,SMG9,FAU,RPS26
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	6.77742622144149e-05	-9.59932804844603	86	29	0.0170990566037736	1696	10287	10163,23191,4690,10096,7410,5879,4627,7456,4650,10787,26999,10552,4067,84513,5595,7409,23646,7454,998,10092,9844,3984,5296,60,10768,5594,10006,1072,4644	WASF2,CYFIP1,NCK1,ACTR3,VAV2,RAC1,MYH9,WIPF1,MYO9B,NCKAP1,CYFIP2,ARPC1A,LYN,PLPP5,MAPK3,VAV1,PLD3,WAS,CDC42,ARPC5,ELMO1,LIMK1,PIK3R2,ACTB,AHCYL1,MAPK1,ABI1,CFL1,MYO5A
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	7.02607923761004e-05	-9.56329663342047	103	33	0.0194575471698113	1696	10287	22919,1063,55143,83540,11004,11243,891,54908,79003,9126,25909,57122,23047,9735,79019,79902,81929,10726,5347,57551,5905,9212,79682,5515,3796,81930,79980,5525,332,113130,80152,54820,9133	MAPRE1,CENPF,CDCA8,NUF2,KIF2C,PMF1,CCNB1,SPDL1,MIS12,SMC3,AHCTF1,NUP107,PDS5B,KNTC1,CENPM,NUP85,SEH1L,NUDC,PLK1,TAOK1,RANGAP1,AURKB,CENPU,PPP2CA,KIF2A,KIF18A,DSN1,PPP2R5A,BIRC5,CDCA5,CENPT,NDE1,CCNB2
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	7.40392561656223e-05	-9.51091511669488	36	16	0.00943396226415094	1696	10287	9761,5589,11253,51035,7841,84447,55741,7844,79139,6233,5887,6400,55768,11236,5700,6048	MLEC,PRKCSH,MAN1B1,UBXN1,MOGS,SYVN1,EDEM2,RNF103,DERL1,RPS27A,RAD23B,SEL1L,NGLY1,RNF139,PSMC1,RNF5
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	7.40392561656223e-05	-9.51091511669488	36	16	0.00943396226415094	1696	10287	10163,23191,7454,998,4690,10092,10096,5879,7456,60,10787,26999,10552,5594,10006,5595	WASF2,CYFIP1,WAS,CDC42,NCK1,ARPC5,ACTR3,RAC1,WIPF1,ACTB,NCKAP1,CYFIP2,ARPC1A,MAPK1,ABI1,MAPK3
R-HSA-195258	RHO GTPase Effectors	7.57606932920664e-05	-9.48793095796588	294	74	0.0436320754716981	1696	10287	10163,391,3015,10096,5879,4627,83540,11004,3895,79003,805,25909,998,9928,57122,1027,10006,1856,81929,5347,4690,57120,57551,7456,9212,94239,79682,3796,5515,7454,5525,79980,3984,3688,3014,60,6093,1855,3020,5594,103910,22919,4659,389,1063,55143,3831,10787,11243,54908,6242,3799,10092,9055,9735,79019,79902,10499,10726,5170,23191,387,5905,26999,4221,10552,388,5595,81930,332,7534,80152,54820,7533	WASF2,RHOG,H2AFZ,ACTR3,RAC1,MYH9,NUF2,KIF2C,KTN1,MIS12,CALM2,AHCTF1,CDC42,KIF14,NUP107,CDKN1B,ABI1,DVL2,SEH1L,PLK1,NCK1,GOPC,TAOK1,WIPF1,AURKB,H2AFV,CENPU,KIF2A,PPP2CA,WAS,PPP2R5A,DSN1,LIMK1,ITGB1,H2AFX,ACTB,ROCK1,DVL1,H3F3A,MAPK1,MYL12B,MAPRE1,PPP1R12A,RHOC,CENPF,CDCA8,KLC1,NCKAP1,PMF1,SPDL1,RTKN,KIF5B,ARPC5,PRC1,KNTC1,CENPM,NUP85,NCOA2,NUDC,PDPK1,CYFIP1,RHOA,RANGAP1,CYFIP2,MEN1,ARPC1A,RHOB,MAPK3,KIF18A,BIRC5,YWHAZ,CENPT,NDE1,YWHAH
R-HSA-6799198	Complex I biogenesis	8.53835345872467e-05	-9.36835727918674	51	20	0.0117924528301887	1696	10287	4698,4729,4719,4712,51300,91942,55863,4701,4707,374291,4724,137682,4723,4695,4710,126328,4715,4728,4725,4696	NDUFA5,NDUFV2,NDUFS1,NDUFB6,TIMMDC1,NDUFAF2,TMEM126B,NDUFA7,NDUFB1,NDUFS7,NDUFS4,NDUFAF6,NDUFV1,NDUFA2,NDUFB4,NDUFA11,NDUFB9,NDUFS8,NDUFS5,NDUFA3
R-HSA-453276	Regulation of mitotic cell cycle	8.58807243355077e-05	-9.3625511507146	87	29	0.0170990566037736	1696	10287	5347,143471,9232,5695,5682,8454,29882,9212,8697,891,5715,5698,5691,5704,26271,5708,5687,890,8881,5707,996,6233,5714,5709,51434,1017,11065,5700,29945	PLK1,PSMA8,PTTG1,PSMB7,PSMA1,CUL1,ANAPC2,AURKB,CDC23,CCNB1,PSMD9,PSMB9,PSMB3,PSMC4,FBXO5,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,CDK2,UBE2C,PSMC1,ANAPC4
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	8.58807243355077e-05	-9.3625511507146	87	29	0.0170990566037736	1696	10287	5347,143471,9232,5695,5682,8454,29882,9212,8697,891,5715,5698,5691,5704,26271,5708,5687,890,8881,5707,996,6233,5714,5709,51434,1017,11065,5700,29945	PLK1,PSMA8,PTTG1,PSMB7,PSMA1,CUL1,ANAPC2,AURKB,CDC23,CCNB1,PSMD9,PSMB9,PSMB3,PSMC4,FBXO5,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,CDK2,UBE2C,PSMC1,ANAPC4
R-HSA-5368286	Mitochondrial translation initiation	8.58807243355077e-05	-9.3625511507146	87	29	0.0170990566037736	1696	10287	65005,28977,51116,64960,54148,64949,6182,84545,55173,54948,63931,9801,54534,51069,7818,128308,118487,51264,64981,23107,116541,51642,64976,65003,219927,28998,11222,64983,78988	MRPL9,MRPL42,MRPS2,MRPS15,MRPL39,MRPS26,MRPL12,MRPL43,MRPS10,MRPL16,MRPS14,MRPL19,MRPL50,MRPL2,DAP3,MRPL55,CHCHD1,MRPL27,MRPL34,MRPS27,MRPL54,MRPL48,MRPL40,MRPL11,MRPL21,MRPL13,MRPL3,MRPL32,MRPL57
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	8.67926432618029e-05	-9.35198869493824	117	36	0.0212264150943396	1696	10287	6209,6187,6181,8664,6138,6135,6147,8894,6139,6143,200916,26986,51386,6159,11224,6169,6128,6204,6132,6229,6157,7458,8666,6203,8667,8661,3921,25873,27335,6167,6161,6233,6208,6176,2197,6231	RPS15,RPS2,RPLP2,EIF3D,RPL15,RPL11,RPL23A,EIF2S2,RPL17,RPL19,RPL22L1,PABPC1,EIF3L,RPL29,RPL35,RPL38,RPL6,RPS10,RPL8,RPS24,RPL27A,EIF4H,EIF3G,RPS9,EIF3H,EIF3A,RPSA,RPL36,EIF3K,RPL37,RPL32,RPS27A,RPS14,RPLP1,FAU,RPS26
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	8.67926432618029e-05	-9.35198869493824	117	36	0.0212264150943396	1696	10287	6209,6187,6181,8664,6138,6135,6147,8894,6139,6143,1983,200916,51386,6159,11224,6169,6128,6204,6132,6229,6157,7458,8666,6203,8667,8661,3921,25873,27335,6167,6161,6233,6208,6176,2197,6231	RPS15,RPS2,RPLP2,EIF3D,RPL15,RPL11,RPL23A,EIF2S2,RPL17,RPL19,EIF5,RPL22L1,EIF3L,RPL29,RPL35,RPL38,RPL6,RPS10,RPL8,RPS24,RPL27A,EIF4H,EIF3G,RPS9,EIF3H,EIF3A,RPSA,RPL36,EIF3K,RPL37,RPL32,RPS27A,RPS14,RPLP1,FAU,RPS26
R-HSA-5663202	Diseases of signal transduction	8.92663747390242e-05	-9.32388568366792	370	89	0.0524764150943396	1696	10287	142678,892,11116,7249,4763,102,5894,8454,27044,7409,5906,4193,5707,5687,6464,5296,1185,1027,26127,11140,64223,4893,5441,5436,143471,51107,9978,208,5695,5433,4041,5698,5515,4087,5525,6233,5714,5709,8312,399687,6400,6772,409,5594,5700,4089,3066,9612,57085,5440,22906,8315,84335,5715,83464,1452,2309,8323,4000,2962,2280,5708,2261,51564,5781,1385,9794,6774,7040,5170,6868,5438,55109,2648,5682,3845,84447,8087,23499,5605,5430,5691,5595,5704,5439,1445,3516,3265,56829	MIB2,CCNC,FGFR1OP,TSC2,NF1,ADAM10,RAF1,CUL1,SND1,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,CLCN6,CDKN1B,FGFR1OP2,CDC37,MLST8,NRAS,POLR2L,POLR2G,PSMA8,APH1A,RBX1,AKT2,PSMB7,POLR2D,LRP5,PSMB9,PPP2CA,SMAD2,PPP2R5A,RPS27A,PSMD8,PSMD3,AXIN1,MYO18A,SEL1L,STAT1,ARRB2,MAPK1,PSMC1,SMAD4,HDAC2,NCOR2,AGTRAP,POLR2K,TRAK1,BRAP,AKT1S1,PSMD9,APH1B,CSNK1A1,FOXO3,FZD6,LMNA,GTF2F1,FKBP1A,PSMD2,FGFR3,HDAC7,PTPN11,CREB1,MAML1,STAT3,TGFB1,PDPK1,ADAM17,POLR2I,AGGF1,KAT2A,PSMA1,KRAS,SYVN1,FXR1,MACF1,MAP2K2,POLR2A,PSMB3,MAPK3,PSMC4,POLR2J,CSK,RBPJ,HRAS,ZC3HAV1
R-HSA-72306	tRNA processing	0.000100028271709613	-9.210057694837	109	34	0.0200471698113208	1696	10287	348180,55706,112858,23511,8480,51605,8270,53371,79074,23165,84705,23225,55687,10248,57122,51493,54920,9972,10898,79902,81929,4234,54913,54888,55253,9631,2058,10785,129450,24140,23636,116461,9818,8086	CTU2,NDC1,TP53RK,NUP188,RAE1,TRMT6,LAGE3,NUP54,C2orf49,NUP205,GTPBP3,NUP210,TRMU,POP7,NUP107,RTCB,DUS2,NUP153,CPSF4,NUP85,SEH1L,METTL1,RPP25,NSUN2,TYW1,NUP155,EPRS,WDR4,TYW5,FTSJ1,NUP62,TSEN15,NUP58,AAAS
R-HSA-72689	Formation of a pool of free 40S subunits	0.000106988942859462	-9.14278506660412	105	33	0.0194575471698113	1696	10287	6209,6187,6181,8664,6138,6135,6147,6139,6143,200916,51386,6159,11224,6169,6128,6204,6132,6229,6157,8666,6203,8661,8667,3921,25873,6167,27335,6161,6233,6208,6176,2197,6231	RPS15,RPS2,RPLP2,EIF3D,RPL15,RPL11,RPL23A,RPL17,RPL19,RPL22L1,EIF3L,RPL29,RPL35,RPL38,RPL6,RPS10,RPL8,RPS24,RPL27A,EIF3G,RPS9,EIF3A,EIF3H,RPSA,RPL36,RPL37,EIF3K,RPL32,RPS27A,RPS14,RPLP1,FAU,RPS26
R-HSA-381038	XBP1(S) activates chaperone genes	0.000122466031295941	-9.00767686197635	56	21	0.0123820754716981	1696	10287	10952,118,23480,30827,84447,27230,4000,4189,6745,10897,22872,6464,29927,9797,439,56005,10130,10106,9114,10113,1639	SEC61B,ADD1,SEC61G,CXXC1,SYVN1,SERP1,LMNA,DNAJB9,SSR1,YIF1A,SEC31A,SHC1,SEC61A1,TATDN2,ASNA1,MYDGF,PDIA6,CTDSP2,ATP6V0D1,PREB,DCTN1
R-HSA-4839726	Chromatin organization	0.000130340778012751	-8.94535816797589	279	70	0.0412735849056604	1696	10287	55870,1788,3015,9682,55904,196528,23512,6597,54904,10629,64769,79595,22992,84787,27154,9112,27097,1386,6605,79685,5926,10498,8819,51780,11143,79813,84864,26610,55578,55193,23326,58508,221656,94239,53615,84444,25855,54014,1107,3014,8473,60,8648,3066,9612,6187,23210,9913,11091,57492,79723,23587,387893,54934,10499,2648,9219,23186,8289,55818,51562,2874,84193,54496,9757,10856,6883,5928,112869,6602	ASH1L,DNMT3A,H2AFZ,KDM4A,KMT2E,ARID2,SUZ12,SMARCA4,NSD3,TAF6L,MEAF6,SAP130,KDM2A,KMT5C,BRPF3,MTA1,TAF5L,ATF2,SMARCE1,SAP30L,ARID4A,CARM1,SAP30,KDM3B,KAT7,EHMT1,RIOX2,ELP4,SUPT20H,PBRM1,USP22,KMT2C,KDM1B,H2AFV,MBD3,DOT1L,BRMS1,BRWD1,CHD3,H2AFX,OGT,ACTB,NCOA1,HDAC2,NCOR2,RPS2,JMJD6,SUPT7L,WDR5,ARID1B,SUV39H2,ELP5,KMT5A,KANSL2,NCOA2,KAT2A,MTA2,RCOR1,ARID1A,KDM3A,MBIP,GPS2,SETD3,PRMT7,KMT2B,RUVBL2,TAF12,RBBP4,SGF29,SMARCD1
R-HSA-3247509	Chromatin modifying enzymes	0.000130340778012751	-8.94535816797589	279	70	0.0412735849056604	1696	10287	55870,1788,3015,9682,55904,196528,23512,6597,54904,10629,64769,79595,22992,84787,27154,9112,27097,1386,6605,79685,5926,10498,8819,51780,11143,79813,84864,26610,55578,55193,23326,58508,221656,94239,53615,84444,25855,54014,1107,3014,8473,60,8648,3066,9612,6187,23210,9913,11091,57492,79723,23587,387893,54934,10499,2648,9219,23186,8289,55818,51562,2874,84193,54496,9757,10856,6883,5928,112869,6602	ASH1L,DNMT3A,H2AFZ,KDM4A,KMT2E,ARID2,SUZ12,SMARCA4,NSD3,TAF6L,MEAF6,SAP130,KDM2A,KMT5C,BRPF3,MTA1,TAF5L,ATF2,SMARCE1,SAP30L,ARID4A,CARM1,SAP30,KDM3B,KAT7,EHMT1,RIOX2,ELP4,SUPT20H,PBRM1,USP22,KMT2C,KDM1B,H2AFV,MBD3,DOT1L,BRMS1,BRWD1,CHD3,H2AFX,OGT,ACTB,NCOA1,HDAC2,NCOR2,RPS2,JMJD6,SUPT7L,WDR5,ARID1B,SUV39H2,ELP5,KMT5A,KANSL2,NCOA2,KAT2A,MTA2,RCOR1,ARID1A,KDM3A,MBIP,GPS2,SETD3,PRMT7,KMT2B,RUVBL2,TAF12,RBBP4,SGF29,SMARCD1
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.000137487766960819	-8.89197561237318	34	15	0.00884433962264151	1696	10287	55706,23511,23225,8480,57122,53371,23636,9972,9631,5905,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,RANGAP1,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.000148859091948181	-8.81251039109021	81	27	0.0159198113207547	1696	10287	5347,143471,5695,5682,8454,29882,8697,891,5715,5698,5691,5704,26271,5708,5687,890,8881,5707,996,6233,5714,5709,51434,1017,11065,5700,29945	PLK1,PSMA8,PSMB7,PSMA1,CUL1,ANAPC2,CDC23,CCNB1,PSMD9,PSMB9,PSMB3,PSMC4,FBXO5,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,CDK2,UBE2C,PSMC1,ANAPC4
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.000152437388000381	-8.78875661671325	49	19	0.0112028301886792	1696	10287	1263,7832,891,55571,4849,9125,890,5111,5933,55835,1874,7027,1869,1027,57472,246175,7029,1017,10498	PLK3,BTG2,CCNB1,CNOT11,CNOT3,CNOT9,CCNA2,PCNA,RBL1,CENPJ,E2F4,TFDP1,E2F1,CDKN1B,CNOT6,CNOT6L,TFDP2,CDK2,CARM1
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.000169092445110341	-8.68506498011077	31	14	0.00825471698113208	1696	10287	55706,23511,23225,8480,57122,53371,23636,9972,9631,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.000169092445110341	-8.68506498011077	31	14	0.00825471698113208	1696	10287	55706,23511,23225,8480,57122,53371,23636,9631,9972,79902,9818,8086,23165,81929	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP155,NUP153,NUP85,NUP58,AAAS,NUP205,SEH1L
R-HSA-72737	Cap-dependent Translation Initiation	0.000169920635406112	-8.68017908047494	125	37	0.0218160377358491	1696	10287	6209,6187,6181,8664,6138,6135,6147,8894,6139,6143,1983,200916,26986,51386,6159,11224,6132,6169,6128,6204,6229,6157,7458,8666,6203,8667,8661,3921,25873,27335,6167,6161,6233,6208,6176,2197,6231	RPS15,RPS2,RPLP2,EIF3D,RPL15,RPL11,RPL23A,EIF2S2,RPL17,RPL19,EIF5,RPL22L1,PABPC1,EIF3L,RPL29,RPL35,RPL8,RPL38,RPL6,RPS10,RPS24,RPL27A,EIF4H,EIF3G,RPS9,EIF3H,EIF3A,RPSA,RPL36,EIF3K,RPL37,RPL32,RPS27A,RPS14,RPLP1,FAU,RPS26
R-HSA-72613	Eukaryotic Translation Initiation	0.000169920635406112	-8.68017908047494	125	37	0.0218160377358491	1696	10287	6209,6187,6181,8664,6138,6135,6147,8894,6139,6143,1983,200916,26986,51386,6159,11224,6132,6169,6128,6204,6229,6157,7458,8666,6203,8667,8661,3921,25873,27335,6167,6161,6233,6208,6176,2197,6231	RPS15,RPS2,RPLP2,EIF3D,RPL15,RPL11,RPL23A,EIF2S2,RPL17,RPL19,EIF5,RPL22L1,PABPC1,EIF3L,RPL29,RPL35,RPL8,RPL38,RPL6,RPS10,RPS24,RPL27A,EIF4H,EIF3G,RPS9,EIF3H,EIF3A,RPSA,RPL36,EIF3K,RPL37,RPL32,RPS27A,RPS14,RPLP1,FAU,RPS26
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.000187596817985551	-8.58121548323349	82	27	0.0159198113207547	1696	10287	1329,5564,7295,7249,208,5562,27161,8649,64121,4697,1327,54205,6009,5052,7248,57103,5728,25824,389541,9167,10128,1351,9377,7534,2821,7533,64223	COX5B,PRKAB1,TXN,TSC2,AKT2,PRKAA1,AGO2,LAMTOR3,RRAGC,NDUFA4,COX4I1,CYCS,RHEB,PRDX1,TSC1,TIGAR,PTEN,PRDX5,LAMTOR4,COX7A2L,LRPPRC,COX8A,COX5A,YWHAZ,GPI,YWHAH,MLST8
R-HSA-69300	Removal of licensing factors from origins	0.000203723179594527	-8.4987484483997	74	25	0.0147405660377358	1696	10287	55388,143471,81620,5695,5682,990,4998,4171,5715,5698,5691,5704,5925,5708,5687,890,5707,6233,5714,5709,4174,1027,23595,1017,5700	MCM10,PSMA8,CDT1,PSMB7,PSMA1,CDC6,ORC1,MCM2,PSMD9,PSMB9,PSMB3,PSMC4,RB1,PSMD2,PSMA6,CCNA2,PSMD1,RPS27A,PSMD8,PSMD3,MCM5,CDKN1B,ORC3,CDK2,PSMC1
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.00020422359672722	-8.49629510196955	35	15	0.00884433962264151	1696	10287	55706,23511,23225,8480,57122,53371,7884,23636,9631,9972,79902,9818,8086,23165,81929	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,SLBP,NUP62,NUP155,NUP153,NUP85,NUP58,AAAS,NUP205,SEH1L
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.000210133599231396	-8.46776704271168	70	24	0.0141509433962264	1696	10287	27000,10808,55706,23511,6767,8480,53371,9631,3337,23165,3304,5595,6117,6118,23225,3308,57122,23636,9972,5594,79902,9818,8086,81929	DNAJC2,HSPH1,NDC1,NUP188,ST13,RAE1,NUP54,NUP155,DNAJB1,NUP205,HSPA1B,MAPK3,RPA1,RPA2,NUP210,HSPA4,NUP107,NUP62,NUP153,MAPK1,NUP85,NUP58,AAAS,SEH1L
R-HSA-381070	IRE1alpha activates chaperones	0.00021783333527852	-8.43178030463841	58	21	0.0123820754716981	1696	10287	10952,118,23480,30827,84447,27230,4000,4189,6745,10897,22872,6464,29927,9797,439,56005,10130,10106,9114,10113,1639	SEC61B,ADD1,SEC61G,CXXC1,SYVN1,SERP1,LMNA,DNAJB9,SSR1,YIF1A,SEC31A,SHC1,SEC61A1,TATDN2,ASNA1,MYDGF,PDIA6,CTDSP2,ATP6V0D1,PREB,DCTN1
R-HSA-1538133	G0 and Early G1	0.000244251242903529	-8.31731317840119	25	12	0.00707547169811321	1696	10287	286826,5111,890,5933,1874,7027,1869,4605,990,7029,5928,1017	LIN9,PCNA,CCNA2,RBL1,E2F4,TFDP1,E2F1,MYBL2,CDC6,TFDP2,RBBP4,CDK2
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.000255343977426244	-8.27289899071272	32	14	0.00825471698113208	1696	10287	55706,23511,23225,8480,57122,53371,23636,9972,9631,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-2559585	Oncogene Induced Senescence	0.000255343977426244	-8.27289899071272	32	14	0.00825471698113208	1696	10287	1031,4193,2114,2077,6233,7027,1869,1871,7029,1870,5594,2113,1029,5595	CDKN2C,MDM2,ETS2,ERF,RPS27A,TFDP1,E2F1,E2F3,TFDP2,E2F2,MAPK1,ETS1,CDKN2A,MAPK3
R-HSA-73856	RNA Polymerase II Transcription Termination	0.000268534499264015	-8.22253116339033	71	24	0.0141509433962264	1696	10287	9295,84248,51362,84324,9984,6628,6431,9939,10921,7884,6430,6634,10212,8189,6426,10914,25888,9775,6429,6637,6428,26097,10898,1477	SRSF11,FYTTD1,CDC40,SARNP,THOC1,SNRPB,SRSF6,RBM8A,RNPS1,SLBP,SRSF5,SNRPD3,DDX39A,SYMPK,SRSF1,PAPOLA,ZNF473,EIF4A3,SRSF4,SNRPG,SRSF3,CHTOP,CPSF4,CSTF1
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	0.000268534499264015	-8.22253116339033	71	24	0.0141509433962264	1696	10287	9295,84248,51362,84324,9984,6628,6431,9939,10921,7884,6430,6634,10212,8189,6426,10914,25888,9775,6429,6637,6428,26097,10898,1477	SRSF11,FYTTD1,CDC40,SARNP,THOC1,SNRPB,SRSF6,RBM8A,RNPS1,SLBP,SRSF5,SNRPD3,DDX39A,SYMPK,SRSF1,PAPOLA,ZNF473,EIF4A3,SRSF4,SNRPG,SRSF3,CHTOP,CPSF4,CSTF1
R-HSA-212436	Generic Transcription Pathway	0.000289705097309314	-8.14664705821323	865	180	0.106132075471698	1696	10287	6096,892,84838,7295,7249,4839,1457,891,7329,1432,55215,79943,1020,5111,7752,26155,6917,10498,64223,1263,84527,208,79813,6924,9212,672,5982,6009,4087,1107,6233,115509,1874,25824,9377,6794,10795,11200,7029,7596,7627,3066,6749,163050,124411,7323,1329,84626,5440,5562,8649,4697,1327,8621,54205,4853,7633,55571,133746,4849,57103,112950,84246,155061,4436,9794,7743,5438,9219,79837,4605,388561,355,6257,7248,27153,5439,9167,389541,51586,146198,7534,57472,2821,7528,5928,1017,29959,1029,7874,5564,112858,5395,116028,22974,55659,64121,10308,64769,7626,4193,147923,25888,890,55900,27154,7586,5300,1027,7769,7159,1386,54989,51755,147949,5983,5441,5436,26048,7832,5433,53615,10155,11198,6873,5515,8427,57693,90592,5933,28996,80818,8648,4089,5892,9150,136051,9612,353274,839,27161,641,80010,5305,168374,2962,8812,6118,5728,55835,387893,29117,10370,374655,246175,2966,10499,5170,2648,7753,7156,117584,4221,5430,5052,6117,9125,7733,29028,332,7027,5371,10128,1351,1869,124446,6883,3516,6878,7533	RORB,CCNC,ZNF496,TXN,TSC2,NOP2,CSNK2A1,CCNB1,UBE2I,MAPK14,FANCI,ZNF696,CDK5,PCNA,ZNF200,NOC2L,TCEA1,CARM1,MLST8,PLK3,ZNF559,AKT2,EHMT1,ELOA,AURKB,BRCA1,RFC2,RHEB,SMAD2,CHD3,RPS27A,ZNF689,E2F4,PRDX5,COX5A,STK11,ZNF268,CHEK2,TFDP2,ZNF45,ZNF75A,HDAC2,SSRP1,ZNF564,ZNF720,UBE2D3,COX5B,KRBA1,POLR2K,PRKAA1,LAMTOR3,NDUFA4,COX4I1,CDK13,CYCS,NOTCH2,ZNF79,CNOT11,JMY,CNOT3,TIGAR,MED8,MED10,ZNF746,MSH2,MAML1,ZNF189,POLR2I,MTA2,PIP4K2C,MYBL2,ZNF761,FAS,RXRB,TSC1,ZNF777,POLR2J,COX7A2L,LAMTOR4,MED15,ZFP90,YWHAZ,CNOT6,GPI,YY1,RBBP4,CDK2,NRBP1,CDKN2A,USP7,PRKAB1,TP53RK,PMS2,RMI2,TPX2,ZNF416,RRAGC,ZNF267,MEAF6,ZNF75D,MDM2,ZNF420,ZNF473,CCNA2,ZNF302,BRPF3,ZKSCAN1,PIN1,CDKN1B,ZNF226,TP53BP2,ATF2,ZNF770,CDK12,ZNF583,RFC3,POLR2L,POLR2G,ZNF500,BTG2,POLR2D,MBD3,TRIM28,SUPT16H,TAF2,PPP2CA,ZNF282,ZNF317,ZNF700,RBL1,HIPK2,ZNF436,NCOA1,SMAD4,RAD51D,CTDP1,ZNF786,NCOR2,ZNF445,CASP6,AGO2,BLM,RMI1,PIP4K2A,ZNF92,GTF2F1,CCNK,RPA2,PTEN,CENPJ,KMT5A,BRD7,CITED2,ZNF710,CNOT6L,GTF2H2,NCOA2,PDPK1,KAT2A,ZNF202,TOP3A,RFFL,MEN1,POLR2A,PRDX1,RPA1,CNOT9,ZNF180,ATAD2,BIRC5,TFDP1,PML,LRPPRC,COX8A,E2F1,TMEM219,TAF12,RBPJ,TAF6,YWHAH
R-HSA-177243	Interactions of Rev with host cellular proteins	0.000297212411411534	-8.1210634848502	36	15	0.00884433962264151	1696	10287	55706,23511,23225,8480,57122,53371,23636,9972,9631,5905,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,RANGAP1,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.000315938895387045	-8.0599617321039	13	8	0.00471698113207547	1696	10287	23649,5515,5925,7029,5558,7027,5557,1869	POLA2,PPP2CA,RB1,TFDP2,PRIM2,TFDP1,PRIM1,E2F1
R-HSA-3371556	Cellular response to heat stress	0.000340120385685047	-7.98621092747976	89	28	0.0165094339622642	1696	10287	27000,10808,55706,23511,6767,8480,53371,9631,84335,3337,23165,3304,5595,6117,6118,23225,3308,57122,23636,9972,10728,5594,79902,9818,8086,818,81929,64223	DNAJC2,HSPH1,NDC1,NUP188,ST13,RAE1,NUP54,NUP155,AKT1S1,DNAJB1,NUP205,HSPA1B,MAPK3,RPA1,RPA2,NUP210,HSPA4,NUP107,NUP62,NUP153,PTGES3,MAPK1,NUP85,NUP58,AAAS,CAMK2G,SEH1L,MLST8
R-HSA-68949	Orc1 removal from chromatin	0.000340781031623246	-7.98427042294059	72	24	0.0141509433962264	1696	10287	143471,81620,5695,5682,990,4998,4171,5715,5698,5691,5704,5708,5925,5687,890,5707,6233,5714,5709,4174,1027,23595,1017,5700	PSMA8,CDT1,PSMB7,PSMA1,CDC6,ORC1,MCM2,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,RB1,PSMA6,CCNA2,PSMD1,RPS27A,PSMD8,PSMD3,MCM5,CDKN1B,ORC3,CDK2,PSMC1
R-HSA-69052	Switching of origins to a post-replicative state	0.000340781031623246	-7.98427042294059	72	24	0.0141509433962264	1696	10287	143471,81620,5695,5682,990,4998,4171,5715,5698,5691,5704,5708,5925,5687,890,5707,6233,5714,5709,4174,1027,23595,1017,5700	PSMA8,CDT1,PSMB7,PSMA1,CDC6,ORC1,MCM2,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,RB1,PSMA6,CCNA2,PSMD1,RPS27A,PSMD8,PSMD3,MCM5,CDKN1B,ORC3,CDK2,PSMC1
R-HSA-4570464	SUMOylation of RNA binding proteins	0.0003680417397515	-7.9073142029895	48	18	0.0106132075471698	1696	10287	55706,23511,8480,6613,53371,9631,7329,23165,1912,23225,57122,9972,23636,79902,9818,8535,81929,8086	NDC1,NUP188,RAE1,SUMO2,NUP54,NUP155,UBE2I,NUP205,PHC2,NUP210,NUP107,NUP153,NUP62,NUP85,NUP58,CBX4,SEH1L,AAAS
R-HSA-180746	Nuclear import of Rev protein	0.000376783585166647	-7.88383957999378	33	14	0.00825471698113208	1696	10287	55706,23511,23225,8480,57122,53371,23636,9972,9631,79902,9818,81929,8086,23165	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP153,NUP155,NUP85,NUP58,SEH1L,AAAS,NUP205
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.000408014738374199	-7.80420726074638	77	25	0.0147405660377358	1696	10287	5347,143471,9232,5695,5682,29882,8697,891,5715,5698,5691,5704,5708,5687,890,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PLK1,PSMA8,PTTG1,PSMB7,PSMA1,ANAPC2,CDC23,CCNB1,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-69620	Cell Cycle Checkpoints	0.000422761335900272	-7.76870275587857	201	52	0.0306603773584906	1696	10287	55388,63967,29086,10926,116028,4998,641,891,5715,80010,6118,5708,4193,5707,9577,5687,890,4174,51512,1027,51434,23595,5983,143471,7156,5695,5682,29882,990,672,9088,8697,4171,5698,5982,5691,5704,6117,8881,996,6233,5714,5709,3014,7534,11200,1017,11065,7533,9133,5700,29945	MCM10,CLSPN,BABAM1,DBF4,RMI2,ORC1,BLM,CCNB1,PSMD9,RMI1,RPA2,PSMD2,MDM2,PSMD1,BABAM2,PSMA6,CCNA2,MCM5,GTSE1,CDKN1B,ANAPC7,ORC3,RFC3,PSMA8,TOP3A,PSMB7,PSMA1,ANAPC2,CDC6,BRCA1,PKMYT1,CDC23,MCM2,PSMB9,RFC2,PSMB3,PSMC4,RPA1,CDC16,CDC27,RPS27A,PSMD8,PSMD3,H2AFX,YWHAZ,CHEK2,CDK2,UBE2C,YWHAH,CCNB2,PSMC1,ANAPC4
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.000429563140911671	-7.75274181707327	73	24	0.0141509433962264	1696	10287	5347,143471,9232,5695,5682,29882,9212,8697,5715,5698,5691,5704,5708,5687,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PLK1,PSMA8,PTTG1,PSMB7,PSMA1,ANAPC2,AURKB,CDC23,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.0004371039136282	-7.73533960251303	99	30	0.017688679245283	1696	10287	6209,6159,6187,11224,6181,23708,6204,6128,6169,6132,6138,6229,6157,6203,3921,6135,25873,6147,6167,5976,6161,6233,6139,6208,6176,6143,2197,6231,200916,26986	RPS15,RPL29,RPS2,RPL35,RPLP2,GSPT2,RPS10,RPL6,RPL38,RPL8,RPL15,RPS24,RPL27A,RPS9,RPSA,RPL11,RPL36,RPL23A,RPL37,UPF1,RPL32,RPS27A,RPL17,RPS14,RPLP1,RPL19,FAU,RPS26,RPL22L1,PABPC1
R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport	0.000449601226204211	-7.70714953206598	69	23	0.013561320754717	1696	10287	8615,83696,64689,90411,5861,9919,23243,966,22872,8774,11196,2801,4905,10972,9632,5537,55291,3998,10342,22870,1453,10959,10113	USO1,TRAPPC9,GORASP1,MCFD2,RAB1A,SEC16A,ANKRD28,CD59,SEC31A,NAPG,SEC23IP,GOLGA2,NSF,TMED10,SEC24C,PPP6C,PPP6R3,LMAN1,TFG,PPP6R1,CSNK1D,TMED2,PREB
R-HSA-68867	Assembly of the pre-replicative complex	0.000449601226204211	-7.70714953206598	69	23	0.013561320754717	1696	10287	143471,81620,1871,5695,5682,990,4998,4171,5698,5715,5691,5704,5708,5687,5707,6233,5714,5709,4174,1869,23595,1870,5700	PSMA8,CDT1,E2F3,PSMB7,PSMA1,CDC6,ORC1,MCM2,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD8,PSMD3,MCM5,E2F1,ORC3,E2F2,PSMC1
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.000449601226204211	-7.70714953206598	69	23	0.013561320754717	1696	10287	9150,5438,5436,5441,5440,6924,5395,5433,8621,672,55215,5430,11198,2962,8812,5439,4436,6917,1386,2966,51755,5892,6749	CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,ELOA,PMS2,POLR2D,CDK13,BRCA1,FANCI,POLR2A,SUPT16H,GTF2F1,CCNK,POLR2J,MSH2,TCEA1,ATF2,GTF2H2,CDK12,RAD51D,SSRP1
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.000481381898886986	-7.63884963430482	45	17	0.0100235849056604	1696	10287	55706,23511,8480,53371,7884,9631,8189,23165,23225,57122,9972,23636,10898,9818,79902,81929,8086	NDC1,NUP188,RAE1,NUP54,SLBP,NUP155,SYMPK,NUP205,NUP210,NUP107,NUP153,NUP62,CPSF4,NUP58,NUP85,SEH1L,AAAS
R-HSA-8854214	TBC/RABGAPs	0.000481381898886986	-7.63884963430482	45	17	0.0100235849056604	1696	10287	7248,4218,79735,7249,9230,26088,11021,7879,57533,5867,54662,5870,23062,81631,5869,8766,10133	TSC1,RAB8A,TBC1D17,TSC2,RAB11B,GGA1,RAB35,RAB7A,TBC1D14,RAB4A,TBC1D13,RAB6A,GGA2,MAP1LC3B,RAB5B,RAB11A,OPTN
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.000544290657899813	-7.51602715618453	34	14	0.00825471698113208	1696	10287	55706,23511,23225,8480,57122,53371,23636,9631,9972,79902,9818,8086,23165,81929	NDC1,NUP188,NUP210,RAE1,NUP107,NUP54,NUP62,NUP155,NUP153,NUP85,NUP58,AAAS,NUP205,SEH1L
R-HSA-5625970	RHO GTPases activate KTN1	0.000582779760165691	-7.44770121285696	11	7	0.00412735849056604	1696	10287	3831,3799,391,387,998,3895,5879	KLC1,KIF5B,RHOG,RHOA,CDC42,KTN1,RAC1
R-HSA-156711	Polo-like kinase mediated events	0.000603462559016072	-7.41282655909262	17	9	0.00530660377358491	1696	10287	286826,5347,2305,1063,4605,9088,891,5928,9133	LIN9,PLK1,FOXM1,CENPF,MYBL2,PKMYT1,CCNB1,RBBP4,CCNB2
R-HSA-5625900	RHO GTPases activate CIT	0.000603462559016072	-7.41282655909262	17	9	0.00530660377358491	1696	10287	387,389,9928,5879,9055,4627,1027,103910,388	RHOA,RHOC,KIF14,RAC1,PRC1,MYH9,CDKN1B,MYL12B,RHOB
R-HSA-1268020	Mitochondrial protein import	0.000617095616809493	-7.39048657554776	62	21	0.0123820754716981	1696	10287	26521,9804,29090,8604,51142,4580,506,10452,7416,6901,2671,54927,26517,100287932,100188893,10440,1431,1537,498,10651,92609	TIMM8B,TOMM20,TIMM21,SLC25A12,CHCHD2,MTX1,ATP5F1B,TOMM40,VDAC1,TAZ,GFER,CHCHD3,TIMM13,TIMM23,TOMM6,TIMM17A,CS,CYC1,ATP5F1A,MTX2,TIMM50
R-HSA-192823	Viral mRNA Translation	0.000619446476041143	-7.38668425926988	92	28	0.0165094339622642	1696	10287	6209,6159,11224,6187,6181,6132,6204,6128,6169,6138,6229,6157,6203,3921,6135,6147,25873,6167,6161,6139,6233,6208,2926,6176,6143,2197,6231,200916	RPS15,RPL29,RPL35,RPS2,RPLP2,RPL8,RPS10,RPL6,RPL38,RPL15,RPS24,RPL27A,RPS9,RPSA,RPL11,RPL23A,RPL36,RPL37,RPL32,RPL17,RPS27A,RPS14,GRSF1,RPLP1,RPL19,FAU,RPS26,RPL22L1
R-HSA-381119	Unfolded Protein Response (UPR)	0.000619446476041143	-7.38668425926988	92	28	0.0165094339622642	1696	10287	118460,10952,118,23480,30827,5393,84447,5073,27230,4000,4189,6745,10897,22872,23016,6464,29927,9797,51013,8570,439,22926,56005,10130,10106,9114,10113,1639	EXOSC6,SEC61B,ADD1,SEC61G,CXXC1,EXOSC9,SYVN1,PARN,SERP1,LMNA,DNAJB9,SSR1,YIF1A,SEC31A,EXOSC7,SHC1,SEC61A1,TATDN2,EXOSC1,KHSRP,ASNA1,ATF6,MYDGF,PDIA6,CTDSP2,ATP6V0D1,PREB,DCTN1
R-HSA-1660662	Glycosphingolipid metabolism	0.000647781670421463	-7.34195684674705	46	17	0.0100235849056604	1696	10287	2581,3074,64781,2629,427,285362,25870,23344,153642,4758,5476,51228,5660,55627,3073,2760,57488	GALC,HEXB,CERK,GBA,ASAH1,SUMF1,SUMF2,ESYT1,ARSK,NEU1,CTSA,GLTP,PSAP,SMPD4,HEXA,GM2A,ESYT2
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.000694698930791044	-7.27203199936113	31	13	0.00766509433962264	1696	10287	27154,1107,208,5300,9219,5371,79837,29117,5928,53615,5305,3066,64769	BRPF3,CHD3,AKT2,PIN1,MTA2,PML,PIP4K2C,BRD7,RBBP4,MBD3,PIP4K2A,HDAC2,MEAF6
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.000727651943205891	-7.22568772408574	24	11	0.00648584905660377	1696	10287	391,387,998,3984,389,5879,4627,23365,6093,103910,388	RHOG,RHOA,CDC42,LIMK1,RHOC,RAC1,MYH9,ARHGEF12,ROCK1,MYL12B,RHOB
R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.000736655254083273	-7.21339054443524	4	4	0.00235849056603774	1696	10287	3845,4893,4763,3265	KRAS,NRAS,NF1,HRAS
R-HSA-5693532	DNA Double-Strand Break Repair	0.000753833130158218	-7.19033952723712	167	44	0.0259433962264151	1696	10287	63967,9682,2138,6613,29086,116028,641,7329,80010,6118,5111,9577,890,7516,8914,23514,55775,2067,5983,51426,10635,5591,7156,672,64421,5982,6117,7520,5889,79728,5426,6233,3014,9031,7517,3838,11200,5536,1017,348654,7518,2139,5892,10721	CLSPN,KDM4A,EYA1,SUMO2,BABAM1,RMI2,BLM,UBE2I,RMI1,RPA2,PCNA,BABAM2,CCNA2,XRCC2,TIMELESS,SPIDR,TDP1,ERCC1,RFC3,POLK,RAD51AP1,PRKDC,TOP3A,BRCA1,DCLRE1C,RFC2,RPA1,XRCC5,RAD51C,PALB2,POLE,RPS27A,H2AFX,BAZ1B,XRCC3,KPNA2,CHEK2,PPP5C,CDK2,GEN1,XRCC4,EYA2,RAD51D,POLQ
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.000828165382780655	-7.09629768586613	76	24	0.0141509433962264	1696	10287	143471,9232,5695,5682,29882,8697,891,5715,5698,5691,5704,5708,5687,890,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PSMA8,PTTG1,PSMB7,PSMA1,ANAPC2,CDC23,CCNB1,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-2408522	Selenoamino acid metabolism	0.000868482756438297	-7.04876282689784	121	34	0.0200471698113208	1696	10287	3735,6209,6187,6181,6138,79048,6135,6147,3376,6139,6143,191,200916,51520,6159,11224,6132,6169,6128,6204,6229,6157,6203,3921,25873,6167,2058,6161,6233,5859,6208,6176,2197,6231	KARS,RPS15,RPS2,RPLP2,RPL15,SECISBP2,RPL11,RPL23A,IARS,RPL17,RPL19,AHCY,RPL22L1,LARS,RPL29,RPL35,RPL8,RPL38,RPL6,RPS10,RPS24,RPL27A,RPS9,RPSA,RPL36,RPL37,EPRS,RPL32,RPS27A,QARS,RPS14,RPLP1,FAU,RPS26
R-HSA-157118	Signaling by NOTCH	0.000893456839218346	-7.02041252982717	112	32	0.0188679245283019	1696	10287	142678,892,9612,6868,2648,102,9978,51107,27161,1871,4242,8454,2683,5870,4853,83464,23509,488,6233,51564,7027,1869,23220,6400,3516,1385,7029,9794,409,8650,3066,10959	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,AGO2,E2F3,MFNG,CUL1,B4GALT1,RAB6A,NOTCH2,APH1B,POFUT1,ATP2A2,RPS27A,HDAC7,TFDP1,E2F1,DTX4,SEL1L,RBPJ,CREB1,TFDP2,MAML1,ARRB2,NUMB,HDAC2,TMED2
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.000936833446942608	-6.9730050429208	68	22	0.0129716981132075	1696	10287	143471,9232,5695,5682,29882,8697,5715,5698,5691,5704,5708,5687,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PSMA8,PTTG1,PSMB7,PSMA1,ANAPC2,CDC23,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.000981312214749639	-6.92661988731107	90	27	0.0159198113207547	1696	10287	5347,11116,22919,4659,8655,10540,8454,54930,891,79866,5566,55142,10133,93323,4218,5108,9738,6233,55835,4957,8636,80254,54820,9133,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,PPP1R12A,DYNLL1,DCTN2,CUL1,HAUS4,CCNB1,BORA,PRKACA,HAUS2,OPTN,HAUS8,RAB8A,PCM1,CCP110,RPS27A,CENPJ,ODF2,SSNA1,CEP63,NDE1,CCNB2,TUBB,CSNK1D,DCTN1
R-HSA-69205	G1/S-Specific Transcription	0.00103124435305247	-6.87698909615828	18	9	0.00530660377358491	1696	10287	5111,81620,7027,1869,6241,990,4998,7029,26271	PCNA,CDT1,TFDP1,E2F1,RRM2,CDC6,ORC1,TFDP2,FBXO5
R-HSA-6784531	tRNA processing in the nucleus	0.00103662626860187	-6.87178381141276	60	20	0.0117924528301887	1696	10287	54913,55706,23511,8480,53371,9631,79074,23165,23225,10248,57122,51493,23636,9972,10898,116461,79902,9818,8086,81929	RPP25,NDC1,NUP188,RAE1,NUP54,NUP155,C2orf49,NUP205,NUP210,POP7,NUP107,RTCB,NUP62,NUP153,CPSF4,TSEN15,NUP85,NUP58,AAAS,SEH1L
R-HSA-2408557	Selenocysteine synthesis	0.0010822571615787	-6.82870645435874	95	28	0.0165094339622642	1696	10287	6209,6159,6187,11224,6181,6204,6128,6169,6132,6138,6229,79048,6157,6203,3921,6135,25873,6147,6167,6161,6233,6139,6208,6176,6143,2197,6231,200916	RPS15,RPL29,RPS2,RPL35,RPLP2,RPS10,RPL6,RPL38,RPL8,RPL15,RPS24,SECISBP2,RPL27A,RPS9,RPSA,RPL11,RPL36,RPL23A,RPL37,RPL32,RPS27A,RPL17,RPS14,RPLP1,RPL19,FAU,RPS26,RPL22L1
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.00109138627010172	-6.82030658337032	73	23	0.013561320754717	1696	10287	57508,5438,55197,5436,5441,5440,22936,55726,5433,51593,6621,5430,2962,8812,5439,25896,26173,79035,64859,57117,79664,6878,58490	INTS2,POLR2I,RPRD1A,POLR2G,POLR2L,POLR2K,ELL2,INTS13,POLR2D,SRRT,SNAPC4,POLR2A,GTF2F1,CCNK,POLR2J,INTS7,INTS1,NABP2,NABP1,INTS12,ICE2,TAF6,RPRD1B
R-HSA-109703	PKB-mediated events	0.00111727559163408	-6.79686206449756	40	15	0.00884433962264151	1696	10287	7248,5564,7249,208,5562,389541,8649,51719,64121,6794,84335,5140,6009,64223,29904	TSC1,PRKAB1,TSC2,AKT2,PRKAA1,LAMTOR4,LAMTOR3,CAB39,RRAGC,STK11,AKT1S1,PDE3B,RHEB,MLST8,EEF2K
R-HSA-6798695	Neutrophil degranulation	0.00112312532106461	-6.79164001455928	487	106	0.0625	1696	10287	51816,391,51552,102,8655,5879,3074,56954,387921,2992,1432,56888,54918,8895,5036,5906,5707,8907,25798,64114,2760,8514,8904,22875,10576,7077,4893,23526,7879,10450,5695,84418,535,54472,5869,221,1650,79980,10555,6836,53917,5709,51719,124583,527,6093,8566,4048,5594,823,203068,258010,4282,80331,9535,4126,11333,8649,2683,427,8621,4125,5870,5663,3105,374395,2799,966,5708,1520,10092,10075,26578,1265,9961,79888,6709,23191,2512,387,9761,8804,79169,23593,5315,25852,10694,4758,3304,7520,55832,847,3106,22931,51382,51125,84061,9342,8773,47,10857,3614,5476,2821,5660,5223	ADA2,RHOG,RAB14,ADAM10,DYNLL1,RAC1,HEXB,NIT2,NHLRC3,GYG1,MAPK14,KCMF1,CMTM6,CPNE3,PA2G4,RAP1A,PSMD1,AP1M1,BRI3,TMBIM1,GM2A,KCNAB2,CPNE1,ENPP4,CCT2,TIMP2,NRAS,ARHGAP45,RAB7A,PPIE,PSMB7,CYSTM1,ATP6V0A1,TOLLIP,RAB5B,ALDH3B1,DDOST,DSN1,AGPAT2,SURF4,RAB24,PSMD3,CAB39,CANT1,ATP6V0C,ROCK1,PDXK,LTA4H,MAPK1,CAPN1,TUBB,SVIP,MIF,DNAJC5,GMFG,MANBA,PDAP1,LAMTOR3,B4GALT1,ASAH1,CDK13,MAN2B1,RAB6A,PSEN1,HLA-A,TMEM179B,GNS,CD59,PSMD2,CTSS,ARPC5,HUWE1,OSTF1,CNN2,MVP,LPCAT1,SPTAN1,CYFIP1,FTL,RHOA,MLEC,CREG1,C1orf35,HEBP2,PKM,ARMC8,CCT8,NEU1,HSPA1B,XRCC5,CAND1,CAT,HLA-B,RAB18,ATP6V1D,GOLGA7,MAGT1,SNAP29,SNAP23,ACLY,PGRMC1,IMPDH1,CTSA,GPI,PSAP,PGAM1
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.00113148221386742	-6.78422681208854	48	17	0.0100235849056604	1696	10287	5441,2648,5440,9219,53615,7270,221830,7343,54700,10849,1107,9112,84172,5928,30834,2966,3066	POLR2L,KAT2A,POLR2K,MTA2,MBD3,TTF1,TWISTNB,UBTF,RRN3,CD3EAP,CHD3,MTA1,POLR1B,RBBP4,ZNRD1,GTF2H2,HDAC2
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.00113513490609046	-6.78100377512047	44	16	0.00943396226415094	1696	10287	55706,23511,8480,53371,9631,8189,23165,23225,57122,9972,23636,10898,9818,79902,81929,8086	NDC1,NUP188,RAE1,NUP54,NUP155,SYMPK,NUP205,NUP210,NUP107,NUP153,NUP62,CPSF4,NUP58,NUP85,SEH1L,AAAS
R-HSA-69298	Association of licensing factors with the pre-replicative complex	0.00115691339678563	-6.76199968509707	15	8	0.00471698113207547	1696	10287	990,4998,23595,1870,6233,81620,1869,1871	CDC6,ORC1,ORC3,E2F2,RPS27A,CDT1,E2F1,E2F3
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.0012375055550768	-6.69465757458055	65	21	0.0123820754716981	1696	10287	9150,5438,5436,5441,5440,6924,5433,23168,55840,79577,5430,55677,11198,2962,8812,54623,5439,9646,6917,2966,6749	CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,RTF1,EAF2,CDC73,POLR2A,IWS1,SUPT16H,GTF2F1,CCNK,PAF1,POLR2J,CTR9,TCEA1,GTF2H2,SSRP1
R-HSA-112382	Formation of RNA Pol II elongation complex	0.0012375055550768	-6.69465757458055	65	21	0.0123820754716981	1696	10287	9150,5438,5436,5441,5440,6924,5433,23168,55840,79577,5430,55677,11198,2962,8812,54623,5439,9646,6917,2966,6749	CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,RTF1,EAF2,CDC73,POLR2A,IWS1,SUPT16H,GTF2F1,CCNK,PAF1,POLR2J,CTR9,TCEA1,GTF2H2,SSRP1
R-HSA-72764	Eukaryotic Translation Termination	0.00129223106003078	-6.65138505057841	96	28	0.0165094339622642	1696	10287	6209,6159,11224,6187,6181,23708,6132,6204,6128,6169,6138,6229,6157,6203,3921,6135,6147,25873,6167,6161,6139,6233,6208,6176,6143,2197,6231,200916	RPS15,RPL29,RPL35,RPS2,RPLP2,GSPT2,RPL8,RPS10,RPL6,RPL38,RPL15,RPS24,RPL27A,RPS9,RPSA,RPL11,RPL23A,RPL36,RPL37,RPL32,RPL17,RPS27A,RPS14,RPLP1,RPL19,FAU,RPS26,RPL22L1
R-HSA-156842	Eukaryotic Translation Elongation	0.00129223106003078	-6.65138505057841	96	28	0.0165094339622642	1696	10287	6209,6159,11224,6187,6181,6132,6204,6128,6169,6138,6229,6157,6203,3921,6135,6147,25873,6167,6161,6139,6233,6208,6176,6143,2197,6231,200916,1936	RPS15,RPL29,RPL35,RPS2,RPLP2,RPL8,RPS10,RPL6,RPL38,RPL15,RPS24,RPL27A,RPS9,RPSA,RPL11,RPL23A,RPL36,RPL37,RPL32,RPL17,RPS27A,RPS14,RPLP1,RPL19,FAU,RPS26,RPL22L1,EEF1D
R-HSA-156902	Peptide chain elongation	0.00141324878902011	-6.56186411928516	92	27	0.0159198113207547	1696	10287	6209,6159,11224,6187,6181,6132,6204,6128,6169,6138,6229,6157,6203,3921,6135,6147,25873,6167,6161,6139,6233,6208,6176,6143,2197,6231,200916	RPS15,RPL29,RPL35,RPS2,RPLP2,RPL8,RPS10,RPL6,RPL38,RPL15,RPS24,RPL27A,RPS9,RPSA,RPL11,RPL23A,RPL36,RPL37,RPL32,RPL17,RPS27A,RPS14,RPLP1,RPL19,FAU,RPS26,RPL22L1
R-HSA-1280218	Adaptive Immune System	0.00142017640530301	-6.55697418599814	810	165	0.0972877358490566	1696	10287	142678,7325,7249,81559,6890,8454,65264,55585,11004,26263,805,5906,5707,998,5296,8907,1785,163,26190,3835,140459,64223,80228,4893,4690,9978,208,7428,56992,7335,899,89122,7454,6233,5714,7174,3688,57542,26224,5700,7323,23480,3133,3831,9493,29127,5715,3693,7408,92912,51320,51088,223082,25793,84876,23194,22920,9690,90678,79837,5682,3845,3384,5691,5704,22872,996,1445,8773,6478,5476,7534,9604,55905,154881,90933,84231,5894,8655,23304,5879,162,4067,5566,7409,4193,5687,6464,6477,79876,1027,6891,51434,25897,10768,51132,1639,10952,143471,7879,64320,8452,5695,8697,79754,5698,53339,5515,3796,8881,5525,29927,23118,5709,1174,22954,57154,5594,1175,1783,9371,9320,9903,10540,27161,11119,9354,375,84335,2309,5305,3105,23396,3799,8916,5708,2261,1520,27252,5728,10075,9632,5781,26046,89910,1385,9020,54620,9040,5170,26268,29882,3832,5595,1514,3106,23014,150726,81930,9817,84078,11065,975,3265,29945	MIB2,UBE2E2,TSC2,TRIM11,TAP1,CUL1,UBE2Z,UBE2Q1,KIF2C,FBXO22,CALM2,RAP1A,PSMD1,CDC42,PIK3R2,AP1M1,DNM2,AP2B1,FBXW2,KIF22,ASB6,MLST8,ORAI2,NRAS,NCK1,RBX1,AKT2,VHL,KIF15,UBE2V1,CCNF,TRIM4,WAS,RPS27A,PSMD8,TPP2,ITGB1,KLHL42,FBXL3,PSMC1,UBE2D3,SEC61G,HLA-E,KLC1,KIF23,RACGAP1,PSMD9,ITGB5,VASP,UBE2Q2,MEX3C,KLHL5,ZNRF2,FBXO7,ORAI1,FBXL7,KIFAP3,UBE3C,LRSAM1,PIP4K2C,PSMA1,KRAS,ICAM2,PSMB3,PSMC4,SEC31A,CDC27,CSK,SNAP23,SIAH2,CTSA,YWHAZ,RNF14,RNF114,KCTD7,TRIM41,TRAF7,RAF1,DYNLL1,UBR2,RAC1,AP1B1,LYN,PRKACA,VAV1,MDM2,PSMA6,SHC1,SIAH1,UBA5,CDKN1B,TAP2,ANAPC7,RNF19A,AHCYL1,RLIM,DCTN1,SEC61B,PSMA8,RAB7A,RNF25,CUL3,PSMB7,CDC23,ASB13,PSMB9,BTBD1,PPP2CA,KIF2A,CDC16,PPP2R5A,SEC61A1,TAB2,PSMD3,AP1S1,TRIM32,SMURF1,MAPK1,AP2S1,DYNC1LI2,KIF3B,TRIP12,KLHL21,DCTN2,AGO2,BTN3A1,UBE4A,ARF1,AKT1S1,FOXO3,PIP4K2A,HLA-A,PIP5K1C,KIF5B,HERC3,PSMD2,FGFR3,CTSS,KLHL20,PTEN,HUWE1,SEC24C,PTPN11,LTN1,UBE3B,CREB1,MAP3K14,FBXL19,UBE2M,PDPK1,FBXO9,ANAPC2,KIF11,MAPK3,CTSL,HLA-B,FBXO21,FBXO41,KIF18A,KEAP1,KBTBD7,UBE2C,CD81,HRAS,ANAPC4
R-HSA-194315	Signaling by Rho GTPases	0.00145359523436101	-6.53371531939552	427	94	0.0554245283018868	1696	10287	10163,391,3015,9322,10096,5879,4627,83540,11004,3895,79003,805,7409,25909,998,9928,5296,57122,1027,10006,1856,81929,5347,55114,4690,57120,23526,57551,7456,397,9212,94239,79682,3796,5515,7454,5525,79980,3984,3688,3014,60,6093,1855,3020,5594,103910,22919,4659,389,7204,1063,7410,55143,3831,29127,4650,10787,11243,54908,6242,3799,10092,9138,9055,9181,9735,79019,79902,10499,10726,5170,23191,387,10276,23365,5905,26999,55288,4221,10552,89941,388,55843,5595,81930,332,116985,7534,80152,54820,4649,7533,57636	WASF2,RHOG,H2AFZ,TRIP10,ACTR3,RAC1,MYH9,NUF2,KIF2C,KTN1,MIS12,CALM2,VAV1,AHCTF1,CDC42,KIF14,PIK3R2,NUP107,CDKN1B,ABI1,DVL2,SEH1L,PLK1,ARHGAP17,NCK1,GOPC,ARHGAP45,TAOK1,WIPF1,ARHGDIB,AURKB,H2AFV,CENPU,KIF2A,PPP2CA,WAS,PPP2R5A,DSN1,LIMK1,ITGB1,H2AFX,ACTB,ROCK1,DVL1,H3F3A,MAPK1,MYL12B,MAPRE1,PPP1R12A,RHOC,TRIO,CENPF,VAV2,CDCA8,KLC1,RACGAP1,MYO9B,NCKAP1,PMF1,SPDL1,RTKN,KIF5B,ARPC5,ARHGEF1,PRC1,ARHGEF2,KNTC1,CENPM,NUP85,NCOA2,NUDC,PDPK1,CYFIP1,RHOA,NET1,ARHGEF12,RANGAP1,CYFIP2,RHOT1,MEN1,ARPC1A,RHOT2,RHOB,ARHGAP15,MAPK3,KIF18A,BIRC5,ARAP1,YWHAZ,CENPT,NDE1,MYO9A,YWHAH,ARHGAP23
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	0.00147055297823309	-6.52211677325905	49	17	0.0100235849056604	1696	10287	8802,4191,3419,3939,2739,4967,3029,6389,8050,51660,6390,5164,1431,8801,6566,3420,3945	SUCLG1,MDH2,IDH3A,LDHA,GLO1,OGDH,HAGH,SDHA,PDHX,MPC1,SDHB,PDK2,CS,SUCLG2,SLC16A1,IDH3B,LDHB
R-HSA-6790901	rRNA modification in the nucleus and cytosol	0.00163592552404455	-6.41554656503795	62	20	0.0117924528301887	1696	10287	51202,6187,4839,84135,9790,57050,54433,6203,88745,11103,27042,27340,25926,51096,10607,6208,2091,22984,84916,11056	DDX47,RPS2,NOP2,UTP15,BMS1,UTP3,GAR1,RPS9,RRP36,KRR1,UTP25,UTP20,NOL11,UTP18,TBL3,RPS14,FBL,PDCD11,UTP4,DDX52
R-HSA-176412	Phosphorylation of the APC/C	0.00167475414383127	-6.39208890428055	19	9	0.00530660377358491	1696	10287	5347,8881,996,29882,51434,891,8697,11065,29945	PLK1,CDC16,CDC27,ANAPC2,ANAPC7,CCNB1,CDC23,UBE2C,ANAPC4
R-HSA-71403	Citric acid cycle (TCA cycle)	0.00167475414383127	-6.39208890428055	19	9	0.00530660377358491	1696	10287	6390,8802,4191,3419,1431,8801,4967,3420,6389	SDHB,SUCLG1,MDH2,IDH3A,CS,SUCLG2,OGDH,IDH3B,SDHA
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.00189688437979526	-6.26754253886128	7	5	0.00294811320754717	1696	10287	5347,10783,891,9133,140609	PLK1,NEK6,CCNB1,CCNB2,NEK7
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.00192543844089449	-6.25260157567247	34	13	0.00766509433962264	1696	10287	5889,79728,10635,7516,116028,7156,7517,672,641,348654,80010,23514,5892	RAD51C,PALB2,RAD51AP1,XRCC2,RMI2,TOP3A,XRCC3,BRCA1,BLM,GEN1,RMI1,SPIDR,RAD51D
R-HSA-2132295	MHC class II antigen presentation	0.00194736938061043	-6.24127585275858	103	29	0.0170990566037736	1696	10287	9371,8655,7879,10540,56992,3831,9493,29127,11004,375,162,3832,22872,3796,3799,1514,1520,81930,9632,1785,8907,163,1174,5476,3835,22920,1175,1783,1639	KIF3B,DYNLL1,RAB7A,DCTN2,KIF15,KLC1,KIF23,RACGAP1,KIF2C,ARF1,AP1B1,KIF11,SEC31A,KIF2A,KIF5B,CTSL,CTSS,KIF18A,SEC24C,DNM2,AP1M1,AP2B1,AP1S1,CTSA,KIF22,KIFAP3,AP2S1,DYNC1LI2,DCTN1
R-HSA-70153	Glucose transport	0.00194811664701775	-6.2408921951553	46	16	0.00943396226415094	1696	10287	55706,23511,8480,6513,53371,9631,55974,23165,23225,57122,9972,23636,79902,9818,81929,8086	NDC1,NUP188,RAE1,SLC2A1,NUP54,NUP155,SLC50A1,NUP205,NUP210,NUP107,NUP153,NUP62,NUP85,NUP58,SEH1L,AAAS
R-HSA-983189	Kinesins	0.00197919343009588	-6.22506587580616	42	15	0.00884433962264151	1696	10287	3833,3796,3799,9371,81930,146909,23303,56992,3831,9493,29127,3835,22920,11004,3832	KIFC1,KIF2A,KIF5B,KIF3B,KIF18A,KIF18B,KIF13B,KIF15,KLC1,KIF23,RACGAP1,KIF22,KIFAP3,KIF2C,KIF11
R-HSA-8863678	Neurodegenerative Diseases	0.00207632126061639	-6.17715757583579	23	10	0.00589622641509434	1696	10287	1020,824,2801,831,994,2309,351,4000,5052,823	CDK5,CAPN2,GOLGA2,CAST,CDC25B,FOXO3,APP,LMNA,PRDX1,CAPN1
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	0.00207632126061639	-6.17715757583579	23	10	0.00589622641509434	1696	10287	1020,824,2801,831,994,2309,351,4000,5052,823	CDK5,CAPN2,GOLGA2,CAST,CDC25B,FOXO3,APP,LMNA,PRDX1,CAPN1
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	0.00223089332011915	-6.10535318174398	13	7	0.00412735849056604	1696	10287	830,1650,5594,5589,351,5595,829	CAPZA2,DDOST,MAPK1,PRKCSH,APP,MAPK3,CAPZA1
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.00223089332011915	-6.10535318174398	13	7	0.00412735849056604	1696	10287	805,4773,5530,4775,5532,10768,5534	CALM2,NFATC2,PPP3CA,NFATC3,PPP3CB,AHCYL1,PPP3R1
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.00232824117508274	-6.06264215693467	68	21	0.0123820754716981	1696	10287	5983,51426,10635,116028,7156,672,641,5982,80010,6117,6118,5889,5111,79728,5426,6233,7516,7517,348654,23514,5892	RFC3,POLK,RAD51AP1,RMI2,TOP3A,BRCA1,BLM,RFC2,RMI1,RPA1,RPA2,RAD51C,PCNA,PALB2,POLE,RPS27A,XRCC2,XRCC3,GEN1,SPIDR,RAD51D
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.00235512580001725	-6.05116113467411	27	11	0.00648584905660377	1696	10287	5889,79728,10635,7516,116028,7156,7517,672,641,80010,5892	RAD51C,PALB2,RAD51AP1,XRCC2,RMI2,TOP3A,XRCC3,BRCA1,BLM,RMI1,RAD51D
R-HSA-400685	Sema4D in semaphorin signaling	0.00235512580001725	-6.05116113467411	27	11	0.00648584905660377	1696	10287	391,387,998,3984,389,5879,4627,23365,6093,103910,388	RHOG,RHOA,CDC42,LIMK1,RHOC,RAC1,MYH9,ARHGEF12,ROCK1,MYL12B,RHOB
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.00250641927334447	-5.98890012870358	64	20	0.0117924528301887	1696	10287	5695,5682,29882,8697,5715,5698,5691,5704,5708,5687,8881,5707,996,6233,5709,5714,51434,11065,5700,29945	PSMB7,PSMA1,ANAPC2,CDC23,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CDC16,PSMD1,CDC27,RPS27A,PSMD3,PSMD8,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.00250915902180742	-5.98780763305334	47	16	0.00943396226415094	1696	10287	2648,27161,1871,4242,2683,5870,4853,23509,488,7027,6400,1869,3516,9794,7029,10959	KAT2A,AGO2,E2F3,MFNG,B4GALT1,RAB6A,NOTCH2,POFUT1,ATP2A2,TFDP1,SEL1L,E2F1,RBPJ,MAML1,TFDP2,TMED2
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.00258370816935047	-5.95852963699758	43	15	0.00884433962264151	1696	10287	6118,5889,5983,79728,10635,7516,116028,7156,7517,672,641,5982,80010,5892,6117	RPA2,RAD51C,RFC3,PALB2,RAD51AP1,XRCC2,RMI2,TOP3A,XRCC3,BRCA1,BLM,RFC2,RMI1,RAD51D,RPA1
R-HSA-5693537	Resolution of D-Loop Structures	0.00260760540983179	-5.94932294627584	35	13	0.00766509433962264	1696	10287	5889,79728,10635,7516,116028,7156,7517,672,641,348654,80010,23514,5892	RAD51C,PALB2,RAD51AP1,XRCC2,RMI2,TOP3A,XRCC3,BRCA1,BLM,GEN1,RMI1,SPIDR,RAD51D
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.00261422133663284	-5.94678899382498	73	22	0.0129716981132075	1696	10287	143471,5695,5682,29882,8697,5715,5698,5691,5704,5708,5687,890,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PSMA8,PSMB7,PSMA1,ANAPC2,CDC23,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-165159	mTOR signalling	0.00262125514626605	-5.94410201246307	39	14	0.00825471698113208	1696	10287	7248,5564,7249,208,5562,389541,8649,51719,64121,6794,84335,6009,64223,29904	TSC1,PRKAB1,TSC2,AKT2,PRKAA1,LAMTOR4,LAMTOR3,CAB39,RRAGC,STK11,AKT1S1,RHEB,MLST8,EEF2K
R-HSA-69236	G1 Phase	0.00262125514626605	-5.94410201246307	39	14	0.00825471698113208	1696	10287	5515,1031,5925,5933,6233,1874,7027,1869,1871,8454,1027,7029,1870,1029	PPP2CA,CDKN2C,RB1,RBL1,RPS27A,E2F4,TFDP1,E2F1,E2F3,CUL1,CDKN1B,TFDP2,E2F2,CDKN2A
R-HSA-69231	Cyclin D associated events in G1	0.00262125514626605	-5.94410201246307	39	14	0.00825471698113208	1696	10287	5515,1031,5925,5933,6233,1874,7027,1869,1871,8454,1027,7029,1870,1029	PPP2CA,CDKN2C,RB1,RBL1,RPS27A,E2F4,TFDP1,E2F1,E2F3,CUL1,CDKN1B,TFDP2,E2F2,CDKN2A
R-HSA-380287	Centrosome maturation	0.00263914001440623	-5.93730216701151	82	24	0.0141509433962264	1696	10287	5347,11116,22919,8655,10540,114791,54930,891,984,5566,728642,55142,10844,93323,5108,9738,55835,4957,8636,80254,54820,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,DYNLL1,DCTN2,TUBGCP5,HAUS4,CCNB1,CDK11B,PRKACA,CDK11A,HAUS2,TUBGCP2,HAUS8,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,TUBB,CSNK1D,DCTN1
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.00263914001440623	-5.93730216701151	82	24	0.0141509433962264	1696	10287	5347,11116,22919,8655,10540,114791,54930,891,984,5566,728642,55142,10844,93323,5108,9738,55835,4957,8636,80254,54820,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,DYNLL1,DCTN2,TUBGCP5,HAUS4,CCNB1,CDK11B,PRKACA,CDK11A,HAUS2,TUBGCP2,HAUS8,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,TUBB,CSNK1D,DCTN1
R-HSA-5689880	Ub-specific processing proteases	0.00294785022902234	-5.82667911021213	223	53	0.03125	1696	10287	23586,7874,9804,1540,63967,84196,5715,8678,329,57599,8078,27430,5708,4193,5707,5687,890,9738,5728,8313,9736,330,2648,143471,84132,5695,7417,5682,9100,23326,154,7416,55288,5698,27005,5691,5704,9146,9817,3416,4087,6233,5714,8312,5709,6478,10868,4086,8237,409,5700,4089,8975	DDX58,USP7,TOMM20,CYLD,CLSPN,USP48,PSMD9,BECN1,BIRC2,WDR48,USP5,MAT2B,PSMD2,MDM2,PSMD1,PSMA6,CCNA2,CCP110,PTEN,AXIN2,USP34,BIRC3,KAT2A,PSMA8,USP42,PSMB7,VDAC2,PSMA1,USP10,USP22,ADRB2,VDAC1,RHOT1,PSMB9,USP21,PSMB3,PSMC4,HGS,KEAP1,IDE,SMAD2,RPS27A,PSMD8,AXIN1,PSMD3,SIAH2,USP20,SMAD1,USP11,ARRB2,PSMC1,SMAD4,USP13
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	0.0030392324297028	-5.79615028567437	52	17	0.0100235849056604	1696	10287	1728,143471,5695,5682,4953,5698,5715,5691,5704,5708,5687,5707,5709,5714,4947,4946,5700	NQO1,PSMA8,PSMB7,PSMA1,ODC1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,PSMD3,PSMD8,OAZ2,OAZ1,PSMC1
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	0.00315290551879676	-5.7594308643624	74	22	0.0129716981132075	1696	10287	143471,5695,5682,29882,8697,5715,5698,5691,5704,5708,5687,890,8881,5707,996,6233,5714,5709,51434,11065,5700,29945	PSMA8,PSMB7,PSMA1,ANAPC2,CDC23,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,CDC16,PSMD1,CDC27,RPS27A,PSMD8,PSMD3,ANAPC7,UBE2C,PSMC1,ANAPC4
R-HSA-68911	G2 Phase	0.00319842916749898	-5.74509547485659	5	4	0.00235849056603774	1696	10287	890,1017,1869,1871	CCNA2,CDK2,E2F1,E2F3
R-HSA-5655862	Translesion synthesis by POLK	0.00320613970646496	-5.74268764917996	17	8	0.00471698113207547	1696	10287	6118,5111,5983,5982,51426,6233,10459,6117	RPA2,PCNA,RFC3,RFC2,POLK,RPS27A,MAD2L2,RPA1
R-HSA-5627117	RHO GTPases Activate ROCKs	0.00320613970646496	-5.74268764917996	17	8	0.00471698113207547	1696	10287	4627,6093,387,4659,3984,103910,389,388	MYH9,ROCK1,RHOA,PPP1R12A,LIMK1,MYL12B,RHOC,RHOB
R-HSA-69481	G2/M Checkpoints	0.00326400369869843	-5.72480070870125	169	42	0.0247641509433962	1696	10287	55388,63967,29086,10926,116028,4998,641,891,5715,80010,6118,5708,5707,9577,5687,4174,51512,23595,5983,143471,7156,5695,5682,990,9088,672,4171,5698,5982,5691,5704,6117,6233,5714,5709,3014,7534,11200,1017,7533,9133,5700	MCM10,CLSPN,BABAM1,DBF4,RMI2,ORC1,BLM,CCNB1,PSMD9,RMI1,RPA2,PSMD2,PSMD1,BABAM2,PSMA6,MCM5,GTSE1,ORC3,RFC3,PSMA8,TOP3A,PSMB7,PSMA1,CDC6,PKMYT1,BRCA1,MCM2,PSMB9,RFC2,PSMB3,PSMC4,RPA1,RPS27A,PSMD8,PSMD3,H2AFX,YWHAZ,CHEK2,CDK2,YWHAH,CCNB2,PSMC1
R-HSA-6803529	FGFR2 alternative splicing	0.00330896273375995	-5.71112051219132	28	11	0.00648584905660377	1696	10287	5438,5436,5441,5439,5440,5433,3185,7072,4670,5430,2962	POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,HNRNPF,TIA1,HNRNPM,POLR2A,GTF2F1
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.00330896273375995	-5.71112051219132	28	11	0.00648584905660377	1696	10287	7248,5564,7249,5562,389541,8649,51719,64121,6794,6009,64223	TSC1,PRKAB1,TSC2,PRKAA1,LAMTOR4,LAMTOR3,CAB39,RRAGC,STK11,RHEB,MLST8
R-HSA-6802952	Signaling by BRAF and RAF fusions	0.00331133993088495	-5.71040235855165	61	19	0.0112028301886792	1696	10287	55109,4893,57085,5894,22906,3845,27044,8087,23499,5605,4000,5595,5906,1445,1185,5594,409,3265,56829	AGGF1,NRAS,AGTRAP,RAF1,TRAK1,KRAS,SND1,FXR1,MACF1,MAP2K2,LMNA,MAPK3,RAP1A,CSK,CLCN6,MAPK1,ARRB2,HRAS,ZC3HAV1
R-HSA-72702	Ribosomal scanning and start codon recognition	0.00331133993088495	-5.71040235855165	61	19	0.0112028301886792	1696	10287	6209,51386,6187,8664,6204,6229,7458,8666,6203,3921,8667,8661,27335,8894,6233,6208,1983,2197,6231	RPS15,EIF3L,RPS2,EIF3D,RPS10,RPS24,EIF4H,EIF3G,RPS9,RPSA,EIF3H,EIF3A,EIF3K,EIF2S2,RPS27A,RPS14,EIF5,FAU,RPS26
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.00331133993088495	-5.71040235855165	61	19	0.0112028301886792	1696	10287	5347,22919,143471,5695,5682,891,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,51512,9133,5700	PLK1,MAPRE1,PSMA8,PSMB7,PSMA1,CCNB1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,GTSE1,CCNB2,PSMC1
R-HSA-167287	HIV elongation arrest and recovery	0.0034310902910944	-5.67487719919024	40	14	0.00825471698113208	1696	10287	8812,9150,5438,5439,5436,5441,5440,6924,5433,6917,5430,2962,6749,11198	CCNK,CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-167290	Pausing and recovery of HIV elongation	0.0034310902910944	-5.67487719919024	40	14	0.00825471698113208	1696	10287	8812,9150,5438,5439,5436,5441,5440,6924,5433,6917,5430,2962,6749,11198	CCNK,CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-5658442	Regulation of RAS by GAPs	0.00343641832614927	-5.67332553426462	70	21	0.0123820754716981	1696	10287	4893,143471,9978,4763,5695,8452,5682,3845,5715,5698,5691,5704,5708,5687,5707,6233,5714,5709,84078,5700,3265	NRAS,PSMA8,RBX1,NF1,PSMB7,CUL3,PSMA1,KRAS,PSMD9,PSMB9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD8,PSMD3,KBTBD7,PSMC1,HRAS
R-HSA-69190	DNA strand elongation	0.00344361418191282	-5.67123372484977	32	12	0.00707547169811321	1696	10287	9837,23649,6118,5111,5983,5558,4174,4171,5982,84296,6117,5557	GINS1,POLA2,RPA2,PCNA,RFC3,PRIM2,MCM5,MCM2,RFC2,GINS4,RPA1,PRIM1
R-HSA-936440	Negative regulators of RIG-I/MDA5 signaling	0.0034752711313695	-5.66208277959337	36	13	0.00766509433962264	1696	10287	23586,7323,55593,1540,7128,6233,5300,84166,3661,57506,84282,5094,9636	DDX58,UBE2D3,OTUD5,CYLD,TNFAIP3,RPS27A,PIN1,NLRC5,IRF3,MAVS,RNF135,PCBP2,ISG15
R-HSA-429914	Deadenylation-dependent mRNA decay	0.00355643076577352	-5.63899783093548	57	18	0.0106132075471698	1696	10287	118460,5393,55571,5073,219988,10605,4849,80153,9125,23016,11157,9775,115024,51013,55802,57472,246175,26986	EXOSC6,EXOSC9,CNOT11,PARN,PATL1,PAIP1,CNOT3,EDC3,CNOT9,EXOSC7,LSM6,EIF4A3,NT5C3B,EXOSC1,DCP1A,CNOT6,CNOT6L,PABPC1
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	0.00380034380192856	-5.57266374215061	53	17	0.0100235849056604	1696	10287	6209,51386,6187,8664,6204,6229,8666,6203,3921,8667,8661,27335,8894,6233,6208,2197,6231	RPS15,EIF3L,RPS2,EIF3D,RPS10,RPS24,EIF3G,RPS9,RPSA,EIF3H,EIF3A,EIF3K,EIF2S2,RPS27A,RPS14,FAU,RPS26
R-HSA-168249	Innate Immune System	0.00385482972492528	-5.55842844287096	1285	246	0.145047169811321	1696	10287	51816,51552,7295,7249,102,4763,5589,3074,8454,387921,2992,1432,56888,54918,51728,329,805,5036,5906,5707,998,5296,8907,1785,5094,8514,64223,4893,4690,9978,208,23526,84418,7335,5869,7454,10555,6233,5714,3984,27297,51719,527,60,1191,6093,409,5700,8992,823,258010,23586,7323,80331,9535,5440,3133,7410,1660,8649,427,2683,4205,8621,4125,5532,5870,10787,5663,5715,374395,2799,966,4775,10092,829,23545,596,26578,84282,9961,79888,9114,23191,2512,8804,7867,79837,5682,79169,3845,830,5315,26999,3384,2002,10552,25852,5605,10694,5691,9636,5704,7520,55832,847,1445,1845,8773,47,5534,84166,5476,2821,391,10163,1540,5894,8655,6195,10096,5879,4627,56954,3661,598,526,5566,4067,8895,351,7409,533,4193,5687,6464,5300,115,25798,1027,57506,10768,1386,10006,64114,2760,1072,9550,113,22875,8904,10576,7077,330,5441,115004,143471,7879,10450,8452,5695,535,7456,4773,54472,5698,5515,221,5525,1650,79980,6836,3716,53917,23118,6778,5709,124583,148022,22954,8566,5536,4048,5594,203068,4282,55593,4126,11333,27161,8315,80143,84335,4650,2309,5305,3105,84513,23396,2261,5708,1520,156,5728,10075,10010,5781,1265,1385,9020,10695,9040,4644,818,6709,5170,5530,387,9761,7128,5591,5575,23593,84265,8772,4758,3304,5595,1514,3106,22931,23646,51382,51125,84061,9844,9342,84078,23220,10857,3614,5660,528,5223,3265,3428	ADA2,RAB14,TXN,TSC2,ADAM10,NF1,PRKCSH,HEXB,CUL1,NHLRC3,GYG1,MAPK14,KCMF1,CMTM6,POLR3K,BIRC2,CALM2,PA2G4,RAP1A,PSMD1,CDC42,PIK3R2,AP1M1,DNM2,PCBP2,KCNAB2,MLST8,NRAS,NCK1,RBX1,AKT2,ARHGAP45,CYSTM1,UBE2V1,RAB5B,WAS,AGPAT2,RPS27A,PSMD8,LIMK1,CRCP,CAB39,ATP6V0C,ACTB,CLU,ROCK1,ARRB2,PSMC1,ATP6V0E1,CAPN1,SVIP,DDX58,UBE2D3,DNAJC5,GMFG,POLR2K,HLA-E,VAV2,DHX9,LAMTOR3,ASAH1,B4GALT1,MEF2A,CDK13,MAN2B1,PPP3CB,RAB6A,NCKAP1,PSEN1,PSMD9,TMEM179B,GNS,CD59,NFATC3,ARPC5,CAPZA1,ATP6V0A2,BCL2,OSTF1,RNF135,MVP,LPCAT1,ATP6V0D1,CYFIP1,FTL,CREG1,MAPKAPK3,PIP4K2C,PSMA1,C1orf35,KRAS,CAPZA2,PKM,CYFIP2,ICAM2,ELK1,ARPC1A,ARMC8,MAP2K2,CCT8,PSMB3,ISG15,PSMC4,XRCC5,CAND1,CAT,CSK,DUSP3,SNAP23,ACLY,PPP3R1,NLRC5,CTSA,GPI,RHOG,WASF2,CYLD,RAF1,DYNLL1,RPS6KA1,ACTR3,RAC1,MYH9,NIT2,IRF3,BCL2L1,ATP6V1B2,PRKACA,LYN,CPNE3,APP,VAV1,ATP6V0B,MDM2,PSMA6,SHC1,PIN1,ADCY9,BRI3,CDKN1B,MAVS,AHCYL1,ATF2,ABI1,TMBIM1,GM2A,CFL1,ATP6V1G1,ADCY7,ENPP4,CPNE1,CCT2,TIMP2,BIRC3,POLR2L,CGAS,PSMA8,RAB7A,PPIE,CUL3,PSMB7,ATP6V0A1,WIPF1,NFATC2,TOLLIP,PSMB9,PPP2CA,ALDH3B1,PPP2R5A,DDOST,DSN1,SURF4,JAK1,RAB24,TAB2,STAT6,PSMD3,CANT1,TICAM1,TRIM32,PDXK,PPP5C,LTA4H,MAPK1,TUBB,MIF,OTUD5,MANBA,PDAP1,AGO2,BRAP,SIKE1,AKT1S1,MYO9B,FOXO3,PIP4K2A,HLA-A,PLPP5,PIP5K1C,FGFR3,PSMD2,CTSS,GRK2,PTEN,HUWE1,TANK,PTPN11,CNN2,CREB1,MAP3K14,CNPY3,UBE2M,MYO5A,CAMK2G,SPTAN1,PDPK1,PPP3CA,RHOA,MLEC,TNFAIP3,PRKDC,PRKAR1B,HEBP2,POLR3GL,FADD,NEU1,HSPA1B,MAPK3,CTSL,HLA-B,RAB18,PLD3,ATP6V1D,GOLGA7,MAGT1,ELMO1,SNAP29,KBTBD7,DTX4,PGRMC1,IMPDH1,PSAP,ATP6V1C1,PGAM1,HRAS,IFI16
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.00403554624886825	-5.51261360876044	49	16	0.00943396226415094	1696	10287	9648,22836,90196,60592,143187,9382,23647,10618,5870,8675,57589,8774,2803,4905,79571,60560	GCC2,RHOBTB3,SYS1,SCOC,VTI1A,COG1,ARFIP2,TGOLN2,RAB6A,STX16,RIC1,NAPG,GOLGA4,NSF,GCC1,NAA35
R-HSA-72649	Translation initiation complex formation	0.00405163931998966	-5.5086337093933	62	19	0.0112028301886792	1696	10287	6209,51386,6187,8664,6204,6229,7458,8666,6203,3921,8667,8661,27335,8894,6233,6208,2197,26986,6231	RPS15,EIF3L,RPS2,EIF3D,RPS10,RPS24,EIF4H,EIF3G,RPS9,RPSA,EIF3H,EIF3A,EIF3K,EIF2S2,RPS27A,RPS14,FAU,PABPC1,RPS26
R-HSA-72187	mRNA 3'-end processing	0.00405163931998966	-5.5086337093933	62	19	0.0112028301886792	1696	10287	9295,84248,51362,84324,9984,6431,9939,10921,6430,10212,8189,6426,10914,9775,6429,6428,26097,10898,1477	SRSF11,FYTTD1,CDC40,SARNP,THOC1,SRSF6,RBM8A,RNPS1,SRSF5,DDX39A,SYMPK,SRSF1,PAPOLA,EIF4A3,SRSF4,SRSF3,CHTOP,CPSF4,CSTF1
R-HSA-2559583	Cellular Senescence	0.00410648938936953	-5.49518677864965	196	47	0.0277122641509434	1696	10287	3015,7295,29855,6195,23512,1432,2113,1912,54386,1031,5925,4193,890,1027,51434,6774,7014,2077,7867,9448,79813,1871,29882,8697,94239,5595,8881,996,2114,6233,7027,3014,1869,23523,4217,7029,5928,3020,1017,1870,11065,5594,7013,25913,8535,29945,1029	H2AFZ,TXN,UBN1,RPS6KA1,SUZ12,MAPK14,ETS1,PHC2,TERF2IP,CDKN2C,RB1,MDM2,CCNA2,CDKN1B,ANAPC7,STAT3,TERF2,ERF,MAPKAPK3,MAP4K4,EHMT1,E2F3,ANAPC2,CDC23,H2AFV,MAPK3,CDC16,CDC27,ETS2,RPS27A,TFDP1,H2AFX,E2F1,CABIN1,MAP3K5,TFDP2,RBBP4,H3F3A,CDK2,E2F2,UBE2C,MAPK1,TERF1,POT1,CBX4,ANAPC4,CDKN2A
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.00432778295948252	-5.44269988668928	25	10	0.00589622641509434	1696	10287	5438,5436,5441,5439,54487,5440,27161,5433,8575,5430	POLR2I,POLR2G,POLR2L,POLR2J,DGCR8,POLR2K,AGO2,POLR2D,PRKRA,POLR2A
R-HSA-68689	CDC6 association with the ORC:origin complex	0.00433433609009054	-5.4411868315533	11	6	0.0035377358490566	1696	10287	990,4998,23595,1870,1869,1871	CDC6,ORC1,ORC3,E2F2,E2F1,E2F3
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.00433433609009054	-5.4411868315533	11	6	0.0035377358490566	1696	10287	1457,10592,891,64151,9133,10051	CSNK2A1,SMC2,CCNB1,NCAPG,CCNB2,SMC4
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.0044024559496295	-5.42559272340672	85	24	0.0141509433962264	1696	10287	10920,2067,5983,9978,51426,6613,9557,283899,7329,5982,6117,5886,6118,5111,5426,6233,5887,7507,60,64708,10980,7528,2966,1642	COPS8,ERCC1,RFC3,RBX1,POLK,SUMO2,CHD1L,INO80E,UBE2I,RFC2,RPA1,RAD23A,RPA2,PCNA,POLE,RPS27A,RAD23B,XPA,ACTB,COPS7B,COPS6,YY1,GTF2H2,DDB1
R-HSA-5696400	Dual Incision in GG-NER	0.00443391142605547	-5.41847314406885	41	14	0.00825471698113208	1696	10287	6118,2067,5111,5983,5426,9978,51426,6233,9557,7507,5982,2966,1642,6117	RPA2,ERCC1,PCNA,RFC3,POLE,RBX1,POLK,RPS27A,CHD1L,XPA,RFC2,GTF2H2,DDB1,RPA1
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.00447475642821936	-5.40930335818484	3	3	0.0017688679245283	1696	10287	7248,7249,208	TSC1,TSC2,AKT2
R-HSA-176187	Activation of ATR in response to replication stress	0.0045630908419642	-5.38975506884929	37	13	0.00766509433962264	1696	10287	6118,5983,55388,63967,4174,10926,990,4998,4171,23595,1017,5982,6117	RPA2,RFC3,MCM10,CLSPN,MCM5,DBF4,CDC6,ORC1,MCM2,ORC3,CDK2,RFC2,RPA1
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.00492370179831318	-5.31369463335629	63	19	0.0112028301886792	1696	10287	6209,51386,6187,8664,6204,6229,7458,8666,6203,3921,8667,8661,27335,8894,6233,6208,2197,26986,6231	RPS15,EIF3L,RPS2,EIF3D,RPS10,RPS24,EIF4H,EIF3G,RPS9,RPSA,EIF3H,EIF3A,EIF3K,EIF2S2,RPS27A,RPS14,FAU,PABPC1,RPS26
R-HSA-73893	DNA Damage Bypass	0.00504453065111593	-5.28945066198881	50	16	0.00943396226415094	1696	10287	5983,9978,51426,9100,5982,10459,55666,9636,6117,6118,51514,5111,56852,5426,6233,1642	RFC3,RBX1,POLK,USP10,RFC2,MAD2L2,NPLOC4,ISG15,RPA1,RPA2,DTL,PCNA,RAD18,POLE,RPS27A,DDB1
R-HSA-5632684	Hedgehog 'on' state	0.00517410440719988	-5.26408901621821	86	24	0.0141509433962264	1696	10287	25989,143471,9978,5695,8452,5682,1452,5715,5698,79577,5691,5704,132884,5708,5687,5707,156,6233,5714,5709,409,57154,5700,8650	ULK3,PSMA8,RBX1,PSMB7,CUL3,PSMA1,CSNK1A1,PSMD9,PSMB9,CDC73,PSMB3,PSMC4,EVC2,PSMD2,PSMA6,PSMD1,GRK2,RPS27A,PSMD8,PSMD3,ARRB2,SMURF1,PSMC1,NUMB
R-HSA-4641258	Degradation of DVL	0.00535024217907627	-5.23061345198169	59	18	0.0106132075471698	1696	10287	143471,9978,5695,8452,5682,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,1855,5700,1856	PSMA8,RBX1,PSMB7,CUL3,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,DVL1,PSMC1,DVL2
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.005461525708266	-5.21002709451131	91	25	0.0147405660377358	1696	10287	118460,143471,5695,5682,5393,5715,1432,5698,5073,5691,5704,5708,5707,5687,23016,6233,5714,5709,51013,55802,8125,8570,7534,5700,26986	EXOSC6,PSMA8,PSMB7,PSMA1,EXOSC9,PSMD9,MAPK14,PSMB9,PARN,PSMB3,PSMC4,PSMD2,PSMD1,PSMA6,EXOSC7,RPS27A,PSMD8,PSMD3,EXOSC1,DCP1A,ANP32A,KHSRP,YWHAZ,PSMC1,PABPC1
R-HSA-69273	Cyclin A/B1 associated events during G2/M transition	0.00564394628923739	-5.17717176147247	22	9	0.00530660377358491	1696	10287	5347,5515,890,2305,9088,994,891,1017,9133	PLK1,PPP2CA,CCNA2,FOXM1,PKMYT1,CDC25B,CCNB1,CDK2,CCNB2
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.00590871427252412	-5.13132702241217	38	13	0.00766509433962264	1696	10287	9150,5438,5439,5436,5441,5440,6924,5433,6917,5430,2962,11198,6749	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,POLR2A,GTF2F1,SUPT16H,SSRP1
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.00590871427252412	-5.13132702241217	38	13	0.00766509433962264	1696	10287	9150,5438,5439,5436,5441,5440,6924,5433,6917,5430,2962,11198,6749	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,POLR2A,GTF2F1,SUPT16H,SSRP1
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.00595187378000954	-5.12404918799181	101	27	0.0159198113207547	1696	10287	5170,5530,143471,5695,5682,8454,7335,4773,5532,5715,5698,5691,5704,805,5708,4775,5687,5707,6233,23118,5714,5709,5534,9020,10768,5700,9040	PDPK1,PPP3CA,PSMA8,PSMB7,PSMA1,CUL1,UBE2V1,NFATC2,PPP3CB,PSMD9,PSMB9,PSMB3,PSMC4,CALM2,PSMD2,NFATC3,PSMA6,PSMD1,RPS27A,TAB2,PSMD8,PSMD3,PPP3R1,MAP3K14,AHCYL1,PSMC1,UBE2M
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.00613081351191421	-5.09442782790214	30	11	0.00648584905660377	1696	10287	51514,6118,5111,5983,5426,56852,9978,6233,5982,1642,6117	DTL,RPA2,PCNA,RFC3,POLE,RAD18,RBX1,RPS27A,RFC2,DDB1,RPA1
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.00613081351191421	-5.09442782790214	30	11	0.00648584905660377	1696	10287	805,7409,5530,4775,6464,7410,5534,4773,5532,10768,4067	CALM2,VAV1,PPP3CA,NFATC3,SHC1,VAV2,PPP3R1,NFATC2,PPP3CB,AHCYL1,LYN
R-HSA-917977	Transferrin endocytosis and recycling	0.00613081351191421	-5.09442782790214	30	11	0.00648584905660377	1696	10287	533,51382,535,23545,527,526,528,8992,9114,7037,9550	ATP6V0B,ATP6V1D,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1B2,ATP6V1C1,ATP6V0E1,ATP6V0D1,TFRC,ATP6V1G1
R-HSA-975577	N-Glycan antennae elongation	0.00617089653432092	-5.08791114622017	15	7	0.00412735849056604	1696	10287	2683,8703,8702,8128,9334,4249,8704	B4GALT1,B4GALT3,B4GALT4,ST8SIA2,B4GALT5,MGAT5,B4GALT2
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	0.00649157954827677	-5.03724939601787	60	18	0.0106132075471698	1696	10287	5708,5707,5687,143471,6233,5714,5709,81620,5695,5682,990,4998,23595,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,CDT1,PSMB7,PSMA1,CDC6,ORC1,ORC3,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.00705577945582129	-4.95390821702729	88	24	0.0141509433962264	1696	10287	9150,5438,5436,5441,5440,6924,5433,23168,55840,79577,5430,2962,55677,11198,6873,8812,54623,5439,9646,6917,6883,6878,2966,6749	CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,RTF1,EAF2,CDC73,POLR2A,GTF2F1,IWS1,SUPT16H,TAF2,CCNK,PAF1,POLR2J,CTR9,TCEA1,TAF12,TAF6,GTF2H2,SSRP1
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	0.00707056323735923	-4.95181513642514	56	17	0.0100235849056604	1696	10287	143471,9978,5695,5682,8454,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,23194,5700	PSMA8,RBX1,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,FBXL7,PSMC1
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.00713139902754486	-4.94324784675702	65	19	0.0112028301886792	1696	10287	143471,5695,5682,5698,5715,5691,5704,5708,5687,890,5707,4193,6233,5709,5714,1027,11200,1017,5700	PSMA8,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,PSMD1,MDM2,RPS27A,PSMD3,PSMD8,CDKN1B,CHEK2,CDK2,PSMC1
R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.00713139902754486	-4.94324784675702	65	19	0.0112028301886792	1696	10287	143471,5695,5682,5698,5715,5691,5704,5708,5687,890,5707,4193,6233,5709,5714,1027,11200,1017,5700	PSMA8,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,PSMD1,MDM2,RPS27A,PSMD3,PSMD8,CDKN1B,CHEK2,CDK2,PSMC1
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.0073251846038758	-4.91643692250226	19	8	0.00471698113207547	1696	10287	5438,5436,5441,5439,5440,5430,2962,5433	POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2A,GTF2F1,POLR2D
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	0.0073251846038758	-4.91643692250226	19	8	0.00471698113207547	1696	10287	118460,23016,51013,8570,7534,5393,5073,1432	EXOSC6,EXOSC7,EXOSC1,KHSRP,YWHAZ,EXOSC9,PARN,MAPK14
R-HSA-5223345	Miscellaneous transport and binding events	0.0073251846038758	-4.91643692250226	19	8	0.00471698113207547	1696	10287	57185,120,118,84061,56172,57380,81614,123606	NIPAL3,ADD3,ADD1,MAGT1,ANKH,MRS2,NIPA2,NIPA1
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.00767612224774459	-4.86964077499365	52	16	0.00943396226415094	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,990,1017,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CDC6,CDK2,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	0.00782284264402637	-4.85070728101219	61	18	0.0106132075471698	1696	10287	143471,9978,5695,5682,8454,1452,5566,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,5700	PSMA8,RBX1,PSMB7,PSMA1,CUL1,CSNK1A1,PRKACA,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,PSMC1
R-HSA-5610780	Degradation of GLI1 by the proteasome	0.00782284264402637	-4.85070728101219	61	18	0.0106132075471698	1696	10287	143471,9978,5695,5682,8454,5566,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,5700,8650	PSMA8,RBX1,PSMB7,PSMA1,CUL1,PRKACA,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,PSMC1,NUMB
R-HSA-5610783	Degradation of GLI2 by the proteasome	0.00782284264402637	-4.85070728101219	61	18	0.0106132075471698	1696	10287	143471,9978,5695,5682,8454,1452,5566,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,5700	PSMA8,RBX1,PSMB7,PSMA1,CUL1,CSNK1A1,PRKACA,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,PSMC1
R-HSA-6804757	Regulation of TP53 Degradation	0.0078898553963177	-4.84217747175521	35	12	0.00707547169811321	1696	10287	5170,5515,7874,4193,890,6233,208,117584,11200,1017,1029,64223	PDPK1,PPP2CA,USP7,MDM2,CCNA2,RPS27A,AKT2,RFFL,CHEK2,CDK2,CDKN2A,MLST8
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.00793741952211186	-4.83616705376126	23	9	0.00530660377358491	1696	10287	8881,996,6233,29882,51434,891,8697,11065,29945	CDC16,CDC27,RPS27A,ANAPC2,ANAPC7,CCNB1,CDC23,UBE2C,ANAPC4
R-HSA-77387	Insulin receptor recycling	0.00815961390249608	-4.80855842699613	27	10	0.00589622641509434	1696	10287	533,51382,535,23545,527,526,528,8992,9114,9550	ATP6V0B,ATP6V1D,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1B2,ATP6V1C1,ATP6V0E1,ATP6V0D1,ATP6V1G1
R-HSA-5654738	Signaling by FGFR2	0.00823372450278915	-4.79951681468468	75	21	0.0123820754716981	1696	10287	5438,4893,5436,5441,5440,5433,3185,7072,3845,5430,5595,2962,5515,8569,6464,5439,6233,5781,5594,3265,4670	POLR2I,NRAS,POLR2G,POLR2L,POLR2K,POLR2D,HNRNPF,TIA1,KRAS,POLR2A,MAPK3,GTF2F1,PPP2CA,MKNK1,SHC1,POLR2J,RPS27A,PTPN11,MAPK1,HRAS,HNRNPM
R-HSA-6802957	Oncogenic MAPK signaling	0.00823372450278915	-4.79951681468468	75	21	0.0123820754716981	1696	10287	55109,4893,57085,4763,5894,22906,8315,3845,27044,8087,23499,5605,4000,5595,5906,1445,1185,5594,409,3265,56829	AGGF1,NRAS,AGTRAP,NF1,RAF1,TRAK1,BRAP,KRAS,SND1,FXR1,MACF1,MAP2K2,LMNA,MAPK3,RAP1A,CSK,CLCN6,MAPK1,ARRB2,HRAS,ZC3HAV1
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.00834009370665564	-4.78668082686457	6	4	0.00235849056603774	1696	10287	5594,5605,5894,5595	MAPK1,MAP2K2,RAF1,MAPK3
R-HSA-112411	MAPK1 (ERK2) activation	0.0085062054886592	-4.76695932435889	9	5	0.00294811320754717	1696	10287	3716,5594,5605,3572,5781	JAK1,MAPK1,MAP2K2,IL6ST,PTPN11
R-HSA-5358351	Signaling by Hedgehog	0.00872483684850166	-4.74158151038061	138	34	0.0200471698113208	1696	10287	8454,1452,5566,5715,79577,5708,5707,5687,156,115,113,25989,6868,9978,143471,5575,8452,5695,5682,84447,5698,5691,132884,5704,2778,6233,7289,5709,5714,6400,57154,409,5700,8650	CUL1,CSNK1A1,PRKACA,PSMD9,CDC73,PSMD2,PSMD1,PSMA6,GRK2,ADCY9,ADCY7,ULK3,ADAM17,RBX1,PSMA8,PRKAR1B,CUL3,PSMB7,PSMA1,SYVN1,PSMB9,PSMB3,EVC2,PSMC4,GNAS,RPS27A,TULP3,PSMD3,PSMD8,SEL1L,SMURF1,ARRB2,PSMC1,NUMB
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.00892686610099903	-4.71868988622539	44	14	0.00825471698113208	1696	10287	578,208,8655,7027,331,1869,5534,54205,7534,596,598,7159,7029,7533	BAK1,AKT2,DYNLL1,TFDP1,XIAP,E2F1,PPP3R1,CYCS,YWHAZ,BCL2,BCL2L1,TP53BP2,TFDP2,YWHAH
R-HSA-1236974	ER-Phagosome pathway	0.00910798946133192	-4.69860328785949	85	23	0.013561320754717	1696	10287	10952,143471,23480,3133,6890,5695,5682,5698,5715,5691,3105,5704,3106,5708,5687,5707,29927,6233,5714,8773,5709,6891,5700	SEC61B,PSMA8,SEC61G,HLA-E,TAP1,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,HLA-A,PSMC4,HLA-B,PSMD2,PSMA6,PSMD1,SEC61A1,RPS27A,PSMD8,SNAP23,PSMD3,TAP2,PSMC1
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.00911366830587942	-4.69797998071545	71	20	0.0117924528301887	1696	10287	4149,5695,5682,8454,5698,5715,5691,5704,5708,5925,5687,890,5707,6233,5709,5714,1027,994,1017,5700	MAX,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,RB1,PSMA6,CCNA2,PSMD1,RPS27A,PSMD3,PSMD8,CDKN1B,CDC25B,CDK2,PSMC1
R-HSA-5678895	Defective CFTR causes cystic fibrosis	0.00936560764032044	-4.67071106101367	62	18	0.0106132075471698	1696	10287	143471,10613,5695,5682,5698,5715,5691,5704,79139,5708,5687,5707,6233,5709,5714,6400,5700,6048	PSMA8,ERLIN1,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,DERL1,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1,RNF5
R-HSA-110312	Translesion synthesis by REV1	0.00942943236928322	-4.66391937828603	16	7	0.00412735849056604	1696	10287	6118,5111,5983,5982,6233,10459,6117	RPA2,PCNA,RFC3,RFC2,RPS27A,MAD2L2,RPA1
R-HSA-1834941	STING mediated induction of host immune responses	0.00942943236928322	-4.66391937828603	16	7	0.00412735849056604	1696	10287	3661,115004,6778,5591,3428,7520,23220	IRF3,CGAS,STAT6,PRKDC,IFI16,XRCC5,DTX4
R-HSA-69615	G1/S DNA Damage Checkpoints	0.0100811391756851	-4.59708900926363	67	19	0.0112028301886792	1696	10287	143471,5695,5682,5698,5715,5691,5704,5708,5687,890,5707,4193,6233,5709,5714,1027,11200,1017,5700	PSMA8,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,PSMD1,MDM2,RPS27A,PSMD3,PSMD8,CDKN1B,CHEK2,CDK2,PSMC1
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.0100971475288727	-4.59550231790767	36	12	0.00707547169811321	1696	10287	5170,5515,7874,4193,890,6233,208,117584,11200,1017,1029,64223	PDPK1,PPP2CA,USP7,MDM2,CCNA2,RPS27A,AKT2,RFFL,CHEK2,CDK2,CDKN2A,MLST8
R-HSA-69186	Lagging Strand Synthesis	0.010472872783793	-4.55896690932945	20	8	0.00471698113207547	1696	10287	23649,6118,5111,5983,5558,5982,5557,6117	POLA2,RPA2,PCNA,RFC3,PRIM2,RFC2,PRIM1,RPA1
R-HSA-69202	Cyclin E associated events during G1/S transition	0.01071349727225	-4.53625090513219	72	20	0.0117924528301887	1696	10287	4149,208,5695,5682,8454,5698,5715,5691,5704,5708,5925,5687,890,5707,6233,5709,5714,1027,1017,5700	MAX,AKT2,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,RB1,PSMA6,CCNA2,PSMD1,RPS27A,PSMD3,PSMD8,CDKN1B,CDK2,PSMC1
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	0.0108544201072701	-4.52318289879512	28	10	0.00589622641509434	1696	10287	27243,9146,29082,6233,128866,27183,25978,91782,84313,8027	CHMP2A,HGS,CHMP4A,RPS27A,CHMP4B,VPS4A,CHMP2B,CHMP7,VPS25,STAM
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.0108760773429366	-4.52118964089695	24	9	0.00530660377358491	1696	10287	23649,6118,5111,5983,5426,5558,5982,5557,6117	POLA2,RPA2,PCNA,RFC3,POLE,PRIM2,RFC2,PRIM1,RPA1
R-HSA-6811438	Intra-Golgi traffic	0.0110383027047025	-4.50638399046855	45	14	0.00825471698113208	1696	10287	4122,8774,9267,27333,4905,9342,11311,143187,9382,375,8675,9527,57589,4121	MAN2A2,NAPG,CYTH1,GOLIM4,NSF,SNAP29,VPS45,VTI1A,COG1,ARF1,STX16,GOSR1,RIC1,MAN1A1
R-HSA-4086400	PCP/CE pathway	0.0112037890200523	-4.49150325253163	96	25	0.0147405660377358	1696	10287	387,143471,5879,5695,5682,5715,5698,5691,8323,5704,5708,5687,5707,6233,5714,81029,5709,163,1855,1212,409,57154,5700,1175,1856	RHOA,PSMA8,RAC1,PSMB7,PSMA1,PSMD9,PSMB9,PSMB3,FZD6,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD8,WNT5B,PSMD3,AP2B1,DVL1,CLTB,ARRB2,SMURF1,PSMC1,AP2S1,DVL2
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0112669427616859	-4.48588225998644	77	21	0.0123820754716981	1696	10287	7040,7323,892,9612,387,4221,8812,2280,4087,6233,9110,5933,51377,1874,7027,7029,57154,4089,9040,11171,56288	TGFB1,UBE2D3,CCNC,NCOR2,RHOA,MEN1,CCNK,FKBP1A,SMAD2,RPS27A,MTMR4,RBL1,UCHL5,E2F4,TFDP1,TFDP2,SMURF1,SMAD4,UBE2M,STRAP,PARD3
R-HSA-189200	Hexose transport	0.0113059939460948	-4.48242225618869	54	16	0.00943396226415094	1696	10287	55706,23511,8480,6513,53371,9631,55974,23165,23225,57122,9972,23636,79902,9818,81929,8086	NDC1,NUP188,RAE1,SLC2A1,NUP54,NUP155,SLC50A1,NUP205,NUP210,NUP107,NUP153,NUP62,NUP85,NUP58,SEH1L,AAAS
R-HSA-1236975	Antigen processing-Cross presentation	0.0114580150464498	-4.4690657898137	101	26	0.0153301886792453	1696	10287	10952,143471,23480,3133,6890,5695,5682,5715,5698,3693,5691,3105,5704,1514,3106,5708,5687,1520,5707,29927,6233,5714,8773,5709,6891,5700	SEC61B,PSMA8,SEC61G,HLA-E,TAP1,PSMB7,PSMA1,PSMD9,PSMB9,ITGB5,PSMB3,HLA-A,PSMC4,CTSL,HLA-B,PSMD2,PSMA6,CTSS,PSMD1,SEC61A1,RPS27A,PSMD8,SNAP23,PSMD3,TAP2,PSMC1
R-HSA-373755	Semaphorin interactions	0.0118840557932431	-4.43255762657261	68	19	0.0112028301886792	1696	10287	391,387,10154,389,5879,4627,23365,5361,388,23396,1809,1020,998,1808,3984,3688,6093,103910,1072	RHOG,RHOA,PLXNC1,RHOC,RAC1,MYH9,ARHGEF12,PLXNA1,RHOB,PIP5K1C,DPYSL3,CDK5,CDC42,DPYSL2,LIMK1,ITGB1,ROCK1,MYL12B,CFL1
R-HSA-171007	p38MAPK events	0.0119586351759364	-4.42630165269573	13	6	0.0035377358490566	1696	10287	3845,4893,5899,7867,1432,3265	KRAS,NRAS,RALB,MAPKAPK3,MAPK14,HRAS
R-HSA-382556	ABC-family proteins mediated transport	0.0132222136852149	-4.32585700886305	107	27	0.0159198113207547	1696	10287	21,143471,10613,89845,5695,5682,23456,5715,5698,23,5691,5704,79139,5708,5707,5687,8894,6233,5714,5709,6400,215,6041,5700,6048,4363,10057	ABCA3,PSMA8,ERLIN1,ABCC10,PSMB7,PSMA1,ABCB10,PSMD9,PSMB9,ABCF1,PSMB3,PSMC4,DERL1,PSMD2,PSMD1,PSMA6,EIF2S2,RPS27A,PSMD8,PSMD3,SEL1L,ABCD1,RNASEL,PSMC1,RNF5,ABCC1,ABCC5
R-HSA-5656121	Translesion synthesis by POLI	0.0137857372336644	-4.28412075507575	17	7	0.00412735849056604	1696	10287	6118,5111,5983,5982,6233,10459,6117	RPA2,PCNA,RFC3,RFC2,RPS27A,MAD2L2,RPA1
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.0141730571991764	-4.25641249702082	29	10	0.00589622641509434	1696	10287	9844,5879,8907,1174,163,55690,375,162,1175,3105	ELMO1,RAC1,AP1M1,AP1S1,AP2B1,PACS1,ARF1,AP1B1,AP2S1,HLA-A
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.0145192973846415	-4.23227666024379	21	8	0.00471698113207547	1696	10287	9125,1263,55835,7832,57472,246175,55571,4849	CNOT9,PLK3,CENPJ,BTG2,CNOT6,CNOT6L,CNOT11,CNOT3
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.0145594929339101	-4.22951206278775	25	9	0.00530660377358491	1696	10287	5170,4193,7249,208,1027,84335,1385,2309,64223	PDPK1,MDM2,TSC2,AKT2,CDKN1B,AKT1S1,CREB1,FOXO3,MLST8
R-HSA-429947	Deadenylation of mRNA	0.0145594929339101	-4.22951206278775	25	9	0.00530660377358491	1696	10287	9125,9775,57472,246175,5073,55571,26986,4849,10605	CNOT9,EIF4A3,CNOT6,CNOT6L,PARN,CNOT11,PABPC1,CNOT3,PAIP1
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.0145594929339101	-4.22951206278775	25	9	0.00530660377358491	1696	10287	5515,4205,1385,2002,1845,5594,1432,6195,5595	PPP2CA,MEF2A,CREB1,ELK1,DUSP3,MAPK1,MAPK14,RPS6KA1,MAPK3
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.0145594929339101	-4.22951206278775	25	9	0.00530660377358491	1696	10287	9150,5438,5439,5436,5441,5440,5433,5430,2962	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,POLR2A,GTF2F1
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	0.014600470363849	-4.22670153408481	60	17	0.0100235849056604	1696	10287	143471,5695,5682,8454,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,9020,9040,5700	PSMA8,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,MAP3K14,UBE2M,PSMC1
R-HSA-3928662	EPHB-mediated forward signaling	0.0147053574237137	-4.21954340100066	42	13	0.00766509433962264	1696	10287	387,998,10092,3984,10096,5879,6383,60,6093,10552,4067,3265,1072	RHOA,CDC42,ARPC5,LIMK1,ACTR3,RAC1,SDC2,ACTB,ROCK1,ARPC1A,LYN,HRAS,CFL1
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.0147243783400599	-4.21825076832823	10	5	0.00294811320754717	1696	10287	5515,891,55844,84930,2029	PPP2CA,CCNB1,PPP2R2D,MASTL,ENSA
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.0147243783400599	-4.21825076832823	10	5	0.00294811320754717	1696	10287	1174,55690,162,3105,8907	AP1S1,PACS1,AP1B1,HLA-A,AP1M1
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.0159749173005894	-4.13673545553386	89	23	0.013561320754717	1696	10287	51552,80006,84079,83696,208,55667,163486,7879,51622,22879,5870,117177,5861,5869,57589,23011,4218,22931,126432,11021,221960,5866,57679	RAB14,TRAPPC13,ANKRD27,TRAPPC9,AKT2,DENND4C,DENND1B,RAB7A,CCZ1,MON1B,RAB6A,RAB3IP,RAB1A,RAB5B,RIC1,RAB21,RAB8A,RAB18,RINL,RAB35,CCZ1B,RAB3IL1,ALS2
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	0.0161658388085269	-4.12485497873795	56	16	0.00943396226415094	1696	10287	143471,5695,5682,8454,5698,5715,5691,5704,26271,5708,5687,5707,6233,5709,5714,5700	PSMA8,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,FBXO5,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,PSMC1
R-HSA-4641257	Degradation of AXIN	0.0161658388085269	-4.12485497873795	56	16	0.00943396226415094	1696	10287	5708,5707,5687,143471,6233,5714,5709,8312,5695,8313,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,AXIN1,PSMB7,AXIN2,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-69541	Stabilization of p53	0.0161658388085269	-4.12485497873795	56	16	0.00943396226415094	1696	10287	5708,4193,5707,5687,143471,6233,5714,5709,5695,5682,11200,5698,5715,5700,5691,5704	PSMD2,MDM2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CHEK2,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-937061	TRIF-mediated TLR3/TLR4 signaling	0.016521419764005	-4.10309757245106	99	25	0.0147405660377358	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1845,6233,23118,10010,5781,148022,1385,1386,5594	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,DUSP3,RPS27A,TAB2,TANK,PTPN11,TICAM1,CREB1,ATF2,MAPK1
R-HSA-166166	MyD88-independent TLR3/TLR4 cascade	0.016521419764005	-4.10309757245106	99	25	0.0147405660377358	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1845,6233,23118,10010,5781,148022,1385,1386,5594	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,DUSP3,RPS27A,TAB2,TANK,PTPN11,TICAM1,CREB1,ATF2,MAPK1
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.016521419764005	-4.10309757245106	99	25	0.0147405660377358	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1845,6233,23118,10010,5781,148022,1385,1386,5594	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,DUSP3,RPS27A,TAB2,TANK,PTPN11,TICAM1,CREB1,ATF2,MAPK1
R-HSA-5621481	C-type lectin receptors (CLRs)	0.0166517053513048	-4.09524264429882	144	34	0.0200471698113208	1696	10287	5894,8454,5532,5566,5715,4067,805,5708,4775,5707,5687,9020,10768,9040,5170,5530,4893,143471,5695,5682,4773,7335,3845,3384,5698,5691,5704,23118,6233,5709,5714,5534,3265,5700	RAF1,CUL1,PPP3CB,PRKACA,PSMD9,LYN,CALM2,PSMD2,NFATC3,PSMD1,PSMA6,MAP3K14,AHCYL1,UBE2M,PDPK1,PPP3CA,NRAS,PSMA8,PSMB7,PSMA1,NFATC2,UBE2V1,KRAS,ICAM2,PSMB9,PSMB3,PSMC4,TAB2,RPS27A,PSMD3,PSMD8,PPP3R1,HRAS,PSMC1
R-HSA-8854518	AURKA Activation by TPX2	0.0168921808151338	-4.08090443778032	75	20	0.0117924528301887	1696	10287	5347,11116,22919,8655,10540,22974,54930,5566,55142,93323,5108,9738,55835,4957,8636,80254,54820,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,DYNLL1,DCTN2,TPX2,HAUS4,PRKACA,HAUS2,HAUS8,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,TUBB,CSNK1D,DCTN1
R-HSA-71387	Metabolism of carbohydrates	0.0168938253774591	-4.0808070860947	296	63	0.0371462264150943	1696	10287	2584,55706,23511,7360,375790,10007,4126,9334,8480,4191,6513,3074,7086,6383,53371,8604,2683,83440,4125,2992,347734,8702,5566,2132,23165,7957,2799,805,23225,2806,57122,231,9972,1836,6888,5261,79902,81929,6576,10057,11261,126792,5209,9631,5315,55974,5515,6448,6233,5634,4669,23636,4190,6483,2821,8703,3073,5223,54480,9818,5214,8086,8704	GALK1,NDC1,NUP188,UGP2,AGRN,GNPDA1,MANBA,B4GALT5,RAE1,MDH2,SLC2A1,HEXB,TKT,SDC2,NUP54,SLC25A12,B4GALT1,ADPGK,MAN2B1,GYG1,SLC35B2,B4GALT4,PRKACA,EXT2,NUP205,EPM2A,GNS,CALM2,NUP210,GOT2,NUP107,AKR1B1,NUP153,SLC26A2,TALDO1,PHKG2,NUP85,SEH1L,SLC25A1,ABCC5,CHP1,B3GALT6,PFKFB3,NUP155,PKM,SLC50A1,PPP2CA,SGSH,RPS27A,PRPS2,NAGLU,NUP62,MDH1,ST3GAL2,GPI,B4GALT3,HEXA,PGAM1,CHPF2,NUP58,PFKP,AAAS,B4GALT2
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.0172190992558378	-4.06173608937402	61	17	0.0100235849056604	1696	10287	5695,5682,8454,5698,5715,5691,5704,5708,5687,890,5707,6233,5709,5714,1027,1017,5700	PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,CCNA2,PSMD1,RPS27A,PSMD3,PSMD8,CDKN1B,CDK2,PSMC1
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	0.0172190992558378	-4.06173608937402	61	17	0.0100235849056604	1696	10287	143471,5695,5682,8454,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,9020,9040,5700	PSMA8,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,MAP3K14,UBE2M,PSMC1
R-HSA-168256	Immune System	0.0177732903702654	-4.03005848961955	2101	379	0.223466981132075	1696	10287	51552,7295,23511,7249,102,5589,3074,6890,8454,387921,2992,54918,51728,26263,805,5036,5707,8907,1785,26190,163,9972,8514,5094,81929,64223,80228,4893,208,23526,56992,4170,899,7454,6233,5714,3984,7174,3688,527,6041,57542,26224,409,8086,258010,23586,80331,9535,5440,23480,3133,7410,1660,9493,2683,4125,5663,5715,3693,374395,2799,966,51320,51088,223082,10092,25793,23545,26578,23194,84282,9961,79888,79902,9655,23191,2512,7867,79837,79169,830,5315,26999,2002,5605,10694,5691,7520,22872,847,3836,1845,1445,47,5534,2821,9604,9818,391,90933,55706,23304,6195,5894,10096,5879,4627,56954,598,162,5566,8895,351,1399,6464,6672,6477,115,79876,57122,1027,25798,6891,51434,57506,25897,1386,64114,1072,1639,9550,113,8904,22875,10576,10952,5441,8452,535,8697,79754,5698,5515,3796,221,8881,5525,29927,79980,1650,3716,53917,6772,148022,22954,8566,5536,1783,203068,55593,4126,8315,11119,80143,84335,51447,9354,2309,3105,84513,23396,5708,5728,10075,5781,26046,1265,89910,9020,1385,54620,10695,9040,6709,5170,5530,7128,26268,23593,29882,3832,8772,23014,23646,9817,81930,84061,5371,5660,975,29945,142678,51816,7325,4763,81559,55585,65264,11004,1432,56888,329,5906,23225,998,9775,3572,5296,200081,3835,140459,9830,81603,9978,4690,7428,84418,7335,3594,5869,89122,10555,54014,27297,51719,60,3838,1191,6093,5700,8992,823,7323,8649,427,3831,4205,29127,8621,5532,10787,5870,23165,4775,7408,92912,829,84876,22920,596,9690,90678,9114,8804,5682,3845,3384,10552,1982,25852,9636,3663,5704,55832,996,8773,6478,84166,23636,7534,5476,55905,154881,10163,1540,84231,8655,6597,3661,526,4067,7409,533,4193,5687,5300,10768,10006,2760,51132,7077,330,115004,143471,7879,64320,10450,5695,7456,4773,9631,54472,53339,6836,23118,6778,5709,124583,1174,4048,5594,57154,1175,4282,9371,9320,9903,8480,11333,10540,27161,53371,4650,375,5305,5771,3799,8916,3662,2261,1520,156,27252,9632,10010,6774,818,4644,7040,6868,9761,387,5591,5575,84265,4758,5595,3304,1514,3106,22931,150726,3840,51382,7726,51125,332,9844,9342,84078,10857,23220,3614,528,11065,5223,3265,3428	RAB14,TXN,NUP188,TSC2,ADAM10,PRKCSH,HEXB,TAP1,CUL1,NHLRC3,GYG1,CMTM6,POLR3K,FBXO22,CALM2,PA2G4,PSMD1,AP1M1,DNM2,FBXW2,AP2B1,NUP153,KCNAB2,PCBP2,SEH1L,MLST8,ORAI2,NRAS,AKT2,ARHGAP45,KIF15,MCL1,CCNF,WAS,RPS27A,PSMD8,LIMK1,TPP2,ITGB1,ATP6V0C,RNASEL,KLHL42,FBXL3,ARRB2,AAAS,SVIP,DDX58,DNAJC5,GMFG,POLR2K,SEC61G,HLA-E,VAV2,DHX9,KIF23,B4GALT1,MAN2B1,PSEN1,PSMD9,ITGB5,TMEM179B,GNS,CD59,MEX3C,KLHL5,ZNRF2,ARPC5,FBXO7,ATP6V0A2,OSTF1,FBXL7,RNF135,MVP,LPCAT1,NUP85,SOCS5,CYFIP1,FTL,MAPKAPK3,PIP4K2C,C1orf35,CAPZA2,PKM,CYFIP2,ELK1,MAP2K2,CCT8,PSMB3,XRCC5,SEC31A,CAT,KPNA1,DUSP3,CSK,ACLY,PPP3R1,GPI,RNF14,NUP58,RHOG,TRIM41,NDC1,UBR2,RPS6KA1,RAF1,ACTR3,RAC1,MYH9,NIT2,BCL2L1,AP1B1,PRKACA,CPNE3,APP,CRKL,SHC1,SP100,SIAH1,ADCY9,UBA5,NUP107,CDKN1B,BRI3,TAP2,ANAPC7,MAVS,RNF19A,ATF2,TMBIM1,CFL1,DCTN1,ATP6V1G1,ADCY7,CPNE1,ENPP4,CCT2,SEC61B,POLR2L,CUL3,ATP6V0A1,CDC23,ASB13,PSMB9,PPP2CA,KIF2A,ALDH3B1,CDC16,PPP2R5A,SEC61A1,DSN1,DDOST,JAK1,RAB24,STAT1,TICAM1,TRIM32,PDXK,PPP5C,DYNC1LI2,TUBB,OTUD5,MANBA,BRAP,BTN3A1,SIKE1,AKT1S1,IP6K2,UBE4A,FOXO3,HLA-A,PLPP5,PIP5K1C,PSMD2,PTEN,HUWE1,PTPN11,LTN1,CNN2,UBE3B,MAP3K14,CREB1,FBXL19,CNPY3,UBE2M,SPTAN1,PDPK1,PPP3CA,TNFAIP3,FBXO9,HEBP2,ANAPC2,KIF11,FADD,FBXO21,PLD3,KEAP1,KIF18A,MAGT1,PML,PSAP,CD81,ANAPC4,MIB2,ADA2,UBE2E2,NF1,TRIM11,UBE2Q1,UBE2Z,KIF2C,MAPK14,KCMF1,BIRC2,RAP1A,NUP210,CDC42,EIF4A3,IL6ST,PIK3R2,TXLNA,KIF22,ASB6,TRIM14,TRIM8,RBX1,NCK1,VHL,CYSTM1,UBE2V1,IL12RB1,RAB5B,TRIM4,AGPAT2,BRWD1,CRCP,CAB39,ACTB,KPNA2,CLU,ROCK1,PSMC1,ATP6V0E1,CAPN1,UBE2D3,LAMTOR3,ASAH1,KLC1,MEF2A,RACGAP1,CDK13,PPP3CB,NCKAP1,RAB6A,NUP205,NFATC3,VASP,UBE2Q2,CAPZA1,ORAI1,KIFAP3,BCL2,UBE3C,LRSAM1,ATP6V0D1,CREG1,PSMA1,KRAS,ICAM2,ARPC1A,EIF4G2,ARMC8,ISG15,IRF5,PSMC4,CAND1,CDC27,SNAP23,SIAH2,NLRC5,NUP62,YWHAZ,CTSA,RNF114,KCTD7,WASF2,CYLD,TRAF7,DYNLL1,SMARCA4,IRF3,ATP6V1B2,LYN,VAV1,ATP6V0B,MDM2,PSMA6,PIN1,AHCYL1,ABI1,GM2A,RLIM,TIMP2,BIRC3,CGAS,PSMA8,RAB7A,RNF25,PPIE,PSMB7,WIPF1,NFATC2,NUP155,TOLLIP,BTBD1,SURF4,TAB2,STAT6,PSMD3,CANT1,AP1S1,LTA4H,MAPK1,SMURF1,AP2S1,MIF,KIF3B,TRIP12,KLHL21,RAE1,PDAP1,DCTN2,AGO2,NUP54,MYO9B,ARF1,PIP4K2A,PTPN2,KIF5B,HERC3,IRF4,FGFR3,CTSS,GRK2,KLHL20,SEC24C,TANK,STAT3,CAMK2G,MYO5A,TGFB1,ADAM17,MLEC,RHOA,PRKDC,PRKAR1B,POLR3GL,NEU1,MAPK3,HSPA1B,CTSL,HLA-B,RAB18,FBXO41,KPNA4,ATP6V1D,TRIM26,GOLGA7,BIRC5,ELMO1,SNAP29,KBTBD7,PGRMC1,DTX4,IMPDH1,ATP6V1C1,UBE2C,PGAM1,HRAS,IFI16
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.0178807539548639	-4.02403034262781	52	15	0.00884433962264151	1696	10287	8812,9150,5438,5439,5436,5441,5440,6924,5433,6917,2966,5430,2962,6749,11198	CCNK,CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,GTF2H2,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.0179806499160258	-4.01845910398316	43	13	0.00766509433962264	1696	10287	6118,2067,9978,6233,6613,9557,7507,5887,7329,2966,1642,6117,5886	RPA2,ERCC1,RBX1,RPS27A,SUMO2,CHD1L,XPA,RAD23B,UBE2I,GTF2H2,DDB1,RPA1,RAD23A
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	6118,5111,2956,6117,5395,4436	RPA2,PCNA,MSH6,RPA1,PMS2,MSH2
R-HSA-69166	Removal of the Flap Intermediate	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	23649,6118,5111,5558,6117,5557	POLA2,RPA2,PCNA,PRIM2,RPA1,PRIM1
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	23649,5111,5983,5558,5982,5557	POLA2,PCNA,RFC3,PRIM2,RFC2,PRIM1
R-HSA-5675482	Regulation of necroptotic cell death	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	330,329,8772,8837,331,355	BIRC3,BIRC2,FADD,CFLAR,XIAP,FAS
R-HSA-69091	Polymerase switching	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	23649,5111,5983,5558,5982,5557	POLA2,PCNA,RFC3,PRIM2,RFC2,PRIM1
R-HSA-69109	Leading Strand Synthesis	0.018054333255491	-4.01436955345904	14	6	0.0035377358490566	1696	10287	23649,5111,5983,5558,5982,5557	POLA2,PCNA,RFC3,PRIM2,RFC2,PRIM1
R-HSA-428157	Sphingolipid metabolism	0.0182092864081707	-4.0058235728215	90	23	0.013561320754717	1696	10287	1455,2581,3074,64781,2629,427,285362,25870,23344,153642,4758,23683,221,29095,253782,5476,51228,5660,55627,171546,3073,2760,57488	CSNK1G2,GALC,HEXB,CERK,GBA,ASAH1,SUMF1,SUMF2,ESYT1,ARSK,NEU1,PRKD3,ALDH3B1,ORMDL2,CERS6,CTSA,GLTP,PSAP,SMPD4,SPTSSA,HEXA,GM2A,ESYT2
R-HSA-379716	Cytosolic tRNA aminoacylation	0.0190857991075516	-3.95881072268684	26	9	0.00530660377358491	1696	10287	2193,3735,2058,51520,3376,3035,5859,5464,6897	FARSA,KARS,EPRS,LARS,IARS,HARS,QARS,PPA1,TARS
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	0.0190857991075516	-3.95881072268684	26	9	0.00530660377358491	1696	10287	4122,9334,2530,2683,8703,8128,8702,4249,8704	MAN2A2,B4GALT5,FUT8,B4GALT1,B4GALT3,ST8SIA2,B4GALT4,MGAT5,B4GALT2
R-HSA-1912420	Pre-NOTCH Processing in Golgi	0.0194109889347018	-3.94191593334632	18	7	0.00412735849056604	1696	10287	2683,5870,4853,488,10959,6400,4242	B4GALT1,RAB6A,NOTCH2,ATP2A2,TMED2,SEL1L,MFNG
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.019590926581846	-3.93268874942826	22	8	0.00471698113207547	1696	10287	163,1174,55690,375,162,1175,3105,8907	AP2B1,AP1S1,PACS1,ARF1,AP1B1,AP2S1,HLA-A,AP1M1
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.019590926581846	-3.93268874942826	22	8	0.00471698113207547	1696	10287	6233,11253,6400,84447,55741,11236,6048,7844	RPS27A,MAN1B1,SEL1L,SYVN1,EDEM2,RNF139,RNF5,RNF103
R-HSA-198753	ERK/MAPK targets	0.019590926581846	-3.93268874942826	22	8	0.00471698113207547	1696	10287	5515,4205,2002,1845,5594,1432,6195,5595	PPP2CA,MEF2A,ELK1,DUSP3,MAPK1,MAPK14,RPS6KA1,MAPK3
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.019840276750969	-3.92004122808112	156	36	0.0212264150943396	1696	10287	9371,5879,11311,3831,9493,29127,3661,11004,139818,5566,3833,1020,3799,998,23303,829,22920,3835,81928,55604,5575,56992,23186,830,3832,9927,8165,3796,5889,81930,146909,7975,3020,1017,91768,3066	KIF3B,RAC1,VPS45,KLC1,KIF23,RACGAP1,IRF3,KIF2C,DOCK11,PRKACA,KIFC1,CDK5,KIF5B,CDC42,KIF13B,CAPZA1,KIFAP3,KIF22,CABLES2,CARMIL1,PRKAR1B,KIF15,RCOR1,CAPZA2,KIF11,MFN2,AKAP1,KIF2A,RAD51C,KIF18A,KIF18B,MAFK,H3F3A,CDK2,CABLES1,HDAC2
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	0.0201859738664325	-3.90276727880455	62	17	0.0100235849056604	1696	10287	11336,9371,51552,5564,208,5879,8766,805,4218,8773,5867,60412,7534,22920,7533,9847,4644	EXOC3,KIF3B,RAB14,PRKAB1,AKT2,RAC1,RAB11A,CALM2,RAB8A,SNAP23,RAB4A,EXOC4,YWHAZ,KIFAP3,YWHAH,C2CD5,MYO5A
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	0.0210619543292732	-3.86028697842067	67	18	0.0106132075471698	1696	10287	7323,5708,5707,5687,143471,9978,6233,5714,7428,5709,5695,5682,5698,5715,5700,5691,5704,54583	UBE2D3,PSMD2,PSMD1,PSMA6,PSMA8,RBX1,RPS27A,PSMD8,VHL,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4,EGLN1
R-HSA-5578749	Transcriptional regulation by small RNAs	0.0211465640896707	-3.85627784107609	106	26	0.0153301886792453	1696	10287	55706,5438,3015,23511,5436,5441,5440,8480,27161,53371,5433,9631,94239,23165,5430,23225,5439,57122,3014,23636,9972,3020,79902,9818,8086,81929	NDC1,POLR2I,H2AFZ,NUP188,POLR2G,POLR2L,POLR2K,RAE1,AGO2,NUP54,POLR2D,NUP155,H2AFV,NUP205,POLR2A,NUP210,POLR2J,NUP107,H2AFX,NUP62,NUP153,H3F3A,NUP85,NUP58,AAAS,SEH1L
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.0217798404409315	-3.82677048744853	72	19	0.0112028301886792	1696	10287	5347,11116,22919,8655,10540,54930,5566,55142,93323,5108,9738,55835,4957,8636,80254,54820,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,DYNLL1,DCTN2,HAUS4,PRKACA,HAUS2,HAUS8,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,TUBB,CSNK1D,DCTN1
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	0.0217798404409315	-3.82677048744853	72	19	0.0112028301886792	1696	10287	5347,11116,22919,8655,10540,54930,5566,55142,93323,5108,9738,55835,4957,8636,80254,54820,203068,1453,1639	PLK1,FGFR1OP,MAPRE1,DYNLL1,DCTN2,HAUS4,PRKACA,HAUS2,HAUS8,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,TUBB,CSNK1D,DCTN1
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	0.0224972418026077	-3.79436256383688	58	16	0.00943396226415094	1696	10287	143471,5695,5682,84447,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,6400,5700	PSMA8,PSMB7,PSMA1,SYVN1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.0229943900934805	-3.77250500178273	31	10	0.00589622641509434	1696	10287	5515,1845,6195,4205,2002,1385,1432,5594,1386,5595	PPP2CA,DUSP3,RPS6KA1,MEF2A,ELK1,CREB1,MAPK14,MAPK1,ATF2,MAPK3
R-HSA-114452	Activation of BH3-only proteins	0.0229943900934805	-3.77250500178273	31	10	0.00589622641509434	1696	10287	208,8655,7027,1869,5534,7534,596,7159,7029,7533	AKT2,DYNLL1,TFDP1,E2F1,PPP3R1,YWHAZ,BCL2,TP53BP2,TFDP2,YWHAH
R-HSA-180786	Extension of Telomeres	0.0229943900934805	-3.77250500178273	31	10	0.00589622641509434	1696	10287	23649,6118,5111,5983,5426,5558,10856,5982,5557,6117	POLA2,RPA2,PCNA,RFC3,POLE,PRIM2,RUVBL2,RFC2,PRIM1,RPA1
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	0.0231045307555557	-3.76772654408252	132	31	0.0182783018867925	1696	10287	2067,5983,63967,51426,10635,6613,29086,116028,7156,672,641,7329,5982,80010,6117,6118,5889,5111,890,9577,79728,5426,6233,7516,3014,8914,7517,1017,348654,23514,5892	ERCC1,RFC3,CLSPN,POLK,RAD51AP1,SUMO2,BABAM1,RMI2,TOP3A,BRCA1,BLM,UBE2I,RFC2,RMI1,RPA1,RPA2,RAD51C,PCNA,CCNA2,BABAM2,PALB2,POLE,RPS27A,XRCC2,H2AFX,TIMELESS,XRCC3,CDK2,GEN1,SPIDR,RAD51D
R-HSA-1059683	Interleukin-6 signaling	0.023382746881582	-3.75575684132012	11	5	0.00294811320754717	1696	10287	3716,6774,3572,6772,5781	JAK1,STAT3,IL6ST,STAT1,PTPN11
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.023382746881582	-3.75575684132012	11	5	0.00294811320754717	1696	10287	7884,6637,25888,6634,6628	SLBP,SNRPG,ZNF473,SNRPD3,SNRPB
R-HSA-1226099	Signaling by FGFR in disease	0.0235281753036259	-3.74955662690705	63	17	0.0100235849056604	1696	10287	11116,5438,4893,5436,5441,5440,5433,3845,5430,2962,2261,5439,399687,6772,6774,3265,26127	FGFR1OP,POLR2I,NRAS,POLR2G,POLR2L,POLR2K,POLR2D,KRAS,POLR2A,GTF2F1,FGFR3,POLR2J,MYO18A,STAT1,STAT3,HRAS,FGFR1OP2
R-HSA-5675221	Negative regulation of MAPK pathway	0.0239531716019984	-3.73165453792205	40	12	0.00707547169811321	1696	10287	5515,4893,5525,6233,5894,8315,3845,5536,5594,3265,5605,5595	PPP2CA,NRAS,PPP2R5A,RPS27A,RAF1,BRAP,KRAS,PPP5C,MAPK1,HRAS,MAP2K2,MAPK3
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.0239531716019984	-3.73165453792205	40	12	0.00707547169811321	1696	10287	6118,5889,5983,7516,116028,7156,672,641,5982,80010,5892,6117	RPA2,RAD51C,RFC3,XRCC2,RMI2,TOP3A,BRCA1,BLM,RFC2,RMI1,RAD51D,RPA1
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.0245488917102649	-3.70708856994536	27	9	0.00530660377358491	1696	10287	5438,5436,5441,5439,5440,5433,2966,5430,2962	POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,GTF2H2,POLR2A,GTF2F1
R-HSA-901042	Calnexin/calreticulin cycle	0.0245488917102649	-3.70708856994536	27	9	0.00530660377358491	1696	10287	5589,6233,11253,6400,84447,55741,11236,6048,7844	PRKCSH,RPS27A,MAN1B1,SEL1L,SYVN1,EDEM2,RNF139,RNF5,RNF103
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.0245488917102649	-3.70708856994536	27	9	0.00530660377358491	1696	10287	5438,5439,5436,5441,5440,5433,2966,5430,2962	POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,GTF2H2,POLR2A,GTF2F1
R-HSA-421837	Clathrin derived vesicle budding	0.0250343215444655	-3.68750753384844	73	19	0.0112028301886792	1696	10287	27243,2512,6643,10618,375,162,23431,1176,8301,351,7037,2799,9146,8773,1785,8907,1174,1212,23557	CHMP2A,FTL,SNX2,TGOLN2,ARF1,AP1B1,AP4E1,AP3S1,PICALM,APP,TFRC,GNS,HGS,SNAP23,DNM2,AP1M1,AP1S1,CLTB,SNAPIN
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.0250343215444655	-3.68750753384844	73	19	0.0112028301886792	1696	10287	27243,2512,6643,10618,375,162,23431,1176,8301,351,7037,2799,9146,8773,1785,8907,1174,1212,23557	CHMP2A,FTL,SNX2,TGOLN2,ARF1,AP1B1,AP4E1,AP3S1,PICALM,APP,TFRC,GNS,HGS,SNAP23,DNM2,AP1M1,AP1S1,CLTB,SNAPIN
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	0.0250708989780522	-3.68604750873717	54	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,11200,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CHEK2,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	0.0250708989780522	-3.68604750873717	54	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,11200,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CHEK2,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-1592230	Mitochondrial biogenesis	0.0250708989780522	-3.68604750873717	54	15	0.00884433962264151	1696	10287	5564,4899,7978,2551,56652,54205,8648,4209,506,1385,1432,11232,1386,10499,10498	PRKAB1,NRF1,MTERF1,GABPA,TWNK,CYCS,NCOA1,MEF2D,ATP5F1B,CREB1,MAPK14,POLG2,ATF2,NCOA2,CARM1
R-HSA-69610	p53-Independent DNA Damage Response	0.0250708989780522	-3.68604750873717	54	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,11200,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CHEK2,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-5693538	Homology Directed Repair	0.0252314456844963	-3.67966421775292	138	32	0.0188679245283019	1696	10287	63967,6613,29086,116028,641,7329,80010,6118,5111,890,9577,7516,8914,23514,2067,5983,51426,10635,7156,672,5982,6117,5889,5426,79728,6233,3014,7517,348654,1017,5892,10721	CLSPN,SUMO2,BABAM1,RMI2,BLM,UBE2I,RMI1,RPA2,PCNA,CCNA2,BABAM2,XRCC2,TIMELESS,SPIDR,ERCC1,RFC3,POLK,RAD51AP1,TOP3A,BRCA1,RFC2,RPA1,RAD51C,POLE,PALB2,RPS27A,H2AFX,XRCC3,GEN1,CDK2,RAD51D,POLQ
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.0259446780256395	-3.65178877612036	83	21	0.0123820754716981	1696	10287	143471,9978,5695,5682,8454,23401,1452,5698,5715,5691,5704,5515,5708,5687,5707,5525,6233,5714,8312,5709,5700	PSMA8,RBX1,PSMB7,PSMA1,CUL1,FRAT2,CSNK1A1,PSMB9,PSMD9,PSMB3,PSMC4,PPP2CA,PSMD2,PSMA6,PSMD1,PPP2R5A,RPS27A,PSMD8,AXIN1,PSMD3,PSMC1
R-HSA-5358508	Mismatch Repair	0.0259766244030814	-3.65055820677872	15	6	0.0035377358490566	1696	10287	6118,5111,2956,6117,5395,4436	RPA2,PCNA,MSH6,RPA1,PMS2,MSH2
R-HSA-69183	Processive synthesis on the lagging strand	0.0259766244030814	-3.65055820677872	15	6	0.0035377358490566	1696	10287	23649,6118,5111,5558,6117,5557	POLA2,RPA2,PCNA,PRIM2,RPA1,PRIM1
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.026140155418331	-3.64428262519046	45	13	0.00766509433962264	1696	10287	4899,7978,2551,56652,54205,8648,4209,506,1385,11232,1386,10499,10498	NRF1,MTERF1,GABPA,TWNK,CYCS,NCOA1,MEF2D,ATP5F1B,CREB1,POLG2,ATF2,NCOA2,CARM1
R-HSA-432720	Lysosome Vesicle Biogenesis	0.0262575126604397	-3.63980313430275	36	11	0.00648584905660377	1696	10287	2799,27243,9146,8907,1785,1174,375,162,1212,23431,351	GNS,CHMP2A,HGS,AP1M1,DNM2,AP1S1,ARF1,AP1B1,CLTB,AP4E1,APP
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.0264610414602025	-3.63208176127389	19	7	0.00412735849056604	1696	10287	29882,51434,8881,8697,996,11065,29945	ANAPC2,ANAPC7,CDC16,CDC23,CDC27,UBE2C,ANAPC4
R-HSA-110320	Translesion Synthesis by POLH	0.0264610414602025	-3.63208176127389	19	7	0.00412735849056604	1696	10287	6118,5111,5983,5982,6233,55666,6117	RPA2,PCNA,RFC3,RFC2,RPS27A,NPLOC4,RPA1
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.0264610414602025	-3.63208176127389	19	7	0.00412735849056604	1696	10287	5111,7029,891,5933,1874,7027,10498	PCNA,TFDP2,CCNB1,RBL1,E2F4,TFDP1,CARM1
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.0271681640285907	-3.60570943130551	2	2	0.00117924528301887	1696	10287	5347,26271	PLK1,FBXO5
R-HSA-71737	Pyrophosphate hydrolysis	0.0271681640285907	-3.60570943130551	2	2	0.00117924528301887	1696	10287	5464,27068	PPA1,PPA2
R-HSA-165160	PDE3B signalling	0.0271681640285907	-3.60570943130551	2	2	0.00117924528301887	1696	10287	5140,208	PDE3B,AKT2
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.0271681640285907	-3.60570943130551	2	2	0.00117924528301887	1696	10287	6888,7086	TALDO1,TKT
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.0279334507908017	-3.57793035524975	50	14	0.00825471698113208	1696	10287	9150,5438,5439,5436,5441,5440,6924,5433,6917,2966,5430,2962,6749,11198	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,GTF2H2,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.0279334507908017	-3.57793035524975	50	14	0.00825471698113208	1696	10287	9150,5438,5439,5436,5441,5440,6924,5433,6917,2966,5430,2962,6749,11198	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,GTF2H2,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-73887	Death Receptor Signalling	0.0279334507908017	-3.57793035524975	50	14	0.00825471698113208	1696	10287	6868,1540,7128,330,23118,6233,331,56928,27005,329,8772,8837,84888,355	ADAM17,CYLD,TNFAIP3,BIRC3,TAB2,RPS27A,XIAP,SPPL2B,USP21,BIRC2,FADD,CFLAR,SPPL2A,FAS
R-HSA-167169	HIV Transcription Elongation	0.0279334507908017	-3.57793035524975	50	14	0.00825471698113208	1696	10287	9150,5438,5439,5436,5441,5440,6924,5433,6917,2966,5430,2962,6749,11198	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,TCEA1,GTF2H2,POLR2A,GTF2F1,SSRP1,SUPT16H
R-HSA-5619084	ABC transporter disorders	0.0280480065184348	-3.57383771840045	69	18	0.0106132075471698	1696	10287	143471,10613,5695,5682,5698,5715,5691,5704,79139,5708,5687,5707,6233,5709,5714,6400,5700,6048	PSMA8,ERLIN1,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,DERL1,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1,RNF5
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	0.0289382093008021	-3.54259243596128	41	12	0.00707547169811321	1696	10287	6118,5111,5983,5426,51426,6233,9100,5982,10459,55666,9636,6117	RPA2,PCNA,RFC3,POLE,POLK,RPS27A,USP10,RFC2,MAD2L2,NPLOC4,ISG15,RPA1
R-HSA-180585	Vif-mediated degradation of APOBEC3G	0.0293847903528044	-3.52727807344002	55	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,9978,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RBX1,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-68952	DNA replication initiation	0.0294907013393078	-3.52368027416213	8	4	0.00235849056603774	1696	10287	23649,5426,5558,5557	POLA2,POLE,PRIM2,PRIM1
R-HSA-174430	Telomere C-strand synthesis initiation	0.0294907013393078	-3.52368027416213	8	4	0.00235849056603774	1696	10287	23649,5426,5558,5557	POLA2,POLE,PRIM2,PRIM1
R-HSA-190236	Signaling by FGFR	0.0295866832257905	-3.52043090990404	89	22	0.0129716981132075	1696	10287	5438,4893,5436,5441,5440,5433,3185,7072,3845,5430,5595,2962,5515,2261,8569,6464,5439,6233,5781,5594,3265,4670	POLR2I,NRAS,POLR2G,POLR2L,POLR2K,POLR2D,HNRNPF,TIA1,KRAS,POLR2A,MAPK3,GTF2F1,PPP2CA,FGFR3,MKNK1,SHC1,POLR2J,RPS27A,PTPN11,MAPK1,HRAS,HNRNPM
R-HSA-5387390	Hh mutants abrogate ligand secretion	0.0305413737425601	-3.48867299845608	60	16	0.00943396226415094	1696	10287	143471,5695,5682,84447,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,6400,5700	PSMA8,PSMB7,PSMA1,SYVN1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.0310357466798819	-3.47261562012185	28	9	0.00530660377358491	1696	10287	22931,2590,8655,10540,56894,23299,5870,1783,1639	RAB18,GALNT2,DYNLL1,DCTN2,AGPAT3,BICD2,RAB6A,DYNC1LI2,DCTN1
R-HSA-74752	Signaling by Insulin receptor	0.0316351600054553	-3.45348611853437	322	66	0.0389150943396226	1696	10287	5564,7249,4763,5894,64121,526,29904,805,533,5906,5707,5687,6464,5296,64223,9550,4893,143471,9978,208,8452,5695,535,5698,6009,5515,5525,3716,6233,5714,5709,51719,527,6794,5536,409,5594,5700,8992,5562,8649,8315,84335,5715,5708,2261,5781,23545,9114,818,6709,5170,5682,3845,5140,5605,5691,5595,5704,7248,51382,1445,389541,84078,528,3265	PRKAB1,TSC2,NF1,RAF1,RRAGC,ATP6V1B2,EEF2K,CALM2,ATP6V0B,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,MLST8,ATP6V1G1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,ATP6V0A1,PSMB9,RHEB,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,CAB39,ATP6V0C,STK11,PPP5C,ARRB2,MAPK1,PSMC1,ATP6V0E1,PRKAA1,LAMTOR3,BRAP,AKT1S1,PSMD9,PSMD2,FGFR3,PTPN11,ATP6V0A2,ATP6V0D1,CAMK2G,SPTAN1,PDPK1,PSMA1,KRAS,PDE3B,MAP2K2,PSMB3,MAPK3,PSMC4,TSC1,ATP6V1D,CSK,LAMTOR4,KBTBD7,ATP6V1C1,HRAS
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.0319707510118632	-3.44293382504263	37	11	0.00648584905660377	1696	10287	6118,5111,5983,5426,8505,4350,5982,4968,252969,8930,6117	RPA2,PCNA,RFC3,POLE,PARG,MPG,RFC2,OGG1,NEIL2,MBD4,RPA1
R-HSA-73884	Base Excision Repair	0.0319707510118632	-3.44293382504263	37	11	0.00648584905660377	1696	10287	6118,5111,5983,5426,8505,4350,5982,4968,252969,8930,6117	RPA2,PCNA,RFC3,POLE,PARG,MPG,RFC2,OGG1,NEIL2,MBD4,RPA1
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	0.0328509850712871	-3.41577354755174	51	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.033159242255316	-3.40643380014272	100	24	0.0141509433962264	1696	10287	5347,11116,261734,22919,8655,10540,51259,54930,117177,5566,8766,55142,93323,4218,5108,9738,55835,4957,8636,80254,54820,1453,203068,1639	PLK1,FGFR1OP,NPHP4,MAPRE1,DYNLL1,DCTN2,TMEM216,HAUS4,RAB3IP,PRKACA,RAB11A,HAUS2,HAUS8,RAB8A,PCM1,CCP110,CENPJ,ODF2,SSNA1,CEP63,NDE1,CSNK1D,TUBB,DCTN1
R-HSA-5687128	MAPK6/MAPK4 signaling	0.0332676057256997	-3.40317115650379	90	22	0.0129716981132075	1696	10287	143471,27161,5879,5695,5682,3337,989,5566,5698,5715,2309,5691,5704,5708,5687,5707,998,6233,5714,5709,5597,5700	PSMA8,AGO2,RAC1,PSMB7,PSMA1,DNAJB1,SEPT7,PRKACA,PSMB9,PSMD9,FOXO3,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,CDC42,RPS27A,PSMD8,PSMD3,MAPK6,PSMC1
R-HSA-111448	Activation of NOXA and translocation to mitochondria	0.0344250061264332	-3.36897205640278	5	3	0.0017688679245283	1696	10287	7029,7027,1869	TFDP2,TFDP1,E2F1
R-HSA-69478	G2/M DNA replication checkpoint	0.0344250061264332	-3.36897205640278	5	3	0.0017688679245283	1696	10287	9088,891,9133	PKMYT1,CCNB1,CCNB2
R-HSA-1169092	Activation of RAS in B cells	0.0344250061264332	-3.36897205640278	5	3	0.0017688679245283	1696	10287	3845,4893,3265	KRAS,NRAS,HRAS
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.034631350051871	-3.36299593628956	42	12	0.00707547169811321	1696	10287	4234,348180,2058,112858,51605,55253,10785,54888,129450,24140,8270,54920	METTL1,CTU2,EPRS,TP53RK,TRMT6,TYW1,WDR4,NSUN2,TYW5,FTSJ1,LAGE3,DUS2
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.0347497745359675	-3.35958219516598	12	5	0.00294811320754717	1696	10287	159,158,3614,2618,471	ADSS,ADSL,IMPDH1,GART,ATIC
R-HSA-1236977	Endosomal/Vacuolar pathway	0.0347497745359675	-3.35958219516598	12	5	0.00294811320754717	1696	10287	1514,3106,1520,3133,3105	CTSL,HLA-B,CTSS,HLA-E,HLA-A
R-HSA-5689877	Josephin domain DUBs	0.0347497745359675	-3.35958219516598	12	5	0.00294811320754717	1696	10287	9929,4287,6233,5887,5886	JOSD1,ATXN3,RPS27A,RAD23B,RAD23A
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.0350700553637681	-3.35040763616668	20	7	0.00412735849056604	1696	10287	29882,51434,8881,8697,996,11065,29945	ANAPC2,ANAPC7,CDC16,CDC23,CDC27,UBE2C,ANAPC4
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.0350700553637681	-3.35040763616668	20	7	0.00412735849056604	1696	10287	29882,51434,8881,8697,996,11065,29945	ANAPC2,ANAPC7,CDC16,CDC23,CDC27,UBE2C,ANAPC4
R-HSA-1222556	ROS, RNS production in phagocytes	0.03521719809535	-3.34622073344127	33	10	0.00589622641509434	1696	10287	533,51382,23545,535,527,528,526,8992,9114,9550	ATP6V0B,ATP6V1D,ATP6V0A2,ATP6V0A1,ATP6V0C,ATP6V1C1,ATP6V1B2,ATP6V0E1,ATP6V0D1,ATP6V1G1
R-HSA-4085001	Sialic acid metabolism	0.03521719809535	-3.34622073344127	33	10	0.00589622641509434	1696	10287	55907,10020,5476,6483,26503,54187,140838,8128,10559,4758	CMAS,GNE,CTSA,ST3GAL2,SLC17A5,NANS,NANP,ST8SIA2,SLC35A1,NEU1
R-HSA-1295596	Spry regulation of FGF signaling	0.0359049396228274	-3.32688039900246	16	6	0.0035377358490566	1696	10287	5515,8569,5594,6233,5595,5781	PPP2CA,MKNK1,MAPK1,RPS27A,MAPK3,PTPN11
R-HSA-5218859	Regulated Necrosis	0.0359049396228274	-3.32688039900246	16	6	0.0035377358490566	1696	10287	330,329,8772,8837,331,355	BIRC3,BIRC2,FADD,CFLAR,XIAP,FAS
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.0359049396228274	-3.32688039900246	16	6	0.0035377358490566	1696	10287	330,329,8772,8837,331,355	BIRC3,BIRC2,FADD,CFLAR,XIAP,FAS
R-HSA-5610787	Hedgehog 'off' state	0.0369310872655824	-3.2987016092951	101	24	0.0141509433962264	1696	10287	143471,9978,5575,5695,5682,8454,1452,5566,5715,5698,5691,5704,2778,5708,5687,5707,6233,5714,5709,7289,115,5700,8650,113	PSMA8,RBX1,PRKAR1B,PSMB7,PSMA1,CUL1,CSNK1A1,PRKACA,PSMD9,PSMB9,PSMB3,PSMC4,GNAS,PSMD2,PSMA6,PSMD1,RPS27A,PSMD8,PSMD3,TULP3,ADCY9,PSMC1,NUMB,ADCY7
R-HSA-8856828	Clathrin-mediated endocytosis	0.0371993127918776	-3.29146499121029	137	31	0.0182783018867925	1696	10287	10920,9185,9322,10096,29924,10618,3267,154,29978,10552,5869,8027,85021,8301,7037,23396,55707,950,9146,156,6233,112574,10092,1785,163,64708,10980,1212,409,1175,1856	COPS8,REPS2,TRIP10,ACTR3,EPN1,TGOLN2,AGFG1,ADRB2,UBQLN2,ARPC1A,RAB5B,STAM,REPS1,PICALM,TFRC,PIP5K1C,NECAP2,SCARB2,HGS,GRK2,RPS27A,SNX18,ARPC5,DNM2,AP2B1,COPS7B,COPS6,CLTB,ARRB2,AP2S1,DVL2
R-HSA-70326	Glucose metabolism	0.0372346176717836	-3.29051636785174	81	20	0.0117924528301887	1696	10287	7360,10007,4191,5209,8604,83440,2992,5315,5566,7957,5515,805,6233,2806,4190,2821,5223,5261,5214,6576	UGP2,GNPDA1,MDH2,PFKFB3,SLC25A12,ADPGK,GYG1,PKM,PRKACA,EPM2A,PPP2CA,CALM2,RPS27A,GOT2,MDH1,GPI,PGAM1,PHKG2,PFKP,SLC25A1
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	0.0383663333770268	-3.26057493891861	52	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	0.0383663333770268	-3.26057493891861	52	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-72086	mRNA Capping	0.0386239569457752	-3.25388254876898	29	9	0.00530660377358491	1696	10287	5438,5436,5441,5439,5440,5433,2966,5430,2962	POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,GTF2H2,POLR2A,GTF2F1
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	0.0396097811453141	-3.2286791926018	57	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,26986,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PABPC1,PSMB3,PSMC4
R-HSA-187037	NGF signalling via TRKA from the plasma membrane	0.0404860008736283	-3.20679902206422	387	77	0.0454009433962264	1696	10287	7249,4763,6195,5894,5566,1432,1399,805,7409,5906,4193,5707,5687,6464,5899,5296,115,1785,163,1027,10768,10126,64223,113,4893,143471,9978,208,8452,5695,5698,5515,5525,3716,6233,5714,5709,5536,409,5594,5700,1175,27161,8649,8315,4205,84335,5715,2309,5305,23396,5708,2261,156,5728,5781,1385,6774,818,6709,5170,387,7867,5575,79837,5682,3845,6016,2002,5605,5691,5595,5704,1845,1445,84078,3265	TSC2,NF1,RPS6KA1,RAF1,PRKACA,MAPK14,CRKL,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,RALB,PIK3R2,ADCY9,DNM2,AP2B1,CDKN1B,AHCYL1,DNAL4,MLST8,ADCY7,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,AP2S1,AGO2,LAMTOR3,BRAP,MEF2A,AKT1S1,PSMD9,FOXO3,PIP4K2A,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,STAT3,CAMK2G,SPTAN1,PDPK1,RHOA,MAPKAPK3,PRKAR1B,PIP4K2C,PSMA1,KRAS,RIT1,ELK1,MAP2K2,PSMB3,MAPK3,PSMC4,DUSP3,CSK,KBTBD7,HRAS
R-HSA-75893	TNF signaling	0.0410767823623973	-3.19231222312387	43	12	0.00707547169811321	1696	10287	6868,1540,7128,330,23118,6233,331,27005,329,56928,8772,84888	ADAM17,CYLD,TNFAIP3,BIRC3,TAB2,RPS27A,XIAP,USP21,BIRC2,SPPL2B,FADD,SPPL2A
R-HSA-5358346	Hedgehog ligand biogenesis	0.0411735232955317	-3.18995986766523	67	17	0.0100235849056604	1696	10287	6868,143471,5695,5682,84447,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,6400,5700	ADAM17,PSMA8,PSMB7,PSMA1,SYVN1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1
R-HSA-2262749	Cellular response to hypoxia	0.0418194584829136	-3.17439353382413	77	19	0.0112028301886792	1696	10287	7323,143471,9978,7428,5695,5682,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,10370,5700,54583	UBE2D3,PSMA8,RBX1,VHL,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,CITED2,PSMC1,EGLN1
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	0.0418194584829136	-3.17439353382413	77	19	0.0112028301886792	1696	10287	7323,143471,9978,7428,5695,5682,5698,5715,5691,5704,5708,5687,5707,6233,5709,5714,10370,5700,54583	UBE2D3,PSMA8,RBX1,VHL,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,CITED2,PSMC1,EGLN1
R-HSA-5673000	RAF activation	0.0420766457514691	-3.16826242495914	25	8	0.00471698113207547	1696	10287	5515,4893,5525,5894,8315,3845,3265,5605	PPP2CA,NRAS,PPP2R5A,RAF1,BRAP,KRAS,HRAS,MAP2K2
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.0420766457514691	-3.16826242495914	25	8	0.00471698113207547	1696	10287	6118,5111,5983,5426,51426,6233,5982,6117	RPA2,PCNA,RFC3,POLE,POLK,RPS27A,RFC2,RPA1
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.0420766457514691	-3.16826242495914	25	8	0.00471698113207547	1696	10287	8881,996,6233,51434,29882,8697,11065,29945	CDC16,CDC27,RPS27A,ANAPC7,ANAPC2,CDC23,UBE2C,ANAPC4
R-HSA-162588	Budding and maturation of HIV virion	0.0420766457514691	-3.16826242495914	25	8	0.00471698113207547	1696	10287	27243,29082,10015,6233,128866,27183,25978,91782	CHMP2A,CHMP4A,PDCD6IP,RPS27A,CHMP4B,VPS4A,CHMP2B,CHMP7
R-HSA-5656169	Termination of translesion DNA synthesis	0.0427665143377064	-3.15199985789689	34	10	0.00589622641509434	1696	10287	6118,5111,5983,5426,51426,6233,9100,5982,9636,6117	RPA2,PCNA,RFC3,POLE,POLK,RPS27A,USP10,RFC2,ISG15,RPA1
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.0427665143377064	-3.15199985789689	34	10	0.00589622641509434	1696	10287	892,8812,4087,5933,6233,1874,7027,7029,4221,4089	CCNC,CCNK,SMAD2,RBL1,RPS27A,E2F4,TFDP1,TFDP2,MEN1,SMAD4
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.0427665143377064	-3.15199985789689	34	10	0.00589622641509434	1696	10287	7040,2280,4087,9110,6233,51377,57154,9040,11171,4089	TGFB1,FKBP1A,SMAD2,MTMR4,RPS27A,UCHL5,SMURF1,UBE2M,STRAP,SMAD4
R-HSA-180534	Vpu mediated degradation of CD4	0.0445116222958101	-3.1120049487235	53	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	0.0445116222958101	-3.1120049487235	53	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-69618	Mitotic Spindle Checkpoint	0.0453454343532483	-3.09344578327198	21	7	0.00412735849056604	1696	10287	29882,51434,8881,8697,996,11065,29945	ANAPC2,ANAPC7,CDC16,CDC23,CDC27,UBE2C,ANAPC4
R-HSA-445144	Signal transduction by L1	0.0453454343532483	-3.09344578327198	21	7	0.00412735849056604	1696	10287	1457,5594,5605,7410,5879,5595,3688	CSNK2A1,MAPK1,MAP2K2,VAV2,RAC1,MAPK3,ITGB1
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.0455792716137203	-3.08830223568456	58	15	0.00884433962264151	1696	10287	142678,892,9612,6868,2648,102,9978,51107,6233,51564,8454,3516,9794,83464,3066	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,RPS27A,HDAC7,CUL1,RBPJ,MAML1,APH1B,HDAC2
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.0455792716137203	-3.08830223568456	58	15	0.00884433962264151	1696	10287	142678,892,9612,6868,2648,102,9978,51107,6233,51564,8454,3516,9794,83464,3066	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,RPS27A,HDAC7,CUL1,RBPJ,MAML1,APH1B,HDAC2
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.0455792716137203	-3.08830223568456	58	15	0.00884433962264151	1696	10287	142678,892,9612,6868,2648,102,9978,51107,6233,51564,8454,3516,9794,83464,3066	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,RPS27A,HDAC7,CUL1,RBPJ,MAML1,APH1B,HDAC2
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.0455792716137203	-3.08830223568456	58	15	0.00884433962264151	1696	10287	142678,892,9612,6868,2648,102,9978,51107,6233,51564,8454,3516,9794,83464,3066	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,RPS27A,HDAC7,CUL1,RBPJ,MAML1,APH1B,HDAC2
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.0455792716137203	-3.08830223568456	58	15	0.00884433962264151	1696	10287	142678,892,9612,6868,2648,102,9978,51107,6233,51564,8454,3516,9794,83464,3066	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,RPS27A,HDAC7,CUL1,RBPJ,MAML1,APH1B,HDAC2
R-HSA-5674135	MAP2K and MAPK activation	0.0459319365547713	-3.08059461835515	39	11	0.00648584905660377	1696	10287	5906,4893,1445,5894,8649,3845,5594,409,3265,5605,5595	RAP1A,NRAS,CSK,RAF1,LAMTOR3,KRAS,MAPK1,ARRB2,HRAS,MAP2K2,MAPK3
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.0459319365547713	-3.08059461835515	39	11	0.00648584905660377	1696	10287	10920,9978,6233,5887,60,64708,283899,10980,7528,1642,5886	COPS8,RBX1,RPS27A,RAD23B,ACTB,COPS7B,INO80E,COPS6,YY1,DDB1,RAD23A
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.0459319365547713	-3.08059461835515	39	11	0.00648584905660377	1696	10287	2339,118,63967,839,5339,6093,2620,10134,329,4000,6709	FNTA,ADD1,CLSPN,CASP6,PLEC,ROCK1,GAS2,BCAP31,BIRC2,LMNA,SPTAN1
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.0459319365547713	-3.08059461835515	39	11	0.00648584905660377	1696	10287	5906,4893,1445,5894,8315,3845,5594,409,3265,5605,5595	RAP1A,NRAS,CSK,RAF1,BRAP,KRAS,MAPK1,ARRB2,HRAS,MAP2K2,MAPK3
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.0459319365547713	-3.08059461835515	39	11	0.00648584905660377	1696	10287	5906,4893,1445,5894,8315,3845,5594,409,3265,5605,5595	RAP1A,NRAS,CSK,RAF1,BRAP,KRAS,MAPK1,ARRB2,HRAS,MAP2K2,MAPK3
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	0.0462782980218922	-3.07308215300507	9	4	0.00235849056603774	1696	10287	387,389,388,6242	RHOA,RHOC,RHOB,RTKN
R-HSA-162592	Integration of provirus	0.0462782980218922	-3.07308215300507	9	4	0.00235849056603774	1696	10287	3836,7518,8815,7520	KPNA1,XRCC4,BANF1,XRCC5
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.0462782980218922	-3.07308215300507	9	4	0.00235849056603774	1696	10287	2280,7040,4087,4089	FKBP1A,TGFB1,SMAD2,SMAD4
R-HSA-2428933	SHC-related events triggered by IGF1R	0.0462782980218922	-3.07308215300507	9	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	0.0463147002624228	-3.07229586801418	63	16	0.00943396226415094	1696	10287	55907,64841,7264,8813,10020,26503,51005,54187,4758,116150,6675,6483,5476,8128,140838,10559	CMAS,GNPNAT1,TSTA3,DPM1,GNE,SLC17A5,AMDHD2,NANS,NEU1,NUS1,UAP1,ST3GAL2,CTSA,ST8SIA2,NANP,SLC35A1
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.0467760317946213	-3.06238434838817	68	17	0.0100235849056604	1696	10287	5441,115004,5440,5591,1660,84265,3661,351,51728,7520,6233,6778,23220,27297,148022,22954,3428	POLR2L,CGAS,POLR2K,PRKDC,DHX9,POLR3GL,IRF3,APP,POLR3K,XRCC5,RPS27A,STAT6,DTX4,CRCP,TICAM1,TRIM32,IFI16
R-HSA-1980143	Signaling by NOTCH1	0.0470106556893326	-3.05738098617414	73	18	0.0106132075471698	1696	10287	142678,892,9612,6868,2648,102,9978,51107,8454,83464,6233,51564,23220,3516,9794,409,3066,8650	MIB2,CCNC,NCOR2,ADAM17,KAT2A,ADAM10,RBX1,APH1A,CUL1,APH1B,RPS27A,HDAC7,DTX4,RBPJ,MAML1,ARRB2,HDAC2,NUMB
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.0473795760466945	-3.0495640282296	30	9	0.00530660377358491	1696	10287	142678,6868,102,51107,6233,23220,83464,409,8650	MIB2,ADAM17,ADAM10,APH1A,RPS27A,DTX4,APH1B,ARRB2,NUMB
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.0473795760466945	-3.0495640282296	30	9	0.00530660377358491	1696	10287	2648,27161,7027,1869,1871,4853,3516,7029,9794	KAT2A,AGO2,TFDP1,E2F1,E2F3,NOTCH2,RBPJ,TFDP2,MAML1
R-HSA-3232118	SUMOylation of transcription factors	0.0479699591096645	-3.03718031588328	17	6	0.0035377358490566	1696	10287	6670,4193,7329,9112,6613,1029	SP3,MDM2,UBE2I,MTA1,SUMO2,CDKN2A
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.0479699591096645	-3.03718031588328	17	6	0.0035377358490566	1696	10287	7040,2280,387,57154,6233,56288	TGFB1,FKBP1A,RHOA,SMURF1,RPS27A,PARD3
R-HSA-917937	Iron uptake and transport	0.0483140515108533	-3.03003283908332	44	12	0.00707547169811321	1696	10287	2512,533,51382,535,23545,527,526,528,9114,8992,7037,9550	FTL,ATP6V0B,ATP6V1D,ATP6V0A1,ATP6V0A2,ATP6V0C,ATP6V1B2,ATP6V1C1,ATP6V0D1,ATP6V0E1,TFRC,ATP6V1G1
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	2620,5339,118,839,6709	GAS2,PLEC,ADD1,CASP6,SPTAN1
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	3661,5591,3428,7520,23220	IRF3,PRKDC,IFI16,XRCC5,DTX4
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	1027,4193,84335,7249,208	CDKN1B,MDM2,AKT1S1,TSC2,AKT2
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	23141,5515,221496,8815,4000	ANKLE2,PPP2CA,LEMD2,BANF1,LMNA
R-HSA-2995410	Nuclear Envelope Reassembly	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	23141,5515,221496,8815,4000	ANKLE2,PPP2CA,LEMD2,BANF1,LMNA
R-HSA-2408517	SeMet incorporation into proteins	0.0489942366354293	-3.01605260747436	13	5	0.00294811320754717	1696	10287	3735,2058,51520,3376,5859	KARS,EPRS,LARS,IARS,QARS
R-HSA-212165	Epigenetic regulation of gene expression	0.0501838948919546	-2.99206112264321	151	33	0.0194575471698113	1696	10287	1788,3015,5440,23451,23512,7270,79595,200424,10849,9112,8932,84172,2966,30834,1786,79685,8819,2648,5441,11176,9219,53615,94239,221830,11335,7343,1107,3014,9031,60,5928,3020,3066	DNMT3A,H2AFZ,POLR2K,SF3B1,SUZ12,TTF1,SAP130,TET3,CD3EAP,MTA1,MBD2,POLR1B,GTF2H2,ZNRD1,DNMT1,SAP30L,SAP30,KAT2A,POLR2L,BAZ2A,MTA2,MBD3,H2AFV,TWISTNB,CBX3,UBTF,CHD3,H2AFX,BAZ1B,ACTB,RBBP4,H3F3A,HDAC2
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.0508438295477333	-2.97899651001121	99	23	0.013561320754717	1696	10287	10920,9185,29924,10618,3267,154,29978,8027,8301,85021,7037,55707,950,9146,156,6233,163,64708,10980,1212,409,1175,1856	COPS8,REPS2,EPN1,TGOLN2,AGFG1,ADRB2,UBQLN2,STAM,PICALM,REPS1,TFRC,NECAP2,SCARB2,HGS,GRK2,RPS27A,AP2B1,COPS7B,COPS6,CLTB,ARRB2,AP2S1,DVL2
R-HSA-114604	GPVI-mediated activation cascade	0.0513158754569059	-2.96975511158166	54	14	0.00825471698113208	1696	10287	5170,7409,391,387,6464,3716,998,208,5296,7410,5879,5781,4067,388	PDPK1,VAV1,RHOG,RHOA,SHC1,JAK1,CDC42,AKT2,PIK3R2,VAV2,RAC1,PTPN11,LYN,RHOB
R-HSA-169911	Regulation of Apoptosis	0.0513158754569059	-2.96975511158166	54	14	0.00825471698113208	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-113418	Formation of the Early Elongation Complex	0.0513452707478781	-2.9691824452349	35	10	0.00589622641509434	1696	10287	9150,5438,5436,5441,5439,5440,5433,2966,5430,2962	CTDP1,POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,GTF2H2,POLR2A,GTF2F1
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.0513452707478781	-2.9691824452349	35	10	0.00589622641509434	1696	10287	5906,4893,1445,5894,3845,5594,409,3265,5605,5595	RAP1A,NRAS,CSK,RAF1,KRAS,MAPK1,ARRB2,HRAS,MAP2K2,MAPK3
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.0513452707478781	-2.9691824452349	35	10	0.00589622641509434	1696	10287	9150,5438,5439,5436,5441,5440,5433,2966,5430,2962	CTDP1,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,GTF2H2,POLR2A,GTF2F1
R-HSA-8873719	RAB geranylgeranylation	0.0526621203603459	-2.94385886062117	64	16	0.00943396226415094	1696	10287	51552,9230,7879,51715,5870,5861,5869,8766,57403,84932,4218,22931,23011,53917,11021,5867	RAB14,RAB11B,RAB7A,RAB23,RAB6A,RAB1A,RAB5B,RAB11A,RAB22A,RAB2B,RAB8A,RAB18,RAB21,RAB24,RAB35,RAB4A
R-HSA-2871837	FCERI mediated NF-kB activation	0.0527481598384757	-2.9422263918131	79	19	0.0112028301886792	1696	10287	5170,143471,5695,5682,8454,7335,4067,5698,5715,5691,5704,5708,5687,5707,6233,23118,5709,5714,5700	PDPK1,PSMA8,PSMB7,PSMA1,CUL1,UBE2V1,LYN,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,TAB2,PSMD3,PSMD8,PSMC1
R-HSA-109704	PI3K Cascade	0.0527481598384757	-2.9422263918131	79	19	0.0112028301886792	1696	10287	5170,5564,7249,208,5562,8649,64121,84335,5140,6009,29904,7248,2261,389541,5296,5781,51719,6794,64223	PDPK1,PRKAB1,TSC2,AKT2,PRKAA1,LAMTOR3,RRAGC,AKT1S1,PDE3B,RHEB,EEF2K,TSC1,FGFR3,LAMTOR4,PIK3R2,PTPN11,CAB39,STK11,MLST8
R-HSA-5654741	Signaling by FGFR3	0.0542687094680145	-2.91380747103083	40	11	0.00648584905660377	1696	10287	5515,2261,8569,4893,6464,6233,5781,3845,5594,3265,5595	PPP2CA,FGFR3,MKNK1,NRAS,SHC1,RPS27A,PTPN11,KRAS,MAPK1,HRAS,MAPK3
R-HSA-5689603	UCH proteinases	0.0552476659298493	-2.89592918509023	105	24	0.0141509433962264	1696	10287	7040,221937,143471,5695,5682,283899,221656,5715,5698,55252,5691,5704,5708,5687,5707,6233,51377,5714,5709,8473,60,114785,7528,5700	TGFB1,FOXK1,PSMA8,PSMB7,PSMA1,INO80E,KDM1B,PSMD9,PSMB9,ASXL2,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,UCHL5,PSMD8,PSMD3,OGT,ACTB,MBD6,YY1,PSMC1
R-HSA-379724	tRNA Aminoacylation	0.0563772864525129	-2.87568892406577	45	12	0.00707547169811321	1696	10287	2193,3735,2058,51520,3376,3035,5859,27068,55699,5464,6897,79587	FARSA,KARS,EPRS,LARS,IARS,HARS,QARS,PPA2,IARS2,PPA1,TARS,CARS2
R-HSA-2682334	EPH-Ephrin signaling	0.0569478903301668	-2.86561863402151	95	22	0.0129716981132075	1696	10287	387,102,51107,10096,7410,5879,6383,4627,10552,83464,4067,998,10092,3984,163,60,6093,1212,1175,3265,103910,1072	RHOA,ADAM10,APH1A,ACTR3,VAV2,RAC1,SDC2,MYH9,ARPC1A,APH1B,LYN,CDC42,ARPC5,LIMK1,AP2B1,ACTB,ROCK1,CLTB,AP2S1,HRAS,MYL12B,CFL1
R-HSA-73772	RNA Polymerase I Promoter Escape	0.0573553339371971	-2.85848943298014	31	9	0.00530660377358491	1696	10287	7343,54700,5441,5440,10849,84172,30834,2966,221830	UBTF,RRN3,POLR2L,POLR2K,CD3EAP,POLR1B,ZNRD1,GTF2H2,TWISTNB
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.0573553339371971	-2.85848943298014	31	9	0.00530660377358491	1696	10287	25888,6628,7884,6637,10898,6634,8189,1477,10914	ZNF473,SNRPB,SLBP,SNRPG,CPSF4,SNRPD3,SYMPK,CSTF1,PAPOLA
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.0573642046459018	-2.85833478262447	22	7	0.00412735849056604	1696	10287	3845,4893,3384,5566,4067,3265,5894	KRAS,NRAS,ICAM2,PRKACA,LYN,HRAS,RAF1
R-HSA-166208	mTORC1-mediated signalling	0.0573642046459018	-2.85833478262447	22	7	0.00412735849056604	1696	10287	64121,84335,389541,6009,64223,8649,29904	RRAGC,AKT1S1,LAMTOR4,RHEB,MLST8,LAMTOR3,EEF2K
R-HSA-5620916	VxPx cargo-targeting to cilium	0.0573642046459018	-2.85833478262447	22	7	0.00412735849056604	1696	10287	11336,5311,4218,117177,8766,378,60412	EXOC3,PKD2,RAB8A,RAB3IP,RAB11A,ARF4,EXOC4
R-HSA-913531	Interferon Signaling	0.0574068150226033	-2.85759225408752	201	42	0.0247641509433962	1696	10287	23586,55706,23511,3133,8480,53371,3661,51447,23165,3105,5771,3662,23225,6672,9775,5300,57122,5781,9972,79902,818,81929,9830,81603,9631,1982,9636,3663,5595,3106,7726,3836,3840,3716,6233,6772,5371,23636,3838,6041,9818,8086	DDX58,NDC1,NUP188,HLA-E,RAE1,NUP54,IRF3,IP6K2,NUP205,HLA-A,PTPN2,IRF4,NUP210,SP100,EIF4A3,PIN1,NUP107,PTPN11,NUP153,NUP85,CAMK2G,SEH1L,TRIM14,TRIM8,NUP155,EIF4G2,ISG15,IRF5,MAPK3,HLA-B,TRIM26,KPNA1,KPNA4,JAK1,RPS27A,STAT1,PML,NUP62,KPNA2,RNASEL,NUP58,AAAS
R-HSA-1483257	Phospholipid metabolism	0.0596693424451224	-2.81893691736604	207	43	0.0253537735849057	1696	10287	51552,8760,10554,56910,1457,56894,1120,375,10423,253558,80230,5305,8895,23396,1119,25816,5728,9110,5296,9663,23446,5867,3032,5833,200576,79888,23171,8904,9489,79837,9107,50640,23760,6901,55361,8897,23646,10555,114882,254531,154141,56994,9791	RAB14,CDS2,AGPAT1,STARD7,CSNK2A1,AGPAT3,CHKB,ARF1,CDIPT,LCLAT1,RUFY1,PIP4K2A,CPNE3,PIP5K1C,CHKA,TNFAIP8,PTEN,MTMR4,PIK3R2,LPIN2,SLC44A1,RAB4A,HADHB,PCYT2,PIKFYVE,LPCAT1,GPD1L,CPNE1,PGS1,PIP4K2C,MTMR6,PNPLA8,PITPNB,TAZ,PI4K2A,MTMR3,PLD3,AGPAT2,OSBPL8,LPCAT4,MBOAT1,CHPT1,PTDSS1
R-HSA-6793080	rRNA modification in the mitochondrion	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	55178,387338,29960	MRM3,NSUN4,MRM2
R-HSA-390247	Beta-oxidation of very long chain fatty acids	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	215,1384,51	ABCD1,CRAT,ACOX1
R-HSA-176417	Phosphorylation of Emi1	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	5347,891,26271	PLK1,CCNB1,FBXO5
R-HSA-1482798	Acyl chain remodeling of CL	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	6901,253558,3032	TAZ,LCLAT1,HADHB
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	1666,34,3032	DECR1,ACADM,HADHB
R-HSA-444257	RSK activation	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	5170,5594,6195	PDPK1,MAPK1,RPS6KA1
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.0605099185452362	-2.80494798448604	6	3	0.0017688679245283	1696	10287	80319,1855,1856	CXXC4,DVL1,DVL2
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.0605631749572593	-2.80406824458815	229	47	0.0277122641509434	1696	10287	7249,27161,8454,84335,5715,4067,2309,5305,23396,805,7409,2261,5708,4193,5707,5687,6464,5728,5296,5781,84876,1027,1385,10768,64223,5170,80228,4893,143471,4690,208,79837,5695,5682,3845,5698,5691,5595,5704,5515,5525,6233,5714,5709,5594,5700,3265	TSC2,AGO2,CUL1,AKT1S1,PSMD9,LYN,FOXO3,PIP4K2A,PIP5K1C,CALM2,VAV1,FGFR3,PSMD2,MDM2,PSMD1,PSMA6,SHC1,PTEN,PIK3R2,PTPN11,ORAI1,CDKN1B,CREB1,AHCYL1,MLST8,PDPK1,ORAI2,NRAS,PSMA8,NCK1,AKT2,PIP4K2C,PSMB7,PSMA1,KRAS,PSMB9,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,RPS27A,PSMD8,PSMD3,MAPK1,PSMC1,HRAS
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.0609944084740766	-2.79697308336966	36	10	0.00589622641509434	1696	10287	5438,4087,5436,5441,5439,5440,5433,6774,4089,5430	POLR2I,SMAD2,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,STAT3,SMAD4,POLR2A
R-HSA-210993	Tie2 Signaling	0.0622494441953584	-2.7766056722658	18	6	0.0035377358490566	1696	10287	3845,4893,6464,3265,5296,5781	KRAS,NRAS,SHC1,HRAS,PIK3R2,PTPN11
R-HSA-180024	DARPP-32 events	0.0639772874390968	-2.74922714237272	27	8	0.00471698113207547	1696	10287	805,1020,5515,5530,5575,5534,5532,5566	CALM2,CDK5,PPP2CA,PPP3CA,PRKAR1B,PPP3R1,PPP3CB,PRKACA
R-HSA-3858494	Beta-catenin independent WNT signaling	0.0650226955734823	-2.73301890736064	149	32	0.0188679245283019	1696	10287	5530,387,143471,2788,27161,5879,5695,5682,5532,5715,5698,2783,5691,8323,5704,805,5708,5707,5687,6233,5714,81029,5709,5534,163,1855,1212,409,57154,5700,1175,1856	PPP3CA,RHOA,PSMA8,GNG7,AGO2,RAC1,PSMB7,PSMA1,PPP3CB,PSMD9,PSMB9,GNB2,PSMB3,FZD6,PSMC4,CALM2,PSMD2,PSMD1,PSMA6,RPS27A,PSMD8,WNT5B,PSMD3,PPP3R1,AP2B1,DVL1,CLTB,ARRB2,SMURF1,PSMC1,AP2S1,DVL2
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.0652945257573464	-2.72884707841377	46	12	0.00707547169811321	1696	10287	7323,892,8812,9612,4087,5933,6233,1874,7027,7029,4221,4089	UBE2D3,CCNC,CCNK,NCOR2,SMAD2,RBL1,RPS27A,E2F4,TFDP1,TFDP2,MEN1,SMAD4
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.0661830718464107	-2.715330561029	14	5	0.00294811320754717	1696	10287	6118,5111,6117,5395,4436	RPA2,PCNA,RPA1,PMS2,MSH2
R-HSA-5619115	Disorders of transmembrane transporters	0.066239983536156	-2.71447101745353	76	18	0.0106132075471698	1696	10287	143471,10613,5695,5682,5698,5715,5691,5704,79139,5708,5687,5707,6233,5709,5714,6400,5700,6048	PSMA8,ERLIN1,PSMB7,PSMA1,PSMB9,PSMD9,PSMB3,PSMC4,DERL1,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,SEL1L,PSMC1,RNF5
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	0.0663953138057916	-2.71212880020428	51	13	0.00766509433962264	1696	10287	5708,5707,5687,143471,5714,5709,5695,5682,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-111367	SLBP independent Processing of Histone Pre-mRNAs	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	6637,25888,6634,6628	SNRPG,ZNF473,SNRPD3,SNRPB
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	4350,4968,252969,8930	MPG,OGG1,NEIL2,MBD4
R-HSA-110056	MAPK3 (ERK1) activation	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	3716,3572,5595,5781	JAK1,IL6ST,MAPK3,PTPN11
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	1386,5594,1432,5595	ATF2,MAPK1,MAPK14,MAPK3
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	7159,7029,7027,1869	TP53BP2,TFDP2,TFDP1,E2F1
R-HSA-8853334	Signaling by FGFR3 fusions in cancer	0.0673142444759534	-2.69838340832404	10	4	0.00235849056603774	1696	10287	3845,2261,4893,3265	KRAS,FGFR3,NRAS,HRAS
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.0685892684750841	-2.67961919271098	32	9	0.00530660377358491	1696	10287	5515,1455,5525,8312,23401,4041,1855,1452,1856	PPP2CA,CSNK1G2,PPP2R5A,AXIN1,FRAT2,LRP5,DVL1,CSNK1A1,DVL2
R-HSA-73863	RNA Polymerase I Transcription Termination	0.0685892684750841	-2.67961919271098	32	9	0.00530660377358491	1696	10287	7343,84172,5441,5440,2966,10849,30834,7270,221830	UBTF,POLR1B,POLR2L,POLR2K,GTF2H2,CD3EAP,ZNRD1,TTF1,TWISTNB
R-HSA-166520	Signalling by NGF	0.0689350681240118	-2.67459025912357	477	91	0.0536556603773585	1696	10287	7249,4763,6195,5894,9500,5879,5566,1432,1399,805,7409,5906,4193,5707,5687,6464,5899,5296,115,1785,163,1027,10768,10126,64223,113,4893,26574,143471,9978,51107,208,5695,8452,5698,5515,5525,3716,6233,5714,5709,5536,409,5594,5700,1175,3066,7204,27161,7410,8649,8315,4205,84335,83464,5715,2309,5305,23396,5708,2261,156,5728,9138,11108,5781,9181,1385,6774,818,6709,5170,6868,387,7867,10276,5575,79837,5682,3845,23365,6016,2002,5605,5691,5595,5704,1845,1445,84078,3265	TSC2,NF1,RPS6KA1,RAF1,MAGED1,RAC1,PRKACA,MAPK14,CRKL,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,RALB,PIK3R2,ADCY9,DNM2,AP2B1,CDKN1B,AHCYL1,DNAL4,MLST8,ADCY7,NRAS,AATF,PSMA8,RBX1,APH1A,AKT2,PSMB7,CUL3,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,AP2S1,HDAC2,TRIO,AGO2,VAV2,LAMTOR3,BRAP,MEF2A,AKT1S1,APH1B,PSMD9,FOXO3,PIP4K2A,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,ARHGEF1,PRDM4,PTPN11,ARHGEF2,CREB1,STAT3,CAMK2G,SPTAN1,PDPK1,ADAM17,RHOA,MAPKAPK3,NET1,PRKAR1B,PIP4K2C,PSMA1,KRAS,ARHGEF12,RIT1,ELK1,MAP2K2,PSMB3,MAPK3,PSMC4,DUSP3,CSK,KBTBD7,HRAS
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	0.0711708621537473	-2.64267178373917	23	7	0.00412735849056604	1696	10287	9804,10452,7416,81631,6233,100188893,9927	TOMM20,TOMM40,VDAC1,MAP1LC3B,RPS27A,TOMM6,MFN2
R-HSA-5627123	RHO GTPases activate PAKs	0.0711708621537473	-2.64267178373917	23	7	0.00412735849056604	1696	10287	4627,805,4659,998,3984,103910,5879	MYH9,CALM2,PPP1R12A,CDC42,LIMK1,MYL12B,RAC1
R-HSA-5205647	Mitophagy	0.0711708621537473	-2.64267178373917	23	7	0.00412735849056604	1696	10287	9804,10452,7416,81631,6233,100188893,9927	TOMM20,TOMM40,VDAC1,MAP1LC3B,RPS27A,TOMM6,MFN2
R-HSA-351202	Metabolism of polyamines	0.0715749524590497	-2.63701009220985	87	20	0.0117924528301887	1696	10287	6723,1728,143471,84245,262,5695,5682,4953,5698,5715,5691,5704,5708,5687,5707,5709,5714,4947,5700,4946	SRM,NQO1,PSMA8,MRI1,AMD1,PSMB7,PSMA1,ODC1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,PSMD3,PSMD8,OAZ2,PSMC1,OAZ1
R-HSA-5689896	Ovarian tumor domain proteases	0.0717439112370458	-2.63465228875101	37	10	0.00589622641509434	1696	10287	23586,55593,387,7128,5728,6233,23252,57506,84282,54764	DDX58,OTUD5,RHOA,TNFAIP3,PTEN,RPS27A,OTUD3,MAVS,RNF135,ZRANB1
R-HSA-1483206	Glycerophospholipid biosynthesis	0.0719375256954972	-2.63195723530813	129	28	0.0165094339622642	1696	10287	8904,8760,9489,10554,56910,1457,56894,1120,23760,50640,10423,6901,253558,8895,1119,23646,10555,114882,23446,9663,254531,3032,154141,5833,56994,79888,23171,9791	CPNE1,CDS2,PGS1,AGPAT1,STARD7,CSNK2A1,AGPAT3,CHKB,PITPNB,PNPLA8,CDIPT,TAZ,LCLAT1,CPNE3,CHKA,PLD3,AGPAT2,OSBPL8,SLC44A1,LPIN2,LPCAT4,HADHB,MBOAT1,PCYT2,CHPT1,LPCAT1,GPD1L,PTDSS1
R-HSA-5653890	Lactose synthesis	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	2683,6513	B4GALT1,SLC2A1
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	4350,4968	MPG,OGG1
R-HSA-77108	Utilization of Ketone Bodies	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	38,622	ACAT1,BDH1
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	4087,4089	SMAD2,SMAD4
R-HSA-844455	The NLRP1 inflammasome	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	596,598	BCL2,BCL2L1
R-HSA-110331	Cleavage of the damaged purine	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	4350,4968	MPG,OGG1
R-HSA-352238	Breakdown of the nuclear lamina	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	839,4000	CASP6,LMNA
R-HSA-5688031	Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	7270,29080	TTF1,CCDC59
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	4087,4089	SMAD2,SMAD4
R-HSA-73927	Depurination	0.072554979229454	-2.62341067031224	3	2	0.00117924528301887	1696	10287	4350,4968	MPG,OGG1
R-HSA-167172	Transcription of the HIV genome	0.0736903132128588	-2.60788392380028	77	18	0.0106132075471698	1696	10287	9150,5438,5436,5441,5440,6924,5433,5430,2962,11198,8812,6873,5439,6883,6917,6878,2966,6749	CTDP1,POLR2I,POLR2G,POLR2L,POLR2K,ELOA,POLR2D,POLR2A,GTF2F1,SUPT16H,CCNK,TAF2,POLR2J,TAF12,TCEA1,TAF6,GTF2H2,SSRP1
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5436,5441,5439,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-73776	RNA Polymerase II Promoter Escape	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5436,5441,5439,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-167161	HIV Transcription Initiation	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5439,5436,5441,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5436,5441,5439,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5436,5441,5439,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.0750871564156352	-2.58910575460277	47	12	0.00707547169811321	1696	10287	6873,5438,5439,5436,5441,5440,5433,6883,2966,6878,5430,2962	TAF2,POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,TAF12,GTF2H2,TAF6,POLR2A,GTF2F1
R-HSA-4608870	Asymmetric localization of PCP proteins	0.0752554499907635	-2.5868669528493	67	16	0.00943396226415094	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,5698,57154,5715,5700,5691,1856,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,PSMB9,SMURF1,PSMD9,PSMC1,PSMB3,DVL2,PSMC4
R-HSA-71291	Metabolism of amino acids and derivatives	0.0768062310652379	-2.56646950845772	361	70	0.0412735849056604	1696	10287	6723,3735,1728,6181,56922,2746,4942,6135,6147,587,5707,5687,3376,2806,51520,6159,11224,143471,6169,5695,4967,4953,5698,8050,6203,3921,6167,6233,5714,6208,5709,6176,55526,2197,5700,6231,4946,2730,6209,6187,84890,84245,6138,79048,5715,5708,6139,191,6143,27034,5832,200916,223,262,6132,6128,6204,5682,6229,6157,4548,5691,25873,5704,2058,6161,5859,4947,38,2653	SRM,KARS,NQO1,RPLP2,MCCC1,GLUD1,OAT,RPL11,RPL23A,BCAT2,PSMD1,PSMA6,IARS,GOT2,LARS,RPL29,RPL35,PSMA8,RPL38,PSMB7,OGDH,ODC1,PSMB9,PDHX,RPS9,RPSA,RPL37,RPS27A,PSMD8,RPS14,PSMD3,RPLP1,DHTKD1,FAU,PSMC1,RPS26,OAZ1,GCLM,RPS15,RPS2,ADO,MRI1,RPL15,SECISBP2,PSMD9,PSMD2,RPL17,AHCY,RPL19,ACAD8,ALDH18A1,RPL22L1,ALDH9A1,AMD1,RPL8,RPL6,RPS10,PSMA1,RPS24,RPL27A,MTR,PSMB3,RPL36,PSMC4,EPRS,RPL32,QARS,OAZ2,ACAT1,GCSH
R-HSA-1483191	Synthesis of PC	0.0771539037426678	-2.56195310206658	28	8	0.00471698113207547	1696	10287	1457,1120,56994,79888,9663,23446,1119,56910	CSNK2A1,CHKB,CHPT1,LPCAT1,LPIN2,SLC44A1,CHKA,STARD7
R-HSA-70268	Pyruvate metabolism	0.0771539037426678	-2.56195310206658	28	8	0.00471698113207547	1696	10287	6566,5164,2739,3029,8050,51660,3945,3939	SLC16A1,PDK2,GLO1,HAGH,PDHX,MPC1,LDHB,LDHA
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	0.0771539037426678	-2.56195310206658	28	8	0.00471698113207547	1696	10287	9500,1612,148022,26060,8772,1613,355,8837	MAGED1,DAPK1,TICAM1,APPL1,FADD,DAPK3,FAS,CFLAR
R-HSA-437239	Recycling pathway of L1	0.0771539037426678	-2.56195310206658	28	8	0.00471698113207547	1696	10287	1808,6195,1785,163,7430,5594,1175,8650	DPYSL2,RPS6KA1,DNM2,AP2B1,EZR,MAPK1,AP2S1,NUMB
R-HSA-1638074	Keratan sulfate/keratin metabolism	0.0811037948694523	-2.51202552648384	33	9	0.00530660377358491	1696	10287	2799,9334,3074,2683,6483,8703,8702,3073,8704	GNS,B4GALT5,HEXB,B4GALT1,ST3GAL2,B4GALT3,B4GALT4,HEXA,B4GALT2
R-HSA-1980145	Signaling by NOTCH2	0.0811037948694523	-2.51202552648384	33	9	0.00530660377358491	1696	10287	142678,102,51107,6233,4853,3516,1385,9794,83464	MIB2,ADAM10,APH1A,RPS27A,NOTCH2,RBPJ,CREB1,MAML1,APH1B
R-HSA-5357905	Regulation of TNFR1 signaling	0.0811037948694523	-2.51202552648384	33	9	0.00530660377358491	1696	10287	1540,7128,330,6233,331,27005,329,56928,84888	CYLD,TNFAIP3,BIRC3,RPS27A,XIAP,USP21,BIRC2,SPPL2B,SPPL2A
R-HSA-389356	CD28 co-stimulation	0.0811037948694523	-2.51202552648384	33	9	0.00530660377358491	1696	10287	5170,7409,998,208,5296,5879,9020,4067,64223	PDPK1,VAV1,CDC42,AKT2,PIK3R2,RAC1,MAP3K14,LYN,MLST8
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.0836121113839667	-2.48156689637061	38	10	0.00589622641509434	1696	10287	6118,2067,5983,116028,7156,672,641,5982,80010,6117	RPA2,ERCC1,RFC3,RMI2,TOP3A,BRCA1,BLM,RFC2,RMI1,RPA1
R-HSA-166054	Activated TLR4 signalling	0.0840812184172497	-2.47597206135229	115	25	0.0147405660377358	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1845,6233,23118,10010,5781,148022,1385,1386,5594	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,DUSP3,RPS27A,TAB2,TANK,PTPN11,TICAM1,CREB1,ATF2,MAPK1
R-HSA-5655253	Signaling by FGFR2 in disease	0.0850759426907076	-2.46421097795473	43	11	0.00648584905660377	1696	10287	5438,4893,5439,5436,5441,5440,5433,3845,3265,5430,2962	POLR2I,NRAS,POLR2J,POLR2G,POLR2L,POLR2K,POLR2D,KRAS,HRAS,POLR2A,GTF2F1
R-HSA-75153	Apoptotic execution  phase	0.0858869799020999	-2.45472303421481	53	13	0.00766509433962264	1696	10287	2339,3836,118,63967,839,3148,5339,6093,2620,10134,329,4000,6709	FNTA,KPNA1,ADD1,CLSPN,CASP6,HMGB2,PLEC,ROCK1,GAS2,BCAP31,BIRC2,LMNA,SPTAN1
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.086286295568968	-2.45008449339888	15	5	0.00294811320754717	1696	10287	5347,9493,9126,10726,23047	PLK1,KIF23,SMC3,NUDC,PDS5B
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.086286295568968	-2.45008449339888	15	5	0.00294811320754717	1696	10287	596,7534,7533,208,5534	BCL2,YWHAZ,YWHAH,AKT2,PPP3R1
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.086286295568968	-2.45008449339888	15	5	0.00294811320754717	1696	10287	163,1212,409,1175,1856	AP2B1,CLTB,ARRB2,AP2S1,DVL2
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.0867766231595389	-2.44441801202705	24	7	0.00412735849056604	1696	10287	6118,5111,5983,5426,5982,8505,6117	RPA2,PCNA,RFC3,POLE,RFC2,PARG,RPA1
R-HSA-211000	Gene Silencing by RNA	0.0881877985739772	-2.42828666370252	137	29	0.0170990566037736	1696	10287	55706,5438,3015,23511,5436,5441,5440,8480,27161,53371,5433,9631,8575,94239,23165,5430,23225,5439,54487,57122,3014,23636,9972,3020,4603,79902,9818,8086,81929	NDC1,POLR2I,H2AFZ,NUP188,POLR2G,POLR2L,POLR2K,RAE1,AGO2,NUP54,POLR2D,NUP155,PRKRA,H2AFV,NUP205,POLR2A,NUP210,POLR2J,DGCR8,NUP107,H2AFX,NUP62,NUP153,H3F3A,MYBL1,NUP85,NUP58,AAAS,SEH1L
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.0891800523373824	-2.41709789290944	197	40	0.0235849056603774	1696	10287	7249,27161,8454,84335,5715,2309,5305,23396,7409,2261,5708,4193,5707,5687,5728,5296,5781,1027,1385,64223,5170,4893,143471,208,79837,5695,5682,3845,5698,5691,5595,5704,5515,5525,6233,5709,5714,5594,5700,3265	TSC2,AGO2,CUL1,AKT1S1,PSMD9,FOXO3,PIP4K2A,PIP5K1C,VAV1,FGFR3,PSMD2,MDM2,PSMD1,PSMA6,PTEN,PIK3R2,PTPN11,CDKN1B,CREB1,MLST8,PDPK1,NRAS,PSMA8,AKT2,PIP4K2C,PSMB7,PSMA1,KRAS,PSMB9,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,RPS27A,PSMD3,PSMD8,MAPK1,PSMC1,HRAS
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.0918319787105887	-2.38779469004895	29	8	0.00471698113207547	1696	10287	5438,5436,5441,5439,5440,5433,4603,5430	POLR2I,POLR2G,POLR2L,POLR2J,POLR2K,POLR2D,MYBL1,POLR2A
R-HSA-442742	CREB phosphorylation through the activation of Ras	0.0918319787105887	-2.38779469004895	29	8	0.00471698113207547	1696	10287	5170,805,1385,5594,6195,3265,5894,818	PDPK1,CALM2,CREB1,MAPK1,RPS6KA1,HRAS,RAF1,CAMK2G
R-HSA-5617833	Cilium Assembly	0.0918760961812333	-2.387314390296	192	39	0.0229952830188679	1696	10287	11336,9371,11116,261734,22919,8655,10540,54930,5566,11020,8766,55142,23059,4218,9738,55835,22920,6102,80254,56912,1639,5347,10576,255758,51259,117177,10694,378,166379,93323,5108,51668,4957,60412,8636,5311,54820,203068,1453	EXOC3,KIF3B,FGFR1OP,NPHP4,MAPRE1,DYNLL1,DCTN2,HAUS4,PRKACA,IFT27,RAB11A,HAUS2,CLUAP1,RAB8A,CCP110,CENPJ,KIFAP3,RP2,CEP63,IFT46,DCTN1,PLK1,CCT2,TCTEX1D2,TMEM216,RAB3IP,CCT8,ARF4,BBS12,HAUS8,PCM1,HSPB11,ODF2,EXOC4,SSNA1,PKD2,NDE1,TUBB,CSNK1D
R-HSA-73614	Pyrimidine salvage reactions	0.0924179573867313	-2.38143397520461	11	4	0.00235849056603774	1696	10287	83549,7083,1633,7371	UCK1,TK1,DCK,UCK2
R-HSA-8851805	MET activates RAS signaling	0.0924179573867313	-2.38143397520461	11	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.0924179573867313	-2.38143397520461	11	4	0.00235849056603774	1696	10287	25974,4594,4548,51293	MMACHC,MUT,MTR,CD320
R-HSA-418889	Ligand-independent caspase activation via DCC	0.0924179573867313	-2.38143397520461	11	4	0.00235849056603774	1696	10287	26060,9500,1613,1612	APPL1,MAGED1,DAPK3,DAPK1
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.0931940778488276	-2.37307110170405	7	3	0.0017688679245283	1696	10287	7040,4087,4089	TGFB1,SMAD2,SMAD4
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.0931940778488276	-2.37307110170405	7	3	0.0017688679245283	1696	10287	7040,4087,4089	TGFB1,SMAD2,SMAD4
R-HSA-433692	Proton-coupled monocarboxylate transport	0.0931940778488276	-2.37307110170405	7	3	0.0017688679245283	1696	10287	6566,133418,9194	SLC16A1,EMB,SLC16A7
R-HSA-164843	2-LTR circle formation	0.0931940778488276	-2.37307110170405	7	3	0.0017688679245283	1696	10287	7518,8815,7520	XRCC4,BANF1,XRCC5
R-HSA-6806834	Signaling by MET	0.0934129720344324	-2.37072505651294	69	16	0.00943396226415094	1696	10287	4893,5879,3845,8027,5771,1399,64759,9146,5906,6464,6233,5867,5781,3688,6774,3265	NRAS,RAC1,KRAS,STAM,PTPN2,CRKL,TNS3,HGS,RAP1A,SHC1,RPS27A,RAB4A,PTPN11,ITGB1,STAT3,HRAS
R-HSA-450294	MAP kinase activation in TLR cascade	0.0947952606623106	-2.35603586398445	64	15	0.00884433962264151	1696	10287	5515,1845,7867,23118,6233,6195,8454,4205,7335,1385,2002,1386,5594,1432,5595	PPP2CA,DUSP3,MAPKAPK3,TAB2,RPS27A,RPS6KA1,CUL1,MEF2A,UBE2V1,CREB1,ELK1,ATF2,MAPK1,MAPK14,MAPK3
R-HSA-504046	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.0959858625142724	-2.34355436383525	149	31	0.0182783018867925	1696	10287	112495,3015,5441,2648,7978,5440,9219,84265,2971,94239,53615,7270,6621,51728,221830,5595,11335,7343,54700,1107,10849,9112,8932,3014,27297,84172,3020,5928,2966,30834,3066	GTF3C6,H2AFZ,POLR2L,KAT2A,MTERF1,POLR2K,MTA2,POLR3GL,GTF3A,H2AFV,MBD3,TTF1,SNAPC4,POLR3K,TWISTNB,MAPK3,CBX3,UBTF,RRN3,CHD3,CD3EAP,MTA1,MBD2,H2AFX,CRCP,POLR1B,H3F3A,RBBP4,GTF2H2,ZNRD1,HDAC2
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0974945027521672	-2.32795928459692	20	6	0.0035377358490566	1696	10287	3845,4893,6464,6233,3265,11140	KRAS,NRAS,SHC1,RPS27A,HRAS,CDC37
R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.0974945027521672	-2.32795928459692	20	6	0.0035377358490566	1696	10287	4193,11200,6233,387893,133746,79813	MDM2,CHEK2,RPS27A,KMT5A,JMY,EHMT1
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0974945027521672	-2.32795928459692	20	6	0.0035377358490566	1696	10287	3845,4893,6464,6233,3265,11140	KRAS,NRAS,SHC1,RPS27A,HRAS,CDC37
R-HSA-1643713	Signaling by EGFR in Cancer	0.0974945027521672	-2.32795928459692	20	6	0.0035377358490566	1696	10287	3845,4893,6464,6233,3265,11140	KRAS,NRAS,SHC1,RPS27A,HRAS,CDC37
R-HSA-73864	RNA Polymerase I Transcription	0.101325304786529	-2.28941909846312	112	24	0.0141509433962264	1696	10287	3015,5441,2648,5440,9219,94239,53615,7270,221830,5595,11335,7343,54700,1107,10849,8932,9112,3014,84172,3020,5928,2966,30834,3066	H2AFZ,POLR2L,KAT2A,POLR2K,MTA2,H2AFV,MBD3,TTF1,TWISTNB,MAPK3,CBX3,UBTF,RRN3,CHD3,CD3EAP,MBD2,MTA1,H2AFX,POLR1B,H3F3A,RBBP4,GTF2H2,ZNRD1,HDAC2
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.104159947707458	-2.26182760256254	25	7	0.00412735849056604	1696	10287	22872,3106,6891,3133,9632,3105,6890	SEC31A,HLA-B,TAP2,HLA-E,SEC24C,HLA-A,TAP1
R-HSA-111996	Ca-dependent events	0.107996488770861	-2.22565656376734	30	8	0.00471698113207547	1696	10287	805,156,115,5575,1385,5594,5566,113	CALM2,GRK2,ADCY9,PRKAR1B,CREB1,MAPK1,PRKACA,ADCY7
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.109186911907554	-2.21469407718087	16	5	0.00294811320754717	1696	10287	3845,4893,6464,3265,11140	KRAS,NRAS,SHC1,HRAS,CDC37
R-HSA-163210	Formation of ATP by chemiosmotic coupling	0.109186911907554	-2.21469407718087	16	5	0.00294811320754717	1696	10287	498,506,9551,518,522	ATP5F1A,ATP5F1B,ATP5MF,ATP5MC3,ATP5PF
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.109186911907554	-2.21469407718087	16	5	0.00294811320754717	1696	10287	23586,80143,3661,57506,84282	DDX58,SIKE1,IRF3,MAVS,RNF135
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.109186911907554	-2.21469407718087	16	5	0.00294811320754717	1696	10287	3845,4893,6464,3265,11140	KRAS,NRAS,SHC1,HRAS,CDC37
R-HSA-186763	Downstream signal transduction	0.109288242875194	-2.2137664570585	352	67	0.0395047169811321	1696	10287	7249,4763,5894,5566,1399,805,7409,5906,4193,5707,5687,6464,5296,115,1027,10768,64223,113,4893,143471,9978,4690,208,8452,5695,5698,5515,5525,3716,6233,5714,6778,5709,6772,5536,409,5594,5700,27161,8649,8315,84335,5715,5305,2309,23396,5708,2261,156,5728,5781,1385,6774,818,6709,5170,79837,5575,5682,3845,5605,5691,5595,5704,1445,84078,3265	TSC2,NF1,RAF1,PRKACA,CRKL,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,ADCY9,CDKN1B,AHCYL1,MLST8,ADCY7,NRAS,PSMA8,RBX1,NCK1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,STAT6,PSMD3,STAT1,PPP5C,ARRB2,MAPK1,PSMC1,AGO2,LAMTOR3,BRAP,AKT1S1,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,STAT3,CAMK2G,SPTAN1,PDPK1,PIP4K2C,PRKAR1B,PSMA1,KRAS,MAP2K2,PSMB3,MAPK3,PSMC4,CSK,KBTBD7,HRAS
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.109823197550803	-2.20888350126678	50	12	0.00707547169811321	1696	10287	8897,51552,5728,5296,5867,79837,9107,375,80230,5305,23396,55361	MTMR3,RAB14,PTEN,PIK3R2,RAB4A,PIP4K2C,MTMR6,ARF1,RUFY1,PIP4K2A,PIP5K1C,PI4K2A
R-HSA-6802949	Signaling by RAS mutants	0.109823197550803	-2.20888350126678	50	12	0.00707547169811321	1696	10287	5906,4893,1445,4763,5894,8315,3845,5594,409,3265,5605,5595	RAP1A,NRAS,CSK,NF1,RAF1,BRAP,KRAS,MAPK1,ARRB2,HRAS,MAP2K2,MAPK3
R-HSA-177929	Signaling by EGFR	0.112321131876964	-2.18639326150324	364	69	0.0406839622641509	1696	10287	7249,102,4763,5894,5566,8027,805,7409,5906,4193,5707,5687,6464,998,5296,115,1027,10768,64223,113,5796,4893,143471,9978,208,8452,5695,5698,5515,5525,3716,6233,5714,5709,5536,409,5594,5700,27161,8649,29924,8315,84335,5715,5305,2309,23396,5708,2261,156,5728,5781,1385,818,6709,5170,6868,5575,79837,5682,3845,5605,5691,5595,5704,9146,1445,84078,3265	TSC2,ADAM10,NF1,RAF1,PRKACA,STAM,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,CDC42,PIK3R2,ADCY9,CDKN1B,AHCYL1,MLST8,ADCY7,PTPRK,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,AGO2,LAMTOR3,EPN1,BRAP,AKT1S1,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,CAMK2G,SPTAN1,PDPK1,ADAM17,PRKAR1B,PIP4K2C,PSMA1,KRAS,MAP2K2,PSMB3,MAPK3,PSMC4,HGS,CSK,KBTBD7,HRAS
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.118354130111058	-2.13407404619921	21	6	0.0035377358490566	1696	10287	6118,5111,5983,5426,5982,6117	RPA2,PCNA,RFC3,POLE,RFC2,RPA1
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.118354130111058	-2.13407404619921	21	6	0.0035377358490566	1696	10287	142678,4853,102,51107,83464,6233	MIB2,NOTCH2,ADAM10,APH1A,APH1B,RPS27A
R-HSA-176974	Unwinding of DNA	0.12125204881343	-2.10988385187695	12	4	0.00235849056603774	1696	10287	9837,4171,4174,84296	GINS1,MCM2,MCM5,GINS4
R-HSA-73886	Chromosome Maintenance	0.121598931879857	-2.1070270933714	109	23	0.013561320754717	1696	10287	23649,5983,3015,55355,5558,5982,94239,79682,6117,5557,54386,6118,11339,5111,5426,3014,80152,79019,10856,5928,7013,25913,7014	POLA2,RFC3,H2AFZ,HJURP,PRIM2,RFC2,H2AFV,CENPU,RPA1,PRIM1,TERF2IP,RPA2,OIP5,PCNA,POLE,H2AFX,CENPT,CENPM,RUVBL2,RBBP4,TERF1,POT1,TERF2
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	0.123268160088791	-2.09339313339373	26	7	0.00412735849056604	1696	10287	1540,7128,330,23118,329,27005,331	CYLD,TNFAIP3,BIRC3,TAB2,BIRC2,USP21,XIAP
R-HSA-5654743	Signaling by FGFR4	0.125930658546406	-2.07202385251402	41	10	0.00589622641509434	1696	10287	5515,8569,4893,6464,6233,5781,3845,5594,3265,5595	PPP2CA,MKNK1,NRAS,SHC1,RPS27A,PTPN11,KRAS,MAPK1,HRAS,MAPK3
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.128042041586889	-2.05539661909281	126	26	0.0153301886792453	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1845,6233,23118,10010,5781,1785,148022,1385,1386,5594	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,DUSP3,RPS27A,TAB2,TANK,PTPN11,DNM2,TICAM1,CREB1,ATF2,MAPK1
R-HSA-8847453	Synthesis of PIPs in the nucleus	0.129420898510753	-2.04468540678128	4	2	0.00117924528301887	1696	10287	5305,79837	PIP4K2A,PIP4K2C
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	0.129420898510753	-2.04468540678128	4	2	0.00117924528301887	1696	10287	1984,1725	EIF5A,DHPS
R-HSA-4551638	SUMOylation of chromatin organization proteins	0.129420898510753	-2.04468540678128	4	2	0.00117924528301887	1696	10287	7329,6613	UBE2I,SUMO2
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.129420898510753	-2.04468540678128	4	2	0.00117924528301887	1696	10287	5925,1017	RB1,CDK2
R-HSA-165158	Activation of AKT2	0.129420898510753	-2.04468540678128	4	2	0.00117924528301887	1696	10287	5170,208	PDPK1,AKT2
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.130951802971711	-2.03292593972526	110	23	0.013561320754717	1696	10287	3015,5441,2648,5440,9219,94239,53615,7270,221830,5595,7343,54700,1107,10849,8932,9112,3014,84172,3020,5928,2966,30834,3066	H2AFZ,POLR2L,KAT2A,POLR2K,MTA2,H2AFV,MBD3,TTF1,TWISTNB,MAPK3,UBTF,RRN3,CHD3,CD3EAP,MBD2,MTA1,H2AFX,POLR1B,H3F3A,RBBP4,GTF2H2,ZNRD1,HDAC2
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	2280,7040,4087	FKBP1A,TGFB1,SMAD2
R-HSA-73928	Depyrimidination	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	4968,252969,8930	OGG1,NEIL2,MBD4
R-HSA-110329	Cleavage of the damaged pyrimidine	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	4968,252969,8930	OGG1,NEIL2,MBD4
R-HSA-77111	Synthesis of Ketone Bodies	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	38,65985,622	ACAT1,AACS,BDH1
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	2280,7040,4087	FKBP1A,TGFB1,SMAD2
R-HSA-1483148	Synthesis of PG	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	23646,8760,9489	PLD3,CDS2,PGS1
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	4968,252969,8930	OGG1,NEIL2,MBD4
R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	0.131416103751275	-2.02938662525616	8	3	0.0017688679245283	1696	10287	51005,64841,6675	AMDHD2,GNPNAT1,UAP1
R-HSA-112399	IRS-mediated signalling	0.13193470921055	-2.02544810595695	294	56	0.0330188679245283	1696	10287	5564,7249,4763,5894,5562,8649,8315,64121,84335,5715,29904,805,2261,5708,5906,5707,5687,6464,5296,5781,818,64223,6709,5170,4893,143471,9978,208,8452,5695,5682,3845,5140,5698,5605,5691,6009,5595,5704,5515,7248,5525,3716,1445,6233,5714,5709,389541,84078,51719,6794,5536,409,5594,5700,3265	PRKAB1,TSC2,NF1,RAF1,PRKAA1,LAMTOR3,BRAP,RRAGC,AKT1S1,PSMD9,EEF2K,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,PDE3B,PSMB9,MAP2K2,PSMB3,RHEB,MAPK3,PSMC4,PPP2CA,TSC1,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,LAMTOR4,KBTBD7,CAB39,STK11,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.133590554912504	-2.01297571714142	78	17	0.0100235849056604	1696	10287	55907,64841,7264,8813,10020,26503,51005,54187,4758,10195,116150,6675,6483,5476,8128,140838,10559	CMAS,GNPNAT1,TSTA3,DPM1,GNE,SLC17A5,AMDHD2,NANS,NEU1,ALG3,NUS1,UAP1,ST3GAL2,CTSA,ST8SIA2,NANP,SLC35A1
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.134590081940422	-2.00552154992162	57	13	0.00766509433962264	1696	10287	2512,6643,8907,1785,1174,10618,375,162,23431,1176,8301,7037,23557	FTL,SNX2,AP1M1,DNM2,AP1S1,TGOLN2,ARF1,AP1B1,AP4E1,AP3S1,PICALM,TFRC,SNAPIN
R-HSA-111931	PKA-mediated phosphorylation of CREB	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	1385,5566,115,5575,113	CREB1,PRKACA,ADCY9,PRKAR1B,ADCY7
R-HSA-196299	Beta-catenin phosphorylation cascade	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	5515,23401,5525,1452,8312	PPP2CA,FRAT2,PPP2R5A,CSNK1A1,AXIN1
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	5393,118460,23016,115024,51013	EXOSC9,EXOSC6,EXOSC7,NT5C3B,EXOSC1
R-HSA-164378	PKA activation in glucagon signalling	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	2778,5566,115,5575,113	GNAS,PRKACA,ADCY9,PRKAR1B,ADCY7
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	25974,4594,4548,51293,56922	MMACHC,MUT,MTR,CD320,MCCC1
R-HSA-432142	Platelet sensitization by LDL	0.1346939755752	-2.00474992132324	17	5	0.00294811320754717	1696	10287	5515,5525,1432,7804,5781	PPP2CA,PPP2R5A,MAPK14,LRP8,PTPN11
R-HSA-1430728	Metabolism	0.137848750879454	-1.98159820300095	2158	373	0.219929245283019	1696	10287	51552,79717,7295,23511,4712,29801,3074,10554,2746,2992,4942,51312,6147,805,5707,606495,5867,1785,163,8801,9972,1836,171546,81929,2788,292,55974,58526,6233,5714,6208,23417,55526,9377,7388,6483,54480,4946,5214,8086,8704,1329,4729,4594,84890,64781,6240,2683,4697,54205,4125,5715,374291,4724,2799,137682,3632,471,622,1503,5833,1537,200576,2771,79888,5261,79902,5464,2222,9489,6204,79837,6229,1635,5315,4548,5691,1528,55361,51109,159,847,2058,10797,1633,5859,51586,47,254531,4190,2821,55627,3073,9818,80221,11165,3735,55706,1728,7389,56910,83440,347734,5566,253558,6389,2783,8895,51293,7957,390916,80308,1666,23683,9110,1854,115,9663,57122,6888,23171,2879,113,8904,3419,6169,5209,4701,6901,5698,4144,5515,221,253782,27068,6176,154141,8566,8703,7804,2584,9612,6187,4719,4126,9334,84245,7086,8604,56894,79048,84836,51447,506,6697,10654,23396,10682,27430,5708,4695,5728,4710,6139,1384,6143,4696,200916,10499,3613,6837,3945,7083,2987,2581,55863,143,6132,3939,158,6157,153642,23646,6573,6448,6161,518,51,4947,1622,10128,128240,60386,4725,23179,5660,84875,57488,6723,892,1355,57128,375790,10007,29796,56922,1457,10423,80230,522,587,5906,23225,2806,5296,23446,60490,3032,231,4715,9524,10498,10057,51520,6241,25870,23344,23760,4953,51660,51099,6167,10555,4669,79777,6794,200895,55190,56994,5700,6231,83930,6209,6383,23389,427,6138,1327,9967,8702,2053,23165,1119,6945,112950,84246,191,51228,27034,5832,223,4363,65985,50814,4835,11163,262,2181,2629,6128,5682,79001,5704,25873,6390,2778,29095,5634,9167,6566,23636,5476,498,9791,57107,4698,25974,7360,6181,8802,91942,4191,6513,7371,83549,1120,9453,2132,6135,5164,4899,5687,25816,3376,1431,51706,9562,10768,2760,11261,51703,6159,11224,143471,5538,80219,1371,5695,9107,2739,9631,4967,4707,6203,8050,3921,5445,22937,5709,126328,406,8648,949,2197,4048,1175,19,2730,55191,8760,8480,53371,285362,494143,375,5305,373156,4723,2618,9632,215,4728,10728,6576,271,126792,1455,60481,51300,5575,50640,9551,3029,4758,8897,114882,1351,3614,38,34,3420,5223,2653	RAB14,PPCS,TXN,NUP188,NDUFB6,ZDHHC8,HEXB,AGPAT1,GLUD1,GYG1,OAT,SLC25A37,RPL23A,CALM2,PSMD1,CYB5RL,RAB4A,DNM2,AP2B1,SUCLG2,NUP153,SLC26A2,SPTSSA,SEH1L,GNG7,SLC25A5,SLC50A1,MID1IP1,RPS27A,PSMD8,RPS14,MLYCD,DHTKD1,COX5A,UQCRH,ST3GAL2,CHPF2,OAZ1,PFKP,AAAS,B4GALT2,COX5B,NDUFV2,MUT,ADO,CERK,RRM1,B4GALT1,NDUFA4,CYCS,MAN2B1,PSMD9,NDUFS7,NDUFS4,GNS,NDUFAF6,INPP5A,ATIC,BDH1,CTPS1,PCYT2,CYC1,PIKFYVE,GNAI2,LPCAT1,PHKG2,NUP85,PPA1,FDFT1,PGS1,RPS10,PIP4K2C,RPS24,DCTD,PKM,MTR,PSMB3,CYB5A,PI4K2A,RDH11,ADSS,CAT,EPRS,MTHFD2,DCK,QARS,MED15,ACLY,LPCAT4,MDH1,GPI,SMPD4,HEXA,NUP58,ACSF2,NUDT3,KARS,NDC1,NQO1,UROD,STARD7,ADPGK,SLC35B2,PRKACA,LCLAT1,SDHA,GNB2,CPNE3,CD320,EPM2A,NUDT19,FLAD1,DECR1,PRKD3,MTMR4,DUT,ADCY9,LPIN2,NUP107,TALDO1,GPD1L,GPX4,ADCY7,CPNE1,IDH3A,RPL38,PFKFB3,NDUFA7,TAZ,PSMB9,MAT2A,PPP2CA,ALDH3B1,CERS6,PPA2,RPLP1,MBOAT1,PDXK,B4GALT3,LRP8,GALK1,NCOR2,RPS2,NDUFS1,MANBA,B4GALT5,MRI1,TKT,SLC25A12,AGPAT3,SECISBP2,ABHD14B,IP6K2,ATP5F1B,SPR,PMVK,PIP5K1C,EBP,MAT2B,PSMD2,NDUFA2,PTEN,NDUFB4,RPL17,CRAT,RPL19,NDUFA3,RPL22L1,NCOA2,IMPA2,MED22,LDHB,TK1,GUK1,GALC,TMEM126B,PARP4,RPL8,LDHA,ADSL,RPL27A,ARSK,PLD3,SLC19A1,SGSH,RPL32,ATP5MC3,ACOX1,OAZ2,DBI,LRPPRC,NAXE,SLC25A19,NDUFS5,RGL1,PSAP,PARP10,ESYT2,SRM,CCNC,COX15,LYRM4,AGRN,GNPDA1,UQCR10,MCCC1,CSNK2A1,CDIPT,RUFY1,ATP5PF,BCAT2,RAP1A,NUP210,GOT2,PIK3R2,SLC44A1,PPCDC,HADHB,AKR1B1,NDUFB9,TECR,CARM1,ABCC5,LARS,RRM2,SUMF2,ESYT1,PITPNB,ODC1,MPC1,ABHD5,RPL37,AGPAT2,NAGLU,ACBD4,STK11,DHFR2,NUDT11,CHPT1,PSMC1,RPS26,STARD3NL,RPS15,SDC2,MED13L,ASAH1,RPL15,COX4I1,THRAP3,B4GALT4,EPHX2,NUP205,CHKA,MLX,MED8,MED10,AHCY,GLTP,ACAD8,ALDH18A1,ALDH9A1,ABCC1,AACS,NSDHL,NQO2,NUDT4,AMD1,ACSL3,GBA,RPL6,PSMA1,VKORC1,PSMC4,RPL36,SDHB,GNAS,ORMDL2,PRPS2,COX7A2L,SLC16A1,NUP62,CTSA,ATP5F1A,PTDSS1,PDSS2,NDUFA5,MMACHC,UGP2,RPLP2,SUCLG1,NDUFAF2,MDH2,SLC2A1,UCK2,UCK1,CHKB,GGPS1,EXT2,RPL11,PDK2,NRF1,PSMA6,TNFAIP8,IARS,CS,CYB5R1,MINPP1,AHCYL1,GM2A,CHP1,ACSL5,RPL29,RPL35,PSMA8,PPT1,COQ10B,CPOX,PSMB7,MTMR6,GLO1,NUP155,OGDH,NDUFB1,RPS9,PDHX,RPSA,PON2,SCAP,PSMD3,NDUFA11,ARNTL,NCOA1,SCARB1,FAU,LTA4H,AP2S1,ABCA1,GCLM,NADSYN1,CDS2,RAE1,NUP54,SUMF1,CHAC2,ARF1,PIP4K2A,GSTK1,NDUFV1,GART,SEC24C,ABCD1,NDUFS8,PTGES3,SLC25A1,AMPD2,B3GALT6,CSNK1G2,ELOVL5,TIMMDC1,PRKAR1B,PNPLA8,ATP5MF,HAGH,NEU1,MTMR3,OSBPL8,COX8A,IMPDH1,ACAT1,ACADM,IDH3B,PGAM1,GCSH
R-HSA-1169091	Activation of NF-kappaB in B cells	0.141129391364641	-1.95807814015221	68	15	0.00884433962264151	1696	10287	5708,5707,5687,143471,6233,5714,5709,5695,5682,8454,5698,5715,5700,5691,5704	PSMD2,PSMD1,PSMA6,PSMA8,RPS27A,PSMD8,PSMD3,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,PSMC1,PSMB3,PSMC4
R-HSA-168928	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.141203301431037	-1.9575545729567	84	18	0.0106132075471698	1696	10287	23586,7323,55593,1540,7128,1660,80143,3661,351,8772,9636,6233,5300,10010,84166,57506,84282,5094	DDX58,UBE2D3,OTUD5,CYLD,TNFAIP3,DHX9,SIKE1,IRF3,APP,FADD,ISG15,RPS27A,PIN1,TANK,NLRC5,MAVS,RNF135,PCBP2
R-HSA-389513	CTLA4 inhibitory signaling	0.141225352160384	-1.95739842216171	22	6	0.0035377358490566	1696	10287	5170,5515,5525,4067,208,5781	PDPK1,PPP2CA,PPP2R5A,LYN,AKT2,PTPN11
R-HSA-438064	Post NMDA receptor activation events	0.143853603880066	-1.93895913625658	37	9	0.00530660377358491	1696	10287	5170,805,6195,5894,1385,5594,5566,3265,818	PDPK1,CALM2,RPS6KA1,RAF1,CREB1,MAPK1,PRKACA,HRAS,CAMK2G
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.144019965518204	-1.93780333958511	27	7	0.00412735849056604	1696	10287	3845,387,4893,4763,9844,3265,5879	KRAS,RHOA,NRAS,NF1,ELMO1,HRAS,RAC1
R-HSA-380994	ATF4 activates genes	0.144019965518204	-1.93780333958511	27	7	0.00412735849056604	1696	10287	8570,22926,5393,118460,23016,5073,51013	KHSRP,ATF6,EXOSC9,EXOSC6,EXOSC7,PARN,EXOSC1
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.144019965518204	-1.93780333958511	27	7	0.00412735849056604	1696	10287	7040,4087,57154,9110,6233,51377,11171	TGFB1,SMAD2,SMURF1,MTMR4,RPS27A,UCHL5,STRAP
R-HSA-70263	Gluconeogenesis	0.144617981838456	-1.93365962125971	32	8	0.00471698113207547	1696	10287	8604,4190,2821,5566,2806,5223,4191,6576	SLC25A12,MDH1,GPI,PRKACA,GOT2,PGAM1,MDH2,SLC25A1
R-HSA-74751	Insulin receptor signalling cascade	0.150072802378053	-1.89663475344268	297	56	0.0330188679245283	1696	10287	5564,7249,4763,5894,5562,8649,8315,64121,84335,5715,29904,805,2261,5708,5906,5707,5687,6464,5296,5781,818,64223,6709,5170,4893,143471,9978,208,8452,5695,5682,3845,5140,5698,5605,5691,6009,5595,5704,5515,7248,5525,3716,1445,6233,5714,5709,389541,84078,51719,6794,5536,409,5594,5700,3265	PRKAB1,TSC2,NF1,RAF1,PRKAA1,LAMTOR3,BRAP,RRAGC,AKT1S1,PSMD9,EEF2K,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,PDE3B,PSMB9,MAP2K2,PSMB3,RHEB,MAPK3,PSMC4,PPP2CA,TSC1,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,LAMTOR4,KBTBD7,CAB39,STK11,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	23586,57506,84282,8772	DDX58,MAVS,RNF135,FADD
R-HSA-350054	Notch-HLH transcription pathway	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	3516,4853,9794,2648	RBPJ,NOTCH2,MAML1,KAT2A
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	1540,7128,27005,8772	CYLD,TNFAIP3,USP21,FADD
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	3516,4853,1385,9794	RBPJ,NOTCH2,CREB1,MAML1
R-HSA-202670	ERKs are inactivated	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	5515,1845,5594,5595	PPP2CA,DUSP3,MAPK1,MAPK3
R-HSA-5626467	RHO GTPases activate IQGAPs	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	805,4221,998,5879	CALM2,MEN1,CDC42,RAC1
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.153366632000373	-1.87492393652423	13	4	0.00235849056603774	1696	10287	1027,890,1017,1869	CDKN1B,CCNA2,CDK2,E2F1
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.156129369088049	-1.8570703263768	48	11	0.00648584905660377	1696	10287	1540,7295,7128,330,23118,7335,596,598,1432,351,329	CYLD,TXN,TNFAIP3,BIRC3,TAB2,UBE2V1,BCL2,BCL2L1,MAPK14,APP,BIRC2
R-HSA-2428924	IGF1R signaling cascade	0.156440004981187	-1.85508269725395	298	56	0.0330188679245283	1696	10287	5564,7249,4763,5894,5562,8649,8315,64121,84335,5715,29904,805,2261,5708,5906,5707,5687,6464,5296,5781,818,64223,6709,5170,4893,143471,9978,208,8452,5695,5682,3845,5140,5698,5605,5691,6009,5595,5704,5515,7248,5525,3716,1445,6233,5714,5709,389541,84078,51719,6794,5536,409,5594,5700,3265	PRKAB1,TSC2,NF1,RAF1,PRKAA1,LAMTOR3,BRAP,RRAGC,AKT1S1,PSMD9,EEF2K,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,PDE3B,PSMB9,MAP2K2,PSMB3,RHEB,MAPK3,PSMC4,PPP2CA,TSC1,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,LAMTOR4,KBTBD7,CAB39,STK11,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-2428928	IRS-related events triggered by IGF1R	0.156440004981187	-1.85508269725395	298	56	0.0330188679245283	1696	10287	5564,7249,4763,5894,5562,8649,8315,64121,84335,5715,29904,805,2261,5708,5906,5707,5687,6464,5296,5781,818,64223,6709,5170,4893,143471,9978,208,8452,5695,5682,3845,5140,5698,5605,5691,6009,5595,5704,5515,7248,5525,3716,1445,6233,5714,5709,389541,84078,51719,6794,5536,409,5594,5700,3265	PRKAB1,TSC2,NF1,RAF1,PRKAA1,LAMTOR3,BRAP,RRAGC,AKT1S1,PSMD9,EEF2K,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,PDE3B,PSMB9,MAP2K2,PSMB3,RHEB,MAPK3,PSMC4,PPP2CA,TSC1,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,LAMTOR4,KBTBD7,CAB39,STK11,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	11116,6774,26127,399687,6772	FGFR1OP,STAT3,FGFR1OP2,MYO18A,STAT1
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	148022,3661,6233,10010,5781	TICAM1,IRF3,RPS27A,TANK,PTPN11
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	55802,5393,118460,23016,51013	DCP1A,EXOSC9,EXOSC6,EXOSC7,EXOSC1
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	3845,2261,4893,6464,3265	KRAS,FGFR3,NRAS,SHC1,HRAS
R-HSA-73780	RNA Polymerase III Chain Elongation	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	27297,84265,5441,5440,51728	CRCP,POLR3GL,POLR2L,POLR2K,POLR3K
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.162557256873329	-1.81672498928331	18	5	0.00294811320754717	1696	10287	55802,5393,118460,23016,51013	DCP1A,EXOSC9,EXOSC6,EXOSC7,EXOSC1
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.162966366204386	-1.81421144177126	299	56	0.0330188679245283	1696	10287	5564,7249,4763,5894,5562,8649,8315,64121,84335,5715,29904,805,2261,5708,5906,5707,5687,6464,5296,5781,818,64223,6709,5170,4893,143471,9978,208,8452,5695,5682,3845,5140,5698,5605,5691,6009,5595,5704,5515,7248,5525,3716,1445,6233,5714,5709,389541,84078,51719,6794,5536,409,5594,5700,3265	PRKAB1,TSC2,NF1,RAF1,PRKAA1,LAMTOR3,BRAP,RRAGC,AKT1S1,PSMD9,EEF2K,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,PDE3B,PSMB9,MAP2K2,PSMB3,RHEB,MAPK3,PSMC4,PPP2CA,TSC1,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,LAMTOR4,KBTBD7,CAB39,STK11,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-163316	Mitochondrial transcription termination	0.164868280353198	-1.8026084247831	1	1	0.000589622641509434	1696	10287	7978	MTERF1
R-HSA-1855231	Synthesis of IPs in the ER lumen	0.164868280353198	-1.8026084247831	1	1	0.000589622641509434	1696	10287	9562	MINPP1
R-HSA-3359474	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	0.164868280353198	-1.8026084247831	1	1	0.000589622641509434	1696	10287	25974	MMACHC
R-HSA-1483196	PI and PC transport between ER and Golgi membranes	0.164868280353198	-1.8026084247831	1	1	0.000589622641509434	1696	10287	23760	PITPNB
R-HSA-2033515	t(4;14) translocations of FGFR3	0.164868280353198	-1.8026084247831	1	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-1839126	FGFR2 mutant receptor activation	0.164942521672207	-1.80215821927251	33	8	0.00471698113207547	1696	10287	5438,5439,5436,5441,5440,5430,2962,5433	POLR2I,POLR2J,POLR2G,POLR2L,POLR2K,POLR2A,GTF2F1,POLR2D
R-HSA-3371571	HSF1-dependent transactivation	0.16595046628137	-1.79606593104987	23	6	0.0035377358490566	1696	10287	84335,3337,10728,818,3304,64223	AKT1S1,DNAJB1,PTGES3,CAMK2G,HSPA1B,MLST8
R-HSA-112409	RAF-independent MAPK1/3 activation	0.16595046628137	-1.79606593104987	23	6	0.0035377358490566	1696	10287	3716,5594,5605,3572,5595,5781	JAK1,MAPK1,MAP2K2,IL6ST,MAPK3,PTPN11
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.166308652774393	-1.79390986302202	28	7	0.00412735849056604	1696	10287	27297,84265,112495,2971,5441,5440,51728	CRCP,POLR3GL,GTF3C6,GTF3A,POLR2L,POLR2K,POLR3K
R-HSA-111933	Calmodulin induced events	0.166308652774393	-1.79390986302202	28	7	0.00412735849056604	1696	10287	805,1385,156,5566,115,5575,113	CALM2,CREB1,GRK2,PRKACA,ADCY9,PRKAR1B,ADCY7
R-HSA-111997	CaM pathway	0.166308652774393	-1.79390986302202	28	7	0.00412735849056604	1696	10287	805,1385,156,5566,115,5575,113	CALM2,CREB1,GRK2,PRKACA,ADCY9,PRKAR1B,ADCY7
R-HSA-202403	TCR signaling	0.166742049485031	-1.79130727457329	119	24	0.0141509433962264	1696	10287	5170,143471,4690,5695,5682,8454,7335,5698,5715,5691,5704,5708,5687,7454,5707,7408,5728,6233,23118,1445,5714,5709,5296,5700	PDPK1,PSMA8,NCK1,PSMB7,PSMA1,CUL1,UBE2V1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,WAS,PSMD1,VASP,PTEN,RPS27A,TAB2,CSK,PSMD8,PSMD3,PIK3R2,PSMC1
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.166987313347548	-1.78983743742985	108	22	0.0129716981132075	1696	10287	3015,5441,2648,5440,9219,23451,53615,94239,7270,221830,11335,1107,10849,9112,3014,9031,60,84172,3020,5928,30834,3066	H2AFZ,POLR2L,KAT2A,POLR2K,MTA2,SF3B1,MBD3,H2AFV,TTF1,TWISTNB,CBX3,CHD3,CD3EAP,MTA1,H2AFX,BAZ1B,ACTB,POLR1B,H3F3A,RBBP4,ZNRD1,HDAC2
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.173985006621118	-1.7487861523245	9	3	0.0017688679245283	1696	10287	4350,4968,8930	MPG,OGG1,MBD4
R-HSA-74182	Ketone body metabolism	0.173985006621118	-1.7487861523245	9	3	0.0017688679245283	1696	10287	38,65985,622	ACAT1,AACS,BDH1
R-HSA-2179392	EGFR Transactivation by Gastrin	0.173985006621118	-1.7487861523245	9	3	0.0017688679245283	1696	10287	3845,4893,3265	KRAS,NRAS,HRAS
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.173985006621118	-1.7487861523245	9	3	0.0017688679245283	1696	10287	1385,2309,208	CREB1,FOXO3,AKT2
R-HSA-163765	ChREBP activates metabolic gene expression	0.173985006621118	-1.7487861523245	9	3	0.0017688679245283	1696	10287	6945,47,10554	MLX,ACLY,AGPAT1
R-HSA-5668914	Diseases of metabolism	0.177824194134806	-1.72695989016079	44	10	0.00589622641509434	1696	10287	25974,2992,4594,6233,7270,4548,29080,7957,51293,56922	MMACHC,GYG1,MUT,RPS27A,TTF1,MTR,CCDC59,EPM2A,CD320,MCCC1
R-HSA-202424	Downstream TCR signaling	0.178743114803802	-1.72180561673001	98	20	0.0117924528301887	1696	10287	5170,143471,5695,5682,8454,7335,5698,5715,5691,5704,5708,5687,5707,5728,6233,23118,5709,5714,5296,5700	PDPK1,PSMA8,PSMB7,PSMA1,CUL1,UBE2V1,PSMB9,PSMD9,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,PTEN,RPS27A,TAB2,PSMD3,PSMD8,PIK3R2,PSMC1
R-HSA-400253	Circadian Clock	0.182785617468787	-1.69944130211222	71	15	0.00884433962264151	1696	10287	6233,406,4783,8454,1408,4209,8648,1385,26224,1386,5936,10499,10498,1453,1390	RPS27A,ARNTL,NFIL3,CUL1,CRY2,MEF2D,NCOA1,CREB1,FBXL3,ATF2,RBM4,NCOA2,CARM1,CSNK1D,CREM
R-HSA-157579	Telomere Maintenance	0.184504879459639	-1.69007936891556	82	17	0.0100235849056604	1696	10287	23649,5983,3015,5558,5982,94239,6117,5557,54386,6118,5111,5426,3014,10856,25913,7013,7014	POLA2,RFC3,H2AFZ,PRIM2,RFC2,H2AFV,RPA1,PRIM1,TERF2IP,RPA2,PCNA,POLE,H2AFX,RUVBL2,POT1,TERF1,TERF2
R-HSA-75109	Triglyceride Biosynthesis	0.184504879459639	-1.69007936891556	82	17	0.0100235849056604	1696	10287	51703,60481,10555,5538,9663,2181,1622,47,254531,10554,56894,9524,253558,23171,79888,80221,6576	ACSL5,ELOVL5,AGPAT2,PPT1,LPIN2,ACSL3,DBI,ACLY,LPCAT4,AGPAT1,AGPAT3,TECR,LCLAT1,GPD1L,LPCAT1,ACSF2,SLC25A1
R-HSA-73847	Purine metabolism	0.186492461917787	-1.6793644593865	34	8	0.00471698113207547	1696	10287	159,847,271,2618,1633,471,3614,158	ADSS,CAT,AMPD2,GART,DCK,ATIC,IMPDH1,ADSL
R-HSA-1489509	DAG and IP3 signaling	0.186492461917787	-1.6793644593865	34	8	0.00471698113207547	1696	10287	805,156,115,5575,10768,1385,5566,113	CALM2,GRK2,ADCY9,PRKAR1B,AHCYL1,CREB1,PRKACA,ADCY7
R-HSA-5694530	Cargo concentration in the ER	0.186492461917787	-1.6793644593865	34	8	0.00471698113207547	1696	10287	966,90411,3998,10972,9632,10959,10113,4253	CD59,MCFD2,LMAN1,TMED10,SEC24C,TMED2,PREB,MIA2
R-HSA-162594	Early Phase of HIV Life Cycle	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	3836,7518,8815,7520	KPNA1,XRCC4,BANF1,XRCC5
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-418885	DCC mediated attractive signaling	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	998,4690,5879,7204	CDC42,NCK1,RAC1,TRIO
R-HSA-1483213	Synthesis of PE	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	1120,5833,9663,1119	CHKB,PCYT2,LPIN2,CHKA
R-HSA-177504	Retrograde neurotrophin signalling	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	163,1175,10126,1785	AP2B1,AP2S1,DNAL4,DNM2
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-877312	Regulation of IFNG signaling	0.188240056062377	-1.67003723673914	14	4	0.00235849056603774	1696	10287	5771,3716,6772,5781	PTPN2,JAK1,STAT1,PTPN11
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.189016139494658	-1.66592287341674	372	68	0.0400943396226415	1696	10287	7249,4763,5894,5879,8454,4067,805,7409,5906,4193,5707,5687,6464,5296,1027,10768,64223,4893,143471,9978,208,8452,5695,4773,7335,5698,5515,5525,3716,6233,23118,5714,5709,5536,409,5594,5700,27161,7410,8649,8315,84335,5532,5715,5305,2309,23396,5708,2261,4775,5728,5781,1385,818,6709,5170,5530,79837,5682,3845,5605,5691,5595,5704,1445,84078,5534,3265	TSC2,NF1,RAF1,RAC1,CUL1,LYN,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,CDKN1B,AHCYL1,MLST8,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,NFATC2,UBE2V1,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,TAB2,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,AGO2,VAV2,LAMTOR3,BRAP,AKT1S1,PPP3CB,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,NFATC3,PTEN,PTPN11,CREB1,CAMK2G,SPTAN1,PDPK1,PPP3CA,PIP4K2C,PSMA1,KRAS,MAP2K2,PSMB3,MAPK3,PSMC4,CSK,KBTBD7,PPP3R1,HRAS
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.19000577633751	-1.66070080550741	29	7	0.00412735849056604	1696	10287	5170,805,7409,208,7410,5879,64223	PDPK1,CALM2,VAV1,AKT2,VAV2,RAC1,MLST8
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.19000577633751	-1.66070080550741	29	7	0.00412735849056604	1696	10287	5515,2261,8569,5594,6233,5595,5781	PPP2CA,FGFR3,MKNK1,MAPK1,RPS27A,MAPK3,PTPN11
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.190343093125745	-1.65892708194069	110	22	0.0129716981132075	1696	10287	3015,6195,79813,29882,8697,94239,5595,1031,890,8881,996,6233,3014,1027,51434,3020,1017,6774,11065,5594,29945,1029	H2AFZ,RPS6KA1,EHMT1,ANAPC2,CDC23,H2AFV,MAPK3,CDKN2C,CCNA2,CDC16,CDC27,RPS27A,H2AFX,CDKN1B,ANAPC7,H3F3A,CDK2,STAT3,UBE2C,MAPK1,ANAPC4,CDKN2A
R-HSA-416482	G alpha (12/13) signalling events	0.191637203944714	-1.65215125721812	88	18	0.0106132075471698	1696	10287	391,387,10276,389,2788,7410,5879,7204,23365,2783,388,7409,2768,998,9138,5296,9181,6093	RHOG,RHOA,NET1,RHOC,GNG7,VAV2,RAC1,TRIO,ARHGEF12,GNB2,RHOB,VAV1,GNA12,CDC42,ARHGEF1,PIK3R2,ARHGEF2,ROCK1
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.192341747320702	-1.64848155519762	24	6	0.0035377358490566	1696	10287	7323,7335,148022,330,6233,329	UBE2D3,UBE2V1,TICAM1,BIRC3,RPS27A,BIRC2
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	805,1385	CALM2,CREB1
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	2280,7040	FKBP1A,TGFB1
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	2280,7040	FKBP1A,TGFB1
R-HSA-75157	FasL/ CD95L signaling	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	8772,355	FADD,FAS
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	2280,7040	FKBP1A,TGFB1
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	34,3032	ACADM,HADHB
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	34,3032	ACADM,HADHB
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	3661,23220	IRF3,DTX4
R-HSA-8869496	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	4839,4605	NOP2,MYBL2
R-HSA-8853383	Lysosomal oligosaccharide catabolism	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	4125,4126	MAN2B1,MANBA
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	8454,9978	CUL1,RBX1
R-HSA-157881	Cyclin B2 mediated events	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	994,9133	CDC25B,CCNB2
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	8454,9978	CUL1,RBX1
R-HSA-8875513	MET interacts with TNS proteins	0.192751493431814	-1.64635351854374	5	2	0.00117924528301887	1696	10287	64759,3688	TNS3,ITGB1
R-HSA-2424491	DAP12 signaling	0.198049493214249	-1.6192383137953	356	65	0.0383254716981132	1696	10287	7249,4763,5894,5879,5566,805,7409,5906,4193,5707,5687,6464,5296,115,1027,10768,64223,113,4893,143471,9978,208,8452,5695,5698,5515,5525,3716,6233,5714,5709,5536,409,5594,5700,3133,27161,7410,8649,8315,84335,5715,5305,2309,23396,5708,2261,156,5728,5781,1385,818,6709,5170,79837,5575,5682,3845,5605,5691,5704,5595,1445,84078,3265	TSC2,NF1,RAF1,RAC1,PRKACA,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,ADCY9,CDKN1B,AHCYL1,MLST8,ADCY7,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,HLA-E,AGO2,VAV2,LAMTOR3,BRAP,AKT1S1,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,CAMK2G,SPTAN1,PDPK1,PIP4K2C,PRKAR1B,PSMA1,KRAS,MAP2K2,PSMB3,PSMC4,MAPK3,CSK,KBTBD7,HRAS
R-HSA-1227986	Signaling by ERBB2	0.209655188950942	-1.56229105513055	51	11	0.00648584905660377	1696	10287	387,26469,4893,6464,6233,208,51072,3845,55914,3265,11140	RHOA,PTPN18,NRAS,SHC1,RPS27A,AKT2,MEMO1,KRAS,ERBIN,HRAS,CDC37
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.213123754913691	-1.54588227300862	84	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.213123754913691	-1.54588227300862	84	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.213123754913691	-1.54588227300862	84	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-381042	PERK regulates gene expression	0.214965124727364	-1.53727947458243	30	7	0.00412735849056604	1696	10287	8570,22926,5393,118460,23016,5073,51013	KHSRP,ATF6,EXOSC9,EXOSC6,EXOSC7,PARN,EXOSC1
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.21930140805886	-1.51730820288187	330	60	0.035377358490566	1696	10287	10163,4763,5894,7410,5879,8649,8315,10787,5566,5715,1432,805,7409,2261,5708,5906,5707,5687,6464,998,5296,10768,10006,818,64223,6709,5170,23191,4893,387,143471,4690,7867,9978,208,8452,5695,5682,3845,26999,5698,5605,5691,5595,5704,5515,5525,3716,1445,9844,6233,5714,5709,84078,6093,5536,409,5594,5700,3265	WASF2,NF1,RAF1,VAV2,RAC1,LAMTOR3,BRAP,NCKAP1,PRKACA,PSMD9,MAPK14,CALM2,VAV1,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CDC42,PIK3R2,AHCYL1,ABI1,CAMK2G,MLST8,SPTAN1,PDPK1,CYFIP1,NRAS,RHOA,PSMA8,NCK1,MAPKAPK3,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,CYFIP2,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,CSK,ELMO1,RPS27A,PSMD8,PSMD3,KBTBD7,ROCK1,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-5663084	Diseases of carbohydrate metabolism	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	2992,6233,7957	GYG1,RPS27A,EPM2A
R-HSA-8868766	rRNA processing in the mitochondrion	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	55178,387338,29960	MRM3,NSUN4,MRM2
R-HSA-193692	Regulated proteolysis of p75NTR	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	6868,51107,83464	ADAM17,APH1A,APH1B
R-HSA-167590	Nef Mediated CD4 Down-regulation	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	163,375,1175	AP2B1,ARF1,AP2S1
R-HSA-3229121	Glycogen storage diseases	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	2992,6233,7957	GYG1,RPS27A,EPM2A
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	4998,23595,891	ORC1,ORC3,CCNB1
R-HSA-74749	Signal attenuation	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	6464,5594,5595	SHC1,MAPK1,MAPK3
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	2992,6233,7957	GYG1,RPS27A,EPM2A
R-HSA-727802	Transport of nucleotide sugars	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	347734,10559,84912	SLC35B2,SLC35A1,SLC35B4
R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	5300,5305,79837	PIN1,PIP4K2A,PIP4K2C
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	6118,5111,6117	RPA2,PCNA,RPA1
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	55190,11163,11165	NUDT11,NUDT4,NUDT3
R-HSA-201688	WNT mediated activation of DVL	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	1457,1855,1856	CSNK2A1,DVL1,DVL2
R-HSA-3215018	Processing and activation of SUMO	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	7329,29843,6613	UBE2I,SENP1,SUMO2
R-HSA-390450	Folding of actin by CCT/TriC	0.219701047539218	-1.51548753155916	10	3	0.0017688679245283	1696	10287	10576,60,10694	CCT2,ACTB,CCT8
R-HSA-182971	EGFR downregulation	0.22018863140991	-1.51327068450088	25	6	0.0035377358490566	1696	10287	29924,9146,998,6233,8027,5796	EPN1,HGS,CDC42,RPS27A,STAM,PTPRK
R-HSA-982772	Growth hormone receptor signaling	0.22018863140991	-1.51327068450088	25	6	0.0035377358490566	1696	10287	6868,5594,6774,4067,5595,6772	ADAM17,MAPK1,STAT3,LYN,MAPK3,STAT1
R-HSA-5654708	Downstream signaling of activated FGFR3	0.22018863140991	-1.51327068450088	25	6	0.0035377358490566	1696	10287	3845,2261,4893,6464,3265,5781	KRAS,FGFR3,NRAS,SHC1,HRAS,PTPN11
R-HSA-1483255	PI Metabolism	0.221193036939592	-1.50871948840269	79	16	0.00943396226415094	1696	10287	51552,79837,9107,23760,375,80230,5305,23396,55361,8897,25816,9110,5728,5867,5296,200576	RAB14,PIP4K2C,MTMR6,PITPNB,ARF1,RUFY1,PIP4K2A,PIP5K1C,PI4K2A,MTMR3,TNFAIP8,MTMR4,PTEN,RAB4A,PIK3R2,PIKFYVE
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.224144883650703	-1.4954626342013	20	5	0.00294811320754717	1696	10287	3845,2261,4893,3265,5781	KRAS,FGFR3,NRAS,HRAS,PTPN11
R-HSA-442755	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.224834461080784	-1.49239087608862	41	9	0.00530660377358491	1696	10287	5170,805,6195,5894,1385,5594,5566,3265,818	PDPK1,CALM2,RPS6KA1,RAF1,CREB1,MAPK1,PRKACA,HRAS,CAMK2G
R-HSA-156581	Methylation	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	27430,191,4548,4144	MAT2B,AHCY,MTR,MAT2A
R-HSA-3322077	Glycogen synthesis	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	2992,7360,6233,7957	GYG1,UGP2,RPS27A,EPM2A
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	55802,11157,219988,80153	DCP1A,LSM6,PATL1,EDC3
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	221496,891,9663,4000	LEMD2,CCNB1,LPIN2,LMNA
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	142678,6868,102,6233	MIB2,ADAM17,ADAM10,RPS27A
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	3661,22954,6233,23220	IRF3,TRIM32,RPS27A,DTX4
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	142678,6868,102,6233	MIB2,ADAM17,ADAM10,RPS27A
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.225314150791436	-1.49025962485482	15	4	0.00235849056603774	1696	10287	5515,5525,1452,8312	PPP2CA,PPP2R5A,CSNK1A1,AXIN1
R-HSA-111885	Opioid Signalling	0.228145070836961	-1.47777357676448	85	17	0.0100235849056604	1696	10287	5530,2788,5575,5532,5566,2783,5515,1020,805,156,115,5534,10768,1385,5594,2771,113	PPP3CA,GNG7,PRKAR1B,PPP3CB,PRKACA,GNB2,PPP2CA,CDK5,CALM2,GRK2,ADCY9,PPP3R1,AHCYL1,CREB1,MAPK1,GNAI2,ADCY7
R-HSA-1433557	Signaling by SCF-KIT	0.228310670012357	-1.4770479897345	337	61	0.0359669811320755	1696	10287	7249,4763,5894,27161,5879,8649,8315,84335,5715,4067,2309,5305,23396,805,7409,2261,5708,5906,4193,5707,5687,6464,5728,5296,5781,9306,1027,1385,6774,818,64223,6709,5170,4893,143471,9978,208,79837,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,1445,6233,5714,5709,84078,6772,5536,409,5594,5700,3265	TSC2,NF1,RAF1,AGO2,RAC1,LAMTOR3,BRAP,AKT1S1,PSMD9,LYN,FOXO3,PIP4K2A,PIP5K1C,CALM2,VAV1,FGFR3,PSMD2,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PTEN,PIK3R2,PTPN11,SOCS6,CDKN1B,CREB1,STAT3,CAMK2G,MLST8,SPTAN1,PDPK1,NRAS,PSMA8,RBX1,AKT2,PIP4K2C,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,KBTBD7,STAT1,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-168898	Toll-Like Receptors Cascades	0.232553947587318	-1.45863304823651	153	29	0.0170990566037736	1696	10287	7323,330,7867,6195,1660,8454,4205,7335,3661,2002,1432,351,329,8772,5595,5515,1514,1520,1845,6233,23118,10010,5781,1785,148022,1385,1386,5594,10695	UBE2D3,BIRC3,MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,IRF3,ELK1,MAPK14,APP,BIRC2,FADD,MAPK3,PPP2CA,CTSL,CTSS,DUSP3,RPS27A,TAB2,TANK,PTPN11,DNM2,TICAM1,CREB1,ATF2,MAPK1,CNPY3
R-HSA-167021	PLC-gamma1 signalling	0.232832688083593	-1.45743516025159	36	8	0.00471698113207547	1696	10287	805,156,115,5575,10768,1385,5566,113	CALM2,GRK2,ADCY9,PRKAR1B,AHCYL1,CREB1,PRKACA,ADCY7
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.232832688083593	-1.45743516025159	36	8	0.00471698113207547	1696	10287	112495,5441,5440,84265,27297,2971,51728,6621	GTF3C6,POLR2L,POLR2K,POLR3GL,CRCP,GTF3A,POLR3K,SNAPC4
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.232832688083593	-1.45743516025159	36	8	0.00471698113207547	1696	10287	805,156,115,5575,10768,1385,5566,113	CALM2,GRK2,ADCY9,PRKAR1B,AHCYL1,CREB1,PRKACA,ADCY7
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.234494188837356	-1.45032447248023	91	18	0.0106132075471698	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,148022,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,TICAM1,CREB1,MAPK1,ATF2
R-HSA-112043	PLC beta mediated events	0.237935960327619	-1.43575371577134	47	10	0.00589622641509434	1696	10287	805,156,115,5575,1385,10768,5594,5566,2771,113	CALM2,GRK2,ADCY9,PRKAR1B,CREB1,AHCYL1,MAPK1,PRKACA,GNAI2,ADCY7
R-HSA-373752	Netrin-1 signaling	0.247367005378759	-1.39688219340374	42	9	0.00530660377358491	1696	10287	7430,5306,998,4690,6477,5879,7204,6478,5781	EZR,PITPNA,CDC42,NCK1,SIAH1,RAC1,TRIO,SIAH2,PTPN11
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.24907971786199	-1.38998228169898	53	11	0.00648584905660377	1696	10287	11336,10576,4218,60412,5311,6102,117177,8766,10694,378,166379	EXOC3,CCT2,RAB8A,EXOC4,PKD2,RP2,RAB3IP,RAB11A,CCT8,ARF4,BBS12
R-HSA-73848	Pyrimidine metabolism	0.249264772807468	-1.38923960285955	26	6	0.0035377358490566	1696	10287	83549,1635,7083,1633,1854,7371	UCK1,DCTD,TK1,DCK,DUT,UCK2
R-HSA-2559580	Oxidative Stress Induced Senescence	0.250313928618742	-1.38503943439495	126	24	0.0141509433962264	1696	10287	3015,7295,7867,23512,9448,1871,1432,94239,5595,1912,1031,4193,6233,7027,3014,1869,4217,7029,5928,3020,1870,5594,8535,1029	H2AFZ,TXN,MAPKAPK3,SUZ12,MAP4K4,E2F3,MAPK14,H2AFV,MAPK3,PHC2,CDKN2C,MDM2,RPS27A,TFDP1,H2AFX,E2F1,MAP3K5,TFDP2,RBBP4,H3F3A,E2F2,MAPK1,CBX4,CDKN2A
R-HSA-5693607	Processing of DNA double-strand break ends	0.255127846659632	-1.36599050001283	98	19	0.0112028301886792	1696	10287	5983,63967,6613,29086,116028,7156,672,7329,641,5982,80010,6117,6118,890,9577,6233,3014,8914,1017	RFC3,CLSPN,SUMO2,BABAM1,RMI2,TOP3A,BRCA1,UBE2I,BLM,RFC2,RMI1,RPA1,RPA2,CCNA2,BABAM2,RPS27A,H2AFX,TIMELESS,CDK2
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.257204494133093	-1.35788381347004	21	5	0.00294811320754717	1696	10287	25974,4594,4548,51293,4363	MMACHC,MUT,MTR,CD320,ABCC1
R-HSA-186797	Signaling by PDGF	0.258766783514327	-1.35182807268264	376	67	0.0395047169811321	1696	10287	7249,4763,5894,5566,1399,805,7409,5906,4193,5707,5687,6464,5296,115,1027,10768,64223,113,4893,143471,9978,4690,208,8452,5695,5698,5515,5525,3716,6233,5714,6778,5709,6772,5536,409,5594,5700,27161,8649,8315,84335,5715,5305,2309,23396,5708,2261,156,5728,5781,1385,6774,818,6709,5170,79837,5575,5682,3845,5605,5691,5595,5704,1445,84078,3265	TSC2,NF1,RAF1,PRKACA,CRKL,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,ADCY9,CDKN1B,AHCYL1,MLST8,ADCY7,NRAS,PSMA8,RBX1,NCK1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,STAT6,PSMD3,STAT1,PPP5C,ARRB2,MAPK1,PSMC1,AGO2,LAMTOR3,BRAP,AKT1S1,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,STAT3,CAMK2G,SPTAN1,PDPK1,PIP4K2C,PRKAR1B,PSMA1,KRAS,MAP2K2,PSMB3,MAPK3,PSMC4,CSK,KBTBD7,HRAS
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	11108,3066	PRDM4,HDAC2
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	55253,129450	TYW1,TYW5
R-HSA-500753	Pyrimidine biosynthesis	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	1635,1854	DCTD,DUT
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	4998,23595	ORC1,ORC3
R-HSA-8849470	PTK6 Regulates Cell Cycle	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	1027,1017	CDKN1B,CDK2
R-HSA-3065679	SUMO is proteolytically processed	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	29843,6613	SENP1,SUMO2
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	805,1385	CALM2,CREB1
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.258872280874915	-1.35142046294332	6	2	0.00117924528301887	1696	10287	7040,4087	TGFB1,SMAD2
R-HSA-112040	G-protein mediated events	0.259464010654929	-1.3491372732584	48	10	0.00589622641509434	1696	10287	805,156,115,5575,1385,10768,5594,5566,2771,113	CALM2,GRK2,ADCY9,PRKAR1B,CREB1,AHCYL1,MAPK1,PRKACA,GNAI2,ADCY7
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.259464010654929	-1.3491372732584	48	10	0.00589622641509434	1696	10287	892,9612,2648,9978,6233,51564,8454,3516,9794,3066	CCNC,NCOR2,KAT2A,RBX1,RPS27A,HDAC7,CUL1,RBPJ,MAML1,HDAC2
R-HSA-399956	CRMPs in Sema3A signaling	0.26402323041216	-1.33171818572161	16	4	0.00235849056603774	1696	10287	1020,5361,1808,1809	CDK5,PLXNA1,DPYSL2,DPYSL3
R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	0.26402323041216	-1.33171818572161	16	4	0.00235849056603774	1696	10287	93183,23556,9091,54872	PIGM,PIGN,PIGQ,PIGG
R-HSA-392517	Rap1 signalling	0.26402323041216	-1.33171818572161	16	4	0.00235849056603774	1696	10287	7534,5906,5566,5894	YWHAZ,RAP1A,PRKACA,RAF1
R-HSA-163615	PKA activation	0.26402323041216	-1.33171818572161	16	4	0.00235849056603774	1696	10287	5566,115,5575,113	PRKACA,ADCY9,PRKAR1B,ADCY7
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.26402323041216	-1.33171818572161	16	4	0.00235849056603774	1696	10287	5361,3984,1072,5879	PLXNA1,LIMK1,CFL1,RAC1
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.265118987455987	-1.32757654450254	93	18	0.0106132075471698	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,148022,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,TICAM1,CREB1,MAPK1,ATF2
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.265118987455987	-1.32757654450254	93	18	0.0106132075471698	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,148022,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,TICAM1,CREB1,MAPK1,ATF2
R-HSA-2172127	DAP12 interactions	0.26543165405001	-1.32639789497972	371	66	0.0389150943396226	1696	10287	7249,4763,5894,5879,5566,805,7409,5906,4193,5707,5687,6464,5296,115,1027,10768,64223,113,4893,143471,9978,208,8452,5695,5698,5515,5525,3716,6233,5714,5709,5536,409,5594,5700,3133,27161,7410,8649,8315,84335,5715,5305,2309,23396,5708,2261,156,5728,5781,1385,818,6709,5170,79837,5575,5682,3845,5605,5691,5704,5595,3106,1445,84078,3265	TSC2,NF1,RAF1,RAC1,PRKACA,CALM2,VAV1,RAP1A,MDM2,PSMD1,PSMA6,SHC1,PIK3R2,ADCY9,CDKN1B,AHCYL1,MLST8,ADCY7,NRAS,PSMA8,RBX1,AKT2,CUL3,PSMB7,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,PPP5C,ARRB2,MAPK1,PSMC1,HLA-E,AGO2,VAV2,LAMTOR3,BRAP,AKT1S1,PSMD9,PIP4K2A,FOXO3,PIP5K1C,PSMD2,FGFR3,GRK2,PTEN,PTPN11,CREB1,CAMK2G,SPTAN1,PDPK1,PIP4K2C,PRKAR1B,PSMA1,KRAS,MAP2K2,PSMB3,PSMC4,MAPK3,HLA-B,CSK,KBTBD7,HRAS
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	891,10844,114791	CCNB1,TUBGCP2,TUBGCP5
R-HSA-3371378	Regulation by c-FLIP	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	8772,8837,355	FADD,CFLAR,FAS
R-HSA-1980148	Signaling by NOTCH3	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	102,51107,83464	ADAM10,APH1A,APH1B
R-HSA-5218900	CASP8 activity is inhibited	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	8772,8837,355	FADD,CFLAR,FAS
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	6118,5111,6117	RPA2,PCNA,RPA1
R-HSA-5655291	Signaling by FGFR4 in disease	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	3845,4893,3265	KRAS,NRAS,HRAS
R-HSA-69416	Dimerization of procaspase-8	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	8772,8837,355	FADD,CFLAR,FAS
R-HSA-189451	Heme biosynthesis	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	1355,1371,7389	COX15,CPOX,UROD
R-HSA-8875555	MET activates RAP1 and RAC1	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	1399,5906,5879	CRKL,RAP1A,RAC1
R-HSA-1980150	Signaling by NOTCH4	0.267432206347085	-1.31888917898246	11	3	0.0017688679245283	1696	10287	102,51107,83464	ADAM10,APH1A,APH1B
R-HSA-168638	NOD1/2 Signaling Pathway	0.268021271336286	-1.31668893096318	32	7	0.00412735849056604	1696	10287	7335,1540,7128,330,23118,1432,329	UBE2V1,CYLD,TNFAIP3,BIRC3,TAB2,MAPK14,BIRC2
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.268021271336286	-1.31668893096318	32	7	0.00412735849056604	1696	10287	2768,409,5594,2149,2783,2788,5595	GNA12,ARRB2,MAPK1,F2R,GNB2,GNG7,MAPK3
R-HSA-1236394	Signaling by ERBB4	0.270617967374236	-1.30704716717094	43	9	0.00530660377358491	1696	10287	6868,4893,6464,51107,23118,6233,3845,83464,3265	ADAM17,NRAS,SHC1,APH1A,TAB2,RPS27A,KRAS,APH1B,HRAS
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.279334717747804	-1.27534451104272	27	6	0.0035377358490566	1696	10287	27297,84265,112495,5441,5440,51728	CRCP,POLR3GL,GTF3C6,POLR2L,POLR2K,POLR3K
R-HSA-5655302	Signaling by FGFR1 in disease	0.282666483111718	-1.26348758122748	38	8	0.00471698113207547	1696	10287	11116,4893,399687,6772,3845,6774,3265,26127	FGFR1OP,NRAS,MYO18A,STAT1,KRAS,STAT3,HRAS,FGFR1OP2
R-HSA-194138	Signaling by VEGF	0.283268561602193	-1.26135985041015	338	60	0.035377358490566	1696	10287	10163,4763,5894,7410,5879,8649,8315,10787,5566,5715,1432,805,7409,2261,5708,5906,5707,5687,6464,998,5296,10768,10006,818,64223,6709,5170,23191,4893,387,143471,4690,7867,9978,208,8452,5695,5682,3845,26999,5698,5605,5691,5595,5704,5515,5525,3716,1445,9844,6233,5714,5709,84078,6093,5536,409,5594,5700,3265	WASF2,NF1,RAF1,VAV2,RAC1,LAMTOR3,BRAP,NCKAP1,PRKACA,PSMD9,MAPK14,CALM2,VAV1,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CDC42,PIK3R2,AHCYL1,ABI1,CAMK2G,MLST8,SPTAN1,PDPK1,CYFIP1,NRAS,RHOA,PSMA8,NCK1,MAPKAPK3,RBX1,AKT2,CUL3,PSMB7,PSMA1,KRAS,CYFIP2,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,CSK,ELMO1,RPS27A,PSMD8,PSMD3,KBTBD7,ROCK1,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.291316006471195	-1.23334666811855	22	5	0.00294811320754717	1696	10287	5170,9020,208,5296,64223	PDPK1,MAP3K14,AKT2,PIK3R2,MLST8
R-HSA-163359	Glucagon signaling in metabolic regulation	0.295773242406119	-1.21816219119421	33	7	0.00412735849056604	1696	10287	2778,5566,2783,2788,115,5575,113	GNAS,PRKACA,GNB2,GNG7,ADCY9,PRKAR1B,ADCY7
R-HSA-168277	Influenza Virus Induced Apoptosis	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	7040	TGFB1
R-HSA-1483101	Synthesis of PS	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	9791	PTDSS1
R-HSA-5652227	Fructose biosynthesis	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	231	AKR1B1
R-HSA-3359469	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	4548	MTR
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	2992	GYG1
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	7040	TGFB1
R-HSA-111457	Release of apoptotic factors from the mitochondria	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	54205	CYCS
R-HSA-3359467	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	4548	MTR
R-HSA-3359478	Defective MUT causes methylmalonic aciduria mut type	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	4594	MUT
R-HSA-5357609	Glycogen storage disease type II (GAA)	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	2992	GYG1
R-HSA-3359475	Defective MMAA causes methylmalonic aciduria type cblA	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	4594	MUT
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	2992	GYG1
R-HSA-168315	Inhibition of Host mRNA Processing and RNA Silencing	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	10898	CPSF4
R-HSA-5602566	TICAM1 deficiency - HSE	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	148022	TICAM1
R-HSA-3359485	Defective CD320 causes methylmalonic aciduria	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	51293	CD320
R-HSA-3359473	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	25974	MMACHC
R-HSA-111995	phospho-PLA2 pathway	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	5594	MAPK1
R-HSA-111452	Activation and oligomerization of BAK protein	0.302568396675742	-1.19544792235586	2	1	0.000589622641509434	1696	10287	578	BAK1
R-HSA-622312	Inflammasomes	0.303816847293599	-1.19133023514541	17	4	0.00235849056603774	1696	10287	596,598,7295,351	BCL2,BCL2L1,TXN,APP
R-HSA-140534	Ligand-dependent caspase activation	0.303816847293599	-1.19133023514541	17	4	0.00235849056603774	1696	10287	148022,8772,8837,355	TICAM1,FADD,CFLAR,FAS
R-HSA-2142845	Hyaluronan metabolism	0.303816847293599	-1.19133023514541	17	4	0.00235849056603774	1696	10287	3073,3074,10057,11261	HEXA,HEXB,ABCC5,CHP1
R-HSA-5654736	Signaling by FGFR1	0.304245166535072	-1.18992143373183	50	10	0.00589622641509434	1696	10287	5515,8569,4893,6464,6233,5781,3845,5594,3265,5595	PPP2CA,MKNK1,NRAS,SHC1,RPS27A,PTPN11,KRAS,MAPK1,HRAS,MAPK3
R-HSA-427413	NoRC negatively regulates rRNA expression	0.305551398537288	-1.18563727053734	107	20	0.0117924528301887	1696	10287	3015,5441,11176,5440,94239,7270,221830,79595,7343,10849,8932,3014,84172,3020,30834,2966,1786,79685,3066,8819	H2AFZ,POLR2L,BAZ2A,POLR2K,H2AFV,TTF1,TWISTNB,SAP130,UBTF,CD3EAP,MBD2,H2AFX,POLR1B,H3F3A,ZNRD1,GTF2H2,DNMT1,SAP30L,HDAC2,SAP30
R-HSA-76002	Platelet activation, signaling and aggregation	0.307729687150927	-1.17853352047962	282	50	0.0294811320754717	1696	10287	391,5894,5552,7410,5879,22927,29789,54495,1432,4067,2783,351,83706,78991,805,7409,334,5906,6464,27154,998,5296,5781,308,8407,51706,139322,2771,2149,1072,5170,7040,387,51571,208,9948,2788,388,5595,10916,2768,3716,1445,10447,7534,5660,1191,409,5594,66005	RHOG,RAF1,SRGN,VAV2,RAC1,HABP4,OLA1,TMX3,MAPK14,LYN,GNB2,APP,FERMT3,PCYOX1L,CALM2,VAV1,APLP2,RAP1A,SHC1,BRPF3,CDC42,PIK3R2,PTPN11,ANXA5,TAGLN2,CYB5R1,APOOL,GNAI2,F2R,CFL1,PDPK1,TGFB1,RHOA,FAM49B,AKT2,WDR1,GNG7,RHOB,MAPK3,MAGED2,GNA12,JAK1,CSK,FAM3C,YWHAZ,PSAP,CLU,ARRB2,MAPK1,CHID1
R-HSA-6783310	Fanconi Anemia Pathway	0.308559142284913	-1.17584174482121	39	8	0.00471698113207547	1696	10287	55120,6118,2067,2178,6233,80233,55215,6117	FANCL,RPA2,ERCC1,FANCE,RPS27A,FAAP100,FANCI,RPA1
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	0.308559142284913	-1.17584174482121	39	8	0.00471698113207547	1696	10287	1984,1725,79672,120526,25870,285362,23463,153642	EIF5A,DHPS,FN3KRP,DNAJC24,SUMF2,SUMF1,ICMT,ARSK
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	0.308559142284913	-1.17584174482121	39	8	0.00471698113207547	1696	10287	805,7409,80228,6464,4690,84876,10768,4067	CALM2,VAV1,ORAI2,SHC1,NCK1,ORAI1,AHCYL1,LYN
R-HSA-2022854	Keratan sulfate biosynthesis	0.310160008193542	-1.17066695920232	28	6	0.0035377358490566	1696	10287	2683,6483,8702,8703,9334,8704	B4GALT1,ST3GAL2,B4GALT4,B4GALT3,B4GALT5,B4GALT2
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.310160008193542	-1.17066695920232	28	6	0.0035377358490566	1696	10287	27297,84265,5441,5440,6621,51728	CRCP,POLR3GL,POLR2L,POLR2K,SNAPC4,POLR3K
R-HSA-3214841	PKMTs methylate histone lysines	0.311831738776203	-1.16529153544078	73	14	0.00825471698113208	1696	10287	55870,79723,84787,55904,387893,23512,84193,79813,9757,54904,11091,58508,5928,84444	ASH1L,SUV39H2,KMT5C,KMT2E,KMT5A,SUZ12,SETD3,EHMT1,KMT2B,NSD3,WDR5,KMT2C,RBBP4,DOT1L
R-HSA-2160916	Hyaluronan uptake and degradation	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	3073,3074,11261	HEXA,HEXB,CHP1
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	124446,7159,355	TMEM219,TP53BP2,FAS
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	7534,891,7533	YWHAZ,CCNB1,YWHAH
R-HSA-3371511	HSF1 activation	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	6118,10728,6117	RPA2,PTGES3,RPA1
R-HSA-2022857	Keratan sulfate degradation	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	2799,3073,3074	GNS,HEXA,HEXB
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	9126,113130,23047	SMC3,CDCA5,PDS5B
R-HSA-389359	CD28 dependent Vav1 pathway	0.316158925525558	-1.15151026294322	12	3	0.0017688679245283	1696	10287	7409,998,5879	VAV1,CDC42,RAC1
R-HSA-195721	Signaling by Wnt	0.316973978348126	-1.14893559570408	336	59	0.0347877358490566	1696	10287	3015,27161,5879,331,8454,1457,6597,5532,84133,1452,5715,2783,79577,8323,805,5708,5707,5687,8313,163,1212,1856,9736,1455,5530,387,143471,9978,208,2788,8452,5695,5682,23401,4041,6659,4221,94239,5698,5691,5704,80319,5515,5525,6233,5714,81029,8312,5709,5534,3014,7534,1855,3020,409,57154,5700,1175,51699	H2AFZ,AGO2,RAC1,XIAP,CUL1,CSNK2A1,SMARCA4,PPP3CB,ZNRF3,CSNK1A1,PSMD9,GNB2,CDC73,FZD6,CALM2,PSMD2,PSMD1,PSMA6,AXIN2,AP2B1,CLTB,DVL2,USP34,CSNK1G2,PPP3CA,RHOA,PSMA8,RBX1,AKT2,GNG7,CUL3,PSMB7,PSMA1,FRAT2,LRP5,SOX4,MEN1,H2AFV,PSMB9,PSMB3,PSMC4,CXXC4,PPP2CA,PPP2R5A,RPS27A,PSMD8,WNT5B,AXIN1,PSMD3,PPP3R1,H2AFX,YWHAZ,DVL1,H3F3A,ARRB2,SMURF1,PSMC1,AP2S1,VPS29
R-HSA-3214858	RMTs methylate histone arginines	0.317215314836975	-1.14817450905979	79	15	0.00884433962264151	1696	10287	6187,1788,3015,196528,3014,6597,54496,8289,55193,11091,94239,6605,57492,10498,6602	RPS2,DNMT3A,H2AFZ,ARID2,H2AFX,SMARCA4,PRMT7,ARID1A,PBRM1,WDR5,H2AFV,SMARCE1,ARID1B,CARM1,SMARCD1
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.318778468489865	-1.14325887358828	131	24	0.0141509433962264	1696	10287	5170,7249,208,27161,79837,84335,4067,2309,5305,5595,23396,7409,5515,2261,4193,5525,6464,5728,5296,5781,1027,1385,5594,64223	PDPK1,TSC2,AKT2,AGO2,PIP4K2C,AKT1S1,LYN,FOXO3,PIP4K2A,MAPK3,PIP5K1C,VAV1,PPP2CA,FGFR3,MDM2,PPP2R5A,SHC1,PTEN,PIK3R2,PTPN11,CDKN1B,CREB1,MAPK1,MLST8
R-HSA-8852135	Protein ubiquitination	0.319523454380102	-1.14092459821852	62	12	0.00707547169811321	1696	10287	7323,54623,7874,92912,6233,5591,65264,9646,23168,11065,79577,8078	UBE2D3,PAF1,USP7,UBE2Q2,RPS27A,PRKDC,UBE2Z,CTR9,RTF1,UBE2C,CDC73,USP5
R-HSA-194840	Rho GTPase cycle	0.324069817533259	-1.12679630018986	143	26	0.0153301886792453	1696	10287	391,55114,387,9322,10276,389,23526,7410,5879,7204,29127,397,23365,4650,55288,89941,388,55843,7409,998,5296,9138,116985,9181,4649,57636	RHOG,ARHGAP17,RHOA,TRIP10,NET1,RHOC,ARHGAP45,VAV2,RAC1,TRIO,RACGAP1,ARHGDIB,ARHGEF12,MYO9B,RHOT1,RHOT2,RHOB,ARHGAP15,VAV1,CDC42,PIK3R2,ARHGEF1,ARAP1,ARHGEF2,MYO9A,ARHGAP23
R-HSA-1483166	Synthesis of PA	0.324105296597038	-1.12668682649043	34	7	0.00412735849056604	1696	10287	56894,10555,79888,23171,253558,254531,10554	AGPAT3,AGPAT2,LPCAT1,GPD1L,LCLAT1,LPCAT4,AGPAT1
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	1385,5566	CREB1,PRKACA
R-HSA-182218	Nef Mediated CD8 Down-regulation	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	163,1175	AP2B1,AP2S1
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	221496,8815	LEMD2,BANF1
R-HSA-199920	CREB phosphorylation	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	1385,6195	CREB1,RPS6KA1
R-HSA-111471	Apoptotic factor-mediated response	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	54205,331	CYCS,XIAP
R-HSA-75158	TRAIL  signaling	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	8772,8837	FADD,CFLAR
R-HSA-174362	Transport and synthesis of PAPS	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	1836,347734	SLC26A2,SLC35B2
R-HSA-426117	Cation-coupled Chloride cotransporters	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	10723,6558	SLC12A7,SLC12A2
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	6868,102	ADAM17,ADAM10
R-HSA-3065678	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	7329,6613	UBE2I,SUMO2
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	4968,252969	OGG1,NEIL2
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	6868,102	ADAM17,ADAM10
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.325143562092596	-1.12348846467048	7	2	0.00117924528301887	1696	10287	4853,23509	NOTCH2,POFUT1
R-HSA-73980	RNA Polymerase III Transcription Termination	0.326139767640202	-1.12042925440341	23	5	0.00294811320754717	1696	10287	27297,84265,5441,5440,51728	CRCP,POLR3GL,POLR2L,POLR2K,POLR3K
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.326139767640202	-1.12042925440341	23	5	0.00294811320754717	1696	10287	7323,9612,4087,6233,4089	UBE2D3,NCOR2,SMAD2,RPS27A,SMAD4
R-HSA-379726	Mitochondrial tRNA aminoacylation	0.326139767640202	-1.12042925440341	23	5	0.00294811320754717	1696	10287	3735,5859,27068,55699,79587	KARS,QARS,PPA2,IARS2,CARS2
R-HSA-15869	Metabolism of nucleotides	0.330250988357278	-1.10790234282936	97	18	0.0106132075471698	1696	10287	271,7083,7295,2987,7371,6240,83549,6241,158,1635,847,159,2618,1633,1854,471,1503,3614	AMPD2,TK1,TXN,GUK1,UCK2,RRM1,UCK1,RRM2,ADSL,DCTD,CAT,ADSS,GART,DCK,DUT,ATIC,CTPS1,IMPDH1
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.330250988357278	-1.10790234282936	97	18	0.0106132075471698	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,148022,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,TICAM1,CREB1,MAPK1,ATF2
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.334917960289599	-1.09386967180658	40	8	0.00471698113207547	1696	10287	10576,2629,26190,26224,8237,6774,10694,83752	CCT2,GBA,FBXW2,FBXL3,USP11,STAT3,CCT8,LONP2
R-HSA-201681	TCF dependent signaling in response to WNT	0.338937239104453	-1.08194032412645	238	42	0.0247641509433962	1696	10287	3015,331,1457,6597,84133,1452,5715,79577,8323,5708,5707,5687,8313,1856,9736,1455,9978,143471,208,8452,5695,5682,23401,4041,6659,4221,94239,5698,5691,5704,80319,5515,5525,6233,5714,5709,8312,3014,7534,1855,3020,5700	H2AFZ,XIAP,CSNK2A1,SMARCA4,ZNRF3,CSNK1A1,PSMD9,CDC73,FZD6,PSMD2,PSMD1,PSMA6,AXIN2,DVL2,USP34,CSNK1G2,RBX1,PSMA8,AKT2,CUL3,PSMB7,PSMA1,FRAT2,LRP5,SOX4,MEN1,H2AFV,PSMB9,PSMB3,PSMC4,CXXC4,PPP2CA,PPP2R5A,RPS27A,PSMD8,PSMD3,AXIN1,H2AFX,YWHAZ,DVL1,H3F3A,PSMC1
R-HSA-375170	CDO in myogenesis	0.341504590410072	-1.07439415815805	29	6	0.0035377358490566	1696	10287	6938,4205,4209,998,1432,6929	TCF12,MEF2A,MEF2D,CDC42,MAPK14,TCF3
R-HSA-390918	Peroxisomal lipid metabolism	0.341504590410072	-1.07439415815805	29	6	0.0035377358490566	1696	10287	23417,79777,390916,215,1384,51	MLYCD,ACBD4,NUDT19,ABCD1,CRAT,ACOX1
R-HSA-525793	Myogenesis	0.341504590410072	-1.07439415815805	29	6	0.0035377358490566	1696	10287	6938,4205,4209,998,1432,6929	TCF12,MEF2A,MEF2D,CDC42,MAPK14,TCF3
R-HSA-912631	Regulation of signaling by CBL	0.34417673026843	-1.06660000275317	18	4	0.00235849056603774	1696	10287	1399,7409,4067,5296	CRKL,VAV1,LYN,PIK3R2
R-HSA-5635838	Activation of SMO	0.34417673026843	-1.06660000275317	18	4	0.00235849056603774	1696	10287	156,409,1452,132884	GRK2,ARRB2,CSNK1A1,EVC2
R-HSA-388841	Costimulation by the CD28 family	0.345795916930954	-1.06190651340545	69	13	0.00766509433962264	1696	10287	5170,5515,7409,5525,998,1445,208,5296,5879,5781,9020,4067,64223	PDPK1,PPP2CA,VAV1,PPP2R5A,CDC42,CSK,AKT2,PIK3R2,RAC1,PTPN11,MAP3K14,LYN,MLST8
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.350255971481294	-1.04909104471323	104	19	0.0112028301886792	1696	10287	330,143471,5695,5682,8454,5698,5715,329,5691,5704,5708,5687,5707,6233,5709,5714,9020,9040,5700	BIRC3,PSMA8,PSMB7,PSMA1,CUL1,PSMB9,PSMD9,BIRC2,PSMB3,PSMC4,PSMD2,PSMA6,PSMD1,RPS27A,PSMD3,PSMD8,MAP3K14,UBE2M,PSMC1
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.353083778222163	-1.04104991813353	110	20	0.0117924528301887	1696	10287	3015,5441,11176,5440,94239,7270,221830,79595,7343,10849,8932,3014,84172,3020,30834,2966,1786,79685,3066,8819	H2AFZ,POLR2L,BAZ2A,POLR2K,H2AFV,TTF1,TWISTNB,SAP130,UBTF,CD3EAP,MBD2,H2AFX,POLR1B,H3F3A,ZNRD1,GTF2H2,DNMT1,SAP30L,HDAC2,SAP30
R-HSA-180292	GAB1 signalosome	0.360241471451226	-1.02098071835574	128	23	0.013561320754717	1696	10287	5170,7249,208,27161,79837,84335,2309,5305,5595,23396,7409,5515,2261,4193,5525,5728,1445,5296,5781,1027,1385,5594,64223	PDPK1,TSC2,AKT2,AGO2,PIP4K2C,AKT1S1,FOXO3,PIP4K2A,MAPK3,PIP5K1C,VAV1,PPP2CA,FGFR3,MDM2,PPP2R5A,PTEN,CSK,PIK3R2,PTPN11,CDKN1B,CREB1,MAPK1,MLST8
R-HSA-198203	PI3K/AKT activation	0.360241471451226	-1.02098071835574	128	23	0.013561320754717	1696	10287	5170,387,7249,208,27161,79837,84335,2309,5305,5595,23396,7409,5515,2261,4193,5525,5728,5296,5781,1027,1385,5594,64223	PDPK1,RHOA,TSC2,AKT2,AGO2,PIP4K2C,AKT1S1,FOXO3,PIP4K2A,MAPK3,PIP5K1C,VAV1,PPP2CA,FGFR3,MDM2,PPP2R5A,PTEN,PIK3R2,PTPN11,CDKN1B,CREB1,MAPK1,MLST8
R-HSA-70895	Branched-chain amino acid catabolism	0.361349772985513	-1.01790888949324	24	5	0.00294811320754717	1696	10287	38,27034,223,56922,587	ACAT1,ACAD8,ALDH9A1,MCCC1,BCAT2
R-HSA-191273	Cholesterol biosynthesis	0.361349772985513	-1.01790888949324	24	5	0.00294811320754717	1696	10287	10654,9453,50814,10682,2222	PMVK,GGPS1,NSDHL,EBP,FDFT1
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.361604869180086	-1.01720318490188	41	8	0.00471698113207547	1696	10287	112495,5441,5440,84265,27297,2971,51728,6621	GTF3C6,POLR2L,POLR2K,POLR3GL,CRCP,GTF3A,POLR3K,SNAPC4
R-HSA-5620924	Intraflagellar transport	0.361604869180086	-1.01720318490188	41	8	0.00471698113207547	1696	10287	9371,23059,51668,255758,8655,22920,11020,56912	KIF3B,CLUAP1,HSPB11,TCTEX1D2,DYNLL1,KIFAP3,IFT27,IFT46
R-HSA-74158	RNA Polymerase III Transcription	0.361604869180086	-1.01720318490188	41	8	0.00471698113207547	1696	10287	112495,5441,5440,84265,27297,2971,51728,6621	GTF3C6,POLR2L,POLR2K,POLR3GL,CRCP,GTF3A,POLR3K,SNAPC4
R-HSA-1502540	Signaling by Activin	0.364996613576519	-1.00786720331524	13	3	0.0017688679245283	1696	10287	4087,4089,10589	SMAD2,SMAD4,DRAP1
R-HSA-5210891	Uptake and function of anthrax toxins	0.364996613576519	-1.00786720331524	13	3	0.0017688679245283	1696	10287	805,10015,5605	CALM2,PDCD6IP,MAP2K2
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.364996613576519	-1.00786720331524	13	3	0.0017688679245283	1696	10287	163,1212,1175	AP2B1,CLTB,AP2S1
R-HSA-1663150	The activation of arylsulfatases	0.364996613576519	-1.00786720331524	13	3	0.0017688679245283	1696	10287	285362,25870,153642	SUMF1,SUMF2,ARSK
R-HSA-1483249	Inositol phosphate metabolism	0.368610077305711	-0.998015894712341	47	9	0.00530660377358491	1696	10287	805,5728,3632,11163,51447,9562,55190,11165,3613	CALM2,PTEN,INPP5A,NUDT4,IP6K2,MINPP1,NUDT11,NUDT3,IMPA2
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	0.373139456832861	-0.985803050305151	30	6	0.0035377358490566	1696	10287	65264,7874,92912,11065,6233,8078	UBE2Z,USP7,UBE2Q2,UBE2C,RPS27A,USP5
R-HSA-8876725	Protein methylation	0.384628581423788	-0.95547713391422	19	4	0.00235849056603774	1696	10287	805,6187,79091,79823	CALM2,RPS2,METTL22,CAMKMT
R-HSA-196836	Vitamin C (ascorbate) metabolism	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	1528,6513	CYB5A,SLC2A1
R-HSA-164944	Nef and signal transduction	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	9844,5879	ELMO1,RAC1
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	387,5879	RHOA,RAC1
R-HSA-6787450	tRNA modification in the mitochondrion	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	84705,55687	GTPBP3,TRMU
R-HSA-196783	Coenzyme A biosynthesis	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	79717,60490	PPCS,PPCDC
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.389719381525405	-0.942328333397914	8	2	0.00117924528301887	1696	10287	387,9138	RHOA,ARHGEF1
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.393797631149164	-0.931918128160454	48	9	0.00530660377358491	1696	10287	102,51107,7410,5879,163,1212,83464,4067,1175	ADAM10,APH1A,VAV2,RAC1,AP2B1,CLTB,APH1B,LYN,AP2S1
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	0.393797631149164	-0.931918128160454	48	9	0.00530660377358491	1696	10287	406,4783,1408,8648,1385,5936,10498,10499,1390	ARNTL,NFIL3,CRY2,NCOA1,CREB1,RBM4,CARM1,NCOA2,CREM
R-HSA-1614635	Sulfur amino acid metabolism	0.396640058382743	-0.924726063501987	25	5	0.00294811320754717	1696	10287	2730,191,4548,84245,84890	GCLM,AHCY,MTR,MRI1,ADO
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.396640058382743	-0.924726063501987	25	5	0.00294811320754717	1696	10287	148022,3661,351,1660,23220	TICAM1,IRF3,APP,DHX9,DTX4
R-HSA-933542	TRAF6 mediated NF-kB activation	0.396640058382743	-0.924726063501987	25	5	0.00294811320754717	1696	10287	23586,57506,84282,351,1660	DDX58,MAVS,RNF135,APP,DHX9
R-HSA-499943	Synthesis and interconversion of nucleotide di- and triphosphates	0.396640058382743	-0.924726063501987	25	5	0.00294811320754717	1696	10287	6241,7295,2987,1503,6240	RRM2,TXN,GUK1,CTPS1,RRM1
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	0.396918915223535	-0.92402326292498	95	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.396918915223535	-0.92402326292498	95	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.396918915223535	-0.92402326292498	95	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.396918915223535	-0.92402326292498	95	17	0.0100235849056604	1696	10287	7867,6195,1660,8454,4205,7335,2002,1432,351,5595,5515,6233,23118,1845,1385,5594,1386	MAPKAPK3,RPS6KA1,DHX9,CUL1,MEF2A,UBE2V1,ELK1,MAPK14,APP,MAPK3,PPP2CA,RPS27A,TAB2,DUSP3,CREB1,MAPK1,ATF2
R-HSA-422475	Axon guidance	0.402828495686359	-0.909244376632128	549	93	0.0548349056603774	1696	10287	391,10154,375790,102,4763,6195,5894,10096,288,5879,4627,1457,5361,5566,4067,5621,805,1020,27,5906,5707,5687,6464,998,6477,1808,5296,1785,163,1212,1072,4893,143471,4690,9978,51107,5695,8452,7430,5698,1809,5515,5525,3716,6233,5714,3984,5709,3688,60,6093,5536,409,5594,5700,1175,103910,8650,389,7204,7410,8649,6383,8315,83464,5715,23396,5708,2261,7408,10092,5781,1385,8128,11313,818,6709,387,5682,3845,23365,10552,5605,5691,388,5595,5704,782,1445,84078,6478,5306,3265	RHOG,PLXNC1,AGRN,ADAM10,NF1,RPS6KA1,RAF1,ACTR3,ANK3,RAC1,MYH9,CSNK2A1,PLXNA1,PRKACA,LYN,PRNP,CALM2,CDK5,ABL2,RAP1A,PSMD1,PSMA6,SHC1,CDC42,SIAH1,DPYSL2,PIK3R2,DNM2,AP2B1,CLTB,CFL1,NRAS,PSMA8,NCK1,RBX1,APH1A,PSMB7,CUL3,EZR,PSMB9,DPYSL3,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,LIMK1,PSMD3,ITGB1,ACTB,ROCK1,PPP5C,ARRB2,MAPK1,PSMC1,AP2S1,MYL12B,NUMB,RHOC,TRIO,VAV2,LAMTOR3,SDC2,BRAP,APH1B,PSMD9,PIP5K1C,PSMD2,FGFR3,VASP,ARPC5,PTPN11,CREB1,ST8SIA2,LYPLA2,CAMK2G,SPTAN1,RHOA,PSMA1,KRAS,ARHGEF12,ARPC1A,MAP2K2,PSMB3,RHOB,MAPK3,PSMC4,CACNB1,CSK,KBTBD7,SIAH2,PITPNA,HRAS
R-HSA-1257604	PIP3 activates AKT signaling	0.404662324967813	-0.904702325162958	125	22	0.0129716981132075	1696	10287	5170,7249,208,27161,79837,84335,2309,5305,5595,23396,7409,5515,2261,4193,5525,5728,5296,5781,1027,1385,5594,64223	PDPK1,TSC2,AKT2,AGO2,PIP4K2C,AKT1S1,FOXO3,PIP4K2A,MAPK3,PIP5K1C,VAV1,PPP2CA,FGFR3,MDM2,PPP2R5A,PTEN,PIK3R2,PTPN11,CDKN1B,CREB1,MAPK1,MLST8
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.404846494054611	-0.904247310750149	31	6	0.0035377358490566	1696	10287	5515,8569,5594,6233,5595,5781	PPP2CA,MKNK1,MAPK1,RPS27A,MAPK3,PTPN11
R-HSA-2129379	Molecules associated with elastic fibres	0.404846494054611	-0.904247310750149	31	6	0.0035377358490566	1696	10287	7040,8425,3696,3693,4236,3688	TGFB1,LTBP4,ITGB8,ITGB5,MFAP1,ITGB1
R-HSA-1679131	Trafficking and processing of endosomal TLR	0.413202947448014	-0.88381640853844	14	3	0.0017688679245283	1696	10287	1514,1520,10695	CTSL,CTSS,CNPY3
R-HSA-418359	Reduction of cytosolic Ca++ levels	0.413202947448014	-0.88381640853844	14	3	0.0017688679245283	1696	10287	805,488,6717	CALM2,ATP2A2,SRI
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	0.413202947448014	-0.88381640853844	14	3	0.0017688679245283	1696	10287	200576,9110,55361	PIKFYVE,MTMR4,PI4K2A
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	0.415425257788003	-0.878452565854635	43	8	0.00471698113207547	1696	10287	2778,2788,115,5575,5566,2783,8766,113	GNAS,GNG7,ADCY9,PRKAR1B,PRKACA,GNB2,RAB11A,ADCY7
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	57120	GOPC
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	4121	MAN1A1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	3032	HADHB
R-HSA-111458	Formation of apoptosome	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	54205	CYCS
R-HSA-73843	5-Phosphoribose 1-diphosphate biosynthesis	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	5634	PRPS2
R-HSA-198745	Signalling to STAT3	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	6774	STAT3
R-HSA-177539	Autointegration results in viral DNA circles	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	8815	BANF1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	3032	HADHB
R-HSA-8875791	MET activates STAT3	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	6774	STAT3
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	8655	DYNLL1
R-HSA-5357572	Lysosomal glycogen catabolism	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	2992	GYG1
R-HSA-3249367	STAT6-mediated induction of chemokines	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	6778	STAT6
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	7360	UGP2
R-HSA-6806664	Metabolism of vitamin K	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	79001	VKORC1
R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	292	SLC25A5
R-HSA-175567	Integration of viral DNA into host genomic DNA	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	8815	BANF1
R-HSA-5602571	TRAF3 deficiency - HSE	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	148022	TICAM1
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	8566	PDXK
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	890	CCNA2
R-HSA-162699	Synthesis of dolichyl-phosphate mannose	0.417575105403275	-0.873290857688569	3	1	0.000589622641509434	1696	10287	8813	DPM1
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.420356567173713	-0.86665195841424	126	22	0.0129716981132075	1696	10287	5438,3015,5436,5441,5440,23512,5433,10664,11091,58508,79447,94239,5430,9125,5439,63925,9063,3014,57472,7528,3020,5928	POLR2I,H2AFZ,POLR2G,POLR2L,POLR2K,SUZ12,POLR2D,CTCF,WDR5,KMT2C,PAGR1,H2AFV,POLR2A,CNOT9,POLR2J,ZNF335,PIAS2,H2AFX,CNOT6,YY1,H3F3A,RBBP4
R-HSA-5619507	Activation of HOX genes during differentiation	0.420356567173713	-0.86665195841424	126	22	0.0129716981132075	1696	10287	5438,3015,5436,5441,5440,23512,5433,10664,11091,58508,79447,94239,5430,9125,5439,63925,9063,3014,57472,7528,3020,5928	POLR2I,H2AFZ,POLR2G,POLR2L,POLR2K,SUZ12,POLR2D,CTCF,WDR5,KMT2C,PAGR1,H2AFV,POLR2A,CNOT9,POLR2J,ZNF335,PIAS2,H2AFX,CNOT6,YY1,H3F3A,RBBP4
R-HSA-114608	Platelet degranulation	0.421151514283894	-0.864762618634461	132	23	0.013561320754717	1696	10287	7040,51571,9948,5552,22927,29789,54495,351,78991,83706,805,10916,334,27154,10447,308,8407,51706,5660,1191,139322,66005,1072	TGFB1,FAM49B,WDR1,SRGN,HABP4,OLA1,TMX3,APP,PCYOX1L,FERMT3,CALM2,MAGED2,APLP2,BRPF3,FAM3C,ANXA5,TAGLN2,CYB5R1,PSAP,CLU,APOOL,CHID1,CFL1
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	0.424749505881629	-0.856255681746537	20	4	0.00235849056603774	1696	10287	7335,7867,23118,1432	UBE2V1,MAPKAPK3,TAB2,MAPK14
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.424749505881629	-0.856255681746537	20	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-194223	HDL-mediated lipid transport	0.424749505881629	-0.856255681746537	20	4	0.00235849056603774	1696	10287	949,5566,29801,19	SCARB1,PRKACA,ZDHHC8,ABCA1
R-HSA-8876384	Listeria monocytogenes entry into host cells	0.424749505881629	-0.856255681746537	20	4	0.00235849056603774	1696	10287	79872,9146,6233,8027	CBLL1,HGS,RPS27A,STAM
R-HSA-3000170	Syndecan interactions	0.424749505881629	-0.856255681746537	20	4	0.00235849056603774	1696	10287	7040,3693,3688,6383	TGFB1,ITGB5,ITGB1,SDC2
R-HSA-8848021	Signaling by PTK6	0.426392169322147	-0.852395770928244	67	12	0.00707547169811321	1696	10287	387,4893,4763,9844,6233,5879,116985,1027,3845,1017,6774,3265	RHOA,NRAS,NF1,ELMO1,RPS27A,RAC1,ARAP1,CDKN1B,KRAS,CDK2,STAT3,HRAS
R-HSA-193704	p75 NTR receptor-mediated signalling	0.432835016427051	-0.83739864800579	97	17	0.0100235849056604	1696	10287	6868,387,26574,51107,10276,9500,7410,5879,7204,23365,83464,7409,6233,9138,11108,9181,3066	ADAM17,RHOA,AATF,APH1A,NET1,MAGED1,VAV2,RAC1,TRIO,ARHGEF12,APH1B,VAV1,RPS27A,ARHGEF1,PRDM4,ARHGEF2,HDAC2
R-HSA-70171	Glycolysis	0.436421545457274	-0.829146655349911	32	6	0.0035377358490566	1696	10287	5515,5209,2821,5315,5223,5214	PPP2CA,PFKFB3,GPI,PKM,PGAM1,PFKP
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	0.439055967987203	-0.823128384312809	271	46	0.027122641509434	1696	10287	4763,5894,8649,8315,5566,5715,4067,1399,805,7409,2261,5708,5906,5707,5687,6464,5296,5781,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5714,5709,84078,7534,5536,409,5594,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PRKACA,PSMD9,LYN,CRKL,CALM2,VAV1,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD8,PSMD3,KBTBD7,YWHAZ,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.439785407872045	-0.82146838042045	38	7	0.00412735849056604	1696	10287	847,54205,7295,10935,25824,30001,5052	CAT,CYCS,TXN,PRDX3,PRDX5,ERO1A,PRDX1
R-HSA-5683057	MAPK family signaling cascades	0.449398945822925	-0.799844264977039	290	49	0.0288915094339623	1696	10287	4763,5894,27161,5879,8649,8315,3337,5566,5715,2309,805,2261,5708,5906,5707,5687,6464,998,3572,5781,818,6709,4893,143471,9978,8452,5695,5682,3845,989,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5714,5709,5597,84078,5536,409,5594,5700,3265	NF1,RAF1,AGO2,RAC1,LAMTOR3,BRAP,DNAJB1,PRKACA,PSMD9,FOXO3,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CDC42,IL6ST,PTPN11,CAMK2G,SPTAN1,NRAS,PSMA8,RBX1,CUL3,PSMB7,PSMA1,KRAS,SEPT7,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD8,PSMD3,MAPK6,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	4041,8323	LRP5,FZD6
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	57128,51312	LYRM4,SLC25A37
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	596,598	BCL2,BCL2L1
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	8575,27161	PRKRA,AGO2
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	5445,2879	PON2,GPX4
R-HSA-428543	Inactivation of Cdc42 and Rac	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	998,5879	CDC42,RAC1
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	6233,116985	RPS27A,ARAP1
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	79872,6233	CBLL1,RPS27A
R-HSA-193697	p75NTR regulates axonogenesis	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	387,9138	RHOA,ARHGEF1
R-HSA-196025	Formation of annular gap junctions	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	1212,1785	CLTB,DNM2
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	0.451357774368918	-0.795494962685046	9	2	0.00117924528301887	1696	10287	6888,7086	TALDO1,TKT
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	215,60481,51	ABCD1,ELOVL5,ACOX1
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	215,60481,51	ABCD1,ELOVL5,ACOX1
R-HSA-3371568	Attenuation phase	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	3337,10728,3304	DNAJB1,PTGES3,HSPA1B
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	9146,6233,8027	HGS,RPS27A,STAM
R-HSA-170670	Adenylate cyclase inhibitory pathway	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	2771,115,113	GNAI2,ADCY9,ADCY7
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	5361,5879,23396	PLXNA1,RAC1,PIP5K1C
R-HSA-997269	Inhibition of adenylate cyclase pathway	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	2771,115,113	GNAI2,ADCY9,ADCY7
R-HSA-205043	NRIF signals cell death from the nucleus	0.460175146611863	-0.776148108463167	15	3	0.0017688679245283	1696	10287	51107,83464,6233	APH1A,APH1B,RPS27A
R-HSA-2024096	HS-GAG degradation	0.464171861580357	-0.767500403996842	21	4	0.00235849056603774	1696	10287	6448,375790,4669,6383	SGSH,AGRN,NAGLU,SDC2
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.464171861580357	-0.767500403996842	21	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-6807004	Negative regulation of MET activity	0.464171861580357	-0.767500403996842	21	4	0.00235849056603774	1696	10287	5771,9146,6233,8027	PTPN2,HGS,RPS27A,STAM
R-HSA-1181150	Signaling by NODAL	0.464171861580357	-0.767500403996842	21	4	0.00235849056603774	1696	10287	4087,2309,4089,10589	SMAD2,FOXO3,SMAD4,DRAP1
R-HSA-5654716	Downstream signaling of activated FGFR4	0.46636456989841	-0.762787611886213	27	5	0.00294811320754717	1696	10287	3845,4893,6464,3265,5781	KRAS,NRAS,SHC1,HRAS,PTPN11
R-HSA-6783589	Interleukin-6 family signaling	0.46636456989841	-0.762787611886213	27	5	0.00294811320754717	1696	10287	3716,6774,3572,6772,5781	JAK1,STAT3,IL6ST,STAT1,PTPN11
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.467676723920972	-0.759977982602316	33	6	0.0035377358490566	1696	10287	5515,8569,5594,6233,5595,5781	PPP2CA,MKNK1,MAPK1,RPS27A,MAPK3,PTPN11
R-HSA-163685	Integration of energy metabolism	0.468315360371832	-0.758613363049046	111	19	0.0112028301886792	1696	10287	2788,6513,5575,7086,10554,292,5566,2783,2778,5515,5906,6945,115,47,6794,10768,6888,2771,113	GNG7,SLC2A1,PRKAR1B,TKT,AGPAT1,SLC25A5,PRKACA,GNB2,GNAS,PPP2CA,RAP1A,MLX,ADCY9,ACLY,STK11,AHCYL1,TALDO1,GNAI2,ADCY7
R-HSA-909733	Interferon alpha/beta signaling	0.469496364485536	-0.756094723738591	69	12	0.00707547169811321	1696	10287	3106,3662,3716,3133,6772,5781,3661,6041,51447,9636,3663,3105	HLA-B,IRF4,JAK1,HLA-E,STAT1,PTPN11,IRF3,RNASEL,IP6K2,ISG15,IRF5,HLA-A
R-HSA-187687	Signalling to ERKs	0.483494603408409	-0.726715125664193	263	44	0.0259433962264151	1696	10287	4763,5894,8649,8315,5715,1432,1399,805,2261,5708,5906,5707,5687,6464,5899,818,6709,4893,7867,9978,143471,8452,5695,5682,3845,6016,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5714,5709,84078,5536,409,5594,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,MAPK14,CRKL,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,RALB,CAMK2G,SPTAN1,NRAS,MAPKAPK3,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,RIT1,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD8,PSMD3,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-877300	Interferon gamma signaling	0.487411812914747	-0.71864590149313	94	16	0.00943396226415094	1696	10287	81603,3133,3661,3663,3105,5771,3662,3106,7726,3716,6672,5781,5371,6772,9830,818	TRIM8,HLA-E,IRF3,IRF5,HLA-A,PTPN2,IRF4,HLA-B,TRIM26,JAK1,SP100,PTPN11,PML,STAT1,TRIM14,CAMK2G
R-HSA-5693606	DNA Double Strand Break Response	0.489933307845621	-0.713486003578295	76	13	0.00766509433962264	1696	10287	9577,9682,6233,2138,29086,3014,9031,3838,672,11200,5536,7329,2139	BABAM2,KDM4A,RPS27A,EYA1,BABAM1,H2AFX,BAZ1B,KPNA2,BRCA1,CHEK2,PPP5C,UBE2I,EYA2
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.489933307845621	-0.713486003578295	76	13	0.00766509433962264	1696	10287	7409,26574,51107,6233,10276,9500,7410,9138,5879,7204,9181,23365,83464	VAV1,AATF,APH1A,RPS27A,NET1,MAGED1,VAV2,ARHGEF1,RAC1,TRIO,ARHGEF2,ARHGEF12,APH1B
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.497918050689173	-0.697319772347499	137	23	0.013561320754717	1696	10287	7040,51571,9948,5552,22927,29789,54495,351,78991,83706,805,10916,334,27154,10447,308,8407,51706,5660,1191,139322,66005,1072	TGFB1,FAM49B,WDR1,SRGN,HABP4,OLA1,TMX3,APP,PCYOX1L,FERMT3,CALM2,MAGED2,APLP2,BRPF3,FAM3C,ANXA5,TAGLN2,CYB5R1,PSAP,CLU,APOOL,CHID1,CFL1
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.498442029761741	-0.696267985686926	34	6	0.0035377358490566	1696	10287	5515,8569,5594,6233,5595,5781	PPP2CA,MKNK1,MAPK1,RPS27A,MAPK3,PTPN11
R-HSA-264876	Insulin processing	0.500322083307773	-0.692503221330658	28	5	0.00294811320754717	1696	10287	3799,11336,4644,30001,60412	KIF5B,EXOC3,MYO5A,ERO1A,EXOC4
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	0.500322083307773	-0.692503221330658	28	5	0.00294811320754717	1696	10287	51703,60481,9524,5538,2181	ACSL5,ELOVL5,TECR,PPT1,ACSL3
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	10898,8189,10914,1477	CPSF4,SYMPK,PAPOLA,CSTF1
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	3845,2261,4893,3265	KRAS,FGFR3,NRAS,HRAS
R-HSA-5655332	Signaling by FGFR3 in disease	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	3845,2261,4893,3265	KRAS,FGFR3,NRAS,HRAS
R-HSA-4641263	Regulation of FZD by ubiquitination	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	4041,84133,6233,8323	LRP5,ZNRF3,RPS27A,FZD6
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	3845,4893,3265,5781	KRAS,NRAS,HRAS,PTPN11
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	1666,34,4594,3032	DECR1,ACADM,MUT,HADHB
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.502584273818899	-0.687991944018168	22	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-373760	L1CAM interactions	0.504428030288706	-0.684330104887622	101	17	0.0100235849056604	1696	10287	6195,7410,288,5879,7430,1457,5605,5595,1808,1785,3688,163,5594,1175,11313,8650,6709	RPS6KA1,VAV2,ANK3,RAC1,EZR,CSNK2A1,MAP2K2,MAPK3,DPYSL2,DNM2,ITGB1,AP2B1,MAPK1,AP2S1,LYPLA2,NUMB,SPTAN1
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.50544097341936	-0.682324016045126	16	3	0.0017688679245283	1696	10287	5925,23523,29855	RB1,CABIN1,UBN1
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.50544097341936	-0.682324016045126	16	3	0.0017688679245283	1696	10287	3845,4893,3265	KRAS,NRAS,HRAS
R-HSA-1170546	Prolactin receptor signaling	0.50544097341936	-0.682324016045126	16	3	0.0017688679245283	1696	10287	8454,9978,5781	CUL1,RBX1,PTPN11
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.50544097341936	-0.682324016045126	16	3	0.0017688679245283	1696	10287	148022,23118,6233	TICAM1,TAB2,RPS27A
R-HSA-69473	G2/M DNA damage checkpoint	0.505739488398247	-0.68173358733565	95	16	0.00943396226415094	1696	10287	6118,9577,5983,29086,3014,116028,7156,7534,672,11200,891,641,5982,7533,80010,6117	RPA2,BABAM2,RFC3,BABAM1,H2AFX,RMI2,TOP3A,YWHAZ,BRCA1,CHEK2,CCNB1,BLM,RFC2,YWHAH,RMI1,RPA1
R-HSA-535734	Fatty acid, triacylglycerol, and ketone body metabolism	0.507192560743408	-0.678864543270693	253	42	0.0247641509433962	1696	10287	892,9612,4594,10554,23389,56894,9967,253558,1666,4899,112950,84246,622,9663,3032,9524,23171,79888,10499,10498,6837,6576,2222,51703,60481,5538,65985,2181,58526,10555,51,406,51586,1622,47,254531,38,8648,23179,34,19,80221	CCNC,NCOR2,MUT,AGPAT1,MED13L,AGPAT3,THRAP3,LCLAT1,DECR1,NRF1,MED8,MED10,BDH1,LPIN2,HADHB,TECR,GPD1L,LPCAT1,NCOA2,CARM1,MED22,SLC25A1,FDFT1,ACSL5,ELOVL5,PPT1,AACS,ACSL3,MID1IP1,AGPAT2,ACOX1,ARNTL,MED15,DBI,ACLY,LPCAT4,ACAT1,NCOA1,RGL1,ACADM,ABCA1,ACSF2
R-HSA-428643	Organic anion transporters	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	79751,26503	SLC25A22,SLC17A5
R-HSA-8875656	MET receptor recycling	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	1399,5867	CRKL,RAB4A
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	5564,1432	PRKAB1,MAPK14
R-HSA-196108	Pregnenolone biosynthesis	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	231,83930	AKR1B1,STARD3NL
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	200576,9110	PIKFYVE,MTMR4
R-HSA-975578	Reactions specific to the complex N-glycan synthesis pathway	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	4122,2530	MAN2A2,FUT8
R-HSA-389887	Beta-oxidation of pristanoyl-CoA	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	390916,1384	NUDT19,CRAT
R-HSA-430116	GP1b-IX-V activation signalling	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	7534,5894	YWHAZ,RAF1
R-HSA-2562578	TRIF-mediated programmed cell death	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	148022,8772	TICAM1,FADD
R-HSA-1300644	Interaction With The Zona Pellucida	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	2683,7784	B4GALT1,ZP3
R-HSA-427601	Multifunctional anion exchangers	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	1836,65010	SLC26A2,SLC26A6
R-HSA-170660	Adenylate cyclase activating pathway	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	115,113	ADCY9,ADCY7
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	34,3032	ACADM,HADHB
R-HSA-2046105	Linoleic acid (LA) metabolism	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	215,60481	ABCD1,ELOVL5
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	23118,6233	TAB2,RPS27A
R-HSA-190873	Gap junction degradation	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	1212,1785	CLTB,DNM2
R-HSA-5687613	Diseases associated with surfactant metabolism	0.509271956076232	-0.674773110271035	10	2	0.00117924528301887	1696	10287	7270,29080	TTF1,CCDC59
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	3688	ITGB1
R-HSA-5083630	Defective LFNG causes SCDO3	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	4853	NOTCH2
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	200424	TET3
R-HSA-447115	Interleukin-12 signaling	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	3594	IL12RB1
R-HSA-8849474	PTK6 Activates STAT3	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	6774	STAT3
R-HSA-6783984	Glycine degradation	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	2653	GCSH
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	208	AKT2
R-HSA-6807062	Cholesterol biosynthesis via lathosterol	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	10682	EBP
R-HSA-1855191	Synthesis of IPs in the nucleus	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	51447	IP6K2
R-HSA-1369007	Mitochondrial ABC transporters	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	23456	ABCB10
R-HSA-209563	Axonal growth stimulation	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	387	RHOA
R-HSA-6807047	Cholesterol biosynthesis via desmosterol	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	10682	EBP
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	2992	GYG1
R-HSA-75944	Transcription from mitochondrial promoters	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	7978	MTERF1
R-HSA-442745	Activation of CaMK IV	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	805	CALM2
R-HSA-8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	0.513626507699148	-0.666258916374454	4	1	0.000589622641509434	1696	10287	10370	CITED2
R-HSA-109582	Hemostasis	0.5264245394258	-0.641647282607362	632	104	0.0613207547169811	1696	10287	391,5894,5879,29789,3661,11004,5566,1432,4067,2783,351,78991,3833,805,1020,7409,334,5906,6464,488,998,27154,5296,6717,3835,51706,81928,139322,2149,55604,1072,80228,4893,208,6404,2788,56992,3796,5515,5889,5525,3716,146909,2983,7975,3688,1191,3020,409,5594,7804,66005,3066,4282,9371,5552,22927,7410,11311,54495,6383,9493,3831,29127,139818,83706,3799,23303,23759,829,5781,84876,308,22920,8407,2771,5170,7040,387,51571,9948,5575,23186,3845,830,5140,3832,388,5595,9927,8165,10916,2778,2768,81930,1445,10447,2734,6566,7534,5660,1017,3265,91768	RHOG,RAF1,RAC1,OLA1,IRF3,KIF2C,PRKACA,MAPK14,LYN,GNB2,APP,PCYOX1L,KIFC1,CALM2,CDK5,VAV1,APLP2,RAP1A,SHC1,ATP2A2,CDC42,BRPF3,PIK3R2,SRI,KIF22,CYB5R1,CABLES2,APOOL,F2R,CARMIL1,CFL1,ORAI2,NRAS,AKT2,SELPLG,GNG7,KIF15,KIF2A,PPP2CA,RAD51C,PPP2R5A,JAK1,KIF18B,GUCY1B1,MAFK,ITGB1,CLU,H3F3A,ARRB2,MAPK1,LRP8,CHID1,HDAC2,MIF,KIF3B,SRGN,HABP4,VAV2,VPS45,TMX3,SDC2,KIF23,KLC1,RACGAP1,DOCK11,FERMT3,KIF5B,KIF13B,PPIL2,CAPZA1,PTPN11,ORAI1,ANXA5,KIFAP3,TAGLN2,GNAI2,PDPK1,TGFB1,RHOA,FAM49B,WDR1,PRKAR1B,RCOR1,KRAS,CAPZA2,PDE3B,KIF11,RHOB,MAPK3,MFN2,AKAP1,MAGED2,GNAS,GNA12,KIF18A,CSK,FAM3C,GLG1,SLC16A1,YWHAZ,PSAP,CDK2,HRAS,CABLES1
R-HSA-933541	TRAF6 mediated IRF7 activation	0.528566342168398	-0.637586952376087	35	6	0.0035377358490566	1696	10287	23586,80143,3661,57506,84282,10010	DDX58,SIKE1,IRF3,MAVS,RNF135,TANK
R-HSA-4791275	Signaling by WNT in cancer	0.528566342168398	-0.637586952376087	35	6	0.0035377358490566	1696	10287	5515,4041,5525,1452,8312,8323	PPP2CA,LRP5,PPP2R5A,CSNK1A1,AXIN1,FZD6
R-HSA-1500620	Meiosis	0.533380505170619	-0.628520216138686	121	20	0.0117924528301887	1696	10287	84057,3015,7156,672,11083,641,7329,94239,4000,6117,54386,6118,5889,9126,3014,3020,1017,7013,25913,7014	MND1,H2AFZ,TOP3A,BRCA1,DIDO1,BLM,UBE2I,H2AFV,LMNA,RPA1,TERF2IP,RPA2,RAD51C,SMC3,H2AFX,H3F3A,CDK2,TERF1,POT1,TERF2
R-HSA-389957	Prefoldin mediated transfer of substrate  to CCT/TriC	0.53340906098701	-0.628466680151263	29	5	0.00294811320754717	1696	10287	10576,60,5204,5203,10694	CCT2,ACTB,PFDN5,PFDN4,CCT8
R-HSA-193648	NRAGE signals death through JNK	0.539060098289605	-0.617928214679103	60	10	0.00589622641509434	1696	10287	7409,26574,10276,9500,7410,9138,5879,7204,9181,23365	VAV1,AATF,NET1,MAGED1,VAV2,ARHGEF1,RAC1,TRIO,ARHGEF2,ARHGEF12
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.539730485654945	-0.616685364654989	23	4	0.00235849056603774	1696	10287	3845,4893,3265,5781	KRAS,NRAS,HRAS,PTPN11
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.539730485654945	-0.616685364654989	23	4	0.00235849056603774	1696	10287	3845,4893,6464,3265	KRAS,NRAS,SHC1,HRAS
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	0.539730485654945	-0.616685364654989	23	4	0.00235849056603774	1696	10287	10576,117177,10694,166379	CCT2,RAB3IP,CCT8,BBS12
R-HSA-167044	Signalling to RAS	0.540815220453314	-0.614677610320073	256	42	0.0247641509433962	1696	10287	4763,5894,8649,8315,5715,1432,805,2261,5708,5906,5707,5687,6464,5899,818,6709,4893,7867,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,409,5594,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,MAPK14,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,RALB,CAMK2G,SPTAN1,NRAS,MAPKAPK3,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-418346	Platelet homeostasis	0.544458075276806	-0.607964336310334	91	15	0.00884433962264151	1696	10287	805,5515,2778,80228,5525,488,2983,2788,5781,6717,84876,5140,1432,7804,2783	CALM2,PPP2CA,GNAS,ORAI2,PPP2R5A,ATP2A2,GUCY1B1,GNG7,PTPN11,SRI,ORAI1,PDE3B,MAPK14,LRP8,GNB2
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	0.546928408728566	-0.603437364963757	48	8	0.00471698113207547	1696	10287	5170,387,6464,3716,208,2788,5296,2783	PDPK1,RHOA,SHC1,JAK1,AKT2,GNG7,PIK3R2,GNB2
R-HSA-937072	TRAF6 mediated induction of TAK1 complex	0.548646143320759	-0.600301592968086	17	3	0.0017688679245283	1696	10287	148022,23118,6233	TICAM1,TAB2,RPS27A
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	0.548646143320759	-0.600301592968086	17	3	0.0017688679245283	1696	10287	805,1385,818	CALM2,CREB1,CAMK2G
R-HSA-189445	Metabolism of porphyrins	0.548646143320759	-0.600301592968086	17	3	0.0017688679245283	1696	10287	1355,1371,7389	COX15,CPOX,UROD
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	0.548646143320759	-0.600301592968086	17	3	0.0017688679245283	1696	10287	163,4905,1175	AP2B1,NSF,AP2S1
R-HSA-70221	Glycogen breakdown (glycogenolysis)	0.548646143320759	-0.600301592968086	17	3	0.0017688679245283	1696	10287	805,2992,5261	CALM2,GYG1,PHKG2
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.549393995081757	-0.598939435337454	122	20	0.0117924528301887	1696	10287	55191,25974,79717,4594,6513,143,56922,4548,51293,1528,80308,6573,10797,60490,60386,128240,200895,8566,84875,4363	NADSYN1,MMACHC,PPCS,MUT,SLC2A1,PARP4,MCCC1,MTR,CD320,CYB5A,FLAD1,SLC19A1,MTHFD2,PPCDC,SLC25A19,NAXE,DHFR2,PDXK,PARP10,ABCC1
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.550267812967799	-0.597350186600137	79	13	0.00766509433962264	1696	10287	54386,5925,890,3015,29855,3014,1027,23523,1017,94239,7013,25913,7014	TERF2IP,RB1,CCNA2,H2AFZ,UBN1,H2AFX,CDKN1B,CABIN1,CDK2,H2AFV,TERF1,POT1,TERF2
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.551900252134786	-0.594387951688107	42	7	0.00412735849056604	1696	10287	7323,9646,54623,23168,6233,5591,79577	UBE2D3,CTR9,PAF1,RTF1,RPS27A,PRKDC,CDC73
R-HSA-5684996	MAPK1/MAPK3 signaling	0.553237646796804	-0.591967628728994	251	41	0.0241745283018868	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,3572,5781,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,IL6ST,PTPN11,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-376172	DSCAM interactions	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	1432,5879	MAPK14,RAC1
R-HSA-2470946	Cohesin Loading onto Chromatin	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	9126,23047	SMC3,PDS5B
R-HSA-174490	Membrane binding and targetting of GAG proteins	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	6233,9397	RPS27A,NMT2
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	6233,9397	RPS27A,NMT2
R-HSA-446107	Type I hemidesmosome assembly	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	667,5339	DST,PLEC
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	0.563014122680252	-0.574450566467449	11	2	0.00117924528301887	1696	10287	3632,3613	INPP5A,IMPA2
R-HSA-8863795	Downregulation of ERBB2 signaling	0.565462981820682	-0.570110446540009	30	5	0.00294811320754717	1696	10287	55914,26469,6233,208,11140	ERBIN,PTPN18,RPS27A,AKT2,CDC37
R-HSA-5654696	Downstream signaling of activated FGFR2	0.565462981820682	-0.570110446540009	30	5	0.00294811320754717	1696	10287	3845,4893,6464,3265,5781	KRAS,NRAS,SHC1,HRAS,PTPN11
R-HSA-75105	Fatty Acyl-CoA Biosynthesis	0.566334698962905	-0.568570034628241	55	9	0.00530660377358491	1696	10287	51703,60481,5538,2181,1622,47,9524,80221,6576	ACSL5,ELOVL5,PPT1,ACSL3,DBI,ACLY,TECR,ACSF2,SLC25A1
R-HSA-2871796	FCERI mediated MAPK activation	0.572352226686197	-0.558000696197688	265	43	0.0253537735849057	1696	10287	4763,5894,7410,5879,8649,8315,5715,4067,805,7409,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5714,5709,84078,5536,409,5594,5700,3265	NF1,RAF1,VAV2,RAC1,LAMTOR3,BRAP,PSMD9,LYN,CALM2,VAV1,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD8,PSMD3,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-201451	Signaling by BMP	0.575406628188005	-0.552678308660955	24	4	0.00235849056603774	1696	10287	7323,4086,57154,4089	UBE2D3,SMAD1,SMURF1,SMAD4
R-HSA-2586552	Signaling by Leptin	0.575439089749121	-0.552621895258846	253	41	0.0241745283018868	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,5781,6774,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PTPN11,STAT3,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-5625740	RHO GTPases activate PKNs	0.580810535173759	-0.543330676562786	93	15	0.00884433962264151	1696	10287	5170,3015,387,4659,389,5879,3014,4627,7534,3020,7533,94239,103910,10499,388	PDPK1,H2AFZ,RHOA,PPP1R12A,RHOC,RAC1,H2AFX,MYH9,YWHAZ,H3F3A,YWHAH,H2AFV,MYL12B,NCOA2,RHOB
R-HSA-1630316	Glycosaminoglycan metabolism	0.580878896674025	-0.543212983316258	124	20	0.0117924528301887	1696	10287	126792,375790,9334,3074,6383,2683,347734,8702,2132,2799,6448,4669,6483,1836,8703,3073,54480,8704,10057,11261	B3GALT6,AGRN,B4GALT5,HEXB,SDC2,B4GALT1,SLC35B2,B4GALT4,EXT2,GNS,SGSH,NAGLU,ST3GAL2,SLC26A2,B4GALT3,HEXA,CHPF2,B4GALT2,ABCC5,CHP1
R-HSA-3214847	HATs acetylate histones	0.587311311421065	-0.532200256599863	143	23	0.013561320754717	1696	10287	2648,11143,26610,55578,10629,23326,11091,9913,64769,79595,51562,27154,23587,8473,27097,54934,60,6883,10856,8648,1386,112869,10499	KAT2A,KAT7,ELP4,SUPT20H,TAF6L,USP22,WDR5,SUPT7L,MEAF6,SAP130,MBIP,BRPF3,ELP5,OGT,TAF5L,KANSL2,ACTB,TAF12,RUVBL2,NCOA1,ATF2,SGF29,NCOA2
R-HSA-5578775	Ion homeostasis	0.589421484452105	-0.528613757948063	56	9	0.00530660377358491	1696	10287	805,84876,80228,476,10768,488,5566,818,6717	CALM2,ORAI1,ORAI2,ATP1A1,AHCYL1,ATP2A2,PRKACA,CAMK2G,SRI
R-HSA-197264	Nicotinamide salvaging	0.589540025926287	-0.528412663215896	18	3	0.0017688679245283	1696	10287	128240,84875,143	NAXE,PARP10,PARP4
R-HSA-196757	Metabolism of folate and pterines	0.589540025926287	-0.528412663215896	18	3	0.0017688679245283	1696	10287	6573,200895,10797	SLC19A1,DHFR2,MTHFD2
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.589540025926287	-0.528412663215896	18	3	0.0017688679245283	1696	10287	9020,330,329	MAP3K14,BIRC3,BIRC2
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.593808930824741	-0.521197676643078	75	12	0.00707547169811321	1696	10287	9577,9682,6233,2138,29086,3014,9031,672,11200,5536,7329,2139	BABAM2,KDM4A,RPS27A,EYA1,BABAM1,H2AFX,BAZ1B,BRCA1,CHEK2,PPP5C,UBE2I,EYA2
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	3032	HADHB
R-HSA-71262	Carnitine synthesis	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	223	ALDH9A1
R-HSA-2161541	Abacavir metabolism	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	2987	GUK1
R-HSA-3000471	Scavenging by Class B Receptors	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	949	SCARB1
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	331	XIAP
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	5566	PRKACA
R-HSA-2142850	Hyaluronan biosynthesis and export	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	10057	ABCC5
R-HSA-70370	Galactose catabolism	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	2584	GALK1
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	6574	SLC20A1
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	3032	HADHB
R-HSA-71032	Propionyl-CoA catabolism	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	4594	MUT
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	8815	BANF1
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	54205	CYCS
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	4121	MAN1A1
R-HSA-111463	SMAC binds to IAPs	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	331	XIAP
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	54205	CYCS
R-HSA-196819	Vitamin B1 (thiamin) metabolism	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	60386	SLC25A19
R-HSA-203641	NOSTRIN mediated eNOS trafficking	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	1785	DNM2
R-HSA-8865999	MET activates PTPN11	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-111469	SMAC-mediated apoptotic response	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	331	XIAP
R-HSA-1483226	Synthesis of PI	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	10423	CDIPT
R-HSA-3065676	SUMO is conjugated to E1 (UBA2:SAE1)	0.593845261268758	-0.521136496470819	5	1	0.000589622641509434	1696	10287	6613	SUMO2
R-HSA-5654687	Downstream signaling of activated FGFR1	0.596350767933918	-0.516926248234773	31	5	0.00294811320754717	1696	10287	3845,4893,6464,3265,5781	KRAS,NRAS,SHC1,HRAS,PTPN11
R-HSA-418360	Platelet calcium homeostasis	0.596350767933918	-0.516926248234773	31	5	0.00294811320754717	1696	10287	805,84876,80228,488,6717	CALM2,ORAI1,ORAI2,ATP2A2,SRI
R-HSA-8875878	MET promotes cell motility	0.596350767933918	-0.516926248234773	31	5	0.00294811320754717	1696	10287	1399,64759,5906,5879,3688	CRKL,TNS3,RAP1A,RAC1,ITGB1
R-HSA-1839124	FGFR1 mutant receptor activation	0.596350767933918	-0.516926248234773	31	5	0.00294811320754717	1696	10287	11116,6774,26127,399687,6772	FGFR1OP,STAT3,FGFR1OP2,MYO18A,STAT1
R-HSA-187706	Signalling to p38 via RIT and RIN	0.599123649158255	-0.512287276195884	249	40	0.0235849056603774	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,6016,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,RIT1,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-1251985	Nuclear signaling by ERBB4	0.609457403389205	-0.495186220297655	25	4	0.00235849056603774	1696	10287	6868,51107,23118,83464	ADAM17,APH1A,TAB2,APH1B
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.609457403389205	-0.495186220297655	25	4	0.00235849056603774	1696	10287	3845,4893,3265,5781	KRAS,NRAS,HRAS,PTPN11
R-HSA-389661	Glyoxylate metabolism and glycine degradation	0.609457403389205	-0.495186220297655	25	4	0.00235849056603774	1696	10287	55526,4967,8050,2653	DHTKD1,OGDH,PDHX,GCSH
R-HSA-170968	Frs2-mediated activation	0.610000162635506	-0.494296055199232	250	40	0.0235849056603774	1696	10287	4763,5894,8649,8315,5715,1399,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CRKL,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-3656237	Defective EXT2 causes exostoses 2	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-210990	PECAM1 interactions	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	4067,5781	LYN,PTPN11
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-8866427	VLDLR internalisation and degradation	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	163,1175	AP2B1,AP2S1
R-HSA-844456	The NLRP3 inflammasome	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	7295,351	TXN,APP
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.61238516211387	-0.490393844568118	12	2	0.00117924528301887	1696	10287	805,6697	CALM2,SPR
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.613285610136298	-0.48892452963492	76	12	0.00707547169811321	1696	10287	3015,1107,9112,9219,3014,3020,5928,53615,94239,7270,3066,11335	H2AFZ,CHD3,MTA1,MTA2,H2AFX,H3F3A,RBBP4,MBD3,H2AFV,TTF1,HDAC2,CBX3
R-HSA-5689901	Metalloprotease DUBs	0.613871317112387	-0.487969954050398	38	6	0.0035377358490566	1696	10287	672,9577,23172,6233,8027,29086	BRCA1,BABAM2,ABRAXAS2,RPS27A,STAM,BABAM1
R-HSA-397795	G-protein beta:gamma signalling	0.619802575498379	-0.478354278267037	51	8	0.00471698113207547	1696	10287	5170,387,6464,3716,208,2788,5296,2783	PDPK1,RHOA,SHC1,JAK1,AKT2,GNG7,PIK3R2,GNB2
R-HSA-180336	SHC1 events in EGFR signaling	0.6228795351537	-0.47340214140575	245	39	0.0229952830188679	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-5673001	RAF/MAP kinase cascade	0.6228795351537	-0.47340214140575	245	39	0.0229952830188679	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-179812	GRB2 events in EGFR signaling	0.6228795351537	-0.47340214140575	245	39	0.0229952830188679	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-112412	SOS-mediated signalling	0.6228795351537	-0.47340214140575	245	39	0.0229952830188679	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-375165	NCAM signaling for neurite out-growth	0.623147125322588	-0.472972631859142	276	44	0.0259433962264151	1696	10287	375790,4763,5894,8649,8315,5715,5621,805,2261,5708,5906,5707,5687,6464,1385,8128,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,782,5525,3716,6233,1445,5714,5709,84078,5536,409,5594,5700,3265	AGRN,NF1,RAF1,LAMTOR3,BRAP,PSMD9,PRNP,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CREB1,ST8SIA2,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,CACNB1,PPP2R5A,JAK1,RPS27A,CSK,PSMD8,PSMD3,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-399719	Trafficking of AMPA receptors	0.62596729062125	-0.468457160650945	32	5	0.00294811320754717	1696	10287	163,4193,4905,1175,818	AP2B1,MDM2,NSF,AP2S1,CAMK2G
R-HSA-399721	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.62596729062125	-0.468457160650945	32	5	0.00294811320754717	1696	10287	163,4193,4905,1175,818	AP2B1,MDM2,NSF,AP2S1,CAMK2G
R-HSA-376176	Signaling by Robo receptor	0.62596729062125	-0.468457160650945	32	5	0.00294811320754717	1696	10287	27,7408,998,4690,5879	ABL2,VASP,CDC42,NCK1,RAC1
R-HSA-416700	Other semaphorin interactions	0.627960921769026	-0.465277340932529	19	3	0.0017688679245283	1696	10287	5361,10154,3688	PLXNA1,PLXNC1,ITGB1
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	0.627960921769026	-0.465277340932529	19	3	0.0017688679245283	1696	10287	2778,2783,2788	GNAS,GNB2,GNG7
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.627960921769026	-0.465277340932529	19	3	0.0017688679245283	1696	10287	375,200576,55361	ARF1,PIKFYVE,PI4K2A
R-HSA-156584	Cytosolic sulfonation of small molecules	0.627960921769026	-0.465277340932529	19	3	0.0017688679245283	1696	10287	84836,1836,347734	ABHD14B,SLC26A2,SLC35B2
R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor	0.627960921769026	-0.465277340932529	19	3	0.0017688679245283	1696	10287	805,3265,818	CALM2,HRAS,CAMK2G
R-HSA-5218921	VEGFR2 mediated cell proliferation	0.629244363920601	-0.463235601827483	258	41	0.0241745283018868	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,10768,818,6709,5170,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,AHCYL1,CAMK2G,SPTAN1,PDPK1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-169893	Prolonged ERK activation events	0.631398839256183	-0.459817541225183	252	40	0.0235849056603774	1696	10287	4763,5894,8649,8315,5715,1399,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CRKL,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-2029485	Role of phospholipids in phagocytosis	0.641771583626237	-0.443522827344187	26	4	0.00235849056603774	1696	10287	23646,10768,5296,84513	PLD3,AHCYL1,PIK3R2,PLPP5
R-HSA-445717	Aquaporin-mediated transport	0.642654440985623	-0.442148116023323	52	8	0.00471698113207547	1696	10287	2778,2788,115,5575,5566,2783,8766,113	GNAS,GNG7,ADCY9,PRKAR1B,PRKACA,GNB2,RAB11A,ADCY7
R-HSA-425561	Sodium/Calcium exchangers	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	805,6717	CALM2,SRI
R-HSA-211227	Activation of DNA fragmentation factor	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	3148,3836	HMGB2,KPNA1
R-HSA-400511	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	23478,60559	SEC11A,SPCS3
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	351,1660	APP,DHX9
R-HSA-74217	Purine salvage	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	271,1633	AMPD2,DCK
R-HSA-1480926	O2/CO2 exchange in erythrocytes	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	51706,606495	CYB5R1,CYB5RL
R-HSA-140342	Apoptosis induced DNA fragmentation	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	3148,3836	HMGB2,KPNA1
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	6233,208	RPS27A,AKT2
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	51706,606495	CYB5R1,CYB5RL
R-HSA-75892	Platelet Adhesion to exposed collagen	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	4067,3688	LYN,ITGB1
R-HSA-175474	Assembly Of The HIV Virion	0.657364898204265	-0.419516014060044	13	2	0.00117924528301887	1696	10287	6233,9397	RPS27A,NMT2
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	3661	IRF3
R-HSA-6787639	GDP-fucose biosynthesis	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	7264	TSTA3
R-HSA-3323169	Defects in biotin (Btn) metabolism	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	56922	MCCC1
R-HSA-1237112	Methionine salvage pathway	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	84245	MRI1
R-HSA-5676934	Protein repair	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	7295	TXN
R-HSA-1566977	Fibronectin matrix formation	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	3688	ITGB1
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	3838	KPNA2
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	2879	GPX4
R-HSA-5690714	CD22 mediated BCR regulation	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	4067	LYN
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	56922	MCCC1
R-HSA-111957	Cam-PDE 1 activation	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	805	CALM2
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	2879	GPX4
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	6102	RP2
R-HSA-6798163	Choline catabolism	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	23446	SLC44A1
R-HSA-446199	Synthesis of Dolichyl-phosphate	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	116150	NUS1
R-HSA-5339717	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	4041	LRP5
R-HSA-3000484	Scavenging by Class F Receptors	0.660839857351569	-0.414243741779027	6	1	0.000589622641509434	1696	10287	10808	HSPH1
R-HSA-912526	Interleukin receptor SHC signaling	0.662513812825418	-0.411713871791308	255	40	0.0235849056603774	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,5296,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-170984	ARMS-mediated activation	0.66501287201178	-0.407948882104924	249	39	0.0229952830188679	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	0.665623935247594	-0.407030429713654	40	6	0.0035377358490566	1696	10287	10999,28231,2030,347734,10559,84912	SLC27A4,SLCO4A1,SLC29A1,SLC35B2,SLC35A1,SLC35B4
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.665623935247594	-0.407030429713654	40	6	0.0035377358490566	1696	10287	29028,7528,4839,10370,7329,4605	ATAD2,YY1,NOP2,CITED2,UBE2I,MYBL2
R-HSA-1221632	Meiotic synapsis	0.668840958443666	-0.402208977394757	79	12	0.00707547169811321	1696	10287	54386,3015,9126,3014,672,11083,7329,94239,7013,25913,4000,7014	TERF2IP,H2AFZ,SMC3,H2AFX,BRCA1,DIDO1,UBE2I,H2AFV,TERF1,POT1,LMNA,TERF2
R-HSA-3928663	EPHA-mediated growth cone collapse	0.681094055219822	-0.384054868977592	34	5	0.00294811320754717	1696	10287	4627,6093,387,4067,103910	MYH9,ROCK1,RHOA,LYN,MYL12B
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.681094055219822	-0.384054868977592	34	5	0.00294811320754717	1696	10287	10576,60,5204,5203,10694	CCT2,ACTB,PFDN5,PFDN4,CCT8
R-HSA-390466	Chaperonin-mediated protein folding	0.681747727786955	-0.383095590174417	99	15	0.00884433962264151	1696	10287	10576,5204,5203,2788,2629,26190,1457,60,8237,26224,2771,6774,2783,10694,83752	CCT2,PFDN5,PFDN4,GNG7,GBA,FBXW2,CSNK2A1,ACTB,USP11,FBXL3,GNAI2,STAT3,GNB2,CCT8,LONP2
R-HSA-8853659	RET signaling	0.687083389810276	-0.375299611578345	270	42	0.0247641509433962	1696	10287	4763,5894,8649,8315,5566,5715,805,2261,5708,5906,5707,5687,6464,5296,5781,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,409,5594,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PRKACA,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,PTPN11,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.688289565716579	-0.373545649192102	93	14	0.00825471698113208	1696	10287	3015,5441,2648,5440,10849,23451,3014,9031,60,84172,3020,30834,94239,221830	H2AFZ,POLR2L,KAT2A,POLR2K,CD3EAP,SF3B1,H2AFX,BAZ1B,ACTB,POLR1B,H3F3A,ZNRD1,H2AFV,TWISTNB
R-HSA-2299718	Condensation of Prophase Chromosomes	0.694535612069445	-0.364511840824555	74	11	0.00648584905660377	1696	10287	5347,5925,3015,387893,3014,10592,891,3020,94239,79648,10051	PLK1,RB1,H2AFZ,KMT5A,H2AFX,SMC2,CCNB1,H3F3A,H2AFV,MCPH1,SMC4
R-HSA-8849932	SALM protein interactions at the synapses	0.69709674292225	-0.360831078825688	21	3	0.0017688679245283	1696	10287	5792,10313,10211	PTPRF,RTN3,FLOT1
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.69709674292225	-0.360831078825688	21	3	0.0017688679245283	1696	10287	148022,351,1660	TICAM1,APP,DHX9
R-HSA-2028269	Signaling by Hippo	0.69709674292225	-0.360831078825688	21	3	0.0017688679245283	1696	10287	261734,55233,1856	NPHP4,MOB1A,DVL2
R-HSA-174403	Glutathione synthesis and recycling	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	2730,494143	GCLM,CHAC2
R-HSA-428540	Activation of Rac	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	4690,5879	NCK1,RAC1
R-HSA-2024101	CS/DS degradation	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	3073,3074	HEXA,HEXB
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	7159,332	TP53BP2,BIRC5
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	5164,8050	PDK2,PDHX
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.698058556660195	-0.35945228767519	14	2	0.00117924528301887	1696	10287	7159,208	TP53BP2,AKT2
R-HSA-354192	Integrin alphaIIb beta3 signaling	0.700936329219022	-0.355338224576241	28	4	0.00235849056603774	1696	10287	5170,5906,6464,1445	PDPK1,RAP1A,SHC1,CSK
R-HSA-1266695	Interleukin-7 signaling	0.700936329219022	-0.355338224576241	28	4	0.00235849056603774	1696	10287	6597,54014,3716,5296	SMARCA4,BRWD1,JAK1,PIK3R2
R-HSA-1368082	RORA activates gene expression	0.700936329219022	-0.355338224576241	28	4	0.00235849056603774	1696	10287	8648,10499,406,10498	NCOA1,NCOA2,ARNTL,CARM1
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.70627782052264	-0.347746605406863	55	8	0.00471698113207547	1696	10287	22937,9632,8648,9453,10654,10498,10499,2222	SCAP,SEC24C,NCOA1,GGPS1,PMVK,CARM1,NCOA2,FDFT1
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.711436620872279	-0.340468943603654	88	13	0.00766509433962264	1696	10287	7040,892,9612,112950,84246,51586,23389,8648,9967,7026,10499,6837,10498	TGFB1,CCNC,NCOR2,MED8,MED10,MED15,MED13L,NCOA1,THRAP3,NR2F2,NCOA2,MED22,CARM1
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.71276981524241	-0.338596750464035	42	6	0.0035377358490566	1696	10287	8648,10654,9453,10499,10498,2222	NCOA1,PMVK,GGPS1,NCOA2,CARM1,FDFT1
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	0.71276981524241	-0.338596750464035	42	6	0.0035377358490566	1696	10287	2778,5906,5566,2783,2788,5575	GNAS,RAP1A,PRKACA,GNB2,GNG7,PRKAR1B
R-HSA-1566948	Elastic fibre formation	0.71276981524241	-0.338596750464035	42	6	0.0035377358490566	1696	10287	7040,8425,3696,3693,4236,3688	TGFB1,LTBP4,ITGB8,ITGB5,MFAP1,ITGB1
R-HSA-73943	Reversal of alkylation damage by DNA dioxygenases	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	54890	ALKBH5
R-HSA-5652084	Fructose metabolism	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	231	AKR1B1
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	2030	SLC29A1
R-HSA-171319	Telomere Extension By Telomerase	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	10856	RUVBL2
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	8505	PARG
R-HSA-162791	Attachment of GPI anchor to uPAR	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	51604	PIGT
R-HSA-190371	FGFR3b ligand binding and activation	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	3516	RBPJ
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	5515	PPP2CA
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	80308	FLAD1
R-HSA-420597	Nectin/Necl  trans heterodimerization	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	23705	CADM1
R-HSA-426496	Post-transcriptional silencing by small RNAs	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	27161	AGO2
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.716789239903747	-0.332973428729083	7	1	0.000589622641509434	1696	10287	8313	AXIN2
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.727740692125361	-0.317810486372431	29	4	0.00235849056603774	1696	10287	7335,23118,351,1660	UBE2V1,TAB2,APP,DHX9
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.727740692125361	-0.317810486372431	29	4	0.00235849056603774	1696	10287	8648,28996,10499,10498	NCOA1,HIPK2,NCOA2,CARM1
R-HSA-196807	Nicotinate metabolism	0.727740692125361	-0.317810486372431	29	4	0.00235849056603774	1696	10287	128240,55191,84875,143	NAXE,NADSYN1,PARP10,PARP4
R-HSA-203765	eNOS activation and regulation	0.727809238033124	-0.317716300791581	22	3	0.0017688679245283	1696	10287	805,6697,1785	CALM2,SPR,DNM2
R-HSA-373753	Nephrin interactions	0.727809238033124	-0.317716300791581	22	3	0.0017688679245283	1696	10287	4690,5296,6709	NCK1,PIK3R2,SPTAN1
R-HSA-1482801	Acyl chain remodelling of PS	0.727809238033124	-0.317716300791581	22	3	0.0017688679245283	1696	10287	154141,114882,254531	MBOAT1,OSBPL8,LPCAT4
R-HSA-202131	Metabolism of nitric oxide	0.727809238033124	-0.317716300791581	22	3	0.0017688679245283	1696	10287	805,6697,1785	CALM2,SPR,DNM2
R-HSA-451927	Interleukin-2 signaling	0.729777244733839	-0.315015935605885	262	40	0.0235849056603774	1696	10287	4763,5894,8649,8315,5715,805,2261,5708,5906,5707,5687,6464,5296,818,6709,4893,9978,143471,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,6233,1445,5709,5714,84078,5536,5594,409,5700,3265	NF1,RAF1,LAMTOR3,BRAP,PSMD9,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,PIK3R2,CAMK2G,SPTAN1,NRAS,RBX1,PSMA8,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,RPS27A,CSK,PSMD3,PSMD8,KBTBD7,PPP5C,MAPK1,ARRB2,PSMC1,HRAS
R-HSA-445355	Smooth Muscle Contraction	0.730482676407134	-0.314049762778764	36	5	0.00294811320754717	1696	10287	805,309,3693,103910,140465	CALM2,ANXA6,ITGB5,MYL12B,MYL6B
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	0.734553505829505	-0.308492439418932	43	6	0.0035377358490566	1696	10287	1457,10576,2771,2783,10694,2788	CSNK2A1,CCT2,GNAI2,GNB2,CCT8,GNG7
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.734553505829505	-0.308492439418932	43	6	0.0035377358490566	1696	10287	7534,4221,6659,6233,208,331	YWHAZ,MEN1,SOX4,RPS27A,AKT2,XIAP
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.734656004365661	-0.308352910596649	15	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.734656004365661	-0.308352910596649	15	2	0.00117924528301887	1696	10287	387,51072	RHOA,MEMO1
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.741871059165501	-0.298579825624898	90	13	0.00766509433962264	1696	10287	5170,7409,2261,4193,7249,208,5296,5781,1027,84335,1385,2309,64223	PDPK1,VAV1,FGFR3,MDM2,TSC2,AKT2,PIK3R2,PTPN11,CDKN1B,AKT1S1,CREB1,FOXO3,MLST8
R-HSA-382551	Transmembrane transport of small molecules	0.741958957905729	-0.298461350140079	677	106	0.0625	1696	10287	55706,21,23511,118,1831,5894,89845,6513,81614,23456,2030,347734,526,5566,6574,51076,2783,805,533,5707,23225,5687,488,115,23446,57122,1185,6717,9972,1836,81929,10057,113,9550,1182,57130,143471,2788,9194,65010,5695,535,79751,9631,26503,5698,55974,476,6233,5714,5709,6400,527,6041,5700,8992,8086,10723,254428,8480,56172,53371,6522,5715,8766,7037,23165,1317,5708,8894,120,6509,92745,84912,10999,23545,215,6558,10559,9114,79902,53373,6048,818,4363,57185,2512,10613,133418,27032,57380,5575,5682,23,5691,5704,2778,79139,28231,51382,84061,6566,23636,528,9818,123606	NDC1,ABCA3,NUP188,ADD1,TSC22D3,RAF1,ABCC10,SLC2A1,NIPA2,ABCB10,SLC29A1,SLC35B2,ATP6V1B2,PRKACA,SLC20A1,CUTC,GNB2,CALM2,ATP6V0B,PSMD1,NUP210,PSMA6,ATP2A2,ADCY9,SLC44A1,NUP107,CLCN6,SRI,NUP153,SLC26A2,SEH1L,ABCC5,ADCY7,ATP6V1G1,CLCN3,ATP13A1,PSMA8,GNG7,SLC16A7,SLC26A6,PSMB7,ATP6V0A1,SLC25A22,NUP155,SLC17A5,PSMB9,SLC50A1,ATP1A1,RPS27A,PSMD8,PSMD3,SEL1L,ATP6V0C,RNASEL,PSMC1,ATP6V0E1,AAAS,SLC12A7,SLC41A1,RAE1,ANKH,NUP54,SLC4A2,PSMD9,RAB11A,TFRC,NUP205,SLC31A1,PSMD2,EIF2S2,ADD3,SLC1A4,SLC38A5,SLC35B4,SLC27A4,ATP6V0A2,ABCD1,SLC12A2,SLC35A1,ATP6V0D1,NUP85,TPCN1,RNF5,CAMK2G,ABCC1,NIPAL3,FTL,ERLIN1,EMB,ATP2C1,MRS2,PRKAR1B,PSMA1,ABCF1,PSMB3,PSMC4,GNAS,DERL1,SLCO4A1,ATP6V1D,MAGT1,SLC16A1,NUP62,ATP6V1C1,NUP58,NIPA1
R-HSA-5683826	Surfactant metabolism	0.752706493714108	-0.284079909751406	30	4	0.00235849056603774	1696	10287	51816,21,7270,29080	ADA2,ABCA3,TTF1,CCDC59
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.755136852799203	-0.280856284173382	44	6	0.0035377358490566	1696	10287	1455,221,23683,29095,171546,253782	CSNK1G2,ALDH3B1,PRKD3,ORMDL2,SPTSSA,CERS6
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	0.756021050904475	-0.279686058078533	23	3	0.0017688679245283	1696	10287	2771,2783,2788	GNAI2,GNB2,GNG7
R-HSA-73777	RNA Polymerase I Chain Elongation	0.756270988443422	-0.279355516708586	91	13	0.00766509433962264	1696	10287	7343,3015,5441,5440,10849,3014,84172,3020,30834,94239,2966,221830,11335	UBTF,H2AFZ,POLR2L,POLR2K,CD3EAP,H2AFX,POLR1B,H3F3A,ZNRD1,H2AFV,GTF2H2,TWISTNB,CBX3
R-HSA-171306	Packaging Of Telomere Ends	0.758293810064648	-0.276684356219486	51	7	0.00412735849056604	1696	10287	54386,3015,94239,25913,7013,7014,3014	TERF2IP,H2AFZ,H2AFV,POT1,TERF1,TERF2,H2AFX
R-HSA-936837	Ion transport by P-type ATPases	0.762031732133841	-0.271767080942282	58	8	0.00471698113207547	1696	10287	805,57130,476,488,51076,818,27032,6717	CALM2,ATP13A1,ATP1A1,ATP2A2,CUTC,CAMK2G,ATP2C1,SRI
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	351	APP
R-HSA-1253288	Downregulation of ERBB4 signaling	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	6233	RPS27A
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	8125	ANP32A
R-HSA-2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	191	AHCY
R-HSA-804914	Transport of fatty acids	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	10999	SLC27A4
R-HSA-5576890	Phase 3 - rapid repolarisation	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	3784	KCNQ1
R-HSA-8937144	Aryl hydrocarbon receptor signalling	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	10728	PTGES3
R-HSA-5358493	Synthesis of diphthamide-EEF2	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	120526	DNAJC24
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	2053	EPHX2
R-HSA-5362798	Release of Hh-Np from the secreting cell	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	6868	ADAM17
R-HSA-72731	Recycling of eIF2:GDP	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	8894	EIF2S2
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	6794	STK11
R-HSA-73942	DNA Damage Reversal	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	54890	ALKBH5
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	3693	ITGB5
R-HSA-2142789	Ubiquinol biosynthesis	0.76351350536044	-0.269824465730136	8	1	0.000589622641509434	1696	10287	57107	PDSS2
R-HSA-391251	Protein folding	0.767274910874818	-0.264910118267659	105	15	0.00884433962264151	1696	10287	10576,5204,5203,2788,2629,26190,1457,60,8237,26224,2771,6774,2783,10694,83752	CCT2,PFDN5,PFDN4,GNG7,GBA,FBXW2,CSNK2A1,ACTB,USP11,FBXL3,GNAI2,STAT3,GNB2,CCT8,LONP2
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.767401008777759	-0.264745786630458	16	2	0.00117924528301887	1696	10287	8454,6233	CUL1,RPS27A
R-HSA-1433559	Regulation of KIT signaling	0.767401008777759	-0.264745786630458	16	2	0.00117924528301887	1696	10287	4067,9306	LYN,SOCS6
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.767401008777759	-0.264745786630458	16	2	0.00117924528301887	1696	10287	29028,7528	ATAD2,YY1
R-HSA-446353	Cell-extracellular matrix interactions	0.767401008777759	-0.264745786630458	16	2	0.00117924528301887	1696	10287	7408,3688	VASP,ITGB1
R-HSA-159418	Recycling of bile acids and salts	0.767401008777759	-0.264745786630458	16	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.774527636573977	-0.255501936645021	45	6	0.0035377358490566	1696	10287	124446,7159,147923,839,332,355	TMEM219,TP53BP2,ZNF420,CASP6,BIRC5,FAS
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	0.775870304944203	-0.253769905571024	31	4	0.00235849056603774	1696	10287	2746,5832,4942,2806	GLUD1,ALDH18A1,OAT,GOT2
R-HSA-3214842	HDMs demethylate histones	0.77628215635932	-0.253239221330848	52	7	0.00412735849056604	1696	10287	51780,23210,22992,221656,9682,55818,84864	KDM3B,JMJD6,KDM2A,KDM1B,KDM4A,KDM3A,RIOX2
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.793648145734946	-0.23111505734292	127	18	0.0106132075471698	1696	10287	892,9612,23389,9967,4899,84246,112950,51,51586,406,8648,23179,34,19,10499,10498,6837,2222	CCNC,NCOR2,MED13L,THRAP3,NRF1,MED10,MED8,ACOX1,MED15,ARNTL,NCOA1,RGL1,ACADM,ABCA1,NCOA2,CARM1,MED22,FDFT1
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.796164638441527	-0.227949282311614	94	13	0.00766509433962264	1696	10287	5515,7409,2261,5525,5728,208,5296,5781,79837,5594,5305,5595,23396	PPP2CA,VAV1,FGFR3,PPP2R5A,PTEN,AKT2,PIK3R2,PTPN11,PIP4K2C,MAPK1,PIP4K2A,MAPK3,PIP5K1C
R-HSA-3214815	HDACs deacetylate histones	0.796164638441527	-0.227949282311614	94	13	0.00766509433962264	1696	10287	25855,9612,1107,2874,9112,9219,23186,5928,53615,79685,5926,3066,8819	BRMS1,NCOR2,CHD3,GPS2,MTA1,MTA2,RCOR1,RBBP4,MBD3,SAP30L,ARID4A,HDAC2,SAP30
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	0.796568324196111	-0.227442372775994	17	2	0.00117924528301887	1696	10287	79717,60490	PPCS,PPCDC
R-HSA-139853	Elevation of cytosolic Ca2+ levels	0.796568324196111	-0.227442372775994	17	2	0.00117924528301887	1696	10287	84876,80228	ORAI1,ORAI2
R-HSA-166665	Terminal pathway of complement	0.802532971761835	-0.219982338514403	9	1	0.000589622641509434	1696	10287	1191	CLU
R-HSA-428890	Role of Abl in Robo-Slit signaling	0.802532971761835	-0.219982338514403	9	1	0.000589622641509434	1696	10287	27	ABL2
R-HSA-390696	Adrenoceptors	0.802532971761835	-0.219982338514403	9	1	0.000589622641509434	1696	10287	154	ADRB2
R-HSA-1614558	Degradation of cysteine and homocysteine	0.802532971761835	-0.219982338514403	9	1	0.000589622641509434	1696	10287	84890	ADO
R-HSA-447041	CHL1 interactions	0.802532971761835	-0.219982338514403	9	1	0.000589622641509434	1696	10287	3688	ITGB1
R-HSA-196854	Metabolism of vitamins and cofactors	0.804348037074138	-0.217723221536517	174	25	0.0147405660377358	1696	10287	55191,25974,79717,4594,375790,6513,143,56922,6383,79001,4548,51293,1528,51109,80308,6573,10797,60490,60386,128240,200895,8566,84875,7804,4363	NADSYN1,MMACHC,PPCS,MUT,AGRN,SLC2A1,PARP4,MCCC1,SDC2,VKORC1,MTR,CD320,CYB5A,RDH11,FLAD1,SLC19A1,MTHFD2,PPCDC,SLC25A19,NAXE,DHFR2,PDXK,PARP10,LRP8,ABCC1
R-HSA-912446	Meiotic recombination	0.805235533594159	-0.216620456043462	88	12	0.00707547169811321	1696	10287	6118,5889,84057,3015,3014,7156,672,641,3020,1017,94239,6117	RPA2,RAD51C,MND1,H2AFZ,H2AFX,TOP3A,BRCA1,BLM,H3F3A,CDK2,H2AFV,RPA1
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	0.805327526003711	-0.216506219709649	25	3	0.0017688679245283	1696	10287	1432,2783,2788	MAPK14,GNB2,GNG7
R-HSA-4086398	Ca2+ pathway	0.809791063286695	-0.210979011149225	61	8	0.00471698113207547	1696	10287	805,5530,2788,27161,5534,5532,2783,8323	CALM2,PPP3CA,GNG7,AGO2,PPP3R1,PPP3CB,GNB2,FZD6
R-HSA-977444	GABA B receptor activation	0.812054315659747	-0.208188049850991	40	5	0.00294811320754717	1696	10287	2771,2783,2788,115,113	GNAI2,GNB2,GNG7,ADCY9,ADCY7
R-HSA-991365	Activation of GABAB receptors	0.812054315659747	-0.208188049850991	40	5	0.00294811320754717	1696	10287	2771,2783,2788,115,113	GNAI2,GNB2,GNG7,ADCY9,ADCY7
R-HSA-392518	Signal amplification	0.817016270680931	-0.2020962691663	33	4	0.00235849056603774	1696	10287	2771,1432,2783,2788	GNAI2,MAPK14,GNB2,GNG7
R-HSA-5654710	PI-3K cascade:FGFR3	0.822446861477685	-0.195471404535833	18	2	0.00117924528301887	1696	10287	2261,5781	FGFR3,PTPN11
R-HSA-1482925	Acyl chain remodelling of PG	0.822446861477685	-0.195471404535833	18	2	0.00117924528301887	1696	10287	79888,254531	LPCAT1,LPCAT4
R-HSA-1369062	ABC transporters in lipid homeostasis	0.822446861477685	-0.195471404535833	18	2	0.00117924528301887	1696	10287	215,21	ABCD1,ABCA3
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.82452510796885	-0.192947685088536	69	9	0.00530660377358491	1696	10287	55775,9577,5591,29086,3014,64421,672,7518,7520	TDP1,BABAM2,PRKDC,BABAM1,H2AFX,DCLRE1C,BRCA1,XRCC4,XRCC5
R-HSA-418597	G alpha (z) signalling events	0.825750526383496	-0.19146257725035	48	6	0.0035377358490566	1696	10287	2778,2771,2783,2788,115,113	GNAS,GNAI2,GNB2,GNG7,ADCY9,ADCY7
R-HSA-556833	Metabolism of lipids and lipoproteins	0.825971921027137	-0.191194499952843	813	125	0.0737028301886792	1696	10287	892,51552,29801,3074,10554,56910,1457,1120,10423,5566,9453,80230,253558,8895,390916,1666,4899,23683,25816,9110,5296,9663,23446,5867,3032,231,163,9524,171546,23171,2760,10498,2879,51703,8904,5538,9107,25870,23760,23344,6901,51099,5445,221,58526,10555,22937,253782,406,23417,79777,154141,949,8648,4048,56994,1175,19,83930,9612,8760,4594,64781,23389,427,56894,285362,9967,375,2053,10654,5305,23396,1119,10682,112950,84246,5728,9632,1384,622,215,51228,5833,10728,200576,79888,10499,6837,6576,4363,2222,1455,60481,2581,65985,9489,50814,2181,2629,79837,50640,153642,4758,55361,8897,23646,29095,114882,51,51586,1622,47,254531,38,5476,34,55627,23179,5660,3073,9791,57107,80221,57488	CCNC,RAB14,ZDHHC8,HEXB,AGPAT1,STARD7,CSNK2A1,CHKB,CDIPT,PRKACA,GGPS1,RUFY1,LCLAT1,CPNE3,NUDT19,DECR1,NRF1,PRKD3,TNFAIP8,MTMR4,PIK3R2,LPIN2,SLC44A1,RAB4A,HADHB,AKR1B1,AP2B1,TECR,SPTSSA,GPD1L,GM2A,CARM1,GPX4,ACSL5,CPNE1,PPT1,MTMR6,SUMF2,PITPNB,ESYT1,TAZ,ABHD5,PON2,ALDH3B1,MID1IP1,AGPAT2,SCAP,CERS6,ARNTL,MLYCD,ACBD4,MBOAT1,SCARB1,NCOA1,LTA4H,CHPT1,AP2S1,ABCA1,STARD3NL,NCOR2,CDS2,MUT,CERK,MED13L,ASAH1,AGPAT3,SUMF1,THRAP3,ARF1,EPHX2,PMVK,PIP4K2A,PIP5K1C,CHKA,EBP,MED8,MED10,PTEN,SEC24C,CRAT,BDH1,ABCD1,GLTP,PCYT2,PTGES3,PIKFYVE,LPCAT1,NCOA2,MED22,SLC25A1,ABCC1,FDFT1,CSNK1G2,ELOVL5,GALC,AACS,PGS1,NSDHL,ACSL3,GBA,PIP4K2C,PNPLA8,ARSK,NEU1,PI4K2A,MTMR3,PLD3,ORMDL2,OSBPL8,ACOX1,MED15,DBI,ACLY,LPCAT4,ACAT1,CTSA,ACADM,SMPD4,RGL1,PSAP,HEXA,PTDSS1,PDSS2,ACSF2,ESYT2
R-HSA-912694	Regulation of IFNA signaling	0.826660909790825	-0.190360692478179	26	3	0.0017688679245283	1696	10287	3716,6772,5781	JAK1,STAT1,PTPN11
R-HSA-1971475	A tetrasaccharide linker sequence is required for GAG synthesis	0.826660909790825	-0.190360692478179	26	3	0.0017688679245283	1696	10287	126792,375790,6383	B3GALT6,AGRN,SDC2
R-HSA-210991	Basigin interactions	0.826660909790825	-0.190360692478179	26	3	0.0017688679245283	1696	10287	6566,23759,3688	SLC16A1,PPIL2,ITGB1
R-HSA-1989781	PPARA activates gene expression	0.831196256967367	-0.184889342374526	124	17	0.0100235849056604	1696	10287	892,23389,9967,4899,84246,112950,51,51586,406,8648,23179,34,19,10498,6837,10499,2222	CCNC,MED13L,THRAP3,NRF1,MED10,MED8,ACOX1,MED15,ARNTL,NCOA1,RGL1,ACADM,ABCA1,CARM1,MED22,NCOA2,FDFT1
R-HSA-74259	Purine catabolism	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	847	CAT
R-HSA-425381	Bicarbonate transporters	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	6522	SLC4A2
R-HSA-418886	Netrin mediated repulsion signals	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-8866904	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	7329	UBE2I
R-HSA-2161522	Abacavir transport and metabolism	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	2987	GUK1
R-HSA-418890	Role of second messengers in netrin-1 signaling	0.835117529056636	-0.180182810674866	10	1	0.000589622641509434	1696	10287	5306	PITPNA
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	0.845327560256282	-0.168031081466274	19	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.845327560256282	-0.168031081466274	19	2	0.00117924528301887	1696	10287	7335,23118	UBE2V1,TAB2
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	0.845327560256282	-0.168031081466274	19	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	0.845327560256282	-0.168031081466274	19	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	0.845327560256282	-0.168031081466274	19	2	0.00117924528301887	1696	10287	23478,60559	SEC11A,SPCS3
R-HSA-1482788	Acyl chain remodelling of PC	0.845958879617407	-0.16728452621039	27	3	0.0017688679245283	1696	10287	50640,79888,254531	PNPLA8,LPCAT1,LPCAT4
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	0.851735863952788	-0.160478819053351	35	4	0.00235849056603774	1696	10287	805,2339,9397,79823	CALM2,FNTA,NMT2,CAMKMT
R-HSA-5362517	Signaling by Retinoic Acid	0.859246472321719	-0.151699468792516	43	5	0.00294811320754717	1696	10287	5164,8050,157506,6257,51109	PDK2,PDHX,RDH10,RXRB,RDH11
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.860458826252388	-0.150289513107065	72	9	0.00530660377358491	1696	10287	11339,3015,55355,3014,79019,80152,5928,94239,79682	OIP5,H2AFZ,HJURP,H2AFX,CENPM,CENPT,RBBP4,H2AFV,CENPU
R-HSA-774815	Nucleosome assembly	0.860458826252388	-0.150289513107065	72	9	0.00530660377358491	1696	10287	11339,3015,55355,3014,79019,80152,5928,94239,79682	OIP5,H2AFZ,HJURP,H2AFX,CENPM,CENPT,RBBP4,H2AFV,CENPU
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	7335	UBE2V1
R-HSA-196780	Biotin transport and metabolism	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	56922	MCCC1
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	22926	ATF6
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	10721	POLQ
R-HSA-937039	IRAK1 recruits IKK complex	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	7335	UBE2V1
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	0.862327869692498	-0.148119721364655	11	1	0.000589622641509434	1696	10287	58526	MID1IP1
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.863361585660318	-0.146921688789034	28	3	0.0017688679245283	1696	10287	2771,2783,2788	GNAI2,GNB2,GNG7
R-HSA-163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.865494871427445	-0.144453829943863	20	2	0.00117924528301887	1696	10287	5566,51099	PRKACA,ABHD5
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.865494871427445	-0.144453829943863	20	2	0.00117924528301887	1696	10287	23478,60559	SEC11A,SPCS3
R-HSA-418217	G beta:gamma signalling through PLC beta	0.865494871427445	-0.144453829943863	20	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-6788467	IL-6-type cytokine receptor ligand interactions	0.865494871427445	-0.144453829943863	20	2	0.00117924528301887	1696	10287	3716,3572	JAK1,IL6ST
R-HSA-2514856	The phototransduction cascade	0.866892512399417	-0.142840286358574	36	4	0.00235849056603774	1696	10287	805,2339,9397,79823	CALM2,FNTA,NMT2,CAMKMT
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	0.867245711089067	-0.142432938559246	51	6	0.0035377358490566	1696	10287	126792,375790,3073,54480,3074,6383	B3GALT6,AGRN,HEXA,CHPF2,HEXB,SDC2
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.869872523765883	-0.139408602476288	87	11	0.00648584905660377	1696	10287	5515,7409,2261,5525,5296,5781,79837,5594,5305,5595,23396	PPP2CA,VAV1,FGFR3,PPP2R5A,PIK3R2,PTPN11,PIP4K2C,MAPK1,PIP4K2A,MAPK3,PIP5K1C
R-HSA-422356	Regulation of insulin secretion	0.870173757303477	-0.13906236623662	80	10	0.00589622641509434	1696	10287	2778,5906,2788,6513,5575,10768,5566,292,2771,2783	GNAS,RAP1A,GNG7,SLC2A1,PRKAR1B,AHCYL1,PRKACA,SLC25A5,GNAI2,GNB2
R-HSA-1482839	Acyl chain remodelling of PE	0.879010150285986	-0.128958833825536	29	3	0.0017688679245283	1696	10287	154141,50640,254531	MBOAT1,PNPLA8,LPCAT4
R-HSA-202040	G-protein activation	0.879010150285986	-0.128958833825536	29	3	0.0017688679245283	1696	10287	2771,2783,2788	GNAI2,GNB2,GNG7
R-HSA-419037	NCAM1 interactions	0.880697897661276	-0.127040620296003	37	4	0.00235849056603774	1696	10287	782,375790,8128,5621	CACNB1,AGRN,ST8SIA2,PRNP
R-HSA-500657	Presynaptic function of Kainate receptors	0.883220990209954	-0.124179837652546	21	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.883220990209954	-0.124179837652546	21	2	0.00117924528301887	1696	10287	7159,147923	TP53BP2,ZNF420
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.884852137296435	-0.122334724434244	45	5	0.00294811320754717	1696	10287	7040,375790,3693,3688,6383	TGFB1,AGRN,ITGB5,ITGB1,SDC2
R-HSA-879518	Transport of organic anions	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	28231	SLCO4A1
R-HSA-203615	eNOS activation	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	805	CALM2
R-HSA-1839130	Signaling by activated point mutants of FGFR3	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-8851680	Butyrophilin (BTN) family interactions	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	11119	BTN3A1
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	805	CALM2
R-HSA-451306	Ionotropic activity of Kainate Receptors	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	805	CALM2
R-HSA-5578768	Physiological factors	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	28996	HIPK2
R-HSA-71064	Lysine catabolism	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	4967	OGDH
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	7335	UBE2V1
R-HSA-2033514	FGFR3 mutant receptor activation	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	10370	CITED2
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.885049934026147	-0.12211121293749	12	1	0.000589622641509434	1696	10287	839	CASP6
R-HSA-420092	Glucagon-type ligand receptors	0.893043889907326	-0.11311955048101	30	3	0.0017688679245283	1696	10287	2778,2783,2788	GNAS,GNB2,GNG7
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.893241427160834	-0.112898379481702	38	4	0.00235849056603774	1696	10287	5170,5906,6464,1445	PDPK1,RAP1A,SHC1,CSK
R-HSA-446652	Interleukin-1 signaling	0.896084994889667	-0.109720010138235	46	5	0.00294811320754717	1696	10287	8454,7335,23118,54472,6233	CUL1,UBE2V1,TAB2,TOLLIP,RPS27A
R-HSA-425407	SLC-mediated transmembrane transport	0.898442583288962	-0.107092477650746	287	40	0.0235849056603774	1696	10287	10723,55706,23511,254428,8480,6513,53371,6522,2030,347734,6574,23165,805,1317,23225,6509,92745,23446,84912,57122,6717,10999,9972,1836,6558,10559,79902,81929,133418,9194,65010,79751,9631,26503,55974,28231,6566,23636,9818,8086	SLC12A7,NDC1,NUP188,SLC41A1,RAE1,SLC2A1,NUP54,SLC4A2,SLC29A1,SLC35B2,SLC20A1,NUP205,CALM2,SLC31A1,NUP210,SLC1A4,SLC38A5,SLC44A1,SLC35B4,NUP107,SRI,SLC27A4,NUP153,SLC26A2,SLC12A2,SLC35A1,NUP85,SEH1L,EMB,SLC16A7,SLC26A6,SLC25A22,NUP155,SLC17A5,SLC50A1,SLCO4A1,SLC16A1,NUP62,NUP58,AAAS
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.898762165416767	-0.106736834108847	22	2	0.00117924528301887	1696	10287	4048,4363	LTA4H,ABCC1
R-HSA-1638091	Heparan sulfate/heparin (HS-GAG) metabolism	0.900172800300798	-0.105168533753311	54	6	0.0035377358490566	1696	10287	126792,6448,375790,2132,4669,6383	B3GALT6,SGSH,AGRN,EXT2,NAGLU,SDC2
R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	10370	CITED2
R-HSA-2029481	FCGR activation	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	4067	LYN
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	782	CACNB1
R-HSA-2168880	Scavenging of heme from plasma	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	8542	APOL1
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	6774	STAT3
R-HSA-190239	FGFR3 ligand binding and activation	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	22926	ATF6
R-HSA-391160	Signal regulatory protein (SIRP) family interactions	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	5879	RAC1
R-HSA-190372	FGFR3c ligand binding and activation	0.904023686993761	-0.100899716506511	13	1	0.000589622641509434	1696	10287	2261	FGFR3
R-HSA-5339562	Uptake and actions of bacterial toxins	0.905598202585974	-0.0991595563121606	31	3	0.0017688679245283	1696	10287	805,10015,5605	CALM2,PDCD6IP,MAP2K2
R-HSA-2022928	HS-GAG biosynthesis	0.905598202585974	-0.0991595563121606	31	3	0.0017688679245283	1696	10287	375790,2132,6383	AGRN,EXT2,SDC2
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	23478,60559	SEC11A,SPCS3
R-HSA-389948	PD-1 signaling	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	1445,5781	CSK,PTPN11
R-HSA-428930	Thromboxane signalling through TP receptor	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	157506,51109	RDH10,RDH11
R-HSA-8855121	VLDL interactions	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	163,1175	AP2B1,AP2S1
R-HSA-5365859	RA biosynthesis pathway	0.912356557289163	-0.0917244033736391	23	2	0.00117924528301887	1696	10287	157506,51109	RDH10,RDH11
R-HSA-73728	RNA Polymerase I Promoter Opening	0.91326017865808	-0.0907344678357826	63	7	0.00412735849056604	1696	10287	7343,3015,3020,94239,8932,5595,3014	UBTF,H2AFZ,H3F3A,H2AFV,MBD2,MAPK3,H2AFX
R-HSA-1442490	Collagen degradation	0.914895983542136	-0.0889448993575064	40	4	0.00235849056603774	1696	10287	1514,8754,6868,102	CTSL,ADAM9,ADAM17,ADAM10
R-HSA-451326	Activation of Kainate Receptors upon glutamate binding	0.916803014453671	-0.086862645010411	32	3	0.0017688679245283	1696	10287	805,2783,2788	CALM2,GNB2,GNG7
R-HSA-209560	NF-kB is activated and signals survival	0.919867158558261	-0.0835260122361612	14	1	0.000589622641509434	1696	10287	6233	RPS27A
R-HSA-428790	Facilitative Na+-independent glucose transporters	0.919867158558261	-0.0835260122361612	14	1	0.000589622641509434	1696	10287	6513	SLC2A1
R-HSA-209543	p75NTR recruits signalling complexes	0.919867158558261	-0.0835260122361612	14	1	0.000589622641509434	1696	10287	6233	RPS27A
R-HSA-419408	Lysosphingolipid and LPA receptors	0.919867158558261	-0.0835260122361612	14	1	0.000589622641509434	1696	10287	9294	S1PR2
R-HSA-171052	LDL-mediated lipid transport	0.924223234194243	-0.0788016410716182	24	2	0.00117924528301887	1696	10287	163,1175	AP2B1,AP2S1
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.924223234194243	-0.0788016410716182	24	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	0.924223234194243	-0.0788016410716182	24	2	0.00117924528301887	1696	10287	5140,2983	PDE3B,GUCY1B1
R-HSA-202433	Generation of second messenger molecules	0.926781688845499	-0.0760372440149753	33	3	0.0017688679245283	1696	10287	7408,7454,4690	VASP,WAS,NCK1
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.933096526724605	-0.0692466250461571	15	1	0.000589622641509434	1696	10287	10728	PTGES3
R-HSA-5682910	LGI-ADAM interactions	0.933096526724605	-0.0692466250461571	15	1	0.000589622641509434	1696	10287	8745	ADAM23
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	0.933096526724605	-0.0692466250461571	15	1	0.000589622641509434	1696	10287	4041	LRP5
R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.934537322142162	-0.0677037147971729	146	18	0.0106132075471698	1696	10287	5170,6195,5894,2788,5566,2783,805,4193,4905,115,163,1385,5594,2771,3265,1175,818,113	PDPK1,RPS6KA1,RAF1,GNG7,PRKACA,GNB2,CALM2,MDM2,NSF,ADCY9,AP2B1,CREB1,MAPK1,GNAI2,HRAS,AP2S1,CAMK2G,ADCY7
R-HSA-997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.934561991430846	-0.0676773178170807	25	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-1296059	G protein gated Potassium channels	0.934561991430846	-0.0676773178170807	25	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-425410	Metal ion SLC transporters	0.934561991430846	-0.0676773178170807	25	2	0.00117924528301887	1696	10287	1317,254428	SLC31A1,SLC41A1
R-HSA-1296041	Activation of G protein gated Potassium channels	0.934561991430846	-0.0676773178170807	25	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-212300	PRC2 methylates histones and DNA	0.937123869005375	-0.0649398080366567	74	8	0.00471698113207547	1696	10287	1788,3015,23512,3014,5928,3020,94239,1786	DNMT3A,H2AFZ,SUZ12,H2AFX,RBBP4,H3F3A,H2AFV,DNMT1
R-HSA-6785807	Interleukin-4 and 13 signaling	0.93751966215709	-0.0645175483899376	111	13	0.00766509433962264	1696	10287	7040,3662,3716,332,6778,6772,3688,596,4170,598,6774,2309,9655	TGFB1,IRF4,JAK1,BIRC5,STAT6,STAT1,ITGB1,BCL2,MCL1,BCL2L1,STAT3,FOXO3,SOCS5
R-HSA-2142753	Arachidonic acid metabolism	0.939528233418377	-0.0623774090438309	59	6	0.0035377358490566	1696	10287	5445,10728,2053,4048,4363,2879	PON2,PTGES3,EPHX2,LTA4H,ABCC1,GPX4
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.940056539485487	-0.0618152571381137	43	4	0.00235849056603774	1696	10287	2512,10808,949,8542	FTL,HSPH1,SCARB1,APOL1
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	0.943553748234292	-0.058101948934087	26	2	0.00117924528301887	1696	10287	375790,6383	AGRN,SDC2
R-HSA-1474165	Reproduction	0.943553748234292	-0.058101948934087	26	2	0.00117924528301887	1696	10287	2683,7784	B4GALT1,ZP3
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.943553748234292	-0.058101948934087	26	2	0.00117924528301887	1696	10287	81029,51699	WNT5B,VPS29
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	0.943553748234292	-0.058101948934087	26	2	0.00117924528301887	1696	10287	10576,10694	CCT2,CCT8
R-HSA-1187000	Fertilization	0.943553748234292	-0.058101948934087	26	2	0.00117924528301887	1696	10287	2683,7784	B4GALT1,ZP3
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.944142894577629	-0.0574777529175198	16	1	0.000589622641509434	1696	10287	5906	RAP1A
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.944142894577629	-0.0574777529175198	16	1	0.000589622641509434	1696	10287	5906	RAP1A
R-HSA-975634	Retinoid metabolism and transport	0.946802807491497	-0.0546644361043126	44	4	0.00235849056603774	1696	10287	375790,7804,6383,51109	AGRN,LRP8,SDC2,RDH11
R-HSA-6806667	Metabolism of fat-soluble vitamins	0.951212464229547	-0.0500178300018179	53	5	0.00294811320754717	1696	10287	79001,375790,7804,6383,51109	VKORC1,AGRN,LRP8,SDC2,RDH11
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	0.952049079860013	-0.0491386910448545	107	12	0.00707547169811321	1696	10287	10723,805,6509,92745,65010,6717,79751,6522,26503,1836,6574,6558	SLC12A7,CALM2,SLC1A4,SLC38A5,SLC26A6,SRI,SLC25A22,SLC4A2,SLC17A5,SLC26A2,SLC20A1,SLC12A2
R-HSA-193639	p75NTR signals via NF-kB	0.953366305257715	-0.0477560784997616	17	1	0.000589622641509434	1696	10287	6233	RPS27A
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	0.953366305257715	-0.0477560784997616	17	1	0.000589622641509434	1696	10287	818	CAMK2G
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.953366305257715	-0.0477560784997616	17	1	0.000589622641509434	1696	10287	8541	PPFIA3
R-HSA-5576893	Phase 2 - plateau phase	0.958130549423966	-0.0427712374104407	28	2	0.00117924528301887	1696	10287	782,3784	CACNB1,KCNQ1
R-HSA-190828	Gap junction trafficking	0.958130549423966	-0.0427712374104407	28	2	0.00117924528301887	1696	10287	1212,1785	CLTB,DNM2
R-HSA-211976	Endogenous sterols	0.958130549423966	-0.0427712374104407	28	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.958130549423966	-0.0427712374104407	28	2	0.00117924528301887	1696	10287	805,5728	CALM2,PTEN
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.961067449002076	-0.0397106862083171	18	1	0.000589622641509434	1696	10287	8541	PPFIA3
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.961067449002076	-0.0397106862083171	18	1	0.000589622641509434	1696	10287	8541	PPFIA3
R-HSA-418457	cGMP effects	0.961067449002076	-0.0397106862083171	18	1	0.000589622641509434	1696	10287	5140	PDE3B
R-HSA-156590	Glutathione conjugation	0.962074931625816	-0.0386629398468891	38	3	0.0017688679245283	1696	10287	373156,2730,494143	GSTK1,GCLM,CHAC2
R-HSA-6794362	Protein-protein interactions at synapses	0.964251586805417	-0.0364030362582162	72	7	0.00412735849056604	1696	10287	5792,9456,10611,10313,2035,22839,10211	PTPRF,HOMER1,PDLIM5,RTN3,EPB41,DLGAP4,FLOT1
R-HSA-977443	GABA receptor activation	0.965342592720961	-0.0352722222835689	56	5	0.00294811320754717	1696	10287	2771,2783,2788,115,113	GNAI2,GNB2,GNG7,ADCY9,ADCY7
R-HSA-3928664	Ephrin signaling	0.967497442810941	-0.0330424971711597	19	1	0.000589622641509434	1696	10287	5879	RAC1
R-HSA-888590	GABA synthesis, release, reuptake and degradation	0.967497442810941	-0.0330424971711597	19	1	0.000589622641509434	1696	10287	80331	DNAJC5
R-HSA-913709	O-linked glycosylation of mucins	0.968098346282264	-0.032421599467193	65	6	0.0035377358490566	1696	10287	6483,56913,55568,51809,2590,9334	ST3GAL2,C1GALT1,GALNT10,GALNT7,GALNT2,B4GALT5
R-HSA-5334118	DNA methylation	0.968098346282264	-0.032421599467193	65	6	0.0035377358490566	1696	10287	1788,3015,3020,94239,1786,3014	DNMT3A,H2AFZ,H3F3A,H2AFV,DNMT1,H2AFX
R-HSA-157858	Gap junction trafficking and regulation	0.969058993275815	-0.0314297883709211	30	2	0.00117924528301887	1696	10287	1212,1785	CLTB,DNM2
R-HSA-445095	Interaction between L1 and Ankyrins	0.969058993275815	-0.0314297883709211	30	2	0.00117924528301887	1696	10287	288,6709	ANK3,SPTAN1
R-HSA-1280215	Cytokine Signaling in Immune system	0.969439651537468	-0.0310370532327624	756	107	0.0630896226415094	1696	10287	55706,23511,4763,5894,8454,6597,3661,598,5566,4067,329,1399,805,7409,5906,5707,23225,5687,6464,6672,9775,5300,3572,5296,200081,57122,9972,9830,81929,81603,4893,330,143471,9978,5695,8452,4170,9631,7335,3594,54472,5698,5515,5525,54014,3716,23118,6233,5714,6778,5709,6772,3688,3838,6041,5536,409,5594,5700,8086,23586,3133,8480,8649,53371,8315,51447,5715,2309,3105,23165,5771,3662,5708,2261,5781,596,9020,6774,79902,9040,818,6709,9655,7040,6868,5682,3845,1982,5605,5691,9636,3663,5595,5704,3106,3840,3836,7726,332,1445,84078,5371,23636,7534,3265,9818	NDC1,NUP188,NF1,RAF1,CUL1,SMARCA4,IRF3,BCL2L1,PRKACA,LYN,BIRC2,CRKL,CALM2,VAV1,RAP1A,PSMD1,NUP210,PSMA6,SHC1,SP100,EIF4A3,PIN1,IL6ST,PIK3R2,TXLNA,NUP107,NUP153,TRIM14,SEH1L,TRIM8,NRAS,BIRC3,PSMA8,RBX1,PSMB7,CUL3,MCL1,NUP155,UBE2V1,IL12RB1,TOLLIP,PSMB9,PPP2CA,PPP2R5A,BRWD1,JAK1,TAB2,RPS27A,PSMD8,STAT6,PSMD3,STAT1,ITGB1,KPNA2,RNASEL,PPP5C,ARRB2,MAPK1,PSMC1,AAAS,DDX58,HLA-E,RAE1,LAMTOR3,NUP54,BRAP,IP6K2,PSMD9,FOXO3,HLA-A,NUP205,PTPN2,IRF4,PSMD2,FGFR3,PTPN11,BCL2,MAP3K14,STAT3,NUP85,UBE2M,CAMK2G,SPTAN1,SOCS5,TGFB1,ADAM17,PSMA1,KRAS,EIF4G2,MAP2K2,PSMB3,ISG15,IRF5,MAPK3,PSMC4,HLA-B,KPNA4,KPNA1,TRIM26,BIRC5,CSK,KBTBD7,PML,NUP62,YWHAZ,HRAS,NUP58
R-HSA-202733	Cell surface interactions at the vascular wall	0.972444156130133	-0.0279426281407333	136	15	0.00884433962264151	1696	10287	4282,7040,4893,6464,6404,23759,5296,3688,5781,6383,2734,6566,3845,4067,3265	MIF,TGFB1,NRAS,SHC1,SELPLG,PPIL2,PIK3R2,ITGB1,PTPN11,SDC2,GLG1,SLC16A1,KRAS,LYN,HRAS
R-HSA-156580	Phase II conjugation	0.972739979645407	-0.0276384682289659	106	11	0.00648584905660377	1696	10287	27430,373156,2730,7360,84836,191,1836,347734,494143,4548,4144	MAT2B,GSTK1,GCLM,UGP2,ABHD14B,AHCY,SLC26A2,SLC35B2,CHAC2,MTR,MAT2A
R-HSA-8874081	MET activates PTK2 signaling	0.972865999219727	-0.0275089254789279	20	1	0.000589622641509434	1696	10287	3688	ITGB1
R-HSA-5654720	PI-3K cascade:FGFR4	0.972865999219727	-0.0275089254789279	20	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-1296065	Inwardly rectifying K+ channels	0.97343559953417	-0.0269236098926188	31	2	0.00117924528301887	1696	10287	2783,2788	GNB2,GNG7
R-HSA-352230	Amino acid transport across the plasma membrane	0.97343559953417	-0.0269236098926188	31	2	0.00117924528301887	1696	10287	6509,92745	SLC1A4,SLC38A5
R-HSA-418990	Adherens junctions interactions	0.97343559953417	-0.0269236098926188	31	2	0.00117924528301887	1696	10287	4301,23705	AFDN,CADM1
R-HSA-196071	Metabolism of steroid hormones	0.977211105215276	-0.0230525753413118	32	2	0.00117924528301887	1696	10287	231,83930	AKR1B1,STARD3NL
R-HSA-3000480	Scavenging by Class A Receptors	0.97734824966353	-0.0229122424850735	21	1	0.000589622641509434	1696	10287	2512	FTL
R-HSA-2022870	Chondroitin sulfate biosynthesis	0.97734824966353	-0.0229122424850735	21	1	0.000589622641509434	1696	10287	54480	CHPF2
R-HSA-5654689	PI-3K cascade:FGFR1	0.97734824966353	-0.0229122424850735	21	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-210745	Regulation of gene expression in beta cells	0.97734824966353	-0.0229122424850735	21	1	0.000589622641509434	1696	10287	208	AKT2
R-HSA-186712	Regulation of beta-cell development	0.9804646159648	-0.0197287217431667	33	2	0.00117924528301887	1696	10287	3516,208	RBPJ,AKT2
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	0.981090444138664	-0.0190906278065468	22	1	0.000589622641509434	1696	10287	1445	CSK
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.981090444138664	-0.0190906278065468	22	1	0.000589622641509434	1696	10287	2149	F2R
R-HSA-1474228	Degradation of the extracellular matrix	0.982836369886853	-0.0173126326229539	111	11	0.00648584905660377	1696	10287	824,1514,6868,1520,7077,102,831,23473,8754,5663,823	CAPN2,CTSL,ADAM17,CTSS,TIMP2,ADAM10,CAST,CAPN7,ADAM9,PSEN1,CAPN1
R-HSA-192105	Synthesis of bile acids and bile salts	0.983265509836766	-0.0168760937424883	34	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-983712	Ion channel transport	0.983932091263841	-0.0161983972546372	209	24	0.0141509433962264	1696	10287	1182,57130,1831,5894,27032,535,526,51076,805,533,51382,476,488,6233,1185,6717,23545,527,528,9114,8992,53373,818,9550	CLCN3,ATP13A1,TSC22D3,RAF1,ATP2C1,ATP6V0A1,ATP6V1B2,CUTC,CALM2,ATP6V0B,ATP6V1D,ATP1A1,ATP2A2,RPS27A,CLCN6,SRI,ATP6V0A2,ATP6V0C,ATP6V1C1,ATP6V0D1,ATP6V0E1,TPCN1,CAMK2G,ATP6V1G1
R-HSA-5654695	PI-3K cascade:FGFR2	0.984214711738619	-0.0159112027462917	23	1	0.000589622641509434	1696	10287	5781	PTPN11
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.984214711738619	-0.0159112027462917	23	1	0.000589622641509434	1696	10287	8541	PPFIA3
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.986823036844449	-0.0132645496009969	24	1	0.000589622641509434	1696	10287	148022	TICAM1
R-HSA-5260271	Diseases of Immune System	0.986823036844449	-0.0132645496009969	24	1	0.000589622641509434	1696	10287	148022	TICAM1
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.986823036844449	-0.0132645496009969	24	1	0.000589622641509434	1696	10287	8541	PPFIA3
R-HSA-156588	Glucuronidation	0.986823036844449	-0.0132645496009969	24	1	0.000589622641509434	1696	10287	7360	UGP2
R-HSA-174824	Lipoprotein metabolism	0.988550843666684	-0.0115152025230563	74	6	0.0035377358490566	1696	10287	163,949,5566,1175,29801,19	AP2B1,SCARB1,PRKACA,AP2S1,ZDHHC8,ABCA1
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.988662780655077	-0.0114019755180072	91	8	0.00471698113207547	1696	10287	3015,3014,8313,6597,4221,3020,94239,79577	H2AFZ,H2AFX,AXIN2,SMARCA4,MEN1,H3F3A,H2AFV,CDC73
R-HSA-977068	Termination of O-glycan biosynthesis	0.989000580406849	-0.0110603604972622	25	1	0.000589622641509434	1696	10287	6483	ST3GAL2
R-HSA-3000157	Laminin interactions	0.989000580406849	-0.0110603604972622	25	1	0.000589622641509434	1696	10287	3688	ITGB1
R-HSA-5576892	Phase 0 - rapid depolarisation	0.989116684550675	-0.0109429719621986	47	3	0.0017688679245283	1696	10287	805,782,818	CALM2,CACNB1,CAMK2G
R-HSA-3000178	ECM proteoglycans	0.989764199961652	-0.0102885460802216	57	4	0.00235849056603774	1696	10287	7040,375790,3693,3688	TGFB1,AGRN,ITGB5,ITGB1
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	0.98982676821744	-0.0102253327631127	92	8	0.00471698113207547	1696	10287	93183,23556,53942,51604,8813,9091,54872,4061	PIGM,PIGN,CNTN5,PIGT,DPM1,PIGQ,PIGG,LY6E
R-HSA-1500931	Cell-Cell communication	0.990532321335683	-0.00951278204257174	133	13	0.00766509433962264	1696	10287	667,4301,7408,4690,5296,5879,3688,5781,23705,5339,1432,56288,6709	DST,AFDN,VASP,NCK1,PIK3R2,RAC1,ITGB1,PTPN11,CADM1,PLEC,MAPK14,PARD3,SPTAN1
R-HSA-977225	Amyloid fiber formation	0.990587267861866	-0.00945731186651896	101	9	0.00530660377358491	1696	10287	3015,6477,26088,6233,3014,6478,3020,23062,351	H2AFZ,SIAH1,GGA1,RPS27A,H2AFX,SIAH2,H3F3A,GGA2,APP
R-HSA-2187338	Visual phototransduction	0.990587267861866	-0.00945731186651896	101	9	0.00530660377358491	1696	10287	805,2339,375790,7804,9397,157506,79823,6383,51109	CALM2,FNTA,AGRN,LRP8,NMT2,RDH10,CAMKMT,SDC2,RDH11
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	0.990821640875239	-0.00922073978547902	67	5	0.00294811320754717	1696	10287	3015,3020,94239,10499,3014	H2AFZ,H3F3A,H2AFV,NCOA2,H2AFX
R-HSA-6794361	Interactions of neurexins and neuroligins at synapses	0.991039110299063	-0.00900127994243169	58	4	0.00235849056603774	1696	10287	9456,10611,2035,22839	HOMER1,PDLIM5,EPB41,DLGAP4
R-HSA-216083	Integrin cell surface interactions	0.99190706988652	-0.00812585563534661	68	5	0.00294811320754717	1696	10287	3696,375790,3384,3693,3688	ITGB8,AGRN,ICAM2,ITGB5,ITGB1
R-HSA-977606	Regulation of Complement cascade	0.992336035085238	-0.00769348401281104	27	1	0.000589622641509434	1696	10287	966	CD59
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.993147780971813	-0.00687580327903874	60	4	0.00235849056603774	1696	10287	667,1514,1520,5339	DST,CTSL,CTSS,PLEC
R-HSA-449147	Signaling by Interleukins	0.993582524150525	-0.00643815637293344	525	67	0.0395047169811321	1696	10287	4763,5894,8454,6597,598,5566,4067,1399,805,7409,5906,5707,5687,6464,3572,5296,200081,4893,143471,9978,8452,5695,4170,7335,3594,54472,5698,5515,5525,54014,3716,6233,23118,5714,6778,5709,6772,3688,5536,409,5594,5700,8649,8315,5715,2309,5708,2261,3662,5781,596,6774,818,6709,9655,7040,5682,3845,5605,5691,5595,5704,1445,332,84078,7534,3265	NF1,RAF1,CUL1,SMARCA4,BCL2L1,PRKACA,LYN,CRKL,CALM2,VAV1,RAP1A,PSMD1,PSMA6,SHC1,IL6ST,PIK3R2,TXLNA,NRAS,PSMA8,RBX1,CUL3,PSMB7,MCL1,UBE2V1,IL12RB1,TOLLIP,PSMB9,PPP2CA,PPP2R5A,BRWD1,JAK1,RPS27A,TAB2,PSMD8,STAT6,PSMD3,STAT1,ITGB1,PPP5C,ARRB2,MAPK1,PSMC1,LAMTOR3,BRAP,PSMD9,FOXO3,PSMD2,FGFR3,IRF4,PTPN11,BCL2,STAT3,CAMK2G,SPTAN1,SOCS5,TGFB1,PSMA1,KRAS,MAP2K2,PSMB3,MAPK3,PSMC4,CSK,BIRC5,KBTBD7,YWHAZ,HRAS
R-HSA-5621480	Dectin-2 family	0.993602904918893	-0.00641764417707023	28	1	0.000589622641509434	1696	10287	4067	LYN
R-HSA-446728	Cell junction organization	0.993868506431769	-0.00615036836828142	88	7	0.00412735849056604	1696	10287	667,4301,7408,5339,23705,56288,3688	DST,AFDN,VASP,PLEC,CADM1,PARD3,ITGB1
R-HSA-383280	Nuclear Receptor transcription pathway	0.993879807005524	-0.006138998142304	51	3	0.0017688679245283	1696	10287	6096,29959,6257	RORB,NRBP1,RXRB
R-HSA-420029	Tight junction interactions	0.995543270770612	-0.00446669005324748	30	1	0.000589622641509434	1696	10287	56288	PARD3
R-HSA-2980736	Peptide hormone metabolism	0.995689433826957	-0.00431988344820364	91	7	0.00412735849056604	1696	10287	23478,3799,11336,60559,4644,30001,60412	SEC11A,KIF5B,EXOC3,SPCS3,MYO5A,ERO1A,EXOC4
R-HSA-194068	Bile acid and bile salt metabolism	0.995953915569345	-0.00405429197669525	43	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.996538679317854	-0.00346732491162484	65	4	0.00235849056603774	1696	10287	7409,2261,5296,5781	VAV1,FGFR3,PIK3R2,PTPN11
R-HSA-1296072	Voltage gated Potassium channels	0.996553146679009	-0.00345280740574066	44	2	0.00117924528301887	1696	10287	3784,8514	KCNQ1,KCNAB2
R-HSA-1592389	Activation of Matrix Metalloproteinases	0.996895325027173	-0.00310950447478324	32	1	0.000589622641509434	1696	10287	7077	TIMP2
R-HSA-166658	Complement cascade	0.997064907121696	-0.00293940871038733	45	2	0.00117924528301887	1696	10287	966,1191	CD59,CLU
R-HSA-2672351	Stimuli-sensing channels	0.997373760964341	-0.00262969365115192	104	8	0.00471698113207547	1696	10287	805,1182,6233,1831,53373,5894,1185,6717	CALM2,CLCN3,RPS27A,TSC22D3,TPCN1,RAF1,CLCN6,SRI
R-HSA-427359	SIRT1 negatively regulates rRNA Expression	0.998018237761863	-0.00198372852716212	69	4	0.00235849056603774	1696	10287	3015,3020,94239,3014	H2AFZ,H3F3A,H2AFV,H2AFX
R-HSA-5576891	Cardiac conduction	0.998281498799781	-0.00171997951730913	142	12	0.00707547169811321	1696	10287	805,80228,782,476,488,28996,6717,84876,3784,10768,5566,818	CALM2,ORAI2,CACNB1,ATP1A1,ATP2A2,HIPK2,SRI,ORAI1,KCNQ1,AHCYL1,PRKACA,CAMK2G
R-HSA-6783783	Interleukin-10 signaling	0.998463026055991	-0.0015381563001173	49	2	0.00117924528301887	1696	10287	3716,6774	JAK1,STAT3
R-HSA-421270	Cell-cell junction organization	0.998609373293267	-0.00139159452540557	61	3	0.0017688679245283	1696	10287	4301,23705,56288	AFDN,CADM1,PARD3
R-HSA-112315	Transmission across Chemical Synapses	0.998654343074539	-0.0013465631347968	217	21	0.0123820754716981	1696	10287	5170,80331,6195,5894,2788,8541,5566,2783,805,782,4193,4905,115,163,1385,2771,5594,3265,1175,818,113	PDPK1,DNAJC5,RPS6KA1,RAF1,GNG7,PPFIA3,PRKACA,GNB2,CALM2,CACNB1,MDM2,NSF,ADCY9,AP2B1,CREB1,GNAI2,MAPK1,HRAS,AP2S1,CAMK2G,ADCY7
R-HSA-112310	Neurotransmitter Release Cycle	0.998890255213477	-0.00111036100921055	51	2	0.00117924528301887	1696	10287	8541,80331	PPFIA3,DNAJC5
R-HSA-1474290	Collagen formation	0.998921378235653	-0.00107920389543911	93	6	0.0035377358490566	1696	10287	667,1514,5479,1520,5339,8985	DST,CTSL,PPIB,CTSS,PLEC,PLOD3
R-HSA-1266738	Developmental Biology	0.99898529005102	-0.00101522511564583	1075	143	0.0843160377358491	1696	10287	892,3015,10154,375790,102,4763,1457,5361,1432,5621,805,1020,27,5906,5707,998,1808,5296,1785,163,10498,4893,4690,9978,51107,208,7430,58508,1809,4087,6233,5714,3984,3688,60,6093,409,5700,103910,823,8650,5440,389,7410,7204,6383,8649,23389,10664,4205,9967,5715,83464,7408,112950,84246,10092,63925,5438,5682,3845,10552,5605,5691,388,5704,5439,1445,51586,6478,9063,5306,57472,7528,5928,391,6938,5894,23512,6195,5879,288,10096,4627,4067,5566,5687,6464,6477,1212,1072,5441,5436,143471,10589,5433,8452,5695,4209,94239,5698,5515,3716,5525,5709,3014,8648,5536,3020,5594,4089,1175,8745,9612,8502,6929,8315,11091,79447,2309,23396,5708,2261,5781,8128,1385,6774,10499,818,11313,6837,6709,7040,387,23365,5430,5595,9125,782,84078,3516,7026,3265	CCNC,H2AFZ,PLXNC1,AGRN,ADAM10,NF1,CSNK2A1,PLXNA1,MAPK14,PRNP,CALM2,CDK5,ABL2,RAP1A,PSMD1,CDC42,DPYSL2,PIK3R2,DNM2,AP2B1,CARM1,NRAS,NCK1,RBX1,APH1A,AKT2,EZR,KMT2C,DPYSL3,SMAD2,RPS27A,PSMD8,LIMK1,ITGB1,ACTB,ROCK1,ARRB2,PSMC1,MYL12B,CAPN1,NUMB,POLR2K,RHOC,VAV2,TRIO,SDC2,LAMTOR3,MED13L,CTCF,MEF2A,THRAP3,PSMD9,APH1B,VASP,MED8,MED10,ARPC5,ZNF335,POLR2I,PSMA1,KRAS,ARPC1A,MAP2K2,PSMB3,RHOB,PSMC4,POLR2J,CSK,MED15,SIAH2,PIAS2,PITPNA,CNOT6,YY1,RBBP4,RHOG,TCF12,RAF1,SUZ12,RPS6KA1,RAC1,ANK3,ACTR3,MYH9,LYN,PRKACA,PSMA6,SHC1,SIAH1,CLTB,CFL1,POLR2L,POLR2G,PSMA8,DRAP1,POLR2D,CUL3,PSMB7,MEF2D,H2AFV,PSMB9,PPP2CA,JAK1,PPP2R5A,PSMD3,H2AFX,NCOA1,PPP5C,H3F3A,MAPK1,SMAD4,AP2S1,ADAM23,NCOR2,PKP4,TCF3,BRAP,WDR5,PAGR1,FOXO3,PIP5K1C,PSMD2,FGFR3,PTPN11,ST8SIA2,CREB1,STAT3,NCOA2,CAMK2G,LYPLA2,MED22,SPTAN1,TGFB1,RHOA,ARHGEF12,POLR2A,MAPK3,CNOT9,CACNB1,KBTBD7,RBPJ,NR2F2,HRAS
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.999124509668783	-0.000875873796706562	39	1	0.000589622641509434	1696	10287	2149	F2R
R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.999318550850907	-0.000681681441100283	106	7	0.00412735849056604	1696	10287	6566,1317,254428,133418,23446,6513,9194	SLC16A1,SLC31A1,SLC41A1,EMB,SLC44A1,SLC2A1,SLC16A7
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.999349834397641	-0.000650377051670105	443	50	0.0294811320754717	1696	10287	29933,4763,6195,5894,7204,8649,8315,5997,5715,2783,351,805,2261,5708,5906,5707,5687,6464,156,5296,1385,2149,818,6709,4893,143471,9978,2788,8452,5695,5682,3845,5698,5605,5691,5595,5704,5515,5525,3716,1445,6233,5714,5709,84078,5536,409,5594,5700,3265	GPR132,NF1,RPS6KA1,RAF1,TRIO,LAMTOR3,BRAP,RGS2,PSMD9,GNB2,APP,CALM2,FGFR3,PSMD2,RAP1A,PSMD1,PSMA6,SHC1,GRK2,PIK3R2,CREB1,F2R,CAMK2G,SPTAN1,NRAS,PSMA8,RBX1,GNG7,CUL3,PSMB7,PSMA1,KRAS,PSMB9,MAP2K2,PSMB3,MAPK3,PSMC4,PPP2CA,PPP2R5A,JAK1,CSK,RPS27A,PSMD8,PSMD3,KBTBD7,PPP5C,ARRB2,MAPK1,PSMC1,HRAS
R-HSA-375280	Amine ligand-binding receptors	0.999575463335699	-0.000424626805504052	43	1	0.000589622641509434	1696	10287	154	ADRB2
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.999645749771924	-0.000354312989511146	44	1	0.000589622641509434	1696	10287	4967	OGDH
R-HSA-73923	Lipid digestion, mobilization, and transport	0.999787083343543	-0.000212939326426078	115	7	0.00412735849056604	1696	10287	163,949,5566,1175,29801,19,51099	AP2B1,SCARB1,PRKACA,AP2S1,ZDHHC8,ABCA1,ABHD5
R-HSA-418555	G alpha (s) signalling events	0.999851200724554	-0.000148810347156603	146	10	0.00589622641509434	1696	10287	2778,156,2788,115,154,2771,409,5140,2783,113	GNAS,GRK2,GNG7,ADCY9,ADRB2,GNAI2,ARRB2,PDE3B,GNB2,ADCY7
R-HSA-397014	Muscle contraction	0.999916388312352	-8.36151833000063e-05	204	16	0.00943396226415094	1696	10287	80228,309,3784,5566,3693,140465,805,782,476,488,28996,6717,84876,10768,103910,818	ORAI2,ANXA6,KCNQ1,PRKACA,ITGB5,MYL6B,CALM2,CACNB1,ATP1A1,ATP2A2,HIPK2,SRI,ORAI1,AHCYL1,MYL12B,CAMK2G
R-HSA-373080	Class B/2 (Secretin family receptors)	0.999931021081638	-6.89812975167018e-05	92	4	0.00235849056603774	1696	10287	2778,2783,2788,8323	GNAS,GNB2,GNG7,FZD6
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.999933546143279	-6.64560648767349e-05	68	2	0.00117924528301887	1696	10287	8648,10499	NCOA1,NCOA2
R-HSA-5173105	O-linked glycosylation	0.999936789642369	-6.32123554895211e-05	114	6	0.0035377358490566	1696	10287	6483,56913,55568,51809,2590,9334	ST3GAL2,C1GALT1,GALNT10,GALNT7,GALNT2,B4GALT5
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.99995249827725	-4.75028509930863e-05	70	2	0.00117924528301887	1696	10287	5479,8985	PPIB,PLOD3
R-HSA-6809371	Formation of the cornified envelope	0.999959851025657	-4.01497803341896e-05	71	2	0.00117924528301887	1696	10287	8502,823	PKP4,CAPN1
R-HSA-3781865	Diseases of glycosylation	0.99996668390494	-3.33166500530377e-05	85	3	0.0017688679245283	1696	10287	4853,375790,6383	NOTCH2,AGRN,SDC2
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.999976599592815	-2.34006809790675e-05	59	1	0.000589622641509434	1696	10287	4853	NOTCH2
R-HSA-1296071	Potassium Channels	0.999979530915807	-2.04692936871984e-05	100	4	0.00235849056603774	1696	10287	3784,2783,2788,8514	KCNQ1,GNB2,GNG7,KCNAB2
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.99998460999839	-1.53901200370259e-05	124	6	0.0035377358490566	1696	10287	3106,3384,975,3133,3105,3688	HLA-B,ICAM2,CD81,HLA-E,HLA-A,ITGB1
R-HSA-1474244	Extracellular matrix organization	0.999993639801798	-6.36021842820563e-06	296	24	0.0141509433962264	1696	10287	7040,5479,6868,7077,375790,102,831,6383,5339,3384,5663,3693,1514,824,667,1520,3696,8425,4236,23473,3688,8754,8985,823	TGFB1,PPIB,ADAM17,TIMP2,AGRN,ADAM10,CAST,SDC2,PLEC,ICAM2,PSEN1,ITGB5,CTSL,CAPN2,DST,CTSS,ITGB8,LTBP4,MFAP1,CAPN7,ITGB1,ADAM9,PLOD3,CAPN1
R-HSA-211945	Phase 1 - Functionalization of compounds	0.999994896526192	-5.10348683070299e-06	109	4	0.00235849056603774	1696	10287	10728,8648,4835,10499	PTGES3,NCOA1,NQO2,NCOA2
R-HSA-112316	Neuronal System	0.999995444487749	-4.55552262772299e-06	349	30	0.017688679245283	1696	10287	5170,80331,6195,5894,2788,22839,10211,8541,3784,5566,2783,2035,805,5792,9456,782,4193,4905,115,163,1385,2771,10611,5594,10313,1175,3265,818,8514,113	PDPK1,DNAJC5,RPS6KA1,RAF1,GNG7,DLGAP4,FLOT1,PPFIA3,KCNQ1,PRKACA,GNB2,EPB41,CALM2,PTPRF,HOMER1,CACNB1,MDM2,NSF,ADCY9,AP2B1,CREB1,GNAI2,PDLIM5,MAPK1,RTN3,AP2S1,HRAS,CAMK2G,KCNAB2,ADCY7
R-HSA-211859	Biological oxidations	0.99999616958864	-3.83041869587989e-06	222	15	0.00884433962264151	1696	10287	27430,373156,2730,7360,4835,84836,191,1836,10728,494143,347734,8648,4548,10499,4144	MAT2B,GSTK1,GCLM,UGP2,NQO2,ABHD14B,AHCY,SLC26A2,PTGES3,CHAC2,SLC35B2,NCOA1,MTR,NCOA2,MAT2A
R-HSA-416476	G alpha (q) signalling events	0.999999910334219	-8.96657852924332e-08	192	9	0.00530660377358491	1696	10287	29933,156,2788,5296,7204,5997,2149,351,2783	GPR132,GRK2,GNG7,PIK3R2,TRIO,RGS2,F2R,APP,GNB2
R-HSA-6803157	Antimicrobial peptides	0.999999976512689	-2.34873108688656e-08	97	1	0.000589622641509434	1696	10287	1191	CLU
R-HSA-162582	Signal Transduction	0.999999998516736	-1.48326370887276e-09	2548	326	0.192216981132075	1696	10287	3015,7249,102,331,8454,79003,29904,805,1020,5707,5867,1785,163,55233,81929,64223,9736,4893,26574,208,23526,2788,3185,9212,8569,7454,4087,6233,5714,3984,8312,3688,527,7029,4086,409,3066,22919,5440,389,5562,7410,7204,2683,84133,4853,11243,5715,83464,79577,8837,6242,2280,10092,51564,23545,2771,79902,10959,23191,7867,157506,79837,4242,6016,154,26999,2002,5605,5691,388,355,51109,2339,5439,1445,1845,116985,5534,54820,1017,391,9322,6195,5894,9500,10096,5879,4627,83540,5566,8027,2783,3895,351,1399,25909,6464,488,5899,9110,51377,115,57122,9306,1027,9550,113,25989,5441,57120,10589,57551,1871,8452,5433,535,5698,94239,79682,3796,5515,5525,79980,3716,79823,6772,3014,6400,5536,7804,9612,8315,84335,54908,2309,7905,23509,23396,2962,8812,5708,5728,11108,9138,5781,9055,8313,1385,9040,10499,4670,10726,6709,5170,5530,7128,2648,10276,55288,5140,56928,5430,8772,2768,9146,81930,81029,7027,5597,5660,7533,51699,892,142678,261734,29933,375790,4763,1457,11004,9294,1432,329,5906,998,3572,5296,11140,5796,5347,26469,51107,9978,4690,4041,397,6659,27005,6009,80319,1874,51719,60,6794,1855,6093,5700,8992,103910,8650,7323,4659,1063,8649,6383,7072,3831,29924,4205,29127,5532,10787,5870,3337,5997,64759,9735,9794,9114,5438,51072,5682,3845,84447,989,10552,55843,9397,5704,6257,132884,2778,7248,389541,7534,4649,10163,5564,1540,6597,64121,526,4067,7409,533,5164,4193,5687,9928,1212,10768,2149,10006,11171,1856,10126,55114,330,5436,143471,5695,23401,57486,7456,55914,8050,23118,5933,5709,7289,6778,3020,80346,57154,5594,1175,4089,56288,27161,55143,4650,1452,5305,5996,8323,84888,5771,3799,2261,156,9181,79019,6774,818,7040,1455,6868,387,5575,23365,5905,4221,89941,5595,51382,332,9844,84078,23220,1869,3516,80152,528,57636,3265	H2AFZ,TSC2,ADAM10,XIAP,CUL1,MIS12,EEF2K,CALM2,CDK5,PSMD1,RAB4A,DNM2,AP2B1,MOB1A,SEH1L,MLST8,USP34,NRAS,AATF,AKT2,ARHGAP45,GNG7,HNRNPF,AURKB,MKNK1,WAS,SMAD2,RPS27A,PSMD8,LIMK1,AXIN1,ITGB1,ATP6V0C,TFDP2,SMAD1,ARRB2,HDAC2,MAPRE1,POLR2K,RHOC,PRKAA1,VAV2,TRIO,B4GALT1,ZNRF3,NOTCH2,PMF1,PSMD9,APH1B,CDC73,CFLAR,RTKN,FKBP1A,ARPC5,HDAC7,ATP6V0A2,GNAI2,NUP85,TMED2,CYFIP1,MAPKAPK3,RDH10,PIP4K2C,MFNG,RIT1,ADRB2,CYFIP2,ELK1,MAP2K2,PSMB3,RHOB,FAS,RDH11,FNTA,POLR2J,CSK,DUSP3,ARAP1,PPP3R1,NDE1,CDK2,RHOG,TRIP10,RPS6KA1,RAF1,MAGED1,ACTR3,RAC1,MYH9,NUF2,PRKACA,STAM,GNB2,KTN1,APP,CRKL,AHCTF1,SHC1,ATP2A2,RALB,MTMR4,UCHL5,ADCY9,NUP107,SOCS6,CDKN1B,ATP6V1G1,ADCY7,ULK3,POLR2L,GOPC,DRAP1,TAOK1,E2F3,CUL3,POLR2D,ATP6V0A1,PSMB9,H2AFV,CENPU,KIF2A,PPP2CA,PPP2R5A,DSN1,JAK1,CAMKMT,STAT1,H2AFX,SEL1L,PPP5C,LRP8,NCOR2,BRAP,AKT1S1,SPDL1,FOXO3,REEP5,POFUT1,PIP5K1C,GTF2F1,CCNK,PSMD2,PTEN,PRDM4,ARHGEF1,PTPN11,PRC1,AXIN2,CREB1,UBE2M,NCOA2,HNRNPM,NUDC,SPTAN1,PDPK1,PPP3CA,TNFAIP3,KAT2A,NET1,RHOT1,PDE3B,SPPL2B,POLR2A,FADD,GNA12,HGS,KIF18A,WNT5B,TFDP1,MAPK6,PSAP,YWHAH,VPS29,CCNC,MIB2,NPHP4,GPR132,AGRN,NF1,CSNK2A1,KIF2C,S1PR2,MAPK14,BIRC2,RAP1A,CDC42,IL6ST,PIK3R2,CDC37,PTPRK,PLK1,PTPN18,APH1A,RBX1,NCK1,LRP5,ARHGDIB,SOX4,USP21,RHEB,CXXC4,E2F4,CAB39,ACTB,STK11,DVL1,ROCK1,PSMC1,ATP6V0E1,MYL12B,NUMB,UBE2D3,PPP1R12A,CENPF,LAMTOR3,SDC2,TIA1,KLC1,EPN1,MEF2A,RACGAP1,PPP3CB,NCKAP1,RAB6A,DNAJB1,RGS2,TNS3,KNTC1,MAML1,ATP6V0D1,POLR2I,MEMO1,PSMA1,KRAS,SYVN1,SEPT7,ARPC1A,ARHGAP15,NMT2,PSMC4,RXRB,EVC2,GNAS,TSC1,LAMTOR4,YWHAZ,MYO9A,WASF2,PRKAB1,CYLD,SMARCA4,RRAGC,ATP6V1B2,LYN,VAV1,ATP6V0B,PDK2,MDM2,PSMA6,KIF14,CLTB,AHCYL1,F2R,ABI1,STRAP,DVL2,DNAL4,ARHGAP17,BIRC3,POLR2G,PSMA8,PSMB7,FRAT2,NLN,WIPF1,ERBIN,PDHX,TAB2,RBL1,PSMD3,TULP3,STAT6,H3F3A,REEP4,SMURF1,MAPK1,AP2S1,SMAD4,PARD3,AGO2,CDCA8,MYO9B,CSNK1A1,PIP4K2A,RGS1,FZD6,SPPL2A,PTPN2,KIF5B,FGFR3,GRK2,ARHGEF2,CENPM,STAT3,CAMK2G,TGFB1,CSNK1G2,ADAM17,RHOA,PRKAR1B,ARHGEF12,RANGAP1,MEN1,RHOT2,MAPK3,ATP6V1D,BIRC5,ELMO1,KBTBD7,DTX4,E2F1,RBPJ,CENPT,ATP6V1C1,ARHGAP23,HRAS
R-HSA-372790	Signaling by GPCR	0.999999999844242	-1.55757704658585e-10	1299	86	0.0507075471698113	1696	10287	391,29933,4763,6195,5894,5879,9294,5566,2783,351,805,1020,7409,5906,5707,5687,6464,998,5296,115,10768,2149,113,4893,143471,9978,208,2788,5695,8452,57486,5698,5515,5525,3716,6233,5714,5709,6093,5536,80346,409,5594,5700,389,7204,7410,8649,8315,5532,5997,5715,7905,5996,8323,5708,2261,156,9138,9181,1385,2771,818,6709,5170,5530,387,10276,5575,5682,23365,3845,154,5140,5605,5691,388,5595,5704,2778,2768,1445,84078,5534,5660,3265	RHOG,GPR132,NF1,RPS6KA1,RAF1,RAC1,S1PR2,PRKACA,GNB2,APP,CALM2,CDK5,VAV1,RAP1A,PSMD1,PSMA6,SHC1,CDC42,PIK3R2,ADCY9,AHCYL1,F2R,ADCY7,NRAS,PSMA8,RBX1,AKT2,GNG7,PSMB7,CUL3,NLN,PSMB9,PPP2CA,PPP2R5A,JAK1,RPS27A,PSMD8,PSMD3,ROCK1,PPP5C,REEP4,ARRB2,MAPK1,PSMC1,RHOC,TRIO,VAV2,LAMTOR3,BRAP,PPP3CB,RGS2,PSMD9,REEP5,RGS1,FZD6,PSMD2,FGFR3,GRK2,ARHGEF1,ARHGEF2,CREB1,GNAI2,CAMK2G,SPTAN1,PDPK1,PPP3CA,RHOA,NET1,PRKAR1B,PSMA1,ARHGEF12,KRAS,ADRB2,PDE3B,MAP2K2,PSMB3,RHOB,MAPK3,PSMC4,GNAS,GNA12,CSK,KBTBD7,PPP3R1,PSAP,HRAS
R-HSA-388396	GPCR downstream signaling	0.999999999876335	-1.23664744957979e-10	974	38	0.0224056603773585	1696	10287	391,29933,389,7410,5879,7204,9294,5997,7905,2783,351,5996,7409,6464,156,998,5296,115,9138,9181,2771,2149,113,5170,387,10276,208,2788,23365,154,5140,388,2778,2768,3716,6093,80346,409	RHOG,GPR132,RHOC,VAV2,RAC1,TRIO,S1PR2,RGS2,REEP5,GNB2,APP,RGS1,VAV1,SHC1,GRK2,CDC42,PIK3R2,ADCY9,ARHGEF1,ARHGEF2,GNAI2,F2R,ADCY7,PDPK1,RHOA,NET1,AKT2,GNG7,ARHGEF12,ADRB2,PDE3B,RHOB,GNAS,GNA12,JAK1,ROCK1,REEP4,ARRB2
R-HSA-418594	G alpha (i) signalling events	0.99999999992103	-7.89700078249003e-11	242	9	0.00530660377358491	1696	10287	2778,2788,115,9294,2771,351,2783,5996,113	GNAS,GNG7,ADCY9,S1PR2,GNAI2,APP,GNB2,RGS1,ADCY7
R-HSA-500792	GPCR ligand binding	0.999999999929963	-7.00368142718716e-11	453	11	0.00648584905660377	1696	10287	2778,29933,2788,57486,154,5660,9294,2149,351,2783,8323	GNAS,GPR132,GNG7,NLN,ADRB2,PSAP,S1PR2,F2R,APP,GNB2,FZD6
R-HSA-381753	Olfactory Signaling Pathway	0.999999999934145	-6.58553742028022e-11	391	2	0.00117924528301887	1696	10287	80346,7905	REEP4,REEP5
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.999999999952599	-4.74006271696671e-11	322	7	0.00412735849056604	1696	10287	57486,5660,29933,154,9294,2149,351	NLN,PSAP,GPR132,ADRB2,S1PR2,F2R,APP
R-HSA-375276	Peptide ligand-binding receptors	0.99999999997728	-2.27202548408002e-11	188	4	0.00235849056603774	1696	10287	57486,5660,2149,351	NLN,PSAP,F2R,APP
R-HSA-1482883	Acyl chain remodeling of DAG and TAG	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-70921	Histidine catabolism	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-977347	Serine biosynthesis	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-1483115	Hydrolysis of LPC	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-400451	Free fatty acids regulate insulin secretion	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-8850843	Phosphate bond hydrolysis by NTPDase proteins	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-444821	Relaxin receptors	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-448424	Interleukin-17 signaling	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-177128	Conjugation of salicylate with glycine	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-389397	Orexin and neuropeptides FF and QRFP bind to their respective receptors	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-194313	VEGF ligand-receptor interactions	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-5632681	Ligand-receptor interactions	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.999999999981829	-1.81707746943766e-11	8	0	0	1696	10287
R-HSA-6805567	Keratinization	0.999999999987979	-1.20211763851949e-11	214	2	0.00117924528301887	1696	10287	8502,823	PKP4,CAPN1
R-HSA-5602680	MyD88 deficiency (TLR5)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-265473	Trafficking of dietary sterols	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-8849472	PTK6 Down-Regulation	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-3359463	Defective CUBN causes hereditary megaloblastic anemia 1	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1368071	NR1D1 (REV-ERBA) represses gene expression	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-191650	Regulation of gap junction activity	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-379397	Enzymatic degradation of dopamine by COMT	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-163282	Mitochondrial transcription initiation	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5658034	HHAT G278V abrogates palmitoylation of Hh-Np	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-193681	Ceramide signalling	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-2395516	Electron transport from NADPH to Ferredoxin	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-190704	Oligomerization of connexins into connexons	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-3359462	Defective AMN causes hereditary megaloblastic anemia 1	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-350864	Regulation of thyroid hormone activity	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1299503	TWIK related potassium channel (TREK)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5339700	TCF7L2 mutants don't bind CTBP	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1296067	Potassium transport channels	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-392023	Adrenaline signalling through Alpha-2 adrenergic receptor	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-351200	Interconversion of polyamines	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-977442	GABA A (rho) receptor activation	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-380615	Serotonin clearance from the synaptic cleft	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-3296197	Hydroxycarboxylic acid-binding receptors	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-217271	FMO oxidises nucleophiles	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-139910	Activation of BMF and translocation to mitochondria	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1483248	Synthesis of PIPs at the ER membrane	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-427589	Type II Na+/Pi cotransporters	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-444411	Rhesus glycoproteins mediate ammonium transport.	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-190827	Transport of connexins along the secretory pathway	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-844615	The AIM2 inflammasome	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1234162	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-5250971	Toxicity of botulinum toxin type C (BoNT/C)	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-1307965	betaKlotho-mediated ligand binding	0.999999999991908	-8.09224996040081e-12	3	0	0	1696	10287
R-HSA-75205	Dissolution of Fibrin Clot	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-977441	GABA A receptor activation	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-375281	Hormone ligand-binding receptors	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-71240	Tryptophan catabolism	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-190375	FGFR2c ligand binding and activation	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-432047	Passive transport by Aquaporins	0.999999999994673	-5.32663981231552e-12	13	0	0	1696	10287
R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-428542	Regulation of Commissural axon pathfinding by Slit and Robo	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-173736	Alternative complement activation	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-176034	Interactions of Tat with host cellular proteins	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-1296061	HCN channels	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-379401	Dopamine clearance from the synaptic cleft	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-1296053	Classical Kir channels	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-8848584	Wax biosynthesis	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-194306	Neurophilin interactions with VEGF and VEGFR	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-2473224	Antagonism of Activin by Follistatin	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-5603037	IRAK4 deficiency (TLR5)	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-888593	Reuptake of GABA	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-427975	Proton/oligopeptide cotransporters	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-3000497	Scavenging by Class H Receptors	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-399710	Activation of AMPA receptors	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-209905	Catecholamine biosynthesis	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-417973	Adenosine P1 receptors	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-112126	ALKBH3 mediated reversal of alkylation damage	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-140179	Amine Oxidase reactions	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-428776	Class II GLUTs	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-173107	Binding and entry of HIV virion	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-8935690	Miscellaneous digestion events	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-1296025	ATP sensitive Potassium channels	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-390650	Histamine receptors	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-167060	NGF processing	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-112313	Neurotransmitter uptake and Metabolism In Glial Cells	0.999999999995455	-4.54466585891877e-12	4	0	0	1696	10287
R-HSA-181431	Acetylcholine Binding And Downstream Events	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-209952	Peptide hormone biosynthesis	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-190322	FGFR4 ligand binding and activation	0.999999999995888	-4.11221684357627e-12	14	0	0	1696	10287
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-418038	Nucleotide-like (purinergic) receptors	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-549132	Organic cation/anion/zwitterion transport	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-190242	FGFR1 ligand binding and activation	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-1963642	PI3K events in ERBB2 signaling	0.999999999996676	-3.32400773923872e-12	16	0	0	1696	10287
R-HSA-5336415	Uptake and function of diphtheria toxin	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-388479	Vasopressin-like receptors	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-190370	FGFR1b ligand binding and activation	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-193144	Estrogen biosynthesis	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-8851907	MET activates PI3K/AKT signaling	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-5660668	CLEC7A/inflammasome pathway	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-2142700	Synthesis of Lipoxins (LX)	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-193993	Mineralocorticoid biosynthesis	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-947581	Molybdenum cofactor biosynthesis	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-5626978	TNFR1-mediated ceramide production	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-173623	Classical antibody-mediated complement activation	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-205025	NADE modulates death signalling	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-8857538	PTK6 promotes HIF1A stabilization	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-187015	Activation of TRKA receptors	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-2187335	The retinoid cycle in cones (daylight vision)	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-211916	Vitamins	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-177135	Conjugation of benzoate with glycine	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-428808	Na+-dependent glucose transporters	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-6806942	MET Receptor Activation	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-166662	Lectin pathway of complement activation	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-6799990	Metal sequestration by antimicrobial proteins	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-189483	Heme degradation	1.00000000000143	1.42667526555583e-12	6	0	0	1696	10287
R-HSA-70350	Fructose catabolism	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-390648	Muscarinic acetylcholine receptors	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-5683678	Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8849468	PTK6 Regulates Proteins Involved in RNA Processing	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-446205	Synthesis of GDP-mannose	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-74713	IRS activation	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-167827	The proton buffering model	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-1300652	Sperm:Oocyte Membrane Binding	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-2161517	Abacavir transmembrane transport	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-444209	Free fatty acid receptors	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-1614517	Sulfide oxidation to sulfate	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8852405	Signaling by MST1	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-166187	Mitochondrial Uncoupling Proteins	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-114516	Disinhibition of SNARE formation	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-390651	Dopamine receptors	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-1306955	GRB7 events in ERBB2 signaling	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-187024	NGF-independant TRKA activation	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-2855086	Ficolins bind to repetitive carbohydrate structures on the target cell surface	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-380095	Tachykinin receptors bind tachykinins	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-389599	Alpha-oxidation of phytanate	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-6785470	tRNA processing in the mitochondrion	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-112303	Electric Transmission Across Gap Junctions	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-561048	Organic anion transport	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8866423	VLDL biosynthesis	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-391906	Leukotriene receptors	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8866376	Reelin signalling pathway	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8849473	PTK6 Expression	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-8866911	TFAP2 (AP-2) family regulates transcription of cell cycle factors	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-426048	Arachidonate production from DAG	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-112307	Transmission across Electrical Synapses	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-167826	The fatty acid cycling model	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-209931	Serotonin and melatonin biosynthesis	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-5661270	Catabolism of glucuronate to xylulose-5-phosphate	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-5662702	Melanin biosynthesis	1.00000000000269	2.68649074611649e-12	5	0	0	1696	10287
R-HSA-916853	Degradation of GABA	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-205017	NFG and proNGF binds to p75NTR	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-1483152	Hydrolysis of LPE	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-168268	Virus Assembly and Release	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-192905	vRNP Assembly	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-177162	Conjugation of phenylacetate with glutamine	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5579031	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-141334	PAOs oxidise polyamines to amines	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-75102	C6 deamination of adenosine	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-844623	The IPAF inflammasome	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5545619	XAV939 inhibits tankyrase, stabilizing AXIN	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-1614603	Cysteine formation from homocysteine	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-380612	Metabolism of serotonin	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-75064	mRNA Editing: A to I Conversion	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-164939	Nef mediated downregulation of CD28 cell surface expression	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-6804754	Regulation of TP53 Expression	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-156582	Acetylation	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-141424	Amplification of signal from the kinetochores	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-888568	GABA synthesis	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-75896	Plasmalogen biosynthesis	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-190872	Transport of connexons to the plasma membrane	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-168316	Assembly of Viral Components at the Budding Site	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-428559	Proton-coupled neutral amino acid transporters	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5688354	Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-203754	NOSIP mediated eNOS trafficking	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-198765	Signalling to ERK5	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-351143	Agmatine biosynthesis	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-70688	Proline catabolism	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-8942233	Intestinal infectious diseases	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-114294	Activation, translocation and oligomerization of BAX	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-211736	Stimulation of the cell death response by PAK-2p34	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-187042	TRKA activation by NGF	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5602636	IKBKB deficiency causes SCID	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-8854521	Interaction between PHLDA1 and AURKA	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-8849175	Threonine catabolism	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5619107	Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-451307	Activation of Na-permeable Kainate Receptors	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-77042	Formation of editosomes by ADAR proteins	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	1.00000000000334	3.33600508328757e-12	2	0	0	1696	10287
R-HSA-211935	Fatty acids	1.00000000000576	5.75928436153714e-12	15	0	0	1696	10287
R-HSA-391903	Eicosanoid ligand-binding receptors	1.00000000000576	5.75928436153714e-12	15	0	0	1696	10287
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	1.00000000000576	5.75928436153714e-12	15	0	0	1696	10287
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-6809583	Retinoid metabolism disease events	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1222499	Response of Mtb to phagocytosis	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5340573	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-3359454	Defective TCN2 causes hereditary megaloblastic anemia	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5602410	TLR3 deficiency - HSE	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-389542	NADPH regeneration	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-112122	ALKBH2 mediated reversal of alkylation damage	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1839128	FGFR4 mutant receptor activation	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2534343	Interaction With Cumulus Cells	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-3248023	Regulation by TREX1	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1222352	Latent infection of Homo sapiens with Mycobacterium tuberculosis	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-169131	Inhibition of PKR	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5657655	MGMT-mediated DNA damage reversal	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-162589	Reverse Transcription of HIV RNA	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1483076	Synthesis of CL	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-171286	Synthesis and processing of ENV and VPU	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-140180	COX reactions	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-8853333	Signaling by FGFR2 fusions	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-162585	Uncoating of the HIV Virion	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-164525	Plus-strand DNA synthesis	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5263617	Metabolism of ingested MeSeO2H into MeSeH	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1839120	Signaling by FGFR1 amplification mutants	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-164516	Minus-strand DNA synthesis	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5250982	Toxicity of tetanus toxin (TeNT)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2023837	Signaling by FGFR2 amplification mutants	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1222449	Mtb iron assimilation by chelation	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-1300645	Acrosome Reaction	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2408552	Methylation of MeSeH for excretion	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-3359457	Defective GIF causes intrinsic factor deficiency	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-975574	Reactions specific to the hybrid N-glycan synthesis pathway	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-2142696	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5602415	UNC93B1 deficiency - HSE	1.00000000000604	6.04119532177094e-12	1	0	0	1696	10287
R-HSA-5661231	Metallothioneins bind metals	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-2022923	Dermatan sulfate biosynthesis	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-71182	Phenylalanine and tyrosine catabolism	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-75072	mRNA Editing	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-71288	Creatine metabolism	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-2485179	Activation of the phototransduction cascade	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-5602498	MyD88 deficiency (TLR2/4)	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-549127	Organic cation transport	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-5660526	Response to metal ions	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-211999	CYP2E1 reactions	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-193048	Androgen biosynthesis	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-1839122	Signaling by activated point mutants of FGFR1	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	1.00000000000678	6.78296566288737e-12	11	0	0	1696	10287
R-HSA-168799	Neurotoxicity of clostridium toxins	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-1250342	PI3K events in ERBB4 signaling	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-209968	Thyroxine biosynthesis	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-70635	Urea cycle	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-399997	Acetylcholine regulates insulin secretion	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-419812	Calcitonin-like ligand receptors	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-190377	FGFR2b ligand binding and activation	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-159740	Gamma-carboxylation of protein precursors	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	1.00000000000701	7.00779043027024e-12	10	0	0	1696	10287
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	1.00000000000872	8.71618095633362e-12	19	0	0	1696	10287
R-HSA-5576886	Phase 4 - resting membrane potential	1.00000000000872	8.71618095633362e-12	19	0	0	1696	10287
R-HSA-190861	Gap junction assembly	1.00000000000872	8.71618095633362e-12	19	0	0	1696	10287
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters	1.00000000000872	8.71618095633362e-12	19	0	0	1696	10287
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	1.00000000000957	9.56546391470978e-12	22	0	0	1696	10287
R-HSA-166663	Initial triggering of complement	1.00000000000957	9.56546391470978e-12	22	0	0	1696	10287
R-HSA-194002	Glucocorticoid biosynthesis	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-156587	Amino Acid conjugation	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-391908	Prostanoid ligand receptors	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-2243919	Crosslinking of collagen fibrils	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-419771	Opsins	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-8854691	Interleukin-19, 20, 22, 24	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-1300642	Sperm Motility And Taxes	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-425986	Sodium/Proton exchangers	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-2474795	Diseases associated with visual transduction	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-189085	Digestion of dietary carbohydrate	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-2453864	Retinoid cycle disease events	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-75094	Formation of the Editosome	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-159424	Conjugation of carboxylic acids	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-2214320	Anchoring fibril formation	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-1296052	Ca2+ activated K+ channels	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-72200	mRNA Editing: C to U Conversion	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-1462054	Alpha-defensins	1.00000000001101	1.10056579670449e-11	9	0	0	1696	10287
R-HSA-1475029	Reversible hydration of carbon dioxide	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-190373	FGFR1c ligand binding and activation	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-390666	Serotonin receptors	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-73621	Pyrimidine catabolism	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-71384	Ethanol oxidation	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-211958	Miscellaneous substrates	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-1296346	Tandem pore domain potassium channels	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-209822	Glycoprotein hormones	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-417957	P2Y receptors	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-1433617	Regulation of signaling by NODAL	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-166786	Creation of C4 and C2 activators	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-211979	Eicosanoids	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-4641265	Repression of WNT target genes	1.0000000000117	1.16949881798027e-11	12	0	0	1696	10287
R-HSA-174577	Activation of C3 and C5	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-447043	Neurofascin interactions	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3656225	Defective CHST6 causes MCDC1	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-447038	NrCAM interactions	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-196791	Vitamin D (calciferol) metabolism	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3595177	Defective CHSY1 causes TPBS	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-429593	Inositol transporters	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-6814848	Glycerophospholipid catabolism	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-5619102	SLC transporter disorders	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-5603029	IkBA variant leads to EDA-ID	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3595172	Defective CHST3 causes SEDCJD	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-448706	Interleukin-1 processing	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	1.00000000001204	1.20351940452244e-11	7	0	0	1696	10287
R-HSA-5669034	TNFs bind their physiological receptors	1.0000000000141	1.41020546067406e-11	30	0	0	1696	10287
R-HSA-390522	Striated Muscle Contraction	1.00000000001776	1.7756822760661e-11	34	0	0	1696	10287
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	1.00000000001893	1.89294243392753e-11	18	0	0	1696	10287
R-HSA-209776	Amine-derived hormones	1.00000000001893	1.89294243392753e-11	18	0	0	1696	10287
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	1.00000000001893	1.89294243392753e-11	18	0	0	1696	10287
R-HSA-5423646	Aflatoxin activation and detoxification	1.00000000002184	2.18368449992775e-11	21	0	0	1696	10287
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	1.00000000002184	2.18368449992775e-11	21	0	0	1696	10287
R-HSA-211981	Xenobiotics	1.00000000002377	2.37689353388389e-11	25	0	0	1696	10287
R-HSA-3295583	TRP channels	1.00000000002377	2.37689353388389e-11	25	0	0	1696	10287
R-HSA-975298	Ligand-gated ion channel transport	1.00000000002403	2.40347337670202e-11	26	0	0	1696	10287
R-HSA-389977	Post-chaperonin tubulin folding pathway	1.00000000002489	2.48890533443339e-11	23	0	0	1696	10287
R-HSA-5083635	Defective B3GALTL causes Peters-plus syndrome (PpS)	1.00000000002575	2.57510632243337e-11	37	0	0	1696	10287
R-HSA-2033519	Activated point mutants of FGFR2	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-1482922	Acyl chain remodelling of PI	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-435354	Zinc transporters	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-192456	Digestion of dietary lipid	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	1.00000000002609	2.60857913850604e-11	17	0	0	1696	10287
R-HSA-174800	Chylomicron-mediated lipid transport	1.00000000002625	2.62522345848477e-11	28	0	0	1696	10287
R-HSA-8948216	Collagen chain trimerization	1.00000000002746	2.74569501410623e-11	47	0	0	1696	10287
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	1.000000000028	2.80046992986644e-11	39	0	0	1696	10287
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	1.000000000028	2.80046992986644e-11	39	0	0	1696	10287
R-HSA-190241	FGFR2 ligand binding and activation	1.00000000002881	2.880746677498e-11	20	0	0	1696	10287
R-HSA-380108	Chemokine receptors bind chemokines	1.00000000003085	3.08532882322907e-11	48	0	0	1696	10287
R-HSA-114508	Effects of PIP2 hydrolysis	1.00000000003175	3.17525149341064e-11	27	0	0	1696	10287
R-HSA-1461957	Beta defensins	1.00000000003391	3.39071326989957e-11	42	0	0	1696	10287
R-HSA-1461973	Defensins	1.00000000003659	3.65865755262216e-11	51	0	0	1696	10287